#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6PDX6	uniprotkb:P61077	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2795876|imex:IM-19223-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	go:"GO:0016567"(protein ubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	sample process:UBA1 purified;|resulting-ptm:Ubiquitination of Rnf220|figure legend:Fig. 1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/17	2014/10/16	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	intact-crc:5EE2300ED6A99369|rigid:EyWKSyyO7pPFvenkmnPkjW/iBas	false	binding-associated region:514-552(IPR001841)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PDX6	uniprotkb:Q29504	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	intact:EBI-975625	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:uba1_rabit(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2795876|imex:IM-19223-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR042302|refseq:NP_001075840.1|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018965|interpro:IPR019572|interpro:IPR018075|interpro:IPR018074|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR038252|interpro:IPR033127|interpro:IPR032418|interpro:IPR032420|interpro:IPR042449|interpro:IPR035985|interpro:IPR042063	go:"GO:0016567"(protein ubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	sample process:UBA1 purified;|resulting-ptm:Ubiquitination of Rnf220|figure legend:Fig. 1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/17	2014/10/16	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	rogid:kBSF1JlX6FGGw2Fs4klp7fFz5cQ9986	intact-crc:5EE2300ED6A99369|rigid:EyWKSyyO7pPFvenkmnPkjW/iBas	false	binding-associated region:514-552(IPR001841)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PDX6	uniprotkb:P0CG47	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2795876|imex:IM-19223-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	go:"GO:0016567"(protein ubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	sample process:UBA1 purified;|resulting-ptm:Ubiquitination of Rnf220|figure legend:Fig. 1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/17	2014/10/16	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:5EE2300ED6A99369|rigid:EyWKSyyO7pPFvenkmnPkjW/iBas	false	binding-associated region:514-552(IPR001841)	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52482	uniprotkb:Q6PDX6	intact:EBI-2795907|ensembl:ENSMUSP00000022296	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	psi-mi:ub2e1_mouse(display_long)|uniprotkb:Ube2e1(gene name)|psi-mi:Ube2e1(display_short)|uniprotkb:Ubce5(gene name synonym)|uniprotkb:Ubcm3(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E1(gene name synonym)|uniprotkb:Ubiquitin carrier protein E1(gene name synonym)|uniprotkb:UbcM3(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme E1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E1(gene name synonym)	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2795903|imex:IM-19223-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033481.1|ensembl:ENSMUSG00000021774(gene)|ensembl:ENSMUST00000022296(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-MMU-1169408|reactome:R-MMU-141430|reactome:R-MMU-174048|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174184|reactome:R-MMU-176407|reactome:R-MMU-176408|reactome:R-MMU-176409|reactome:R-MMU-176412|reactome:R-MMU-179409|reactome:R-MMU-2467813|reactome:R-MMU-2559582|reactome:R-MMU-69017|reactome:R-MMU-8866652|reactome:R-MMU-8866654|reactome:R-MMU-983168|reactome:R-MMU-174178	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	-	-	-	figure legend:Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/17	2014/10/16	rogid:ttQG3UjHSEMPsnt94FrXv44JtnA10090	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	intact-crc:534E5B54A61D22D7|rigid:msFX4raPRIM8QXOtRwxTXd8baCw	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P52483	uniprotkb:Q6PDX6	intact:EBI-2795929|uniprotkb:O09180|uniprotkb:Q3TI00|uniprotkb:Q91X63|ensembl:ENSMUSP00000028398|ensembl:ENSMUSP00000113463	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	psi-mi:ub2e3_mouse(display_long)|uniprotkb:Ube2e3(gene name)|psi-mi:Ube2e3(display_short)|uniprotkb:Ubce4(gene name synonym)|uniprotkb:Ubcm2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3(gene name synonym)|uniprotkb:Ubiquitin carrier protein E3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-23 kDa(gene name synonym)|uniprotkb:UbcM2(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E3(gene name synonym)	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2795955|imex:IM-19223-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033480.1|refseq:XP_006499224.1|refseq:XP_006499225.1|refseq:XP_006499226.1|ensembl:ENSMUSG00000027011(gene)|ensembl:ENSMUST00000028398(transcript)|ensembl:ENSMUST00000121433(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0040008"(regulation of growth)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-MMU-983168|go:"GO:0005524"(ATP binding)	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	-	-	-	figure legend:Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/17	2014/10/16	rogid:1Z6f7pg9hkbmoQwMjdGtkhWP/9A10090	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	intact-crc:08602B01B7D643E9|rigid:kUMMFoIGU9IcITK81As2tJWPnb0	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6PDX6	uniprotkb:Q62141	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2795964|imex:IM-19223-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	figure legend:Fig. 2A, 2D|caution:Exact coordinates of PAH domains not given in publication so have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/17	2014/10/16	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	intact-crc:FFC8D04C54F7EEB9|rigid:xbFeOF1HhuL7pxWlMfJRG2mPetk	false	myc tag:?-?	flag tag:?-?|sufficient binding region:1-100..100(IPR003822)|sufficient binding region:145..145-230..230(IPR003822)|sufficient binding region:283..283-360..360(IPR003822)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6PDX6	uniprotkb:Q62141	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2795973|imex:IM-19223-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	figure legend:Figs. 2A, 2C|comment:A number of different domains of Rnf220 were seen as interacting with Sin3B.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/17	2014/10/16	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	intact-crc:D4F3443B091D8291|rigid:xbFeOF1HhuL7pxWlMfJRG2mPetk	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6PDX6	uniprotkb:Q62141	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2796000|imex:IM-19223-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/17	2014/10/16	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	intact-crc:4305F1AB3BC609B4|rigid:xbFeOF1HhuL7pxWlMfJRG2mPetk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6PDX6	uniprotkb:Q62141	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2796011|imex:IM-19223-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	-	-	-	figure legend:Figs. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/17	2014/10/16	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	intact-crc:1DD817F303466B03|rigid:xbFeOF1HhuL7pxWlMfJRG2mPetk	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62141	uniprotkb:Q6PDX6	intact:EBI-591450|uniprotkb:O54976|uniprotkb:Q6A013|uniprotkb:Q8VCB8|uniprotkb:Q8VDZ5|ensembl:ENSMUSP00000004494	intact:EBI-2795840|uniprotkb:A2APP0|uniprotkb:Q3T9M4|uniprotkb:Q3V3D7|uniprotkb:Q8JZY5|ensembl:ENSMUSP00000030439	psi-mi:sin3b_mouse(display_long)|uniprotkb:Transcriptional corepressor Sin3b(gene name synonym)|uniprotkb:Histone deacetylase complex subunit Sin3b(gene name synonym)|uniprotkb:Sin3b(gene name)|psi-mi:Sin3b(display_short)|uniprotkb:Kiaa0700(gene name synonym)	psi-mi:rn220_mouse(display_long)|uniprotkb:Rnf220(gene name)|psi-mi:Rnf220(display_short)|uniprotkb:RING finger protein 220(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Rnf220(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Kong et al. (2010)	pubmed:20170641|imex:IM-19223	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2796027|imex:IM-19223-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106719.1|refseq:NP_033214.2|dip:DIP-470N|ensembl:ENSMUSG00000031622(gene)|ensembl:ENSMUST00000004494(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0001741"(XY body)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0016580"(Sin3 complex)|go:"GO:0030849"(autosome)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048738"(cardiac muscle tissue development)|interpro:IPR003822(Paired amphipathic helix)|interpro:IPR013194(Histone deacetylase interacting)|interpro:IPR031693|interpro:IPR036600|interpro:IPR039774|mint:Q62141|rcsb pdb:1E91|rcsb pdb:1PD7|rcsb pdb:2CR7|rcsb pdb:2CZY|rcsb pdb:2F05|rcsb pdb:5Y95|reactome:R-MMU-400206|reactome:R-MMU-8936459|reactome:R-MMU-9707564|go:"GO:0016575"(histone deacetylation)	refseq:XP_011238891.1|refseq:NP_001297658.1|refseq:NP_001297659.1|refseq:NP_001297660.1|refseq:NP_080015.3|refseq:XP_017175844.1|refseq:XP_017175846.1|ensembl:ENSMUSG00000028677(gene)|ensembl:ENSMUST00000030439(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031824|reactome:R-MMU-983168|interpro:IPR040178	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figs. 5B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2010/06/17	2014/10/16	rogid:RILCV7LIlLhVsSBz43m63WcJ0B810090	rogid:RRtB1Q32271+qgX/wbTYHw6BJOA10090	intact-crc:5BFD2F4E72DF48F7|rigid:xbFeOF1HhuL7pxWlMfJRG2mPetk	false	myc tag:?-?	flag tag:?-?|necessary binding region:514-552(IPR001841)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)