#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P17947 uniprotkb:Q15156 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-867256 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609887|imex:IM-13602-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 intact-crc:1E0CFDD138593161 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 ensembl:ENSG00000077420 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-2609891 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:ab1ip_human_gene(display_short)|psi-mi:ENSG00000077420(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609887|imex:IM-13602-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 - intact-crc:1E0CFDD138593161 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609897|imex:IM-13602-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:3D4026A992FB5D9C false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000077420 intact:EBI-867256 intact:EBI-2609891 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:ab1ip_human_gene(display_short)|psi-mi:ENSG00000077420(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609897|imex:IM-13602-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:3D4026A992FB5D9C false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000119535 intact:EBI-867256 intact:EBI-2609906 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:csf3r_human_gene(display_short)|psi-mi:ENSG00000119535(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609902|imex:IM-13602-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:8EF652FDDB6529EF false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609902|imex:IM-13602-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:8EF652FDDB6529EF false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 uniprotkb:Q15156 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-867256 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609909|imex:IM-13602-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 intact-crc:B66DCEE2BA14B99A false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 ensembl:ENSG00000119535 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-2609906 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:csf3r_human_gene(display_short)|psi-mi:ENSG00000119535(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609909|imex:IM-13602-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 - intact-crc:B66DCEE2BA14B99A false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 uniprotkb:Q15156 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-867256 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609914|imex:IM-13602-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 intact-crc:7D0990C43E90B2D6 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 ensembl:ENSG00000182511 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-2609919 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:fes_human_gene(display_short)|psi-mi:ENSG00000182511(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609914|imex:IM-13602-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 - intact-crc:7D0990C43E90B2D6 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609922|imex:IM-13602-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:45920CDB5FE122A3 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000182511 intact:EBI-867256 intact:EBI-2609919 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:fes_human_gene(display_short)|psi-mi:ENSG00000182511(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609922|imex:IM-13602-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:45920CDB5FE122A3 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000087086 intact:EBI-867256 intact:EBI-2609932 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:fril_human_gene(display_short)|psi-mi:ENSG00000087086(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609927|imex:IM-13602-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:4140C70BA900BC28 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609927|imex:IM-13602-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:4140C70BA900BC28 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 uniprotkb:Q15156 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-867256 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609935|imex:IM-13602-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 intact-crc:79DB5B14C8712C5D false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 ensembl:ENSG00000087086 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-2609932 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:fril_human_gene(display_short)|psi-mi:ENSG00000087086(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609935|imex:IM-13602-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 - intact-crc:79DB5B14C8712C5D false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 uniprotkb:Q15156 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-867256 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609940|imex:IM-13602-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 intact-crc:F885EB029C99ADB9 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 ensembl:ENSG00000205220 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-2609944 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:psb10_human_gene(display_short)|psi-mi:ENSG00000205220(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609940|imex:IM-13602-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 - intact-crc:F885EB029C99ADB9 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609946|imex:IM-13602-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:C01E771DFDE83DCC false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000205220 intact:EBI-867256 intact:EBI-2609944 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:psb10_human_gene(display_short)|psi-mi:ENSG00000205220(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609946|imex:IM-13602-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:C01E771DFDE83DCC false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000186891 intact:EBI-867256 intact:EBI-2609956 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:tnr18_human_gene(display_short)|psi-mi:ENSG00000186891(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609951|imex:IM-13602-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:567FCF3F1447C77F false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609951|imex:IM-13602-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:567FCF3F1447C77F false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 uniprotkb:Q15156 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-867256 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609958|imex:IM-13602-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 intact-crc:6EE453207536570A false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 ensembl:ENSG00000186891 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-2609956 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:tnr18_human_gene(display_short)|psi-mi:ENSG00000186891(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609958|imex:IM-13602-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 - intact-crc:6EE453207536570A false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 uniprotkb:Q15156 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-867256 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609963|imex:IM-13602-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 intact-crc:4A7A979AD5F3A77B false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17947 ensembl:ENSG00000101336 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 intact:EBI-2609967 psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:hck_human_gene(display_short)|psi-mi:ENSG00000101336(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609963|imex:IM-13602-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 - intact-crc:4A7A979AD5F3A77B false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000101336 intact:EBI-867256 intact:EBI-2609967 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:hck_human_gene(display_short)|psi-mi:ENSG00000101336(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609970|imex:IM-13602-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:72E10B85B482370E false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609970|imex:IM-13602-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) - - - comment:Validation of the co-presence of PML/RARa and PU.1 on the same PU.1-RAREh regions. Regions immunoprecipitated with the first antibody were re-immunoprecipitated with the second antibody indicating the binding of PU.1 and PML/RARa to the same DNA.|figure legend:Fig 3B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:72E10B85B482370E false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:O00470 uniprotkb:Q53ET0 intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369 intact:EBI-1181987|uniprotkb:Q7Z3X7|uniprotkb:Q6UUV8|uniprotkb:Q8N332|ensembl:ENSP00000357622 psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short) psi-mi:crtc2_human(display_long)|uniprotkb:TORC2(gene name synonym)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)|uniprotkb:CRTC2(gene name)|psi-mi:CRTC2(display_short) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2889303|imex:IM-13602-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472 refseq:NP_859066.1|ensembl:ENSP00000357622|ensembl:ENSG00000160741(gene)|ensembl:ENST00000368633(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|mint:Q53ET0|rcsb pdb:4HTM|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-29950N psi-mi:"MI:0469"(intact) - - figure legend:Fig 5H.|comment:The MEIS1/CREB association depends on TORC.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2020/10/21 rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606 rogid:p/QkUoueS1+KCLb0il8SMt8JwQM9606 intact-crc:CDE28799E08A77EB|rigid:JpWbwZHfHwnSBRGGzuh8O/Jvtys false ha tag:?-? - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:O00470 uniprotkb:P16220 intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369 intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963 psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short) psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2889303|imex:IM-13602-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472 go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616 psi-mi:"MI:0469"(intact) - - figure legend:Fig 5H.|comment:The MEIS1/CREB association depends on TORC.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2020/10/21 rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606 rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606 intact-crc:CDE28799E08A77EB|rigid:JpWbwZHfHwnSBRGGzuh8O/Jvtys false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2609998|imex:IM-13602-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) psi-mi:"MI:0469"(intact) - - comment:PML/RARa was specifically detected in immunoprecipitates obtained with the anti-PU.1 antibody, suggesting that an interaction between PML/RARa and PU.1 occurred in vivo.|figure legend:Fig 3D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:4401D533F0913E9B|rigid:7Umr4JxZGIy/qCtgljT+6IKMZgY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610005|imex:IM-13602-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) psi-mi:"MI:0469"(intact) - - comment:PML/RARa was specifically detected in immunoprecipitates obtained with the anti-PU.1 antibody, suggesting that an interaction between PML/RARa and PU.1 occurred in vivo.|figure legend:Fig 3D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:59BF740550490EE0|rigid:7Umr4JxZGIy/qCtgljT+6IKMZgY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15156 ensembl:ENSG00000101336 intact:EBI-867256 intact:EBI-2609967 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:hck_human_gene(display_short)|psi-mi:ENSG00000101336(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610045|imex:IM-13602-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:RXR was present in some, but not all, of the tested ChIP regions.|figure legend:Fig 5F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:3EC59D4CD3442023 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000087086 intact:EBI-867256 intact:EBI-2609932 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:fril_human_gene(display_short)|psi-mi:ENSG00000087086(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610051|imex:IM-13602-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:RXR was present in some, but not all, of the tested ChIP regions.|figure legend:Fig 5F.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:22BC33DF6EC17030 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000077092 intact:EBI-867256 intact:EBI-2610059 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:rarb_human_gene(display_short)|psi-mi:ENSG00000077092(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610061|imex:IM-13602-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:RXR was present in some, but not all, of the tested ChIP regions.|figure legend:Fig 5F.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:39B67F679E633291 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 ensembl:ENSG00000066336 intact:EBI-867256 intact:EBI-2610057 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human_gene(display_short)|psi-mi:ENSG00000066336(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610067|imex:IM-13602-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) - - - - comment:RXR was present in some, but not all, of the tested ChIP regions.|figure legend:Fig 5F.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 - intact-crc:4C2381A483AD6CFC false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P19793 ensembl:ENSG00000101336 intact:EBI-78598|uniprotkb:Q2V504|uniprotkb:B3KY83|uniprotkb:Q2NL52|ensembl:ENSP00000419692 intact:EBI-2609967 psi-mi:rxra_human(display_long)|uniprotkb:RXRA(gene name)|psi-mi:RXRA(display_short)|uniprotkb:NR2B1(gene name synonym)|uniprotkb:Retinoid X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group B member 1(gene name synonym) psi-mi:hck_human_gene(display_short)|psi-mi:ENSG00000101336(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610074|imex:IM-13602-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_002948.1|refseq:NP_001278850.1|dip:DIP-641N|ensembl:ENSG00000186350(gene)|ensembl:ENST00000481739(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000003(Retinoid X receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021780|interpro:IPR035500|mint:P19793|rcsb pdb:1BY4|rcsb pdb:1DSZ|rcsb pdb:1FBY|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1G1U|rcsb pdb:1G5Y|rcsb pdb:1K74|rcsb pdb:1MV9|rcsb pdb:1MVC|rcsb pdb:1MZN|rcsb pdb:1R0N|rcsb pdb:1RDT|rcsb pdb:1RXR|rcsb pdb:1XLS|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YNW|rcsb pdb:2ACL|rcsb pdb:2NLL|rcsb pdb:2P1T|rcsb pdb:2P1U|rcsb pdb:2P1V|rcsb pdb:2ZXZ|rcsb pdb:2ZY0|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3E94|rcsb pdb:3FAL|rcsb pdb:3FC6|rcsb pdb:3FUG|rcsb pdb:3H0A|rcsb pdb:3KWY|rcsb pdb:3NSP|rcsb pdb:3NSQ|rcsb pdb:3OAP|rcsb pdb:3OZJ|rcsb pdb:3PCU|rcsb pdb:3R2A|rcsb pdb:3R5M|rcsb pdb:3UVV|rcsb pdb:4CN2|rcsb pdb:4CN3|rcsb pdb:4CN5|rcsb pdb:4CN7|rcsb pdb:4J5W|rcsb pdb:4J5X|rcsb pdb:4K4J|rcsb pdb:4K6I|rcsb pdb:4M8E|rcsb pdb:4M8H|rcsb pdb:4N5G|rcsb pdb:4N8R|rcsb pdb:4NQA|rcsb pdb:4OC7|rcsb pdb:4POH|rcsb pdb:4POJ|rcsb pdb:4PP3|rcsb pdb:4PP5|rcsb pdb:4RFW|rcsb pdb:4RMC|rcsb pdb:4RMD|rcsb pdb:4RME|rcsb pdb:4ZO1|rcsb pdb:4ZSH|rcsb pdb:5EC9|rcsb pdb:5JI0|rcsb pdb:5LYQ|rcsb pdb:5MJ5|rcsb pdb:5MK4|rcsb pdb:5MKJ|rcsb pdb:5MKU|rcsb pdb:5MMW|rcsb pdb:5TBP|rcsb pdb:5UAN|rcsb pdb:5Z12|rcsb pdb:5ZQU|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6FBQ|rcsb pdb:6FBR|rcsb pdb:6HN6|rcsb pdb:6JNO|rcsb pdb:6JNR|rcsb pdb:6L6K|rcsb pdb:6LB4|rcsb pdb:6LB5|rcsb pdb:6LB6|rcsb pdb:6SJM|rcsb pdb:6STI|rcsb pdb:6XWG|rcsb pdb:6XWH|rcsb pdb:7A77|rcsb pdb:7B88|rcsb pdb:7B9O|rcsb pdb:7CFO|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-200425|reactome:R-HSA-204174|reactome:R-HSA-211976|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9616222|reactome:R-HSA-9623433|reactome:R-HSA-9632974|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:3R29 - - - - comment:RXR was present in some, but not all, of the tested ChIP regions.|figure legend:Fig 5F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 rogid:gKnKFur3dYudXOAePzqRZJxqzYQ9606 - intact-crc:F621A07BB69866E7 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) ensembl:ENSG00000087086 uniprotkb:P19793 intact:EBI-2609932 intact:EBI-78598|uniprotkb:Q2V504|uniprotkb:B3KY83|uniprotkb:Q2NL52|ensembl:ENSP00000419692 psi-mi:fril_human_gene(display_short)|psi-mi:ENSG00000087086(display_long) psi-mi:rxra_human(display_long)|uniprotkb:RXRA(gene name)|psi-mi:RXRA(display_short)|uniprotkb:NR2B1(gene name synonym)|uniprotkb:Retinoid X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group B member 1(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610081|imex:IM-13602-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:NP_002948.1|refseq:NP_001278850.1|dip:DIP-641N|ensembl:ENSG00000186350(gene)|ensembl:ENST00000481739(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000003(Retinoid X receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021780|interpro:IPR035500|mint:P19793|rcsb pdb:1BY4|rcsb pdb:1DSZ|rcsb pdb:1FBY|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1G1U|rcsb pdb:1G5Y|rcsb pdb:1K74|rcsb pdb:1MV9|rcsb pdb:1MVC|rcsb pdb:1MZN|rcsb pdb:1R0N|rcsb pdb:1RDT|rcsb pdb:1RXR|rcsb pdb:1XLS|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YNW|rcsb pdb:2ACL|rcsb pdb:2NLL|rcsb pdb:2P1T|rcsb pdb:2P1U|rcsb pdb:2P1V|rcsb pdb:2ZXZ|rcsb pdb:2ZY0|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3E94|rcsb pdb:3FAL|rcsb pdb:3FC6|rcsb pdb:3FUG|rcsb pdb:3H0A|rcsb pdb:3KWY|rcsb pdb:3NSP|rcsb pdb:3NSQ|rcsb pdb:3OAP|rcsb pdb:3OZJ|rcsb pdb:3PCU|rcsb pdb:3R2A|rcsb pdb:3R5M|rcsb pdb:3UVV|rcsb pdb:4CN2|rcsb pdb:4CN3|rcsb pdb:4CN5|rcsb pdb:4CN7|rcsb pdb:4J5W|rcsb pdb:4J5X|rcsb pdb:4K4J|rcsb pdb:4K6I|rcsb pdb:4M8E|rcsb pdb:4M8H|rcsb pdb:4N5G|rcsb pdb:4N8R|rcsb pdb:4NQA|rcsb pdb:4OC7|rcsb pdb:4POH|rcsb pdb:4POJ|rcsb pdb:4PP3|rcsb pdb:4PP5|rcsb pdb:4RFW|rcsb pdb:4RMC|rcsb pdb:4RMD|rcsb pdb:4RME|rcsb pdb:4ZO1|rcsb pdb:4ZSH|rcsb pdb:5EC9|rcsb pdb:5JI0|rcsb pdb:5LYQ|rcsb pdb:5MJ5|rcsb pdb:5MK4|rcsb pdb:5MKJ|rcsb pdb:5MKU|rcsb pdb:5MMW|rcsb pdb:5TBP|rcsb pdb:5UAN|rcsb pdb:5Z12|rcsb pdb:5ZQU|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6FBQ|rcsb pdb:6FBR|rcsb pdb:6HN6|rcsb pdb:6JNO|rcsb pdb:6JNR|rcsb pdb:6L6K|rcsb pdb:6LB4|rcsb pdb:6LB5|rcsb pdb:6LB6|rcsb pdb:6SJM|rcsb pdb:6STI|rcsb pdb:6XWG|rcsb pdb:6XWH|rcsb pdb:7A77|rcsb pdb:7B88|rcsb pdb:7B9O|rcsb pdb:7CFO|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-200425|reactome:R-HSA-204174|reactome:R-HSA-211976|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9616222|reactome:R-HSA-9623433|reactome:R-HSA-9632974|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:3R29 - - - comment:RXR was present in some, but not all, of the tested ChIP regions.|figure legend:Fig 5F.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 - rogid:gKnKFur3dYudXOAePzqRZJxqzYQ9606 intact-crc:EA580EE80B1D36F4 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) ensembl:ENSG00000077092 uniprotkb:P19793 intact:EBI-2610059 intact:EBI-78598|uniprotkb:Q2V504|uniprotkb:B3KY83|uniprotkb:Q2NL52|ensembl:ENSP00000419692 psi-mi:rarb_human_gene(display_short)|psi-mi:ENSG00000077092(display_long) psi-mi:rxra_human(display_long)|uniprotkb:RXRA(gene name)|psi-mi:RXRA(display_short)|uniprotkb:NR2B1(gene name synonym)|uniprotkb:Retinoid X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group B member 1(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610088|imex:IM-13602-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:NP_002948.1|refseq:NP_001278850.1|dip:DIP-641N|ensembl:ENSG00000186350(gene)|ensembl:ENST00000481739(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000003(Retinoid X receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021780|interpro:IPR035500|mint:P19793|rcsb pdb:1BY4|rcsb pdb:1DSZ|rcsb pdb:1FBY|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1G1U|rcsb pdb:1G5Y|rcsb pdb:1K74|rcsb pdb:1MV9|rcsb pdb:1MVC|rcsb pdb:1MZN|rcsb pdb:1R0N|rcsb pdb:1RDT|rcsb pdb:1RXR|rcsb pdb:1XLS|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YNW|rcsb pdb:2ACL|rcsb pdb:2NLL|rcsb pdb:2P1T|rcsb pdb:2P1U|rcsb pdb:2P1V|rcsb pdb:2ZXZ|rcsb pdb:2ZY0|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3E94|rcsb pdb:3FAL|rcsb pdb:3FC6|rcsb pdb:3FUG|rcsb pdb:3H0A|rcsb pdb:3KWY|rcsb pdb:3NSP|rcsb pdb:3NSQ|rcsb pdb:3OAP|rcsb pdb:3OZJ|rcsb pdb:3PCU|rcsb pdb:3R2A|rcsb pdb:3R5M|rcsb pdb:3UVV|rcsb pdb:4CN2|rcsb pdb:4CN3|rcsb pdb:4CN5|rcsb pdb:4CN7|rcsb pdb:4J5W|rcsb pdb:4J5X|rcsb pdb:4K4J|rcsb pdb:4K6I|rcsb pdb:4M8E|rcsb pdb:4M8H|rcsb pdb:4N5G|rcsb pdb:4N8R|rcsb pdb:4NQA|rcsb pdb:4OC7|rcsb pdb:4POH|rcsb pdb:4POJ|rcsb pdb:4PP3|rcsb pdb:4PP5|rcsb pdb:4RFW|rcsb pdb:4RMC|rcsb pdb:4RMD|rcsb pdb:4RME|rcsb pdb:4ZO1|rcsb pdb:4ZSH|rcsb pdb:5EC9|rcsb pdb:5JI0|rcsb pdb:5LYQ|rcsb pdb:5MJ5|rcsb pdb:5MK4|rcsb pdb:5MKJ|rcsb pdb:5MKU|rcsb pdb:5MMW|rcsb pdb:5TBP|rcsb pdb:5UAN|rcsb pdb:5Z12|rcsb pdb:5ZQU|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6FBQ|rcsb pdb:6FBR|rcsb pdb:6HN6|rcsb pdb:6JNO|rcsb pdb:6JNR|rcsb pdb:6L6K|rcsb pdb:6LB4|rcsb pdb:6LB5|rcsb pdb:6LB6|rcsb pdb:6SJM|rcsb pdb:6STI|rcsb pdb:6XWG|rcsb pdb:6XWH|rcsb pdb:7A77|rcsb pdb:7B88|rcsb pdb:7B9O|rcsb pdb:7CFO|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-200425|reactome:R-HSA-204174|reactome:R-HSA-211976|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9616222|reactome:R-HSA-9623433|reactome:R-HSA-9632974|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:3R29 - - - comment:RXR was present in some, but not all, of the tested ChIP regions.|figure legend:Fig 5F.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha) - 2010/03/09 2014/10/16 - rogid:gKnKFur3dYudXOAePzqRZJxqzYQ9606 intact-crc:F1524250FBBF7455 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610102|imex:IM-13602-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) psi-mi:"MI:0469"(intact) - - comment:"PML/RARa was immunoprecipitated by the anti-PU.1 antibody and vice versa, demonstrating that PML/RARa interacts with PU.1 in NB4 cells - (a cell line expressing the PML/RARa fusion protein)."|figure legend:Fig 6B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-nb4)|taxid:9606(Human NB4 APL cell line) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:0509316148C70BB4|rigid:7Umr4JxZGIy/qCtgljT+6IKMZgY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2610121|imex:IM-13602-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) psi-mi:"MI:0469"(intact) - - comment:"PML/RARa was immunoprecipitated by the anti-PU.1 antibody and vice versa, demonstrating that PML/RARa interacts with PU.1 in NB4 cells - (a cell line expressing the PML/RARa fusion protein)."|figure legend:Fig 6B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-nb4)|taxid:9606(Human NB4 APL cell line) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:D1713B374D080A00|rigid:7Umr4JxZGIy/qCtgljT+6IKMZgY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2610135|imex:IM-13602-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) go:"GO:0005634"(nucleus) - - comment:PU.1 and PML/RARa colocalized on microspeckles.|figure legend:Fig 6C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-nb4)|taxid:9606(Human NB4 APL cell line) - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:D6A8B97CB0BF2CA2|rigid:7Umr4JxZGIy/qCtgljT+6IKMZgY false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q15156 uniprotkb:P17947 intact:EBI-867256 intact:EBI-2293548|intact:EBI-28980694|ensembl:ENSP00000367799 psi-mi:q15156_human(display_long)|uniprotkb:PML-RAR(gene name)|psi-mi:PML-RAR(display_short) psi-mi:spi1_human(display_long)|uniprotkb:SPI1(gene name)|psi-mi:SPI1(display_short)|uniprotkb:31 kDa-transforming protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wang et al. (2010) imex:IM-13602|pubmed:20159610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2610161|imex:IM-13602-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021978|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR035500|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway) refseq:NP_001074016.1|refseq:NP_003111.2|ensembl:ENST00000227163|ensembl:ENSP00000227163|ensembl:ENSP00000367799|dip:DIP-953N|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-8939236|reactome:R-HSA-9616222|ensembl:ENSG00000066336(gene)|ensembl:ENST00000378538(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response) go:"GO:0005634"(nucleus) - - comment:PU.1 and PML/RARa colocalized on microspeckles.|figure legend:Fig 6C, S3.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-apl_blasts)|taxid:9606("Homo sapiens APL (Acute Promyelocytic Leukaemia )blasts") - 2010/03/09 2014/10/16 rogid:W2NJi+g0/Uu3Ixhet7kOSQq7ofQ9606 rogid:HmODprNJYXNKmGXiSJQt5/xTLY09606 intact-crc:BB5F54FD3E4A13F8|rigid:7Umr4JxZGIy/qCtgljT+6IKMZgY false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)