#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z0E3	uniprotkb:P62318	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-372789|uniprotkb:P43331|uniprotkb:B5BU13|uniprotkb:B4DJP7|ensembl:ENSP00000215829|intact:EBI-10981086	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:smd3_human(display_long)|uniprotkb:SNRPD3(gene name)|psi-mi:SNRPD3(display_short)|uniprotkb:snRNP core protein D3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_004166.1|refseq:NP_001265585.1|ensembl:ENSG00000100028(gene)|ensembl:ENST00000215829(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005683"(U7 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:0071209"(U7 snRNA binding)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034099|mint:P62318|rcsb pdb:1D3B|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-111367|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-73856|reactome:R-HSA-77588|rcsb pdb:7ABG|rcsb pdb:3VRI|rcsb pdb:4PJO|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:3PGW|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6V4X|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|dip:DIP-31216N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:WkrSZVfVmSQrJYfy7mwp48xjsVA9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9BQG0	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-676973|intact:EBI-2559619|uniprotkb:Q86VM3|uniprotkb:Q9BW49|uniprotkb:Q9P0V5|uniprotkb:Q9UF99|ensembl:ENSP00000254718	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:mbb1a_human(display_long)|uniprotkb:MYBBP1A(gene name)|psi-mi:MYBBP1A(display_short)|uniprotkb:P160(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001099008.1|refseq:NP_055335.2|ensembl:ENST00000254718(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|ensembl:ENSG00000132382(gene)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q9BQG0|reactome:R-HSA-5250924	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:ScabTPXvbX/5VRsnaRQXUIlANow9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:O00567	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-396034|uniprotkb:Q2M3T6|uniprotkb:Q9NQ05|ensembl:ENSP00000370589	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:nop56_human(display_long)|uniprotkb:NOP56(gene name)|psi-mi:NOP56(display_short)|uniprotkb:NOL5A(gene name synonym)|uniprotkb:Nucleolar protein 5A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_006383.2|ensembl:ENSG00000101361(gene)|ensembl:ENST00000329276(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:O00567|reactome:R-HSA-390471|reactome:R-HSA-6790901|reactome:R-HSA-6791226	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:nXIsxj5Spl+kflK0yGJFykVylmA9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:O14980	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q86VP6	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-456077|uniprotkb:O94918|uniprotkb:Q6PIY4|uniprotkb:Q8NDJ4|uniprotkb:Q96JZ9|uniprotkb:Q96T19|uniprotkb:Q9BTC4|uniprotkb:Q9H0G2|uniprotkb:Q9P0H7|uniprotkb:Q9UF85|uniprotkb:B2RAU3|ensembl:ENSP00000442318	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:cand1_human(display_long)|uniprotkb:KIAA0829(gene name synonym)|uniprotkb:TIP120(gene name synonym)|uniprotkb:TIP120A(gene name synonym)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa A(gene name synonym)|uniprotkb:CAND1(gene name)|psi-mi:CAND1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_060918.2|dip:DIP-31608N|ensembl:ENSG00000111530(gene)|ensembl:ENST00000545606(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR039852|mint:Q86VP6|rcsb pdb:1U6G|rcsb pdb:4A0C|reactome:R-HSA-6798695|reactome:R-HSA-8951664|reactome:R-HSA-917937|interpro:IPR016024(Armadillo-type fold)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:2lBY8xJXlGZL+xyo/dyB2WzuNqs9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:O43592	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-286683|uniprotkb:A6NLH1|uniprotkb:O43784|uniprotkb:Q8WUG2|uniprotkb:Q9BVS7|ensembl:ENSP00000327821	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:xpot_human(display_long)|uniprotkb:tRNA exportin(gene name synonym)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:XPOT(gene name)|psi-mi:XPOT(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_009166.2|refseq:XP_016874237.1|ensembl:ENSG00000184575(gene)|ensembl:ENST00000332707(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040017|mint:O43592|reactome:R-HSA-6784531	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:S0p7em6zWNUHEuAYueP+ZTrKTKg9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q8N1F7	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-1042703|uniprotkb:Q14705|uniprotkb:B3KPQ8|ensembl:ENSP00000310668	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:nup93_human(display_long)|uniprotkb:NUP93(gene name)|psi-mi:NUP93(display_short)|uniprotkb:KIAA0095(gene name synonym)|uniprotkb:Nucleoporin Nup93(gene name synonym)|uniprotkb:93 kDa nucleoporin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_055484.3|refseq:NP_001229724.1|refseq:NP_001229725.1|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR007231(Nucleoporin interacting component)|mint:Q8N1F7|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|ensembl:ENSG00000102900(gene)|reactome:R-HSA-168271|ensembl:ENST00000308159(transcript)|go:"GO:0005635"(nuclear envelope)|reactome:R-HSA-168276|go:"GO:0005643"(nuclear pore)|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-191859|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005256320.1|dip:DIP-44020N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:pkk5pooUC4yQShpqjiwNLddfy149606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q96S59	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q93077	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-725259|uniprotkb:O00775|uniprotkb:O00776|uniprotkb:O00777|uniprotkb:O00778|uniprotkb:Q540R1|uniprotkb:B2R4F7|ensembl:ENSP00000321389|ensembl:ENSP00000367022|ensembl:ENSP00000473534	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:h2a1c_human(display_long)|uniprotkb:H2AC6(gene name)|psi-mi:H2AC6(display_short)|uniprotkb:H2A-clustered histone 6(gene name synonym)|uniprotkb:H2AFL(gene name synonym)|uniprotkb:HIST1H2AC(gene name synonym)|uniprotkb:Histone H2A/l(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_003503.1|ensembl:ENSG00000180573(gene)|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|ensembl:ENST00000314088(transcript)|ensembl:ENST00000377791(transcript)|ensembl:ENST00000602637(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|rcsb pdb:6C0W|rcsb pdb:6MUO|rcsb pdb:6MUP|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:7A08|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|interpro:IPR032458	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:m00IdooZksbNGKHSsaVvGFVpcko9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q92841	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-746012|uniprotkb:Q69YT1|uniprotkb:Q6ICD6|uniprotkb:H3BLZ8|uniprotkb:B1AHM0|ensembl:ENSP00000385536	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ddx17_human(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:RNA-dependent helicase p72(gene name synonym)|uniprotkb:DEAD box protein p72(gene name synonym)|uniprotkb:DDX17(gene name)|psi-mi:DDX17(display_short)|uniprotkb:DEAD box protein p82(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_006377.2|ensembl:ENSG00000100201(gene)|ensembl:ENST00000403230(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q92841|rcsb pdb:6UV0|rcsb pdb:6UV1|rcsb pdb:6UV2|rcsb pdb:6UV3|rcsb pdb:6UV4|reactome:R-HSA-3899300|dip:DIP-29843N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:3UhUuhRSZg/zlM7UPDKYCqNmUho9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q14974	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P49792	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-973138|intact:EBI-28970106|ensembl:ENSP00000283195|uniprotkb:Q13074|uniprotkb:Q15280|uniprotkb:Q53TE2|uniprotkb:Q59FH7	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rbp2_human(display_long)|uniprotkb:RANBP2(gene name)|psi-mi:RANBP2(display_short)|uniprotkb:NUP358(gene name synonym)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Nuclear pore complex protein Nup358(gene name synonym)|uniprotkb:Nucleoporin Nup358(gene name synonym)|uniprotkb:358 kDa nucleoporin(gene name synonym)|uniprotkb:p270(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000153201(gene)|ensembl:ENST00000283195(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|reactome:R-HSA-168271|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:P49792|reactome:R-HSA-168276|rcsb pdb:1RRP|reactome:R-HSA-168325|reactome:R-HSA-168333|rcsb pdb:1XKE|rcsb pdb:1Z5S|rcsb pdb:2LAS|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4GA0|rcsb pdb:4I9Y|rcsb pdb:4L6E|rcsb pdb:4LQW|rcsb pdb:5CLL|rcsb pdb:5CLQ|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-170822|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-180746|reactome:R-HSA-9648025|ensembl:ENSP00000283195|refseq:NP_006258.3|dip:DIP-37654N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:KB+rjfw8djVygvDpTncA0NO2MDY9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P14678	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-372458|uniprotkb:Q15490|uniprotkb:Q9UIS5|uniprotkb:Q6IB35|ensembl:ENSP00000412566	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rsmb_human(display_long)|uniprotkb:Sm protein B/B'(gene name synonym)|uniprotkb:SNRPB(gene name)|psi-mi:SNRPB(display_short)|uniprotkb:COD(gene name synonym)|uniprotkb:SNRPB1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_003082.1|refseq:NP_937859.1|ensembl:ENSG00000125835(gene)|ensembl:ENST00000438552(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005683"(U7 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007420"(brain development)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:1990446"(U1 snRNP binding)|go:"GO:1990447"(U2 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR017131(Small ribonucleoprotein associated, SmB/SmN)|mint:P14678|rcsb pdb:1D3B|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4PJO|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6V4X|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-111367|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-73856|reactome:R-HSA-77588|dip:DIP-31239N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:zm9vJCpHG8w5iKErbOphUDCXTPk9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P17844	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q15029	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-357897|uniprotkb:Q9BUR0|uniprotkb:D3DX58|uniprotkb:B4DK30|ensembl:ENSP00000392094|ensembl:ENSP00000467805|uniprotkb:B4DMC0|uniprotkb:K7EJ81	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:u5s1_human(display_long)|uniprotkb:EFTUD2(gene name)|psi-mi:EFTUD2(display_short)|uniprotkb:KIAA0031(gene name synonym)|uniprotkb:SNRP116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)|uniprotkb:SNU114 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001136077.1|refseq:NP_004238.3|refseq:NP_001245282.1|go:"GO:0042220"(response to cocaine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:Q15029|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|go:"GO:0035690"|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000108883(gene)|ensembl:ENST00000426333(transcript)|ensembl:ENST00000591382(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|refseq:NP_001245283.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:/dBQ7TFnGr31AYrb5e215eQ4vfc9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q8TEQ6	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-443630|ensembl:ENSP00000285873|uniprotkb:Q14CV0|uniprotkb:Q8WWV4|uniprotkb:Q969W4|uniprotkb:Q9H9K3|uniprotkb:Q9UFI5	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:gemi5_human(display_long)|uniprotkb:GEMIN5(gene name)|psi-mi:GEMIN5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000082516(gene)|ensembl:ENST00000285873(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0017069"(snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0032797"(SMN complex)|go:"GO:0034718"(SMN-Gemin2 complex)|interpro:IPR036322|mint:Q8TEQ6|go:"GO:0034719"(SMN-Sm protein complex)|rcsb pdb:5GXH|rcsb pdb:5GXI|rcsb pdb:5H1J|rcsb pdb:5H1K|go:"GO:0043022"(ribosome binding)|rcsb pdb:5H1L|rcsb pdb:5H1M|rcsb pdb:5H3S|rcsb pdb:5H3T|rcsb pdb:5H3U|rcsb pdb:5TEE|rcsb pdb:5TEF|rcsb pdb:5THA|rcsb pdb:6RNQ|rcsb pdb:6RNS|reactome:R-HSA-191859|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|refseq:NP_056280.2|refseq:NP_001239085.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:9D6k6KGv+klNdYzgQClnthCYJuo9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:O95373	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q14566	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P23527	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-1642161|uniprotkb:Q3KPI7|uniprotkb:Q8TCV6|ensembl:ENSP00000477527	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:h2b1o_human(display_long)|uniprotkb:H2BC17(gene name)|psi-mi:H2BC17(display_short)|uniprotkb:H2B-clustered histone 17(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFN(gene name synonym)|uniprotkb:HIST1H2BO(gene name synonym)|uniprotkb:Histone H2B.2(gene name synonym)|uniprotkb:Histone H2B.n(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_003518.2|ensembl:ENSG00000274641(gene)|ensembl:ENST00000616182(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P23527|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:vetsoCf1s6GUePoGq1wMLwz8obg9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9UQE7	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-80718|ensembl:ENSP00000354720|uniprotkb:O60464|uniprotkb:Q5T482|uniprotkb:A8K156	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:smc3_human(display_long)|uniprotkb:SMC3(gene name)|psi-mi:SMC3(display_short)|uniprotkb:BAM(gene name synonym)|uniprotkb:SMC3L1(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome-associated polypeptide(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:BMH(gene name synonym)|uniprotkb:CSPG6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9UQE7|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|go:"GO:0070840"(dynein complex binding)|ensembl:ENSG00000108055(gene)|ensembl:ENST00000361804(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|refseq:NP_005436.1|dip:DIP-29200N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:pUxr+sTtttRzGlqCRz/25woNtrg9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P33992	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P49736	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P52701	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-395529|uniprotkb:O43706|uniprotkb:O43917|uniprotkb:Q8TCX4|uniprotkb:Q9BTB5|ensembl:ENSP00000234420|uniprotkb:B4DF41|uniprotkb:B4E3I4|uniprotkb:F5H2F9	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:msh6_human(display_long)|uniprotkb:MSH6(gene name)|psi-mi:MSH6(display_short)|uniprotkb:MutS-alpha 160 kDa subunit(gene name synonym)|uniprotkb:G/T mismatch-binding protein(gene name synonym)|uniprotkb:GTBP(gene name synonym)|uniprotkb:MutS protein homolog 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_000170.1|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019899"(enzyme binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR017261(DNA mismatch repair protein Msh6)|interpro:IPR027417|interpro:IPR036187|interpro:IPR036678|mint:P52701|rcsb pdb:2GFU|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:6OQM|reactome:R-HSA-5358565|reactome:R-HSA-5632928|reactome:R-HSA-5632968|ensembl:ENSG00000116062(gene)|ensembl:ENST00000234420(transcript)|refseq:NP_001268421.1|refseq:NP_001268422.1|refseq:NP_001268423.1|dip:DIP-32972N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:YPpiWmh4fSjXapWgA/rXbMrLAGg9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q16695	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-358900|uniprotkb:Q6FGU4|uniprotkb:B2R5K3|ensembl:ENSP00000355657|ensembl:ENSP00000494070	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:h31t_human(display_long)|uniprotkb:H3-4(gene name)|psi-mi:H3-4(display_short)|uniprotkb:H3/g(gene name synonym)|uniprotkb:H3FT(gene name synonym)|uniprotkb:HIST3H3(gene name synonym)|uniprotkb:Histone H3.4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_003484.1|ensembl:ENSG00000168148(gene)|ensembl:ENSG00000285435(gene)|ensembl:ENST00000366696(transcript)|ensembl:ENST00000644869(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q16695|rcsb pdb:2V1D|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3A6N|rcsb pdb:3T6R|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:6OIE|rcsb pdb:6WAT|rcsb pdb:6WAU|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-201722|reactome:R-HSA-2299718|reactome:R-HSA-2559586|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-9670095|dip:DIP-922N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:izXHIcNCPCDQ7yevMtqWxTRt1bA9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q8TD26	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-1043681|uniprotkb:Q5JYQ0|uniprotkb:Q5TGZ9|uniprotkb:Q5TH00|uniprotkb:Q5TH01|uniprotkb:Q8IZR2|uniprotkb:Q8WTY0|uniprotkb:Q9H4H6|uniprotkb:Q9H6D4|uniprotkb:Q9NTT7|uniprotkb:Q9P2L1|ensembl:ENSP00000362330	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:chd6_human(display_long)|uniprotkb:CHD6(gene name)|psi-mi:CHD6(display_short)|uniprotkb:CHD5(gene name synonym)|uniprotkb:KIAA1335(gene name synonym)|uniprotkb:RIGB(gene name synonym)|uniprotkb:ATP-dependent helicase CHD6(gene name synonym)|uniprotkb:Radiation-induced gene B protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000124177(gene)|ensembl:ENST00000373233(transcript)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|go:"GO:0001221"(transcription coregulator binding)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0003677"(DNA binding)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|go:"GO:0003678"(DNA helicase activity)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR037259|interpro:IPR038718|mint:Q8TD26|rcsb pdb:2EPB|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|refseq:NP_115597.3	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:3OZYCM6IRFVXZHCvEycD2Ha8gKI9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P49321	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-716205|uniprotkb:Q53GW5|uniprotkb:Q5T625|uniprotkb:Q5T622|uniprotkb:Q96A69|uniprotkb:Q9BTW2|uniprotkb:A8K6H2|uniprotkb:B4DQP3|uniprotkb:F5H3J2|uniprotkb:D3DQ07|intact:EBI-28989159|ensembl:ENSP00000255120	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:nasp_human(display_long)|uniprotkb:NASP(gene name)|psi-mi:NASP(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001182122.1|refseq:NP_002473.2|refseq:NP_689511.2|ensembl:ENSG00000132780(gene)|ensembl:ENST00000350030(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0008584"(male gonad development)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019544|interpro:IPR019734|mint:P49321|ensembl:ENSP00000255120|ensembl:ENST00000351223|ensembl:ENSP00000255121|ensembl:ENST00000537798|ensembl:ENSP00000438871|refseq:XP_005270945.1|dip:DIP-47269N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:8BOknyp+vOh6NF+fXZPYbbqFbH49606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:O60216	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-80739|ensembl:ENSP00000297338|uniprotkb:Q15001|uniprotkb:Q99568|uniprotkb:A8K0E0	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rad21_human(display_long)|uniprotkb:RAD21(gene name)|psi-mi:RAD21(display_short)|uniprotkb:HR21(gene name synonym)|uniprotkb:KIAA0078(gene name synonym)|uniprotkb:Nuclear matrix protein 1(gene name synonym)|uniprotkb:SCC1 homolog(gene name synonym)|uniprotkb:NXP1(gene name synonym)|uniprotkb:SCC1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000164754(gene)|ensembl:ENST00000297338(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008278"(cohesin complex)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O60216|rcsb pdb:4PJU|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|rcsb pdb:4PJW|rcsb pdb:4PK7|rcsb pdb:6QNX|rcsb pdb:6RRC|reactome:R-HSA-2468052|rcsb pdb:6RRK|reactome:R-HSA-2470946|rcsb pdb:6WG3|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|refseq:NP_006256.1|dip:DIP-29201N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:9H+Fipb91zQo7ie3YHCL7Ardveo9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P12004	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q14683	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-80690|ensembl:ENSP00000323421|uniprotkb:O14995|uniprotkb:Q16351|uniprotkb:Q2M228	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:smc1a_human(display_long)|uniprotkb:SMC1A(gene name)|psi-mi:SMC1A(display_short)|uniprotkb:DXS423E(gene name synonym)|uniprotkb:KIAA0178(gene name synonym)|uniprotkb:SB1.8(gene name synonym)|uniprotkb:SMC1(gene name synonym)|uniprotkb:SMC1L1(gene name synonym)|uniprotkb:Sb1.8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000072501(gene)|ensembl:ENST00000322213(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR029683|interpro:IPR036277|mint:Q14683|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|reactome:R-HSA-2468052|refseq:NP_006297.2|dip:DIP-30911N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:0UhfA7txIetlcGvSes6d+Bv1ZdY9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q13263	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P20700	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-968218|ensembl:ENSP00000261366|uniprotkb:Q3SYN7|uniprotkb:Q96EI6|uniprotkb:B2R6J6	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:lmnb1_human(display_long)|uniprotkb:LMNB1(gene name)|psi-mi:LMNB1(display_short)|uniprotkb:LMN2(gene name synonym)|uniprotkb:LMNB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000113368(gene)|ensembl:ENST00000261366(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P20700|rcsb pdb:2KPW|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3JT0|rcsb pdb:3TYY|rcsb pdb:3UMN|rcsb pdb:5VVX|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|reactome:R-HSA-2559584|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-4419969|reactome:R-HSA-8862803|reactome:R-HSA-8950505|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:NP_005564.1|dip:DIP-34897N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:ZLv4OS5VSmn3sdXB9IP98YdQ+Iw9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P78527	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9Y230	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9Y5B9	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-1046849|uniprotkb:Q6GMT8|uniprotkb:Q6P2F1|uniprotkb:Q6PJM1|uniprotkb:Q9NRX0|ensembl:ENSP00000216297	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:sp16h_human(display_long)|uniprotkb:Facilitates chromatin transcription complex subunit SPT16(gene name synonym)|uniprotkb:FACT 140 kDa subunit(gene name synonym)|uniprotkb:FACTp140(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 140 kDa subunit(gene name synonym)|uniprotkb:SUPT16H(gene name)|psi-mi:SUPT16H(display_short)|uniprotkb:FACT140(gene name synonym)|uniprotkb:FACTP140(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000092201(gene)|ensembl:ENST00000216297(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034724"(DNA replication-independent chromatin organization)|go:"GO:0035101"(FACT complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR013953(FACT complex subunit Spt16p/Cdc68p)|interpro:IPR029148|interpro:IPR029149|interpro:IPR033825|interpro:IPR036005|interpro:IPR040258|mint:Q9Y5B9|rcsb pdb:4Z2M|rcsb pdb:4Z2N|rcsb pdb:5E5B|rcsb pdb:5UMT|rcsb pdb:5UMU|rcsb pdb:5XM2|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|refseq:NP_009123.1|dip:DIP-42757N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:jLK5dOF3mEyI0UbZhcNgtdlG+WI9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P30876	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-394712|uniprotkb:Q8IZ61|uniprotkb:A8K1A8|ensembl:ENSP00000312735|ensembl:ENSP00000370625	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rpb2_human(display_long)|uniprotkb:POLR2B(gene name)|psi-mi:POLR2B(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit B(gene name synonym)|uniprotkb:RNA polymerase II subunit B2(gene name synonym)|uniprotkb:RNA polymerase II subunit 2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 140 kDa polypeptide(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_000929.1|refseq:NP_001290197.1|refseq:NP_001290198.1|ensembl:ENSG00000047315(gene)|ensembl:ENST00000314595(transcript)|ensembl:ENST00000381227(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR007646(RNA polymerase Rpb2, domain 4)|interpro:IPR007647(RNA polymerase Rpb2, domain 5)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR037033|interpro:IPR037034|mint:P30876|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32910N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:YhEjtfLk2QnbRPefOp8ZHX0ejak9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P43246	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P11388	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P24928	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P09874	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q07021	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q92616	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-356221|ensembl:ENSP00000300648|uniprotkb:O95001|uniprotkb:O95651|uniprotkb:Q6P2S3|uniprotkb:Q86X65|uniprotkb:Q8N5I5|uniprotkb:Q8WU80|uniprotkb:Q99736|uniprotkb:Q9UE60|uniprotkb:A8KAY1|intact:EBI-1058692	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:gcn1_human(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:GCN1 eIF-2-alpha kinase activator homolog(gene name synonym)|uniprotkb:GCN1-like protein 1(gene name synonym)|uniprotkb:GCN1L1(gene name synonym)|uniprotkb:General control of amino-acid synthesis 1-like protein 1(gene name synonym)|uniprotkb:KIAA0219(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000089154(gene)|ensembl:ENST00000300648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR033173|interpro:IPR034085|mint:Q92616|reactome:R-HSA-9633012|go:"GO:0005844"(polysome)|refseq:NP_006827.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:NtSEW6xjvCkUyb40cnk0JdL5PcA9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P11940	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:XudTSPq2h9ckKAc48X88RVafPRU9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P84103	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-372557|uniprotkb:P23152|uniprotkb:O08831|uniprotkb:B4E241|intact:EBI-11020748|uniprotkb:Q5R3K0|ensembl:ENSP00000362820|ensembl:ENSP00000482833	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:srsf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP20(gene name synonym)|uniprotkb:SRSF3(gene name)|psi-mi:SRSF3(display_short)|uniprotkb:SRP20(gene name synonym)|uniprotkb:SFRS3(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_003008.1|ensembl:ENSG00000112081(gene)|ensembl:ENST00000373715(transcript)|ensembl:ENST00000620941(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016607"(nuclear speck)|go:"GO:0043274"(phospholipase binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P84103|rcsb pdb:2I2Y|rcsb pdb:2I38|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|dip:DIP-32961N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:BcfyCj2cNNTH1igANKpvh4IHDVU9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q01130	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q07955	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549710|imex:IM-13587-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	intact-crc:3CD0A0FAE7C75641|rigid:0Wlw33UxAgTpWnQyk8ka7W8VfyU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P27048	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-309845|uniprotkb:Q3UJT1|ensembl:ENSMUSP00000099488	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rsmb_mouse(display_long)|uniprotkb:Snrpb(gene name)|psi-mi:Snrpb(display_short)|uniprotkb:Sm protein B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_033251.1|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007420"(brain development)|go:"GO:0034709"(methylosome)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:1990446"(U1 snRNP binding)|go:"GO:1990447"(U2 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR017131(Small ribonucleoprotein associated, SmB/SmN)|mint:P27048|reactome:R-MMU-111367|reactome:R-MMU-191859|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-73856|reactome:R-MMU-77588|ensembl:ENSMUSG00000027404(gene)|ensembl:ENSMUST00000103199(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005683"(U7 snRNP)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:HdsrtiDvbyp7PS28aVRTvH0SecY10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:O08810	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550333|ensembl:ENSMUSP00000102675	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:u5s1_mouse(display_long)|uniprotkb:Eftud2(gene name)|psi-mi:Eftud2(display_short)|uniprotkb:Snrp116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000020929(gene)|ensembl:ENSMUST00000107060(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:O08810|reactome:R-MMU-72163|reactome:R-MMU-72165|refseq:NP_001103465.1|refseq:NP_035561.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:BXx/oB92nIw8mcrZHvpWc+E+DFA10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q3UHQ5	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550458	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:q3uhq5_mouse(display_long)|uniprotkb:Gcn1(gene name)|psi-mi:Gcn1(display_short)|uniprotkb:Gcn1l1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	go:"GO:0006417"(regulation of translation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043022"(ribosome binding)|refseq:NP_766307.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|interpro:IPR021133|interpro:IPR033173|interpro:IPR034085	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:1t/G1ybGLV/oHg/3GijS0N8AWjk10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q8BX17	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550292|uniprotkb:Q3UPH2|ensembl:ENSMUSP00000036603	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:gemi5_mouse(display_long)|uniprotkb:Gemin5(gene name)|psi-mi:Gemin5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000037275(gene)|ensembl:ENSMUST00000035604(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0016604"(nuclear body)|go:"GO:0017069"(snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0032797"(SMN complex)|go:"GO:0034718"(SMN-Gemin2 complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|reactome:R-MMU-191859|refseq:NP_001160141.1|refseq:NP_001160142.1|refseq:NP_001160143.1|refseq:NP_766146.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:a2dQ9yhjRVYev2Iml4Zgj8PQi6s10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P29341	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-773902|uniprotkb:Q99L36|ensembl:ENSMUSP00000001809	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:pabp1_mouse(display_long)|uniprotkb:Pabpc1(gene name)|psi-mi:Pabpc1(display_short)|uniprotkb:Pabp1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	dip:DIP-32127N|refseq:NP_032800.2|refseq:XP_011243641.1|ensembl:ENSMUSG00000022283(gene)|ensembl:ENSMUST00000001809(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045202"(synapse)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P29341|reactome:R-MMU-156827|reactome:R-MMU-429947|reactome:R-MMU-450408|reactome:R-MMU-72649|reactome:R-MMU-975956|reactome:R-MMU-975957	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:jvlQW6kphF2tkZwK72DtAXDPHvs10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q6PDM2	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550360|ensembl:ENSMUSP00000120595|uniprotkb:B2KGJ5|uniprotkb:Q3UCH2|uniprotkb:Q5SXC5|uniprotkb:Q8BJV3|uniprotkb:Q8C1H9	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:srsf1_mouse(display_long)|uniprotkb:Sfrs1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)|uniprotkb:Srsf1(gene name)|psi-mi:Srsf1(display_short)|uniprotkb:ASF/SF2(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRp30a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000018379(gene)|ensembl:ENSMUST00000139129(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0050733"(RS domain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q6PDM2|rcsb pdb:1X4C|go:"GO:0005654"(nucleoplasm)|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-72165|refseq:NP_001071635.1|refseq:NP_775550.2|dip:DIP-48723N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q8BJ71	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550206|ensembl:ENSMUSP00000078878|ensembl:ENSMUSP00000105174|ensembl:ENSMUSP00000148700|uniprotkb:Q3TED9|uniprotkb:Q8BIK7|uniprotkb:Q8K1R4|uniprotkb:Q8R592	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:nup93_mouse(display_long)|uniprotkb:Nup93(gene name)|psi-mi:Nup93(display_short)|uniprotkb:Cip4(gene name synonym)|uniprotkb:Kiaa0095(gene name synonym)|uniprotkb:Nucleoporin Nup93(gene name synonym)|uniprotkb:93 kDa nucleoporin(gene name synonym)|uniprotkb:CBP-interacting protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000032939(gene)|ensembl:ENSMUST00000079961(transcript)|ensembl:ENSMUST00000109547(transcript)|ensembl:ENSMUST00000212824(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005813"(centrosome)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR007231(Nucleoporin interacting component)|mint:Q8BJ71|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822|reactome:R-MMU-191859|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-9615933|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|refseq:NP_765998.1|refseq:XP_006531437.1|refseq:XP_006531438.1|refseq:XP_006531439.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:WvpVQMDhHGIOUStAtglTjVfqUc810090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P84104	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550426|ensembl:ENSMUSP00000117045|uniprotkb:O08831|uniprotkb:P23152|uniprotkb:Q564E9	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:srsf3_mouse(display_long)|uniprotkb:Sfrs3(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 3(gene name synonym)|uniprotkb:Srsf3(gene name)|psi-mi:Srsf3(display_short)|uniprotkb:Srp20(gene name synonym)|uniprotkb:X16(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRP20(gene name synonym)|uniprotkb:Protein X16(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000071172(gene)|ensembl:ENSMUST00000130216(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0043274"(phospholipase binding)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P84104|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|refseq:NP_038691.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:BcfyCj2cNNTH1igANKpvh4IHDVU10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9D6Z1	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-527254|uniprotkb:Q3UD45|uniprotkb:Q8BVL1|uniprotkb:Q8VDT2|uniprotkb:Q99LT8|uniprotkb:Q9CT15|ensembl:ENSMUSP00000099487	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:nop56_mouse(display_long)|uniprotkb:Nop56(gene name)|psi-mi:Nop56(display_short)|uniprotkb:Nol5a(gene name synonym)|uniprotkb:Nucleolar protein 5A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_077155.2|ensembl:ENSMUSG00000027405(gene)|ensembl:ENSMUST00000103198(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:Q9D6Z1|reactome:R-MMU-6791226	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:5darNL7hBt/XPnvcm0hiVxx7WDY10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q7TPV4	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-1373622|uniprotkb:O35851|uniprotkb:Q80Y66|uniprotkb:Q8R4X2|uniprotkb:Q99KP0|ensembl:ENSMUSP00000044827	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:mbb1a_mouse(display_long)|uniprotkb:Mybbp1a(gene name)|psi-mi:Mybbp1a(display_short)|uniprotkb:P160(gene name synonym)|uniprotkb:Myb-binding protein of 160 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_058056.2|dip:DIP-39831N|ensembl:ENSMUSG00000040463(gene)|ensembl:ENSMUST00000045633(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR016024(Armadillo-type fold)|mint:Q7TPV4|reactome:R-MMU-5250924	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:rt1TQLZB7JNBkpt3DooDAlzOYCo10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P68433	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-79743|ensembl:ENSMUSP00000079670|ensembl:ENSMUSP00000089293|ensembl:ENSMUSP00000139663|ensembl:ENSMUSP00000140394|uniprotkb:Q05A97|uniprotkb:P02295|uniprotkb:P02296|uniprotkb:P16106|uniprotkb:Q3B7Z8|uniprotkb:Q3B7Z9|uniprotkb:Q5T009	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:h31_mouse(display_long)|uniprotkb:H3c1(gene name)|psi-mi:H3c1(display_short)|uniprotkb:H3c10(gene name)|psi-mi:H3c10(display_short)|uniprotkb:H3c11(gene name)|psi-mi:H3c11(display_short)|uniprotkb:H3c8(gene name)|psi-mi:H3c8(display_short)|uniprotkb:H3.1-221(gene name synonym)|uniprotkb:H3.1-291(gene name synonym)|uniprotkb:H3.1-I(gene name synonym)|uniprotkb:H3a(gene name synonym)|uniprotkb:H3g(gene name synonym)|uniprotkb:H3h(gene name synonym)|uniprotkb:H3i(gene name synonym)|uniprotkb:Hist1h3a(gene name synonym)|uniprotkb:Hist1h3g(gene name synonym)|uniprotkb:Hist1h3h(gene name synonym)|uniprotkb:Hist1h3i(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000069265(gene)|ensembl:ENSMUSG00000099517(gene)|ensembl:ENSMUSG00000101355(gene)|ensembl:ENSMUSG00000101972(gene)|ensembl:ENSMUST00000080859(transcript)|ensembl:ENSMUST00000091701(transcript)|ensembl:ENSMUST00000188775(transcript)|ensembl:ENSMUST00000189457(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060968"(obsolete regulation of gene silencing)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1GUW|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-3247509|reactome:R-MMU-427359|rcsb pdb:1U35|rcsb pdb:2V83|rcsb pdb:2W5Z|rcsb pdb:2WP1|rcsb pdb:2XL3|rcsb pdb:4EZH|rcsb pdb:5B1L|rcsb pdb:5B1M|reactome:R-MMU-427413|rcsb pdb:5IX1|reactome:R-MMU-5250924|rcsb pdb:5IX2|reactome:R-MMU-1266695|reactome:R-MMU-5578749|reactome:R-MMU-212300|reactome:R-MMU-5625886|reactome:R-MMU-2559580|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-983231|reactome:R-MMU-2559582|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214842|refseq:NP_038578.2|refseq:NP_659539.1|refseq:NP_835513.1|refseq:NP_835514.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:ood0OohxZHuhsWZtO7U7GMc+LwM10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:O35658	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-642072	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:c1qbp_mouse(display_long)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:GC1q-R protein(gene name synonym)|uniprotkb:C1qbp(gene name)|psi-mi:C1qbp(display_short)|uniprotkb:Gc1qbp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	reactome:R-MMU-140837|reactome:R-MMU-8980692|reactome:R-MMU-9013106|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|dip:DIP-32249N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:tPoLimqgF2SXeVXk7Z5rCQa+wTc10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q61656	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-643076|uniprotkb:E9Q105	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ddx5_mouse(display_long)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD1(gene name synonym)|uniprotkb:Ddx5(gene name)|psi-mi:Ddx5(display_short)|uniprotkb:Tnz2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|reactome:R-MMU-3899300|reactome:R-MMU-72163|reactome:R-MMU-9018519|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009299"(mRNA transcription)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|dip:DIP-32293N|mint:Q61656	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:X5OQN/Gdq852njTrHnlDliAjrQY10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q501J6	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-911206|uniprotkb:Q6P5G1|uniprotkb:Q8BIN2|ensembl:ENSMUSP00000155307	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ddx17_mouse(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:Ddx17(gene name)|psi-mi:Ddx17(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001035277.1|refseq:NP_951061.1|refseq:NP_951062.1|ensembl:ENSMUSG00000055065(gene)|ensembl:ENSMUST00000229877(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0061614"(miRNA transcription)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q501J6|reactome:R-MMU-3899300	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:uGXMsVmy7MWcTaJPNlkof05dS8I10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9CRT8	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-644629|uniprotkb:Q52KI1|ensembl:ENSMUSP00000043488	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:xpot_mouse(display_long)|uniprotkb:tRNA exportin(gene name synonym)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:Xpot(gene name)|psi-mi:Xpot(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000034667(gene)|ensembl:ENSMUST00000039810(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040017|mint:Q9CRT8	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:sxoS4tNMBaRRDwVJM5HlK1c2avE10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q6P5F9	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550236|ensembl:ENSMUSP00000020538|ensembl:ENSMUSP00000099933|ensembl:ENSMUSP00000099934|ensembl:ENSMUSP00000105178	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:xpo1_mouse(display_long)|uniprotkb:Xpo1(gene name)|psi-mi:Xpo1(display_short)|uniprotkb:Crm1(gene name synonym)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	rcsb pdb:3NC0|rcsb pdb:3NC1|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3769402|reactome:R-MMU-450520|reactome:R-MMU-5663220|reactome:R-MMU-5687128|reactome:R-MMU-68877|reactome:R-MMU-69273|reactome:R-MMU-9634638|reactome:R-MMU-9648025|reactome:R-MMU-9707616|rcsb pdb:3NBZ|ensembl:ENSMUSG00000020290(gene)|ensembl:ENSMUST00000020538(transcript)|ensembl:ENSMUST00000102869(transcript)|ensembl:ENSMUST00000102870(transcript)|ensembl:ENSMUST00000109551(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0042176"(regulation of protein catabolic process)|rcsb pdb:3GJX|rcsb pdb:3NBY|refseq:NP_001030303.1|refseq:NP_598775.2|refseq:XP_006514493.1|dip:DIP-48612N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:k02EX8YlQCgjt5EyEXvTFHQNPCI10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q62093	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550402|ensembl:ENSMUSP00000090059|ensembl:ENSMUSP00000120086|ensembl:ENSMUSP00000140016|uniprotkb:Q60701|uniprotkb:Q542L3	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:srsf2_mouse(display_long)|uniprotkb:Sfrs2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym)|uniprotkb:Srsf2(gene name)|psi-mi:Srsf2(display_short)|uniprotkb:Pr264(gene name synonym)|uniprotkb:Sfrs10(gene name synonym)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:Putative myelin regulatory factor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:XP_011247137.1|ensembl:ENSMUSG00000034120(gene)|ensembl:ENSMUST00000092404(transcript)|ensembl:ENSMUST00000136914(transcript)|ensembl:ENSMUST00000190993(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|interpro:IPR034893|interpro:IPR035979|mint:Q62093|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-72187|reactome:R-MMU-73856|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_035488.1|dip:DIP-44831N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:/LUrJ8xa42APUsgH5ke590Kxsh810090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P62320	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550316|ensembl:ENSMUSP00000020397|uniprotkb:P43331|uniprotkb:Q3TV81	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:smd3_mouse(display_long)|uniprotkb:Snrpd3(gene name)|psi-mi:Snrpd3(display_short)|uniprotkb:snRNP core protein D3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000020180(gene)|ensembl:ENSMUST00000020397(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005683"(U7 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|reactome:R-MMU-73856|reactome:R-MMU-77588|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:0071209"(U7 snRNA binding)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034099|mint:P62320|reactome:R-MMU-111367|reactome:R-MMU-191859|reactome:R-MMU-72163|reactome:R-MMU-72165|refseq:NP_080371.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:WkrSZVfVmSQrJYfy7mwp48xjsVA10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9EPL8	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550269|ensembl:ENSMUSP00000081782|uniprotkb:Q7TN09|uniprotkb:Q7TQ63|uniprotkb:Q8BKD8|uniprotkb:Q8BYI0	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ipo7_mouse(display_long)|uniprotkb:Ipo7(gene name)|psi-mi:Ipo7(display_short)|uniprotkb:Ranbp7(gene name synonym)|uniprotkb:Ran-binding protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000066232(gene)|ensembl:ENSMUST00000084731(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:Q9EPL8|refseq:NP_852658.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:YOGtbOzeE6Oq5T0J42GWW7fH9H010090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9CW03	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550068|ensembl:ENSMUSP00000025930|uniprotkb:O35667|uniprotkb:Q9QUS3	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:smc3_mouse(display_long)|uniprotkb:Smc3(gene name)|psi-mi:Smc3(display_short)|uniprotkb:Bam(gene name synonym)|uniprotkb:Bmh(gene name synonym)|uniprotkb:Cspg6(gene name synonym)|uniprotkb:Mmip1(gene name synonym)|uniprotkb:Smc3l1(gene name synonym)|uniprotkb:Smcd(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome segregation protein SmcD(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:Mad member-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000024974(gene)|ensembl:ENSMUST00000025930(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9CW03|rcsb pdb:2WD5|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_031816.2|dip:DIP-57028N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:9tJqVTJ2k3viYrJVtDfH2TekFIg10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P49718	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-913678|ensembl:ENSMUSP00000126135|ensembl:ENSMUSP00000148525|ensembl:ENSMUSP00000148648|uniprotkb:Q52KC3	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:mcm5_mouse(display_long)|uniprotkb:Mcm5(gene name)|psi-mi:Mcm5(display_short)|uniprotkb:Cdc46(gene name synonym)|uniprotkb:Mcmd5(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|ensembl:ENSMUSG00000005410(gene)|ensembl:ENSMUST00000164309(transcript)|ensembl:ENSMUST00000212426(transcript)|ensembl:ENSMUST00000212811(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|reactome:R-MMU-176187|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69052|dip:DIP-45875N|refseq:NP_001289469.1|refseq:NP_032592.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:/BtYm9P7ZJQbJh2+8Dre6uHX7Mc10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9ERU9	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-643756|uniprotkb:E9QM01|uniprotkb:Q61992|uniprotkb:Q8C9K9|ensembl:ENSMUSP00000003310	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rbp2_mouse(display_long)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Ranbp2(gene name)|psi-mi:Ranbp2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_035370.2|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000003226(gene)|ensembl:ENSMUST00000003310(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:Q9ERU9|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:cjIAIF0uuxSMRXErJiJc+OBJpAw10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P70168	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P97311	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-457132|uniprotkb:Q80YQ7|ensembl:ENSMUSP00000027601	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:mcm6_mouse(display_long)|uniprotkb:Mis5 homolog(gene name synonym)|uniprotkb:Mcm6(gene name)|psi-mi:Mcm6(display_short)|uniprotkb:Mcmd6(gene name synonym)|uniprotkb:Mis5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_032593.1|ensembl:ENSMUSG00000026355(gene)|ensembl:ENSMUST00000027601(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|interpro:IPR001208(MCM)|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|mint:P97311|reactome:R-MMU-176187|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:JwuQj25XyutAyROxAkOr/NyIjCA10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P14733	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-445247|uniprotkb:Q61791|ensembl:ENSMUSP00000025486	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:lmnb1_mouse(display_long)|uniprotkb:Lmnb1(gene name)|psi-mi:Lmnb1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_034851.2|mint:P14733|reactome:R-MMU-9035034|reactome:R-MMU-2559584|reactome:R-MMU-352238|reactome:R-MMU-4419969|reactome:R-MMU-9013405|ensembl:ENSMUSG00000024590(gene)|ensembl:ENSMUST00000025486(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:1904609"(cellular response to monosodium L-glutamate)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|go:"GO:0003690"(double-stranded DNA binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:/Mo4KS6v6KhDRlYgD5CVVVtWVD810090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P43247	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2549940|ensembl:ENSMUSP00000024967	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:msh2_mouse(display_long)|uniprotkb:Msh2(gene name)|psi-mi:Msh2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032142"(single guanine insertion binding)|go:"GO:0032143"(single thymine insertion binding)|go:"GO:0032181"(dinucleotide repeat insertion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|ensembl:ENSMUSG00000024151(gene)|ensembl:ENSMUST00000024967(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0006302"(double-strand break repair)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|reactome:R-MMU-5358565|reactome:R-MMU-5358606|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|refseq:NP_032654.1|dip:DIP-57027N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:rUJVRT7BabKPkMB4CSUAx5N9YbQ10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q6ZQ38	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-597255|uniprotkb:Q6PFR0|uniprotkb:Q9CV45|ensembl:ENSMUSP00000020315	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:cand1_mouse(display_long)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:Cand1(gene name)|psi-mi:Cand1(display_short)|uniprotkb:D10Ertd516e(gene name synonym)|uniprotkb:Kiaa0829(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_082270.1|ensembl:ENSMUSG00000020114(gene)|ensembl:ENSMUST00000020315(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039852|mint:Q6ZQ38|reactome:R-MMU-6798695|reactome:R-MMU-8951664|reactome:R-MMU-917937	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:E6bJujLfT/V3C8Iyk0hUD1m4gT010090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P97310	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-457049|uniprotkb:O08971|uniprotkb:O89057|uniprotkb:Q8C2R0|ensembl:ENSMUSP00000061923	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:mcm2_mouse(display_long)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:Mcm2(gene name)|psi-mi:Mcm2(display_short)|uniprotkb:Bm28(gene name synonym)|uniprotkb:Cdcl1(gene name synonym)|uniprotkb:Kiaa0030(gene name synonym)|uniprotkb:Mcmd2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_032590.2|dip:DIP-33057N|ensembl:ENSMUSG00000002870(gene)|ensembl:ENSMUST00000058011(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P97310|reactome:R-MMU-176187|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:HwAzfjnxpS94H12oI3OiiHTsEm410090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P69566	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-772305|uniprotkb:P84500|uniprotkb:Q3V136	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ranb9_mouse(display_long)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:B-cell antigen receptor Ig beta-associated protein 1(gene name synonym)|uniprotkb:Ranbp9(gene name)|psi-mi:Ranbp9(display_short)|uniprotkb:Ranbpm(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_064314.2|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|mint:P69566|interpro:IPR035782|interpro:IPR043136|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-MMU-373760|reactome:R-MMU-5673001|reactome:R-MMU-8851805	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:nKjsQ+KN8Z4mWEyQcRejUCLSDJY10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P54276	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2549976|uniprotkb:Q6GTK8|ensembl:ENSMUSP00000005503|uniprotkb:O54710	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:msh6_mouse(display_long)|uniprotkb:Msh6(gene name)|psi-mi:Msh6(display_short)|uniprotkb:Gtmbp(gene name synonym)|uniprotkb:MutS-alpha 160 kDa subunit(gene name synonym)|uniprotkb:G/T mismatch-binding protein(gene name synonym)|uniprotkb:MutS protein homolog 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000005370(gene)|ensembl:ENSMUST00000005503(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019899"(enzyme binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032142"(single guanine insertion binding)|go:"GO:0032143"(single thymine insertion binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR017261(DNA mismatch repair protein Msh6)|interpro:IPR027417|interpro:IPR036187|interpro:IPR036678|mint:P54276|reactome:R-MMU-5358565|refseq:NP_034960.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:vz2JuuX9XEhk1b4qWBrLcOJpbNo10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:A3KFM7	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550131|ensembl:ENSMUSP00000042291|uniprotkb:B9EKA7|uniprotkb:Q3UQS6|uniprotkb:Q80TE9	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:chd6_mouse(display_long)|uniprotkb:Chd6(gene name)|psi-mi:Chd6(display_short)|uniprotkb:ATP-dependent helicase CHD6(gene name synonym)|uniprotkb:Kiaa1335(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:XP_011238078.1|ensembl:ENSMUSG00000057133(gene)|ensembl:ENSMUST00000039782(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR038718|mint:A3KFM7|interpro:IPR000330(SNF2-related)|refseq:NP_775544.2|refseq:XP_017174747.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:bwFeRlosmKuYC0Jrg9zJZ6c28bg10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q61550	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550110|uniprotkb:Q3TQ09|uniprotkb:Q810A8|ensembl:ENSMUSP00000022927|uniprotkb:P70219|uniprotkb:Q91VB9|uniprotkb:Q9DBU4	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rad21_mouse(display_long)|uniprotkb:Rad21(gene name)|psi-mi:Rad21(display_short)|uniprotkb:Hr21(gene name synonym)|uniprotkb:Pokeweed agglutinin-binding protein 29(gene name synonym)|uniprotkb:SCC1 homolog(gene name synonym)|uniprotkb:Scc1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0008278"(cohesin complex)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016363"(nuclear matrix)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:Q61550|reactome:R-MMU-2467813|reactome:R-MMU-2468052|go:"GO:0003682"(chromatin binding)|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|ensembl:ENSMUSG00000022314(gene)|ensembl:ENSMUST00000022927(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|refseq:NP_033035.3|refseq:XP_006520707.1|refseq:XP_006520708.1|dip:DIP-56655N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:TXbWgmegqmBbcsQxxC4t7A/nc3o10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q62318	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:C0HKE1	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2527113|uniprotkb:P22752|uniprotkb:P10812|uniprotkb:Q149U0|uniprotkb:Q5SZZ2|ensembl:ENSMUSP00000077477|ensembl:ENSMUSP00000080088|ensembl:ENSMUSP00000088281|ensembl:ENSMUSP00000088285|ensembl:ENSMUSP00000089335|ensembl:ENSMUSP00000089339|ensembl:ENSMUSP00000089345|ensembl:ENSMUSP00000100034|ensembl:ENSMUSP00000127684	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:h2a1b_mouse(display_long)|uniprotkb:H2ac4(gene name)|psi-mi:H2ac4(display_short)|uniprotkb:Hist1h2ab(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000061615(gene)|ensembl:ENSMUSG00000069270(gene)|ensembl:ENSMUSG00000069272(gene)|ensembl:ENSMUSG00000069301(gene)|ensembl:ENSMUSG00000069309(gene)|ensembl:ENSMUSG00000071478(gene)|ensembl:ENSMUSG00000071516(gene)|ensembl:ENSMUSG00000094248(gene)|ensembl:ENSMUSG00000094777(gene)|ensembl:ENSMUST00000070124(transcript)|ensembl:ENSMUST00000078369(transcript)|ensembl:ENSMUST00000081342(transcript)|ensembl:ENSMUST00000090776(transcript)|ensembl:ENSMUST00000091741(transcript)|ensembl:ENSMUST00000091751(transcript)|ensembl:ENSMUST00000102969(transcript)|ensembl:ENSMUST00000171127(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:C0HKE1|rcsb pdb:5B1L|rcsb pdb:5B1M|rcsb pdb:5XM0|rcsb pdb:5XM1|ensembl:ENSMUST00000091745(transcript)|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-3214815|reactome:R-MMU-3214858|reactome:R-MMU-427359|reactome:R-MMU-427413|reactome:R-MMU-5250924|reactome:R-MMU-5578749|reactome:R-MMU-5625886|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-5689901|reactome:R-MMU-606279|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|reactome:R-MMU-212300|refseq:NP_001171015.1|refseq:NP_783591.2|refseq:NP_835489.1|refseq:NP_835491.1|refseq:NP_835492.1|refseq:NP_835493.1|refseq:NP_835494.1|refseq:NP_835495.1|refseq:NP_835496.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:4Qno1mMYZB6FdNoojrzulWLVq8410090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P08775	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2549849|ensembl:ENSMUSP00000050771|uniprotkb:Q5F298	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rpb1_mouse(display_long)|uniprotkb:Polr2a(gene name)|psi-mi:Polr2a(display_short)|uniprotkb:Rpii215(gene name synonym)|uniprotkb:Rpo2-1(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000005198(gene)|ensembl:ENSMUST00000058470(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:0071453"(cellular response to oxygen levels)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|mint:P08775|reactome:R-MMU-113418|reactome:R-MMU-5578749|reactome:R-MMU-674695|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6796648|reactome:R-MMU-6803529|reactome:R-MMU-6807505|reactome:R-MMU-72086|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-72203|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-75955|reactome:R-MMU-76042|reactome:R-MMU-77075|reactome:R-MMU-9018519|reactome:R-MMU-112382|refseq:NP_001277997.1|dip:DIP-46369N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:kUX/HdU6Y2VHAGjySBcOxfS08XA10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9WTM5	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2549911|ensembl:ENSMUSP00000103400|ensembl:ENSMUSP00000147502	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:ruvb2_mouse(display_long)|uniprotkb:Ruvbl2(gene name)|psi-mi:Ruvbl2(display_short)|uniprotkb:p47 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000003868(gene)|ensembl:ENSMUST00000107771(transcript)|ensembl:ENSMUST00000211214(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051117"(ATPase binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9WTM5|go:"GO:0140603"(obsolete ATP hydrolysis activity)|refseq:NP_035434.1|refseq:XP_006540785.1|refseq:XP_006540786.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:tHnjngaz5qWy9sPXagFLp3TRDtA10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P97313	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2272005|uniprotkb:E9QN15|uniprotkb:O88187|uniprotkb:P97928|uniprotkb:Q307W9|uniprotkb:Q3V2W8|uniprotkb:Q8C2A7|uniprotkb:Q9Z341|ensembl:ENSMUSP00000023352	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:prkdc_mouse(display_long)|uniprotkb:Prkdc(gene name)|psi-mi:Prkdc(display_short)|uniprotkb:Xrcc7(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_035289.2|ensembl:ENSMUSG00000022672(gene)|ensembl:ENSMUST00000023352(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002684"(positive regulation of immune system process)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1905221"(positive regulation of platelet formation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P97313|reactome:R-MMU-5693571|reactome:R-MMU-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:CE0UDetYkRmQdIxj+xDjU3hYpzo10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P11103	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-642213|uniprotkb:Q9JLX4|uniprotkb:Q9QVQ3	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:parp1_mouse(display_long)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Parp1(gene name)|psi-mi:Parp1(display_short)|uniprotkb:Adprp(gene name synonym)|uniprotkb:Adprt(gene name synonym)|uniprotkb:Adprt1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|reactome:R-MMU-110362|reactome:R-MMU-2173795|reactome:R-MMU-3108214|reactome:R-MMU-5685939|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0034644"(cellular response to UV)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071451"(cellular response to superoxide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903516"(regulation of single strand break repair)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1903827"|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:0070212"(protein poly-ADP-ribosylation)|mint:P11103|dip:DIP-39371N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:ZJY1aTtD8Cz198SVs9FDdUSli7s10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q01320	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-642809|uniprotkb:E9PX08|ensembl:ENSMUSP00000068896	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:top2a_mouse(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:Top2a(gene name)|psi-mi:Top2a(display_short)|uniprotkb:Top2(gene name synonym)|uniprotkb:Top-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:XP_006533216.1|refseq:NP_035753.2|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:Q01320|reactome:R-MMU-4615885|interpro:IPR020568|ensembl:ENSMUSG00000020914(gene)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030261"(chromosome condensation)|ensembl:ENSMUST00000068031(transcript)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:0051309"(female meiosis chromosome separation)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|go:"GO:0030263"(apoptotic chromosome condensation)|dip:DIP-40621N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:4bT7YxXbxkbqULDvXoFRreoX9Gs10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q920B9	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2549823|uniprotkb:Q3TZ48|uniprotkb:Q3UFH0|uniprotkb:Q921H4	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:sp16h_mouse(display_long)|uniprotkb:Supt16h(gene name)|psi-mi:Supt16h(display_short)|uniprotkb:Fact140(gene name synonym)|uniprotkb:Factp140(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex subunit SPT16(gene name synonym)|uniprotkb:FACT 140 kDa subunit(gene name synonym)|uniprotkb:FACTp140(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 140 kDa subunit(gene name synonym)|uniprotkb:Supt16(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034724"(DNA replication-independent chromatin organization)|go:"GO:0035101"(FACT complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR029149|interpro:IPR033825|interpro:IPR036005|interpro:IPR040258|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-6796648|interpro:IPR029148|reactome:R-MMU-6804756|reactome:R-MMU-75955|interpro:IPR013953(FACT complex subunit Spt16p/Cdc68p)|refseq:NP_291096.2|dip:DIP-55972N|mint:Q920B9	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:qcl0ckY0w3tIem/ezLyPtHVUnZA10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q8CFI7	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2549877|ensembl:ENSMUSP00000031167	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:rpb2_mouse(display_long)|uniprotkb:Polr2b(gene name)|psi-mi:Polr2b(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit B(gene name synonym)|uniprotkb:RNA polymerase II subunit B2(gene name synonym)|uniprotkb:RNA polymerase II subunit 2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 140 kDa polypeptide(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000029250(gene)|ensembl:ENSMUST00000031167(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR007646(RNA polymerase Rpb2, domain 4)|interpro:IPR007647(RNA polymerase Rpb2, domain 5)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR037033|interpro:IPR037034|mint:Q8CFI7|reactome:R-MMU-112382|reactome:R-MMU-113418|reactome:R-MMU-5578749|reactome:R-MMU-674695|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6796648|reactome:R-MMU-6803529|reactome:R-MMU-6807505|reactome:R-MMU-72086|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-72203|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-75955|reactome:R-MMU-76042|reactome:R-MMU-77075|reactome:R-MMU-9018519|refseq:NP_722493.2|dip:DIP-57023N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:Tmvj+m8fdVI+HHVma1Y0WYCSl4c10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:P17918	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-1173716|ensembl:ENSMUSP00000028817	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:pcna_mouse(display_long)|uniprotkb:Pcna(gene name)|psi-mi:Pcna(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0033993"(response to lipid)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P17918|reactome:R-MMU-110312|go:"GO:0035035"(histone acetyltransferase binding)|reactome:R-MMU-110314|reactome:R-MMU-110320|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174437|reactome:R-MMU-4615885|reactome:R-MMU-5358565|reactome:R-MMU-5651801|reactome:R-MMU-5655862|reactome:R-MMU-5656121|reactome:R-MMU-5656169|reactome:R-MMU-5685942|reactome:R-MMU-5696397|reactome:R-MMU-5696400|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6804114|reactome:R-MMU-69091|ensembl:ENSMUSG00000027342(gene)|ensembl:ENSMUST00000028817(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|refseq:NP_035175.1|reactome:R-MMU-69166|reactome:R-MMU-69183|reactome:R-MMU-8866654|dip:DIP-39409N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:AREQR8Nveu4uamAlZuOEwlnDDec10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q99MD9	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-913410|uniprotkb:O35499|uniprotkb:O88993|uniprotkb:Q3V150|uniprotkb:Q99KE9	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:nasp_mouse(display_long)|uniprotkb:Nasp(gene name)|psi-mi:Nasp(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	refseq:NP_001271158.1|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001074944.1|interpro:IPR019544|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q99MD9	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:kdLcXZo8FtCJsQJTD5bAIXInfsk10090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q64525	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550168|ensembl:ENSMUSP00000135427	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:h2b2b_mouse(display_long)|uniprotkb:Hist2h2bb(gene name)|psi-mi:Hist2h2bb(display_short)|uniprotkb:H2b 616(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000105827(gene)|ensembl:ENSMUST00000177113(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-212300|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-3214815|reactome:R-MMU-427359|reactome:R-MMU-427413|reactome:R-MMU-5250924|reactome:R-MMU-5578749|reactome:R-MMU-5625886|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-606279|reactome:R-MMU-69473|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8866654|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|reactome:R-MMU-3214847|refseq:NP_783597.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:Pr400UVIaD7O446lc9vZeStUKn010090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q9Z0E3	uniprotkb:Q9CU62	intact:EBI-80858|uniprotkb:Q9JLW4|uniprotkb:Q9JLW5|uniprotkb:Q9JLW6|uniprotkb:Q9JLW7|uniprotkb:Q9JLW8|uniprotkb:Q9JLW9|uniprotkb:Q9JLX0|uniprotkb:Q9JLW0|uniprotkb:Q9JLW1|uniprotkb:Q9JLW2|uniprotkb:Q9JLW3|ensembl:ENSMUSP00000114904	intact:EBI-2550016|uniprotkb:A2AFQ5|ensembl:ENSMUSP00000044645|uniprotkb:Q3V480|uniprotkb:Q9CUX9|uniprotkb:Q9D959|uniprotkb:Q9WTU1	psi-mi:aire_mouse(display_long)|uniprotkb:Aire(gene name)|psi-mi:Aire(display_short)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog(gene name synonym)	psi-mi:smc1a_mouse(display_long)|uniprotkb:Smc1a(gene name)|psi-mi:Smc1a(display_short)|uniprotkb:Smc1(gene name synonym)|uniprotkb:Smc1l1(gene name synonym)|uniprotkb:Smcb(gene name synonym)|uniprotkb:Sb1.8(gene name synonym)|uniprotkb:Chromosome segregation protein SmcB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2549816|imex:IM-13587-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0042393"(histone binding)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006959"(humoral immune response)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|ensembl:ENSMUSG00000000731(gene)|ensembl:ENSMUST00000128241(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_001258478.1|refseq:NP_001258479.1|refseq:NP_001258480.1|refseq:NP_001258481.1|refseq:NP_001258482.1|refseq:NP_001258483.1|refseq:NP_001258484.1|refseq:NP_001258485.1|refseq:NP_001258486.1|refseq:NP_001258487.1|refseq:NP_001258488.1|refseq:NP_033776.1|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|ensembl:ENSMUSG00000000731|dip:DIP-31030N	ensembl:ENSMUSG00000041133(gene)|ensembl:ENSMUST00000045312(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|go:"GO:0008278"(cohesin complex)|interpro:IPR036277|mint:Q9CU62|rcsb pdb:2WD5|reactome:R-MMU-2467813|interpro:IPR029683|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_062684.2|dip:DIP-57021N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-1c6)|taxid:10090(Mouse 1C6 hybridoma B-cells)	-	2010/01/27	2019/05/28	rogid:dt9bHsdXRvL1aXj1QhALTzlsl8s10090	rogid:3TtjC4Y8krgvnUafgy2DG2XTnH810090	intact-crc:D852227F506F63BB|rigid:grv7Y/CJfaZ1TWPyQgq2A8OHP4I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:O43918	uniprotkb:P78527	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550545|imex:IM-13587-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:CEFB1285443A039C|rigid:O/ahsl4fDLSeaHX6x33LQBwO3FQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N1F7	uniprotkb:O43918	intact:EBI-1042703|uniprotkb:Q14705|uniprotkb:B3KPQ8|ensembl:ENSP00000310668	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:nup93_human(display_long)|uniprotkb:NUP93(gene name)|psi-mi:NUP93(display_short)|uniprotkb:KIAA0095(gene name synonym)|uniprotkb:Nucleoporin Nup93(gene name synonym)|uniprotkb:93 kDa nucleoporin(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550555|imex:IM-13587-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055484.3|refseq:NP_001229724.1|refseq:NP_001229725.1|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR007231(Nucleoporin interacting component)|mint:Q8N1F7|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|ensembl:ENSG00000102900(gene)|reactome:R-HSA-168271|ensembl:ENST00000308159(transcript)|go:"GO:0005635"(nuclear envelope)|reactome:R-HSA-168276|go:"GO:0005643"(nuclear pore)|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-191859|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005256320.1|dip:DIP-44020N	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:pkk5pooUC4yQShpqjiwNLddfy149606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:791AFECD9DC56CE3|rigid:N8/GEOklzBjvlKUX+iP3nwBjtGw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43918	uniprotkb:P17844	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550560|imex:IM-13587-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	intact-crc:7101EC467E4778B7|rigid:KBH7GC83an8RHtlJBM8rsnVbPpI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01130	uniprotkb:O43918	intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550572|imex:IM-13587-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:6C10E1266FA8BDE6|rigid:3mVt3U+RKANm7n5mgoXxLXAT/8g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43918	uniprotkb:Q13263	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550605|imex:IM-13587-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	intact-crc:F9A74DC55C77C341|rigid:AyaFqRJOU75WzYBW6rh7yiQ9z8Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16104	uniprotkb:P13010	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550624|imex:IM-13587-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:73AE990CC587BB73|rigid:JyYaIqj/KVJB9pD/loIg/lMe+2w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16104	uniprotkb:P11388	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550624|imex:IM-13587-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	intact-crc:73AE990CC587BB73|rigid:JyYaIqj/KVJB9pD/loIg/lMe+2w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16104	uniprotkb:O43918	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550624|imex:IM-13587-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:73AE990CC587BB73|rigid:JyYaIqj/KVJB9pD/loIg/lMe+2w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16104	uniprotkb:P09874	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550624|imex:IM-13587-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:73AE990CC587BB73|rigid:JyYaIqj/KVJB9pD/loIg/lMe+2w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16104	uniprotkb:P78527	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550624|imex:IM-13587-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:73AE990CC587BB73|rigid:JyYaIqj/KVJB9pD/loIg/lMe+2w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09874	uniprotkb:P78527	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550632|imex:IM-13587-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|comment:"Only trace amounts of XRCC5 (Ku-86) and PRKDC were observed."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:8CC09545EBBF4CDF|rigid:HBi+g9wEo9LUKkxxKUA/5v97XfI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09874	uniprotkb:P13010	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550632|imex:IM-13587-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|comment:"Only trace amounts of XRCC5 (Ku-86) and PRKDC were observed."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:8CC09545EBBF4CDF|rigid:HBi+g9wEo9LUKkxxKUA/5v97XfI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09874	uniprotkb:P11388	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550632|imex:IM-13587-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|comment:"Only trace amounts of XRCC5 (Ku-86) and PRKDC were observed."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	intact-crc:8CC09545EBBF4CDF|rigid:HBi+g9wEo9LUKkxxKUA/5v97XfI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13010	uniprotkb:P11388	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550640|imex:IM-13587-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	intact-crc:16D8031E70675F31|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13010	uniprotkb:P78527	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550640|imex:IM-13587-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:16D8031E70675F31|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13010	uniprotkb:P09874	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550640|imex:IM-13587-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:16D8031E70675F31|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13010	uniprotkb:O43918	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550640|imex:IM-13587-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:16D8031E70675F31|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78527	uniprotkb:P09874	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550648|imex:IM-13587-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:C7EC315A4B776D12|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78527	uniprotkb:O43918	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550648|imex:IM-13587-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:C7EC315A4B776D12|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78527	uniprotkb:P11388	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550648|imex:IM-13587-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	intact-crc:C7EC315A4B776D12|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P78527	uniprotkb:P13010	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2550648|imex:IM-13587-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:C7EC315A4B776D12|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11388	uniprotkb:P78527	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2568821|imex:IM-13587-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606	intact-crc:FC1651D45E32BBD5|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11388	uniprotkb:O43918	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2568821|imex:IM-13587-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:FC1651D45E32BBD5|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11388	uniprotkb:P13010	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2568821|imex:IM-13587-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:FC1651D45E32BBD5|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11388	uniprotkb:P09874	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2568821|imex:IM-13587-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|caution:"The participant EBI-1753081(O43918) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:FC1651D45E32BBD5|rigid:BcqBjVWEu380/8GPoIdUWMhM/6c	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43918	uniprotkb:P20700	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	intact:EBI-968218|ensembl:ENSP00000261366|uniprotkb:Q3SYN7|uniprotkb:Q96EI6|uniprotkb:B2R6J6	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:lmnb1_human(display_long)|uniprotkb:LMNB1(gene name)|psi-mi:LMNB1(display_short)|uniprotkb:LMN2(gene name synonym)|uniprotkb:LMNB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2571569|imex:IM-13587-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	ensembl:ENSG00000113368(gene)|ensembl:ENST00000261366(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P20700|rcsb pdb:2KPW|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3JT0|rcsb pdb:3TYY|rcsb pdb:3UMN|rcsb pdb:5VVX|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|reactome:R-HSA-2559584|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-4419969|reactome:R-HSA-8862803|reactome:R-HSA-8950505|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:NP_005564.1|dip:DIP-34897N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rogid:ZLv4OS5VSmn3sdXB9IP98YdQ+Iw9606	intact-crc:ED98D07C7A147CAC|rigid:ejQOPS7XL3MGUmqPk5ONE7PKt2c	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43918	uniprotkb:Q99MD9	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	intact:EBI-913410|uniprotkb:O35499|uniprotkb:O88993|uniprotkb:Q3V150|uniprotkb:Q99KE9	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:nasp_mouse(display_long)|uniprotkb:Nasp(gene name)|psi-mi:Nasp(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2571787|imex:IM-13587-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	refseq:NP_001271158.1|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001074944.1|interpro:IPR019544|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q99MD9	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rogid:kdLcXZo8FtCJsQJTD5bAIXInfsk10090	intact-crc:6B1EFA31CA16E5E6|rigid:HMotFxWffPlFQ3kSCXJeKv6iihg	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7TPV4	uniprotkb:O43918	intact:EBI-1373622|uniprotkb:O35851|uniprotkb:Q80Y66|uniprotkb:Q8R4X2|uniprotkb:Q99KP0|ensembl:ENSMUSP00000044827	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:mbb1a_mouse(display_long)|uniprotkb:Mybbp1a(gene name)|psi-mi:Mybbp1a(display_short)|uniprotkb:P160(gene name synonym)|uniprotkb:Myb-binding protein of 160 kDa(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2571822|imex:IM-13587-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058056.2|dip:DIP-39831N|ensembl:ENSMUSG00000040463(gene)|ensembl:ENSMUST00000045633(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR016024(Armadillo-type fold)|mint:Q7TPV4|reactome:R-MMU-5250924	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:rt1TQLZB7JNBkpt3DooDAlzOYCo10090	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:0FC0D941D94B542E|rigid:LwuCetkChiOsMYfpRB7mzCvRI7A	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60216	uniprotkb:O43918	intact:EBI-80739|ensembl:ENSP00000297338|uniprotkb:Q15001|uniprotkb:Q99568|uniprotkb:A8K0E0	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:rad21_human(display_long)|uniprotkb:RAD21(gene name)|psi-mi:RAD21(display_short)|uniprotkb:HR21(gene name synonym)|uniprotkb:KIAA0078(gene name synonym)|uniprotkb:Nuclear matrix protein 1(gene name synonym)|uniprotkb:SCC1 homolog(gene name synonym)|uniprotkb:NXP1(gene name synonym)|uniprotkb:SCC1(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abramson et al. (2010)	imex:IM-13587|pubmed:20085707	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2571848|imex:IM-13587-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164754(gene)|ensembl:ENST00000297338(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008278"(cohesin complex)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O60216|rcsb pdb:4PJU|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|rcsb pdb:4PJW|rcsb pdb:4PK7|rcsb pdb:6QNX|rcsb pdb:6RRC|reactome:R-HSA-2468052|rcsb pdb:6RRK|reactome:R-HSA-2470946|rcsb pdb:6WG3|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|refseq:NP_006256.1|dip:DIP-29201N	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/27	2014/10/16	rogid:9H+Fipb91zQo7ie3YHCL7Ardveo9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:9294056DFC904E6E|rigid:DP2UGN4wOG4aJ6Bcq8CVgNKW4zs	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)