#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61321	uniprotkb:O70546	intact:EBI-986524|uniprotkb:Q61322|uniprotkb:Q61323|ensembl:ENSMUSP00000036150|uniprotkb:B2RQH3	intact:EBI-1573712|uniprotkb:A2AID2|uniprotkb:Q6DI80|uniprotkb:Q7TSG4|ensembl:ENSMUSP00000045862	psi-mi:six4_mouse(display_long)|uniprotkb:Sine oculis homeobox homolog 4(gene name synonym)|uniprotkb:Skeletal muscle-specific ARE-binding protein AREC3(gene name synonym)|uniprotkb:Six4(gene name)|psi-mi:Six4(display_short)|uniprotkb:Arec3(gene name synonym)	psi-mi:kdm6a_mouse(display_long)|uniprotkb:Ubiquitously transcribed X chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:Ubiquitously transcribed TPR protein on the X chromosome(gene name synonym)|uniprotkb:Kdm6a(gene name)|psi-mi:Kdm6a(display_short)|uniprotkb:Utx(gene name synonym)|uniprotkb:Histone demethylase UTX(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6A"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Seenundun et al. (2010)	pubmed:20300060|imex:IM-15067|mint:MINT-7949308|doi:10.1038/emboj.2010.37	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7859007|mint:MINT-7949359|imex:IM-15067-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034460(gene)|ensembl:ENSMUST00000043208(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0008584"(male gonad development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030238"(male sex determination)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046661"(male sex differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0098528"(skeletal muscle fiber differentiation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|go:"GO:0061197"(fungiform papilla morphogenesis)|refseq:NP_035512.1|mint:MINT-7949362(identity)	refseq:NP_033509.1|refseq:NP_001297373.1|ensembl:ENSMUSG00000037369(gene)|ensembl:ENSMUST00000044484(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021915"(neural tube development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0072359"(circulatory system development)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-3214842|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|mint:MINT-7949361(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f4a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/07/01	2014/10/16	rogid:xA8jh19jU/Po4pKrRDx4aYpmM9Q10090	rogid:qMPUV3quo7aj9ipc9Abu2RWGX1M10090	intact-crc:2CEF94DD97DD2A42|rigid:j0RrLk5hymbCR7Y7CwzgpUY2Sig	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61321	uniprotkb:O70546	intact:EBI-986524|uniprotkb:Q61322|uniprotkb:Q61323|ensembl:ENSMUSP00000036150|uniprotkb:B2RQH3	intact:EBI-1573712|uniprotkb:A2AID2|uniprotkb:Q6DI80|uniprotkb:Q7TSG4|ensembl:ENSMUSP00000045862	psi-mi:six4_mouse(display_long)|uniprotkb:Sine oculis homeobox homolog 4(gene name synonym)|uniprotkb:Skeletal muscle-specific ARE-binding protein AREC3(gene name synonym)|uniprotkb:Six4(gene name)|psi-mi:Six4(display_short)|uniprotkb:Arec3(gene name synonym)	psi-mi:kdm6a_mouse(display_long)|uniprotkb:Ubiquitously transcribed X chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:Ubiquitously transcribed TPR protein on the X chromosome(gene name synonym)|uniprotkb:Kdm6a(gene name)|psi-mi:Kdm6a(display_short)|uniprotkb:Utx(gene name synonym)|uniprotkb:Histone demethylase UTX(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6A"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Seenundun et al. (2010)	pubmed:20300060|imex:IM-15067|mint:MINT-7949308|doi:10.1038/emboj.2010.37	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7859037|mint:MINT-7949373|imex:IM-15067-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034460(gene)|ensembl:ENSMUST00000043208(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0008584"(male gonad development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030238"(male sex determination)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046661"(male sex differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0098528"(skeletal muscle fiber differentiation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|go:"GO:0061197"(fungiform papilla morphogenesis)|refseq:NP_035512.1|mint:MINT-7949378(identity)	refseq:NP_033509.1|refseq:NP_001297373.1|ensembl:ENSMUSG00000037369(gene)|ensembl:ENSMUST00000044484(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021915"(neural tube development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0072359"(circulatory system development)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-3214842|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|mint:MINT-7949376(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f4a sf6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/07/01	2014/10/16	rogid:xA8jh19jU/Po4pKrRDx4aYpmM9Q10090	rogid:qMPUV3quo7aj9ipc9Abu2RWGX1M10090	intact-crc:2D2826DD92B56906|rigid:j0RrLk5hymbCR7Y7CwzgpUY2Sig	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UIU6	uniprotkb:O15550	intact:EBI-7859117|ensembl:ENSP00000216513|uniprotkb:Q4V764|intact:MINT-7949397|uniprotkb:Q4QQH5	intact:EBI-4292203|uniprotkb:Q52LL9|uniprotkb:Q5JVQ7|intact:EBI-28988602|ensembl:ENSP00000367203	psi-mi:six4_human(display_long)|uniprotkb:SIX4(gene name)|psi-mi:SIX4(display_short)|uniprotkb:Sine oculis homeobox homolog 4(gene name synonym)	psi-mi:kdm6a_human(display_long)|uniprotkb:KDM6A(gene name)|psi-mi:KDM6A(display_short)|uniprotkb:UTX(gene name synonym)|uniprotkb:Histone demethylase UTX(gene name synonym)|uniprotkb:Ubiquitously-transcribed TPR protein on the X chromosome(gene name synonym)|uniprotkb:Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6A"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Seenundun et al. (2010)	pubmed:20300060|imex:IM-15067|mint:MINT-7949308|doi:10.1038/emboj.2010.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7859110|mint:MINT-7949384|imex:IM-15067-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100625(gene)|ensembl:ENST00000216513(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0008584"(male gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030238"(male sex determination)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043586"(tongue development)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046661"(male sex differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061197"(fungiform papilla morphogenesis)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0098528"(skeletal muscle fiber differentiation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_059116.3|ensembl:ENSP00000216513|mint:MINT-7949389(identity)	refseq:NP_066963.2|ensembl:ENSG00000147050(gene)|ensembl:ENST00000377967(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O15550|rcsb pdb:3AVR|rcsb pdb:3AVS|rcsb pdb:6FUK|rcsb pdb:6FUL|reactome:R-HSA-3214842|reactome:R-HSA-5617472|ensembl:ENSP00000367203|dip:DIP-46192N|mint:MINT-7949387(identity)	go:"GO:0005634"(nucleus)	comment:mint	-	comment:homomint|comment:mint|figure legend:f4b sf6b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/07/01	2014/10/16	rogid:YmHeGHHL3o6cF42qjXIFZ7fOZl49606	rogid:sqg+Ikkgvz0uT/gMx1wYs9FaDbI9606	intact-crc:398BC6C91916B337|rigid:7ZZXYoEqqF41vAYrvML71+sp9+Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)