#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:D3IUT5	uniprotkb:Q800K6	intact:EBI-2607396|uniprotkb:Q6GPQ1	intact:EBI-2607374|uniprotkb:B7ZSK6	psi-mi:ticrr_xenla(display_long)|uniprotkb:TopBP1-interacting checkpoint and replication regulator(gene name synonym)|uniprotkb:TopBP1-interacting, replication-stimulating protein(gene name synonym)|uniprotkb:ticrr(gene name)|psi-mi:ticrr(display_short)	psi-mi:tob1a_xenla(display_long)|uniprotkb:Cut5 protein(gene name synonym)|uniprotkb:DNA topoisomerase II-binding protein 1-A(gene name synonym)|uniprotkb:topbp1-A(gene name)|psi-mi:topbp1-A(display_short)|uniprotkb:cut5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kumagai et al. (2010)	imex:IM-13612|pubmed:20116089	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2607385|imex:IM-13612-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165777.1|interpro:IPR032746|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR026153	interpro:IPR044737|refseq:NP_001082568.1|interpro:IPR001357(BRCT)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019900"(kinase binding)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071165"(GINS complex assembly)|interpro:IPR035960|interpro:IPR036420	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/02	2014/10/16	rogid:KNzfVCg/rBDY+/WRxJIvuUPepxc8355	rogid:vlx+cVw5DN8q5VmM25UfN8q1MsE8355	intact-crc:E9C9B9D6167B6EEB|rigid:GYoWrgk7x01XTwqhYWOmfnJaXXs	false	-	ha tag:?-?|his tag:?-?|flag tag:c-c|sufficient binding region:1-1005,1485-1513	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q800K6	uniprotkb:D3IUT5	intact:EBI-2607374|uniprotkb:B7ZSK6	intact:EBI-2607396|uniprotkb:Q6GPQ1	psi-mi:tob1a_xenla(display_long)|uniprotkb:Cut5 protein(gene name synonym)|uniprotkb:DNA topoisomerase II-binding protein 1-A(gene name synonym)|uniprotkb:topbp1-A(gene name)|psi-mi:topbp1-A(display_short)|uniprotkb:cut5(gene name synonym)	psi-mi:ticrr_xenla(display_long)|uniprotkb:TopBP1-interacting checkpoint and replication regulator(gene name synonym)|uniprotkb:TopBP1-interacting, replication-stimulating protein(gene name synonym)|uniprotkb:ticrr(gene name)|psi-mi:ticrr(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kumagai et al. (2010)	imex:IM-13612|pubmed:20116089	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2607419|imex:IM-13612-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR044737|refseq:NP_001082568.1|interpro:IPR001357(BRCT)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019900"(kinase binding)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071165"(GINS complex assembly)|interpro:IPR035960|interpro:IPR036420	refseq:NP_001165777.1|interpro:IPR032746|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR026153	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C, 2D, 2E, 4C|inhibition:p27 CDKN1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/02	2014/10/16	rogid:vlx+cVw5DN8q5VmM25UfN8q1MsE8355	rogid:KNzfVCg/rBDY+/WRxJIvuUPepxc8355	intact-crc:2BA7043CBE8E7CF7|rigid:GYoWrgk7x01XTwqhYWOmfnJaXXs	false	ha tag:?-?|his tag:?-?|flag tag:c-c|necessary binding region:106-282	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q800K6	uniprotkb:D3IUT5	intact:EBI-2607374|uniprotkb:B7ZSK6	intact:EBI-2607396|uniprotkb:Q6GPQ1	psi-mi:tob1a_xenla(display_long)|uniprotkb:Cut5 protein(gene name synonym)|uniprotkb:DNA topoisomerase II-binding protein 1-A(gene name synonym)|uniprotkb:topbp1-A(gene name)|psi-mi:topbp1-A(display_short)|uniprotkb:cut5(gene name synonym)	psi-mi:ticrr_xenla(display_long)|uniprotkb:TopBP1-interacting checkpoint and replication regulator(gene name synonym)|uniprotkb:TopBP1-interacting, replication-stimulating protein(gene name synonym)|uniprotkb:ticrr(gene name)|psi-mi:ticrr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kumagai et al. (2010)	imex:IM-13612|pubmed:20116089	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2607544|imex:IM-13612-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR044737|refseq:NP_001082568.1|interpro:IPR001357(BRCT)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019900"(kinase binding)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071165"(GINS complex assembly)|interpro:IPR035960|interpro:IPR036420	refseq:NP_001165777.1|interpro:IPR032746|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR026153	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A, Supp. Fig. 3|inhibition:p27 CDKN1B|comment:Binding of Treslin to TopBP1 increases substantially near the commencement of DNA replication, triggered by addition of sperm nuclei extracts.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/03/02	2014/10/16	rogid:vlx+cVw5DN8q5VmM25UfN8q1MsE8355	rogid:KNzfVCg/rBDY+/WRxJIvuUPepxc8355	intact-crc:E1B069F58AF35221|rigid:GYoWrgk7x01XTwqhYWOmfnJaXXs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q800K6	uniprotkb:D3IUT5	intact:EBI-2607374|uniprotkb:B7ZSK6	intact:EBI-2607396|uniprotkb:Q6GPQ1	psi-mi:tob1a_xenla(display_long)|uniprotkb:Cut5 protein(gene name synonym)|uniprotkb:DNA topoisomerase II-binding protein 1-A(gene name synonym)|uniprotkb:topbp1-A(gene name)|psi-mi:topbp1-A(display_short)|uniprotkb:cut5(gene name synonym)	psi-mi:ticrr_xenla(display_long)|uniprotkb:TopBP1-interacting checkpoint and replication regulator(gene name synonym)|uniprotkb:TopBP1-interacting, replication-stimulating protein(gene name synonym)|uniprotkb:ticrr(gene name)|psi-mi:ticrr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kumagai et al. (2010)	imex:IM-13612|pubmed:20116089	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2607550|imex:IM-13612-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR044737|refseq:NP_001082568.1|interpro:IPR001357(BRCT)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019900"(kinase binding)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071165"(GINS complex assembly)|interpro:IPR035960|interpro:IPR036420	refseq:NP_001165777.1|interpro:IPR032746|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|interpro:IPR026153	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|inhibition:p27 CDKN1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/03/02	2014/10/16	rogid:vlx+cVw5DN8q5VmM25UfN8q1MsE8355	rogid:KNzfVCg/rBDY+/WRxJIvuUPepxc8355	intact-crc:6F05C421C1139C24|rigid:GYoWrgk7x01XTwqhYWOmfnJaXXs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)