#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q921E6-2	uniprotkb:Q91VJ4	intact:EBI-1896016	intact:EBI-2527046|ensembl:ENSMUSP00000009138|ensembl:ENSMUSP00000113657|ensembl:ENSMUSP00000156711	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:stk38_mouse(display_long)|uniprotkb:Stk38(gene name)|psi-mi:Stk38(display_short)|uniprotkb:Ndr1(gene name synonym)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531516|imex:IM-12118-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q91VJ4|reactome:R-MMU-9013418|reactome:R-MMU-9013422|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSMUSG00000024006(gene)|ensembl:ENSMUST00000009138(transcript)|ensembl:ENSMUST00000119274(transcript)|ensembl:ENSMUST00000232836(transcript)|refseq:NP_598876.1	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:TvwVb4eUVw+H1smxX4+Z3LjcAUw10090	intact-crc:1BFF7318AE5DD952|rigid:LtxTjRmd9naf1Z/dcKrL2VSBxKs	false	flag tag:?-?|biotin tag:?-?	identified peptide:181-211|identified peptide:212-223	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:P70351	intact:EBI-1896016	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531516|imex:IM-12118-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	intact-crc:1BFF7318AE5DD952|rigid:LtxTjRmd9naf1Z/dcKrL2VSBxKs	false	flag tag:?-?|biotin tag:?-?	identified peptide:40-48|identified peptide:53-62|identified peptide:385-406|identified peptide:467-474|sufficient binding region:481-492|identified peptide:729-742	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q60973	intact:EBI-1896016	intact:EBI-302297|ensembl:ENSMUSP00000033720|uniprotkb:Q3UX20|uniprotkb:A2AFJ0	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:rbbp7_mouse(display_long)|uniprotkb:Rbbp7(gene name)|psi-mi:Rbbp7(display_short)|uniprotkb:Rbap46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531516|imex:IM-12118-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60973|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8951664|reactome:R-MMU-8953750|ensembl:ENSMUSG00000031353(gene)|ensembl:ENSMUST00000033720(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006338"(chromatin remodeling)|refseq:NP_033057.3|dip:DIP-32856N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:+OV9hWS13A8fAypZJAXf656Z25U10090	intact-crc:1BFF7318AE5DD952|rigid:LtxTjRmd9naf1Z/dcKrL2VSBxKs	false	flag tag:?-?|biotin tag:?-?	identified peptide:5-14|identified peptide:131-142|identified peptide:349-375	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q02395	intact:EBI-1896016	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531516|imex:IM-12118-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	intact-crc:1BFF7318AE5DD952|rigid:LtxTjRmd9naf1Z/dcKrL2VSBxKs	false	flag tag:?-?|biotin tag:?-?	identified peptide:417-424|identified peptide:488-497|identified peptide:550-561	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q62315	intact:EBI-1896016	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531516|imex:IM-12118-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:1BFF7318AE5DD952|rigid:LtxTjRmd9naf1Z/dcKrL2VSBxKs	false	flag tag:?-?|biotin tag:?-?	identified peptide:132-149|identified peptide:15-27|identified peptide:58-69	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q9Z248	intact:EBI-1896016	intact:EBI-2526952|uniprotkb:Q6PF91|uniprotkb:Q78HB0|uniprotkb:Q8BGV1|uniprotkb:Q8CE51|ensembl:ENSMUSP00000092993	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:aebp2_mouse(display_long)|uniprotkb:Aebp2(gene name)|psi-mi:Aebp2(display_short)|uniprotkb:Adipocyte enhancer-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531516|imex:IM-12118-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000030232(gene)|ensembl:ENSMUST00000095350(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-212300|reactome:R-MMU-3214841|refseq:NP_001005605.1|refseq:NP_001296365.1|refseq:NP_001296366.1|refseq:NP_033767.2|refseq:NP_848918.1|refseq:XP_006506969.1|refseq:XP_006506972.1	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:/WahLrADSj075nV+/m/6Up+FaoI10090	intact-crc:1BFF7318AE5DD952|rigid:LtxTjRmd9naf1Z/dcKrL2VSBxKs	false	flag tag:?-?|biotin tag:?-?	identified peptide:297-310|identified peptide:383-400|identified peptide:476-487	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q61188	intact:EBI-1896016	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531516|imex:IM-12118-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:1BFF7318AE5DD952|rigid:LtxTjRmd9naf1Z/dcKrL2VSBxKs	false	flag tag:?-?|biotin tag:?-?	sufficient binding region:53-61|identified peptide:65-78|identified peptide:420-441|identified peptide:715-727	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q60972	intact:EBI-1896016	intact:EBI-302291|uniprotkb:A2A875|ensembl:ENSMUSP00000099658	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:rbbp4_mouse(display_long)|uniprotkb:Rbbp4(gene name)|psi-mi:Rbbp4(display_short)|uniprotkb:Rbap48(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531516|imex:IM-12118-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000057236(gene)|ensembl:ENSMUST00000102598(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60972|reactome:R-MMU-1538133|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8953750|refseq:NP_033056.2|dip:DIP-32855N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I10090	intact-crc:1BFF7318AE5DD952|rigid:LtxTjRmd9naf1Z/dcKrL2VSBxKs	false	flag tag:?-?|biotin tag:?-?	identified peptide:144-156|identified peptide:252-258|identified peptide:297-304|identified peptide:341-350	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q80U70	intact:EBI-1896016	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531516|imex:IM-12118-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:1BFF7318AE5DD952|rigid:LtxTjRmd9naf1Z/dcKrL2VSBxKs	false	flag tag:?-?|biotin tag:?-?	identified peptide:106-115|identified peptide:6-40|identified peptide:133-142|identified peptide:249-255|identified peptide:296-306|identified peptide:345-362|identified peptide:406-415|identified peptide:540-557|sufficient binding region:598-613|identified peptide:723-734	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q62315	intact:EBI-1896016	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531927|imex:IM-12118-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:EE65D842C3A78E80|rigid:qj1gnzFd1FbuPbI19NkduMaXB5g	false	flag tag:?-?|biotin tag:?-?	identified peptide:15-27|identified peptide:58-69|identified peptide:132-149	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q80U70	intact:EBI-1896016	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531927|imex:IM-12118-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:EE65D842C3A78E80|rigid:qj1gnzFd1FbuPbI19NkduMaXB5g	false	flag tag:?-?|biotin tag:?-?	identified peptide:106-115|identified peptide:6-40|identified peptide:133-142|identified peptide:249-255|identified peptide:296-306|identified peptide:345-362|identified peptide:406-415|identified peptide:540-557|sufficient binding region:598-613|identified peptide:723-734	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q61188	intact:EBI-1896016	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531927|imex:IM-12118-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:EE65D842C3A78E80|rigid:qj1gnzFd1FbuPbI19NkduMaXB5g	false	flag tag:?-?|biotin tag:?-?	sufficient binding region:53-61|identified peptide:65-78|identified peptide:420-441|identified peptide:715-727	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:P70351	intact:EBI-1896016	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531927|imex:IM-12118-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	intact-crc:EE65D842C3A78E80|rigid:qj1gnzFd1FbuPbI19NkduMaXB5g	false	flag tag:?-?|biotin tag:?-?	identified peptide:40-48|identified peptide:53-62|identified peptide:385-406|identified peptide:467-474|sufficient binding region:481-492|identified peptide:729-742	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q02395	intact:EBI-1896016	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531927|imex:IM-12118-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	intact-crc:EE65D842C3A78E80|rigid:qj1gnzFd1FbuPbI19NkduMaXB5g	false	flag tag:?-?|biotin tag:?-?	identified peptide:417-424|identified peptide:488-497|identified peptide:550-561	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q9Z248	intact:EBI-1896016	intact:EBI-2526952|uniprotkb:Q6PF91|uniprotkb:Q78HB0|uniprotkb:Q8BGV1|uniprotkb:Q8CE51|ensembl:ENSMUSP00000092993	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:aebp2_mouse(display_long)|uniprotkb:Aebp2(gene name)|psi-mi:Aebp2(display_short)|uniprotkb:Adipocyte enhancer-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531927|imex:IM-12118-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000030232(gene)|ensembl:ENSMUST00000095350(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-212300|reactome:R-MMU-3214841|refseq:NP_001005605.1|refseq:NP_001296365.1|refseq:NP_001296366.1|refseq:NP_033767.2|refseq:NP_848918.1|refseq:XP_006506969.1|refseq:XP_006506972.1	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:/WahLrADSj075nV+/m/6Up+FaoI10090	intact-crc:EE65D842C3A78E80|rigid:qj1gnzFd1FbuPbI19NkduMaXB5g	false	flag tag:?-?|biotin tag:?-?	identified peptide:297-310|identified peptide:383-400|identified peptide:476-487	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q60972	intact:EBI-1896016	intact:EBI-302291|uniprotkb:A2A875|ensembl:ENSMUSP00000099658	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:rbbp4_mouse(display_long)|uniprotkb:Rbbp4(gene name)|psi-mi:Rbbp4(display_short)|uniprotkb:Rbap48(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531927|imex:IM-12118-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000057236(gene)|ensembl:ENSMUST00000102598(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60972|reactome:R-MMU-1538133|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8953750|refseq:NP_033056.2|dip:DIP-32855N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I10090	intact-crc:EE65D842C3A78E80|rigid:qj1gnzFd1FbuPbI19NkduMaXB5g	false	flag tag:?-?|biotin tag:?-?	identified peptide:144-156|identified peptide:252-258|identified peptide:297-304|identified peptide:341-350	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-2	uniprotkb:Q60973	intact:EBI-1896016	intact:EBI-302297|ensembl:ENSMUSP00000033720|uniprotkb:Q3UX20|uniprotkb:A2AFJ0	psi-mi:q921e6-2(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-1(isoform synonym)	psi-mi:rbbp7_mouse(display_long)|uniprotkb:Rbbp7(gene name)|psi-mi:Rbbp7(display_short)|uniprotkb:Rbap46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2531927|imex:IM-12118-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60973|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8951664|reactome:R-MMU-8953750|ensembl:ENSMUSG00000031353(gene)|ensembl:ENSMUST00000033720(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006338"(chromatin remodeling)|refseq:NP_033057.3|dip:DIP-32856N	psi-mi:"MI:0469"(intact)	isoform-comment:"Translation initiates from a non-canonical start codon (GUG)."	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:IbHwnx5vx3XBED9ff0mCV4+kDCU10090	rogid:+OV9hWS13A8fAypZJAXf656Z25U10090	intact-crc:EE65D842C3A78E80|rigid:qj1gnzFd1FbuPbI19NkduMaXB5g	false	flag tag:?-?|biotin tag:?-?	identified peptide:131-142|identified peptide:5-14|identified peptide:349-375	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:Q60972	intact:EBI-1896020	intact:EBI-302291|uniprotkb:A2A875|ensembl:ENSMUSP00000099658	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:rbbp4_mouse(display_long)|uniprotkb:Rbbp4(gene name)|psi-mi:Rbbp4(display_short)|uniprotkb:Rbap48(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000057236(gene)|ensembl:ENSMUST00000102598(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60972|reactome:R-MMU-1538133|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8953750|refseq:NP_033056.2|dip:DIP-32855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I10090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:144-156|identified peptide:252-258|identified peptide:297-304|identified peptide:341-350	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:Q60973	intact:EBI-1896020	intact:EBI-302297|ensembl:ENSMUSP00000033720|uniprotkb:Q3UX20|uniprotkb:A2AFJ0	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:rbbp7_mouse(display_long)|uniprotkb:Rbbp7(gene name)|psi-mi:Rbbp7(display_short)|uniprotkb:Rbap46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60973|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8951664|reactome:R-MMU-8953750|ensembl:ENSMUSG00000031353(gene)|ensembl:ENSMUST00000033720(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006338"(chromatin remodeling)|refseq:NP_033057.3|dip:DIP-32856N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:+OV9hWS13A8fAypZJAXf656Z25U10090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:5-14|identified peptide:131-142|identified peptide:349-375	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:Q61188	intact:EBI-1896020	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	sufficient binding region:53-61|identified peptide:65-78|identified peptide:420-441|identified peptide:715-727	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:Q02395	intact:EBI-1896020	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:417-424|identified peptide:488-497|identified peptide:550-561	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:Q9Z248	intact:EBI-1896020	intact:EBI-2526952|uniprotkb:Q6PF91|uniprotkb:Q78HB0|uniprotkb:Q8BGV1|uniprotkb:Q8CE51|ensembl:ENSMUSP00000092993	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:aebp2_mouse(display_long)|uniprotkb:Aebp2(gene name)|psi-mi:Aebp2(display_short)|uniprotkb:Adipocyte enhancer-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000030232(gene)|ensembl:ENSMUST00000095350(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-212300|reactome:R-MMU-3214841|refseq:NP_001005605.1|refseq:NP_001296365.1|refseq:NP_001296366.1|refseq:NP_033767.2|refseq:NP_848918.1|refseq:XP_006506969.1|refseq:XP_006506972.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:/WahLrADSj075nV+/m/6Up+FaoI10090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:297-310|identified peptide:383-400|identified peptide:476-487	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:Q91VJ4	intact:EBI-1896020	intact:EBI-2527046|ensembl:ENSMUSP00000009138|ensembl:ENSMUSP00000113657|ensembl:ENSMUSP00000156711	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:stk38_mouse(display_long)|uniprotkb:Stk38(gene name)|psi-mi:Stk38(display_short)|uniprotkb:Ndr1(gene name synonym)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q91VJ4|reactome:R-MMU-9013418|reactome:R-MMU-9013422|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSMUSG00000024006(gene)|ensembl:ENSMUST00000009138(transcript)|ensembl:ENSMUST00000119274(transcript)|ensembl:ENSMUST00000232836(transcript)|refseq:NP_598876.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:TvwVb4eUVw+H1smxX4+Z3LjcAUw10090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:181-211|identified peptide:212-223	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:Q62315	intact:EBI-1896020	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:132-149|identified peptide:15-27|identified peptide:58-69	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:P70351	intact:EBI-1896020	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:40-48|identified peptide:53-62|identified peptide:385-406|identified peptide:467-474|sufficient binding region:481-492|identified peptide:729-742	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:Q80U70	intact:EBI-1896020	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:106-115|identified peptide:6-40|identified peptide:133-142|identified peptide:249-255|identified peptide:296-306|identified peptide:345-362|identified peptide:406-415|identified peptide:540-557|sufficient binding region:598-613|identified peptide:723-734	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:A2AKX3	intact:EBI-1896020	intact:EBI-2532140|uniprotkb:A2AKX4|uniprotkb:A2AR33|uniprotkb:Q6IMG6|uniprotkb:Q6PED8|uniprotkb:Q6ZQ81|uniprotkb:Q80V90|uniprotkb:Q8C5P1|uniprotkb:Q8C859|uniprotkb:Q8C8P6|ensembl:ENSMUSP00000051492	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:setx_mouse(display_long)|uniprotkb:Setx(gene name)|psi-mi:Setx(display_short)|uniprotkb:Als4(gene name synonym)|uniprotkb:Kiaa0625(gene name synonym)|uniprotkb:SEN1 homolog(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 4 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000043535(gene)|ensembl:ENSMUST00000061578(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060566"(positive regulation of DNA-templated transcription, termination)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:0001147"(transcription termination site sequence-specific DNA binding)|go:"GO:2000806"("positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled")|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|mint:A2AKX3|refseq:NP_932150.2|dip:DIP-56995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:QQpfcvXSlNxIqCsJqONnS6sWQ2w10090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:1788-1798	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q921E6-3	uniprotkb:F7BJB9	intact:EBI-1896020	intact:EBI-2532106|ensembl:ENSMUSP00000040152|ensembl:ENSMUSP00000144369|uniprotkb:A6H605|uniprotkb:Q4QQR6|uniprotkb:Q6A0C2|uniprotkb:Q8R0R0	psi-mi:q921e6-3(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)|uniprotkb:EED-4(isoform synonym)	psi-mi:morc3_mouse(display_long)|uniprotkb:Morc3(gene name)|psi-mi:Morc3(display_short)|uniprotkb:Zcwcc3(gene name synonym)|uniprotkb:Nuclear matrix protein 2(gene name synonym)|uniprotkb:Nxp2(gene name synonym)|uniprotkb:Zinc finger CW-type coiled-coil domain protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2532014|imex:IM-12118-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-904301(isoform-parent)	ensembl:ENSMUSG00000039456(gene)|ensembl:ENSMUST00000044068(transcript)|ensembl:ENSMUST00000202261(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036890|interpro:IPR041006|rcsb pdb:5IX1|rcsb pdb:5IX2|refseq:NP_001038994.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:IDC5trnSI3nzAQhrE4Gq37YpMJI10090	rogid:XDL2XHXOy/OYhJGvWOIBLo8ghlY10090	intact-crc:E86DCD2BA1E49983|rigid:p2jooKOGudZpOlDutZDD1NjmZyM	false	flag tag:?-?|biotin tag:?-?	identified peptide:140-152|identified peptide:181-191|identified peptide:221-231|identified peptide:390-404|identified peptide:527-545|identified peptide:547-558|identified peptide:639-657|identified peptide:704-713|identified peptide:810-824	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P70351	uniprotkb:Q921E6	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535691|imex:IM-12118-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:C9263B169149E182|rigid:LuE1ECtWWF3FvmCfbnBpn5zIA2A	false	flag tag:?-?|biotin tag:?-?	identified peptide:107-120|identified peptide:185-197|identified peptide:185-197|identified peptide:217-236|identified peptide:343-355	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P70351	uniprotkb:Q02395	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535691|imex:IM-12118-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	intact-crc:C9263B169149E182|rigid:LuE1ECtWWF3FvmCfbnBpn5zIA2A	false	flag tag:?-?|biotin tag:?-?	identified peptide:417-424|identified peptide:488-497|identified peptide:550-561	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P70351	uniprotkb:Q60972	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	intact:EBI-302291|uniprotkb:A2A875|ensembl:ENSMUSP00000099658	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:rbbp4_mouse(display_long)|uniprotkb:Rbbp4(gene name)|psi-mi:Rbbp4(display_short)|uniprotkb:Rbap48(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535691|imex:IM-12118-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	ensembl:ENSMUSG00000057236(gene)|ensembl:ENSMUST00000102598(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60972|reactome:R-MMU-1538133|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8953750|refseq:NP_033056.2|dip:DIP-32855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I10090	intact-crc:C9263B169149E182|rigid:LuE1ECtWWF3FvmCfbnBpn5zIA2A	false	flag tag:?-?|biotin tag:?-?	identified peptide:144-156|identified peptide:252-258|identified peptide:297-304|identified peptide:341-350	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P70351	uniprotkb:Q9Z248	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	intact:EBI-2526952|uniprotkb:Q6PF91|uniprotkb:Q78HB0|uniprotkb:Q8BGV1|uniprotkb:Q8CE51|ensembl:ENSMUSP00000092993	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:aebp2_mouse(display_long)|uniprotkb:Aebp2(gene name)|psi-mi:Aebp2(display_short)|uniprotkb:Adipocyte enhancer-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535691|imex:IM-12118-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	ensembl:ENSMUSG00000030232(gene)|ensembl:ENSMUST00000095350(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-212300|reactome:R-MMU-3214841|refseq:NP_001005605.1|refseq:NP_001296365.1|refseq:NP_001296366.1|refseq:NP_033767.2|refseq:NP_848918.1|refseq:XP_006506969.1|refseq:XP_006506972.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	rogid:/WahLrADSj075nV+/m/6Up+FaoI10090	intact-crc:C9263B169149E182|rigid:LuE1ECtWWF3FvmCfbnBpn5zIA2A	false	flag tag:?-?|biotin tag:?-?	identified peptide:297-310|identified peptide:383-400|identified peptide:476-487	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P70351	uniprotkb:Q80U70	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535691|imex:IM-12118-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:C9263B169149E182|rigid:LuE1ECtWWF3FvmCfbnBpn5zIA2A	false	flag tag:?-?|biotin tag:?-?	identified peptide:106-115|identified peptide:6-40|identified peptide:133-142|identified peptide:249-255|identified peptide:296-306|identified peptide:345-362|identified peptide:406-415|identified peptide:540-557|sufficient binding region:598-613|identified peptide:723-734	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P70351	uniprotkb:Q62315	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535691|imex:IM-12118-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:C9263B169149E182|rigid:LuE1ECtWWF3FvmCfbnBpn5zIA2A	false	flag tag:?-?|biotin tag:?-?	identified peptide:132-149|identified peptide:15-27|identified peptide:58-69	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P70351	uniprotkb:Q91VJ4	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	intact:EBI-2527046|ensembl:ENSMUSP00000009138|ensembl:ENSMUSP00000113657|ensembl:ENSMUSP00000156711	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:stk38_mouse(display_long)|uniprotkb:Stk38(gene name)|psi-mi:Stk38(display_short)|uniprotkb:Ndr1(gene name synonym)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535691|imex:IM-12118-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q91VJ4|reactome:R-MMU-9013418|reactome:R-MMU-9013422|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSMUSG00000024006(gene)|ensembl:ENSMUST00000009138(transcript)|ensembl:ENSMUST00000119274(transcript)|ensembl:ENSMUST00000232836(transcript)|refseq:NP_598876.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	rogid:TvwVb4eUVw+H1smxX4+Z3LjcAUw10090	intact-crc:C9263B169149E182|rigid:LuE1ECtWWF3FvmCfbnBpn5zIA2A	false	flag tag:?-?|biotin tag:?-?	identified peptide:392-402|identified peptide:181-211|identified peptide:212-223	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:A2AKX3	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2532140|uniprotkb:A2AKX4|uniprotkb:A2AR33|uniprotkb:Q6IMG6|uniprotkb:Q6PED8|uniprotkb:Q6ZQ81|uniprotkb:Q80V90|uniprotkb:Q8C5P1|uniprotkb:Q8C859|uniprotkb:Q8C8P6|ensembl:ENSMUSP00000051492	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:setx_mouse(display_long)|uniprotkb:Setx(gene name)|psi-mi:Setx(display_short)|uniprotkb:Als4(gene name synonym)|uniprotkb:Kiaa0625(gene name synonym)|uniprotkb:SEN1 homolog(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 4 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	ensembl:ENSMUSG00000043535(gene)|ensembl:ENSMUST00000061578(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060566"(positive regulation of DNA-templated transcription, termination)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:0001147"(transcription termination site sequence-specific DNA binding)|go:"GO:2000806"("positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled")|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|mint:A2AKX3|refseq:NP_932150.2|dip:DIP-56995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:QQpfcvXSlNxIqCsJqONnS6sWQ2w10090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:1788-1798	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:Q62315	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:132-149|identified peptide:15-27|identified peptide:58-69	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:Q02395	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:417-424|identified peptide:488-497|identified peptide:550-561	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:Q60972	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-302291|uniprotkb:A2A875|ensembl:ENSMUSP00000099658	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:rbbp4_mouse(display_long)|uniprotkb:Rbbp4(gene name)|psi-mi:Rbbp4(display_short)|uniprotkb:Rbap48(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	ensembl:ENSMUSG00000057236(gene)|ensembl:ENSMUST00000102598(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60972|reactome:R-MMU-1538133|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8953750|refseq:NP_033056.2|dip:DIP-32855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I10090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:144-156|identified peptide:252-258|identified peptide:297-304|identified peptide:341-350	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:Q80U70	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:106-115|identified peptide:6-40|identified peptide:133-142|identified peptide:249-255|identified peptide:296-306|identified peptide:345-362|identified peptide:406-415|identified peptide:540-557|sufficient binding region:598-613|identified peptide:723-734	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:Q9Z248	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2526952|uniprotkb:Q6PF91|uniprotkb:Q78HB0|uniprotkb:Q8BGV1|uniprotkb:Q8CE51|ensembl:ENSMUSP00000092993	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:aebp2_mouse(display_long)|uniprotkb:Aebp2(gene name)|psi-mi:Aebp2(display_short)|uniprotkb:Adipocyte enhancer-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	ensembl:ENSMUSG00000030232(gene)|ensembl:ENSMUST00000095350(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-212300|reactome:R-MMU-3214841|refseq:NP_001005605.1|refseq:NP_001296365.1|refseq:NP_001296366.1|refseq:NP_033767.2|refseq:NP_848918.1|refseq:XP_006506969.1|refseq:XP_006506972.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:/WahLrADSj075nV+/m/6Up+FaoI10090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:297-310|identified peptide:383-400|identified peptide:476-487	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:F7BJB9	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2532106|ensembl:ENSMUSP00000040152|ensembl:ENSMUSP00000144369|uniprotkb:A6H605|uniprotkb:Q4QQR6|uniprotkb:Q6A0C2|uniprotkb:Q8R0R0	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:morc3_mouse(display_long)|uniprotkb:Morc3(gene name)|psi-mi:Morc3(display_short)|uniprotkb:Zcwcc3(gene name synonym)|uniprotkb:Nuclear matrix protein 2(gene name synonym)|uniprotkb:Nxp2(gene name synonym)|uniprotkb:Zinc finger CW-type coiled-coil domain protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	ensembl:ENSMUSG00000039456(gene)|ensembl:ENSMUST00000044068(transcript)|ensembl:ENSMUST00000202261(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036890|interpro:IPR041006|rcsb pdb:5IX1|rcsb pdb:5IX2|refseq:NP_001038994.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:XDL2XHXOy/OYhJGvWOIBLo8ghlY10090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:181-191|identified peptide:221-231|identified peptide:390-404|identified peptide:527-545|identified peptide:547-558|identified peptide:639-657|identified peptide:704-713|identified peptide:810-824|identified peptide:140-152	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:Q60973	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-302297|ensembl:ENSMUSP00000033720|uniprotkb:Q3UX20|uniprotkb:A2AFJ0	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:rbbp7_mouse(display_long)|uniprotkb:Rbbp7(gene name)|psi-mi:Rbbp7(display_short)|uniprotkb:Rbap46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60973|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-3214847|reactome:R-MMU-3214858|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8951664|reactome:R-MMU-8953750|ensembl:ENSMUSG00000031353(gene)|ensembl:ENSMUST00000033720(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006338"(chromatin remodeling)|refseq:NP_033057.3|dip:DIP-32856N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:+OV9hWS13A8fAypZJAXf656Z25U10090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:5-14|identified peptide:131-142|identified peptide:349-375	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:Q91VJ4	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2527046|ensembl:ENSMUSP00000009138|ensembl:ENSMUSP00000113657|ensembl:ENSMUSP00000156711	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:stk38_mouse(display_long)|uniprotkb:Stk38(gene name)|psi-mi:Stk38(display_short)|uniprotkb:Ndr1(gene name synonym)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q91VJ4|reactome:R-MMU-9013418|reactome:R-MMU-9013422|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSMUSG00000024006(gene)|ensembl:ENSMUST00000009138(transcript)|ensembl:ENSMUST00000119274(transcript)|ensembl:ENSMUST00000232836(transcript)|refseq:NP_598876.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:TvwVb4eUVw+H1smxX4+Z3LjcAUw10090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:181-211|identified peptide:212-223	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:Q8C006	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2536044|uniprotkb:A6H681|uniprotkb:Q6ZPY0|uniprotkb:Q7TQL7|uniprotkb:Q810V7|uniprotkb:Q8BVY9|uniprotkb:Q8VID4|uniprotkb:Q9CW74|uniprotkb:Q9D208	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:tri35_mouse(display_long)|uniprotkb:Trim35(gene name)|psi-mi:Trim35(display_short)|uniprotkb:Hls5(gene name synonym)|uniprotkb:Kiaa1098(gene name synonym)|uniprotkb:Mair(gene name synonym)|uniprotkb:Macrophage-derived apoptosis-inducing RBCC protein(gene name synonym)|uniprotkb:Protein Nc8(gene name synonym)|uniprotkb:Hemopoietic lineage switch protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902187"|refseq:NP_084255.2|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:2Lpwh2vfOvWvs86AE8hPP9Z2IAA10090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:226-236|identified peptide:295-316	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q61188	uniprotkb:Q921E6	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2535911|imex:IM-12118-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:57AB38462C7DA22E|rigid:7u1eLYBH7WTs9nHK0uxjc3C0Ukw	false	flag tag:?-?|biotin tag:?-?	identified peptide:108-120|identified peptide:185-197|identified peptide:202-211|identified peptide:294-302|identified peptide:343-355|identified peptide:376-385	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:P70351	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:40-48|identified peptide:53-62|identified peptide:385-406|identified peptide:467-474|sufficient binding region:481-492|identified peptide:729-742	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q02395	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:417-424|identified peptide:488-497|identified peptide:550-561	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q60972	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-302291|uniprotkb:A2A875|ensembl:ENSMUSP00000099658	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:rbbp4_mouse(display_long)|uniprotkb:Rbbp4(gene name)|psi-mi:Rbbp4(display_short)|uniprotkb:Rbap48(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000057236(gene)|ensembl:ENSMUST00000102598(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60972|reactome:R-MMU-1538133|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8953750|refseq:NP_033056.2|dip:DIP-32855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:144-156|identified peptide:252-258|identified peptide:297-304|identified peptide:341-350	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q80U70	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:106-115|identified peptide:6-40|identified peptide:133-142|identified peptide:249-255|identified peptide:296-306|identified peptide:345-362|identified peptide:406-415|identified peptide:540-557|sufficient binding region:598-613|identified peptide:723-734	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q9Z248	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2526952|uniprotkb:Q6PF91|uniprotkb:Q78HB0|uniprotkb:Q8BGV1|uniprotkb:Q8CE51|ensembl:ENSMUSP00000092993	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:aebp2_mouse(display_long)|uniprotkb:Aebp2(gene name)|psi-mi:Aebp2(display_short)|uniprotkb:Adipocyte enhancer-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000030232(gene)|ensembl:ENSMUST00000095350(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-212300|reactome:R-MMU-3214841|refseq:NP_001005605.1|refseq:NP_001296365.1|refseq:NP_001296366.1|refseq:NP_033767.2|refseq:NP_848918.1|refseq:XP_006506969.1|refseq:XP_006506972.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:/WahLrADSj075nV+/m/6Up+FaoI10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:297-310|identified peptide:383-400|identified peptide:476-487	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:F7BJB9	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2532106|ensembl:ENSMUSP00000040152|ensembl:ENSMUSP00000144369|uniprotkb:A6H605|uniprotkb:Q4QQR6|uniprotkb:Q6A0C2|uniprotkb:Q8R0R0	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:morc3_mouse(display_long)|uniprotkb:Morc3(gene name)|psi-mi:Morc3(display_short)|uniprotkb:Zcwcc3(gene name synonym)|uniprotkb:Nuclear matrix protein 2(gene name synonym)|uniprotkb:Nxp2(gene name synonym)|uniprotkb:Zinc finger CW-type coiled-coil domain protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000039456(gene)|ensembl:ENSMUST00000044068(transcript)|ensembl:ENSMUST00000202261(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036890|interpro:IPR041006|rcsb pdb:5IX1|rcsb pdb:5IX2|refseq:NP_001038994.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:XDL2XHXOy/OYhJGvWOIBLo8ghlY10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:140-152|identified peptide:181-191|identified peptide:221-231|identified peptide:390-404|identified peptide:527-545|identified peptide:547-558|identified peptide:639-657|identified peptide:704-713|identified peptide:810-824	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q91VJ4	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2527046|ensembl:ENSMUSP00000009138|ensembl:ENSMUSP00000113657|ensembl:ENSMUSP00000156711	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:stk38_mouse(display_long)|uniprotkb:Stk38(gene name)|psi-mi:Stk38(display_short)|uniprotkb:Ndr1(gene name synonym)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q91VJ4|reactome:R-MMU-9013418|reactome:R-MMU-9013422|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSMUSG00000024006(gene)|ensembl:ENSMUST00000009138(transcript)|ensembl:ENSMUST00000119274(transcript)|ensembl:ENSMUST00000232836(transcript)|refseq:NP_598876.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:TvwVb4eUVw+H1smxX4+Z3LjcAUw10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:212-223|identified peptide:181-211	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:E9Q286	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2536357|ensembl:ENSMUSP00000036482|uniprotkb:Q6ZQ20	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ice1_mouse(display_long)|uniprotkb:Ice1(gene name)|psi-mi:Ice1(display_short)|uniprotkb:Interactor of little elongator complex ELL subunit 1(gene name synonym)|uniprotkb:Kiaa0947(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000034525(gene)|ensembl:ENSMUST00000043493(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0035327"|go:"GO:0035363"(histone locus body)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0042796"(snRNA transcription by RNA polymerase III)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0090316"(positive regulation of intracellular protein transport)|reactome:R-MMU-6807505|refseq:NP_659086.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:no2gsyUHgQMxk0W9a5Q3NWQQVhM10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:529-539|identified peptide:648-655|identified peptide:681-690|identified peptide:693-701|identified peptide:727-736|identified peptide:893-904|identified peptide:1541-1560|identified peptide:1717-1728	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q7TSE6	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2536312|uniprotkb:Q6P6K6|uniprotkb:Q8BWK4|uniprotkb:B2KFR4|ensembl:ENSMUSP00000001675	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:st38l_mouse(display_long)|uniprotkb:Stk38l(gene name)|psi-mi:Stk38l(display_short)|uniprotkb:Ndr2(gene name synonym)|uniprotkb:NDR2 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000001630(gene)|ensembl:ENSMUST00000001675(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003779"(actin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051128"(regulation of cellular component organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|refseq:NP_766322.1|refseq:XP_006507090.2|refseq:NP_001333595.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:IRBWXfrZv3/BCGzPjopPQO4R1hw10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:73-79|identified peptide:153-160|identified peptide:435-444	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q8K019	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2536273|uniprotkb:Q8C2E9|uniprotkb:Q9CSW5|uniprotkb:Q8BNZ0|ensembl:ENSMUSP00000043583	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:bclf1_mouse(display_long)|uniprotkb:Bclaf1(gene name)|psi-mi:Bclaf1(display_short)|uniprotkb:Btf(gene name synonym)|uniprotkb:Kiaa0164(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000037608(gene)|ensembl:ENSMUST00000043881(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR026668|interpro:IPR029199|mint:Q8K019|refseq:NP_001020563.1|refseq:NP_722482.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:+9NQPsUgV77P3yH9iK0ZRDIOioM10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:318-330|identified peptide:568-578|identified peptide:621-629	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q569Z6	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2536252|ensembl:ENSMUSP00000079722	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:tr150_mouse(display_long)|uniprotkb:Thrap3(gene name)|psi-mi:Thrap3(display_short)|uniprotkb:Trap150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000043962(gene)|ensembl:ENSMUST00000080919(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR026667|interpro:IPR029199|go:"GO:0008380"(RNA splicing)|refseq:XP_011238805.1|refseq:NP_666265.3|refseq:XP_006503104.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:Cb0vHuEX3Ew27z2gvfC/36tdeYE10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:216-236|identified peptide:253-261|identified peptide:570-588|identified peptide:606-618	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:O08856	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-647129|uniprotkb:Q3TXY9|ensembl:ENSMUSP00000091163	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ell_mouse(display_long)|uniprotkb:Eleven-nineteen lysine-rich leukemia protein(gene name synonym)|uniprotkb:Ell(gene name)|psi-mi:Ell(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_031950.2|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035327"|go:"GO:0035363"(histone locus body)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0042796"(snRNA transcription by RNA polymerase III)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|interpro:IPR010844(Occludin and RNA polymerase II elongation factor ELL)|interpro:IPR019464|interpro:IPR031176|interpro:IPR031184|interpro:IPR036390|interpro:IPR042065|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-6796648|reactome:R-MMU-6807505|reactome:R-MMU-75955|ensembl:ENSMUSG00000070002(gene)|ensembl:ENSMUST00000093454(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:4GxbT6h5yA/Vv63XVYRjP9nQYAE10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:315-326|identified peptide:380-399|identified peptide:494-503|identified peptide:531-552	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q8C006	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2536044|uniprotkb:A6H681|uniprotkb:Q6ZPY0|uniprotkb:Q7TQL7|uniprotkb:Q810V7|uniprotkb:Q8BVY9|uniprotkb:Q8VID4|uniprotkb:Q9CW74|uniprotkb:Q9D208	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:tri35_mouse(display_long)|uniprotkb:Trim35(gene name)|psi-mi:Trim35(display_short)|uniprotkb:Hls5(gene name synonym)|uniprotkb:Kiaa1098(gene name synonym)|uniprotkb:Mair(gene name synonym)|uniprotkb:Macrophage-derived apoptosis-inducing RBCC protein(gene name synonym)|uniprotkb:Protein Nc8(gene name synonym)|uniprotkb:Hemopoietic lineage switch protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902187"|refseq:NP_084255.2|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:2Lpwh2vfOvWvs86AE8hPP9Z2IAA10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:71-84|identified peptide:134-145|identified peptide:175-195|identified peptide:226-236|identified peptide:283-290|identified peptide:295-330|identified peptide:479-487	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q921E6	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:107-120|identified peptide:185-197	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:A2AKX3	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2532140|uniprotkb:A2AKX4|uniprotkb:A2AR33|uniprotkb:Q6IMG6|uniprotkb:Q6PED8|uniprotkb:Q6ZQ81|uniprotkb:Q80V90|uniprotkb:Q8C5P1|uniprotkb:Q8C859|uniprotkb:Q8C8P6|ensembl:ENSMUSP00000051492	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:setx_mouse(display_long)|uniprotkb:Setx(gene name)|psi-mi:Setx(display_short)|uniprotkb:Als4(gene name synonym)|uniprotkb:Kiaa0625(gene name synonym)|uniprotkb:SEN1 homolog(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 4 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000043535(gene)|ensembl:ENSMUST00000061578(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060566"(positive regulation of DNA-templated transcription, termination)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:0001147"(transcription termination site sequence-specific DNA binding)|go:"GO:2000806"("positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled")|interpro:IPR027417|interpro:IPR041677|interpro:IPR041679|mint:A2AKX3|refseq:NP_932150.2|dip:DIP-56995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:QQpfcvXSlNxIqCsJqONnS6sWQ2w10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	identified peptide:1788-1798	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q61188	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536108|imex:IM-12118-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2016/02/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:E971DD16D9B33174|rigid:Oj5exuI57PEH97MJFuvkCvq+4oI	false	flag tag:?-?|biotin tag:?-?|identified peptide:58-69	sufficient binding region:53-61|identified peptide:65-78|identified peptide:420-441|identified peptide:715-727	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q02395	uniprotkb:Q91VJ4	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-2527046|ensembl:ENSMUSP00000009138|ensembl:ENSMUSP00000113657|ensembl:ENSMUSP00000156711	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:stk38_mouse(display_long)|uniprotkb:Stk38(gene name)|psi-mi:Stk38(display_short)|uniprotkb:Ndr1(gene name synonym)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536389|imex:IM-12118-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q91VJ4|reactome:R-MMU-9013418|reactome:R-MMU-9013422|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSMUSG00000024006(gene)|ensembl:ENSMUST00000009138(transcript)|ensembl:ENSMUST00000119274(transcript)|ensembl:ENSMUST00000232836(transcript)|refseq:NP_598876.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:TvwVb4eUVw+H1smxX4+Z3LjcAUw10090	intact-crc:9AA0B8D3E9071411|rigid:Nt4iWk9a8UBoCJWsrVvjQzhecng	false	flag tag:?-?|biotin tag:?-?	identified peptide:212-223|identified peptide:181-211	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q02395	uniprotkb:P70351	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536389|imex:IM-12118-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	intact-crc:9AA0B8D3E9071411|rigid:Nt4iWk9a8UBoCJWsrVvjQzhecng	false	flag tag:?-?|biotin tag:?-?	identified peptide:40-48|identified peptide:53-62|identified peptide:385-406|identified peptide:467-474|sufficient binding region:481-492|identified peptide:729-742	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q02395	uniprotkb:Q61188	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536389|imex:IM-12118-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:9AA0B8D3E9071411|rigid:Nt4iWk9a8UBoCJWsrVvjQzhecng	false	flag tag:?-?|biotin tag:?-?	sufficient binding region:53-61|identified peptide:65-78|identified peptide:420-441|identified peptide:715-727	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q02395	uniprotkb:Q80U70	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536389|imex:IM-12118-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:9AA0B8D3E9071411|rigid:Nt4iWk9a8UBoCJWsrVvjQzhecng	false	flag tag:?-?|biotin tag:?-?	identified peptide:106-115|identified peptide:6-40|identified peptide:133-142|identified peptide:249-255|identified peptide:296-306|identified peptide:345-362|identified peptide:406-415|identified peptide:540-557|sufficient binding region:598-613|identified peptide:723-734	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q02395	uniprotkb:Q921E6	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536389|imex:IM-12118-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:9AA0B8D3E9071411|rigid:Nt4iWk9a8UBoCJWsrVvjQzhecng	false	flag tag:?-?|biotin tag:?-?	identified peptide:107-120|identified peptide:185-197	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q02395	uniprotkb:O08856	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-647129|uniprotkb:Q3TXY9|ensembl:ENSMUSP00000091163	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:ell_mouse(display_long)|uniprotkb:Eleven-nineteen lysine-rich leukemia protein(gene name synonym)|uniprotkb:Ell(gene name)|psi-mi:Ell(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536389|imex:IM-12118-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	refseq:NP_031950.2|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035327"|go:"GO:0035363"(histone locus body)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0042796"(snRNA transcription by RNA polymerase III)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|interpro:IPR010844(Occludin and RNA polymerase II elongation factor ELL)|interpro:IPR019464|interpro:IPR031176|interpro:IPR031184|interpro:IPR036390|interpro:IPR042065|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-6796648|reactome:R-MMU-6807505|reactome:R-MMU-75955|ensembl:ENSMUSG00000070002(gene)|ensembl:ENSMUST00000093454(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:4GxbT6h5yA/Vv63XVYRjP9nQYAE10090	intact-crc:9AA0B8D3E9071411|rigid:Nt4iWk9a8UBoCJWsrVvjQzhecng	false	flag tag:?-?|biotin tag:?-?	identified peptide:315-326|identified peptide:380-399|identified peptide:494-503|identified peptide:531-552	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q02395	uniprotkb:E9Q286	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-2536357|ensembl:ENSMUSP00000036482|uniprotkb:Q6ZQ20	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:ice1_mouse(display_long)|uniprotkb:Ice1(gene name)|psi-mi:Ice1(display_short)|uniprotkb:Interactor of little elongator complex ELL subunit 1(gene name synonym)|uniprotkb:Kiaa0947(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536389|imex:IM-12118-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	ensembl:ENSMUSG00000034525(gene)|ensembl:ENSMUST00000043493(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0035327"|go:"GO:0035363"(histone locus body)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0042796"(snRNA transcription by RNA polymerase III)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0090316"(positive regulation of intracellular protein transport)|reactome:R-MMU-6807505|refseq:NP_659086.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:no2gsyUHgQMxk0W9a5Q3NWQQVhM10090	intact-crc:9AA0B8D3E9071411|rigid:Nt4iWk9a8UBoCJWsrVvjQzhecng	false	flag tag:?-?|biotin tag:?-?	identified peptide:529-539|identified peptide:648-655|identified peptide:681-690|identified peptide:693-701|identified peptide:727-736|identified peptide:893-904|identified peptide:1541-1560|identified peptide:1717-1728	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q02395	uniprotkb:Q8C006	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-2536044|uniprotkb:A6H681|uniprotkb:Q6ZPY0|uniprotkb:Q7TQL7|uniprotkb:Q810V7|uniprotkb:Q8BVY9|uniprotkb:Q8VID4|uniprotkb:Q9CW74|uniprotkb:Q9D208	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:tri35_mouse(display_long)|uniprotkb:Trim35(gene name)|psi-mi:Trim35(display_short)|uniprotkb:Hls5(gene name synonym)|uniprotkb:Kiaa1098(gene name synonym)|uniprotkb:Mair(gene name synonym)|uniprotkb:Macrophage-derived apoptosis-inducing RBCC protein(gene name synonym)|uniprotkb:Protein Nc8(gene name synonym)|uniprotkb:Hemopoietic lineage switch protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536389|imex:IM-12118-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902187"|refseq:NP_084255.2|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, Supp. Tables 1 and 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:2Lpwh2vfOvWvs86AE8hPP9Z2IAA10090	intact-crc:9AA0B8D3E9071411|rigid:Nt4iWk9a8UBoCJWsrVvjQzhecng	false	flag tag:?-?|biotin tag:?-?	identified peptide:71-84|identified peptide:134-145|identified peptide:175-195|identified peptide:226-236|identified peptide:283-290|identified peptide:295-330|identified peptide:479-487	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q62315	uniprotkb:Q02395	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536542|imex:IM-12118-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	intact-crc:115F2B239BB5DDED|rigid:rsmZ+e0wO0k8BpnrPpxKRZ0MjNw	false	ha tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62315	uniprotkb:Q921E6	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536542|imex:IM-12118-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:115F2B239BB5DDED|rigid:rsmZ+e0wO0k8BpnrPpxKRZ0MjNw	false	ha tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62315	uniprotkb:Q61188	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536542|imex:IM-12118-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:115F2B239BB5DDED|rigid:rsmZ+e0wO0k8BpnrPpxKRZ0MjNw	false	ha tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02395	uniprotkb:Q61188	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536557|imex:IM-12118-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:F8EDB598117BF66A|rigid:rsmZ+e0wO0k8BpnrPpxKRZ0MjNw	false	v5 tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02395	uniprotkb:Q921E6	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536557|imex:IM-12118-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:F8EDB598117BF66A|rigid:rsmZ+e0wO0k8BpnrPpxKRZ0MjNw	false	v5 tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02395	uniprotkb:Q62315	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536557|imex:IM-12118-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:F8EDB598117BF66A|rigid:rsmZ+e0wO0k8BpnrPpxKRZ0MjNw	false	v5 tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62315	uniprotkb:Q921E6	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536572|imex:IM-12118-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:3EBAADC62AE003B7|rigid:113u0hV5B/6ScMAoYKGYGaPR+Uk	false	ha tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02395	uniprotkb:P70351	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536581|imex:IM-12118-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	intact-crc:D967B83D286EC4E0|rigid:uyPDQ0Gg6jPdbLLv0RnFO/Tb4G4	false	v5 tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62315	uniprotkb:P70351	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536590|imex:IM-12118-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	intact-crc:A9A8245889B7BB02|rigid:fpESBAwQUNf7yq//nP0YWRb5AUw	false	ha tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q921E6	uniprotkb:Q62315	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536599|imex:IM-12118-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:23D0367FFCF43C42|rigid:113u0hV5B/6ScMAoYKGYGaPR+Uk	false	biotin tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q61188	uniprotkb:Q62315	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536608|imex:IM-12118-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:0370D330489B02C7|rigid:MOgWP0lQUQryVxvOgtf0MnANaa8	false	biotin tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62315	uniprotkb:Q61188	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536620|imex:IM-12118-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:F549415E1A2EA3B5|rigid:MOgWP0lQUQryVxvOgtf0MnANaa8	false	ha tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62315	uniprotkb:P70351	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2531737|uniprotkb:A2A4K5|uniprotkb:Q3TPR1|uniprotkb:Q3U3V5|uniprotkb:Q3UU02|uniprotkb:Q8BR85|uniprotkb:Q922L1|uniprotkb:Q9R089|ensembl:ENSMUSP00000102905	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh1_mouse(display_long)|uniprotkb:Ezh1(gene name)|psi-mi:Ezh1(display_short)|uniprotkb:Enx2(gene name synonym)|uniprotkb:Enhancer of zeste homolog 1(gene name synonym)|uniprotkb:ENX-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536635|imex:IM-12118-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	ensembl:ENSMUSG00000006920(gene)|ensembl:ENSMUST00000107284(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006348"|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1904772"(response to tetrachloromethane)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR032926|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044438|refseq:NP_031996.1|refseq:XP_006532241.1|dip:DIP-56992N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:89RbNTTe21Z9QhWU+oVxa8ECrtA10090	intact-crc:B0301FD13E411D9F|rigid:fpESBAwQUNf7yq//nP0YWRb5AUw	false	ha tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q61188	uniprotkb:Q02395	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536644|imex:IM-12118-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	intact-crc:E7D5B744DBFC1D9C|rigid:bIxISZtuKLtY00iOdUL7r4fQ0as	false	v5 tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02395	uniprotkb:Q921E6	intact:EBI-2531578|uniprotkb:Q569Z8|uniprotkb:Q6PG89|uniprotkb:Q8BGP9|uniprotkb:Q8BSJ7|ensembl:ENSMUSP00000080278|uniprotkb:Q05C61	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:mtf2_mouse(display_long)|uniprotkb:Mtf2(gene name)|psi-mi:Mtf2(display_short)|uniprotkb:Pcl2(gene name synonym)|uniprotkb:Zinc-regulated factor 1(gene name synonym)|uniprotkb:Metal-response element DNA-binding protein M96(gene name synonym)|uniprotkb:Metal regulatory transcription factor 2(gene name synonym)|uniprotkb:Polycomb-like protein 2(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536653|imex:IM-12118-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240806.1|refseq:NP_001240807.1|refseq:NP_001240808.1|refseq:NP_001240809.1|ensembl:ENSMUSG00000029267(gene)|ensembl:ENSMUST00000081567(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR025894|interpro:IPR040477|interpro:IPR042014|rcsb pdb:2EQJ|rcsb pdb:2YT5|reactome:R-MMU-212300|interpro:IPR042015|refseq:XP_011247718.1|refseq:NP_038855.2|refseq:XP_017176193.1|refseq:XP_017176194.1|dip:DIP-56991N	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/01/18	2014/10/16	rogid:kBGqJsYOFZWUzaGEEm3h5zMcYR010090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:485956469DC00930|rigid:rpH7oc2+dTvUu6ISHjfofupJLCc	false	v5 tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q61188	uniprotkb:Q62315	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2536685|imex:IM-12118-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:FABDD69CECE5D88D|rigid:MOgWP0lQUQryVxvOgtf0MnANaa8	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q61188	uniprotkb:Q80U70	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547083|imex:IM-12118-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G, Supp. Fig. 1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:B0ED23ED632C8A41|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61188	uniprotkb:Q62315	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547083|imex:IM-12118-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G, Supp. Fig. 1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:B0ED23ED632C8A41|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61188	uniprotkb:Q80U70	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547090|imex:IM-12118-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:F68AC41861A2F30C|rigid:2b0C3Xip1xCHc33fV2n8JaEzBs4	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q61188	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547097|imex:IM-12118-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:2ECFE4D4A29745F8|rigid:MOgWP0lQUQryVxvOgtf0MnANaa8	false	-	biotin tag:?-?|necessary binding region:611..611-731..731(IPR001214)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q921E6	uniprotkb:Q80U70	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547236|imex:IM-12118-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:D68955484D8A9CFD|rigid:DES7qooVyD4ld0Ure+78QIvFfvc	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q921E6	uniprotkb:Q62315	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547236|imex:IM-12118-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:D68955484D8A9CFD|rigid:DES7qooVyD4ld0Ure+78QIvFfvc	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q921E6	uniprotkb:Q80U70	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547311|imex:IM-12118-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:9451515DDB6740B1|rigid:H2JHUs2wD9IZhHN3HUdYdvcdJrM	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q921E6	uniprotkb:Q61188	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547311|imex:IM-12118-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:9451515DDB6740B1|rigid:H2JHUs2wD9IZhHN3HUdYdvcdJrM	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q921E6	uniprotkb:Q60972	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	intact:EBI-302291|uniprotkb:A2A875|ensembl:ENSMUSP00000099658	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:rbbp4_mouse(display_long)|uniprotkb:Rbbp4(gene name)|psi-mi:Rbbp4(display_short)|uniprotkb:Rbap48(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547311|imex:IM-12118-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	ensembl:ENSMUSG00000057236(gene)|ensembl:ENSMUST00000102598(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60972|reactome:R-MMU-1538133|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8953750|refseq:NP_033056.2|dip:DIP-32855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I10090	intact-crc:9451515DDB6740B1|rigid:H2JHUs2wD9IZhHN3HUdYdvcdJrM	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q921E6	uniprotkb:Q9Z248	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	intact:EBI-2526952|uniprotkb:Q6PF91|uniprotkb:Q78HB0|uniprotkb:Q8BGV1|uniprotkb:Q8CE51|ensembl:ENSMUSP00000092993	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:aebp2_mouse(display_long)|uniprotkb:Aebp2(gene name)|psi-mi:Aebp2(display_short)|uniprotkb:Adipocyte enhancer-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547311|imex:IM-12118-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	ensembl:ENSMUSG00000030232(gene)|ensembl:ENSMUST00000095350(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-212300|reactome:R-MMU-3214841|refseq:NP_001005605.1|refseq:NP_001296365.1|refseq:NP_001296366.1|refseq:NP_033767.2|refseq:NP_848918.1|refseq:XP_006506969.1|refseq:XP_006506972.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	rogid:/WahLrADSj075nV+/m/6Up+FaoI10090	intact-crc:9451515DDB6740B1|rigid:H2JHUs2wD9IZhHN3HUdYdvcdJrM	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61188	uniprotkb:Q60972	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-302291|uniprotkb:A2A875|ensembl:ENSMUSP00000099658	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:rbbp4_mouse(display_long)|uniprotkb:Rbbp4(gene name)|psi-mi:Rbbp4(display_short)|uniprotkb:Rbap48(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547323|imex:IM-12118-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	ensembl:ENSMUSG00000057236(gene)|ensembl:ENSMUST00000102598(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q60972|reactome:R-MMU-1538133|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214815|reactome:R-MMU-3214841|reactome:R-MMU-606279|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-8953750|refseq:NP_033056.2|dip:DIP-32855N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|comment:Jarid2 was additionally isolated with this complex, but cthe presence of 2 flag-tagged bait proteins made this impossible to capture.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I10090	intact-crc:791F2FDC0E746E31|rigid:H2JHUs2wD9IZhHN3HUdYdvcdJrM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61188	uniprotkb:Q9Z248	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2526952|uniprotkb:Q6PF91|uniprotkb:Q78HB0|uniprotkb:Q8BGV1|uniprotkb:Q8CE51|ensembl:ENSMUSP00000092993	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:aebp2_mouse(display_long)|uniprotkb:Aebp2(gene name)|psi-mi:Aebp2(display_short)|uniprotkb:Adipocyte enhancer-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547323|imex:IM-12118-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	ensembl:ENSMUSG00000030232(gene)|ensembl:ENSMUST00000095350(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-212300|reactome:R-MMU-3214841|refseq:NP_001005605.1|refseq:NP_001296365.1|refseq:NP_001296366.1|refseq:NP_033767.2|refseq:NP_848918.1|refseq:XP_006506969.1|refseq:XP_006506972.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|comment:Jarid2 was additionally isolated with this complex, but cthe presence of 2 flag-tagged bait proteins made this impossible to capture.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:/WahLrADSj075nV+/m/6Up+FaoI10090	intact-crc:791F2FDC0E746E31|rigid:H2JHUs2wD9IZhHN3HUdYdvcdJrM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61188	uniprotkb:Q80U70	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547323|imex:IM-12118-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|comment:Jarid2 was additionally isolated with this complex, but cthe presence of 2 flag-tagged bait proteins made this impossible to capture.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:791F2FDC0E746E31|rigid:H2JHUs2wD9IZhHN3HUdYdvcdJrM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61188	uniprotkb:Q921E6	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547323|imex:IM-12118-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|comment:Jarid2 was additionally isolated with this complex, but cthe presence of 2 flag-tagged bait proteins made this impossible to capture.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:791F2FDC0E746E31|rigid:H2JHUs2wD9IZhHN3HUdYdvcdJrM	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80U70	uniprotkb:Q62315	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547251|imex:IM-12118-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1H|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	intact-crc:B0CD67680D7533B5|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80U70	uniprotkb:Q61188	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547251|imex:IM-12118-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1H|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:B0CD67680D7533B5|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q80U70	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547256|imex:IM-12118-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1I|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:811B37E635A1A5A6|rigid:5GkJRa/e6MSEzorS3TXzMX1fBRA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q61188	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547256|imex:IM-12118-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1I|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:811B37E635A1A5A6|rigid:5GkJRa/e6MSEzorS3TXzMX1fBRA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q921E6	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547256|imex:IM-12118-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1I|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:811B37E635A1A5A6|rigid:5GkJRa/e6MSEzorS3TXzMX1fBRA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q921E6	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904301|uniprotkb:P97462|ensembl:ENSMUSP00000102853|ensembl:ENSMUSP00000159149	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:eed_mouse(display_long)|uniprotkb:Eed(gene name)|psi-mi:Eed(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547262|imex:IM-12118-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_068676.1|dip:DIP-29523N|ensembl:ENSMUSG00000030619(gene)|ensembl:ENSMUST00000107234(transcript)|ensembl:ENSMUST00000238981(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016571"(histone methylation)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045120"(pronucleus)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037352|mint:Q921E6|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1I|comment:Observed in Ezh2 knock-out cells. Interaction with Suz12 is greatly reduced.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:iivsQ4n2lmgM33PVY8WJFQXLnEA10090	intact-crc:B55A5BFFE7466729|rigid:DES7qooVyD4ld0Ure+78QIvFfvc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q80U70	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547262|imex:IM-12118-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1I|comment:Observed in Ezh2 knock-out cells. Interaction with Suz12 is greatly reduced.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:B55A5BFFE7466729|rigid:DES7qooVyD4ld0Ure+78QIvFfvc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q61188	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547268|imex:IM-12118-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1I|comment:Observed in Eed knockout cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:D2F154719138D4FD|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q80U70	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547268|imex:IM-12118-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1I|comment:Observed in Eed knockout cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:D2F154719138D4FD|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q61188	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547281|imex:IM-12118-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1J|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:16469AEA3E439AA4|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q80U70	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547281|imex:IM-12118-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1J|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:16469AEA3E439AA4|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q61188	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-904311|uniprotkb:Q99L74|intact:EBI-2526787|uniprotkb:Q9R090|ensembl:ENSMUSP00000080419	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:ezh2_mouse(display_long)|uniprotkb:Ezh2(gene name)|psi-mi:Ezh2(display_short)|uniprotkb:Enx1h(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547293|imex:IM-12118-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_031997.2|dip:DIP-29524N|ensembl:ENSMUSG00000029687(gene)|ensembl:ENSMUST00000081721(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006348"|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0048511"(rhythmic process)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q61188|rcsb pdb:2QXV|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1J|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-f9)|taxid:10090(Mus musculus)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:g2SeyOX9aEEKepn2fS3eprvcixg10090	intact-crc:076BDD62FEEEE769|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62315	uniprotkb:Q80U70	intact:EBI-493592|uniprotkb:Q99LD1|uniprotkb:Q3TPU4|uniprotkb:Q3UHS7|ensembl:ENSMUSP00000037774|ensembl:ENSMUSP00000134205|ensembl:ENSMUSP00000134675	intact:EBI-2526494|uniprotkb:B1AQE5|uniprotkb:Q80Y10|uniprotkb:Q99L07|ensembl:ENSMUSP00000017692	psi-mi:jard2_mouse(display_long)|uniprotkb:Jumonji/ARID domain-containing protein 2(gene name synonym)|uniprotkb:Jarid2(gene name)|psi-mi:Jarid2(display_short)|uniprotkb:Jmj(gene name synonym)	psi-mi:suz12_mouse(display_long)|uniprotkb:Suz12(gene name)|psi-mi:Suz12(display_short)|uniprotkb:D11Ertd530e(gene name synonym)|uniprotkb:Kiaa0160(gene name synonym)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shen et al. (2009)	imex:IM-12118|pubmed:20064376	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2547293|imex:IM-12118-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191972.1|refseq:NP_001191973.1|refseq:NP_068678.1|refseq:XP_006516918.1|refseq:XP_006516919.1|refseq:XP_006516921.1|refseq:XP_006516922.1|refseq:XP_006516923.1|refseq:XP_017170888.1|ensembl:ENSMUSG00000038518(gene)|ensembl:ENSMUST00000044608(transcript)|ensembl:ENSMUST00000173246(transcript)|ensembl:ENSMUST00000173704(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0031061"(negative regulation of histone methylation)|go:"GO:0034721"(histone H3-K4 demethylation, trimethyl-H3-K4-specific)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR036431|mint:Q62315|rcsb pdb:2RQ5|reactome:R-MMU-212300|dip:DIP-34312N	refseq:NP_001156490.1|refseq:NP_954666.1|ensembl:ENSMUSG00000017548(gene)|ensembl:ENSMUST00000017692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016571"(histone methylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR019135|mint:Q80U70|reactome:R-MMU-212300|reactome:R-MMU-2559580|reactome:R-MMU-3214841|reactome:R-MMU-4551638|go:"GO:0048709"(oligodendrocyte differentiation)|reactome:R-MMU-8943724|reactome:R-MMU-8953750|dip:DIP-56045N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1J|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-f9)|taxid:10090(Mus musculus)	-	2010/01/18	2014/10/16	rogid:ptRtfBecVfi/6SPXXxet5ycZETo10090	rogid:yULk8oVce1HyiORkV/CZmoSb63010090	intact-crc:076BDD62FEEEE769|rigid:2IcS3uRvPCqqdxcCohJW8lZaavU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)