#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96PP8 uniprotkb:Q96PP8 intact:EBI-749932|uniprotkb:B2RCE1|uniprotkb:Q86TM5|ensembl:ENSP00000359488 intact:EBI-749932|uniprotkb:B2RCE1|uniprotkb:Q86TM5|ensembl:ENSP00000359488 psi-mi:gbp5_human(display_long)|uniprotkb:Guanine nucleotide-binding protein 5(gene name synonym)|uniprotkb:GTP-binding protein 5(gene name synonym)|uniprotkb:GBP-TA antigen(gene name synonym)|uniprotkb:GBP5(gene name)|psi-mi:GBP5(display_short)|uniprotkb:UNQ2427/PRO4987(orf name) psi-mi:gbp5_human(display_long)|uniprotkb:Guanine nucleotide-binding protein 5(gene name synonym)|uniprotkb:GTP-binding protein 5(gene name synonym)|uniprotkb:GBP-TA antigen(gene name synonym)|uniprotkb:GBP5(gene name)|psi-mi:GBP5(display_short)|uniprotkb:UNQ2427/PRO4987(orf name) psi-mi:"MI:0071"(molecular sieving) Wehner et al. (2010) pubmed:20180847|imex:IM-15651|mint:MINT-7555023|doi:10.1111/j.1742-4658.2010.07586 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7823837|mint:MINT-7555044|imex:IM-15651-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001127958.1|refseq:NP_443174.1|ensembl:ENSG00000154451(gene)|ensembl:ENST00000370459(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|mint:Q96PP8|rcsb pdb:7CKF|rcsb pdb:7E59|rcsb pdb:7E5A|reactome:R-HSA-877300|interpro:IPR015894(Guanylate-binding protein, N-terminal)|mint:MINT-7555046(identity) refseq:NP_001127958.1|refseq:NP_443174.1|ensembl:ENSG00000154451(gene)|ensembl:ENST00000370459(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|mint:Q96PP8|rcsb pdb:7CKF|rcsb pdb:7E59|rcsb pdb:7E5A|reactome:R-HSA-877300|interpro:IPR015894(Guanylate-binding protein, N-terminal)|mint:MINT-7555046(identity) - comment:"Stoichiometry: 4.0" comment:"Stoichiometry: 4.0" figure legend:f5a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/19 2014/10/16 rogid:oeKbs0b2DOTZqVLfDuJKrH6tua89606 rogid:oeKbs0b2DOTZqVLfDuJKrH6tua89606 intact-crc:1B72B9D8BFB63A17|rigid:fU8rQq8UmxG5Zi49ZbvvxnBWZzE false - - 4 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96PP8 uniprotkb:Q96PP8 intact:EBI-749932|uniprotkb:B2RCE1|uniprotkb:Q86TM5|ensembl:ENSP00000359488 intact:EBI-749932|uniprotkb:B2RCE1|uniprotkb:Q86TM5|ensembl:ENSP00000359488 psi-mi:gbp5_human(display_long)|uniprotkb:Guanine nucleotide-binding protein 5(gene name synonym)|uniprotkb:GTP-binding protein 5(gene name synonym)|uniprotkb:GBP-TA antigen(gene name synonym)|uniprotkb:GBP5(gene name)|psi-mi:GBP5(display_short)|uniprotkb:UNQ2427/PRO4987(orf name) psi-mi:gbp5_human(display_long)|uniprotkb:Guanine nucleotide-binding protein 5(gene name synonym)|uniprotkb:GTP-binding protein 5(gene name synonym)|uniprotkb:GBP-TA antigen(gene name synonym)|uniprotkb:GBP5(gene name)|psi-mi:GBP5(display_short)|uniprotkb:UNQ2427/PRO4987(orf name) psi-mi:"MI:0071"(molecular sieving) Wehner et al. (2010) pubmed:20180847|imex:IM-15651|mint:MINT-7555023|doi:10.1111/j.1742-4658.2010.07586 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7823817|mint:MINT-7555028|imex:IM-15651-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001127958.1|refseq:NP_443174.1|ensembl:ENSG00000154451(gene)|ensembl:ENST00000370459(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|mint:Q96PP8|rcsb pdb:7CKF|rcsb pdb:7E59|rcsb pdb:7E5A|reactome:R-HSA-877300|interpro:IPR015894(Guanylate-binding protein, N-terminal)|mint:MINT-7555030(identity) refseq:NP_001127958.1|refseq:NP_443174.1|ensembl:ENSG00000154451(gene)|ensembl:ENST00000370459(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|mint:Q96PP8|rcsb pdb:7CKF|rcsb pdb:7E59|rcsb pdb:7E5A|reactome:R-HSA-877300|interpro:IPR015894(Guanylate-binding protein, N-terminal)|mint:MINT-7555030(identity) - comment:"Stoichiometry: 2.0" comment:"Stoichiometry: 2.0" figure legend:f5a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/19 2014/10/16 rogid:oeKbs0b2DOTZqVLfDuJKrH6tua89606 rogid:oeKbs0b2DOTZqVLfDuJKrH6tua89606 intact-crc:8122A5C20AFFEFEC|rigid:fU8rQq8UmxG5Zi49ZbvvxnBWZzE false - - 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96PP8 uniprotkb:Q96PP8 intact:EBI-749932|uniprotkb:B2RCE1|uniprotkb:Q86TM5|ensembl:ENSP00000359488 intact:EBI-749932|uniprotkb:B2RCE1|uniprotkb:Q86TM5|ensembl:ENSP00000359488 psi-mi:gbp5_human(display_long)|uniprotkb:Guanine nucleotide-binding protein 5(gene name synonym)|uniprotkb:GTP-binding protein 5(gene name synonym)|uniprotkb:GBP-TA antigen(gene name synonym)|uniprotkb:GBP5(gene name)|psi-mi:GBP5(display_short)|uniprotkb:UNQ2427/PRO4987(orf name) psi-mi:gbp5_human(display_long)|uniprotkb:Guanine nucleotide-binding protein 5(gene name synonym)|uniprotkb:GTP-binding protein 5(gene name synonym)|uniprotkb:GBP-TA antigen(gene name synonym)|uniprotkb:GBP5(gene name)|psi-mi:GBP5(display_short)|uniprotkb:UNQ2427/PRO4987(orf name) psi-mi:"MI:0071"(molecular sieving) Wehner et al. (2010) pubmed:20180847|imex:IM-15651|mint:MINT-7555023|doi:10.1111/j.1742-4658.2010.07586 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7823827|mint:MINT-7555035|imex:IM-15651-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001127958.1|refseq:NP_443174.1|ensembl:ENSG00000154451(gene)|ensembl:ENST00000370459(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|mint:Q96PP8|rcsb pdb:7CKF|rcsb pdb:7E59|rcsb pdb:7E5A|reactome:R-HSA-877300|interpro:IPR015894(Guanylate-binding protein, N-terminal)|mint:MINT-7555037(identity) refseq:NP_001127958.1|refseq:NP_443174.1|ensembl:ENSG00000154451(gene)|ensembl:ENST00000370459(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|mint:Q96PP8|rcsb pdb:7CKF|rcsb pdb:7E59|rcsb pdb:7E5A|reactome:R-HSA-877300|interpro:IPR015894(Guanylate-binding protein, N-terminal)|mint:MINT-7555037(identity) - comment:"Stoichiometry: 2.0" comment:"Stoichiometry: 2.0" figure legend:f5b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/19 2014/10/16 rogid:oeKbs0b2DOTZqVLfDuJKrH6tua89606 rogid:oeKbs0b2DOTZqVLfDuJKrH6tua89606 intact-crc:81682A56BD1B2872|rigid:fU8rQq8UmxG5Zi49ZbvvxnBWZzE false - - 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96PP8 uniprotkb:Q96PP8 intact:EBI-749932|uniprotkb:B2RCE1|uniprotkb:Q86TM5|ensembl:ENSP00000359488 intact:EBI-749932|uniprotkb:B2RCE1|uniprotkb:Q86TM5|ensembl:ENSP00000359488 psi-mi:gbp5_human(display_long)|uniprotkb:Guanine nucleotide-binding protein 5(gene name synonym)|uniprotkb:GTP-binding protein 5(gene name synonym)|uniprotkb:GBP-TA antigen(gene name synonym)|uniprotkb:GBP5(gene name)|psi-mi:GBP5(display_short)|uniprotkb:UNQ2427/PRO4987(orf name) psi-mi:gbp5_human(display_long)|uniprotkb:Guanine nucleotide-binding protein 5(gene name synonym)|uniprotkb:GTP-binding protein 5(gene name synonym)|uniprotkb:GBP-TA antigen(gene name synonym)|uniprotkb:GBP5(gene name)|psi-mi:GBP5(display_short)|uniprotkb:UNQ2427/PRO4987(orf name) psi-mi:"MI:0071"(molecular sieving) Wehner et al. (2010) pubmed:20180847|imex:IM-15651|mint:MINT-7555023|doi:10.1111/j.1742-4658.2010.07586 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7823847|mint:MINT-7555053|imex:IM-15651-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001127958.1|refseq:NP_443174.1|ensembl:ENSG00000154451(gene)|ensembl:ENST00000370459(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|mint:Q96PP8|rcsb pdb:7CKF|rcsb pdb:7E59|rcsb pdb:7E5A|reactome:R-HSA-877300|interpro:IPR015894(Guanylate-binding protein, N-terminal)|mint:MINT-7555055(identity) refseq:NP_001127958.1|refseq:NP_443174.1|ensembl:ENSG00000154451(gene)|ensembl:ENST00000370459(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|interpro:IPR037684|mint:Q96PP8|rcsb pdb:7CKF|rcsb pdb:7E59|rcsb pdb:7E5A|reactome:R-HSA-877300|interpro:IPR015894(Guanylate-binding protein, N-terminal)|mint:MINT-7555055(identity) - comment:"Stoichiometry: 4.0" comment:"Stoichiometry: 4.0" figure legend:f5b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/19 2014/10/16 rogid:oeKbs0b2DOTZqVLfDuJKrH6tua89606 rogid:oeKbs0b2DOTZqVLfDuJKrH6tua89606 intact-crc:91EB4517C2AB0C2D|rigid:fU8rQq8UmxG5Zi49ZbvvxnBWZzE false - - 4 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)