#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51825	uniprotkb:P50750	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610179|imex:IM-13603-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B.|comment:In the identification of AF4-associated proteins in vivo,  Mass spectrometry identified AFF4/AF5q31, ENL, CDK9, and cyclin T1 in the purified materials.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:DED04528C857AB5A|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P51825	uniprotkb:O60563	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610179|imex:IM-13603-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B.|comment:In the identification of AF4-associated proteins in vivo,  Mass spectrometry identified AFF4/AF5q31, ENL, CDK9, and cyclin T1 in the purified materials.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:DED04528C857AB5A|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P51825	uniprotkb:Q03111	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610179|imex:IM-13603-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B.|comment:In the identification of AF4-associated proteins in vivo,  Mass spectrometry identified AFF4/AF5q31, ENL, CDK9, and cyclin T1 in the purified materials.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:DED04528C857AB5A|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P51825	uniprotkb:Q9UHB7	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0004"(affinity chromatography technology)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610179|imex:IM-13603-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B.|comment:In the identification of AF4-associated proteins in vivo,  Mass spectrometry identified AFF4/AF5q31, ENL, CDK9, and cyclin T1 in the purified materials.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:DED04528C857AB5A|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O00255	uniprotkb:Q03164-PRO_0000390949	intact:EBI-592789|uniprotkb:O00632|uniprotkb:Q9BUK2|uniprotkb:A5HBC6|uniprotkb:A5HBC7|uniprotkb:A5HBC8|uniprotkb:A5HBC9|uniprotkb:A5HBD0|uniprotkb:A5HBD1|uniprotkb:A5HBD2|uniprotkb:Q9BUF0|ensembl:ENSP00000366530	intact:EBI-2610266	psi-mi:men1_human(display_long)|uniprotkb:MEN1(gene name)|psi-mi:MEN1(display_short)|uniprotkb:SCG2(gene name synonym)	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610215|imex:IM-13603-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000235.2|refseq:NP_570711.1|refseq:NP_570712.1|refseq:NP_570713.1|refseq:NP_570714.1|refseq:NP_570715.1|refseq:NP_570716.1|refseq:XP_005274058.1|refseq:XP_016873258.1|refseq:XP_016873259.1|dip:DIP-24236N|ensembl:ENSG00000133895(gene)|ensembl:ENST00000377313(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002076"(osteoblast development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046697"(decidualization)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|interpro:IPR007747(Menin)|mint:O00255|rcsb pdb:3U84|rcsb pdb:3U85|rcsb pdb:3U86|rcsb pdb:3U88|rcsb pdb:4GPQ|rcsb pdb:4GQ3|rcsb pdb:4GQ4|rcsb pdb:4GQ6|rcsb pdb:4I80|rcsb pdb:4OG3|rcsb pdb:4OG4|rcsb pdb:4OG5|rcsb pdb:4OG6|rcsb pdb:4OG7|rcsb pdb:4OG8|rcsb pdb:4X5Y|rcsb pdb:4X5Z|rcsb pdb:5DB0|rcsb pdb:5DB1|rcsb pdb:5DB2|rcsb pdb:5DB3|rcsb pdb:5DD9|rcsb pdb:5DDA|rcsb pdb:5DDB|rcsb pdb:5DDC|rcsb pdb:5DDD|rcsb pdb:5DDF|rcsb pdb:6B41|rcsb pdb:6BXH|rcsb pdb:6BXY|rcsb pdb:6BY8|rcsb pdb:6E1A|rcsb pdb:6O5I|rcsb pdb:6OPJ|rcsb pdb:6PKC|rcsb pdb:6WNH|reactome:R-HSA-201722|reactome:R-HSA-2173796|reactome:R-HSA-3769402|reactome:R-HSA-381426|reactome:R-HSA-5626467|reactome:R-HSA-8957275|rcsb pdb:5DDE	intact:EBI-591370(chain-parent)	psi-mi:"MI:0469"(intact)	-	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	figure legend:Fig 1C.|comment:MLL did not pull down AEP components in  K562 cells while coprecipitating menin, a component of the  MLL complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:gXAt4cxheS3wgMbFtc8ACfkHRH09606	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	intact-crc:A1D10AB8C36DEC37|rigid:jBf2lWBItxZ8385pkfdHhehUJZ4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q9UHB7	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610858|imex:IM-13603-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:E76D60CA5AE7D29B|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q03111	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610858|imex:IM-13603-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:E76D60CA5AE7D29B|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:P50750	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610858|imex:IM-13603-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:E76D60CA5AE7D29B|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:O60563	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610858|imex:IM-13603-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:E76D60CA5AE7D29B|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHB7	uniprotkb:P50750	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610867|imex:IM-13603-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:C716EEB8A176EAF0|rigid:xpnfoUErF+aodwIiyHsBUK9C/c4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHB7	uniprotkb:O60563	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610867|imex:IM-13603-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:C716EEB8A176EAF0|rigid:xpnfoUErF+aodwIiyHsBUK9C/c4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHB7	uniprotkb:Q03111	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610867|imex:IM-13603-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:C716EEB8A176EAF0|rigid:xpnfoUErF+aodwIiyHsBUK9C/c4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03111	uniprotkb:Q9UHB7	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610876|imex:IM-13603-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:E327C2437E8FCE32|rigid:xpnfoUErF+aodwIiyHsBUK9C/c4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03111	uniprotkb:O60563	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610876|imex:IM-13603-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:E327C2437E8FCE32|rigid:xpnfoUErF+aodwIiyHsBUK9C/c4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03111	uniprotkb:P50750	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610876|imex:IM-13603-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:E327C2437E8FCE32|rigid:xpnfoUErF+aodwIiyHsBUK9C/c4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390950	uniprotkb:Q03164-PRO_0000390949	intact:EBI-2638616	intact:EBI-2610266	psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614630|imex:IM-13603-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	intact:EBI-591370(chain-parent)	psi-mi:"MI:0469"(intact)	comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	intact-crc:87D8C071017F9950|rigid:q1KcxwyLfpQb0KRgdM6JnrxHhc4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50750	uniprotkb:P51825	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614664|imex:IM-13603-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	intact-crc:DC2838B891A01014|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50750	uniprotkb:O60563	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614664|imex:IM-13603-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:DC2838B891A01014|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50750	uniprotkb:Q03111	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614664|imex:IM-13603-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:DC2838B891A01014|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50750	uniprotkb:Q9UHB7	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614664|imex:IM-13603-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|comment:Reciprocal immunoprecipitation further confirmed that all five proteins compose an endogenous complex consistent with previous observations.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2010/03/11	2014/10/16	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:DC2838B891A01014|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHB7	uniprotkb:Q03111	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610308|imex:IM-13603-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A.|comment:AFF1/AF4, AFF4/AF5q31, and ENL associate in an endogenous higher-order complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ml_2)|taxid:9606(Homo sapiens ML-2 acute myeloid leukemia-derived cell line)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:3C0D9862F85C7262|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9UHB7	uniprotkb:P51825	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610308|imex:IM-13603-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A.|comment:AFF1/AF4, AFF4/AF5q31, and ENL associate in an endogenous higher-order complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ml_2)|taxid:9606(Homo sapiens ML-2 acute myeloid leukemia-derived cell line)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	intact-crc:3C0D9862F85C7262|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9UHB7	uniprotkb:O60563	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610308|imex:IM-13603-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A.|comment:AFF1/AF4, AFF4/AF5q31, and ENL associate in an endogenous higher-order complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ml_2)|taxid:9606(Homo sapiens ML-2 acute myeloid leukemia-derived cell line)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:3C0D9862F85C7262|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9UHB7	uniprotkb:P50750	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2610308|imex:IM-13603-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1A.|comment:AFF1/AF4, AFF4/AF5q31, and ENL associate in an endogenous higher-order complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ml_2)|taxid:9606(Homo sapiens ML-2 acute myeloid leukemia-derived cell line)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:3C0D9862F85C7262|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:Q2Q440	intact:EBI-2610266	intact:EBI-2638767	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:q2q440_human(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614734|imex:IM-13603-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	-	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:BJ0D0ui9Hc076WUW1r1Bi1IweUo9606	intact-crc:F3D108512887858D|rigid:YYQWVXkzmllC7nGVJZHMRiY7XOY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:Q9UHB7	intact:EBI-2610266	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614734|imex:IM-13603-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:F3D108512887858D|rigid:YYQWVXkzmllC7nGVJZHMRiY7XOY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:O60563	intact:EBI-2610266	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614734|imex:IM-13603-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:F3D108512887858D|rigid:YYQWVXkzmllC7nGVJZHMRiY7XOY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:P50750	intact:EBI-2610266	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614734|imex:IM-13603-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:F3D108512887858D|rigid:YYQWVXkzmllC7nGVJZHMRiY7XOY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:P51825	intact:EBI-2610266	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614734|imex:IM-13603-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	intact-crc:F3D108512887858D|rigid:YYQWVXkzmllC7nGVJZHMRiY7XOY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q03111	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614786|imex:IM-13603-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:58FC320DAF04B962|rigid:JtNQbxua/ePy0a9vMQqBjiRi39I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:O60563	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614786|imex:IM-13603-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:58FC320DAF04B962|rigid:JtNQbxua/ePy0a9vMQqBjiRi39I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q9UHB7	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614786|imex:IM-13603-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:58FC320DAF04B962|rigid:JtNQbxua/ePy0a9vMQqBjiRi39I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:P50750	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614786|imex:IM-13603-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:58FC320DAF04B962|rigid:JtNQbxua/ePy0a9vMQqBjiRi39I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q2Q440	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2638767	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:q2q440_human(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614786|imex:IM-13603-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	-	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hb1119)|taxid:9606(Homo sapiens acute lymphoblastic leukemia cell line HB1119)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:BJ0D0ui9Hc076WUW1r1Bi1IweUo9606	intact-crc:58FC320DAF04B962|rigid:JtNQbxua/ePy0a9vMQqBjiRi39I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:Q8TD98	intact:EBI-2610266	intact:EBI-2638899	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:q8td98_human(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614866|imex:IM-13603-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	interpro:IPR007797(AF-4 proto-oncoprotein)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR043639	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:f+HdRad9i3mscKfHdJ/n9MOLbTw9606	intact-crc:26B0701E0747EE45|rigid:sBkPrjieliAPJfHrDbtPb7+q95E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:Q03111	intact:EBI-2610266	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614866|imex:IM-13603-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:26B0701E0747EE45|rigid:sBkPrjieliAPJfHrDbtPb7+q95E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:P50750	intact:EBI-2610266	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614866|imex:IM-13603-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:26B0701E0747EE45|rigid:sBkPrjieliAPJfHrDbtPb7+q95E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:P51825	intact:EBI-2610266	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614866|imex:IM-13603-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	intact-crc:26B0701E0747EE45|rigid:sBkPrjieliAPJfHrDbtPb7+q95E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:O60563	intact:EBI-2610266	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614866|imex:IM-13603-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:26B0701E0747EE45|rigid:sBkPrjieliAPJfHrDbtPb7+q95E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q8TD98	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2638899	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:q8td98_human(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614890|imex:IM-13603-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	interpro:IPR007797(AF-4 proto-oncoprotein)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR043639	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:f+HdRad9i3mscKfHdJ/n9MOLbTw9606	intact-crc:308C6EFA152B15FE|rigid:9XL5vkPZZcNznNNPJPeTbTvl714	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q9UHB7	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614890|imex:IM-13603-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:308C6EFA152B15FE|rigid:9XL5vkPZZcNznNNPJPeTbTvl714	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:O60563	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614890|imex:IM-13603-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:308C6EFA152B15FE|rigid:9XL5vkPZZcNznNNPJPeTbTvl714	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:P50750	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614890|imex:IM-13603-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:308C6EFA152B15FE|rigid:9XL5vkPZZcNznNNPJPeTbTvl714	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q03111	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2614890|imex:IM-13603-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AF4, or MLL-AF5q31 showed that the respective fusion proteins form similar AEP-like complexes.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kp-l-ry)|taxid:9606("Human: KP-L-RY  leukemic blast cell line")	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:308C6EFA152B15FE|rigid:9XL5vkPZZcNznNNPJPeTbTvl714	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q1WD23	uniprotkb:Q03164-PRO_0000390949	intact:EBI-2638914	intact:EBI-2610266	psi-mi:q1wd23_human(display_long)|uniprotkb:MLL/AF6 fusion(gene name)|psi-mi:MLL/AF6 fusion(display_short)	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615282|imex:IM-13603-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000159(Ras-association)|go:"GO:0007165"(signal transduction)|interpro:IPR029071	intact:EBI-591370(chain-parent)	psi-mi:"MI:0469"(intact)	-	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	figure legend:Fig 1E.|comment:MLL-AF6, an MLL fusion with a cytoplasmic protein that was not copurified with AF4 or AF5q31, did not coprecipitate any of the AEP components in ML-2 cells. ML-2 cells have no normal MLL gene.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ml_2)|taxid:9606(Homo sapiens ML-2 acute myeloid leukemia-derived cell line)	-	2010/03/11	2014/10/16	rogid:VLDEZwr3Exs3h7nGwQcORzsrHwA9606	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	intact-crc:50F193F6617B3524|rigid:2bMYtxW4r9A/11ArmcIzyqMY0zg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q9UHB7	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615301|imex:IM-13603-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:MLL-AF6, an MLL fusion with a cytoplasmic protein that was not copurified with AF4 or AF5q31, did not coprecipitate any of the AEP components in ML-2 cells. ML-2 cells have no normal MLL gene.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ml_2)|taxid:9606(Homo sapiens ML-2 acute myeloid leukemia-derived cell line)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:659A1B624370D711|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q03111	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615301|imex:IM-13603-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:MLL-AF6, an MLL fusion with a cytoplasmic protein that was not copurified with AF4 or AF5q31, did not coprecipitate any of the AEP components in ML-2 cells. ML-2 cells have no normal MLL gene.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ml_2)|taxid:9606(Homo sapiens ML-2 acute myeloid leukemia-derived cell line)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:659A1B624370D711|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:P50750	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615301|imex:IM-13603-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:MLL-AF6, an MLL fusion with a cytoplasmic protein that was not copurified with AF4 or AF5q31, did not coprecipitate any of the AEP components in ML-2 cells. ML-2 cells have no normal MLL gene.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ml_2)|taxid:9606(Homo sapiens ML-2 acute myeloid leukemia-derived cell line)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:659A1B624370D711|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:O60563	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615301|imex:IM-13603-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|comment:MLL-AF6, an MLL fusion with a cytoplasmic protein that was not copurified with AF4 or AF5q31, did not coprecipitate any of the AEP components in ML-2 cells. ML-2 cells have no normal MLL gene.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ml_2)|taxid:9606(Homo sapiens ML-2 acute myeloid leukemia-derived cell line)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:659A1B624370D711|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:P50750	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619073|imex:IM-13603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3B.|comment:"P-TEFb interacts with AFF1/AF4 and AFF4/AF5q31 via subregion 1, which contains the N-terminal homology domain (NHD)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:CB99ED251EB84F1C|rigid:bUgS2T/4czlPCJ9YoOE1v16AxYE	false	fusion protein:?-?|flag tag:?-?|sufficient binding region:1-308	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:O60563	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619073|imex:IM-13603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3B.|comment:"P-TEFb interacts with AFF1/AF4 and AFF4/AF5q31 via subregion 1, which contains the N-terminal homology domain (NHD)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:CB99ED251EB84F1C|rigid:bUgS2T/4czlPCJ9YoOE1v16AxYE	false	fusion protein:?-?|flag tag:?-?|sufficient binding region:1-308	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHB7	uniprotkb:P50750	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619090|imex:IM-13603-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3B.|comment:"P-TEFb interacts with AFF1/AF4 and AFF4/AF5q31 via subregion 1, which contains the N-terminal homology domain (NHD)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:E4032B67474C00FD|rigid:Zdgl1aYvevagh7qTCfp8+BGg/xI	false	sufficient binding region:1-268|flag tag:?-?|fusion protein:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHB7	uniprotkb:O60563	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619090|imex:IM-13603-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3B.|comment:"P-TEFb interacts with AFF1/AF4 and AFF4/AF5q31 via subregion 1, which contains the N-terminal homology domain (NHD)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:E4032B67474C00FD|rigid:Zdgl1aYvevagh7qTCfp8+BGg/xI	false	sufficient binding region:1-268|flag tag:?-?|fusion protein:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03111	uniprotkb:Q9UHB7	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619177|imex:IM-13603-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 4B.|comment:"C-terminal ENL residues (494�559) are required for the interaction with (endogenous) AFF4/AF5q31."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:B263B8E7174BE6D1|rigid:8yo5gGl53DvVa76fgs8TC7rgRAI	false	mutation disrupting interaction:550-550|flag tag:?-?|fusion protein:?-?|necessary binding region:494-559	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHB7	uniprotkb:P42568	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619293|imex:IM-13603-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 4B.|comment:"C-terminal ENL residues (494�559) are required for the interaction with (endogenous) AFF4/AF5q31.  This (AHD) region is evolutionally conserved in AF9."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606	intact-crc:530A8C8F157736C5|rigid:HNS+1w79lNQ+SDFWgzyV4b8g5SQ	false	-	flag tag:?-?|mutation decreasing interaction:558-558|sufficient binding region:478-568|fusion protein:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TEK3	uniprotkb:P42568	intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657	intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0	psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym)	psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619207|imex:IM-13603-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N	refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 4D.|comment:"The AHD of ENL also mediated association with DOT1L. This (AHD) region is evolutionally conserved in AF9."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2018/09/18	rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606	rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606	intact-crc:0ACD409EB42EF721|rigid:3S4ueTEQ1DD/q/uOSiYepeT/8aY	false	ha tag:?-?	flag tag:?-?|mutation decreasing interaction:558-558|sufficient binding region:478-568|fusion protein:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TEK3	uniprotkb:Q03111	intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619240|imex:IM-13603-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 4D.|comment:The AHD of ENL also mediated association with DOT1L.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2018/09/18	rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:7F679208A37CCCD7|rigid:togL55jGAjMrhI7ayImQT45Skho	false	ha tag:?-?	mutation decreasing interaction:550-550|flag tag:?-?|fusion protein:?-?|sufficient binding region:494-559	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03111	uniprotkb:Q8TEK3	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619572|imex:IM-13603-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5A.|comment:ENL coprecipitated both AFF4/AF5q31 and DOT1L, but the latter two did not pull down each other, indicating that the three proteins do not form a trimeric complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2018/09/18	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606	intact-crc:7BE6B86B63F6CD18|rigid:togL55jGAjMrhI7ayImQT45Skho	false	fusion protein:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03111	uniprotkb:Q9UHB7	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619620|imex:IM-13603-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5A.|comment:ENL coprecipitated both AFF4/AF5q31 and DOT1L, but the latter two did not pull down each other, indicating that the three proteins do not form a trimeric complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2018/09/18	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:F7ACF0997260860C|rigid:nBC624ZNhbM6qKmbVedbKNK04lI	false	fusion protein:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03111	uniprotkb:Q8TEK3	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619620|imex:IM-13603-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5A.|comment:ENL coprecipitated both AFF4/AF5q31 and DOT1L, but the latter two did not pull down each other, indicating that the three proteins do not form a trimeric complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2018/09/18	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606	intact-crc:F7ACF0997260860C|rigid:nBC624ZNhbM6qKmbVedbKNK04lI	false	fusion protein:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03111	uniprotkb:Q9UHB7	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619634|imex:IM-13603-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5A.|comment:ENL coprecipitated both AFF4/AF5q31 and DOT1L, but the latter two did not pull down each other, indicating that the three proteins do not form a trimeric complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:C0FDE4AC63E202F1|rigid:8yo5gGl53DvVa76fgs8TC7rgRAI	false	fusion protein:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2620068	uniprotkb:Q8TEK3	-	intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657	psi-mi:mll_enl_human_protein(display_short)|psi-mi:EBI-2620068(display_long)	psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619670|imex:IM-13603-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q03111(multiple parent)|uniprotkb:Q03164(multiple parent)	refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 5C.|comment:FLAG-tagged MLL fusion proteins  were coexpressed with AFF1 or DOT1L.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2018/09/18	-	rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606	intact-crc:10A536D137931ABE	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2620068	uniprotkb:P51825	-	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	psi-mi:mll_enl_human_protein(display_short)|psi-mi:EBI-2620068(display_long)	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619670|imex:IM-13603-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q03111(multiple parent)|uniprotkb:Q03164(multiple parent)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 5C.|comment:FLAG-tagged MLL fusion proteins  were coexpressed with AFF1 or DOT1L.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2018/09/18	-	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	intact-crc:10A536D137931ABE	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2620075	uniprotkb:P51825	-	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	psi-mi:mll_aff4_fusion-1(display_short)|psi-mi:EBI-2620075(display_long)	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619680|imex:IM-13603-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q03164(multiple parent)|uniprotkb:Q9UHB7(multiple parent)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 5C.|comment:"Artificial MLL fusion protein (with AFF4)  that does  associate with AFF1."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	-	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	intact-crc:6DD8E8C2BF4B2F29	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51825	intact:EBI-2620048	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	-	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:mll_aff4_fusion(display_short)|psi-mi:EBI-2620048(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619925|imex:IM-13603-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	uniprotkb:Q03164(multiple parent)|uniprotkb:Q9UHB7(multiple parent)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig S3A.|comment:"Preferential hetero-dimerization was also observed in co-IP experiments of endogenous or transfected MLL-AFF4(AF5q31)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	-	intact-crc:18505B35114D009A	false	flag tag:?-?	fusion protein:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51825	uniprotkb:O60563	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619925|imex:IM-13603-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S3A.|comment:"Preferential hetero-dimerization was also observed in co-IP experiments of endogenous or transfected MLL-AFF4(AF5q31)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:18505B35114D009A	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UHB7	uniprotkb:O60563	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619975|imex:IM-13603-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S3A.|comment:"Preferential hetero-dimerization was also observed in co-IP experiments of endogenous or transfected MLL-AFF4(AF5q31)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:2AA5056E6953DFB4|rigid:mqb25v+is5FIaINLko09dapYGjc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8TEK3	uniprotkb:Q03111	intact:EBI-2619253|uniprotkb:O60379|uniprotkb:Q96JL1|ensembl:ENSP00000381657	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:dot1l_human(display_long)|uniprotkb:DOT1L(gene name)|psi-mi:DOT1L(display_short)|uniprotkb:KIAA1814(gene name synonym)|uniprotkb:KMT4(gene name synonym)|uniprotkb:Histone H3-K79 methyltransferase(gene name synonym)|uniprotkb:DOT1-like protein(gene name synonym)|uniprotkb:Lysine N-methyltransferase 4(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2620205|imex:IM-13603-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115871.1|interpro:IPR030445|mint:Q8TEK3|rcsb pdb:1NW3|rcsb pdb:2MV7|rcsb pdb:3QOW|rcsb pdb:3QOX|rcsb pdb:3SR4|rcsb pdb:3SX0|rcsb pdb:3UWP|rcsb pdb:4EK9|rcsb pdb:4EKG|rcsb pdb:4EKI|rcsb pdb:4EQZ|rcsb pdb:4ER0|rcsb pdb:4ER3|rcsb pdb:4ER5|rcsb pdb:4ER6|rcsb pdb:4ER7|rcsb pdb:4HRA|rcsb pdb:4WVL|rcsb pdb:5DRT|rcsb pdb:5DRY|rcsb pdb:5DSX|rcsb pdb:5DT2|rcsb pdb:5DTM|rcsb pdb:5DTQ|rcsb pdb:5DTR|rcsb pdb:5JUW|rcsb pdb:5MVS|rcsb pdb:5MW3|rcsb pdb:5MW4|rcsb pdb:6IN3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JN2|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NQA|rcsb pdb:6O96|rcsb pdb:6TE6|rcsb pdb:6TEL|rcsb pdb:6TEN|rcsb pdb:7BWD|rcsb pdb:7EDP|reactome:R-HSA-3214841|rcsb pdb:6NOG|ensembl:ENSG00000104885(gene)|ensembl:ENST00000398665(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0031151"("histone methyltransferase activity (H3-K79 specific)")|go:"GO:0032200"(telomere organization)|go:"GO:0005634"(nucleus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR021169|interpro:IPR025789|interpro:IPR029063|dip:DIP-56410N	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S4.|comment:AFF4 co-precipitates ENL but not DOT1L under  conditions where ENL pulls down DOT1L.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2018/09/18	rogid:AaD+YTOZFAyvyecKC/4b6An2pFA9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:31CF0DC8ABC837DB|rigid:togL55jGAjMrhI7ayImQT45Skho	false	ha tag:?-?	flag tag:?-?|fusion protein:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03111	uniprotkb:Q9UHB7	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2620224|imex:IM-13603-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S4.|comment:AFF4 co-precipitates ENL but not DOT1L under conditions where ENL pulls down DOT1L.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/11	2014/10/16	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:1D6FBBBF9165A819|rigid:8yo5gGl53DvVa76fgs8TC7rgRAI	false	flag tag:?-?|fusion protein:?-?	sufficient binding region:562-902|flag tag:?-?|fusion protein:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51825	uniprotkb:O60563	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619832|imex:IM-13603-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1B.|comment:"Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AFF1(AF4), or MLL-AFF1(AF5q31) showed that the respective fusion proteins form similar AEP-like complexes."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:378185ABB364A4C5|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:P50750	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619832|imex:IM-13603-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1B.|comment:"Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AFF1(AF4), or MLL-AFF1(AF5q31) showed that the respective fusion proteins form similar AEP-like complexes."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:378185ABB364A4C5|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q9UHB7	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619832|imex:IM-13603-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1B.|comment:"Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AFF1(AF4), or MLL-AFF1(AF5q31) showed that the respective fusion proteins form similar AEP-like complexes."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:378185ABB364A4C5|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51825	uniprotkb:Q03111	intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619832|imex:IM-13603-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1B.|comment:"Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AFF1(AF4), or MLL-AFF1(AF5q31) showed that the respective fusion proteins form similar AEP-like complexes."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM)	-	2010/03/11	2014/10/16	rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:378185ABB364A4C5|rigid:5AMQCHWG1QFyn2FQQk1rys58/nI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:Q9UHB7	intact:EBI-2610266	intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619840|imex:IM-13603-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig S1B.|comment:"Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AFF1(AF4), or MLL-AFF1(AF5q31) showed that the respective fusion proteins form similar AEP-like complexes."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM)	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606	intact-crc:942EBCA6F4C88262|rigid:QyTIL9qNDuJdZCNVi8Dj01j+fRY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:Q03111	intact:EBI-2610266	intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619840|imex:IM-13603-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig S1B.|comment:"Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AFF1(AF4), or MLL-AFF1(AF5q31) showed that the respective fusion proteins form similar AEP-like complexes."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM)	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606	intact-crc:942EBCA6F4C88262|rigid:QyTIL9qNDuJdZCNVi8Dj01j+fRY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:O60563	intact:EBI-2610266	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619840|imex:IM-13603-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig S1B.|comment:"Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AFF1(AF4), or MLL-AFF1(AF5q31) showed that the respective fusion proteins form similar AEP-like complexes."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM)	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	intact-crc:942EBCA6F4C88262|rigid:QyTIL9qNDuJdZCNVi8Dj01j+fRY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03164-PRO_0000390949	uniprotkb:P50750	intact:EBI-2610266	intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361	psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yokoyama et al. (2010)	imex:IM-13603|pubmed:20153263	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2619840|imex:IM-13603-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-591370(chain-parent)	refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA	psi-mi:"MI:0469"(intact)	comment:Amino acids 1 � 2718.  An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718	-	figure legend:Fig S1B.|comment:"Reciprocal IP using human leukemia cell lines that express MLL-ENL, MLL-AFF1(AF4), or MLL-AFF1(AF5q31) showed that the respective fusion proteins form similar AEP-like complexes."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sem)|taxid:9606(Human acute lymphoblastic leukemia cell line SEM)	-	2010/03/11	2014/10/16	rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606	rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606	intact-crc:942EBCA6F4C88262|rigid:QyTIL9qNDuJdZCNVi8Dj01j+fRY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)