#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P06797 uniprotkb:Q5I2A0 intact:EBI-7876993|uniprotkb:Q91UZ0|intact:MINT-1863740|ensembl:ENSMUSP00000021933|ensembl:ENSMUSP00000152169 intact:EBI-7876970|intact:MINT-7714222|uniprotkb:Q6PG99 psi-mi:catl1_mouse(display_long)|uniprotkb:Ctsl(gene name)|psi-mi:Ctsl(display_short)|uniprotkb:Ctsl1(gene name synonym)|uniprotkb:Major excreted protein(gene name synonym)|uniprotkb:p39 cysteine proteinase(gene name synonym)|uniprotkb:Cathepsin L1(gene name synonym) psi-mi:spa3g_mouse(display_long)|uniprotkb:Serpina3g(gene name)|psi-mi:Serpina3g(display_short)|uniprotkb:Spi2A(gene name synonym)|uniprotkb:Serine protease inhibitor 2A(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Konjar et al. (2010) pubmed:20338168|imex:IM-15688|mint:MINT-7714217|mint:d-10-00110 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7877036|mint:MINT-7714241|imex:IM-15688-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034114.1|refseq:XP_006517143.1|go:"GO:0043373"(CD4-positive, alpha-beta T cell lineage commitment)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046697"(decidualization)|go:"GO:0048002"(antigen processing and presentation of peptide antigen)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060309"(elastin catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|go:"GO:0043204"(perikaryon)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|rcsb pdb:1MVV|reactome:R-MMU-1442490|reactome:R-MMU-1474228|reactome:R-MMU-1679131|reactome:R-MMU-2022090|reactome:R-MMU-2132295|reactome:R-MMU-8939242|ensembl:ENSMUSG00000021477(gene)|ensembl:ENSMUST00000021933(transcript)|ensembl:ENSMUST00000222517(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005773"(vacuole)|go:"GO:0005902"(microvillus)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006955"(immune response)|go:"GO:0007154"(cell communication)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016807"(cysteine-type carboxypeptidase activity)|go:"GO:0021675"(nerve development)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030984"(kininogen binding)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0034230"(enkephalin processing)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0042393"(histone binding)|go:"GO:0042583"(chromaffin granule)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0043005"(neuron projection)|mint:MINT-7714243(identity) interpro:IPR023795|refseq:NP_033277.1|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|go:"GO:0002250"(adaptive immune response)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR042178|interpro:IPR042185|interpro:IPR036186|mint:MINT-7714244(identity) go:"GO:0005730"(nucleolus) comment:mint|function:Important for the overall degradation of proteins in lysosomes comment:mint figure legend:f3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2010/03/18 2014/10/16 rogid:oFAYLk0ZhXto2nbmx/lUdQc2EJM10090 rogid:4nu1nhyoF5CjLg1MxwdUAh1MmRw10090 intact-crc:6EAECE3D6A5D889B|rigid:+EmqPkgHj5umm6xw6iQS8/TxP6U false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P35550 uniprotkb:Q5I2A0 intact:EBI-7817407|ensembl:ENSMUSP00000037613|intact:MINT-1854224|uniprotkb:Q99L58 intact:EBI-7876970|intact:MINT-7714222|uniprotkb:Q6PG99 psi-mi:fbrl_mouse(display_long)|uniprotkb:Fbl(gene name)|psi-mi:Fbl(display_short)|uniprotkb:Nucleolar protein 1(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)|uniprotkb:U6 snRNA 2'-O-methyltransferase fibrillarin(gene name synonym) psi-mi:spa3g_mouse(display_long)|uniprotkb:Serpina3g(gene name)|psi-mi:Serpina3g(display_short)|uniprotkb:Spi2A(gene name synonym)|uniprotkb:Serine protease inhibitor 2A(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Konjar et al. (2010) pubmed:20338168|imex:IM-15688|mint:MINT-7714217|mint:d-10-00110 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7877096|mint:MINT-7714245|imex:IM-15688-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0016074"("sno(s)RNA metabolic process")|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|mint:P35550|reactome:R-MMU-6791226|go:"GO:0001652"(granular component)|ensembl:ENSMUSG00000046865(gene)|ensembl:ENSMUST00000042405(transcript)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|refseq:NP_032017.2|mint:MINT-7714248(identity) interpro:IPR023795|refseq:NP_033277.1|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|go:"GO:0002250"(adaptive immune response)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR042178|interpro:IPR042185|interpro:IPR036186|mint:MINT-7714247(identity) go:"GO:0005730"(nucleolus) function:Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA|comment:mint|comment:homomint comment:mint figure legend:f2d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2010/03/18 2014/10/16 rogid:+sPcLBU2pW5qt05z4awAKpVQryY10090 rogid:4nu1nhyoF5CjLg1MxwdUAh1MmRw10090 intact-crc:F55AE6B34CDB3338|rigid:mKUesXNraEhXh/OV5q2Ymg4fOGQ false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)