#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60929	uniprotkb:P70257-2	intact:EBI-2639094|uniprotkb:Q3V155|uniprotkb:Q4VA09|uniprotkb:Q6P8Q3|ensembl:ENSMUSP00000117496|ensembl:ENSMUSP00000138566	intact:EBI-2639084|ensembl:ENSMUSP00000076005	psi-mi:mef2a_mouse(display_long)|uniprotkb:Mef2a(gene name)|psi-mi:Mef2a(display_short)	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639088|imex:IM-13773-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278120.1|refseq:NP_001278121.1|refseq:NP_001278124.1|refseq:NP_001278125.1|refseq:XP_011249116.1|refseq:XP_017177500.1|refseq:NP_001028885.1|refseq:XP_006540749.1|ensembl:ENSMUSG00000030557(gene)|ensembl:ENSMUST00000135493(transcript)|ensembl:ENSMUST00000156690(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q60929	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	psi-mi:"MI:0469"(intact)	-	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	figure legend:Fig 2B.|comment:Nfi is able to specifically bind Mef2A but not Mef2C.  Further coimmunoprecipitations clearly revealed that Nfix2 is the only member of the Nfi family able to bind Mef2A.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/04/09	2014/10/16	rogid:Z/iMKtSs4pNMyjZ2o808rHfEuGk10090	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	intact-crc:98E086F9CF297249|rigid:mYmx3fFXefh2gjnsH9PnT8fn284	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70257-2	uniprotkb:Q02111	intact:EBI-2639084|ensembl:ENSMUSP00000076005	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639150|imex:IM-13773-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	psi-mi:"MI:0469"(intact)	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	-	figure legend:Fig 2E.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/04/09	2014/10/16	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	intact-crc:E544D967E0DE1196|rigid:i78pIoM2vw164zB+0rY/Tdw6lUw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70257-2	uniprotkb:Q60929	intact:EBI-2639084|ensembl:ENSMUSP00000076005	intact:EBI-2639094|uniprotkb:Q3V155|uniprotkb:Q4VA09|uniprotkb:Q6P8Q3|ensembl:ENSMUSP00000117496|ensembl:ENSMUSP00000138566	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:mef2a_mouse(display_long)|uniprotkb:Mef2a(gene name)|psi-mi:Mef2a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639150|imex:IM-13773-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	refseq:NP_001278120.1|refseq:NP_001278121.1|refseq:NP_001278124.1|refseq:NP_001278125.1|refseq:XP_011249116.1|refseq:XP_017177500.1|refseq:NP_001028885.1|refseq:XP_006540749.1|ensembl:ENSMUSG00000030557(gene)|ensembl:ENSMUST00000135493(transcript)|ensembl:ENSMUST00000156690(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q60929	psi-mi:"MI:0469"(intact)	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	-	figure legend:Fig 2E.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/04/09	2014/10/16	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	rogid:Z/iMKtSs4pNMyjZ2o808rHfEuGk10090	intact-crc:E544D967E0DE1196|rigid:i78pIoM2vw164zB+0rY/Tdw6lUw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02078	uniprotkb:P70257-2	intact:EBI-2656305|uniprotkb:Q59GX4|uniprotkb:O43814|uniprotkb:Q14223|uniprotkb:Q14224|uniprotkb:Q96D14|intact:EBI-11323186|uniprotkb:B4DFQ7|uniprotkb:F6XG23|uniprotkb:Q7Z6C9	intact:EBI-2639084|ensembl:ENSMUSP00000076005	psi-mi:mef2a_human(display_long)|uniprotkb:MEF2A(gene name)|psi-mi:MEF2A(display_short)|uniprotkb:MEF2(gene name synonym)|uniprotkb:Serum response factor-like protein 1(gene name synonym)	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639139|imex:IM-13773-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519883.1|refseq:XP_011519884.1|refseq:XP_011519888.1|refseq:NP_001124399.1|refseq:NP_005578.2|refseq:XP_016877679.1|refseq:XP_016877680.1|refseq:XP_016877682.1|refseq:XP_016877683.1|refseq:NP_001124400.1|refseq:NP_001165365.1|refseq:NP_001306135.1|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:1C7U|rcsb pdb:1EGW|rcsb pdb:1LEW|rcsb pdb:3KOV|rcsb pdb:3MU6|rcsb pdb:3P57|rcsb pdb:6BYY|rcsb pdb:6BZ1|reactome:R-HSA-198753|reactome:R-HSA-525793|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|dip:DIP-40711N|mint:Q02078	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	psi-mi:"MI:0469"(intact)	-	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	figure legend:Fig 2D.|comment:"This further confirms  that Nfix2 is the only member of the Nfi family able to bind Mef2A was obtained by BIFC using Nfix2 and Mef2A  fused to the amino(N)- or carboxy(C)-terminal of the yellow fluorescent protein (YFP), respectively, and transfected into C2C12 myoblasts."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/04/09	2019/08/07	rogid:x3duUV06wVmW/uTazIAOWm0cQ8k9606	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	intact-crc:63023196650214D2|rigid:N3uIuAlht1Z8I7jI6Ieg0kSRYlE	false	yellow fluorescent protein tag:?-?	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q02078	uniprotkb:Q04759	intact:EBI-2656305|uniprotkb:Q59GX4|uniprotkb:O43814|uniprotkb:Q14223|uniprotkb:Q14224|uniprotkb:Q96D14|intact:EBI-11323186|uniprotkb:B4DFQ7|uniprotkb:F6XG23|uniprotkb:Q7Z6C9	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	psi-mi:mef2a_human(display_long)|uniprotkb:MEF2A(gene name)|psi-mi:MEF2A(display_short)|uniprotkb:MEF2(gene name synonym)|uniprotkb:Serum response factor-like protein 1(gene name synonym)	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639198|imex:IM-13773-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519883.1|refseq:XP_011519884.1|refseq:XP_011519888.1|refseq:NP_001124399.1|refseq:NP_005578.2|refseq:XP_016877679.1|refseq:XP_016877680.1|refseq:XP_016877682.1|refseq:XP_016877683.1|refseq:NP_001124400.1|refseq:NP_001165365.1|refseq:NP_001306135.1|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:1C7U|rcsb pdb:1EGW|rcsb pdb:1LEW|rcsb pdb:3KOV|rcsb pdb:3MU6|rcsb pdb:3P57|rcsb pdb:6BYY|rcsb pdb:6BZ1|reactome:R-HSA-198753|reactome:R-HSA-525793|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|dip:DIP-40711N|mint:Q02078	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 2F.|comment:Mef2A and PKCtheta were not able to bind directly to each other, while binding was rescued in the presence of Nfix2, suggesting that Nfix acts as a bridge between Mef2A and PKCtheta.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jeg3)|taxid:9606(Homo sapiens choriocarcinoma JEG3)	-	2010/04/09	2014/10/16	rogid:x3duUV06wVmW/uTazIAOWm0cQ8k9606	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	intact-crc:A72CDAC07B3E083F|rigid:g/kk6STP71qejTopo36KDIeIqck	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02078	uniprotkb:P70257-2	intact:EBI-2656305|uniprotkb:Q59GX4|uniprotkb:O43814|uniprotkb:Q14223|uniprotkb:Q14224|uniprotkb:Q96D14|intact:EBI-11323186|uniprotkb:B4DFQ7|uniprotkb:F6XG23|uniprotkb:Q7Z6C9	intact:EBI-2639084|ensembl:ENSMUSP00000076005	psi-mi:mef2a_human(display_long)|uniprotkb:MEF2A(gene name)|psi-mi:MEF2A(display_short)|uniprotkb:MEF2(gene name synonym)|uniprotkb:Serum response factor-like protein 1(gene name synonym)	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639198|imex:IM-13773-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519883.1|refseq:XP_011519884.1|refseq:XP_011519888.1|refseq:NP_001124399.1|refseq:NP_005578.2|refseq:XP_016877679.1|refseq:XP_016877680.1|refseq:XP_016877682.1|refseq:XP_016877683.1|refseq:NP_001124400.1|refseq:NP_001165365.1|refseq:NP_001306135.1|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:1C7U|rcsb pdb:1EGW|rcsb pdb:1LEW|rcsb pdb:3KOV|rcsb pdb:3MU6|rcsb pdb:3P57|rcsb pdb:6BYY|rcsb pdb:6BZ1|reactome:R-HSA-198753|reactome:R-HSA-525793|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|dip:DIP-40711N|mint:Q02078	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	psi-mi:"MI:0469"(intact)	-	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	figure legend:Fig 2F.|comment:Mef2A and PKCtheta were not able to bind directly to each other, while binding was rescued in the presence of Nfix2, suggesting that Nfix acts as a bridge between Mef2A and PKCtheta.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jeg3)|taxid:9606(Homo sapiens choriocarcinoma JEG3)	-	2010/04/09	2014/10/16	rogid:x3duUV06wVmW/uTazIAOWm0cQ8k9606	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	intact-crc:A72CDAC07B3E083F|rigid:g/kk6STP71qejTopo36KDIeIqck	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60929	ensembl:ENSMUSG00000030399	intact:EBI-2639094|uniprotkb:Q3V155|uniprotkb:Q4VA09|uniprotkb:Q6P8Q3|ensembl:ENSMUSP00000117496|ensembl:ENSMUSP00000138566	intact:EBI-2639862	psi-mi:mef2a_mouse(display_long)|uniprotkb:Mef2a(gene name)|psi-mi:Mef2a(display_short)	psi-mi:kcrm_mouse_gene(display_short)|psi-mi:ENSMUSG00000030399(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639802|imex:IM-13773-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001278120.1|refseq:NP_001278121.1|refseq:NP_001278124.1|refseq:NP_001278125.1|refseq:XP_011249116.1|refseq:XP_017177500.1|refseq:NP_001028885.1|refseq:XP_006540749.1|ensembl:ENSMUSG00000030557(gene)|ensembl:ENSMUST00000135493(transcript)|ensembl:ENSMUST00000156690(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q60929	-	-	-	comment:Creatine kinase M-type	figure legend:Fig S2C.|comment:"ChIP assay performed on HA-Nfix2-expressing fetal myotubes (E16.5 HA-Nfix2) confirmed the direct binding of Nfix on MCK and beta-enolase enhancer/promoter. Binding to the MCK enhancer/promoter regions was found at: -1200/-1048 and -2500/-2400."|caution:"Fig S2C image legend  states: Unpurified fetal myoblasts (E16.5) were (used)... However, Text states: \" HA-Nfix2-expressing fetal myotubes (E16.5 HA-Nfix2) confirmed.... (Figure S2C)\" (were used)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fetal-myotubes)|taxid:10090(Mus musculus fetal myotubes)	-	2010/04/09	2014/10/16	rogid:Z/iMKtSs4pNMyjZ2o808rHfEuGk10090	-	intact-crc:1855F8420C9EAEF0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70257-2	ensembl:ENSMUSG00000060600	intact:EBI-2639084|ensembl:ENSMUSP00000076005	intact:EBI-2639916	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:enob_mouse_gene(display_short)|psi-mi:ENSMUSG00000060600(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639898|imex:IM-13773-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	-	-	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	-	figure legend:Fig S2C.|comment:"ChIP assay performed on HA-Nfix2-expressing fetal myotubes (E16.5 HA-Nfix2) confirmed the direct binding of Nfix on MCK and beta-enolase enhancer/promoter.  Binding to the Beta-enolase  enhancer/promoter regions was found at: region +504/+637."|caution:"Fig S2C image legend states: Unpurified fetal myoblasts (E16.5) were (used)... However, Text states: \" HA-Nfix2-expressing fetal myotubes (E16.5 HA-Nfix2) confirmed.... (Figure S2C) (were used)\"."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fetal-myotubes)|taxid:10090(Mus musculus fetal myotubes)	-	2010/04/09	2014/10/16	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	-	intact-crc:81BE302D184B937B	false	ha tag:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
ensembl:ENSMUSG00000030399	uniprotkb:P70257-2	intact:EBI-2639862	intact:EBI-2639084|ensembl:ENSMUSP00000076005	psi-mi:kcrm_mouse_gene(display_short)|psi-mi:ENSMUSG00000030399(display_long)	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2657481|imex:IM-13773-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	-	comment:Creatine kinase M-type	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	figure legend:Fig S2C.|comment:"ChIP assay performed on HA-Nfix2-expressing fetal myotubes (E16.5 HA-Nfix2) confirmed the direct binding of Nfix on MCK and beta-enolase enhancer/promoter. Binding to the MCK enhancer/promoter regions was found at: -1200/-1048 and -2500/-2400."|caution:"Fig S2C image legend  states: Unpurified fetal myoblasts (E16.5) were (used)... However, Text states: \" HA-Nfix2-expressing fetal myotubes (E16.5 HA-Nfix2) confirmed.... (Figure S2C) (were used)\"."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fetal-myotubes)|taxid:10090(Mus musculus fetal myotubes)	-	2010/04/09	2014/10/16	-	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	intact-crc:9E06185E6A7CE5DB	false	-	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60929	ensembl:ENSMUSG00000060600	intact:EBI-2639094|uniprotkb:Q3V155|uniprotkb:Q4VA09|uniprotkb:Q6P8Q3|ensembl:ENSMUSP00000117496|ensembl:ENSMUSP00000138566	intact:EBI-2639916	psi-mi:mef2a_mouse(display_long)|uniprotkb:Mef2a(gene name)|psi-mi:Mef2a(display_short)	psi-mi:enob_mouse_gene(display_short)|psi-mi:ENSMUSG00000060600(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2657490|imex:IM-13773-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001278120.1|refseq:NP_001278121.1|refseq:NP_001278124.1|refseq:NP_001278125.1|refseq:XP_011249116.1|refseq:XP_017177500.1|refseq:NP_001028885.1|refseq:XP_006540749.1|ensembl:ENSMUSG00000030557(gene)|ensembl:ENSMUST00000135493(transcript)|ensembl:ENSMUST00000156690(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q60929	-	-	-	-	figure legend:Fig S2C.|comment:"ChIP assay performed on HA-Nfix2-expressing fetal myotubes (E16.5 HA-Nfix2) confirmed the direct binding of Nfix on MCK and beta-enolase enhancer/promoter.  Binding to the Beta-enolase  enhancer/promoter regions was found at: region +504/+637."|caution:"Fig S2C image legend states: Unpurified fetal myoblasts (E16.5) were (used)... However, Text states: \" HA-Nfix2-expressing fetal myotubes (E16.5 HA-Nfix2) confirmed.... (Figure S2C) (were used)\"."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fetal-myotubes)|taxid:10090(Mus musculus fetal myotubes)	-	2010/04/09	2014/10/16	rogid:Z/iMKtSs4pNMyjZ2o808rHfEuGk10090	-	intact-crc:6CB63064A461F15E	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02111	uniprotkb:Q02078	intact:EBI-2639157|ensembl:ENSMUSP00000028118	intact:EBI-2656305|uniprotkb:Q59GX4|uniprotkb:O43814|uniprotkb:Q14223|uniprotkb:Q14224|uniprotkb:Q96D14|intact:EBI-11323186|uniprotkb:B4DFQ7|uniprotkb:F6XG23|uniprotkb:Q7Z6C9	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:mef2a_human(display_long)|uniprotkb:MEF2A(gene name)|psi-mi:MEF2A(display_short)|uniprotkb:MEF2(gene name synonym)|uniprotkb:Serum response factor-like protein 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639224|imex:IM-13773-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	refseq:XP_011519883.1|refseq:XP_011519884.1|refseq:XP_011519888.1|refseq:NP_001124399.1|refseq:NP_005578.2|refseq:XP_016877679.1|refseq:XP_016877680.1|refseq:XP_016877682.1|refseq:XP_016877683.1|refseq:NP_001124400.1|refseq:NP_001165365.1|refseq:NP_001306135.1|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:1C7U|rcsb pdb:1EGW|rcsb pdb:1LEW|rcsb pdb:3KOV|rcsb pdb:3MU6|rcsb pdb:3P57|rcsb pdb:6BYY|rcsb pdb:6BZ1|reactome:R-HSA-198753|reactome:R-HSA-525793|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|dip:DIP-40711N|mint:Q02078	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig 2G.|comment:Myoblast PKCtheta was able to weakly phosphorylate Mef2A, but this ability was strongly enhanced in the presence of Nfix2.|resulting-ptm:phosphorylation of Mef2a.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/04/09	2014/10/16	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	rogid:x3duUV06wVmW/uTazIAOWm0cQ8k9606	intact-crc:B9F7E9BFAB325FC2|rigid:1k1M7HXMt7wa1//NhoFb3TC1sHs	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q02111	uniprotkb:P70257-2	intact:EBI-2639157|ensembl:ENSMUSP00000028118	intact:EBI-2639084|ensembl:ENSMUSP00000076005	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639224|imex:IM-13773-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	figure legend:Fig 2G.|comment:Myoblast PKCtheta was able to weakly phosphorylate Mef2A, but this ability was strongly enhanced in the presence of Nfix2.|resulting-ptm:phosphorylation of Mef2a.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/04/09	2014/10/16	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	intact-crc:B9F7E9BFAB325FC2|rigid:1k1M7HXMt7wa1//NhoFb3TC1sHs	false	-	ha tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P70257-2	uniprotkb:Q02111	intact:EBI-2639084|ensembl:ENSMUSP00000076005	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2639240|imex:IM-13773-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	psi-mi:"MI:0469"(intact)	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	-	figure legend:Fig 2G LHS.|comment:"PKCtheta was immunoprecipitated in C2C12 myoblasts transfected with HA-Nfix2 plasmid. The amount of PKCθ and Nfix (by anti-HA antibody) in the immunoprecipitates was assessed by western blot."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/04/09	2014/10/16	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	intact-crc:CB686F04701209B5|rigid:9qLIwQZlFCje73AdJvQX0cdyfvc	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
ensembl:ENSMUSG00000001911	uniprotkb:P47239	intact:EBI-2656470	intact:EBI-2656438|uniprotkb:Q9ES16|ensembl:ENSMUSP00000030508	psi-mi:nfix_mouse_gene(display_short)|psi-mi:ENSMUSG00000001911(display_long)	psi-mi:pax7_mouse(display_long)|uniprotkb:Pax7(gene name)|psi-mi:Pax7(display_short)|uniprotkb:Pax-7(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2657467|imex:IM-13773-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_035169.1|ensembl:ENSMUSG00000028736(gene)|ensembl:ENSMUST00000030508(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010453"(regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014813"(skeletal muscle satellite cell commitment)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060415"(muscle tissue morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000288"(positive regulation of myoblast proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022106|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565	-	-	-	figure legend:Fig 7C.|comment:"Pax7 directly binds, with different affinity, to four putative Pax7 binding sites on the Nfix promoter, regions:  -1677/-1659, -2290/-2272, -3898/-3880, and  -4274/-4256."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fetal-myoblasts)|taxid:10090(Mus musculus fetal myoblasts)	-	2010/04/09	2014/10/16	-	rogid:a2SY+UdfwWY2L6r85HKuwBB9oMY10090	intact-crc:D81826485B2F8849	false	-	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
ensembl:ENSMUSG00000023411	uniprotkb:P70257-2	intact:EBI-2656429	intact:EBI-2639084|ensembl:ENSMUSP00000076005	psi-mi:nfac4_mouse_gene(display_short)|psi-mi:ENSMUSG00000023411(display_long)	psi-mi:p70257-2(display_long)|uniprotkb:Nfix(gene name)|psi-mi:Nfix(display_short)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:Nuclear factor I/X(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Messina et al. (2010)	imex:IM-13773|pubmed:20178747	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2657474|imex:IM-13773-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	intact:EBI-2639047(isoform-parent)|ensembl:ENSMUSG00000001911(gene)|ensembl:ENSMUST00000076715(transcript)	-	-	isoform-comment:Contains a phosphoserine at position 301. Contains a phosphoserine at position 320.	figure legend:Fig 6C.|comment:"A ChIP assay for Nfix2 failed to detect direct binding on the slow MyHC promoter, however direct binding of Nfix2 on the promoter of NFATc4 was demonstrated at (-3770/-3750)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fetal-myoblasts)|taxid:10090(Mus musculus fetal myoblasts)	-	2010/04/09	2014/10/16	-	rogid:cGJ8lAsVX1dYxjciiR2T3g/r9ok10090	intact-crc:EF1206EEE8F0A94E	false	-	ha tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)