#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P61830	ddbj/embl/genbank:X66738	intact:EBI-8098|uniprotkb:E9PAG1|uniprotkb:P02303|uniprotkb:P13996|uniprotkb:Q6B1U3|uniprotkb:Q6Q7G9|uniprotkb:D6VQ11|ensemblfungi:YBR010W|ensemblfungi:YNL031C	intact:EBI-2650833	psi-mi:h3_yeast(display_long)|uniprotkb:SIN2(gene name synonym)|uniprotkb:YNL031C(locus name)|uniprotkb:N2749(orf name)|uniprotkb:HHT1(gene name)|psi-mi:HHT1(display_short)|uniprotkb:YBR010W(locus name)|uniprotkb:YBR0201(orf name)|uniprotkb:HHT2(gene name)|psi-mi:HHT2(display_short)	psi-mi:"cen1:ura4_spomb_dna"(display_short)|psi-mi:X66738(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650700|imex:IM-13771-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_009564.1|refseq:NP_014367.1|sgd:S000000214|sgd:S000004976|mint:P61830|dip:DIP-417N|ensemblfungi:YBR010W(gene)|ensemblfungi:YBR010W_mRNA(transcript)|ensemblfungi:YNL031C(gene)|ensemblfungi:YNL031C_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043505"(CENP-A containing nucleosome)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1ID3|rcsb pdb:1M1D|rcsb pdb:1PEG|rcsb pdb:1PU9|rcsb pdb:1PUA|rcsb pdb:1QSN|rcsb pdb:2CNX|rcsb pdb:2H2G|rcsb pdb:2IDC|rcsb pdb:2JMJ|rcsb pdb:2RNW|rcsb pdb:2RNX|rcsb pdb:2RSN|rcsb pdb:3MP1|rcsb pdb:3MP6|rcsb pdb:3Q33|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:5D7E|rcsb pdb:5IOK|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6J2P|rcsb pdb:6KMJ|rcsb pdb:7K7G	-	-	crc64:A6115FEB480AC67A	comment:ura4+ is a marker gene.	comment:"Anti-H3K9me2 chromatin immunoprecipitation (ChIP) on stc1-delta cells indicates that, as in dcr1-delta cells, H3K9me2 is only partially reduced on centromeric outer repeats (cen-dg) but is completely lost from the cen1:ura4+ marker gene. Consistent with this, a reduced level of Swi6 remains associated with outer repeats, but not with cen1:ura4+."|figure legend:Fig 1E.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:jtDVNjrs2tJMmr/dqrvnNiQ2ppQ559292	-	intact-crc:58B6E475DFC04526	false	N6,N6-dimethyl-L-lysine:9-9	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P61830	intact:EBI-2650713	intact:EBI-8098|uniprotkb:E9PAG1|uniprotkb:P02303|uniprotkb:P13996|uniprotkb:Q6B1U3|uniprotkb:Q6Q7G9|uniprotkb:D6VQ11|ensemblfungi:YBR010W|ensemblfungi:YNL031C	-	psi-mi:h3_yeast(display_long)|uniprotkb:SIN2(gene name synonym)|uniprotkb:YNL031C(locus name)|uniprotkb:N2749(orf name)|uniprotkb:HHT1(gene name)|psi-mi:HHT1(display_short)|uniprotkb:YBR010W(locus name)|uniprotkb:YBR0201(orf name)|uniprotkb:HHT2(gene name)|psi-mi:HHT2(display_short)	psi-mi:cen-dg_spombe_dna(display_short)|psi-mi:EBI-2650713(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650700|imex:IM-13771-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_009564.1|refseq:NP_014367.1|sgd:S000000214|sgd:S000004976|mint:P61830|dip:DIP-417N|ensemblfungi:YBR010W(gene)|ensemblfungi:YBR010W_mRNA(transcript)|ensemblfungi:YNL031C(gene)|ensemblfungi:YNL031C_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043505"(CENP-A containing nucleosome)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1ID3|rcsb pdb:1M1D|rcsb pdb:1PEG|rcsb pdb:1PU9|rcsb pdb:1PUA|rcsb pdb:1QSN|rcsb pdb:2CNX|rcsb pdb:2H2G|rcsb pdb:2IDC|rcsb pdb:2JMJ|rcsb pdb:2RNW|rcsb pdb:2RNX|rcsb pdb:2RSN|rcsb pdb:3MP1|rcsb pdb:3MP6|rcsb pdb:3Q33|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:5D7E|rcsb pdb:5IOK|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6J2P|rcsb pdb:6KMJ|rcsb pdb:7K7G	-	-	crc64:A6115FEB480AC67A	comment:"In S. pombe, a broad distribution of heterochromatin is observed at pericentromeric regions, subtelomeres and the silent mating-type locus. These loci share a common feature: each contains dg and/or dh repeats that serve as RNA interference (RNAi)-dependent heterochromatin nucleation centres."	comment:"Anti-H3K9me2 chromatin immunoprecipitation (ChIP) on stc1-delta cells indicates that, as in dcr1-delta cells, H3K9me2 is only partially reduced on centromeric outer repeats (cen-dg) but is completely lost from the cen1:ura4+ marker gene. Consistent with this, a reduced level of Swi6 remains associated with outer repeats, but not with cen1:ura4+."|figure legend:Fig 1E.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:jtDVNjrs2tJMmr/dqrvnNiQ2ppQ559292	-	intact-crc:58B6E475DFC04526	false	N6,N6-dimethyl-L-lysine:9-9	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P61830	intact:EBI-2650713	intact:EBI-8098|uniprotkb:E9PAG1|uniprotkb:P02303|uniprotkb:P13996|uniprotkb:Q6B1U3|uniprotkb:Q6Q7G9|uniprotkb:D6VQ11|ensemblfungi:YBR010W|ensemblfungi:YNL031C	-	psi-mi:h3_yeast(display_long)|uniprotkb:SIN2(gene name synonym)|uniprotkb:YNL031C(locus name)|uniprotkb:N2749(orf name)|uniprotkb:HHT1(gene name)|psi-mi:HHT1(display_short)|uniprotkb:YBR010W(locus name)|uniprotkb:YBR0201(orf name)|uniprotkb:HHT2(gene name)|psi-mi:HHT2(display_short)	psi-mi:cen-dg_spombe_dna(display_short)|psi-mi:EBI-2650713(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650857|imex:IM-13771-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_009564.1|refseq:NP_014367.1|sgd:S000000214|sgd:S000004976|mint:P61830|dip:DIP-417N|ensemblfungi:YBR010W(gene)|ensemblfungi:YBR010W_mRNA(transcript)|ensemblfungi:YNL031C(gene)|ensemblfungi:YNL031C_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043505"(CENP-A containing nucleosome)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1ID3|rcsb pdb:1M1D|rcsb pdb:1PEG|rcsb pdb:1PU9|rcsb pdb:1PUA|rcsb pdb:1QSN|rcsb pdb:2CNX|rcsb pdb:2H2G|rcsb pdb:2IDC|rcsb pdb:2JMJ|rcsb pdb:2RNW|rcsb pdb:2RNX|rcsb pdb:2RSN|rcsb pdb:3MP1|rcsb pdb:3MP6|rcsb pdb:3Q33|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:5D7E|rcsb pdb:5IOK|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6J2P|rcsb pdb:6KMJ|rcsb pdb:7K7G	-	-	crc64:A6115FEB480AC67A	comment:"In S. pombe, a broad distribution of heterochromatin is observed at pericentromeric regions, subtelomeres and the silent mating-type locus. These loci share a common feature: each contains dg and/or dh repeats that serve as RNA interference (RNAi)-dependent heterochromatin nucleation centres."	comment:"Anti-H3K9me2 chromatin immunoprecipitation (ChIP) on stc1-delta cells indicates that, as in dcr1-delta cells, H3K9me2 is only partially reduced on centromeric outer repeats (cen-dg) but is completely lost from the cen1:ura4+ marker gene. Consistent with this, a reduced level of Swi6 remains associated with outer repeats, but not with cen1:ura4+."|figure legend:Fig 1E, 6D.|comment:Interaction reduced in dcr-/- and stc1-/- cells and not observed  in clr4-/- cells.|comment:"H3K9me2 levels associated with cen(dg) in wild type, stc1-K100A, and stc1-R116A containing mutants. The K100A and R116A mutations reduce binding as does deletion of stc1."|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:jtDVNjrs2tJMmr/dqrvnNiQ2ppQ559292	-	intact-crc:64089F6A0EDAD357	false	N6,N6-dimethyl-L-lysine:9-9	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P61830	uniprotkb:O94276	intact:EBI-8098|uniprotkb:E9PAG1|uniprotkb:P02303|uniprotkb:P13996|uniprotkb:Q6B1U3|uniprotkb:Q6Q7G9|uniprotkb:D6VQ11|ensemblfungi:YBR010W|ensemblfungi:YNL031C	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	psi-mi:h3_yeast(display_long)|uniprotkb:SIN2(gene name synonym)|uniprotkb:YNL031C(locus name)|uniprotkb:N2749(orf name)|uniprotkb:HHT1(gene name)|psi-mi:HHT1(display_short)|uniprotkb:YBR010W(locus name)|uniprotkb:YBR0201(orf name)|uniprotkb:HHT2(gene name)|psi-mi:HHT2(display_short)	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650857|imex:IM-13771-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009564.1|refseq:NP_014367.1|sgd:S000000214|sgd:S000004976|mint:P61830|dip:DIP-417N|ensemblfungi:YBR010W(gene)|ensemblfungi:YBR010W_mRNA(transcript)|ensemblfungi:YNL031C(gene)|ensemblfungi:YNL031C_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043505"(CENP-A containing nucleosome)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1ID3|rcsb pdb:1M1D|rcsb pdb:1PEG|rcsb pdb:1PU9|rcsb pdb:1PUA|rcsb pdb:1QSN|rcsb pdb:2CNX|rcsb pdb:2H2G|rcsb pdb:2IDC|rcsb pdb:2JMJ|rcsb pdb:2RNW|rcsb pdb:2RNX|rcsb pdb:2RSN|rcsb pdb:3MP1|rcsb pdb:3MP6|rcsb pdb:3Q33|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:5D7E|rcsb pdb:5IOK|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6J2P|rcsb pdb:6KMJ|rcsb pdb:7K7G	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	-	crc64:A6115FEB480AC67A	-	comment:"Anti-H3K9me2 chromatin immunoprecipitation (ChIP) on stc1-delta cells indicates that, as in dcr1-delta cells, H3K9me2 is only partially reduced on centromeric outer repeats (cen-dg) but is completely lost from the cen1:ura4+ marker gene. Consistent with this, a reduced level of Swi6 remains associated with outer repeats, but not with cen1:ura4+."|figure legend:Fig 1E, 6D.|comment:Interaction reduced in dcr-/- and stc1-/- cells and not observed  in clr4-/- cells.|comment:"H3K9me2 levels associated with cen(dg) in wild type, stc1-K100A, and stc1-R116A containing mutants. The K100A and R116A mutations reduce binding as does deletion of stc1."|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:jtDVNjrs2tJMmr/dqrvnNiQ2ppQ559292	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	intact-crc:64089F6A0EDAD357	false	N6,N6-dimethyl-L-lysine:9-9	mutation decreasing interaction:100-100|mutation decreasing interaction:116-116	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40381	ddbj/embl/genbank:X66738	intact:EBI-926939|ensemblfungi:"SPAC664.01c.1:pep"	intact:EBI-2650833	psi-mi:swi6_schpo(display_long)|uniprotkb:swi6(gene name)|psi-mi:swi6(display_short)|uniprotkb:SPAC664.01c(orf name)|uniprotkb:SPAC824.10c(orf name)	psi-mi:"cen1:ura4_spomb_dna"(display_short)|psi-mi:X66738(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650903|imex:IM-13771-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_593449.1|dip:DIP-35736N|reactome:R-SPO-73772|reactome:R-SPO-983231|ensemblfungi:SPAC664.01c(gene)|ensemblfungi:SPAC664.01c.1(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006325"(chromatin organization)|go:"GO:0007533"(mating type switching)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033696"(heterochromatin boundary formation)|go:"GO:0034507"(chromosome, centromeric outer repeat region)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044820"(mitotic telomere tethering at nuclear periphery)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1E0B|rcsb pdb:2RSO	-	-	crc64:F505CC8AC5E75EAB	comment:ura4+ is a marker gene.	comment:"Anti-H3K9me2 chromatin immunoprecipitation (ChIP) on stc1-delta cells indicates that, as in dcr1-delta cells, H3K9me2 is only partially reduced on centromeric outer repeats (cen-dg) but is completely lost from the cen1:ura4+ marker gene. Consistent with this, a reduced level of Swi6 remains associated with outer repeats, but not with cen1:ura4+."|figure legend:Fig 1E.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:EEISpq3oLJ9jyNp6870DB1Z3xCY284812	-	intact-crc:E88AB0F93D9E7A17	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40381	intact:EBI-2650713	intact:EBI-926939|ensemblfungi:"SPAC664.01c.1:pep"	-	psi-mi:swi6_schpo(display_long)|uniprotkb:swi6(gene name)|psi-mi:swi6(display_short)|uniprotkb:SPAC664.01c(orf name)|uniprotkb:SPAC824.10c(orf name)	psi-mi:cen-dg_spombe_dna(display_short)|psi-mi:EBI-2650713(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650903|imex:IM-13771-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_593449.1|dip:DIP-35736N|reactome:R-SPO-73772|reactome:R-SPO-983231|ensemblfungi:SPAC664.01c(gene)|ensemblfungi:SPAC664.01c.1(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006325"(chromatin organization)|go:"GO:0007533"(mating type switching)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033696"(heterochromatin boundary formation)|go:"GO:0034507"(chromosome, centromeric outer repeat region)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044820"(mitotic telomere tethering at nuclear periphery)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1E0B|rcsb pdb:2RSO	-	-	crc64:F505CC8AC5E75EAB	comment:"In S. pombe, a broad distribution of heterochromatin is observed at pericentromeric regions, subtelomeres and the silent mating-type locus. These loci share a common feature: each contains dg and/or dh repeats that serve as RNA interference (RNAi)-dependent heterochromatin nucleation centres."	comment:"Anti-H3K9me2 chromatin immunoprecipitation (ChIP) on stc1-delta cells indicates that, as in dcr1-delta cells, H3K9me2 is only partially reduced on centromeric outer repeats (cen-dg) but is completely lost from the cen1:ura4+ marker gene. Consistent with this, a reduced level of Swi6 remains associated with outer repeats, but not with cen1:ura4+."|figure legend:Fig 1E.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:EEISpq3oLJ9jyNp6870DB1Z3xCY284812	-	intact-crc:E88AB0F93D9E7A17	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40381	intact:EBI-2650713	intact:EBI-926939|ensemblfungi:"SPAC664.01c.1:pep"	-	psi-mi:swi6_schpo(display_long)|uniprotkb:swi6(gene name)|psi-mi:swi6(display_short)|uniprotkb:SPAC664.01c(orf name)|uniprotkb:SPAC824.10c(orf name)	psi-mi:cen-dg_spombe_dna(display_short)|psi-mi:EBI-2650713(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650920|imex:IM-13771-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_593449.1|dip:DIP-35736N|reactome:R-SPO-73772|reactome:R-SPO-983231|ensemblfungi:SPAC664.01c(gene)|ensemblfungi:SPAC664.01c.1(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006325"(chromatin organization)|go:"GO:0007533"(mating type switching)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033696"(heterochromatin boundary formation)|go:"GO:0034507"(chromosome, centromeric outer repeat region)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044820"(mitotic telomere tethering at nuclear periphery)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1E0B|rcsb pdb:2RSO	-	-	crc64:F505CC8AC5E75EAB	comment:"In S. pombe, a broad distribution of heterochromatin is observed at pericentromeric regions, subtelomeres and the silent mating-type locus. These loci share a common feature: each contains dg and/or dh repeats that serve as RNA interference (RNAi)-dependent heterochromatin nucleation centres."	comment:"Anti-H3K9me2 chromatin immunoprecipitation (ChIP) on stc1-delta cells indicates that, as in dcr1-delta cells, H3K9me2 is only partially reduced on centromeric outer repeats (cen-dg) but is completely lost from the cen1:ura4+ marker gene. Consistent with this, a reduced level of Swi6 remains associated with outer repeats, but not with cen1:ura4+."|figure legend:Fig 1E.|comment:Interaction observed in STC-/- and DCR-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:EEISpq3oLJ9jyNp6870DB1Z3xCY284812	-	intact-crc:060C0F02DC8E3D33	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
ensemblgenomes:SPCC1322.13	uniprotkb:P61830	intact:EBI-2653334	intact:EBI-8098|uniprotkb:E9PAG1|uniprotkb:P02303|uniprotkb:P13996|uniprotkb:Q6B1U3|uniprotkb:Q6Q7G9|uniprotkb:D6VQ11|ensemblfungi:YBR010W|ensemblfungi:YNL031C	psi-mi:pur6_schpo_gene(display_short)|psi-mi:SPCC1322.13(display_long)	psi-mi:h3_yeast(display_long)|uniprotkb:SIN2(gene name synonym)|uniprotkb:YNL031C(locus name)|uniprotkb:N2749(orf name)|uniprotkb:HHT1(gene name)|psi-mi:HHT1(display_short)|uniprotkb:YBR010W(locus name)|uniprotkb:YBR0201(orf name)|uniprotkb:HHT2(gene name)|psi-mi:HHT2(display_short)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651889|imex:IM-13771-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009564.1|refseq:NP_014367.1|sgd:S000000214|sgd:S000004976|mint:P61830|dip:DIP-417N|ensemblfungi:YBR010W(gene)|ensemblfungi:YBR010W_mRNA(transcript)|ensemblfungi:YNL031C(gene)|ensemblfungi:YNL031C_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043505"(CENP-A containing nucleosome)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1ID3|rcsb pdb:1M1D|rcsb pdb:1PEG|rcsb pdb:1PU9|rcsb pdb:1PUA|rcsb pdb:1QSN|rcsb pdb:2CNX|rcsb pdb:2H2G|rcsb pdb:2IDC|rcsb pdb:2JMJ|rcsb pdb:2RNW|rcsb pdb:2RNX|rcsb pdb:2RSN|rcsb pdb:3MP1|rcsb pdb:3MP6|rcsb pdb:3Q33|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:5D7E|rcsb pdb:5IOK|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6J2P|rcsb pdb:6KMJ|rcsb pdb:7K7G	-	comment:codes for the enzyme phosphoribosylaminoimidazole carboxylase involved in purine biosynthesis. Ensembl fungi accession no =SPCC1322.13.	crc64:A6115FEB480AC67A	figure legend:Fig 2F, S5G, and 6F, 5F.|comment:"Stc1 is required for establishment of GBD-Clr4-Delta-cd (3xgbs-ade6+) mediated silencing, and ChIP analyses confirmed that establishment of H3K9me on the reporter required Stc1, whereas maintenance of H3K9me was largely unaffected in stc1-Delta cells."|comment:"Establishment of silencing by tethered Clr4 (3xgbs-ade6+), which requires Stc1, was unaffected by  Stc1 LIM domain mutations (K100A and K116A)."|caution:"The mutation on image S5G \"K116A\" is not mentioned anywhere else in the paper  and may refer to the mutation \"R116A\"."|comment:Recruitment of Stc1K100A or Stc1R116A to ade6+ by fusion to TetRoff resulted in H3K9 methylation and silencing.|comment:Interaction observed in stc1-/-, dcr-/-, ago-/-, chp1-/- and rdp1-/- cells but not clr4-/-, rik1-/-, dos1-/- or dos2-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	-	rogid:jtDVNjrs2tJMmr/dqrvnNiQ2ppQ559292	intact-crc:7B5D963796D8AF7B	false	-	N6,N6-dimethyl-L-lysine:9-9	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O94276	intact:EBI-2650713	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	-	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:cen-dg_spombe_dna(display_short)|psi-mi:EBI-2650713(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653145|imex:IM-13771-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	-	-	-	comment:"In S. pombe, a broad distribution of heterochromatin is observed at pericentromeric regions, subtelomeres and the silent mating-type locus. These loci share a common feature: each contains dg and/or dh repeats that serve as RNA interference (RNAi)-dependent heterochromatin nucleation centres."	comment:Stc1-FLAG associates with centromeric outer repeats, dependent on functional Dcr1 and Clr4.|figure legend:Fig 4B.|comment:Interaction is observed in clr3-/- cells but not in dcr-/- or clr4-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	-	intact-crc:041CA5B6B0CB8CB0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O94276	intact:EBI-2653158	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	-	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:mat_spombe_dna(display_short)|psi-mi:EBI-2653158(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653175|imex:IM-13771-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	-	-	-	-	comment:Dcr1- and Clr4-dependent enrichment of Stc1-FLAG at telomeres and mat2-mat3 was also detected by ChIP.|figure legend:Fig S4A.|comment:Interaction observed in Dcr-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	-	intact-crc:7970EC7DE7CFC95C	false	flag tag:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O94276	intact:EBI-2653184	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	-	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:tlh_schpo_genes(display_short)|psi-mi:EBI-2653184(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653185|imex:IM-13771-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	-	-	-	-	comment:Dcr1- and Clr4-dependent enrichment of Stc1-FLAG at telomeres and mat2-mat3 was also detected by ChIP.|figure legend:Fig S4A.|comment:Interaction not observed in clr4-/- cells and reduced in dcr1-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	-	intact-crc:1FBBDBBC73B074DC	false	flag tag:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
ensemblgenomes:SPCC330.05c	uniprotkb:O94276	intact:EBI-2653238	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	psi-mi:pyrf_schpo_gene(display_short)|psi-mi:SPCC330.05c(display_long)	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653223|imex:IM-13771-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	-	-	-	comment:"Stc1 fused to a TetRoff DNA-binding domain plus two FLAG tags (TetRoff-Stc1) was expressed in cells with four tet operators upstream of an ade6+ reporter (4xTetO-ade6+). This resulted in recruitment of TetRoff-Stc1 to the reporter and silencing of the ade6+ gene."|figure legend:Fig 5B.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	crc64:93DEFB197295E88E	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	intact-crc:473840606E4E076A	false	-	flag tag:?-?|fusion protein:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P61830	ensemblgenomes:SPCC1322.13	intact:EBI-8098|uniprotkb:E9PAG1|uniprotkb:P02303|uniprotkb:P13996|uniprotkb:Q6B1U3|uniprotkb:Q6Q7G9|uniprotkb:D6VQ11|ensemblfungi:YBR010W|ensemblfungi:YNL031C	intact:EBI-2653334	psi-mi:h3_yeast(display_long)|uniprotkb:SIN2(gene name synonym)|uniprotkb:YNL031C(locus name)|uniprotkb:N2749(orf name)|uniprotkb:HHT1(gene name)|psi-mi:HHT1(display_short)|uniprotkb:YBR010W(locus name)|uniprotkb:YBR0201(orf name)|uniprotkb:HHT2(gene name)|psi-mi:HHT2(display_short)	psi-mi:pur6_schpo_gene(display_short)|psi-mi:SPCC1322.13(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653260|imex:IM-13771-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_009564.1|refseq:NP_014367.1|sgd:S000000214|sgd:S000004976|mint:P61830|dip:DIP-417N|ensemblfungi:YBR010W(gene)|ensemblfungi:YBR010W_mRNA(transcript)|ensemblfungi:YNL031C(gene)|ensemblfungi:YNL031C_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0043505"(CENP-A containing nucleosome)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1ID3|rcsb pdb:1M1D|rcsb pdb:1PEG|rcsb pdb:1PU9|rcsb pdb:1PUA|rcsb pdb:1QSN|rcsb pdb:2CNX|rcsb pdb:2H2G|rcsb pdb:2IDC|rcsb pdb:2JMJ|rcsb pdb:2RNW|rcsb pdb:2RNX|rcsb pdb:2RSN|rcsb pdb:3MP1|rcsb pdb:3MP6|rcsb pdb:3Q33|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:5D7E|rcsb pdb:5IOK|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6J2P|rcsb pdb:6KMJ|rcsb pdb:7K7G	-	-	crc64:A6115FEB480AC67A	comment:codes for the enzyme phosphoribosylaminoimidazole carboxylase involved in purine biosynthesis. Ensembl fungi accession no =SPCC1322.13.	comment:"Tethered Stc1 (TetRoff-Stc1) induces H3K9 methylation over the reporter that is maintained in RNAi mutants but not in clr4-Delta, rik1-Delta, dos1-Delta, and dos2-Delta cells. (A 4xTetO-ade6+ reporter was used: 4xTetO repeats  were introduced upstream of ade6+ inserted at the ura4+ locus)."|figure legend:Fig 5F.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:jtDVNjrs2tJMmr/dqrvnNiQ2ppQ559292	-	intact-crc:3EEC2EE4C93CD617	false	N6,N6-dimethyl-L-lysine:9-9	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O94276	uniprotkb:O13802	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-1542450|ensemblfungi:"SPAC17H9.05.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:ebp2_schpo(display_long)|uniprotkb:ebp2(gene name)|psi-mi:ebp2(display_short)|uniprotkb:SPAC17H9.05(orf name)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	interpro:IPR008610(Eukaryotic rRNA processing)|refseq:NP_593575.1|mint:O13802|ensemblfungi:SPAC17H9.05(gene)|ensemblfungi:SPAC17H9.05.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042273"(ribosomal large subunit biogenesis)|reactome:R-SPO-6791226	psi-mi:"MI:0469"(intact)	-	-	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:SXj39Yj93oZTYLLxlI37hn0Hcf4284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O94276	uniprotkb:Q10426	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-1111936|uniprotkb:Q9USN9|uniprotkb:Q9UUL7|ensemblfungi:"SPCC11E10.08.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:rik1_schpo(display_long)|uniprotkb:rik1(gene name)|psi-mi:rik1(display_short)|uniprotkb:SPCC11E10.08(orf name)|uniprotkb:Silencing protein rik1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	refseq:NP_588204.1|ensemblfungi:SPCC11E10.08(gene)|ensemblfungi:SPCC11E10.08.1(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0006281"(DNA repair)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|dip:DIP-35634N	psi-mi:"MI:0469"(intact)	-	crc64:0C76BB59E1215BF1	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:t1LBwviHXmmvKSMrLCcs2QCSp2Q284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O94276	uniprotkb:O74560	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-904886|ensemblfungi:"SPCC970.07c.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:raf2_schpo(display_long)|uniprotkb:SPCC970.07c(orf name)|uniprotkb:Cryptic loci regulator 7(gene name synonym)|uniprotkb:De-localization of swi6 protein 2(gene name synonym)|uniprotkb:raf2(gene name)|psi-mi:raf2(display_short)|uniprotkb:clr7(gene name synonym)|uniprotkb:cmc2(gene name synonym)|uniprotkb:dos2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	refseq:NP_587848.1|dip:DIP-37848N|ensemblfungi:SPCC970.07c(gene)|ensemblfungi:SPCC970.07c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0043494"(CLRC complex)|go:"GO:1903097"(regulation of CENP-A containing nucleosome assembly)|go:"GO:1990342"(heterochromatin island)|interpro:IPR022702	psi-mi:"MI:0469"(intact)	-	crc64:C3FF8306DD764CFB	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:UWLnTfEq723O4+bqLXm/ZxkN6B4284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O94276	uniprotkb:Q10349	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-2652003|ensemblfungi:"SPAC1F12.07.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:serc_schpo(display_long)|uniprotkb:Phosphohydroxythreonine aminotransferase(gene name synonym)|uniprotkb:SPAC1F12.07(orf name)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	refseq:NP_594333.1|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR020578|interpro:IPR022278|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|ensemblfungi:SPAC1F12.07(gene)|ensemblfungi:SPAC1F12.07.1(transcript)|go:"GO:0004648"("O-phospho-L-serine:2-oxoglutarate aminotransferase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|reactome:R-SPO-977347	psi-mi:"MI:0469"(intact)	-	-	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:F8j4PZqvCKttDkNBtzty2STrXIQ284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O94276	uniprotkb:Q9P7S7	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-2651990|ensemblfungi:"SPAC23G3.06.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:nop58_schpo(display_long)|uniprotkb:nop58(gene name)|psi-mi:nop58(display_short)|uniprotkb:SPAC23G3.06(orf name)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|refseq:NP_593106.1|reactome:R-SPO-6791226|ensemblfungi:SPAC23G3.06(gene)|ensemblfungi:SPAC23G3.06.1(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0005634"(nucleus)|reactome:R-SPO-4570464|interpro:IPR042239|interpro:IPR036070	psi-mi:"MI:0469"(intact)	-	-	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:h9kO2ZeqMRQJ32haymxSgUH6iGU284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O94276	uniprotkb:O94514	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-2651974|ensemblfungi:"SPBC646.10c.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:nop56_schpo(display_long)|uniprotkb:nop56(gene name)|psi-mi:nop56(display_short)|uniprotkb:sik1(gene name synonym)|uniprotkb:Ribosome biosynthesis protein sik1(gene name synonym)|uniprotkb:SPBC646.10c(orf name)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|refseq:NP_595368.1|reactome:R-SPO-6791226|ensemblfungi:SPBC646.10c(gene)|ensemblfungi:SPBC646.10c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|interpro:IPR042239|interpro:IPR036070	psi-mi:"MI:0469"(intact)	-	-	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:Hu/M2zVwQXjKqz/jYCKWloYiGl8284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O94276	uniprotkb:O74752	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-2651951|ensemblfungi:"SPBC1734.11.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:mas5_schpo(display_long)|uniprotkb:mas5(gene name)|psi-mi:mas5(display_short)|uniprotkb:SPBC1734.11(orf name)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	refseq:NP_595428.1|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|ensemblfungi:SPBC1734.11(gene)|ensemblfungi:SPBC1734.11.1(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:0140453"(protein aggregate center)|go:"GO:0140454"(protein aggregate center assembly)|go:"GO:0140455"(cytoplasm protein quality control)|reactome:R-SPO-3371497|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713	psi-mi:"MI:0469"(intact)	-	-	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:iI6TLRUh5bTt+RDWGnH+o78M3mE284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O94276	uniprotkb:O74910	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-904913|ensemblfungi:"SPCC613.12c.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:raf1_schpo(display_long)|uniprotkb:SPCC613.12c(orf name)|uniprotkb:Cryptic loci regulator 8(gene name synonym)|uniprotkb:De-localization of swi6 protein 1(gene name synonym)|uniprotkb:raf1(gene name)|psi-mi:raf1(display_short)|uniprotkb:clr8(gene name synonym)|uniprotkb:cmc1(gene name synonym)|uniprotkb:dos1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	reactome:R-SPO-3214841|reactome:R-SPO-3214858|reactome:R-SPO-8951664|refseq:NP_587700.1|dip:DIP-37644N|ensemblfungi:SPCC613.12c(gene)|ensemblfungi:SPCC613.12c.1(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:1903097"(regulation of CENP-A containing nucleosome assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:4O9D	psi-mi:"MI:0469"(intact)	-	crc64:6CD360D8748AAF98	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:M62ohYAJUMwTxHiT117Bno2UG8c284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O94276	uniprotkb:O14122	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-904890|uniprotkb:Q9USB6|ensemblfungi:"SPAC3A11.08.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:cul4_schpo(display_long)|uniprotkb:pcu4(gene name)|psi-mi:pcu4(display_short)|uniprotkb:cul4(gene name synonym)|uniprotkb:SPAC3A11.08(orf name)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	reactome:R-SPO-5696395|reactome:R-SPO-5696400|reactome:R-SPO-6781823|reactome:R-SPO-6782135|reactome:R-SPO-6782210|interpro:IPR033044|refseq:NP_594195.1|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR019559|interpro:IPR016159(Cullin repeat-like)|reactome:R-SPO-110314|reactome:R-SPO-8951664|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|ensemblfungi:SPAC3A11.08(gene)|ensemblfungi:SPAC3A11.08.1(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033621"(nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043494"(CLRC complex)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)	psi-mi:"MI:0469"(intact)	-	-	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:gJJvtfEApiJnXSMsi9Mk0W3VjO0284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O94276	uniprotkb:O14399	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-2651928|ensemblfungi:"SPBC12D12.08c.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:ubl1_schpo(display_long)|uniprotkb:ubl1(gene name)|psi-mi:ubl1(display_short)|uniprotkb:ned8(gene name synonym)|uniprotkb:SPBC12D12.08c(orf name)|uniprotkb:SPBC24C6.01c(orf name)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2651924|imex:IM-13771-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	refseq:NP_595955.1|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|ensemblfungi:SPBC12D12.08c(gene)|ensemblfungi:SPBC12D12.08c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|reactome:R-SPO-8856825|interpro:IPR038738|reactome:R-SPO-5689603|reactome:R-SPO-8951664	psi-mi:"MI:0469"(intact)	-	-	comment:Proteins found specifically and reproducibly associated with Stc1-FLAG.|figure legend:Fig 3A.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:gnaHGY1w/9kLXz8PnGEDYVbaEGo284812	intact-crc:41D5F42E18971FCE|rigid:nqtqeoGvvtw2UpHeJbYS/ig+ZRk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O60016	uniprotkb:O94276	intact:EBI-354657|uniprotkb:O74565|ensemblfungi:"SPBC428.08c.1:pep"	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	psi-mi:clr4_schpo(display_long)|uniprotkb:clr4(gene name)|psi-mi:clr4(display_short)|uniprotkb:SPBC428.08c(orf name)|uniprotkb:kmt1(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase(gene name synonym)|uniprotkb:Cryptic loci regulator 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1(gene name synonym)|uniprotkb:Protein lysine methyltransferase clr4(gene name synonym)	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652030|imex:IM-13771-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595186.1|ensemblfungi:SPBC428.08c(gene)|ensemblfungi:SPBC428.08c.1(transcript)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0007535"(donor selection)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1902682"(protein localization to pericentric heterochromatin)|go:"GO:1903212"(protein localization to mating-type region heterochromatin)|interpro:IPR000953(Chromo domain)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR011381(Histone H3-K9 methyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1G6Z|rcsb pdb:1MVH|rcsb pdb:1MVX|rcsb pdb:6BOX|rcsb pdb:6BP4|dip:DIP-32588N	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	psi-mi:"MI:0469"(intact)	crc64:53C3EC87BCBA51FF	-	figure legend:Figs 3B/C and S3B.|comment:"Clr4, Rik1, and Dos2 associate with Stc1 even in the absence of RNAi. Association of Stc1-FLAG with the RITS component Ago1 (myc-Ago1) was also observed."|comment:Interaction observed in dcr-/- and ago1-/- cells but not in rik1-/-, raf1-/- or raf2-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:eUv/KQk3smVMRj/BSTYSDOw/vUY284812	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	intact-crc:6A6E755FC5516F1F|rigid:uVUIlocDKNySIEtQL4hLZM77AL8	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q10426	uniprotkb:O94276	intact:EBI-1111936|uniprotkb:Q9USN9|uniprotkb:Q9UUL7|ensemblfungi:"SPCC11E10.08.1:pep"	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	psi-mi:rik1_schpo(display_long)|uniprotkb:rik1(gene name)|psi-mi:rik1(display_short)|uniprotkb:SPCC11E10.08(orf name)|uniprotkb:Silencing protein rik1(gene name synonym)	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652097|imex:IM-13771-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588204.1|ensemblfungi:SPCC11E10.08(gene)|ensemblfungi:SPCC11E10.08.1(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0006281"(DNA repair)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|dip:DIP-35634N	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	psi-mi:"MI:0469"(intact)	crc64:0C76BB59E1215BF1	-	figure legend:Figs 3B/C and S3C.|comment:"Clr4, Rik1, and Dos2 associate with Stc1 even in the absence of RNAi. Association of Stc1-FLAG with the RITS component Ago1 (myc-Ago1) was also observed."|comment:Interaction observed in dcr-/-, clr4-/- and ago1-/- cells but not in raf1-/- or raf2-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:t1LBwviHXmmvKSMrLCcs2QCSp2Q284812	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	intact-crc:1AB2734D17367CFD|rigid:hMVwS4nNPrmrSgCL/vsg+FjuggY	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O74560	uniprotkb:O94276	intact:EBI-904886|ensemblfungi:"SPCC970.07c.1:pep"	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	psi-mi:raf2_schpo(display_long)|uniprotkb:SPCC970.07c(orf name)|uniprotkb:Cryptic loci regulator 7(gene name synonym)|uniprotkb:De-localization of swi6 protein 2(gene name synonym)|uniprotkb:raf2(gene name)|psi-mi:raf2(display_short)|uniprotkb:clr7(gene name synonym)|uniprotkb:cmc2(gene name synonym)|uniprotkb:dos2(gene name synonym)	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652117|imex:IM-13771-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_587848.1|dip:DIP-37848N|ensemblfungi:SPCC970.07c(gene)|ensemblfungi:SPCC970.07c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0043494"(CLRC complex)|go:"GO:1903097"(regulation of CENP-A containing nucleosome assembly)|go:"GO:1990342"(heterochromatin island)|interpro:IPR022702	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	psi-mi:"MI:0469"(intact)	crc64:C3FF8306DD764CFB	-	figure legend:Figs 3B/C and S3C.|comment:"Clr4, Rik1, and Dos2 associate with Stc1 even in the absence of RNAi. Association of Stc1-FLAG with the RITS component Ago1 (myc-Ago1) was also observed."|comment:Interaction was observed in dcr1-/-, clr4-/- and ago-/- cells but not in raf1-/- or rik1-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:UWLnTfEq723O4+bqLXm/ZxkN6B4284812	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	intact-crc:7F8DA4926C70A4FC|rigid:SvTZ7qTfD4tEZp3FJ5oUaNgqTOg	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O74957	uniprotkb:O94276	intact:EBI-422882|ensemblfungi:"SPCC736.11.1:pep"	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	psi-mi:ago1_schpo(display_long)|uniprotkb:Eukaryotic translation initiation factor 2C 2-like protein ago1(gene name synonym)|uniprotkb:PAZ Piwi domain protein ago1(gene name synonym)|uniprotkb:Cell cycle control protein ago1(gene name synonym)|uniprotkb:RNA interference pathway protein ago1(gene name synonym)|uniprotkb:ago1(gene name)|psi-mi:ago1(display_short)|uniprotkb:csp9(gene name synonym)|uniprotkb:SPCC736.11(orf name)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652133|imex:IM-13771-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_587782.1|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990431"(priRNA 3'-end processing)|go:"GO:1990432"(siRNA 3'-end processing)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|go:"GO:0070317"(negative regulation of G0 to G1 transition)|ensemblfungi:SPCC736.11(gene)|ensemblfungi:SPCC736.11.1(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030958"(RITS complex)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033167"(ARC complex)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0033562"(co-transcriptional gene silencing by RNA interference machinery)|go:"GO:0070314"(G1 to G0 transition)|dip:DIP-29298N|reactome:R-SPO-426486|reactome:R-SPO-426496|reactome:R-SPO-5578749	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	psi-mi:"MI:0469"(intact)	crc64:F5CE397BF590D9E4	-	figure legend:Figs 3B/C and S3D.|comment:"Clr4, Rik1, and Dos2 associate with Stc1 even in the absence of RNAi. Association of Stc1-FLAG with the RITS component Ago1 (myc-Ago1) was also observed."|comment:Interaction was not observed in clr4-/-, rik1-/-, raf1-/- and dcr1-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:3tKwgKbvZIpiJQ+BuEd7uOm1O6M284812	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	intact-crc:9FFCA7E3F799CE47|rigid:R364DhIeDIbv2zxo2VibItaeh+w	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O74957	uniprotkb:O60016	intact:EBI-422882|ensemblfungi:"SPCC736.11.1:pep"	intact:EBI-354657|uniprotkb:O74565|ensemblfungi:"SPBC428.08c.1:pep"	psi-mi:ago1_schpo(display_long)|uniprotkb:Eukaryotic translation initiation factor 2C 2-like protein ago1(gene name synonym)|uniprotkb:PAZ Piwi domain protein ago1(gene name synonym)|uniprotkb:Cell cycle control protein ago1(gene name synonym)|uniprotkb:RNA interference pathway protein ago1(gene name synonym)|uniprotkb:ago1(gene name)|psi-mi:ago1(display_short)|uniprotkb:csp9(gene name synonym)|uniprotkb:SPCC736.11(orf name)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:clr4_schpo(display_long)|uniprotkb:clr4(gene name)|psi-mi:clr4(display_short)|uniprotkb:SPBC428.08c(orf name)|uniprotkb:kmt1(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase(gene name synonym)|uniprotkb:Cryptic loci regulator 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1(gene name synonym)|uniprotkb:Protein lysine methyltransferase clr4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652314|imex:IM-13771-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_587782.1|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990431"(priRNA 3'-end processing)|go:"GO:1990432"(siRNA 3'-end processing)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|go:"GO:0070317"(negative regulation of G0 to G1 transition)|ensemblfungi:SPCC736.11(gene)|ensemblfungi:SPCC736.11.1(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030958"(RITS complex)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033167"(ARC complex)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0033562"(co-transcriptional gene silencing by RNA interference machinery)|go:"GO:0070314"(G1 to G0 transition)|dip:DIP-29298N|reactome:R-SPO-426486|reactome:R-SPO-426496|reactome:R-SPO-5578749	refseq:NP_595186.1|ensemblfungi:SPBC428.08c(gene)|ensemblfungi:SPBC428.08c.1(transcript)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0007535"(donor selection)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1902682"(protein localization to pericentric heterochromatin)|go:"GO:1903212"(protein localization to mating-type region heterochromatin)|interpro:IPR000953(Chromo domain)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR011381(Histone H3-K9 methyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1G6Z|rcsb pdb:1MVH|rcsb pdb:1MVX|rcsb pdb:6BOX|rcsb pdb:6BP4|dip:DIP-32588N	psi-mi:"MI:0469"(intact)	crc64:F5CE397BF590D9E4	crc64:53C3EC87BCBA51FF	figure legend:Figs 3D.|comment:Clr4 association with Ago1 requires Stc1.|comment:Weak interaction not observed in stc1-/- or dcr1-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:3tKwgKbvZIpiJQ+BuEd7uOm1O6M284812	rogid:eUv/KQk3smVMRj/BSTYSDOw/vUY284812	intact-crc:0B3097B431A39BEA|rigid:XNj5FtlYkKRb9e96/pXQBTv17cE	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O74910	uniprotkb:O94276	intact:EBI-904913|ensemblfungi:"SPCC613.12c.1:pep"	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	psi-mi:raf1_schpo(display_long)|uniprotkb:SPCC613.12c(orf name)|uniprotkb:Cryptic loci regulator 8(gene name synonym)|uniprotkb:De-localization of swi6 protein 1(gene name synonym)|uniprotkb:raf1(gene name)|psi-mi:raf1(display_short)|uniprotkb:clr8(gene name synonym)|uniprotkb:cmc1(gene name synonym)|uniprotkb:dos1(gene name synonym)	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652356|imex:IM-13771-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-SPO-3214841|reactome:R-SPO-3214858|reactome:R-SPO-8951664|refseq:NP_587700.1|dip:DIP-37644N|ensemblfungi:SPCC613.12c(gene)|ensemblfungi:SPCC613.12c.1(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:1903097"(regulation of CENP-A containing nucleosome assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:4O9D	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	psi-mi:"MI:0469"(intact)	crc64:6CD360D8748AAF98	-	figure legend:Figs S3C.|comment:"Clr4, Rik1, and Dos2 associate with Stc1 even in the absence of RNAi. Association of Stc1-FLAG with the RITS component Ago1 (myc-Ago1) was also observed."|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:M62ohYAJUMwTxHiT117Bno2UG8c284812	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	intact-crc:BD388256A35CAA8F|rigid:6t0Xq39v/dCYppzFWcVX4JzpFwA	false	green fluorescent protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q10103	uniprotkb:O14227	intact:EBI-421832|ensemblfungi:"SPAC18G6.02c.1:pep"	intact:EBI-2652374|ensemblfungi:"SPAC6F12.09.1:pep"	psi-mi:chp1_schpo(display_long)|uniprotkb:chp1(gene name)|psi-mi:chp1(display_short)|uniprotkb:SPAC18G6.02c(orf name)	psi-mi:rdp1_schpo(display_long)|uniprotkb:rdp1(gene name)|psi-mi:rdp1(display_short)|uniprotkb:csp7(gene name synonym)|uniprotkb:rdr1(gene name synonym)|uniprotkb:SPAC6F12.09(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652398|imex:IM-13771-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_593666.1|ensemblfungi:SPAC18G6.02c(gene)|ensemblfungi:SPAC18G6.02c.1(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030958"(RITS complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0034507"(chromosome, centromeric outer repeat region)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035064"(methylated histone binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|interpro:IPR000953(Chromo domain)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|interpro:IPR035979|rcsb pdb:2RSN|rcsb pdb:3G7L|rcsb pdb:3TIX|dip:DIP-29301N|reactome:R-SPO-73772|reactome:R-SPO-983231	refseq:NP_593295.1|ensemblfungi:SPAC6F12.09(gene)|ensemblfungi:SPAC6F12.09.1(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031380"(nuclear RNA-directed RNA polymerase complex)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033562"(co-transcriptional gene silencing by RNA interference machinery)|go:"GO:0034613"(cellular protein localization)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0070919"(production of siRNA involved in gene silencing by small RNA)|go:"GO:0099115"(chromosome, subtelomeric region)|interpro:IPR007855(RNA-dependent RNA polymerase, eukaryotic-type)|dip:DIP-57038N	psi-mi:"MI:0469"(intact)	crc64:E92C16BBD0D5957C	crc64:389B95C8217CB05C	figure legend:Figs  S3F.|comment:The association of Rdp1 with Chp1 depends on Stc1 and Dcr1.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:52dapo2Xglte9lzhLJh120xLS/g284812	rogid:PEEB/ttBEmQmIeCKFl5a1VGNvUE284812	intact-crc:8D1791E280E22CEE|rigid:JGJ+U+A5iObvCsyOSdgb/xJjVz4	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q10426	uniprotkb:O74910	intact:EBI-1111936|uniprotkb:Q9USN9|uniprotkb:Q9UUL7|ensemblfungi:"SPCC11E10.08.1:pep"	intact:EBI-904913|ensemblfungi:"SPCC613.12c.1:pep"	psi-mi:rik1_schpo(display_long)|uniprotkb:rik1(gene name)|psi-mi:rik1(display_short)|uniprotkb:SPCC11E10.08(orf name)|uniprotkb:Silencing protein rik1(gene name synonym)	psi-mi:raf1_schpo(display_long)|uniprotkb:SPCC613.12c(orf name)|uniprotkb:Cryptic loci regulator 8(gene name synonym)|uniprotkb:De-localization of swi6 protein 1(gene name synonym)|uniprotkb:raf1(gene name)|psi-mi:raf1(display_short)|uniprotkb:clr8(gene name synonym)|uniprotkb:cmc1(gene name synonym)|uniprotkb:dos1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652408|imex:IM-13771-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588204.1|ensemblfungi:SPCC11E10.08(gene)|ensemblfungi:SPCC11E10.08.1(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0006281"(DNA repair)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|dip:DIP-35634N	reactome:R-SPO-3214841|reactome:R-SPO-3214858|reactome:R-SPO-8951664|refseq:NP_587700.1|dip:DIP-37644N|ensemblfungi:SPCC613.12c(gene)|ensemblfungi:SPCC613.12c.1(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:1903097"(regulation of CENP-A containing nucleosome assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:4O9D	psi-mi:"MI:0469"(intact)	crc64:0C76BB59E1215BF1	crc64:6CD360D8748AAF98	figure legend:Fig  S3G.|comment:Interactions between CLRC components are unaffected by deletion of Stc1.|comment:Interaction observed in Stc1-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:t1LBwviHXmmvKSMrLCcs2QCSp2Q284812	rogid:M62ohYAJUMwTxHiT117Bno2UG8c284812	intact-crc:DD57669E2FD17927|rigid:7So5MNzi8m4GGI8NT2/p/RWwoEk	false	flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O74560	uniprotkb:O74910	intact:EBI-904886|ensemblfungi:"SPCC970.07c.1:pep"	intact:EBI-904913|ensemblfungi:"SPCC613.12c.1:pep"	psi-mi:raf2_schpo(display_long)|uniprotkb:SPCC970.07c(orf name)|uniprotkb:Cryptic loci regulator 7(gene name synonym)|uniprotkb:De-localization of swi6 protein 2(gene name synonym)|uniprotkb:raf2(gene name)|psi-mi:raf2(display_short)|uniprotkb:clr7(gene name synonym)|uniprotkb:cmc2(gene name synonym)|uniprotkb:dos2(gene name synonym)	psi-mi:raf1_schpo(display_long)|uniprotkb:SPCC613.12c(orf name)|uniprotkb:Cryptic loci regulator 8(gene name synonym)|uniprotkb:De-localization of swi6 protein 1(gene name synonym)|uniprotkb:raf1(gene name)|psi-mi:raf1(display_short)|uniprotkb:clr8(gene name synonym)|uniprotkb:cmc1(gene name synonym)|uniprotkb:dos1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652457|imex:IM-13771-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_587848.1|dip:DIP-37848N|ensemblfungi:SPCC970.07c(gene)|ensemblfungi:SPCC970.07c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0043494"(CLRC complex)|go:"GO:1903097"(regulation of CENP-A containing nucleosome assembly)|go:"GO:1990342"(heterochromatin island)|interpro:IPR022702	reactome:R-SPO-3214841|reactome:R-SPO-3214858|reactome:R-SPO-8951664|refseq:NP_587700.1|dip:DIP-37644N|ensemblfungi:SPCC613.12c(gene)|ensemblfungi:SPCC613.12c.1(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:1903097"(regulation of CENP-A containing nucleosome assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:4O9D	psi-mi:"MI:0469"(intact)	crc64:C3FF8306DD764CFB	crc64:6CD360D8748AAF98	figure legend:Fig  S3G.|comment:Interactions between CLRC components are unaffected by deletion of Stc1.|comment:Interaction oberved in stc1-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:UWLnTfEq723O4+bqLXm/ZxkN6B4284812	rogid:M62ohYAJUMwTxHiT117Bno2UG8c284812	intact-crc:C8E1796E0969351D|rigid:dAaJUE5LQ78dgPbhAR6NnXb1N6k	false	flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O94276	uniprotkb:Q10426	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-1111936|uniprotkb:Q9USN9|uniprotkb:Q9UUL7|ensemblfungi:"SPCC11E10.08.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:rik1_schpo(display_long)|uniprotkb:rik1(gene name)|psi-mi:rik1(display_short)|uniprotkb:SPCC11E10.08(orf name)|uniprotkb:Silencing protein rik1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653823|imex:IM-13771-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	refseq:NP_588204.1|ensemblfungi:SPCC11E10.08(gene)|ensemblfungi:SPCC11E10.08.1(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0006281"(DNA repair)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|dip:DIP-35634N	psi-mi:"MI:0469"(intact)	-	crc64:0C76BB59E1215BF1	figure legend:Fig 6E.|comment:IP-western analyses indicated that both Stc1K100A and Stc1R116A proteins still associate with Clr4, Rik1 and Dos2, indicating that LIM domain mutations do not affect Stc1-CLRC interactions. In contrast, we could not detect association of Stc1K100A or Stc1R116A proteins with Ago1.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:t1LBwviHXmmvKSMrLCcs2QCSp2Q284812	intact-crc:41C5CA183A4F0928|rigid:5Tz88tARmGaF4v/62u6+DwYNnrI	false	flag tag:?-?|mutation:116-116	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O94276	uniprotkb:O74560	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-904886|ensemblfungi:"SPCC970.07c.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:raf2_schpo(display_long)|uniprotkb:SPCC970.07c(orf name)|uniprotkb:Cryptic loci regulator 7(gene name synonym)|uniprotkb:De-localization of swi6 protein 2(gene name synonym)|uniprotkb:raf2(gene name)|psi-mi:raf2(display_short)|uniprotkb:clr7(gene name synonym)|uniprotkb:cmc2(gene name synonym)|uniprotkb:dos2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653823|imex:IM-13771-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	refseq:NP_587848.1|dip:DIP-37848N|ensemblfungi:SPCC970.07c(gene)|ensemblfungi:SPCC970.07c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0043494"(CLRC complex)|go:"GO:1903097"(regulation of CENP-A containing nucleosome assembly)|go:"GO:1990342"(heterochromatin island)|interpro:IPR022702	psi-mi:"MI:0469"(intact)	-	crc64:C3FF8306DD764CFB	figure legend:Fig 6E.|comment:IP-western analyses indicated that both Stc1K100A and Stc1R116A proteins still associate with Clr4, Rik1 and Dos2, indicating that LIM domain mutations do not affect Stc1-CLRC interactions. In contrast, we could not detect association of Stc1K100A or Stc1R116A proteins with Ago1.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:UWLnTfEq723O4+bqLXm/ZxkN6B4284812	intact-crc:41C5CA183A4F0928|rigid:5Tz88tARmGaF4v/62u6+DwYNnrI	false	flag tag:?-?|mutation:116-116	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O94276	uniprotkb:O60016	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-354657|uniprotkb:O74565|ensemblfungi:"SPBC428.08c.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:clr4_schpo(display_long)|uniprotkb:clr4(gene name)|psi-mi:clr4(display_short)|uniprotkb:SPBC428.08c(orf name)|uniprotkb:kmt1(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase(gene name synonym)|uniprotkb:Cryptic loci regulator 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1(gene name synonym)|uniprotkb:Protein lysine methyltransferase clr4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653823|imex:IM-13771-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	refseq:NP_595186.1|ensemblfungi:SPBC428.08c(gene)|ensemblfungi:SPBC428.08c.1(transcript)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0007535"(donor selection)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1902682"(protein localization to pericentric heterochromatin)|go:"GO:1903212"(protein localization to mating-type region heterochromatin)|interpro:IPR000953(Chromo domain)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR011381(Histone H3-K9 methyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1G6Z|rcsb pdb:1MVH|rcsb pdb:1MVX|rcsb pdb:6BOX|rcsb pdb:6BP4|dip:DIP-32588N	psi-mi:"MI:0469"(intact)	-	crc64:53C3EC87BCBA51FF	figure legend:Fig 6E.|comment:IP-western analyses indicated that both Stc1K100A and Stc1R116A proteins still associate with Clr4, Rik1 and Dos2, indicating that LIM domain mutations do not affect Stc1-CLRC interactions. In contrast, we could not detect association of Stc1K100A or Stc1R116A proteins with Ago1.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:eUv/KQk3smVMRj/BSTYSDOw/vUY284812	intact-crc:41C5CA183A4F0928|rigid:5Tz88tARmGaF4v/62u6+DwYNnrI	false	flag tag:?-?|mutation:116-116	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O94276	uniprotkb:O74957	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	intact:EBI-422882|ensemblfungi:"SPCC736.11.1:pep"	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:ago1_schpo(display_long)|uniprotkb:Eukaryotic translation initiation factor 2C 2-like protein ago1(gene name synonym)|uniprotkb:PAZ Piwi domain protein ago1(gene name synonym)|uniprotkb:Cell cycle control protein ago1(gene name synonym)|uniprotkb:RNA interference pathway protein ago1(gene name synonym)|uniprotkb:ago1(gene name)|psi-mi:ago1(display_short)|uniprotkb:csp9(gene name synonym)|uniprotkb:SPCC736.11(orf name)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652491|imex:IM-13771-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	refseq:NP_587782.1|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990431"(priRNA 3'-end processing)|go:"GO:1990432"(siRNA 3'-end processing)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|go:"GO:0070317"(negative regulation of G0 to G1 transition)|ensemblfungi:SPCC736.11(gene)|ensemblfungi:SPCC736.11.1(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030958"(RITS complex)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033167"(ARC complex)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0033562"(co-transcriptional gene silencing by RNA interference machinery)|go:"GO:0070314"(G1 to G0 transition)|dip:DIP-29298N|reactome:R-SPO-426486|reactome:R-SPO-426496|reactome:R-SPO-5578749	psi-mi:"MI:0469"(intact)	-	crc64:F5CE397BF590D9E4	figure legend:Fig S3H.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/04/29	2014/10/16	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	rogid:3tKwgKbvZIpiJQ+BuEd7uOm1O6M284812	intact-crc:E28BA412694F660A|rigid:R364DhIeDIbv2zxo2VibItaeh+w	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9Y812	uniprotkb:O94276	intact:EBI-1153281|ensemblfungi:"SPBC1105.17.1:pep"	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	psi-mi:cenpa_schpo(display_long)|uniprotkb:cnp1(gene name)|psi-mi:cnp1(display_short)|uniprotkb:sim2(gene name synonym)|uniprotkb:SPBC1105.17(orf name)|uniprotkb:CENP-A homolog(gene name synonym)|uniprotkb:Silencing in the middle of the centromere protein 2(gene name synonym)	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652563|imex:IM-13771-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_596473.1|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|ensemblfungi:SPBC1105.17(gene)|ensemblfungi:SPBC1105.17.1(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0043505"(CENP-A containing nucleosome)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061638"(CENP-A containing chromatin)|go:"GO:0061641"(CENP-A containing chromatin organization)|go:"GO:1990758"(mitotic sister chromatid biorientation)|reactome:R-SPO-2299718|reactome:R-SPO-2559580|reactome:R-SPO-3214841|reactome:R-SPO-3214842|reactome:R-SPO-3214847|reactome:R-SPO-3214858|reactome:R-SPO-5578749|reactome:R-SPO-5693565|reactome:R-SPO-73772|reactome:R-SPO-983231	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	go:"GO:0000775"(chromosome, centromeric region)	-	-	comment:"Stc1-GFP and CENP-A/Cnp1 (centromere-specific H3 variant) costaining revealed one bright Stc1 focus in close proximity to the CENP-ACnp1 signal, suggesting that Stc1 primarily localizes at centromeres."|figure legend:Fig 4A.|comment:Colocalisation not observed in dcr-/- or clr4-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:AaYRJN1kS2Cf0jiTUDE0EIsDFJw284812	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	intact-crc:9B7467D512E801EB|rigid:SEvJfoQt9hWXmq0ZHzXChU1bSVo	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-2653118	uniprotkb:O94276	-	intact:EBI-2651917|ensemblfungi:"SPBP8B7.28c.1:pep"	psi-mi:cen-dg_spombe_rna(display_short)|psi-mi:EBI-2653118(display_long)	psi-mi:yors_schpo(display_long)|uniprotkb:SPBP8B7.28c(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653068|imex:IM-13771-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0320"(ribonucleic acid)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:2LUY|interpro:IPR024630|refseq:NP_596535.1|ensemblfungi:SPBP8B7.28c(gene)|ensemblfungi:SPBP8B7.28c.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR043069	-	comment:"In S. pombe, a broad distribution of heterochromatin is observed at pericentromeric regions, subtelomeres and the silent mating-type locus. These loci share a common feature: each contains dg and/or dh repeats that serve as RNA interference (RNAi)-dependent heterochromatin nucleation centres."	-	comment:"Centromeric outer repeat (dg) transcripts were enriched relative to act1+ gene transcripts in Rik1-FLAG IPs,  Stc1-FLAG and FLAG-Ago1 IPs.  The association of Stc1-FLAG with outer repeat transcripts was dependent on Dcr1 and Ago1.  Stc1 IPs consistently showed greater enrichment for centromeric transcripts than IPs of other CLRC components."|figure legend:Fig 4D/E and S4B.|comment:Interaction not observed in dcr-/- or ago-/- cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	-	rogid:92ZNuEqF8CMmIwO490VpSvn81xw284812	intact-crc:7ED73367C54A69ED	false	-	flag tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q10426	intact:EBI-2653118	intact:EBI-1111936|uniprotkb:Q9USN9|uniprotkb:Q9UUL7|ensemblfungi:"SPCC11E10.08.1:pep"	-	psi-mi:rik1_schpo(display_long)|uniprotkb:rik1(gene name)|psi-mi:rik1(display_short)|uniprotkb:SPCC11E10.08(orf name)|uniprotkb:Silencing protein rik1(gene name synonym)	psi-mi:cen-dg_spombe_rna(display_short)|psi-mi:EBI-2653118(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653075|imex:IM-13771-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	refseq:NP_588204.1|ensemblfungi:SPCC11E10.08(gene)|ensemblfungi:SPCC11E10.08.1(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0006281"(DNA repair)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0043494"(CLRC complex)|go:"GO:0045141"(meiotic telomere clustering)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|dip:DIP-35634N	-	-	crc64:0C76BB59E1215BF1	comment:"In S. pombe, a broad distribution of heterochromatin is observed at pericentromeric regions, subtelomeres and the silent mating-type locus. These loci share a common feature: each contains dg and/or dh repeats that serve as RNA interference (RNAi)-dependent heterochromatin nucleation centres."	comment:"Centromeric outer repeat (dg) transcripts were enriched relative to act1+ gene transcripts in Rik1-FLAG IPs,  Stc1-FLAG and FLAG-Ago1 IPs.  The association of Stc1-FLAG with outer repeat transcripts was dependent on Dcr1 and Ago1."|figure legend:Fig 4D/E.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	rogid:t1LBwviHXmmvKSMrLCcs2QCSp2Q284812	-	intact-crc:A34F12D635FB0ADD	false	flag tag:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-2653118	uniprotkb:O74957	-	intact:EBI-422882|ensemblfungi:"SPCC736.11.1:pep"	psi-mi:cen-dg_spombe_rna(display_short)|psi-mi:EBI-2653118(display_long)	psi-mi:ago1_schpo(display_long)|uniprotkb:Eukaryotic translation initiation factor 2C 2-like protein ago1(gene name synonym)|uniprotkb:PAZ Piwi domain protein ago1(gene name synonym)|uniprotkb:Cell cycle control protein ago1(gene name synonym)|uniprotkb:RNA interference pathway protein ago1(gene name synonym)|uniprotkb:ago1(gene name)|psi-mi:ago1(display_short)|uniprotkb:csp9(gene name synonym)|uniprotkb:SPCC736.11(orf name)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bayne et al. (2010)	imex:IM-13771|pubmed:20211136	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653083|imex:IM-13771-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0320"(ribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_587782.1|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990431"(priRNA 3'-end processing)|go:"GO:1990432"(siRNA 3'-end processing)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|go:"GO:0070317"(negative regulation of G0 to G1 transition)|ensemblfungi:SPCC736.11(gene)|ensemblfungi:SPCC736.11.1(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016891"(endoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030958"(RITS complex)|go:"GO:0031048"(heterochromatin assembly by small RNA)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033167"(ARC complex)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0033562"(co-transcriptional gene silencing by RNA interference machinery)|go:"GO:0070314"(G1 to G0 transition)|dip:DIP-29298N|reactome:R-SPO-426486|reactome:R-SPO-426496|reactome:R-SPO-5578749	-	comment:"In S. pombe, a broad distribution of heterochromatin is observed at pericentromeric regions, subtelomeres and the silent mating-type locus. These loci share a common feature: each contains dg and/or dh repeats that serve as RNA interference (RNAi)-dependent heterochromatin nucleation centres."	crc64:F5CE397BF590D9E4	comment:"Centromeric outer repeat (dg) transcripts were enriched relative to act1+ gene transcripts in Rik1-FLAG IPs,  Stc1-FLAG and FLAG-Ago1 IPs.  The association of Stc1-FLAG with outer repeat transcripts was dependent on Dcr1 and Ago1."|figure legend:Fig 4D/E.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2010/04/29	2014/10/16	-	rogid:3tKwgKbvZIpiJQ+BuEd7uOm1O6M284812	intact-crc:6C2E9160FD07560C	false	-	flag tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)