#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P35520 uniprotkb:P06821 intact:EBI-740135|uniprotkb:Q99425|uniprotkb:Q9BWC5|uniprotkb:B2R993|uniprotkb:D3DSK4|intact:EBI-14245939|ensembl:ENSP00000344460|ensembl:ENSP00000352643|ensembl:ENSP00000381225|ensembl:ENSP00000381231 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 psi-mi:cbs_human(display_long)|uniprotkb:CBS(gene name)|psi-mi:CBS(display_short)|uniprotkb:Serine sulfhydrase(gene name synonym)|uniprotkb:Beta-thionase(gene name synonym) psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547437|imex:IM-13585-164 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000062.1|refseq:NP_001171479.1|refseq:NP_001171480.1|ensembl:ENSG00000160200(gene)|ensembl:ENST00000352178(transcript)|ensembl:ENST00000359624(transcript)|ensembl:ENST00000398158(transcript)|go:"GO:0004122"(cystathionine beta-synthase activity)|ensembl:ENST00000398165(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0019343"(cysteine biosynthetic process via cystathionine)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0019346"(transsulfuration)|go:"GO:0019448"(L-cysteine catabolic process)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042262"(DNA protection)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043418"(homocysteine catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050421"("nitrite reductase (NO-forming) activity")|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0070025"(carbon monoxide binding)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070814"(hydrogen sulfide biosynthetic process)|go:"GO:0072341"(modified amino acid binding)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005857(Cystathionine beta-synthase)|interpro:IPR036052|mint:P35520|rcsb pdb:1JBQ|rcsb pdb:1M54|rcsb pdb:4COO|rcsb pdb:4L0D|rcsb pdb:4L27|rcsb pdb:4L28|rcsb pdb:4L3V|rcsb pdb:4PCU|rcsb pdb:4UUU|rcsb pdb:5MMS|reactome:R-HSA-1614603|reactome:R-HSA-2408508|refseq:XP_011528079.1|refseq:XP_011528083.1|refseq:XP_011528084.1|refseq:XP_011544396.1|refseq:XP_011544397.1|refseq:XP_011544399.1|refseq:XP_011544400.1|refseq:XP_011544401.1|refseq:NP_001307227.1|refseq:NP_001308002.1|refseq:XP_016883700.1|refseq:XP_016883701.1|refseq:XP_016883702.1|refseq:XP_016883703.1|refseq:XP_016883704.1|refseq:XP_016883705.1|refseq:XP_016883706.1|refseq:XP_016883707.1|refseq:XP_016883978.1|refseq:XP_016883979.1|refseq:XP_016883980.1|refseq:XP_016883981.1 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:f9eo0cPOHppVY7Nqejag3YyK18s9606 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 intact-crc:D6E4B72924C84E2E|rigid:nO9uTnWB88mvZUucimouAjAM/6A false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:Q8WYJ6 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-693002|uniprotkb:B4DVE6|uniprotkb:Q658T1|uniprotkb:Q8NEZ1|uniprotkb:Q96EL4|uniprotkb:Q9H285|ensembl:ENSP00000498586 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:sept1_human(display_long)|uniprotkb:SEPTIN1(gene name)|psi-mi:SEPTIN1(display_short)|uniprotkb:DIFF6(gene name synonym)|uniprotkb:LARP(gene name synonym)|uniprotkb:PNUTL3(gene name synonym)|uniprotkb:Peanut-like protein 3(gene name synonym)|uniprotkb:SEPT1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-24(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547470|imex:IM-13585-152 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 refseq:NP_443070.5|ensembl:ENSG00000180096(gene)|ensembl:ENST00000652617(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005940"(septin ring)|go:"GO:0007056"(spindle assembly involved in female meiosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0051311"(meiotic metaphase plate congression)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0072687"(meiotic spindle)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|rcsb pdb:6WBE go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2021/06/18 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:hw4il5ccV1YaEnJv0uROFaeKElE9606 intact-crc:610BDC5D668848A3|rigid:GjXt4WEPotxWW2tkrDBUqWbqImI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P02511 uniprotkb:P03428 intact:EBI-739060|uniprotkb:O43416|uniprotkb:B0YIX0|uniprotkb:Q9UC37|uniprotkb:Q9UC38|uniprotkb:Q9UC39|uniprotkb:Q9UC40|uniprotkb:Q9UC41|ensembl:ENSP00000227251|ensembl:ENSP00000433560|ensembl:ENSP00000434247|ensembl:ENSP00000435931|ensembl:ENSP00000436051|ensembl:ENSP00000436089|ensembl:ENSP00000437149|ensembl:ENSP00000483554|ensembl:ENSP00000498735|ensembl:ENSP00000499082 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:cryab_human(display_long)|uniprotkb:CRYAB(gene name)|psi-mi:CRYAB(display_short)|uniprotkb:CRYA2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-27(gene name synonym)|uniprotkb:"Alpha(B)-crystallin"(gene name synonym)|uniprotkb:Rosenthal fiber component(gene name synonym)|uniprotkb:Heat shock protein beta-5(gene name synonym)|uniprotkb:HSPB5(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547499|imex:IM-13585-197 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109846(gene)|ensembl:ENST00000227251(transcript)|ensembl:ENST00000526180(transcript)|ensembl:ENST00000527899(transcript)|ensembl:ENST00000527950(transcript)|ensembl:ENST00000531198(transcript)|ensembl:ENST00000533475(transcript)|ensembl:ENST00000533879(transcript)|ensembl:ENST00000616970(transcript)|ensembl:ENST00000650687(transcript)|ensembl:ENST00000651164(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006936"(muscle contraction)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031430"(M band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037882|mint:P02511|rcsb pdb:2KLR|rcsb pdb:2N0K|rcsb pdb:2WJ7|rcsb pdb:2Y1Y|rcsb pdb:2Y1Z|rcsb pdb:2YGD|rcsb pdb:3J07|rcsb pdb:2Y22|rcsb pdb:3L1G|rcsb pdb:3SGM|rcsb pdb:3SGN|rcsb pdb:3SGO|rcsb pdb:3SGP|rcsb pdb:3SGR|rcsb pdb:3SGS|rcsb pdb:4M5S|rcsb pdb:4M5T|rcsb pdb:5VVV|rcsb pdb:6BP9|reactome:R-HSA-3371571|refseq:NP_001876.1|refseq:XP_011540910.1|refseq:NP_001276736.1|refseq:NP_001276737.1|dip:DIP-35017N go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) crc64:AE08BED46B7849CB - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:495Z42oQhkAUdADrAEOKIC5oICo9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:7AB1EDF91302C042|rigid:wESqvhU8jRRh4TabjhWC7vQvlZU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14641 uniprotkb:P03428 intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547504|imex:IM-13585-228 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:EEF430026B9456BB|rigid:PrABswn8w0IToFHHzESGA4s8xqE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14641 uniprotkb:P06821 intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short) psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547509|imex:IM-13585-144 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 intact-crc:0EBFEDA28691E4F7|rigid:A7Dhj862RExiVECQEUySa69zM+s false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14641 uniprotkb:P03431 intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547538|imex:IM-13585-212 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:C33EB1A1C7C46A4D|rigid:PIT2EabwoJWcmgtrMCBYfMhxyH4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03485 uniprotkb:O14641 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3 psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547576|imex:IM-13585-155 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606 intact-crc:252E202394F213FB|rigid:TnMmOdjtbwzQMjB3xW4tNdldP/0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q92997 uniprotkb:P06821 intact:EBI-739789|uniprotkb:O14642|uniprotkb:Q13531|uniprotkb:Q8N5E9|uniprotkb:Q92607|uniprotkb:D3DNT0|intact:EBI-11081380|uniprotkb:B4E3E5|ensembl:ENSP00000316054 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym) psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547590|imex:IM-13585-143 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004414.3|dip:DIP-34509N|ensembl:ENSG00000161202(gene)|ensembl:ENST00000313143(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042493"|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q92997|rcsb pdb:6V7O|rcsb pdb:6ZC6|rcsb pdb:6ZC8|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 intact-crc:3EF482264459D9AB|rigid:M5nQyTJpQDWBfP5Yb5mvIkfhpkA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q92997 uniprotkb:P03428 intact:EBI-739789|uniprotkb:O14642|uniprotkb:Q13531|uniprotkb:Q8N5E9|uniprotkb:Q92607|uniprotkb:D3DNT0|intact:EBI-11081380|uniprotkb:B4E3E5|ensembl:ENSP00000316054 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547595|imex:IM-13585-145 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004414.3|dip:DIP-34509N|ensembl:ENSG00000161202(gene)|ensembl:ENST00000313143(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042493"|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q92997|rcsb pdb:6V7O|rcsb pdb:6ZC6|rcsb pdb:6ZC8|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:5AC274DAA02197CA|rigid:iT6YrIfjlzjH0yo7iRi1lPKMQMI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q92997 uniprotkb:P03485 intact:EBI-739789|uniprotkb:O14642|uniprotkb:Q13531|uniprotkb:Q8N5E9|uniprotkb:Q92607|uniprotkb:D3DNT0|intact:EBI-11081380|uniprotkb:B4E3E5|ensembl:ENSP00000316054 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547600|imex:IM-13585-146 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004414.3|dip:DIP-34509N|ensembl:ENSG00000161202(gene)|ensembl:ENST00000313143(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042493"|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q92997|rcsb pdb:6V7O|rcsb pdb:6ZC6|rcsb pdb:6ZC8|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:E2D4F2C313CC9495|rigid:5akbT5m3NxnShYkua9BG0Ze6Vgg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:Q92997 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-739789|uniprotkb:O14642|uniprotkb:Q13531|uniprotkb:Q8N5E9|uniprotkb:Q92607|uniprotkb:D3DNT0|intact:EBI-11081380|uniprotkb:B4E3E5|ensembl:ENSP00000316054 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547605|imex:IM-13585-167 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 refseq:NP_004414.3|dip:DIP-34509N|ensembl:ENSG00000161202(gene)|ensembl:ENST00000313143(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042493"|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q92997|rcsb pdb:6V7O|rcsb pdb:6ZC6|rcsb pdb:6ZC8|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606 intact-crc:5CA8D4D975F68351|rigid:L4w9xqgFMiK25UReGtA4Htz09y4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q06547 uniprotkb:P03431 intact:EBI-618165|ensembl:ENSP00000220429|uniprotkb:Q06545|uniprotkb:Q12940|uniprotkb:Q12941|uniprotkb:Q12942|uniprotkb:Q8IYD0|uniprotkb:A8IE52 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:gabp1_human(display_long)|uniprotkb:GABP subunit beta-2(gene name synonym)|uniprotkb:Transcription factor E4TF1-53(gene name synonym)|uniprotkb:Transcription factor E4TF1-47(gene name synonym)|uniprotkb:Nuclear respiratory factor 2(gene name synonym)|uniprotkb:GABPB1(gene name)|psi-mi:GABPB1(display_short)|uniprotkb:E4TF1B(gene name synonym)|uniprotkb:GABPB(gene name synonym)|uniprotkb:GABPB2(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547611|imex:IM-13585-151 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104064(gene)|ensembl:ENST00000220429(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q06547|reactome:R-HSA-2151201|refseq:NP_002032.2|refseq:NP_005245.2|refseq:NP_057738.1|refseq:NP_057739.1|refseq:NP_852092.1|refseq:NP_001307839.1|refseq:XP_005254331.1|refseq:XP_016877542.1|dip:DIP-33979N go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:JO5HOl2ohh7LmNIn5UyYNbGviYE9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:77596C0B55FD74C1|rigid:HzMoIfHfaSufFniiFgYHWFPLXXg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O00505 uniprotkb:P03433 intact:EBI-358297|intact:EBI-28976892|ensembl:ENSP00000261667|uniprotkb:O00191|uniprotkb:O43195|uniprotkb:Q96AA7|uniprotkb:Q5JVM9|intact:EBI-742146|uniprotkb:Q8IYQ9 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:ima4_human(display_long)|uniprotkb:KPNA3(gene name)|psi-mi:KPNA3(display_short)|uniprotkb:QIP2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)|uniprotkb:SRP1-gamma(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547634|imex:IM-13585-247 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102753(gene)|ensembl:ENST00000261667(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0043657"(host cell)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000225(Armadillo)|refseq:NP_002258.2|ensembl:ENSP00000261667|dip:DIP-27586N|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00505|reactome:R-HSA-1169408|reactome:R-HSA-168276 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:kx/oTYWMYG7dhwJHvr1POLD6FTU9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:1EE86D0B41DF7F53|rigid:g06NKldvbMIinwNa94G9o2e38uM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O00505 uniprotkb:P03466 intact:EBI-358297|intact:EBI-28976892|ensembl:ENSP00000261667|uniprotkb:O00191|uniprotkb:O43195|uniprotkb:Q96AA7|uniprotkb:Q5JVM9|intact:EBI-742146|uniprotkb:Q8IYQ9 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:ima4_human(display_long)|uniprotkb:KPNA3(gene name)|psi-mi:KPNA3(display_short)|uniprotkb:QIP2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)|uniprotkb:SRP1-gamma(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547670|imex:IM-13585-207 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102753(gene)|ensembl:ENST00000261667(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0043657"(host cell)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000225(Armadillo)|refseq:NP_002258.2|ensembl:ENSP00000261667|dip:DIP-27586N|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00505|reactome:R-HSA-1169408|reactome:R-HSA-168276 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:kx/oTYWMYG7dhwJHvr1POLD6FTU9606 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:AEBFDD0863FEB873|rigid:odmpawVJgugTLkJxOxKZnfyQAYo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:O00505 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-358297|intact:EBI-28976892|ensembl:ENSP00000261667|uniprotkb:O00191|uniprotkb:O43195|uniprotkb:Q96AA7|uniprotkb:Q5JVM9|intact:EBI-742146|uniprotkb:Q8IYQ9 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:ima4_human(display_long)|uniprotkb:KPNA3(gene name)|psi-mi:KPNA3(display_short)|uniprotkb:QIP2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)|uniprotkb:SRP1-gamma(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547676|imex:IM-13585-209 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 ensembl:ENSG00000102753(gene)|ensembl:ENST00000261667(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0043657"(host cell)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000225(Armadillo)|refseq:NP_002258.2|ensembl:ENSP00000261667|dip:DIP-27586N|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00505|reactome:R-HSA-1169408|reactome:R-HSA-168276 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:kx/oTYWMYG7dhwJHvr1POLD6FTU9606 intact-crc:ADBC26234DB69210|rigid:U98FXm2/zAQRV7XW3I/TxH/AfQo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14639 uniprotkb:P03433 intact:EBI-487024|uniprotkb:A6NI16|uniprotkb:Q5T6N3|uniprotkb:Q5JVV1|uniprotkb:Q15039|uniprotkb:Q68CQ9|uniprotkb:Q9BUP1|uniprotkb:Q5T6N5|uniprotkb:B3KVH2|uniprotkb:Q5T6N2|uniprotkb:A6NJ06|uniprotkb:A8MXA9|uniprotkb:Q5JVV2|ensembl:ENSP00000277895 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:ablm1_human(display_long)|uniprotkb:Actin-binding LIM protein family member 1(gene name synonym)|uniprotkb:Actin-binding double zinc finger protein(gene name synonym)|uniprotkb:Limatin(gene name synonym)|uniprotkb:ABLIM1(gene name)|psi-mi:ABLIM1(display_short)|uniprotkb:ABLIM(gene name synonym)|uniprotkb:KIAA0059(gene name synonym)|uniprotkb:LIMAB1(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547683|imex:IM-13585-122 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001003407.1|refseq:NP_002304.3|refseq:NP_006711.3|ensembl:ENSG00000099204(gene)|ensembl:ENST00000277895(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007601"(visual perception)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060271"(cilium assembly)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR003128(Villin headpiece)|interpro:IPR028448|interpro:IPR032402|interpro:IPR036886|mint:O14639|reactome:R-HSA-418885|go:"GO:0030032"(lamellipodium assembly)|refseq:NP_001309811.1|refseq:NP_001309821.1|refseq:NP_001309822.1|refseq:NP_001309825.1 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Dsx3GrmdlsYUmQvuW59NfYF7MJg9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:53F5A913A286A4CF|rigid:Pk6FTXtmo8PA5D6FOrJDOisJ5yU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P43360 uniprotkb:P03466 intact:EBI-1045155|uniprotkb:A8IF93|uniprotkb:Q6NW44|ensembl:ENSP00000329199|ensembl:ENSP00000480637 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:maga6_human(display_long)|uniprotkb:MAGE-6 antigen(gene name synonym)|uniprotkb:MAGE3B antigen(gene name synonym)|uniprotkb:Cancer/testis antigen 1.6(gene name synonym)|uniprotkb:MAGEA6(gene name)|psi-mi:MAGEA6(display_short)|uniprotkb:MAGE6(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547688|imex:IM-13585-196 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005354.1|refseq:NP_787064.1|ensembl:ENSG00000197172(gene)|ensembl:ENST00000329342(transcript)|ensembl:ENST00000616035(transcript)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR030097|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Ag4IF8+k8aF+zuiB7NwjRrGGH6E9606 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:3F7B5D9DD2F9DE5E|rigid:MzsslkW8KbIysF0wV+glxUj6lIU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P43360 uniprotkb:P03428 intact:EBI-1045155|uniprotkb:A8IF93|uniprotkb:Q6NW44|ensembl:ENSP00000329199|ensembl:ENSP00000480637 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:maga6_human(display_long)|uniprotkb:MAGE-6 antigen(gene name synonym)|uniprotkb:MAGE3B antigen(gene name synonym)|uniprotkb:Cancer/testis antigen 1.6(gene name synonym)|uniprotkb:MAGEA6(gene name)|psi-mi:MAGEA6(display_short)|uniprotkb:MAGE6(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547693|imex:IM-13585-165 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005354.1|refseq:NP_787064.1|ensembl:ENSG00000197172(gene)|ensembl:ENST00000329342(transcript)|ensembl:ENST00000616035(transcript)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR030097|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Ag4IF8+k8aF+zuiB7NwjRrGGH6E9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:0623123330C1347D|rigid:GI1we3CDLXaCrnKdJaXQs/dHO/E false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03466 uniprotkb:P43360 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 intact:EBI-1045155|uniprotkb:A8IF93|uniprotkb:Q6NW44|ensembl:ENSP00000329199|ensembl:ENSP00000480637 psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:maga6_human(display_long)|uniprotkb:MAGE-6 antigen(gene name synonym)|uniprotkb:MAGE3B antigen(gene name synonym)|uniprotkb:Cancer/testis antigen 1.6(gene name synonym)|uniprotkb:MAGEA6(gene name)|psi-mi:MAGEA6(display_short)|uniprotkb:MAGE6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547698|imex:IM-13585-208 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 refseq:NP_005354.1|refseq:NP_787064.1|ensembl:ENSG00000197172(gene)|ensembl:ENST00000329342(transcript)|ensembl:ENST00000616035(transcript)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR030097|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 rogid:Ag4IF8+k8aF+zuiB7NwjRrGGH6E9606 intact-crc:3F7B5D9DD2F9DE5E|rigid:MzsslkW8KbIysF0wV+glxUj6lIU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P43364 uniprotkb:P03466 intact:EBI-739552|uniprotkb:Q5ETU4|uniprotkb:Q6ZRZ5|ensembl:ENSP00000347358 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:magab_human(display_long)|uniprotkb:MAGEA11(gene name)|psi-mi:MAGEA11(display_short)|uniprotkb:MAGE11(gene name synonym)|uniprotkb:MAGE-11 antigen(gene name synonym)|uniprotkb:Cancer/testis antigen 1.11(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547703|imex:IM-13585-211 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001011544.1|refseq:NP_005357.2|ensembl:ENSG00000185247(gene)|ensembl:ENST00000355220(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR030099|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:P43364|rcsb pdb:6WJH|refseq:XP_016885010.1|refseq:XP_016885011.1 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:S0eOQssWhZCbAvWQCub2H+zQmzs9606 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:DB3C70192B7E0A5F|rigid:0g+t9nGpyLQONMUscGQysslqnLo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P43364 uniprotkb:P03431 intact:EBI-739552|uniprotkb:Q5ETU4|uniprotkb:Q6ZRZ5|ensembl:ENSP00000347358 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:magab_human(display_long)|uniprotkb:MAGEA11(gene name)|psi-mi:MAGEA11(display_short)|uniprotkb:MAGE11(gene name synonym)|uniprotkb:MAGE-11 antigen(gene name synonym)|uniprotkb:Cancer/testis antigen 1.11(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547714|imex:IM-13585-210 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001011544.1|refseq:NP_005357.2|ensembl:ENSG00000185247(gene)|ensembl:ENST00000355220(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR030099|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:P43364|rcsb pdb:6WJH|refseq:XP_016885010.1|refseq:XP_016885011.1 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:S0eOQssWhZCbAvWQCub2H+zQmzs9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:E40E9FB41C91F4E7|rigid:cL3XedH1bdnYTJJ1lSP9Do8t4Zg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:P43364 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-739552|uniprotkb:Q5ETU4|uniprotkb:Q6ZRZ5|ensembl:ENSP00000347358 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:magab_human(display_long)|uniprotkb:MAGEA11(gene name)|psi-mi:MAGEA11(display_short)|uniprotkb:MAGE11(gene name synonym)|uniprotkb:MAGE-11 antigen(gene name synonym)|uniprotkb:Cancer/testis antigen 1.11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547719|imex:IM-13585-192 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:NP_001011544.1|refseq:NP_005357.2|ensembl:ENSG00000185247(gene)|ensembl:ENST00000355220(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR030099|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:P43364|rcsb pdb:6WJH|refseq:XP_016885010.1|refseq:XP_016885011.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:S0eOQssWhZCbAvWQCub2H+zQmzs9606 intact-crc:E2643FB7C946E07C|rigid:YeNFIYzDVbdn9f5hw3Zt1e+3Gy0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P50222 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-748397|uniprotkb:O75263|ensembl:ENSP00000262041|uniprotkb:Q9UPL6|uniprotkb:B2R8I7|intact:EBI-10172134|intact:EBI-11522964|intact:EBI-11750003|intact:EBI-12702266|uniprotkb:A4D127 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:meox2_human(display_long)|uniprotkb:Mesenchyme homeobox 2(gene name synonym)|uniprotkb:Growth arrest-specific homeobox(gene name synonym)|uniprotkb:MEOX2(gene name)|psi-mi:MEOX2(display_short)|uniprotkb:GAX(gene name synonym)|uniprotkb:MOX2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547724|imex:IM-13585-213 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 ensembl:ENSG00000106511(gene)|ensembl:ENST00000262041(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008015"(blood circulation)|go:"GO:0016607"(nuclear speck)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0061053"(somite development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR042634|refseq:NP_005915.2 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:fMv0ruKikzQ3MC0PBvJ3pOAjW+U9606 intact-crc:FD478841B1011B70|rigid:yt1KebM3UINQ4UkCB+kRvl0FukI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P50222 uniprotkb:P03433 intact:EBI-748397|uniprotkb:O75263|ensembl:ENSP00000262041|uniprotkb:Q9UPL6|uniprotkb:B2R8I7|intact:EBI-10172134|intact:EBI-11522964|intact:EBI-11750003|intact:EBI-12702266|uniprotkb:A4D127 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:meox2_human(display_long)|uniprotkb:Mesenchyme homeobox 2(gene name synonym)|uniprotkb:Growth arrest-specific homeobox(gene name synonym)|uniprotkb:MEOX2(gene name)|psi-mi:MEOX2(display_short)|uniprotkb:GAX(gene name synonym)|uniprotkb:MOX2(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547729|imex:IM-13585-233 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106511(gene)|ensembl:ENST00000262041(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008015"(blood circulation)|go:"GO:0016607"(nuclear speck)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0061053"(somite development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR042634|refseq:NP_005915.2 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:fMv0ruKikzQ3MC0PBvJ3pOAjW+U9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:791A19C326DDB0BA|rigid:pLXgpCzEEblocU5Or8rx5NgZazc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P50222 uniprotkb:P03485 intact:EBI-748397|uniprotkb:O75263|ensembl:ENSP00000262041|uniprotkb:Q9UPL6|uniprotkb:B2R8I7|intact:EBI-10172134|intact:EBI-11522964|intact:EBI-11750003|intact:EBI-12702266|uniprotkb:A4D127 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:meox2_human(display_long)|uniprotkb:Mesenchyme homeobox 2(gene name synonym)|uniprotkb:Growth arrest-specific homeobox(gene name synonym)|uniprotkb:MEOX2(gene name)|psi-mi:MEOX2(display_short)|uniprotkb:GAX(gene name synonym)|uniprotkb:MOX2(gene name synonym) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547734|imex:IM-13585-142 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106511(gene)|ensembl:ENST00000262041(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008015"(blood circulation)|go:"GO:0016607"(nuclear speck)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0061053"(somite development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR042634|refseq:NP_005915.2 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:fMv0ruKikzQ3MC0PBvJ3pOAjW+U9606 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:433BAE5BD73B0CB4|rigid:EFUUMlKV/dXkmB7VAu7SCsxmLCI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P50222 uniprotkb:P06821 intact:EBI-748397|uniprotkb:O75263|ensembl:ENSP00000262041|uniprotkb:Q9UPL6|uniprotkb:B2R8I7|intact:EBI-10172134|intact:EBI-11522964|intact:EBI-11750003|intact:EBI-12702266|uniprotkb:A4D127 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 psi-mi:meox2_human(display_long)|uniprotkb:Mesenchyme homeobox 2(gene name synonym)|uniprotkb:Growth arrest-specific homeobox(gene name synonym)|uniprotkb:MEOX2(gene name)|psi-mi:MEOX2(display_short)|uniprotkb:GAX(gene name synonym)|uniprotkb:MOX2(gene name synonym) psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547739|imex:IM-13585-147 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106511(gene)|ensembl:ENST00000262041(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008015"(blood circulation)|go:"GO:0016607"(nuclear speck)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0061053"(somite development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR042634|refseq:NP_005915.2 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:fMv0ruKikzQ3MC0PBvJ3pOAjW+U9606 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 intact-crc:9F1BDEBE80AE418A|rigid:Gn5GOuTAT48Y63z56xBehNeipSw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P50222 uniprotkb:P03468 intact:EBI-748397|uniprotkb:O75263|ensembl:ENSP00000262041|uniprotkb:Q9UPL6|uniprotkb:B2R8I7|intact:EBI-10172134|intact:EBI-11522964|intact:EBI-11750003|intact:EBI-12702266|uniprotkb:A4D127 intact:EBI-2547744|uniprotkb:A4GXH6|uniprotkb:Q20N35|uniprotkb:Q84043|uniprotkb:Q8JUU4 psi-mi:meox2_human(display_long)|uniprotkb:Mesenchyme homeobox 2(gene name synonym)|uniprotkb:Growth arrest-specific homeobox(gene name synonym)|uniprotkb:MEOX2(gene name)|psi-mi:MEOX2(display_short)|uniprotkb:GAX(gene name synonym)|uniprotkb:MOX2(gene name synonym) psi-mi:nram_i34a1(display_long)|uniprotkb:NA(gene name)|psi-mi:NA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547766|imex:IM-13585-89 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106511(gene)|ensembl:ENST00000262041(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008015"(blood circulation)|go:"GO:0016607"(nuclear speck)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0061053"(somite development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR042634|refseq:NP_005915.2 go:"GO:0000139"(Golgi membrane)|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0046730"(induction by virus of host immune response)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:0055036"(virion membrane)|refseq:NP_040981.1|interpro:IPR001860(Glycoside hydrolase, family 34)|interpro:IPR033654|reactome:R-HSA-168275|reactome:R-HSA-168277|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-168255|interpro:IPR036278|rcsb pdb:6WZY|rcsb pdb:6X00 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:fMv0ruKikzQ3MC0PBvJ3pOAjW+U9606 rogid:YVcAxjIk6bzrYuQKio0NfZB9PG4211044 intact-crc:3FE5936161F9B6BC|rigid:vCR2kdrmAZsqVTDNMbCCjxlzbIk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:P50222 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-748397|uniprotkb:O75263|ensembl:ENSP00000262041|uniprotkb:Q9UPL6|uniprotkb:B2R8I7|intact:EBI-10172134|intact:EBI-11522964|intact:EBI-11750003|intact:EBI-12702266|uniprotkb:A4D127 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:meox2_human(display_long)|uniprotkb:Mesenchyme homeobox 2(gene name synonym)|uniprotkb:Growth arrest-specific homeobox(gene name synonym)|uniprotkb:MEOX2(gene name)|psi-mi:MEOX2(display_short)|uniprotkb:GAX(gene name synonym)|uniprotkb:MOX2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547771|imex:IM-13585-150 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 ensembl:ENSG00000106511(gene)|ensembl:ENST00000262041(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008015"(blood circulation)|go:"GO:0016607"(nuclear speck)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0061053"(somite development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR042634|refseq:NP_005915.2 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:fMv0ruKikzQ3MC0PBvJ3pOAjW+U9606 intact-crc:FB2D284264D60FEB|rigid:C8PahVsswLYiMDjuo56/2ec7RfQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13126 uniprotkb:P03466 intact:EBI-2547776|ensembl:ENSP00000494373|uniprotkb:Q5T3P3|uniprotkb:Q9H010|uniprotkb:I2G7M5|uniprotkb:I2G7M6|uniprotkb:I2G7M7|uniprotkb:I2G7M8|uniprotkb:I2G7M9|uniprotkb:I2G7N0 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:mtap_human(display_long)|uniprotkb:MTAP(gene name)|psi-mi:MTAP(display_short)|uniprotkb:MSAP(gene name synonym)|uniprotkb:5'-methylthioadenosine phosphorylase(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547800|imex:IM-13585-85 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000099810(gene)|ensembl:ENST00000644715(transcript)|go:"GO:0004645"(1,4-alpha-oligoglucan phosphorylase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0017061"(S-methyl-5-thioadenosine phosphorylase activity)|go:"GO:0019509"(L-methionine salvage from methylthioadenosine)|go:"GO:0032259"(methylation)|go:"GO:0033574"(response to testosterone)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:5EUB|rcsb pdb:5TC5|rcsb pdb:5TC6|rcsb pdb:5TC7|rcsb pdb:5TC8|rcsb pdb:6DYZ|rcsb pdb:6DZ0|rcsb pdb:6DZ2|rcsb pdb:6DZ3|reactome:R-HSA-1237112|reactome:R-HSA-8950505|interpro:IPR000845(Nucleoside phosphorylase)|interpro:IPR010044(Methylthioadenosine phosphorylase)|interpro:IPR018099|interpro:IPR035994|mint:Q13126|rcsb pdb:1CB0|rcsb pdb:1CG6|rcsb pdb:1K27|rcsb pdb:1SD1|rcsb pdb:1SD2|rcsb pdb:3LN5|rcsb pdb:3OZC|rcsb pdb:3OZD|rcsb pdb:3OZE|refseq:NP_002442.2 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:YQYb6o+mNKPtlSdUKveEOo7fpHE9606 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:17A9E74A3485EC66|rigid:j2YhrG4NI4pHkN4FIfLaDcN27eM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:O75489 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547805|imex:IM-13585-120 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 go:"GO:0019048"(modulation by virus of host process) - crc64:C058D62779BEF17B figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 intact-crc:C655DF5DF8A9008E|rigid:QENhXJXOu+PsoYW1JjA77sb31BY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q16656 uniprotkb:P03431 intact:EBI-2547810|ensembl:ENSP00000223190|ensembl:ENSP00000376922|ensembl:ENSP00000376924|uniprotkb:Q15305|uniprotkb:A8K4C6|uniprotkb:B4DDV6|uniprotkb:Q96AN2 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:nrf1_human(display_long)|uniprotkb:NRF1(gene name)|psi-mi:NRF1(display_short)|uniprotkb:Alpha palindromic-binding protein(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547836|imex:IM-13585-160 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106459(gene)|ensembl:ENST00000223190(transcript)|ensembl:ENST00000393230(transcript)|ensembl:ENST00000393232(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070062"(extracellular exosome)|interpro:IPR019525|interpro:IPR019526|interpro:IPR039142|reactome:R-HSA-1989781|reactome:R-HSA-2151201|go:"GO:0005634"(nucleus)|refseq:NP_001280092.1|refseq:NP_001280093.1|refseq:NP_001035199.1|refseq:NP_005002.3|dip:DIP-56958N go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:QvOptENwVbP2E1Z8ExTOmbx00NE9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:15F667E3021069F7|rigid:rvvM5Fa6syuwwLn+JiAYC/fF2SQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:Q13362 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-1266156|uniprotkb:B4DYJ8|uniprotkb:F5GWP3|uniprotkb:Q14391|uniprotkb:Q15060|uniprotkb:Q15174|uniprotkb:B5BUA5|intact:EBI-2556020|uniprotkb:Q6ZN33|ensembl:ENSP00000333905 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:2a5g_human(display_long)|uniprotkb:PPP2R5C(gene name)|psi-mi:PPP2R5C(display_short)|uniprotkb:KIAA0044(gene name synonym)|uniprotkb:PP2A B subunit isoform B'-gamma(gene name synonym)|uniprotkb:PP2A B subunit isoform B56-gamma(gene name synonym)|uniprotkb:PP2A B subunit isoform PR61-gamma(gene name synonym)|uniprotkb:PP2A B subunit isoform R5-gamma(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-29(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547841|imex:IM-13585-186 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 refseq:NP_002710.2|refseq:NP_848701.1|refseq:NP_848702.1|refseq:NP_001155197.1|refseq:NP_001155198.1|refseq:XP_011535222.1|refseq:XP_005267884.1|dip:DIP-39401N|ensembl:ENSG00000078304(gene)|ensembl:ENST00000334743(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0072542"(protein phosphatase activator activity)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q13362|rcsb pdb:2IAE|rcsb pdb:2JAK|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:3FGA|rcsb pdb:5JJA|rcsb pdb:5K6S|rcsb pdb:5SW9|rcsb pdb:5SWF|rcsb pdb:6OYL|rcsb pdb:6TOQ|rcsb pdb:6VOY|rcsb pdb:6VRO|rcsb pdb:6Z2Y|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-141444|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-9648025 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:vKPPLnEfyCzEZ2O5lrQDCRghiV09606 intact-crc:C53559EF7F0A9602|rigid:pT2muU3POV9I4LqsTALWl/XXlrg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:P45984 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-713568|uniprotkb:Q15708|uniprotkb:Q15710|uniprotkb:Q15711|uniprotkb:Q8N5C5|uniprotkb:A8K0S3|ensembl:ENSP00000394560|uniprotkb:B5M0B4|uniprotkb:B5BU66|uniprotkb:D3DWQ8|uniprotkb:D3DWQ9 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:mk09_human(display_long)|uniprotkb:Stress-activated protein kinase JNK2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 2(gene name synonym)|uniprotkb:JNK-55(gene name synonym)|uniprotkb:MAPK9(gene name)|psi-mi:MAPK9(display_short)|uniprotkb:JNK2(gene name synonym)|uniprotkb:PRKM9(gene name synonym)|uniprotkb:Stress-activated protein kinase 1a(gene name synonym)|uniprotkb:SAPK1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547846|imex:IM-13585-215 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:XP_006714954.1|refseq:NP_001128516.1|refseq:NP_002743.3|refseq:NP_620707.1|ensembl:ENSG00000050748(gene)|ensembl:ENST00000452135(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|refseq:NP_620708.1|refseq:NP_620709.1|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45984|rcsb pdb:3E7O|rcsb pdb:3NPC|rcsb pdb:7CML|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-450341|refseq:NP_001295173.1|dip:DIP-270N|refseq:XP_016865127.1|refseq:XP_016865130.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:ljhZd5mc0kj5al142zo5Me2J26w9606 intact-crc:E4B5F6042F4062A3|rigid:/pH+4Gkbt9a9MELikC4eoWNjfOU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P45984 uniprotkb:P03496 intact:EBI-713568|uniprotkb:Q15708|uniprotkb:Q15710|uniprotkb:Q15711|uniprotkb:Q8N5C5|uniprotkb:A8K0S3|ensembl:ENSP00000394560|uniprotkb:B5M0B4|uniprotkb:B5BU66|uniprotkb:D3DWQ8|uniprotkb:D3DWQ9 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:mk09_human(display_long)|uniprotkb:Stress-activated protein kinase JNK2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 2(gene name synonym)|uniprotkb:JNK-55(gene name synonym)|uniprotkb:MAPK9(gene name)|psi-mi:MAPK9(display_short)|uniprotkb:JNK2(gene name synonym)|uniprotkb:PRKM9(gene name synonym)|uniprotkb:Stress-activated protein kinase 1a(gene name synonym)|uniprotkb:SAPK1A(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547851|imex:IM-13585-153 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006714954.1|refseq:NP_001128516.1|refseq:NP_002743.3|refseq:NP_620707.1|ensembl:ENSG00000050748(gene)|ensembl:ENST00000452135(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|refseq:NP_620708.1|refseq:NP_620709.1|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45984|rcsb pdb:3E7O|rcsb pdb:3NPC|rcsb pdb:7CML|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-450341|refseq:NP_001295173.1|dip:DIP-270N|refseq:XP_016865127.1|refseq:XP_016865130.1 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:ljhZd5mc0kj5al142zo5Me2J26w9606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:1FE2079681D47186|rigid:sZUP3PcVKohlF5UIeq2zxeyLk7w false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q99942 uniprotkb:P03433 intact:EBI-348482|ensembl:ENSP00000364235|ensembl:ENSP00000387879|ensembl:ENSP00000388795|ensembl:ENSP00000401172|ensembl:ENSP00000413131|ensembl:ENSP00000415127|ensembl:ENSP00000415784|uniprotkb:A2BFI6|uniprotkb:Q0VDB7|uniprotkb:Q9UMQ2|uniprotkb:B2R4K3 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:rnf5_human(display_long)|uniprotkb:RNF5(gene name)|psi-mi:RNF5(display_short)|uniprotkb:G16(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:NG2(gene name synonym)|uniprotkb:RMA1(gene name synonym)|uniprotkb:Ram1 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547856|imex:IM-13585-232 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008844.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|ensembl:ENST00000456167(transcript)|ensembl:ENSG00000183574(gene)|ensembl:ENSG00000204308(gene)|ensembl:ENSG00000223767(gene)|ensembl:ENSG00000225452(gene)|ensembl:ENSG00000227277(gene)|ensembl:ENSG00000228405(gene)|ensembl:ENSG00000228907(gene)|ensembl:ENST00000375094(transcript)|ensembl:ENST00000413786(transcript)|ensembl:ENST00000432616(transcript)|ensembl:ENST00000445885(transcript)|ensembl:ENST00000449794(transcript)|ensembl:ENST00000453473(transcript)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032|go:"GO:0044877"(protein-containing complex binding)|dip:DIP-29268N go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:eHlCD+xbWmpzFdhVn6OC5MPqeNE9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:8E0B695475FE4AA2|rigid:qrD4si+bbTRPcUgc1dL5pV/0oXY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8IUQ4 uniprotkb:P03431 intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547861|imex:IM-13585-154 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:0A21E170588441E2|rigid:94sWtMpIILu8NL2QdvyLuKm1ugU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:P23497 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-751145|uniprotkb:E9PH61|uniprotkb:O75450|uniprotkb:Q13343|uniprotkb:Q96F70|uniprotkb:Q96T24|uniprotkb:Q96T95|uniprotkb:Q9NP33|uniprotkb:Q9UE32|uniprotkb:Q8TE34|ensembl:ENSP00000264052|uniprotkb:B4DDX5|uniprotkb:B8ZZD8|uniprotkb:F8WFE2|uniprotkb:E7EUA7 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:sp100_human(display_long)|uniprotkb:Nuclear dot-associated Sp100 protein(gene name synonym)|uniprotkb:Speckled 100 kDa(gene name synonym)|uniprotkb:SP100(gene name)|psi-mi:SP100(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547866|imex:IM-13585-172 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 refseq:NP_001073860.1|refseq:NP_001193630.1|refseq:NP_001193631.1|refseq:NP_001193632.1|refseq:NP_001193633.1|refseq:NP_003104.2|ensembl:ENSG00000067066(gene)|ensembl:ENST00000264052(transcript)|dip:DIP-5983N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034097"(response to cytokine)|go:"GO:0034340"(response to type I interferon)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902044"(regulation of Fas signaling pathway)|interpro:IPR000770(SAND)|interpro:IPR004865(Sp100)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR010919(SAND-like)|interpro:IPR036910|interpro:IPR043563|mint:P23497|rcsb pdb:1H5P|rcsb pdb:4PTB|rcsb pdb:5FB0|rcsb pdb:5FB1|rcsb pdb:5PWE|rcsb pdb:5PWF|rcsb pdb:5PWG|rcsb pdb:5PWH|rcsb pdb:5PWI|rcsb pdb:5PWJ|rcsb pdb:5PWK|rcsb pdb:5PWL|rcsb pdb:5PWM|rcsb pdb:5PWN|rcsb pdb:5PWO|rcsb pdb:5PWP|rcsb pdb:5PWQ|rcsb pdb:5PWR|rcsb pdb:5PWS|rcsb pdb:5PWT|rcsb pdb:5PWU|rcsb pdb:5PWV|rcsb pdb:5PWW|rcsb pdb:5PWX|rcsb pdb:5PWY|rcsb pdb:5PWZ|rcsb pdb:5PX0|rcsb pdb:5PX1|rcsb pdb:5PX2|rcsb pdb:5PX3|rcsb pdb:5PX4|rcsb pdb:5PX5|rcsb pdb:5PX6|rcsb pdb:5PX7|rcsb pdb:5PX8|rcsb pdb:5PX9|rcsb pdb:5PXA|rcsb pdb:5PXB|rcsb pdb:5PXC|rcsb pdb:5PXD|rcsb pdb:5PXE|rcsb pdb:5PXF|rcsb pdb:5PXG|rcsb pdb:5PXH|rcsb pdb:5PXI|rcsb pdb:5PXJ|rcsb pdb:5PXK|rcsb pdb:5PXL|rcsb pdb:5PXM|rcsb pdb:5PXN|rcsb pdb:5PXO|rcsb pdb:5PXP|rcsb pdb:5PXQ|rcsb pdb:5PXR|rcsb pdb:5PXS|rcsb pdb:5PXT|rcsb pdb:5PXU|rcsb pdb:5PXV|rcsb pdb:5PXW|rcsb pdb:5PXX|rcsb pdb:5PXY|rcsb pdb:5PXZ|rcsb pdb:5PY0|rcsb pdb:5PY1|rcsb pdb:5PY2|rcsb pdb:5PY3|rcsb pdb:5PY4|rcsb pdb:5PY5|rcsb pdb:5PY6|rcsb pdb:5PY7|rcsb pdb:5PY8|rcsb pdb:5PY9|rcsb pdb:5PYA|rcsb pdb:5PYB|rcsb pdb:5PYC|rcsb pdb:5PYD|rcsb pdb:5PYE|rcsb pdb:5PYF|rcsb pdb:5PYG|rcsb pdb:5PYH|rcsb pdb:5PYI|rcsb pdb:5PYJ|rcsb pdb:5PYK|rcsb pdb:5PYL|rcsb pdb:5PYM|rcsb pdb:5PYN|rcsb pdb:5PYO|rcsb pdb:5PYP|rcsb pdb:5PYQ|rcsb pdb:5PYR|rcsb pdb:5PYS|rcsb pdb:5PYT|rcsb pdb:5PYU|rcsb pdb:5PYV|rcsb pdb:5PYW|rcsb pdb:5PYX|rcsb pdb:5PYY|rcsb pdb:5PYZ|rcsb pdb:5PZ0|rcsb pdb:5PZ1|rcsb pdb:5PZ2|rcsb pdb:5PZ3|rcsb pdb:5PZ4|rcsb pdb:5PZ5|rcsb pdb:5PZ6|rcsb pdb:5PZ7|rcsb pdb:5PZ8|rcsb pdb:5PZ9|rcsb pdb:5PZA|rcsb pdb:5PZB|rcsb pdb:5PZC|rcsb pdb:5PZD|rcsb pdb:5PZF|rcsb pdb:5PZG|rcsb pdb:5PZH|rcsb pdb:5PZI|rcsb pdb:5PZJ|rcsb pdb:6G5N|rcsb pdb:6G5P|reactome:R-HSA-3108214|reactome:R-HSA-877300|rcsb pdb:5PZE go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:+rzb0oseufnoLe2QXNCvZlV89x89606 intact-crc:814926F9857BC659|rigid:/veNHXbrSwI0g0dTl4lee4zHEPA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03485 uniprotkb:O95793 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 intact:EBI-358174|uniprotkb:Q6GTM4|uniprotkb:Q9H5B5|intact:EBI-366174|uniprotkb:Q9H5B4|uniprotkb:Q9Y3Q2|uniprotkb:A8K9Z4|ensembl:ENSP00000360922|uniprotkb:E1P5Y1|uniprotkb:E1P608|uniprotkb:Q5JW29 psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:stau1_human(display_long)|uniprotkb:STAU1(gene name)|psi-mi:STAU1(display_short)|uniprotkb:STAU(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547871|imex:IM-13585-124 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 refseq:NP_001309856.1|refseq:NP_001309858.1|refseq:NP_001309859.1|refseq:NP_001032405.1|refseq:NP_004593.2|refseq:NP_059346.2|refseq:NP_059347.2|refseq:NP_059348.2|refseq:NP_001306063.1|refseq:NP_001306064.1|ensembl:ENSG00000124214(gene)|ensembl:ENST00000371856(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|refseq:XP_005260584.1|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044475|mint:O95793|rcsb pdb:4DKK|rcsb pdb:6HTU|rcsb pdb:6SDW|rcsb pdb:6SDY go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 rogid:uYjbWja/hG5M/3likHLe00Z2FgY9606 intact-crc:5D6F12B9BA6A5133|rigid:dXea5jhAbd1t6OJxMxf5m9AS80c false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O95793 uniprotkb:P03496 intact:EBI-358174|uniprotkb:Q6GTM4|uniprotkb:Q9H5B5|intact:EBI-366174|uniprotkb:Q9H5B4|uniprotkb:Q9Y3Q2|uniprotkb:A8K9Z4|ensembl:ENSP00000360922|uniprotkb:E1P5Y1|uniprotkb:E1P608|uniprotkb:Q5JW29 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:stau1_human(display_long)|uniprotkb:STAU1(gene name)|psi-mi:STAU1(display_short)|uniprotkb:STAU(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547876|imex:IM-13585-168 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309856.1|refseq:NP_001309858.1|refseq:NP_001309859.1|refseq:NP_001032405.1|refseq:NP_004593.2|refseq:NP_059346.2|refseq:NP_059347.2|refseq:NP_059348.2|refseq:NP_001306063.1|refseq:NP_001306064.1|ensembl:ENSG00000124214(gene)|ensembl:ENST00000371856(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|refseq:XP_005260584.1|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044475|mint:O95793|rcsb pdb:4DKK|rcsb pdb:6HTU|rcsb pdb:6SDW|rcsb pdb:6SDY go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:uYjbWja/hG5M/3likHLe00Z2FgY9606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:A2085ED199F62FC6|rigid:hIFeVYbOjqxzNnNXcwxzpIBy1gU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:Q13190 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-714206|uniprotkb:Q5U0D4|uniprotkb:Q7Z3T6|uniprotkb:Q9BUG1|uniprotkb:B2R8T2|ensembl:ENSP00000294179|uniprotkb:F8W8Q9 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:stx5_human(display_long)|uniprotkb:STX5(gene name)|psi-mi:STX5(display_short)|uniprotkb:STX5A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547881|imex:IM-13585-195 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 refseq:NP_003155.2|ensembl:ENSG00000162236(gene)|ensembl:ENST00000294179(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031982"(vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045296"(cadherin binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0090166"(Golgi disassembly)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR021538|mint:Q13190|rcsb pdb:3EFO|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-8980692|reactome:R-HSA-9013106|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|reactome:R-HSA-9013408|reactome:R-HSA-9609523|refseq:NP_001231595.1|refseq:NP_001317223.1|dip:DIP-56987N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:cR4cS695ZWQQ5Bkim9HqmCE0hCE9606 intact-crc:99955E3657DC86D6|rigid:h5bf0b+7NNPzYEberl2BmGnfTTo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:O75410 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-624237|uniprotkb:Q8IUJ3|uniprotkb:Q8IUJ4|uniprotkb:Q8IZG2|uniprotkb:Q8NEY7|uniprotkb:Q9UPP9|uniprotkb:B2RBD9|uniprotkb:Q6Y687|uniprotkb:Q86YG7|uniprotkb:Q8IUJ2|ensembl:ENSP00000321703|uniprotkb:D3DSX6|uniprotkb:B4E302 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:tacc1_human(display_long)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547896|imex:IM-13585-157 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 ensembl:ENSG00000147526(gene)|ensembl:ENST00000317827(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0051301"(cell division)|interpro:IPR007707(Transforming acidic coiled-coil-containing)|interpro:IPR039915|mint:O75410|go:"GO:0046966"(thyroid hormone receptor binding)|refseq:NP_001116296.1|refseq:NP_001139688.1|refseq:NP_006274.2|refseq:XP_005273682.1|refseq:XP_011542933.1|refseq:XP_011542934.1|refseq:XP_011542938.1|refseq:XP_016869261.1|refseq:XP_016869262.1|refseq:XP_016869263.1|refseq:XP_011542936.1|refseq:XP_011542939.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:o/GBmp6rt7B1GgH4gdBNaN5VrSc9606 intact-crc:7E471E79F7B2B04C|rigid:lPPumcBYMIbrMoh+Df4PYd6r8JA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:Q15633 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-978581|uniprotkb:Q12878|ensembl:ENSP00000266987|uniprotkb:Q9BRY2|uniprotkb:Q8WY32|uniprotkb:Q8WY33 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:trbp2_human(display_long)|uniprotkb:Trans-activation-responsive RNA-binding protein(gene name synonym)|uniprotkb:TARBP2(gene name)|psi-mi:TARBP2(display_short)|uniprotkb:TRBP(gene name synonym)|uniprotkb:TAR RNA-binding protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547901|imex:IM-13585-158 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 ensembl:ENSG00000139546(gene)|ensembl:ENST00000266987(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0016442"(RISC complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050689"(negative regulation of defense response to virus by host)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090065"(regulation of production of siRNA involved in RNA interference)|go:"GO:1903798"(regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR028605|interpro:IPR044469|interpro:IPR044470|interpro:IPR044471|mint:Q15633|rcsb pdb:2CPN|rcsb pdb:3ADL|rcsb pdb:3LLH|rcsb pdb:4WYQ|go:"GO:0016604"(nuclear body)|rcsb pdb:5N8L|rcsb pdb:5N8M|rcsb pdb:5ZAK|rcsb pdb:5ZAL|rcsb pdb:5ZAM|rcsb pdb:6ZBK|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_004169.3|refseq:NP_599150.1|refseq:NP_599151.2|refseq:XP_005269171.1|refseq:XP_005269172.1|dip:DIP-29665N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:2pOFQwyM408mDl2bYsKEb1yhFrE9606 intact-crc:B51124D3CA6DA834|rigid:6ZewR3O0MDTf2XcrkRBbSvnq6Og false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:Q99081 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-722877|uniprotkb:Q86VM2|ensembl:ENSP00000267811|ensembl:ENSP00000453737|uniprotkb:Q7Z3D9|uniprotkb:Q86TC1|uniprotkb:B4E1W1 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:htf4_human(display_long)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:TCF12(gene name)|psi-mi:TCF12(display_short)|uniprotkb:HEB(gene name synonym)|uniprotkb:HTF4(gene name synonym)|uniprotkb:BHLHB20(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547908|imex:IM-13585-235 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 refseq:NP_001309086.1|refseq:NP_003196.1|refseq:NP_996919.1|refseq:NP_996920.1|refseq:NP_996921.1|refseq:NP_996923.1|ensembl:ENSG00000140262(gene)|ensembl:ENST00000267811(transcript)|ensembl:ENST00000557843(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|refseq:NP_001309080.1|refseq:NP_001293149.1|refseq:NP_001309088.1|refseq:NP_001309091.1|refseq:NP_001309094.1|dip:DIP-29403N|mint:Q99081|rcsb pdb:2KNH|rcsb pdb:4JOL|reactome:R-HSA-525793|reactome:R-HSA-8939236|reactome:R-HSA-9031628 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:XnBrmDaoz2JZQ66PCjfJsmaQ6209606 intact-crc:8B6A919CBDE2BB7A|rigid:c1FPW1gpNBKNQ2WxIxR/WCgnXbI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q99081 uniprotkb:P03428 intact:EBI-722877|uniprotkb:Q86VM2|ensembl:ENSP00000267811|ensembl:ENSP00000453737|uniprotkb:Q7Z3D9|uniprotkb:Q86TC1|uniprotkb:B4E1W1 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:htf4_human(display_long)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:TCF12(gene name)|psi-mi:TCF12(display_short)|uniprotkb:HEB(gene name synonym)|uniprotkb:HTF4(gene name synonym)|uniprotkb:BHLHB20(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 20(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547913|imex:IM-13585-159 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309086.1|refseq:NP_003196.1|refseq:NP_996919.1|refseq:NP_996920.1|refseq:NP_996921.1|refseq:NP_996923.1|ensembl:ENSG00000140262(gene)|ensembl:ENST00000267811(transcript)|ensembl:ENST00000557843(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|refseq:NP_001309080.1|refseq:NP_001293149.1|refseq:NP_001309088.1|refseq:NP_001309091.1|refseq:NP_001309094.1|dip:DIP-29403N|mint:Q99081|rcsb pdb:2KNH|rcsb pdb:4JOL|reactome:R-HSA-525793|reactome:R-HSA-8939236|reactome:R-HSA-9031628 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:XnBrmDaoz2JZQ66PCjfJsmaQ6209606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:8D00319F6835AFE1|rigid:QznCCzmZ+YftXfhRNs6UJE1hmXg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q12800 uniprotkb:P03431 intact:EBI-717422|uniprotkb:Q12801|uniprotkb:Q9UD77|uniprotkb:A8K5E9|uniprotkb:Q9UD75|ensembl:ENSP00000257915 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:tfcp2_human(display_long)|uniprotkb:Transcription factor LSF(gene name synonym)|uniprotkb:SAA3 enhancer factor(gene name synonym)|uniprotkb:TFCP2(gene name)|psi-mi:TFCP2(display_short)|uniprotkb:LSF(gene name synonym)|uniprotkb:SEF(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547918|imex:IM-13585-148 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001166923.1|refseq:NP_001166924.1|refseq:NP_005644.2|ensembl:ENSG00000135457(gene)|ensembl:ENST00000257915(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037599|interpro:IPR041418|mint:Q12800 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:M7mQ08NDYxuawmUEKRgjSdIr+Og9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:40891DFDC5F14365|rigid:yaHVRAi+Y0NT5CsSkidaDbHY6GI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q12800 uniprotkb:P03485 intact:EBI-717422|uniprotkb:Q12801|uniprotkb:Q9UD77|uniprotkb:A8K5E9|uniprotkb:Q9UD75|ensembl:ENSP00000257915 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:tfcp2_human(display_long)|uniprotkb:Transcription factor LSF(gene name synonym)|uniprotkb:SAA3 enhancer factor(gene name synonym)|uniprotkb:TFCP2(gene name)|psi-mi:TFCP2(display_short)|uniprotkb:LSF(gene name synonym)|uniprotkb:SEF(gene name synonym) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547923|imex:IM-13585-161 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001166923.1|refseq:NP_001166924.1|refseq:NP_005644.2|ensembl:ENSG00000135457(gene)|ensembl:ENST00000257915(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037599|interpro:IPR041418|mint:Q12800 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:M7mQ08NDYxuawmUEKRgjSdIr+Og9606 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:FEF53BE7A3CB54A1|rigid:J4TfS/axR/kKONWVTVVMiJPMZTA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q12800 uniprotkb:P06821 intact:EBI-717422|uniprotkb:Q12801|uniprotkb:Q9UD77|uniprotkb:A8K5E9|uniprotkb:Q9UD75|ensembl:ENSP00000257915 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 psi-mi:tfcp2_human(display_long)|uniprotkb:Transcription factor LSF(gene name synonym)|uniprotkb:SAA3 enhancer factor(gene name synonym)|uniprotkb:TFCP2(gene name)|psi-mi:TFCP2(display_short)|uniprotkb:LSF(gene name synonym)|uniprotkb:SEF(gene name synonym) psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547928|imex:IM-13585-156 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001166923.1|refseq:NP_001166924.1|refseq:NP_005644.2|ensembl:ENSG00000135457(gene)|ensembl:ENST00000257915(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037599|interpro:IPR041418|mint:Q12800 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:M7mQ08NDYxuawmUEKRgjSdIr+Og9606 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 intact-crc:22D54B02F45E199F|rigid:T4Q4cTFfhcU60hcY9iTWQal4gik false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q12800 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-717422|uniprotkb:Q12801|uniprotkb:Q9UD77|uniprotkb:A8K5E9|uniprotkb:Q9UD75|ensembl:ENSP00000257915 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:tfcp2_human(display_long)|uniprotkb:Transcription factor LSF(gene name synonym)|uniprotkb:SAA3 enhancer factor(gene name synonym)|uniprotkb:TFCP2(gene name)|psi-mi:TFCP2(display_short)|uniprotkb:LSF(gene name synonym)|uniprotkb:SEF(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547933|imex:IM-13585-162 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:NP_001166923.1|refseq:NP_001166924.1|refseq:NP_005644.2|ensembl:ENSG00000135457(gene)|ensembl:ENST00000257915(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037599|interpro:IPR041418|mint:Q12800 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:M7mQ08NDYxuawmUEKRgjSdIr+Og9606 intact-crc:46E3BDFE102657FE|rigid:DadSP2bCXrQ7NW0aMrKwk/+aiQs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q13077 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-359224|uniprotkb:Q658U1|uniprotkb:Q8NF13|uniprotkb:B4DJ77|ensembl:ENSP00000362994|ensembl:ENSP00000443183 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:traf1_human(display_long)|uniprotkb:TRAF1(gene name)|psi-mi:TRAF1(display_short)|uniprotkb:EBI6(gene name synonym)|uniprotkb:Epstein-Barr virus-induced protein 6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547938|imex:IM-13585-115 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:NP_001177874.1|refseq:NP_001177876.1|refseq:NP_005649.1|dip:DIP-27514N|ensembl:ENSG00000056558(gene)|ensembl:ENST00000373887(transcript)|ensembl:ENST00000540010(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|mint:Q13077|rcsb pdb:3M0D|rcsb pdb:5E1T|rcsb pdb:5H10|reactome:R-HSA-5357905|reactome:R-HSA-5357956 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:D51RV1gTNQQjGP978+uv98Hd3Lc9606 intact-crc:E4916072C67A2B05|rigid:QVviZSODfuQaa7/iSeN1o8WvLZ4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13077 uniprotkb:P03466 intact:EBI-359224|uniprotkb:Q658U1|uniprotkb:Q8NF13|uniprotkb:B4DJ77|ensembl:ENSP00000362994|ensembl:ENSP00000443183 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:traf1_human(display_long)|uniprotkb:TRAF1(gene name)|psi-mi:TRAF1(display_short)|uniprotkb:EBI6(gene name synonym)|uniprotkb:Epstein-Barr virus-induced protein 6(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547943|imex:IM-13585-244 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001177874.1|refseq:NP_001177876.1|refseq:NP_005649.1|dip:DIP-27514N|ensembl:ENSG00000056558(gene)|ensembl:ENST00000373887(transcript)|ensembl:ENST00000540010(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|mint:Q13077|rcsb pdb:3M0D|rcsb pdb:5E1T|rcsb pdb:5H10|reactome:R-HSA-5357905|reactome:R-HSA-5357956 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:D51RV1gTNQQjGP978+uv98Hd3Lc9606 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:DDC92FDC2442C126|rigid:YzquRJWKhfloCQy0qWXU9IoPeGk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q12933 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547949|imex:IM-13585-163 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606 intact-crc:275E87113AA7D480|rigid:G2m0Vwh61NcPKGXALyA1GGnP1Ik false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:Q15654 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-742327|uniprotkb:O15170|uniprotkb:O15275|uniprotkb:Q9BTB2|uniprotkb:Q9BUE5|uniprotkb:Q9BXP3|uniprotkb:Q9UNT4|uniprotkb:A4D2E7|ensembl:ENSP00000200457|uniprotkb:F2ZC07|uniprotkb:F2ZC08 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:trip6_human(display_long)|uniprotkb:TRIP6(gene name)|psi-mi:TRIP6(display_short)|uniprotkb:OIP1(gene name synonym)|uniprotkb:Opa-interacting protein 1(gene name synonym)|uniprotkb:Zyxin-related protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547954|imex:IM-13585-176 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 refseq:NP_003293.2|ensembl:ENSP00000200457|ensembl:ENST00000417475|ensembl:ENSP00000413817|ensembl:ENST00000437505|ensembl:ENSP00000410736|ensembl:ENST00000619988|ensembl:ENSP00000479865|ensembl:ENSG00000087077(gene)|ensembl:ENST00000200457(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q15654|rcsb pdb:1X61|rcsb pdb:2DLO|dip:DIP-34466N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:9Okf3b6sMMwX5awAx991GN9iSsQ9606 intact-crc:52A761DE4C8E20B5|rigid:z2bRCs2BhzdJATUiLzRysc4Tg50 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P63279 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-80168|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q59GX1|uniprotkb:Q86VB3|ensembl:ENSP00000324897|ensembl:ENSP00000348056|ensembl:ENSP00000380649|ensembl:ENSP00000380650|ensembl:ENSP00000384568|ensembl:ENSP00000455893|ensembl:ENSP00000456188|ensembl:ENSP00000457064|ensembl:ENSP00000490882|ensembl:ENSP00000385009|uniprotkb:D3DU69 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:ubc9_human(display_long)|uniprotkb:UBE2I(gene name)|psi-mi:UBE2I(display_short)|uniprotkb:p18(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:UBC9(gene name synonym)|uniprotkb:UBCE9(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547959|imex:IM-13585-178 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 refseq:NP_003336.1|refseq:NP_919235.1|refseq:NP_919236.1|refseq:NP_919237.1|ensembl:ENSG00000103275(gene)|rcsb pdb:5D2M|rcsb pdb:5F6D|rcsb pdb:5F6E|rcsb pdb:5F6U|rcsb pdb:5F6V|rcsb pdb:5F6W|rcsb pdb:5F6X|rcsb pdb:5F6Y|rcsb pdb:5FQ2|rcsb pdb:6SYF|reactome:R-HSA-1221632|reactome:R-HSA-196791|reactome:R-HSA-3065678|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000325437(transcript)|ensembl:ENST00000355803(transcript)|ensembl:ENST00000397514(transcript)|ensembl:ENST00000397515(transcript)|ensembl:ENST00000403747(transcript)|ensembl:ENST00000406620(transcript)|ensembl:ENST00000562470(transcript)|ensembl:ENST00000566587(transcript)|ensembl:ENST00000567074(transcript)|ensembl:ENST00000567383(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63279|rcsb pdb:1A3S|rcsb pdb:1KPS|rcsb pdb:1Z5Q|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2O25|rcsb pdb:2PE6|rcsb pdb:2PX9|rcsb pdb:2XWU|rcsb pdb:3A4S|rcsb pdb:3UIN|go:"GO:1990234"(transferase complex)|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4W5V|rcsb pdb:4Y1L|refseq:XP_016879129.1|dip:DIP-29078N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo9606 intact-crc:F9053A622804B4B3|rigid:oNiFns3lTaoG1ZlAsA1fakpDGlw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P63279 uniprotkb:P03496 intact:EBI-80168|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q59GX1|uniprotkb:Q86VB3|ensembl:ENSP00000324897|ensembl:ENSP00000348056|ensembl:ENSP00000380649|ensembl:ENSP00000380650|ensembl:ENSP00000384568|ensembl:ENSP00000455893|ensembl:ENSP00000456188|ensembl:ENSP00000457064|ensembl:ENSP00000490882|ensembl:ENSP00000385009|uniprotkb:D3DU69 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:ubc9_human(display_long)|uniprotkb:UBE2I(gene name)|psi-mi:UBE2I(display_short)|uniprotkb:p18(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:UBC9(gene name synonym)|uniprotkb:UBCE9(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547964|imex:IM-13585-189 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003336.1|refseq:NP_919235.1|refseq:NP_919236.1|refseq:NP_919237.1|ensembl:ENSG00000103275(gene)|rcsb pdb:5D2M|rcsb pdb:5F6D|rcsb pdb:5F6E|rcsb pdb:5F6U|rcsb pdb:5F6V|rcsb pdb:5F6W|rcsb pdb:5F6X|rcsb pdb:5F6Y|rcsb pdb:5FQ2|rcsb pdb:6SYF|reactome:R-HSA-1221632|reactome:R-HSA-196791|reactome:R-HSA-3065678|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000325437(transcript)|ensembl:ENST00000355803(transcript)|ensembl:ENST00000397514(transcript)|ensembl:ENST00000397515(transcript)|ensembl:ENST00000403747(transcript)|ensembl:ENST00000406620(transcript)|ensembl:ENST00000562470(transcript)|ensembl:ENST00000566587(transcript)|ensembl:ENST00000567074(transcript)|ensembl:ENST00000567383(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63279|rcsb pdb:1A3S|rcsb pdb:1KPS|rcsb pdb:1Z5Q|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2O25|rcsb pdb:2PE6|rcsb pdb:2PX9|rcsb pdb:2XWU|rcsb pdb:3A4S|rcsb pdb:3UIN|go:"GO:1990234"(transferase complex)|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4W5V|rcsb pdb:4Y1L|refseq:XP_016879129.1|dip:DIP-29078N go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo9606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:04386BF35347B30D|rigid:jfN9gqwz2PshsMEe3TKm8oHvnwI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P10746 uniprotkb:P03433 intact:EBI-947201|uniprotkb:Q9H2T1|uniprotkb:B2RC13|uniprotkb:D3DRF7|ensembl:ENSP00000357775|ensembl:ENSP00000357787 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:hem4_human(display_long)|uniprotkb:UROS(gene name)|psi-mi:UROS(display_short)|uniprotkb:Hydroxymethylbilane hydrolyase [cyclizing](gene name synonym)|uniprotkb:Uroporphyrinogen-III cosynthase(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547969|imex:IM-13585-219 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000366.1|ensembl:ENSG00000188690(gene)|ensembl:ENST00000368786(transcript)|ensembl:ENST00000368797(transcript)|go:"GO:0004852"(uroporphyrinogen-III synthase activity)|go:"GO:0005542"(folic acid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006780"(uroporphyrinogen III biosynthetic process)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071418"(cellular response to amine stimulus)|interpro:IPR003754(Tetrapyrrole biosynthesis, uroporphyrinogen III synthase)|interpro:IPR036108|interpro:IPR039793|rcsb pdb:1JR2|reactome:R-HSA-189451 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:FdHKcxUZ+y33x6DVHZJR6SbCXIg9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:3EFEE86B2B7DCAE7|rigid:W5hoBkO5xdpvtz6Y3u8FpsZtTUQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06821 uniprotkb:P24278 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 intact:EBI-739899|uniprotkb:Q8IYH9|uniprotkb:B3KUX6|ensembl:ENSP00000378204|ensembl:ENSP00000476746 psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:zbt25_human(display_long)|uniprotkb:ZBTB25(gene name)|psi-mi:ZBTB25(display_short)|uniprotkb:KUP(gene name synonym)|uniprotkb:ZNF46(gene name synonym)|uniprotkb:Zinc finger protein 46(gene name synonym)|uniprotkb:Zinc finger protein KUP(gene name synonym)|uniprotkb:C14orf51(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2547974|imex:IM-13585-226 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 refseq:NP_008908.2|ensembl:ENSG00000089775(gene)|ensembl:ENST00000394715(transcript)|ensembl:ENST00000608382(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P24278|refseq:NP_001291436.1|refseq:XP_011535445.1|refseq:XP_006720314.1|refseq:XP_006720315.1|refseq:XP_016877121.1|refseq:XP_016877122.1|refseq:XP_016877123.1|refseq:XP_016877124.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 rogid:xi3bM5CoeXvVZNBOzaQlZdWU4ag9606 intact-crc:6A6F4F9606FD1176|rigid:+qWAgvXL8ZRH3ZTPDB1jNrocx/g false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13155 uniprotkb:P03508 intact:EBI-745226|uniprotkb:Q75MR1|uniprotkb:Q96CZ5|uniprotkb:Q9P1L2|ensembl:ENSP00000223029|uniprotkb:F8W950 intact:EBI-2547979|uniprotkb:A4GXG8|uniprotkb:Q20N33|uniprotkb:Q67266|uniprotkb:Q71QT4 psi-mi:aimp2_human(display_long)|uniprotkb:Protein JTV-1(gene name synonym)|uniprotkb:AIMP2(gene name)|psi-mi:AIMP2(display_short)|uniprotkb:PRO0992(orf name)|uniprotkb:JTV1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p38(gene name synonym) psi-mi:nep_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548007|imex:IM-13585-242 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006294.2|ensembl:ENSG00000106305(gene)|ensembl:ENST00000223029(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903632"(positive regulation of aminoacyl-tRNA ligase activity)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR031889|interpro:IPR036282|interpro:IPR041503|interpro:IPR042360|mint:Q13155|rcsb pdb:4DPG|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5Y6L|rcsb pdb:6ILD|rcsb pdb:6IY6|rcsb pdb:6JPV|rcsb pdb:6K39|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-34421N|refseq:NP_001313536.1 go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)")|refseq:NP_040983.1|rcsb pdb:1PD3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VEBmJjo6t3dBY6mKpmUyVLamJFQ9606 rogid:xFUkgB+T3wkm4nwM67KuSUj1gP0211044 intact-crc:1AF9EF88F9F2ABCB|rigid:PPZEUhn5ftOiIPlostvUf5x/5SU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q9H2G9 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-2548012|intact:EBI-28986503|ensembl:ENSP00000327541|ensembl:ENSP00000356782|uniprotkb:O15298|uniprotkb:Q5T531|uniprotkb:Q5T533|uniprotkb:Q9GZX4 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:go45_human(display_long)|uniprotkb:BLZF1(gene name)|psi-mi:BLZF1(display_short)|uniprotkb:JEM1(gene name synonym)|uniprotkb:Basic leucine zipper nuclear factor 1(gene name synonym)|uniprotkb:JEM-1(gene name synonym)|uniprotkb:p45 basic leucine-zipper nuclear factor(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548045|imex:IM-13585-170 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:XP_011508394.1|ensembl:ENSG00000117475(gene)|ensembl:ENST00000329281(transcript)|ensembl:ENST00000367808(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007030"(Golgi organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|interpro:IPR013183(Protein of unknown function DUF1721, fungi)|interpro:IPR027095|mint:Q9H2G9|reactome:R-HSA-162658|refseq:NP_003657.1|ensembl:ENSP00000327541|ensembl:ENST00000367807|ensembl:ENSP00000356781|ensembl:ENSP00000356782|refseq:NP_001307901.1|refseq:NP_001307902.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:FqMAghbeSRbqLmtaKELM5JZ+H3s9606 intact-crc:682D35B0006B0E12|rigid:b/htFGpYcQs/CJ0tWISc00Uad5w false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14503 uniprotkb:P03431 intact:EBI-711810|uniprotkb:Q96TD3|ensembl:ENSP00000256495 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:bhe40_human(display_long)|uniprotkb:BHLHE40(gene name)|psi-mi:BHLHE40(display_short)|uniprotkb:Differentially expressed in chondrocytes protein 1(gene name synonym)|uniprotkb:Enhancer-of-split and hairy-related protein 2(gene name synonym)|uniprotkb:Stimulated by retinoic acid gene 13 protein(gene name synonym)|uniprotkb:BHLHB2(gene name synonym)|uniprotkb:DEC1(gene name synonym)|uniprotkb:SHARP2(gene name synonym)|uniprotkb:STRA13(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 2(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548050|imex:IM-13585-92 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000134107(gene)|ensembl:ENST00000256495(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_003661.1|dip:DIP-36698N|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:O14503|reactome:R-HSA-1368108 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:JZrZ1Yo2PF33s9Lf8rLTHCqoptk9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:12B4CD730C74A4E2|rigid:YnqcJyDs2C/C913HmztDfHcUMlU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:O14503 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-711810|uniprotkb:Q96TD3|ensembl:ENSP00000256495 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:bhe40_human(display_long)|uniprotkb:BHLHE40(gene name)|psi-mi:BHLHE40(display_short)|uniprotkb:Differentially expressed in chondrocytes protein 1(gene name synonym)|uniprotkb:Enhancer-of-split and hairy-related protein 2(gene name synonym)|uniprotkb:Stimulated by retinoic acid gene 13 protein(gene name synonym)|uniprotkb:BHLHB2(gene name synonym)|uniprotkb:DEC1(gene name synonym)|uniprotkb:SHARP2(gene name synonym)|uniprotkb:STRA13(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548055|imex:IM-13585-166 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 ensembl:ENSG00000134107(gene)|ensembl:ENST00000256495(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_003661.1|dip:DIP-36698N|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:O14503|reactome:R-HSA-1368108 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:JZrZ1Yo2PF33s9Lf8rLTHCqoptk9606 intact-crc:3F7E4CD0A0249814|rigid:8SftS5miBTKA35DNgIlafKC0yOo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:O75569 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-713955|ensembl:ENSP00000318176|uniprotkb:Q53G24|uniprotkb:Q6X7T5|uniprotkb:Q8NDK4|uniprotkb:A8K3I6 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:prkra_human(display_long)|uniprotkb:Protein activator of the interferon-induced protein kinase(gene name synonym)|uniprotkb:PKR-associated protein X(gene name synonym)|uniprotkb:PKR-associating protein X(gene name synonym)|uniprotkb:HSD-14(orf name)|uniprotkb:PRKRA(gene name)|psi-mi:PRKRA(display_short)|uniprotkb:RAX(gene name synonym)|uniprotkb:PACT(gene name synonym)|uniprotkb:HSD14(orf name)|uniprotkb:Protein kinase, interferon-inducible double-stranded RNA-dependent activator(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548060|imex:IM-13585-239 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008047"(enzyme activator activity)|ensembl:ENSG00000180228(gene)|ensembl:ENST00000325748(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR033363|interpro:IPR044465|interpro:IPR044466|interpro:IPR044467|mint:O75569|rcsb pdb:2DIX|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_001132989.1|refseq:NP_001132990.1|refseq:NP_003681.1|dip:DIP-41809N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:tZfziopZlC+1d3De97G3kDY+Tog9606 intact-crc:42C936AFB1E6B170|rigid:BqmPSl1lkQ7ddZBMYy/iu/zcDp8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O75569 uniprotkb:P03485 intact:EBI-713955|ensembl:ENSP00000318176|uniprotkb:Q53G24|uniprotkb:Q6X7T5|uniprotkb:Q8NDK4|uniprotkb:A8K3I6 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:prkra_human(display_long)|uniprotkb:Protein activator of the interferon-induced protein kinase(gene name synonym)|uniprotkb:PKR-associated protein X(gene name synonym)|uniprotkb:PKR-associating protein X(gene name synonym)|uniprotkb:HSD-14(orf name)|uniprotkb:PRKRA(gene name)|psi-mi:PRKRA(display_short)|uniprotkb:RAX(gene name synonym)|uniprotkb:PACT(gene name synonym)|uniprotkb:HSD14(orf name)|uniprotkb:Protein kinase, interferon-inducible double-stranded RNA-dependent activator(gene name synonym) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548065|imex:IM-13585-202 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008047"(enzyme activator activity)|ensembl:ENSG00000180228(gene)|ensembl:ENST00000325748(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR033363|interpro:IPR044465|interpro:IPR044466|interpro:IPR044467|mint:O75569|rcsb pdb:2DIX|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_001132989.1|refseq:NP_001132990.1|refseq:NP_003681.1|dip:DIP-41809N go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:tZfziopZlC+1d3De97G3kDY+Tog9606 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:BDAE7AC7927ACF85|rigid:SfurrgDyOl1Y0pHvfWhxc/4G1EY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q8ND90 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-302345|uniprotkb:O95144|uniprotkb:Q8NG07|ensembl:ENSP00000318914|uniprotkb:A8K4L5 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:pnma1_human(display_long)|uniprotkb:PNMA1(gene name)|psi-mi:PNMA1(display_short)|uniprotkb:MA1(gene name synonym)|uniprotkb:Neuron- and testis-specific protein 1(gene name synonym)|uniprotkb:37 kDa neuronal protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548072|imex:IM-13585-246 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:NP_006020.4|ensembl:ENSG00000176903(gene)|ensembl:ENST00000316836(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR026523|interpro:IPR026528|mint:Q8ND90 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:/lx3CB7d/dv4xIgWQrCETPA0Qcw9606 intact-crc:275EC5D23ABD0C55|rigid:wp2Q1qopliqEU9RxSpVIRMQbd2Y false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03466 uniprotkb:Q9Y5V3 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 intact:EBI-716006|uniprotkb:Q5VSH6|uniprotkb:Q8IZ84|uniprotkb:Q8WY92|uniprotkb:Q9H352|uniprotkb:Q9HBT4|uniprotkb:Q9UF36|ensembl:ENSP00000325333|ensembl:ENSP00000364874|ensembl:ENSP00000364927 psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:magd1_human(display_long)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:MAGE tumor antigen CCF(gene name synonym)|uniprotkb:MAGED1(gene name)|psi-mi:MAGED1(display_short)|uniprotkb:NRAGE(gene name synonym)|uniprotkb:PRO2292(orf name)|uniprotkb:PP2250(orf name) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548077|imex:IM-13585-84 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 refseq:NP_001005332.1|refseq:NP_001005333.1|refseq:NP_008917.3|ensembl:ENSP00000325333|ensembl:ENST00000375695|ensembl:ENSP00000364847|ensembl:ENSP00000364874|ensembl:ENSP00000364927|refseq:XP_011529137.1|refseq:XP_016885467.1|refseq:XP_016885468.1|refseq:XP_016885469.1|ensembl:ENSG00000179222(gene)|ensembl:ENST00000326587(transcript)|ensembl:ENST00000375722(transcript)|ensembl:ENST00000375772(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9Y5V3|reactome:R-HSA-193648|reactome:R-HSA-418889 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 rogid:UTg0r4zGMXfTZqBN4SFmgu6IukI9606 intact-crc:744464D9621D116A|rigid:Tq5w21hLZ9BB3EdKw+6P8oZtWCY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03466 uniprotkb:P51116 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113 psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548082|imex:IM-13585-222 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606 intact-crc:6F73F7529043B04A|rigid:xGJEQjNPJnbRWgNcB78EKZDBp9w false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P51116 uniprotkb:P03496 intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548088|imex:IM-13585-86 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:AD7C496EDCEF494C|rigid:eazZZuDczy6YwCDwijP3mX+45fY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P51116 uniprotkb:P03431 intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548095|imex:IM-13585-149 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:504118FFA7AC4EF2|rigid:2vnkYv603mB50pKNWdzqVBX7lz8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P51116 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548100|imex:IM-13585-171 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606 intact-crc:504118FFA7AC4EF2|rigid:2vnkYv603mB50pKNWdzqVBX7lz8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y5P4 uniprotkb:P03452 intact:EBI-739994|uniprotkb:Q96Q85|uniprotkb:Q96Q88|uniprotkb:Q9H2S7|uniprotkb:Q9H2S8|uniprotkb:Q53YV1|uniprotkb:Q53YV2|uniprotkb:A8K7S2|uniprotkb:B3KUB7|ensembl:ENSP00000261415|ensembl:ENSP00000494110|ensembl:ENSP00000495760 intact:EBI-2548105|uniprotkb:A4GXH4|uniprotkb:Q20N38|uniprotkb:Q83964|uniprotkb:Q8JUU5 psi-mi:cert_human(display_long)|uniprotkb:CERT1(gene name)|psi-mi:CERT1(display_short)|uniprotkb:CERT(gene name synonym)|uniprotkb:COL4A3BP(gene name synonym)|uniprotkb:Collagen type IV alpha-3-binding protein(gene name synonym)|uniprotkb:Goodpasture antigen-binding protein(gene name synonym)|uniprotkb:STARD11(gene name synonym)|uniprotkb:START domain-containing protein 11(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 11(gene name synonym) psi-mi:hema_i34a1(display_long)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548131|imex:IM-13585-169 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123577.1|refseq:NP_005704.1|refseq:NP_112729.1|refseq:XP_016864408.1|rcsb pdb:2E3P|rcsb pdb:2E3Q|rcsb pdb:2E3R|rcsb pdb:2E3S|rcsb pdb:2RSG|rcsb pdb:2Z9Y|rcsb pdb:2Z9Z|rcsb pdb:3H3Q|rcsb pdb:3H3R|rcsb pdb:3H3S|rcsb pdb:3H3T|rcsb pdb:4HHV|rcsb pdb:5JJD|rcsb pdb:5ZYG|rcsb pdb:5ZYH|rcsb pdb:5ZYI|rcsb pdb:5ZYJ|rcsb pdb:5ZYK|rcsb pdb:5ZYL|rcsb pdb:5ZYM|rcsb pdb:6IEZ|rcsb pdb:6IF0|rcsb pdb:6J0O|rcsb pdb:6J81|reactome:R-HSA-1660661|ensembl:ENSG00000113163(gene)|ensembl:ENST00000261415(transcript)|ensembl:ENST00000643780(transcript)|ensembl:ENST00000644072(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006955"(immune response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035621"(ER to Golgi ceramide transport)|go:"GO:0035627"(ceramide transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0097001"(ceramide binding)|go:"GO:0120009"(intermembrane lipid transfer)|go:"GO:0120012"(intermembrane sphingolipid transfer)|go:"GO:0120017"(ceramide transfer activity)|go:"GO:1902387"(ceramide 1-phosphate binding)|go:"GO:1902388"(ceramide 1-phosphate transfer activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002913(Lipid-binding START)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023393|interpro:IPR041952|mint:Q9Y5P4|rcsb pdb:2E3M|rcsb pdb:2E3N|rcsb pdb:2E3O|refseq:XP_006714576.1 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:1RU7|rcsb pdb:1RVX|rcsb pdb:1RVZ|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-198933|go:"GO:0046761"(viral budding from plasma membrane)|refseq:NP_040980.1|interpro:IPR008980(Viral capsid/haemagglutinin protein)|interpro:IPR013828(Haemagglutinin, HA1 chain, alpha/beta region)|interpro:IPR000149(Haemagglutinin, influenza A/B virus type, HA1 chain)|interpro:IPR001364(Haemagglutinin, influenza A/B virus type, HA1/HA2 chain)|mint:P03452 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:AohUpOJQHInz8f5bKv9/Xb5K+/Y9606 rogid:gouXSFq22QLERoidFm6ju2SwoIE211044 intact-crc:E9222019F3D8FB3E|rigid:1UH097E7ERfW4QPUKA7DjDSBwxg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:Q6IB77 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-715463|uniprotkb:O14833|uniprotkb:Q96QK7|ensembl:ENSP00000340200|ensembl:ENSP00000431688|ensembl:ENSP00000484592|uniprotkb:H1AE11 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:glyat_human(display_long)|uniprotkb:"Acyl-CoA:glycine N-acyltransferase"(gene name synonym)|uniprotkb:Aralkyl acyl-CoA N-acyltransferase(gene name synonym)|uniprotkb:"Aralkyl acyl-CoA:amino acid N-acyltransferase"(gene name synonym)|uniprotkb:"HRP-1(CLP)"(gene name synonym)|uniprotkb:GLYAT(gene name)|psi-mi:GLYAT(display_short)|uniprotkb:ACGNAT(gene name synonym)|uniprotkb:CAT(gene name synonym)|uniprotkb:GAT(gene name synonym)|uniprotkb:"Benzoyl-coenzyme A:glycine N-acyltransferase"(gene name synonym)|uniprotkb:Glycine N-benzoyltransferase(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548136|imex:IM-13585-224 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 refseq:NP_005829.3|refseq:NP_964011.2|ensembl:ENSG00000149124(gene)|ensembl:ENST00000344743(transcript)|ensembl:ENST00000529732(transcript)|ensembl:ENST00000611865(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0032787"(monocarboxylic acid metabolic process)|go:"GO:0047961"(glycine N-acyltransferase activity)|go:"GO:0047962"(glycine N-benzoyltransferase activity)|go:"GO:1901787"(benzoyl-CoA metabolic process)|interpro:IPR010313(Glycine N-acyltransferase)|interpro:IPR013652(Glycine N-acyltransferase, C-terminal)|interpro:IPR015938(Glycine N-acyltransferase, N-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|reactome:R-HSA-177128|reactome:R-HSA-177135 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:7Q3j6NvssUY3jEGbaNgWq261mrE9606 intact-crc:ED6357F814397123|rigid:ya+7c070rSG2ajp+/V4rY42XBgg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O75608 uniprotkb:P03496 intact:EBI-1052185|uniprotkb:O43202|uniprotkb:Q9UQF9|ensembl:ENSP00000320043 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:lypa1_human(display_long)|uniprotkb:Lysophospholipase 1(gene name synonym)|uniprotkb:Lysophospholipase I(gene name synonym)|uniprotkb:LYPLA1(gene name)|psi-mi:LYPLA1(display_short)|uniprotkb:APT1(gene name synonym)|uniprotkb:LPL1(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548141|imex:IM-13585-91 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006321.1|refseq:NP_001266285.1|refseq:NP_001266286.1|refseq:NP_001266287.1|refseq:NP_001266288.1|refseq:NP_001266289.1|ensembl:ENSG00000120992(gene)|ensembl:ENST00000316963(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0016298"(lipase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003140(Phospholipase/carboxylesterase)|interpro:IPR029058|rcsb pdb:1FJ2|rcsb pdb:5SYM|rcsb pdb:6QGN|go:"GO:0005737"(cytoplasm)|rcsb pdb:6QGO|rcsb pdb:6QGQ|rcsb pdb:6QGS|reactome:R-HSA-203615|reactome:R-HSA-9648002 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:y/NsD5HcH2FjnwUrSCBzeevQU+s9606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:EF544EAF24F35D5B|rigid:AHVGR7/VDcr6U0yTwwPCLypm6E0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O43889 uniprotkb:P03468 intact:EBI-625002|uniprotkb:O14671|uniprotkb:O14919|uniprotkb:Q96GK8|uniprotkb:Q9H2W3|uniprotkb:Q9UE77|ensembl:ENSP00000342136|uniprotkb:D0PTW6|uniprotkb:Q5TCV1 intact:EBI-2547744|uniprotkb:A4GXH6|uniprotkb:Q20N35|uniprotkb:Q84043|uniprotkb:Q8JUU4 psi-mi:creb3_human(display_long)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Leucine zipper protein(gene name synonym) psi-mi:nram_i34a1(display_long)|uniprotkb:NA(gene name)|psi-mi:NA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548146|imex:IM-13585-87 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006935"(chemotaxis)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019043"(establishment of viral latency)|go:"GO:0019046"(release from viral latency)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029808|mint:O43889|reactome:R-HSA-8874211|go:"GO:0035497"(cAMP response element binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043025"(neuronal cell body)|refseq:NP_006359.3|dip:DIP-33935N go:"GO:0000139"(Golgi membrane)|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0046730"(induction by virus of host immune response)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:0055036"(virion membrane)|refseq:NP_040981.1|interpro:IPR001860(Glycoside hydrolase, family 34)|interpro:IPR033654|reactome:R-HSA-168275|reactome:R-HSA-168277|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-168255|interpro:IPR036278|rcsb pdb:6WZY|rcsb pdb:6X00 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2018/04/06 rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606 rogid:YVcAxjIk6bzrYuQKio0NfZB9PG4211044 intact-crc:2D19196F790DFF9C|rigid:JCM3CwzUx/4qtYtWOcVPyaYb5lw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O43889 uniprotkb:P03452 intact:EBI-625002|uniprotkb:O14671|uniprotkb:O14919|uniprotkb:Q96GK8|uniprotkb:Q9H2W3|uniprotkb:Q9UE77|ensembl:ENSP00000342136|uniprotkb:D0PTW6|uniprotkb:Q5TCV1 intact:EBI-2548105|uniprotkb:A4GXH4|uniprotkb:Q20N38|uniprotkb:Q83964|uniprotkb:Q8JUU5 psi-mi:creb3_human(display_long)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Leucine zipper protein(gene name synonym) psi-mi:hema_i34a1(display_long)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548151|imex:IM-13585-90 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006935"(chemotaxis)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019043"(establishment of viral latency)|go:"GO:0019046"(release from viral latency)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029808|mint:O43889|reactome:R-HSA-8874211|go:"GO:0035497"(cAMP response element binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043025"(neuronal cell body)|refseq:NP_006359.3|dip:DIP-33935N go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:1RU7|rcsb pdb:1RVX|rcsb pdb:1RVZ|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-198933|go:"GO:0046761"(viral budding from plasma membrane)|refseq:NP_040980.1|interpro:IPR008980(Viral capsid/haemagglutinin protein)|interpro:IPR013828(Haemagglutinin, HA1 chain, alpha/beta region)|interpro:IPR000149(Haemagglutinin, influenza A/B virus type, HA1 chain)|interpro:IPR001364(Haemagglutinin, influenza A/B virus type, HA1/HA2 chain)|mint:P03452 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2018/04/06 rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606 rogid:gouXSFq22QLERoidFm6ju2SwoIE211044 intact-crc:FF4BE6F955831F80|rigid:X+azHOQgGlsvjd1NA/aNZxVLvSU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:O43889 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-625002|uniprotkb:O14671|uniprotkb:O14919|uniprotkb:Q96GK8|uniprotkb:Q9H2W3|uniprotkb:Q9UE77|ensembl:ENSP00000342136|uniprotkb:D0PTW6|uniprotkb:Q5TCV1 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:creb3_human(display_long)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Leucine zipper protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548161|imex:IM-13585-190 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006935"(chemotaxis)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019043"(establishment of viral latency)|go:"GO:0019046"(release from viral latency)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029808|mint:O43889|reactome:R-HSA-8874211|go:"GO:0035497"(cAMP response element binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043025"(neuronal cell body)|refseq:NP_006359.3|dip:DIP-33935N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2018/04/06 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606 intact-crc:2C4D5E42FDF47848|rigid:tKlZMnGdkWOXtX3XQd+pXWJn8yI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O75525 uniprotkb:P03496 intact:EBI-722504|uniprotkb:Q6NUL8|uniprotkb:Q9UPA8|ensembl:ENSP00000348108 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:khdr3_human(display_long)|uniprotkb:Sam68-like mammalian protein 2(gene name synonym)|uniprotkb:Sam68-like phosphotyrosine protein(gene name synonym)|uniprotkb:RNA-binding protein T-Star(gene name synonym)|uniprotkb:KHDRBS3(gene name)|psi-mi:KHDRBS3(display_short)|uniprotkb:SALP(gene name synonym)|uniprotkb:SLM2(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548166|imex:IM-13585-88 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006549.1|ensembl:ENSG00000131773(gene)|ensembl:ENST00000355849(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:O75525|rcsb pdb:5EL3|rcsb pdb:5ELR|rcsb pdb:5ELS|rcsb pdb:5ELT|rcsb pdb:5EMO|reactome:R-HSA-8849468 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:9ZoB3JVp0Q9nxeFRsmWhNThzWoE9606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:FFCCE883C402F099|rigid:1bbhqgd7PCVuoB/PClc3lpyjhvc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q93062 uniprotkb:P03431 intact:EBI-740322|uniprotkb:Q92516|uniprotkb:Q92517|uniprotkb:Q92518|uniprotkb:Q96J26|uniprotkb:D3DSU9|ensembl:ENSP00000318102|ensembl:ENSP00000380486 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:rbpms_human(display_long)|uniprotkb:RBPMS(gene name)|psi-mi:RBPMS(display_short)|uniprotkb:HERMES(gene name synonym)|uniprotkb:Heart and RRM expressed sequence(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548171|imex:IM-13585-216 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008710.1|refseq:NP_001008711.1|refseq:NP_001008712.1|refseq:NP_006858.1|ensembl:ENSG00000157110(gene)|ensembl:ENST00000320203(transcript)|ensembl:ENST00000397323(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q93062|rcsb pdb:1BNY|rcsb pdb:5CYJ|rcsb pdb:5DET|refseq:XP_016868475.1 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:3PsLJDzqs+19eVFeQlN+yLielYM9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:C82144DD1DFB2463|rigid:LWv/g+M5XXO52bNJ8d3FU0VP0vc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q93062 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-740322|uniprotkb:Q92516|uniprotkb:Q92517|uniprotkb:Q92518|uniprotkb:Q96J26|uniprotkb:D3DSU9|ensembl:ENSP00000318102|ensembl:ENSP00000380486 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:rbpms_human(display_long)|uniprotkb:RBPMS(gene name)|psi-mi:RBPMS(display_short)|uniprotkb:HERMES(gene name synonym)|uniprotkb:Heart and RRM expressed sequence(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548176|imex:IM-13585-180 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:NP_001008710.1|refseq:NP_001008711.1|refseq:NP_001008712.1|refseq:NP_006858.1|ensembl:ENSG00000157110(gene)|ensembl:ENST00000320203(transcript)|ensembl:ENST00000397323(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q93062|rcsb pdb:1BNY|rcsb pdb:5CYJ|rcsb pdb:5DET|refseq:XP_016868475.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:3PsLJDzqs+19eVFeQlN+yLielYM9606 intact-crc:CE4BE4DEC82C30F8|rigid:I1YXuL5QEhobLkmea1XFu1M1oNk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06821 uniprotkb:Q93062 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 intact:EBI-740322|uniprotkb:Q92516|uniprotkb:Q92517|uniprotkb:Q92518|uniprotkb:Q96J26|uniprotkb:D3DSU9|ensembl:ENSP00000318102|ensembl:ENSP00000380486 psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:rbpms_human(display_long)|uniprotkb:RBPMS(gene name)|psi-mi:RBPMS(display_short)|uniprotkb:HERMES(gene name synonym)|uniprotkb:Heart and RRM expressed sequence(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548181|imex:IM-13585-93 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 refseq:NP_001008710.1|refseq:NP_001008711.1|refseq:NP_001008712.1|refseq:NP_006858.1|ensembl:ENSG00000157110(gene)|ensembl:ENST00000320203(transcript)|ensembl:ENST00000397323(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q93062|rcsb pdb:1BNY|rcsb pdb:5CYJ|rcsb pdb:5DET|refseq:XP_016868475.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 rogid:3PsLJDzqs+19eVFeQlN+yLielYM9606 intact-crc:AA7D12222C547E99|rigid:V/G3JlguW5O7j4HdeiWpxnifPHo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03485 uniprotkb:Q96B26 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 intact:EBI-371922|uniprotkb:O43480|uniprotkb:Q5TBA5|ensembl:ENSP00000374354 psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:exos8_human(display_long)|uniprotkb:OIP2(gene name synonym)|uniprotkb:RRP43(gene name synonym)|uniprotkb:EXOSC8(gene name)|psi-mi:EXOSC8(display_short)|uniprotkb:Ribosomal RNA-processing protein 43(gene name synonym)|uniprotkb:Exosome component 8(gene name synonym)|uniprotkb:p9(gene name synonym)|uniprotkb:Opa-interacting protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548186|imex:IM-13585-225 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 refseq:NP_852480.1|ensembl:ENSG00000120699(gene)|ensembl:ENST00000389704(transcript)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034473"(U1 snRNA 3'-end processing)|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0034476"(U5 snRNA 3'-end processing)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071042"(nuclear polyadenylation-dependent mRNA catabolic process)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR020568|interpro:IPR027408|interpro:IPR033196|go:"GO:0005829"(cytosol)|mint:Q96B26|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|interpro:IPR036345|dip:DIP-31133N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 rogid:y/cReHiPMubzNruyETohBjbRick9606 intact-crc:83290622A8C78714|rigid:Fu1Y54akIz3g2S02PMnTnlRH/IY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UKT9 uniprotkb:P03431 intact:EBI-747204|uniprotkb:Q8WWQ9|uniprotkb:Q8WWR0|uniprotkb:Q8WWR1|uniprotkb:Q8WWR2|uniprotkb:Q8WWR3|uniprotkb:Q8N574|uniprotkb:B4DVV5|uniprotkb:Q69BL6|uniprotkb:Q69BL7|uniprotkb:Q69BL8|uniprotkb:Q69BL9|uniprotkb:Q69BM0|uniprotkb:Q69BM1|uniprotkb:Q69BM2|uniprotkb:Q69BM3|uniprotkb:Q69BM5|ensembl:ENSP00000344544 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:ikzf3_human(display_long)|uniprotkb:ZNFN1A3(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 3(gene name synonym)|uniprotkb:IKZF3(gene name)|psi-mi:IKZF3(display_short) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548194|imex:IM-13585-214 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271443.1|refseq:NP_001271444.1|refseq:NP_036613.2|refseq:NP_899051.1|refseq:NP_899052.1|refseq:NP_899053.1|refseq:NP_899054.1|refseq:NP_899055.1|refseq:NP_001271445.1|refseq:NP_001244337.1|refseq:NP_001244338.1|refseq:NP_001244339.1|refseq:NP_001244340.1|refseq:NP_001244341.1|refseq:NP_001244342.1|refseq:NP_001244343.1|ensembl:ENSG00000161405(gene)|ensembl:ENST00000346872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0009617"(response to bacterium)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|go:"GO:0046872"(metal ion binding)|dip:DIP-56975N go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:2Kp6LefSLfK5VIiE6DmQusFIfMY9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:910865515F27EB18|rigid:zvwqmhKOLAvn8e4iopPMUi0Se1w false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:Q9UL40 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2462313|uniprotkb:B7Z367|uniprotkb:Q68CV9|uniprotkb:Q6ZMW1|ensembl:ENSP00000350869 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:zn346_human(display_long)|uniprotkb:ZNF346(gene name)|psi-mi:ZNF346(display_short)|uniprotkb:JAZ(gene name synonym)|uniprotkb:Just another zinc finger protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548199|imex:IM-13585-217 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 refseq:NP_001295142.1|refseq:NP_001295143.1|refseq:NP_001295148.1|refseq:NP_001295152.1|refseq:NP_036411.1|refseq:XP_016864784.1|refseq:XP_016864785.1|ensembl:ENSG00000113761(gene)|ensembl:ENST00000358149(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0035198"(miRNA binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|rcsb pdb:2MKD|rcsb pdb:2MKN go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:bK/y4NYSSsa1tcNjtbmsEmkSp7Q9606 intact-crc:12822C94ADF6707E|rigid:W9ydv3Uux/mzfcp3k41Rwj4zUQk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:Q9UL40 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-2462313|uniprotkb:B7Z367|uniprotkb:Q68CV9|uniprotkb:Q6ZMW1|ensembl:ENSP00000350869 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:zn346_human(display_long)|uniprotkb:ZNF346(gene name)|psi-mi:ZNF346(display_short)|uniprotkb:JAZ(gene name synonym)|uniprotkb:Just another zinc finger protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548204|imex:IM-13585-182 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 refseq:NP_001295142.1|refseq:NP_001295143.1|refseq:NP_001295148.1|refseq:NP_001295152.1|refseq:NP_036411.1|refseq:XP_016864784.1|refseq:XP_016864785.1|ensembl:ENSG00000113761(gene)|ensembl:ENST00000358149(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0035198"(miRNA binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|rcsb pdb:2MKD|rcsb pdb:2MKN go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:bK/y4NYSSsa1tcNjtbmsEmkSp7Q9606 intact-crc:EFBF7D05D6B577C0|rigid:+GeKy0V/T/DibzSW5jwpNIl+x9A false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:Q9H3Q1 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-744665|uniprotkb:O95828|uniprotkb:Q96FT3|ensembl:ENSP00000338258|uniprotkb:B3KUS7 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:borg4_human(display_long)|uniprotkb:Binder of Rho GTPases 4(gene name synonym)|uniprotkb:CDC42EP4(gene name)|psi-mi:CDC42EP4(display_short)|uniprotkb:BORG4(gene name synonym)|uniprotkb:CEP4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548209|imex:IM-13585-220 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 refseq:NP_036253.2|ensembl:ENSG00000179604(gene)|ensembl:ENST00000335793(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR029273|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|refseq:XP_005257239.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:HC1q85v0D6AOKZ82FKaBdAEv1mE9606 intact-crc:084B72242F6D7C4F|rigid:RxNHn9MyA3oC94zyb/TdbNrzGZY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:Q9Y305 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2548214|ensembl:ENSP00000336580|uniprotkb:B3KNC9|uniprotkb:B7ZM94 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:acot9_human(display_long)|uniprotkb:ACOT9(gene name)|psi-mi:ACOT9(display_short)|uniprotkb:Acyl-CoA thioester hydrolase 9(gene name synonym)|uniprotkb:CGI-16(orf name) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548244|imex:IM-13585-198 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 ensembl:ENSG00000123130(gene)|ensembl:ENST00000336430(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|interpro:IPR029069|interpro:IPR033120|mint:Q9Y305|reactome:R-HSA-77289|refseq:NP_001028755.2|refseq:NP_001032248.1|refseq:NP_001317188.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:WbPOPMGV/9XQRxLufTKCXvYQH/Y9606 intact-crc:B0D449B7F531C623|rigid:DOcOXn6j+Q4k24wpo2T2R0M9HI8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O60684 uniprotkb:P03466 intact:EBI-359923|uniprotkb:Q5VVU3|uniprotkb:B2RDC7|ensembl:ENSP00000362728|uniprotkb:D3DPP5 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:ima7_human(display_long)|uniprotkb:KPNA6(gene name)|psi-mi:KPNA6(display_short)|uniprotkb:IPOA7(gene name synonym)|uniprotkb:Karyopherin subunit alpha-6(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548249|imex:IM-13585-221 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036448.1|ensembl:ENSG00000025800(gene)|ensembl:ENST00000373625(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0019079"(viral genome replication)|go:"GO:0030682"(mitigation of host defenses by symbiont)|go:"GO:0043657"(host cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O60684|rcsb pdb:4UAD|dip:DIP-27609N go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:3NsSIcE6BHIqYlvfGRolUKD/5uc9606 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:BCC2D7C2D7EAF18C|rigid:jbLtrdfrh8mrYbxJLgzvwhQozEI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:P81877 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-748077|uniprotkb:Q8N2Q2|uniprotkb:Q9BWW6|uniprotkb:Q9Y4T7|uniprotkb:B7Z2L9|uniprotkb:E9PDA8|uniprotkb:B2R5W1|uniprotkb:B7Z1J2|uniprotkb:B7Z665|uniprotkb:D6RH18|uniprotkb:E9PB74|intact:EBI-28967061|ensembl:ENSP00000322977 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:ssbp2_human(display_long)|uniprotkb:Sequence-specific single-stranded-DNA-binding protein 2(gene name synonym)|uniprotkb:SSBP2(gene name)|psi-mi:SSBP2(display_short)|uniprotkb:SSDP2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548254|imex:IM-13585-223 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 ensembl:ENSP00000322977|ensembl:ENST00000505980|ensembl:ENSP00000423969|ensembl:ENST00000509053|ensembl:ENSP00000422961|ensembl:ENST00000514493|ensembl:ENSP00000426183|ensembl:ENST00000515395|ensembl:ENSP00000424657|refseq:NP_001243661.1|refseq:NP_036578.2|refseq:NP_001243665.1|refseq:NP_001243663.1|refseq:NP_001243664.1|refseq:NP_001243662.1|ensembl:ENSG00000145687(gene)|ensembl:ENST00000320672(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR008116(Sequence-specific single-strand DNA-binding protein)|mint:P81877|rcsb pdb:6IWV|rcsb pdb:6TYD|dip:DIP-29459N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:CMmZPTurp1G6Y2q7GP/pTMlFM549606 intact-crc:D64F3F0B71242484|rigid:jrdOM0degfG77yQpMxnkImJ69IY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06821 uniprotkb:Q9Y6X0 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 intact:EBI-2548259|intact:EBI-28969274|ensembl:ENSP00000497406|ensembl:ENSP00000502995|ensembl:ENSP00000503094|ensembl:ENSP00000503656|ensembl:ENSP00000504398|uniprotkb:A6H8W5|uniprotkb:Q9UEF3|uniprotkb:Q6P6C3 psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:setbp_human(display_long)|uniprotkb:SETBP1(gene name)|psi-mi:SETBP1(display_short)|uniprotkb:KIAA0437(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548273|imex:IM-13585-227 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 ensembl:ENSG00000152217(gene)|ensembl:ENST00000649279(transcript)|ensembl:ENST00000677068(transcript)|ensembl:ENST00000677077(transcript)|ensembl:ENST00000677130(transcript)|ensembl:ENST00000678152(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|interpro:IPR017956|ensembl:ENST00000426838|ensembl:ENSP00000390687|ensembl:ENSP00000497406|ensembl:ENSP00000504398|ensembl:ENSP00000503656|ensembl:ENSP00000503094|ensembl:ENSP00000502995|refseq:NP_001123582.1|refseq:NP_056374.2 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 rogid:bPLw8rppZYzLANH100jgHI5yfhI9606 intact-crc:C7DE95FA342AA31C|rigid:WGJP2oy5i0s8VBUAT9PojSNoqPo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03485 uniprotkb:Q9H190 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013 psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548280|imex:IM-13585-175 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606 intact-crc:FC77587D30433B6A|rigid:RUBxBky3NXrwuKD9FyLdtiKBRE4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UJ41 uniprotkb:P03428 intact:EBI-913954|uniprotkb:B4DZM7|uniprotkb:Q3HKR2|uniprotkb:Q3HKR3|uniprotkb:Q53FG0|ensembl:ENSP00000284957|ensembl:ENSP00000415815 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:rabx5_human(display_long)|uniprotkb:Rabex-5(gene name synonym)|uniprotkb:Rabaptin-5-associated exchange factor for Rab5(gene name synonym)|uniprotkb:RAP1(gene name synonym)|uniprotkb:RABGEF1(gene name)|psi-mi:RABGEF1(display_short)|uniprotkb:RABEX5(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548290|imex:IM-13585-230 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154710(gene)|ensembl:ENST00000284957(transcript)|ensembl:ENST00000450873(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0055037"(recycling endosome)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR037191|interpro:IPR041545|rcsb pdb:1TXU|rcsb pdb:2C7M|rcsb pdb:2C7N|rcsb pdb:2OT3|rcsb pdb:4N3X|rcsb pdb:4N3Y|rcsb pdb:4N3Z|rcsb pdb:4Q9U|reactome:R-HSA-8854214|reactome:R-HSA-8876198|refseq:NP_055319.1|refseq:NP_001273989.1|refseq:NP_001273990.1|refseq:NP_001273991.1|dip:DIP-29348N go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2019/05/28 rogid:+MNigZ2IH2ogPAFA5YTYT0rGWYg9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:64D8B992FD0614A1|rigid:w0n1Q4mxpM9AiV70TSZjOX/uPPI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:Q6IBW4 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2548296|ensembl:ENSP00000410088|uniprotkb:Q9BUT3|uniprotkb:Q9BVD1|uniprotkb:B7WPH1|uniprotkb:O43788|uniprotkb:Q13391|uniprotkb:Q96C14|uniprotkb:Q96GJ0|uniprotkb:Q9BQ71 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:cndh2_human(display_long)|uniprotkb:NCAPH2(gene name)|psi-mi:NCAPH2(display_short)|uniprotkb:CAPH2(gene name synonym)|uniprotkb:Non-SMC condensin II complex subunit H2(gene name synonym)|uniprotkb:Chromosome-associated protein H2(gene name synonym)|uniprotkb:Kleisin-beta(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548338|imex:IM-13585-173 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 ensembl:ENSG00000025770(gene)|ensembl:ENST00000420993(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051309"(female meiosis chromosome separation)|interpro:IPR009378(Protein of unknown function DUF1032)|interpro:IPR031719|interpro:IPR031737|interpro:IPR031739|mint:Q6IBW4|reactome:R-HSA-2299718|refseq:NP_001171940.1|refseq:NP_055366.3|refseq:NP_689512.2|dip:DIP-43901N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:GTOZg0OoAHm+tj3C8/3sCGM+G5E9606 intact-crc:0715788319031363|rigid:T/qKFzM/Nh21w3CaATplYmWjKto false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9NZF1 uniprotkb:P03431 intact:EBI-2115535|uniprotkb:C1K3N2|ensembl:ENSP00000309509|ensembl:ENSP00000399700|ensembl:ENSP00000412230|ensembl:ENSP00000422526 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:plac8_human(display_long)|uniprotkb:PLAC8(gene name)|psi-mi:PLAC8(display_short)|uniprotkb:Protein C15(gene name synonym)|uniprotkb:BM-004(orf name) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548344|imex:IM-13585-179 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001124187.1|refseq:NP_001124188.1|refseq:NP_057703.1|ensembl:ENSG00000145287(gene)|ensembl:ENST00000311507(transcript)|ensembl:ENST00000411416(transcript)|ensembl:ENST00000426923(transcript)|ensembl:ENST00000505406(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009409"(response to cold)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006461(Protein of unknown function Cys-rich)|reactome:R-HSA-6798695 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:kiGb5oVM4urWHwPjyTcZp65aqD09606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:F3EE1273A070FE88|rigid:NhEwx2s8sfvXMonU/UVTVlhsNAA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UJC3 uniprotkb:P03428 intact:EBI-746704|uniprotkb:O60561|uniprotkb:Q5TG44|uniprotkb:A8MU44|uniprotkb:B4DX15|uniprotkb:A8K8E9|intact:EBI-10969618|ensembl:ENSP00000360252 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:hook1_human(display_long)|uniprotkb:HOOK1(gene name)|psi-mi:HOOK1(display_short) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548349|imex:IM-13585-177 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056972.1|ensembl:ENSG00000134709(gene)|ensembl:ENST00000371208(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007030"(Golgi organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905198"(manchette assembly)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|mint:Q9UJC3 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:QOcYbuKfnNIlNKzos5v+0+A2h3I9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:DF45344EFA00B97A|rigid:/Z7M7+0/FWqdca8MFIufcrjN8S0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:Q9H892 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2548354|ensembl:ENSP00000433757|uniprotkb:Q8N5H9|uniprotkb:Q9NWY3 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:ttc12_human(display_long)|uniprotkb:TTC12(gene name)|psi-mi:TTC12(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548379|imex:IM-13585-191 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 ensembl:ENSG00000149292(gene)|ensembl:ENST00000529221(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0070286"(axonemal dynein complex assembly)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR043195|refseq:NP_060338.3|refseq:NP_001305462.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:2nZDzpe8LGZOZaE2ATIVM7LX6HI9606 intact-crc:95DA153ABAD20BC0|rigid:jkRHix2VezDxirYSRN53j89Reno false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:Q8N9N5 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-744695|uniprotkb:B4DNJ9|uniprotkb:Q96GJ7|uniprotkb:Q9NWY1|uniprotkb:A8MX25|uniprotkb:A8MU25|ensembl:ENSP00000286122|ensembl:ENSP00000376902|uniprotkb:B2RCF7|uniprotkb:F5GZM0 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:banp_human(display_long)|uniprotkb:Btg3-associated nuclear protein(gene name synonym)|uniprotkb:Scaffold/matrix-associated region-1-binding protein(gene name synonym)|uniprotkb:BANP(gene name)|psi-mi:BANP(display_short)|uniprotkb:SMAR1(gene name synonym)|uniprotkb:BEND1(gene name synonym)|uniprotkb:BEN domain-containing protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548385|imex:IM-13585-181 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 refseq:NP_001167010.1|refseq:NP_001167011.1|refseq:NP_001167014.1|refseq:NP_060339.2|refseq:NP_524576.2|ensembl:ENSG00000172530(gene)|ensembl:ENST00000286122(transcript)|ensembl:ENST00000393207(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR018379|interpro:IPR042343|mint:Q8N9N5|reactome:R-HSA-6804759|refseq:NP_001167012.1|refseq:NP_001167013.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:qTMuHfQDIsXAwdjSHa9hnPnKeYE9606 intact-crc:B3C2750DFBBA3321|rigid:hbETrhoSaoSXNxhbaYRATtyHCmQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N9N5 uniprotkb:P03428 intact:EBI-744695|uniprotkb:B4DNJ9|uniprotkb:Q96GJ7|uniprotkb:Q9NWY1|uniprotkb:A8MX25|uniprotkb:A8MU25|ensembl:ENSP00000286122|ensembl:ENSP00000376902|uniprotkb:B2RCF7|uniprotkb:F5GZM0 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:banp_human(display_long)|uniprotkb:Btg3-associated nuclear protein(gene name synonym)|uniprotkb:Scaffold/matrix-associated region-1-binding protein(gene name synonym)|uniprotkb:BANP(gene name)|psi-mi:BANP(display_short)|uniprotkb:SMAR1(gene name synonym)|uniprotkb:BEND1(gene name synonym)|uniprotkb:BEN domain-containing protein 1(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548390|imex:IM-13585-183 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001167010.1|refseq:NP_001167011.1|refseq:NP_001167014.1|refseq:NP_060339.2|refseq:NP_524576.2|ensembl:ENSG00000172530(gene)|ensembl:ENST00000286122(transcript)|ensembl:ENST00000393207(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR018379|interpro:IPR042343|mint:Q8N9N5|reactome:R-HSA-6804759|refseq:NP_001167012.1|refseq:NP_001167013.1 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:qTMuHfQDIsXAwdjSHa9hnPnKeYE9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:4895849F552E2004|rigid:RwGgjmxD0ciHjRlP2M1E77LJNjE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:Q8N9N5 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-744695|uniprotkb:B4DNJ9|uniprotkb:Q96GJ7|uniprotkb:Q9NWY1|uniprotkb:A8MX25|uniprotkb:A8MU25|ensembl:ENSP00000286122|ensembl:ENSP00000376902|uniprotkb:B2RCF7|uniprotkb:F5GZM0 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:banp_human(display_long)|uniprotkb:Btg3-associated nuclear protein(gene name synonym)|uniprotkb:Scaffold/matrix-associated region-1-binding protein(gene name synonym)|uniprotkb:BANP(gene name)|psi-mi:BANP(display_short)|uniprotkb:SMAR1(gene name synonym)|uniprotkb:BEND1(gene name synonym)|uniprotkb:BEN domain-containing protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548395|imex:IM-13585-185 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 refseq:NP_001167010.1|refseq:NP_001167011.1|refseq:NP_001167014.1|refseq:NP_060339.2|refseq:NP_524576.2|ensembl:ENSG00000172530(gene)|ensembl:ENST00000286122(transcript)|ensembl:ENST00000393207(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR018379|interpro:IPR042343|mint:Q8N9N5|reactome:R-HSA-6804759|refseq:NP_001167012.1|refseq:NP_001167013.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:qTMuHfQDIsXAwdjSHa9hnPnKeYE9606 intact-crc:4EFF249C80F9349F|rigid:gqMELj/dMj2liuOeM5o72k8mkxk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:Q9UHQ4 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2548400|ensembl:ENSP00000005259|ensembl:ENSP00000368412|ensembl:ENSP00000490977|ensembl:ENSP00000491801|uniprotkb:O95003|uniprotkb:G5E9L4 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:bap29_human(display_long)|uniprotkb:BCAP29(gene name)|psi-mi:BCAP29(display_short)|uniprotkb:BAP29(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548415|imex:IM-13585-187 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 refseq:XP_011514708.1|ensembl:ENSG00000075790(gene)|ensembl:ENSG00000283852(gene)|ensembl:ENST00000005259(transcript)|ensembl:ENST00000379117(transcript)|ensembl:ENST00000640518(transcript)|ensembl:ENST00000640915(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|interpro:IPR008417(B-cell receptor-associated 31-like)|interpro:IPR040463|interpro:IPR041672|mint:Q9UHQ4|rcsb pdb:4W7Y|rcsb pdb:4W7Z|rcsb pdb:4W80|refseq:NP_061332.2|refseq:XP_006716114.1|refseq:NP_001008405.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:s9pfUcldGnUfE6PBHYuZB9dqjGE9606 intact-crc:CF1CE0EB44766D53|rigid:1G02tpBRXTCeHArFFYvIAxOQfso false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7LBR1 uniprotkb:P03433 intact:EBI-2118090|uniprotkb:Q96E89|uniprotkb:Q9HD41|ensembl:ENSP00000432279 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:chm1b_human(display_long)|uniprotkb:CHMP1B(gene name)|psi-mi:CHMP1B(display_short)|uniprotkb:C18orf2(gene name synonym)|uniprotkb:Chromatin-modifying protein 1b(gene name synonym)|uniprotkb:CHMP1.5(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 46-2(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548420|imex:IM-13585-184 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065145.2|ensembl:ENSP00000432279|dip:DIP-48534N|ensembl:ENSG00000255112(gene)|ensembl:ENST00000526991(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0051301"(cell division)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:Q7LBR1|rcsb pdb:3EAB|rcsb pdb:3JC1|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:6E8G|rcsb pdb:6TZ4|rcsb pdb:6TZ5|rcsb pdb:6TZ9 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:JBzgWtpzZ/td6JuSSCIx5xpZE7M9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:15AE57F138D5FAE5|rigid:x5NaK05X/CGnLS9NbS2hgqkGotw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96AT1 uniprotkb:P03496 intact:EBI-2548425|ensembl:ENSP00000296121|ensembl:ENSP00000486878|uniprotkb:A8K0I4|uniprotkb:Q96HJ8|uniprotkb:Q9ULS7 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:k1143_human(display_long)|uniprotkb:KIAA1143(gene name)|psi-mi:KIAA1143(display_short) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548435|imex:IM-13585-188 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163807(gene)|ensembl:ENSG00000281665(gene)|ensembl:ENST00000296121(transcript)|ensembl:ENST00000627745(transcript)|interpro:IPR027911|interpro:IPR040219|refseq:NP_065747.1 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:E1Pc0mcNc/K+JNIAjz/VlB+GcrY9606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:DD37E8DF5A2527B3|rigid:s9n3nvDInysRLGdolvUZGXqSLjg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q9P1Z2 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-749920|uniprotkb:B3KVA8|uniprotkb:Q6FI59|uniprotkb:Q71RC3|uniprotkb:Q86WF8|uniprotkb:Q96JU3|uniprotkb:Q9H090|intact:EBI-2558801|ensembl:ENSP00000449960 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:caco1_human(display_long)|uniprotkb:CALCOCO1(gene name)|psi-mi:CALCOCO1(display_short)|uniprotkb:KIAA1536(gene name synonym)|uniprotkb:Calphoglin(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-3(gene name synonym)|uniprotkb:Coiled-coil coactivator protein(gene name synonym)|uniprotkb:PP13275(orf name)|uniprotkb:UNQ2436/PRO4996(orf name) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548475|imex:IM-13585-194 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:NP_001137154.1|refseq:NP_065949.1|refseq:XP_016875196.1|dip:DIP-47322N|ensembl:ENSG00000012822(gene)|ensembl:ENST00000550804(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0070016"(armadillo repeat domain binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q9P1Z2 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:4M9Qyq+7GZ1w2UAN6k0ntGQNTvw9606 intact-crc:E06D8FDA815A177F|rigid:JGtgtp49yAxPCGRMlRyoAWBPHaM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9HA38 uniprotkb:P03496 intact:EBI-2548480|ensembl:ENSP00000311221|uniprotkb:Q96A21|uniprotkb:B3KVA6|uniprotkb:D3DNR1 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:zmat3_human(display_long)|uniprotkb:ZMAT3(gene name)|psi-mi:ZMAT3(display_short)|uniprotkb:PAG608(gene name synonym)|uniprotkb:WIG1(gene name synonym)|uniprotkb:Zinc finger protein WIG-1(gene name synonym)|uniprotkb:p53-activated gene 608 protein(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548503|imex:IM-13585-174 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011511375.1|ensembl:ENSG00000172667(gene)|ensembl:ENST00000311417(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0040008"(regulation of growth)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR036236|mint:Q9HA38|refseq:NP_071915.1|refseq:NP_689426.1|refseq:XP_005247763.1 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:mnbpErYi8VtTJUbKZPLM9eLmOHY9606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:DEAACC5C7BE63133|rigid:MpVDpyYjeWMazAEASnWnUi4KIIY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96IK5 uniprotkb:P03466 intact:EBI-2548508|ensembl:ENSP00000282570|uniprotkb:Q9H826|uniprotkb:Q9H8V7|uniprotkb:Q9H927 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:gmcl1_human(display_long)|uniprotkb:GMCL1(gene name)|psi-mi:GMCL1(display_short)|uniprotkb:GCL(gene name synonym)|uniprotkb:BTBD13(gene name synonym)|uniprotkb:SPATA29(gene name synonym)|uniprotkb:Spermatogenesis-associated protein 29(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548527|imex:IM-13585-193 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000087338(gene)|ensembl:ENST00000282570(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016363"(nuclear matrix)|go:"GO:0042802"(identical protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR043380|refseq:NP_848526.1 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:ED8yqySVu7BWxpw3DUSNBZSQWrk9606 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:1EAF347489A9CC88|rigid:a/o/Li9jn3D1jHqW27pec4kDLeU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96T21 uniprotkb:P03433 intact:EBI-954116|intact:EBI-28979217|ensembl:ENSP00000364965|uniprotkb:Q9H0A1|uniprotkb:Q8IYC0|uniprotkb:Q5HYY1|uniprotkb:F8W892|uniprotkb:Q7L1Z0 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:sebp2_human(display_long)|uniprotkb:SECISBP2(gene name)|psi-mi:SECISBP2(display_short)|uniprotkb:SBP2(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548532|imex:IM-13585-200 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269617.1|refseq:NP_001269618.1|ensembl:ENSG00000187742(gene)|ensembl:ENST00000375807(transcript)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0021756"(striatum development)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0048666"(neuron development)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR029064|interpro:IPR040051|mint:Q96T21|reactome:R-HSA-2408557|ensembl:ENST00000339901|ensembl:ENSP00000364959|ensembl:ENSP00000364965|ensembl:ENST00000534113|ensembl:ENSP00000436650|refseq:NP_076982.3|refseq:XP_011517302.1|refseq:XP_006717345.1 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:KwZEgErldBNsolKlb/EK6OLJCJA9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:F0596EE5EF519340|rigid:Qn4iZfmV+B+RLtFv5S0oMkyEFD8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96FZ7 uniprotkb:P03433 intact:EBI-1049648|uniprotkb:Q53FU4|uniprotkb:Q9HAE8|uniprotkb:A8K7U0|ensembl:ENSP00000317468 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:chmp6_human(display_long)|uniprotkb:Chromatin-modifying protein 6(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 20(gene name synonym)|uniprotkb:CHMP6(gene name)|psi-mi:CHMP6(display_short)|uniprotkb:VPS20(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548537|imex:IM-13585-199 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078867.2|ensembl:ENSG00000176108(gene)|ensembl:ENST00000325167(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904902"(ESCRT III complex assembly)|interpro:IPR005024(Snf7)|mint:Q96FZ7|rcsb pdb:2K3W|rcsb pdb:3HTU|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676|go:"GO:0016020"(membrane) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:UR/trNCJYky7bD9sxvSnCz0FGkg9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:5234D21F0CAF4575|rigid:hCqW3h5XO2500JDQcQhk67w0C7E false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H898 uniprotkb:P03485 intact:EBI-2548542|ensembl:ENSP00000297737|uniprotkb:Q8WUT8 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:zmat4_human(display_long)|uniprotkb:ZMAT4(gene name)|psi-mi:ZMAT4(display_short) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548566|imex:IM-13585-201 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000297737(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR003604(Zinc finger, U1-type)|ensembl:ENSG00000165061(gene)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR036236|refseq:NP_001129203.1|refseq:NP_078921.1 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:7zQ5iec+6Ax3lNsVDSq6pSu71W09606 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:F90BFEEB53245E07|rigid:Bl4enRlfXzlinKj0VKUtDHg7hnE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H898 uniprotkb:P03431 intact:EBI-2548542|ensembl:ENSP00000297737|uniprotkb:Q8WUT8 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:zmat4_human(display_long)|uniprotkb:ZMAT4(gene name)|psi-mi:ZMAT4(display_short) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548571|imex:IM-13585-203 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000297737(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR003604(Zinc finger, U1-type)|ensembl:ENSG00000165061(gene)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR036236|refseq:NP_001129203.1|refseq:NP_078921.1 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:7zQ5iec+6Ax3lNsVDSq6pSu71W09606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:4777D8F1351E49C3|rigid:khWrHSKt1qW9UjdMFYHiNsJuHT8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H898 uniprotkb:P03496 intact:EBI-2548542|ensembl:ENSP00000297737|uniprotkb:Q8WUT8 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:zmat4_human(display_long)|uniprotkb:ZMAT4(gene name)|psi-mi:ZMAT4(display_short) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548576|imex:IM-13585-205 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000297737(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR003604(Zinc finger, U1-type)|ensembl:ENSG00000165061(gene)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR036236|refseq:NP_001129203.1|refseq:NP_078921.1 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:7zQ5iec+6Ax3lNsVDSq6pSu71W09606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:BA4A89604E5D4E7D|rigid:6zh5pXpz6DDohO6jeil50hPXRZU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q8N5R6 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-740841|intact:EBI-953781|uniprotkb:B3KQ49|uniprotkb:A8K3U4|uniprotkb:A8MPQ6|uniprotkb:A8MV61|uniprotkb:A8MVU9|uniprotkb:Q9H5Q6|uniprotkb:Q8TAX6|intact:EBI-2320546|intact:EBI-11522976 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:ccd33_human(display_long)|uniprotkb:CCDC33(gene name)|psi-mi:CCDC33(display_short)|uniprotkb:Cancer/testis antigen 61(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548585|imex:IM-13585-206 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:NP_079331.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0005777"(peroxisome)|refseq:NP_001274110.1|refseq:NP_877592.2|mint:Q8N5R6|interpro:IPR035892|interpro:IPR039889 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:eEIn7pQyfdHWx8TeLJpYy0i/gww9606 intact-crc:FB49F035FFEDA2A0|rigid:jbzpRycBqZdmWNGTIcmiMLjM/YU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8NHQ1 uniprotkb:P03466 intact:EBI-739624|ensembl:ENSP00000264982|ensembl:ENSP00000419231|uniprotkb:Q96B31|uniprotkb:Q9H2C3|uniprotkb:Q9H2Z1|uniprotkb:Q9H940|uniprotkb:D3DNE9|uniprotkb:B7Z5I8|uniprotkb:B7Z7E8|uniprotkb:F5GZX8 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:cep70_human(display_long)|uniprotkb:CEP70(gene name)|psi-mi:CEP70(display_short)|uniprotkb:BITE(gene name synonym)|uniprotkb:p10-binding protein(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548590|imex:IM-13585-204 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000114107(gene)|ensembl:ENST00000264982(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|interpro:IPR019734|interpro:IPR037692|mint:Q8NHQ1|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|ensembl:ENST00000484888(transcript)|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_077817.2|refseq:XP_016862764.1|refseq:NP_001275893.1|refseq:NP_001275894.1|refseq:NP_001275895.1|refseq:NP_001275896.1|refseq:NP_001307527.1|refseq:NP_001307529.1 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:S4yveQWcvdVtAUX65gqrJ5Dv0Mc9606 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:16B84157D6026B16|rigid:qU7P1v16ijRO/4yF5Ms51KOAxLg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q8NHQ1 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-739624|ensembl:ENSP00000264982|ensembl:ENSP00000419231|uniprotkb:Q96B31|uniprotkb:Q9H2C3|uniprotkb:Q9H2Z1|uniprotkb:Q9H940|uniprotkb:D3DNE9|uniprotkb:B7Z5I8|uniprotkb:B7Z7E8|uniprotkb:F5GZX8 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:cep70_human(display_long)|uniprotkb:CEP70(gene name)|psi-mi:CEP70(display_short)|uniprotkb:BITE(gene name synonym)|uniprotkb:p10-binding protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548595|imex:IM-13585-218 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 ensembl:ENSG00000114107(gene)|ensembl:ENST00000264982(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|interpro:IPR019734|interpro:IPR037692|mint:Q8NHQ1|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|ensembl:ENST00000484888(transcript)|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_077817.2|refseq:XP_016862764.1|refseq:NP_001275893.1|refseq:NP_001275894.1|refseq:NP_001275895.1|refseq:NP_001275896.1|refseq:NP_001307527.1|refseq:NP_001307529.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:S4yveQWcvdVtAUX65gqrJ5Dv0Mc9606 intact-crc:2FE00EF9343A8135|rigid:MX5DfMFGizOnfkeC86HDk+7G4IA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:Q8NHQ1 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-739624|ensembl:ENSP00000264982|ensembl:ENSP00000419231|uniprotkb:Q96B31|uniprotkb:Q9H2C3|uniprotkb:Q9H2Z1|uniprotkb:Q9H940|uniprotkb:D3DNE9|uniprotkb:B7Z5I8|uniprotkb:B7Z7E8|uniprotkb:F5GZX8 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:cep70_human(display_long)|uniprotkb:CEP70(gene name)|psi-mi:CEP70(display_short)|uniprotkb:BITE(gene name synonym)|uniprotkb:p10-binding protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548600|imex:IM-13585-229 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 ensembl:ENSG00000114107(gene)|ensembl:ENST00000264982(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|interpro:IPR019734|interpro:IPR037692|mint:Q8NHQ1|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|ensembl:ENST00000484888(transcript)|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_077817.2|refseq:XP_016862764.1|refseq:NP_001275893.1|refseq:NP_001275894.1|refseq:NP_001275895.1|refseq:NP_001275896.1|refseq:NP_001307527.1|refseq:NP_001307529.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:S4yveQWcvdVtAUX65gqrJ5Dv0Mc9606 intact-crc:298AAEFAE1ED95AE|rigid:X/mXAsr5A4aH1i7pbrTJpY4n4b8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q8NF50 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-2548605|uniprotkb:B7ZLP0|uniprotkb:E9PH09|ensembl:ENSP00000394888|uniprotkb:A2A350|uniprotkb:A2BDF2|uniprotkb:A4FU78|uniprotkb:Q3MV16|uniprotkb:Q5JPJ1|uniprotkb:Q8TEP1|uniprotkb:Q8WUY2|uniprotkb:Q9BYJ5|uniprotkb:Q9H1Q2|uniprotkb:Q9H1Q3|uniprotkb:Q9H308|uniprotkb:Q9H7P2|intact:EBI-11070681 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:dock8_human(display_long)|uniprotkb:DOCK8(gene name)|psi-mi:DOCK8(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548643|imex:IM-13585-231 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:XP_011516347.1|refseq:XP_011516349.1|ensembl:ENSG00000107099(gene)|ensembl:ENST00000432829(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061485"(memory T cell proliferation)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-983231|refseq:XP_011516350.1|refseq:NP_001177387.1|refseq:NP_001180465.1|refseq:NP_982272.2|refseq:XP_016870662.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:4ENO+3IOKfCUicfg8fxFQbwf4fg9606 intact-crc:A842A6872175F8EA|rigid:ibjkzcZps2tdzVIbaRzpPm9dmrA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9BXR0 uniprotkb:P03433 intact:EBI-716832|uniprotkb:Q96BQ4|uniprotkb:Q9BXQ9|uniprotkb:B4DFM7|ensembl:ENSP00000250237 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:tgt_human(display_long)|uniprotkb:tRNA-guanine transglycosylase(gene name synonym)|uniprotkb:Guanine insertion enzyme(gene name synonym)|uniprotkb:QTRT1(gene name)|psi-mi:QTRT1(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:TGUT(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548648|imex:IM-13585-234 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112486.1|ensembl:ENSG00000213339(gene)|ensembl:ENST00000250237(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006400"(tRNA modification)|go:"GO:0008479"(queuine tRNA-ribosyltransferase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0101030"(tRNA-guanine transglycosylation)|interpro:IPR002616(Queuine/other tRNA-ribosyltransferase)|interpro:IPR004803(Queuine tRNA-ribosyltransferase)|interpro:IPR036511|rcsb pdb:6H42|rcsb pdb:6H45|reactome:R-HSA-6782315|go:"GO:0046872"(metal ion binding) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:0Z1Trg9nHJebKDjnOB6gBKvoMxA9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:7F8DFAD4C166C90F|rigid:SFBr9b6fdjERqpVHqepUasrYLj8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N6Y0 uniprotkb:P03431 intact:EBI-739895|uniprotkb:Q8NBX7|uniprotkb:Q96KH3|uniprotkb:Q9BYI8|uniprotkb:A8K7L6|uniprotkb:B2RCR9|ensembl:ENSP00000252597 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:usbp1_human(display_long)|uniprotkb:USHBP1(gene name)|psi-mi:USHBP1(display_short)|uniprotkb:MCC-2(gene name synonym)|uniprotkb:AIE-75-binding protein(gene name synonym)|uniprotkb:AIEBP(gene name synonym)|uniprotkb:MCC2(gene name synonym)|uniprotkb:Mutated in colon cancer protein 2(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548653|imex:IM-13585-237 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001284632.1|refseq:NP_114147.2|refseq:NP_001308346.1|ensembl:ENSG00000130307(gene)|ensembl:ENST00000252597(transcript)|go:"GO:0030165"(PDZ domain binding)|interpro:IPR019536|interpro:IPR040171 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vY1qx73Ju/z7WDu6k1kd10ZDVRo9606 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:A380A844586C672F|rigid:2cL7t0WA7XpgRL7SVGtNAp02CKo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N6Y0 uniprotkb:P03428 intact:EBI-739895|uniprotkb:Q8NBX7|uniprotkb:Q96KH3|uniprotkb:Q9BYI8|uniprotkb:A8K7L6|uniprotkb:B2RCR9|ensembl:ENSP00000252597 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:usbp1_human(display_long)|uniprotkb:USHBP1(gene name)|psi-mi:USHBP1(display_short)|uniprotkb:MCC-2(gene name synonym)|uniprotkb:AIE-75-binding protein(gene name synonym)|uniprotkb:AIEBP(gene name synonym)|uniprotkb:MCC2(gene name synonym)|uniprotkb:Mutated in colon cancer protein 2(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548664|imex:IM-13585-236 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001284632.1|refseq:NP_114147.2|refseq:NP_001308346.1|ensembl:ENSG00000130307(gene)|ensembl:ENST00000252597(transcript)|go:"GO:0030165"(PDZ domain binding)|interpro:IPR019536|interpro:IPR040171 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vY1qx73Ju/z7WDu6k1kd10ZDVRo9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:A5EA08478DBB73B4|rigid:4AIYYb63T/QagkkTSVlkHsfL0KY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:Q96IP2 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-2548681 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:q96ip2_human(display_long)|uniprotkb:MGC16075(gene name)|psi-mi:MGC16075(display_short)|uniprotkb:tcag7.1266(orf name) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548687|imex:IM-13585-250 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 - go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:YZ3WmhOd4xIMN/cYMNFfXbTbogE9606 intact-crc:9282FA518D3C3C3E|rigid:XVBjtEm+9m4clKpbnF1jpczpS2Y false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6P1W5 uniprotkb:P03428 intact:EBI-946029|uniprotkb:B3KVT1|uniprotkb:Q96IC8|ensembl:ENSP00000435634|uniprotkb:D3DPR3|uniprotkb:E9PJ76 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:ca094_human(display_long)|uniprotkb:C1orf94(gene name)|psi-mi:C1orf94(display_short) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548692|imex:IM-13585-238 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001128206.1|refseq:NP_116273.2|ensembl:ENSG00000142698(gene)|ensembl:ENST00000488417(transcript)|interpro:IPR031496 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:y1o4xWvTl2CBA1J7jsP7y8ZjLzM9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:99099F93D5B01ED9|rigid:KZERC1iNWCiJ0gUgEyt7F2dfuP0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96MC5 uniprotkb:P03466 intact:EBI-718468|uniprotkb:O00223|uniprotkb:O75769|uniprotkb:Q8IZ36|uniprotkb:Q96H25|ensembl:ENSP00000300006|ensembl:ENSP00000483858 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:merb1_human(display_long)|uniprotkb:BMERB1(gene name)|psi-mi:BMERB1(display_short)|uniprotkb:C16orf45(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548697|imex:IM-13585-114 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135941.1|refseq:NP_149978.1|ensembl:ENSG00000166780(gene)|ensembl:ENSG00000278823(gene)|ensembl:ENST00000300006(transcript)|ensembl:ENST00000615273(transcript)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0021822"(negative regulation of cell motility involved in cerebral cortex radial glia guided migration)|interpro:IPR022735|interpro:IPR040127 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:DSzrN8rIE3sJnAJeI9Bg9GuhClg9606 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:B5C6EE68ADDE3AA7|rigid:DPF0VsNM/pXaHwfm8bvuYbJDVR0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96DZ9 uniprotkb:P03428 intact:EBI-2548702|ensembl:ENSP00000344819|uniprotkb:E9PH91|uniprotkb:Q5PY48 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:cklf5_human(display_long)|uniprotkb:CMTM5(gene name)|psi-mi:CMTM5(display_short)|uniprotkb:CKLFSF5(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 5(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548741|imex:IM-13585-240 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000166091(gene)|ensembl:ENST00000339180(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045662"(negative regulation of myoblast differentiation)|interpro:IPR008253(Marvel)|mint:Q96DZ9|go:"GO:0006935"(chemotaxis)|refseq:NP_001032365.1|refseq:NP_612469.1|refseq:NP_001275673.1|refseq:NP_001275674.1|refseq:NP_001275675.1|refseq:XP_016876442.1|refseq:XP_016876443.1 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EGqSw7EqPjSoBwDYC7Td1f0PbCA9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:6A09A9F2AE2D10E5|rigid:IYCqziPwgU6BXi+bS91M6Ai0og0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03508 uniprotkb:Q96FJ2 intact:EBI-2547979|uniprotkb:A4GXG8|uniprotkb:Q20N33|uniprotkb:Q67266|uniprotkb:Q71QT4 intact:EBI-742371|uniprotkb:B2R5B4|ensembl:ENSP00000477310 psi-mi:nep_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:dyl2_human(display_long)|uniprotkb:DYNLL2(gene name)|psi-mi:DYNLL2(display_short)|uniprotkb:Dynein light chain LC8-type 2(gene name synonym)|uniprotkb:DLC2(gene name synonym)|uniprotkb:8 kDa dynein light chain b(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548746|imex:IM-13585-241 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)")|refseq:NP_040983.1|rcsb pdb:1PD3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823 go:"GO:0005813"(centrosome)|refseq:NP_542408.1|ensembl:ENSG00000264364(gene)|ensembl:ENST00000579991(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007017"(microtubule-based process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030286"(dynein complex)|go:"GO:0031475"(myosin V complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097542"(ciliary tip)|go:"GO:0097731"(9+0 non-motile cilium)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:Q96FJ2|rcsb pdb:2XQQ|rcsb pdb:3P8M|rcsb pdb:4D07|reactome:R-HSA-139910|reactome:R-HSA-141444|reactome:R-HSA-1632852|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5620924|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:xFUkgB+T3wkm4nwM67KuSUj1gP0211044 rogid:4RFpJF40RBja5mOvt/aCv3miiDU9606 intact-crc:AE957672D0F25330|rigid:qFeCzbeUS6JmjQeiED3x2FIkDNE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03466 uniprotkb:Q8TD10 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 intact:EBI-2548751|ensembl:ENSP00000333539|ensembl:ENSP00000379589|ensembl:ENSP00000444254|ensembl:ENSP00000506738|uniprotkb:Q7Z3J0|uniprotkb:Q8IV14|uniprotkb:D3DSA4 psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:mipo1_human(display_long)|uniprotkb:MIPOL1(gene name)|psi-mi:MIPOL1(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548774|imex:IM-13585-245 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 ensembl:ENSG00000151338(gene)|ensembl:ENST00000327441(transcript)|ensembl:ENST00000396294(transcript)|ensembl:ENST00000537471(transcript)|ensembl:ENST00000684589(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR026175|mint:Q8TD10|refseq:NP_001182225.1|refseq:NP_001182226.1|refseq:NP_620059.1|refseq:XP_016876492.1|refseq:XP_016876493.1|refseq:XP_016876494.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 rogid:X4gY7nzDtnrS2yil7QhmLH968Ug9606 intact-crc:B1666374600D31B7|rigid:gsMwfoEyVFuSUQqisawL1mnLAGA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:Q8TD10 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-2548751|ensembl:ENSP00000333539|ensembl:ENSP00000379589|ensembl:ENSP00000444254|ensembl:ENSP00000506738|uniprotkb:Q7Z3J0|uniprotkb:Q8IV14|uniprotkb:D3DSA4 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:mipo1_human(display_long)|uniprotkb:MIPOL1(gene name)|psi-mi:MIPOL1(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548779|imex:IM-13585-243 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 ensembl:ENSG00000151338(gene)|ensembl:ENST00000327441(transcript)|ensembl:ENST00000396294(transcript)|ensembl:ENST00000537471(transcript)|ensembl:ENST00000684589(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR026175|mint:Q8TD10|refseq:NP_001182225.1|refseq:NP_001182226.1|refseq:NP_620059.1|refseq:XP_016876492.1|refseq:XP_016876493.1|refseq:XP_016876494.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:X4gY7nzDtnrS2yil7QhmLH968Ug9606 intact-crc:883E2CDA8235DB94|rigid:jb0faIx6CKDoG2ifpctUbYtFq4k false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96D05 uniprotkb:P03433 intact:EBI-2548784|ensembl:ENSP00000362376 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:f241b_human(display_long)|uniprotkb:FAM241B(gene name)|psi-mi:FAM241B(display_short)|uniprotkb:C10orf35(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548792|imex:IM-13585-248 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171224(gene)|ensembl:ENST00000373279(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR027953|mint:Q96D05|refseq:XP_011537757.1|refseq:NP_660349.1|refseq:XP_005269663.1|refseq:XP_005269665.1|refseq:XP_016871325.1 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:2Iylns4G5knUSJCXAPnLUE9laUU9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:63B131EB62B962B4|rigid:zR41lbkTQYtMtFSmrQwL5Xg2ho0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N448 uniprotkb:P03428 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548797|imex:IM-13585-121 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:476953084BDA33BD|rigid:W+j/niRquChk1E85RwphYY6PiSg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N448 uniprotkb:P03452 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 intact:EBI-2548105|uniprotkb:A4GXH4|uniprotkb:Q20N38|uniprotkb:Q83964|uniprotkb:Q8JUU5 psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:hema_i34a1(display_long)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548802|imex:IM-13585-112 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:1RU7|rcsb pdb:1RVX|rcsb pdb:1RVZ|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-198933|go:"GO:0046761"(viral budding from plasma membrane)|refseq:NP_040980.1|interpro:IPR008980(Viral capsid/haemagglutinin protein)|interpro:IPR013828(Haemagglutinin, HA1 chain, alpha/beta region)|interpro:IPR000149(Haemagglutinin, influenza A/B virus type, HA1 chain)|interpro:IPR001364(Haemagglutinin, influenza A/B virus type, HA1/HA2 chain)|mint:P03452 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 rogid:gouXSFq22QLERoidFm6ju2SwoIE211044 intact-crc:F9DC4CFAC587BCF5|rigid:LWTmKu8koJbv7cQG/UXrBoI86MQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N448 uniprotkb:P03433 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548807|imex:IM-13585-81 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:BB7EE816F3941125|rigid:LTcZ2JwQu0C7r5i6GfD9qhkXzN4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:Q8N448 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548812|imex:IM-13585-113 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 intact-crc:4103F30B9E0D2726|rigid:d9NURcBACnfEgxOiAzCE93BstW8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N448 uniprotkb:P06821 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548817|imex:IM-13585-116 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 intact-crc:235FA5F4AFA27DDC|rigid:Gk+D7VDqtjmdDZtpQW/ciYqZIiY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N448 uniprotkb:P03496 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548822|imex:IM-13585-117 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:BC3EA29AE54E2098|rigid:5iOjaL5tE1RPN615jdu71KBMvSI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N448 uniprotkb:P03485 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548827|imex:IM-13585-119 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:FF7FD511F83730E2|rigid:h2RoiZJGyvOCjUx/Q68e/+4i/T4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N661 uniprotkb:P03433 intact:EBI-2548832|ensembl:ENSP00000321038 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:tm86b_human(display_long)|uniprotkb:Transmembrane protein 86B(gene name synonym)|uniprotkb:TMEM86B(gene name)|psi-mi:TMEM86B(display_short) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548841|imex:IM-13585-118 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000180089(gene)|ensembl:ENST00000327042(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016803"(ether hydrolase activity)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042802"(identical protein binding)|go:"GO:0046485"(ether lipid metabolic process)|go:"GO:0047408"(alkenylglycerophosphocholine hydrolase activity)|go:"GO:0047409"(alkenylglycerophosphoethanolamine hydrolase activity)|interpro:IPR012506(YhhN-like)|reactome:R-HSA-1482788|refseq:NP_776165.3 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:nJ3Q3F+uAiIKzzYIzaWRms9/a3s9606 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:648B7B5490016EC6|rigid:+NBBV2YYf73j5+4SsXfqwfXCzH8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N5I3 uniprotkb:P03428 intact:EBI-745755|uniprotkb:Q0P6D0|uniprotkb:Q8IU75|uniprotkb:Q8N3Q9|uniprotkb:A2A2X9|ensembl:ENSP00000324191 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:kcnrg_human(display_long)|uniprotkb:Protein CLLD4(gene name synonym)|uniprotkb:KCNRG(gene name)|psi-mi:KCNRG(display_short)|uniprotkb:CLLD4(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548846|imex:IM-13585-123 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775876.1|refseq:NP_955751.1|go:"GO:0051260"(protein homooligomerization)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|ensembl:ENSG00000198553(gene)|ensembl:ENST00000312942(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0042802"(identical protein binding) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Zl81okdqtLzwJC8HsHA+g9n7JXs9606 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:4D19B660815C3146|rigid:Cki0j/Lj6DbjdRjd7YJ90bKLtJE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03485 intact:EBI-2548851 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 - psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:c4am89_human(display_short)|psi-mi:EBI-2548851(display_long)|uniprotkb:NBPF22P(gene name)|psi-mi:NBPF22P(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548858|imex:IM-13585-125 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 uniprotkb:C4AM89(uniprot-removed-ac) go:"GO:0019048"(modulation by virus of host process) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 rogid:BzqVlUbqCzLHJTtyvjXTxaOm7Dc9606 intact-crc:3AEB53A12B641598|rigid:8KUzqcUmebGQQTBzgDwHqjzT2lI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:Q96EC8 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-751210|uniprotkb:Q5JP08|uniprotkb:B4E1U7|uniprotkb:G5E997|ensembl:ENSP00000417573 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:yipf6_human(display_long)|uniprotkb:YIP1 family member 6(gene name synonym)|uniprotkb:YIPF6(gene name)|psi-mi:YIPF6(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548863|imex:IM-13585-126 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 refseq:NP_776195.2|refseq:NP_001182143.1|ensembl:ENSG00000181704(gene)|ensembl:ENST00000462683(transcript)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0060576"(intestinal epithelial cell development)|interpro:IPR006977(Yip1 domain)|mint:Q96EC8|reactome:R-HSA-432722 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:mfHkmdPyX5lK/euzg8v1Ydikf5w9606 intact-crc:24F38525620D15D8|rigid:qWVcnPALPj5wo/ty9z4XLNiMLxE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:P0C7W6 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-2548868|ensembl:ENSP00000329860 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:cc172_human(display_long)|uniprotkb:CCDC172(gene name)|psi-mi:CCDC172(display_short)|uniprotkb:C10orf96(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548875|imex:IM-13585-249 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 refseq:NP_940917.1|ensembl:ENSG00000182645(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0097225"(sperm midpiece)|interpro:IPR029618|mint:P0C7W6|ensembl:ENST00000333254(transcript)|refseq:XP_016871695.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Fig. 2C, Supp. Fig. 3C, Supp. Table 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:JAaMYXob1bjFtiCvHmuzgCvq+FU9606 intact-crc:380037F58C8E9EB4|rigid:8DacTLQ/rQOfq9PxsnkMFcm2/U4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:P03452 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2548105|uniprotkb:A4GXH4|uniprotkb:Q20N38|uniprotkb:Q83964|uniprotkb:Q8JUU5 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:hema_i34a1(display_long)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603563|imex:IM-13585-132 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:1RU7|rcsb pdb:1RVX|rcsb pdb:1RVZ|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-198933|go:"GO:0046761"(viral budding from plasma membrane)|refseq:NP_040980.1|interpro:IPR008980(Viral capsid/haemagglutinin protein)|interpro:IPR013828(Haemagglutinin, HA1 chain, alpha/beta region)|interpro:IPR000149(Haemagglutinin, influenza A/B virus type, HA1 chain)|interpro:IPR001364(Haemagglutinin, influenza A/B virus type, HA1/HA2 chain)|mint:P03452 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:gouXSFq22QLERoidFm6ju2SwoIE211044 intact-crc:A793FAF620A74C78|rigid:btkSe7n5GVqGF1dcR75ZjcySOOg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03466 uniprotkb:P03452 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 intact:EBI-2548105|uniprotkb:A4GXH4|uniprotkb:Q20N38|uniprotkb:Q83964|uniprotkb:Q8JUU5 psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:hema_i34a1(display_long)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603567|imex:IM-13585-100 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:1RU7|rcsb pdb:1RVX|rcsb pdb:1RVZ|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-198933|go:"GO:0046761"(viral budding from plasma membrane)|refseq:NP_040980.1|interpro:IPR008980(Viral capsid/haemagglutinin protein)|interpro:IPR013828(Haemagglutinin, HA1 chain, alpha/beta region)|interpro:IPR000149(Haemagglutinin, influenza A/B virus type, HA1 chain)|interpro:IPR001364(Haemagglutinin, influenza A/B virus type, HA1/HA2 chain)|mint:P03452 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 rogid:gouXSFq22QLERoidFm6ju2SwoIE211044 intact-crc:4ADDA5BAB6722421|rigid:2t2EESRZlIfl5sdEpEiKbJIld+Y false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P03452 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2548105|uniprotkb:A4GXH4|uniprotkb:Q20N38|uniprotkb:Q83964|uniprotkb:Q8JUU5 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:hema_i34a1(display_long)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603572|imex:IM-13585-101 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:1RU7|rcsb pdb:1RVX|rcsb pdb:1RVZ|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-198933|go:"GO:0046761"(viral budding from plasma membrane)|refseq:NP_040980.1|interpro:IPR008980(Viral capsid/haemagglutinin protein)|interpro:IPR013828(Haemagglutinin, HA1 chain, alpha/beta region)|interpro:IPR000149(Haemagglutinin, influenza A/B virus type, HA1 chain)|interpro:IPR001364(Haemagglutinin, influenza A/B virus type, HA1/HA2 chain)|mint:P03452 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:gouXSFq22QLERoidFm6ju2SwoIE211044 intact-crc:27DB820D87406961|rigid:/KNmY8VpyLmP2V79YDc2vVL18uQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03485 uniprotkb:P03485 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603577|imex:IM-13585-83 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:159EFA61645D1FFB|rigid:Jcb4r6x/4Om0f5MThDH6u0pHhTY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06821 uniprotkb:P03485 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603581|imex:IM-13585-104 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:121E941FB8AAFCBF|rigid:uKSC2fCY7EWgmJy7iXU/QZwrev8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03468 uniprotkb:P03485 intact:EBI-2547744|uniprotkb:A4GXH6|uniprotkb:Q20N35|uniprotkb:Q84043|uniprotkb:Q8JUU4 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:nram_i34a1(display_long)|uniprotkb:NA(gene name)|psi-mi:NA(display_short) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603585|imex:IM-13585-96 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0046730"(induction by virus of host immune response)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:0055036"(virion membrane)|refseq:NP_040981.1|interpro:IPR001860(Glycoside hydrolase, family 34)|interpro:IPR033654|reactome:R-HSA-168275|reactome:R-HSA-168277|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-168255|interpro:IPR036278|rcsb pdb:6WZY|rcsb pdb:6X00 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:YVcAxjIk6bzrYuQKio0NfZB9PG4211044 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:92F35014E2D7A714|rigid:fHspULmGXFAFNfXSVyB+Z1Dznvg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03485 uniprotkb:P03466 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603589|imex:IM-13585-94 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:AB2FB682F8E4D67D|rigid:lLe2HygvNkmK9vRoKqXViEYo40A false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03508 uniprotkb:P03485 intact:EBI-2547979|uniprotkb:A4GXG8|uniprotkb:Q20N33|uniprotkb:Q67266|uniprotkb:Q71QT4 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:nep_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603593|imex:IM-13585-129 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)")|refseq:NP_040983.1|rcsb pdb:1PD3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:xFUkgB+T3wkm4nwM67KuSUj1gP0211044 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:062F5F9533786A35|rigid:s67c3KQ6Zd5xzVuV2Hj3ELzK/4I false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P03468 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2547744|uniprotkb:A4GXH6|uniprotkb:Q20N35|uniprotkb:Q84043|uniprotkb:Q8JUU4 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:nram_i34a1(display_long)|uniprotkb:NA(gene name)|psi-mi:NA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603597|imex:IM-13585-97 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0000139"(Golgi membrane)|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0046730"(induction by virus of host immune response)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:0055036"(virion membrane)|refseq:NP_040981.1|interpro:IPR001860(Glycoside hydrolase, family 34)|interpro:IPR033654|reactome:R-HSA-168275|reactome:R-HSA-168277|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-168255|interpro:IPR036278|rcsb pdb:6WZY|rcsb pdb:6X00 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:YVcAxjIk6bzrYuQKio0NfZB9PG4211044 intact-crc:53AB5A3B673B6C96|rigid:L16oi25uVR52L4V+G18a2hS7Yv0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03466 uniprotkb:P03466 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603601|imex:IM-13585-99 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:6BC266B26F591BE4|rigid:+aIT5dLDwPlZsviyIGmOxc/B064 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:P03466 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603605|imex:IM-13585-102 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:AFC1181DFC0079DC|rigid:jENuJlA2I9/rIvVOJeotJDvXz8I false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03452 uniprotkb:P03496 intact:EBI-2548105|uniprotkb:A4GXH4|uniprotkb:Q20N38|uniprotkb:Q83964|uniprotkb:Q8JUU5 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:hema_i34a1(display_long)|uniprotkb:HA(gene name)|psi-mi:HA(display_short) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603609|imex:IM-13585-98 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:1RU7|rcsb pdb:1RVX|rcsb pdb:1RVZ|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-198933|go:"GO:0046761"(viral budding from plasma membrane)|refseq:NP_040980.1|interpro:IPR008980(Viral capsid/haemagglutinin protein)|interpro:IPR013828(Haemagglutinin, HA1 chain, alpha/beta region)|interpro:IPR000149(Haemagglutinin, influenza A/B virus type, HA1 chain)|interpro:IPR001364(Haemagglutinin, influenza A/B virus type, HA1/HA2 chain)|mint:P03452 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:gouXSFq22QLERoidFm6ju2SwoIE211044 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:0A9A09F3F486D466|rigid:fEFKzh/8hSWpFBYFTIbBP8gJu40 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03508 uniprotkb:P03496 intact:EBI-2547979|uniprotkb:A4GXG8|uniprotkb:Q20N33|uniprotkb:Q67266|uniprotkb:Q71QT4 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:nep_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603613|imex:IM-13585-103 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)")|refseq:NP_040983.1|rcsb pdb:1PD3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:xFUkgB+T3wkm4nwM67KuSUj1gP0211044 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:12A4FB2442DB277C|rigid:4xX00Q3VxVQMsckbkIABTOGrdVQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:P03485 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603620|imex:IM-13585-95 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:60FC56C58064C7CC|rigid:HwYSsfjqChMtmiISsfayLQpoAZs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06821 uniprotkb:P03496 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603624|imex:IM-13585-105 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:069530AEC909B1F6|rigid:5k+t3lLJuZt7I8rBlmYOad0mL5k false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:P03468 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-2547744|uniprotkb:A4GXH6|uniprotkb:Q20N35|uniprotkb:Q84043|uniprotkb:Q8JUU4 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:nram_i34a1(display_long)|uniprotkb:NA(gene name)|psi-mi:NA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603628|imex:IM-13585-106 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0000139"(Golgi membrane)|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0046730"(induction by virus of host immune response)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:0055036"(virion membrane)|refseq:NP_040981.1|interpro:IPR001860(Glycoside hydrolase, family 34)|interpro:IPR033654|reactome:R-HSA-168275|reactome:R-HSA-168277|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-168255|interpro:IPR036278|rcsb pdb:6WZY|rcsb pdb:6X00 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:YVcAxjIk6bzrYuQKio0NfZB9PG4211044 intact-crc:3FF47C232F8A2330|rigid:PwZU4whOOs+/aH8AalscciUwsYI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03466 uniprotkb:P03496 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603632|imex:IM-13585-107 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:A68F00ECF28E63A5|rigid:DCxL7ut6DIf0oy3jKz1I89yJxRY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03496 uniprotkb:P03496 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603636|imex:IM-13585-141 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:83A364FB828BCFC2|rigid:LBwV9B4OEPzx2gpPm3HFbeSzb9U false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03508 uniprotkb:P03496 intact:EBI-2547979|uniprotkb:A4GXG8|uniprotkb:Q20N33|uniprotkb:Q67266|uniprotkb:Q71QT4 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:nep_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603640|imex:IM-13585-109 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)")|refseq:NP_040983.1|rcsb pdb:1PD3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:xFUkgB+T3wkm4nwM67KuSUj1gP0211044 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:12A4FB2442DB277C|rigid:4xX00Q3VxVQMsckbkIABTOGrdVQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:P03496 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603644|imex:IM-13585-108 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:EF76D965CB11DB3E|rigid:34GJQV4tybpXvTKDpZ1SxLu9/sM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P03496 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603648|imex:IM-13585-110 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:7C6510FCE2CB1B0F|rigid:ASaIc1UTER+Lj5lv117fokC9vL0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:P03496 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-2547442|uniprotkb:Q20N32|uniprotkb:Q67267|uniprotkb:Q71QT3 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:ns1_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603652|imex:IM-13585-111 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR000256("Influenza non-structural protein (NS1)")|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:2GX9|rcsb pdb:2ZKO|rcsb pdb:3L4Q|rcsb pdb:3O9Q|rcsb pdb:3O9R|rcsb pdb:3O9S|rcsb pdb:3O9T|rcsb pdb:3O9U|rcsb pdb:3RVC|rcsb pdb:5NT1|rcsb pdb:5NT2|refseq:NP_040984.1|reactome:R-HSA-168276|reactome:R-HSA-1169408|reactome:R-HSA-168315|reactome:R-HSA-168888|reactome:R-HSA-169131|reactome:R-HSA-192823|dip:DIP-29081N|reactome:R-HSA-5213460|reactome:R-HSA-9686347 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:W0UBADcb+1m7URzCs+MzRgb5ucU211044 intact-crc:67B25BB01DD996B0|rigid:jEbHA1Z6oZY38EwXoemryiHzhTY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03508 uniprotkb:P03428 intact:EBI-2547979|uniprotkb:A4GXG8|uniprotkb:Q20N33|uniprotkb:Q67266|uniprotkb:Q71QT4 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:nep_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603656|imex:IM-13585-251 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)")|refseq:NP_040983.1|rcsb pdb:1PD3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:xFUkgB+T3wkm4nwM67KuSUj1gP0211044 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:016152E0AEC53B49|rigid:bRfSYjs1WGiUMl6IiAQVpEu25oM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03485 uniprotkb:P03433 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603661|imex:IM-13585-135 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:6DC0E34E5C64464E|rigid:8p4LxMFRVpt3NK7s5C4yVq47oqY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:P06821 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2547404|uniprotkb:A4GXH7|uniprotkb:Q20N37|uniprotkb:Q5UAV4|uniprotkb:Q5UAV5|uniprotkb:Q5UAV6|uniprotkb:Q84105|uniprotkb:Q8JUU3 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:m2_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603665|imex:IM-13585-82 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0000139"(Golgi membrane)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019061"(uncoating of virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0005216"(ion channel activity)|refseq:NP_040979.2|interpro:IPR002089(Influenza virus matrix protein 2)|rcsb pdb:5DLM|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:1XFiejD1BqZtWcSHTDfC/JryB9s211044 intact-crc:9D941BBFF3DFE04D|rigid:I9U05CLILoM0FKNAgteyfOLlw60 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:P03468 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2547744|uniprotkb:A4GXH6|uniprotkb:Q20N35|uniprotkb:Q84043|uniprotkb:Q8JUU4 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:nram_i34a1(display_long)|uniprotkb:NA(gene name)|psi-mi:NA(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603669|imex:IM-13585-252 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0000139"(Golgi membrane)|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0046730"(induction by virus of host immune response)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:0055036"(virion membrane)|refseq:NP_040981.1|interpro:IPR001860(Glycoside hydrolase, family 34)|interpro:IPR033654|reactome:R-HSA-168275|reactome:R-HSA-168277|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168336|reactome:R-HSA-168874|reactome:R-HSA-192823|reactome:R-HSA-168255|interpro:IPR036278|rcsb pdb:6WZY|rcsb pdb:6X00 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:YVcAxjIk6bzrYuQKio0NfZB9PG4211044 intact-crc:67E5FDC86DC9AC98|rigid:8glX93StAZiNFOd/wEUOQQakoQc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:P03466 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603674|imex:IM-13585-253 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:AF31752C89E52B79|rigid:flmdKBx0IiPlalh+OaQ4L4Tb3tI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03508 uniprotkb:P03433 intact:EBI-2547979|uniprotkb:A4GXG8|uniprotkb:Q20N33|uniprotkb:Q67266|uniprotkb:Q71QT4 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:nep_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603678|imex:IM-13585-127 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)")|refseq:NP_040983.1|rcsb pdb:1PD3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:xFUkgB+T3wkm4nwM67KuSUj1gP0211044 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:89A5D035780D76C7|rigid:0L05On6Tkrmo0yf5wgcTJIg5tzk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03508 uniprotkb:P03433 intact:EBI-2547979|uniprotkb:A4GXG8|uniprotkb:Q20N33|uniprotkb:Q67266|uniprotkb:Q71QT4 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:nep_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603682|imex:IM-13585-128 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)")|refseq:NP_040983.1|rcsb pdb:1PD3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:xFUkgB+T3wkm4nwM67KuSUj1gP0211044 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:89A5D035780D76C7|rigid:0L05On6Tkrmo0yf5wgcTJIg5tzk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:P03433 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603686|imex:IM-13585-130 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:vmY21RjtALOteYkDRockgEeKLss211044 intact-crc:65011FC302673CC7|rigid:J1e2iSoZzv+7IJcLlBUKsvetObw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:P03431 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603690|imex:IM-13585-133 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:517BE04CCDC3865A|rigid:ynoxQqQMPp/5sEqNv8ToothsjbU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03433 uniprotkb:P03428 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603695|imex:IM-13585-131 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:4AACAB0032D10BE5|rigid:dJmQyMUNBbqGRWD9ERH+CUGeSBU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P03485 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2547543|uniprotkb:A4GXH8|uniprotkb:Q20N36|uniprotkb:Q77HF4 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:m1_i34a1(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603699|imex:IM-13585-134 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|rcsb pdb:1AA7|rcsb pdb:1EA3|rcsb pdb:1HHI|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:3VDX|rcsb pdb:4D9J|rcsb pdb:4IQ4|rcsb pdb:4ITV|rcsb pdb:4IVJ|rcsb pdb:4QES|rcsb pdb:4QF0|rcsb pdb:4QFF|rcsb pdb:5CQE|rcsb pdb:5E6I|rcsb pdb:5EUO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5TEZ|rcsb pdb:6Z5L|rcsb pdb:7JM3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823|refseq:NP_040978.1|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR036039|mint:P03485|interpro:IPR037533 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:gWIMPimD/aaWfUa43m5BvMABd2Y211044 intact-crc:FED32AD775BE867F|rigid:flIZFQgA69ETYt6BffJ3w5asLTk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P03466 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2547640|uniprotkb:Q20N34|uniprotkb:Q58NB3|uniprotkb:Q67228|uniprotkb:Q80AB4 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:ncap_i34a1(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603703|imex:IM-13585-136 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0031904"(endosome lumen)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)")|rcsb pdb:2BST|rcsb pdb:2WFS|rcsb pdb:4NQV|rcsb pdb:4ZDU|rcsb pdb:5NPZ|rcsb pdb:5NQ3|rcsb pdb:5V5O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168316|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|refseq:NP_040982.1|dip:DIP-43998N|mint:P03466 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:N04UBXG2kQhoSQNftH7+NFsPJPU211044 intact-crc:3C22BCB5A03FEB48|rigid:m/Uo6XjMm3uIcqU1+N+hFJWe9Ts false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P03508 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2547979|uniprotkb:A4GXG8|uniprotkb:Q20N33|uniprotkb:Q67266|uniprotkb:Q71QT4 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:nep_i34a1(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603707|imex:IM-13585-137 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)")|refseq:NP_040983.1|rcsb pdb:1PD3|reactome:R-HSA-168255|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192823 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:xFUkgB+T3wkm4nwM67KuSUj1gP0211044 intact-crc:1AB619AC51D7B6F6|rigid:FsbFympZWLRmZSB+BPgJf000RQk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P03431 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603711|imex:IM-13585-139 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 intact-crc:D85EF58F9F36423D|rigid:MnTWKJeWy04dkeu7yDghn6HA2kQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03431 uniprotkb:P03428 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603715|imex:IM-13585-138 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:345D284C13688AC5|rigid:XBGgBIQ5La977f/VQ4MTK8wKYQU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03428 uniprotkb:P03428 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 intact:EBI-2547475|uniprotkb:A4GXH0|uniprotkb:Q20N28|uniprotkb:Q8JUU8 psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:pb2_i34a1(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2603719|imex:IM-13585-140 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031904"(endosome lumen)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2ZTT|rcsb pdb:3A1G|rcsb pdb:3CW4|rcsb pdb:3WI0|rcsb pdb:3WI1|rcsb pdb:4ENF|rcsb pdb:4J2R|rcsb pdb:4U6O|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|refseq:NP_040987.1|dip:DIP-43997N|mint:P03428 psi-mi:"MI:0469"(intact) - - figure legend:Supp. Table 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 rogid:EYCipJeWIh6PGw28FsJgpxv6XXs211044 intact-crc:0EBA38D85FEE7CED|rigid:4PtiZQDcg8KlUrHNON2+91BDg4U false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0DOF5 uniprotkb:O43186 intact:EBI-2548903|uniprotkb:P03490|uniprotkb:Q1K9D8|uniprotkb:P63231 intact:EBI-748171|uniprotkb:Q0QD45|ensembl:ENSP00000221996|ensembl:ENSP00000445565 psi-mi:m2_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:crx_human(display_long)|uniprotkb:CRX(gene name)|psi-mi:CRX(display_short)|uniprotkb:CORD2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548930|imex:IM-13585-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:1MP6|rcsb pdb:2KIH|rcsb pdb:2KWX|rcsb pdb:2L0J|rcsb pdb:2RLF|go:"GO:0005216"(ion channel activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|rcsb pdb:2N70|rcsb pdb:4QK7|rcsb pdb:4QKC|rcsb pdb:4QKL|rcsb pdb:4QKM|rcsb pdb:5C02|interpro:IPR002089(Influenza virus matrix protein 2) refseq:NP_000545.1|ensembl:ENSG00000105392(gene)|ensembl:ENST00000221996(transcript)|ensembl:ENST00000539067(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050896"(response to stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:hxwAh+YjNu/gDNuRDdOIiYyW5pQ381517 rogid:v/bkO/0iLzq1Q2HtieWQQ40RF9M9606 intact-crc:881FCC37883CB87C|rigid:SiGkhNCZm0Y+SvGp1C89x7XqFZE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P02511 uniprotkb:Q67296 intact:EBI-739060|uniprotkb:O43416|uniprotkb:B0YIX0|uniprotkb:Q9UC37|uniprotkb:Q9UC38|uniprotkb:Q9UC39|uniprotkb:Q9UC40|uniprotkb:Q9UC41|ensembl:ENSP00000227251|ensembl:ENSP00000433560|ensembl:ENSP00000434247|ensembl:ENSP00000435931|ensembl:ENSP00000436051|ensembl:ENSP00000436089|ensembl:ENSP00000437149|ensembl:ENSP00000483554|ensembl:ENSP00000498735|ensembl:ENSP00000499082 intact:EBI-2548937|uniprotkb:Q1K9E4 psi-mi:cryab_human(display_long)|uniprotkb:CRYAB(gene name)|psi-mi:CRYAB(display_short)|uniprotkb:CRYA2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-27(gene name synonym)|uniprotkb:"Alpha(B)-crystallin"(gene name synonym)|uniprotkb:Rosenthal fiber component(gene name synonym)|uniprotkb:Heat shock protein beta-5(gene name synonym)|uniprotkb:HSPB5(gene name synonym) psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548951|imex:IM-13585-32 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109846(gene)|ensembl:ENST00000227251(transcript)|ensembl:ENST00000526180(transcript)|ensembl:ENST00000527899(transcript)|ensembl:ENST00000527950(transcript)|ensembl:ENST00000531198(transcript)|ensembl:ENST00000533475(transcript)|ensembl:ENST00000533879(transcript)|ensembl:ENST00000616970(transcript)|ensembl:ENST00000650687(transcript)|ensembl:ENST00000651164(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006936"(muscle contraction)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031430"(M band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037882|mint:P02511|rcsb pdb:2KLR|rcsb pdb:2N0K|rcsb pdb:2WJ7|rcsb pdb:2Y1Y|rcsb pdb:2Y1Z|rcsb pdb:2YGD|rcsb pdb:3J07|rcsb pdb:2Y22|rcsb pdb:3L1G|rcsb pdb:3SGM|rcsb pdb:3SGN|rcsb pdb:3SGO|rcsb pdb:3SGP|rcsb pdb:3SGR|rcsb pdb:3SGS|rcsb pdb:4M5S|rcsb pdb:4M5T|rcsb pdb:5VVV|rcsb pdb:6BP9|reactome:R-HSA-3371571|refseq:NP_001876.1|refseq:XP_011540910.1|refseq:NP_001276736.1|refseq:NP_001276737.1|dip:DIP-35017N interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 go:"GO:0019048"(modulation by virus of host process) crc64:AE08BED46B7849CB - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:495Z42oQhkAUdADrAEOKIC5oICo9606 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 intact-crc:11EBBD9EFFB17336|rigid:vOtcXS4M/sMjm07AEYYzaXI9eq4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14641 uniprotkb:P0DOF4 intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3 intact:EBI-2548962|uniprotkb:P03486|uniprotkb:P10919|uniprotkb:Q1K9D7|uniprotkb:P63233 psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short) psi-mi:m1_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2548988|imex:IM-13585-68 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR036039|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606 rogid:HeH3SZ6mulGeBKY5+Px7jYOSgk8381517 intact-crc:667605676C36F848|rigid:za2ARimByhY/OiA4RCOhh0axd7U false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14641 uniprotkb:P03495 intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549019|imex:IM-13585-50 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 intact-crc:E93DD380ADECF2BA|rigid:Xd3AYEqfHQ2qfavDBASt3sSckmc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:O14641 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549024|imex:IM-13585-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606 intact-crc:E0A2990DD67AB2FD|rigid:zldSu1I2iIDIpFl7AARij4c01Mo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q92997 uniprotkb:P0DOF4 intact:EBI-739789|uniprotkb:O14642|uniprotkb:Q13531|uniprotkb:Q8N5E9|uniprotkb:Q92607|uniprotkb:D3DNT0|intact:EBI-11081380|uniprotkb:B4E3E5|ensembl:ENSP00000316054 intact:EBI-2548962|uniprotkb:P03486|uniprotkb:P10919|uniprotkb:Q1K9D7|uniprotkb:P63233 psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym) psi-mi:m1_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549029|imex:IM-13585-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004414.3|dip:DIP-34509N|ensembl:ENSG00000161202(gene)|ensembl:ENST00000313143(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042493"|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q92997|rcsb pdb:6V7O|rcsb pdb:6ZC6|rcsb pdb:6ZC8|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324 go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR036039|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606 rogid:HeH3SZ6mulGeBKY5+Px7jYOSgk8381517 intact-crc:2838F06D669E93CF|rigid:XIHc/px2/+dlqdEUT411SQDm3hI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q92997 uniprotkb:Q67296 intact:EBI-739789|uniprotkb:O14642|uniprotkb:Q13531|uniprotkb:Q8N5E9|uniprotkb:Q92607|uniprotkb:D3DNT0|intact:EBI-11081380|uniprotkb:B4E3E5|ensembl:ENSP00000316054 intact:EBI-2548937|uniprotkb:Q1K9E4 psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym) psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549035|imex:IM-13585-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004414.3|dip:DIP-34509N|ensembl:ENSG00000161202(gene)|ensembl:ENST00000313143(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042493"|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q92997|rcsb pdb:6V7O|rcsb pdb:6ZC6|rcsb pdb:6ZC8|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324 interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 intact-crc:68AEA86A01A7CADC|rigid:tXtgKkBkyUsaFIS9kdqlrOf8rVI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q06547 uniprotkb:Q1K9E3 intact:EBI-618165|ensembl:ENSP00000220429|uniprotkb:Q06545|uniprotkb:Q12940|uniprotkb:Q12941|uniprotkb:Q12942|uniprotkb:Q8IYD0|uniprotkb:A8IE52 intact:EBI-2549040 psi-mi:gabp1_human(display_long)|uniprotkb:GABP subunit beta-2(gene name synonym)|uniprotkb:Transcription factor E4TF1-53(gene name synonym)|uniprotkb:Transcription factor E4TF1-47(gene name synonym)|uniprotkb:Nuclear respiratory factor 2(gene name synonym)|uniprotkb:GABPB1(gene name)|psi-mi:GABPB1(display_short)|uniprotkb:E4TF1B(gene name synonym)|uniprotkb:GABPB(gene name synonym)|uniprotkb:GABPB2(gene name synonym) psi-mi:rdrp_i72a2(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549053|imex:IM-13585-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104064(gene)|ensembl:ENST00000220429(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q06547|reactome:R-HSA-2151201|refseq:NP_002032.2|refseq:NP_005245.2|refseq:NP_057738.1|refseq:NP_057739.1|refseq:NP_852092.1|refseq:NP_001307839.1|refseq:XP_005254331.1|refseq:XP_016877542.1|dip:DIP-33979N go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003723"(RNA binding)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:JO5HOl2ohh7LmNIn5UyYNbGviYE9606 rogid:RGH5m1+2R60n47+FB8F9m1Lhngw381517 intact-crc:95B73A9D497AE502|rigid:UWjSgl+E/BzcpiAXbFjUBR+hOxE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q08379 uniprotkb:P03495 intact:EBI-618309|intact:EBI-28970132|ensembl:ENSP00000478799|uniprotkb:Q6GRM9|uniprotkb:Q9BRB0|uniprotkb:Q9NYF9|uniprotkb:A0A0C4DGS5|intact:EBI-11522202 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:goga2_human(display_long)|uniprotkb:GOLGA2(gene name)|psi-mi:GOLGA2(display_short)|uniprotkb:130 kDa cis-Golgi matrix protein(gene name synonym)|uniprotkb:GM130 autoantigen(gene name synonym)|uniprotkb:Golgin-95(gene name synonym) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549064|imex:IM-13585-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000167110(gene)|ensembl:ENST00000611957(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000922"(spindle pole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005874"(microtubule)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007030"(Golgi organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR024858|interpro:IPR043937|interpro:IPR043976|mint:Q08379|rcsb pdb:4REY|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|reactome:R-HSA-162658|reactome:R-HSA-204005|reactome:R-HSA-6807878|reactome:R-HSA-8862803|refseq:NP_004477.3|ensembl:ENSP00000478799|dip:DIP-34271N go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vIlRg4sJ2oBiARNnyerGMaVr5ZU9606 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 intact-crc:29C3EF315C845FCF|rigid:Q3JpNlggxGHzRrJt8hEhDpMJ7a8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P52294 uniprotkb:P06827 intact:EBI-358383|uniprotkb:Q9BQ56|uniprotkb:Q6IBQ9|intact:EBI-1058734|ensembl:ENSP00000343701|uniprotkb:D3DN93 intact:EBI-2549069|uniprotkb:Q1K9E0 psi-mi:ima5_human(display_long)|uniprotkb:KPNA1(gene name)|psi-mi:KPNA1(display_short)|uniprotkb:RCH2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-1(gene name synonym)|uniprotkb:SRP1-beta(gene name synonym)|uniprotkb:RAG cohort protein 2(gene name synonym)|uniprotkb:Nucleoprotein interactor 1(gene name synonym) psi-mi:ncap_i72a2(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549082|imex:IM-13585-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002255.3|ensembl:ENSG00000114030(gene)|ensembl:ENST00000344337(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014841"(skeletal muscle satellite cell proliferation)|go:"GO:0014901"(satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0030425"(dendrite)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52294|rcsb pdb:2JDQ|rcsb pdb:3TJ3|rcsb pdb:4B18|rcsb pdb:6WX9|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-162592|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180910|reactome:R-HSA-909733|reactome:R-HSA-9636249|dip:DIP-29296N|refseq:XP_005247494.1 go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)") go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:eha8sOMYqe0OC6eXBA4eJLLsKFs9606 rogid:M0A/sVYptP1pDs1fchqvmPrTyCI381517 intact-crc:AC8BDF6EBB1330D8|rigid:wLjLJHOkBgX3Bz31p8PmuimnPgw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06827 uniprotkb:O00505 intact:EBI-2549069|uniprotkb:Q1K9E0 intact:EBI-358297|intact:EBI-28976892|ensembl:ENSP00000261667|uniprotkb:O00191|uniprotkb:O43195|uniprotkb:Q96AA7|uniprotkb:Q5JVM9|intact:EBI-742146|uniprotkb:Q8IYQ9 psi-mi:ncap_i72a2(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:ima4_human(display_long)|uniprotkb:KPNA3(gene name)|psi-mi:KPNA3(display_short)|uniprotkb:QIP2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)|uniprotkb:SRP1-gamma(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549107|imex:IM-13585-44 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)") ensembl:ENSG00000102753(gene)|ensembl:ENST00000261667(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0043657"(host cell)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000225(Armadillo)|refseq:NP_002258.2|ensembl:ENSP00000261667|dip:DIP-27586N|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00505|reactome:R-HSA-1169408|reactome:R-HSA-168276 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:M0A/sVYptP1pDs1fchqvmPrTyCI381517 rogid:kx/oTYWMYG7dhwJHvr1POLD6FTU9606 intact-crc:B8ACB1569EF72396|rigid:y5XRNCNNMJJ22pjGqBV+FZH5mo0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P43360 uniprotkb:Q67296 intact:EBI-1045155|uniprotkb:A8IF93|uniprotkb:Q6NW44|ensembl:ENSP00000329199|ensembl:ENSP00000480637 intact:EBI-2548937|uniprotkb:Q1K9E4 psi-mi:maga6_human(display_long)|uniprotkb:MAGE-6 antigen(gene name synonym)|uniprotkb:MAGE3B antigen(gene name synonym)|uniprotkb:Cancer/testis antigen 1.6(gene name synonym)|uniprotkb:MAGEA6(gene name)|psi-mi:MAGEA6(display_short)|uniprotkb:MAGE6(gene name synonym) psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549112|imex:IM-13585-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005354.1|refseq:NP_787064.1|ensembl:ENSG00000197172(gene)|ensembl:ENST00000329342(transcript)|ensembl:ENST00000616035(transcript)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR030097|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899 interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Ag4IF8+k8aF+zuiB7NwjRrGGH6E9606 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 intact-crc:E5FBFCD1BE341AEB|rigid:0JtRFPcaPMLvay7w824hJ8fHP1E false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:P43364 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-739552|uniprotkb:Q5ETU4|uniprotkb:Q6ZRZ5|ensembl:ENSP00000347358 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:magab_human(display_long)|uniprotkb:MAGEA11(gene name)|psi-mi:MAGEA11(display_short)|uniprotkb:MAGE11(gene name synonym)|uniprotkb:MAGE-11 antigen(gene name synonym)|uniprotkb:Cancer/testis antigen 1.11(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549117|imex:IM-13585-77 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:NP_001011544.1|refseq:NP_005357.2|ensembl:ENSG00000185247(gene)|ensembl:ENST00000355220(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR030099|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:P43364|rcsb pdb:6WJH|refseq:XP_016885010.1|refseq:XP_016885011.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:S0eOQssWhZCbAvWQCub2H+zQmzs9606 intact-crc:C660C448B10E43E4|rigid:sZtXKC62OG9b9HOdBWJg1Y66uAQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P43365 uniprotkb:P03495 intact:EBI-749530|uniprotkb:Q9NSD3|intact:EBI-10178394|uniprotkb:Q6FHH8|ensembl:ENSP00000350592|ensembl:ENSP00000377447|ensembl:ENSP00000377478 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:magac_human(display_long)|uniprotkb:MAGE-12 antigen(gene name synonym)|uniprotkb:MAGE12F antigen(gene name synonym)|uniprotkb:Cancer/testis antigen 1.12(gene name synonym)|uniprotkb:MAGEA12(gene name)|psi-mi:MAGEA12(display_short)|uniprotkb:MAGE12(gene name synonym) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549123|imex:IM-13585-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159858.1|refseq:NP_001159859.1|refseq:NP_005358.2|ensembl:ENSG00000213401(gene)|ensembl:ENST00000357916(transcript)|ensembl:ENST00000393869(transcript)|ensembl:ENST00000393900(transcript)|interpro:IPR002190(MAGE protein)|interpro:IPR021072|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899 go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:3/Jxz2VsFOb67RWqWj3xbTrw3s49606 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 intact-crc:E8407C0B8DD8B777|rigid:HSARRrwyr5BU7ffLc9Ah9RQZuYs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P50222 uniprotkb:P0DOF4 intact:EBI-748397|uniprotkb:O75263|ensembl:ENSP00000262041|uniprotkb:Q9UPL6|uniprotkb:B2R8I7|intact:EBI-10172134|intact:EBI-11522964|intact:EBI-11750003|intact:EBI-12702266|uniprotkb:A4D127 intact:EBI-2548962|uniprotkb:P03486|uniprotkb:P10919|uniprotkb:Q1K9D7|uniprotkb:P63233 psi-mi:meox2_human(display_long)|uniprotkb:Mesenchyme homeobox 2(gene name synonym)|uniprotkb:Growth arrest-specific homeobox(gene name synonym)|uniprotkb:MEOX2(gene name)|psi-mi:MEOX2(display_short)|uniprotkb:GAX(gene name synonym)|uniprotkb:MOX2(gene name synonym) psi-mi:m1_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549129|imex:IM-13585-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106511(gene)|ensembl:ENST00000262041(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008015"(blood circulation)|go:"GO:0016607"(nuclear speck)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060173"(limb development)|go:"GO:0061053"(somite development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR042634|refseq:NP_005915.2 go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR036039|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:fMv0ruKikzQ3MC0PBvJ3pOAjW+U9606 rogid:HeH3SZ6mulGeBKY5+Px7jYOSgk8381517 intact-crc:7ED8BF529378A1AC|rigid:ZXpRBfBFoIUnpHvT+8s+oZ39JoI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06827 uniprotkb:P40692 intact:EBI-2549069|uniprotkb:Q1K9E0 intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790 psi-mi:ncap_i72a2(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549134|imex:IM-13585-38 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)") refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:M0A/sVYptP1pDs1fchqvmPrTyCI381517 rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606 intact-crc:82072CCD1C64723B|rigid:gooyJbXUBeIPFW//pPLpAB9xav0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q1K9E3 uniprotkb:Q16656 intact:EBI-2549040 intact:EBI-2547810|ensembl:ENSP00000223190|ensembl:ENSP00000376922|ensembl:ENSP00000376924|uniprotkb:Q15305|uniprotkb:A8K4C6|uniprotkb:B4DDV6|uniprotkb:Q96AN2 psi-mi:rdrp_i72a2(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:nrf1_human(display_long)|uniprotkb:NRF1(gene name)|psi-mi:NRF1(display_short)|uniprotkb:Alpha palindromic-binding protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549139|imex:IM-13585-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003723"(RNA binding)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype) ensembl:ENSG00000106459(gene)|ensembl:ENST00000223190(transcript)|ensembl:ENST00000393230(transcript)|ensembl:ENST00000393232(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070062"(extracellular exosome)|interpro:IPR019525|interpro:IPR019526|interpro:IPR039142|reactome:R-HSA-1989781|reactome:R-HSA-2151201|go:"GO:0005634"(nucleus)|refseq:NP_001280092.1|refseq:NP_001280093.1|refseq:NP_001035199.1|refseq:NP_005002.3|dip:DIP-56958N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:RGH5m1+2R60n47+FB8F9m1Lhngw381517 rogid:QvOptENwVbP2E1Z8ExTOmbx00NE9606 intact-crc:D2034190127BB7A2|rigid:cN9kaC+aWw8XMGGRLnD151BoaaQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:P45984 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-713568|uniprotkb:Q15708|uniprotkb:Q15710|uniprotkb:Q15711|uniprotkb:Q8N5C5|uniprotkb:A8K0S3|ensembl:ENSP00000394560|uniprotkb:B5M0B4|uniprotkb:B5BU66|uniprotkb:D3DWQ8|uniprotkb:D3DWQ9 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:mk09_human(display_long)|uniprotkb:Stress-activated protein kinase JNK2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 2(gene name synonym)|uniprotkb:JNK-55(gene name synonym)|uniprotkb:MAPK9(gene name)|psi-mi:MAPK9(display_short)|uniprotkb:JNK2(gene name synonym)|uniprotkb:PRKM9(gene name synonym)|uniprotkb:Stress-activated protein kinase 1a(gene name synonym)|uniprotkb:SAPK1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549144|imex:IM-13585-65 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:XP_006714954.1|refseq:NP_001128516.1|refseq:NP_002743.3|refseq:NP_620707.1|ensembl:ENSG00000050748(gene)|ensembl:ENST00000452135(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|refseq:NP_620708.1|refseq:NP_620709.1|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45984|rcsb pdb:3E7O|rcsb pdb:3NPC|rcsb pdb:7CML|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-450321|reactome:R-HSA-450341|refseq:NP_001295173.1|dip:DIP-270N|refseq:XP_016865127.1|refseq:XP_016865130.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:ljhZd5mc0kj5al142zo5Me2J26w9606 intact-crc:013C074F60B13F56|rigid:W/iMYmcO3LWnmguFb2ub7C+fU7w false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:P14373 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-719493|uniprotkb:A2BE15|uniprotkb:Q5RJA8|uniprotkb:Q5ST26|uniprotkb:Q6LA73|uniprotkb:Q6NXR9|uniprotkb:Q9BZY6|uniprotkb:Q9UJL3|ensembl:ENSP00000383555|ensembl:ENSP00000392787|ensembl:ENSP00000405229|ensembl:ENSP00000414793|ensembl:ENSP00000366404 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:tri27_human(display_long)|uniprotkb:TRIM27(gene name)|psi-mi:TRIM27(display_short)|uniprotkb:RNF76(gene name synonym)|uniprotkb:RFP(gene name synonym)|uniprotkb:Ret finger protein(gene name synonym)|uniprotkb:Tripartite motif-containing protein 27(gene name synonym)|uniprotkb:RING finger protein 76(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM27(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549149|imex:IM-13585-52 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:NP_006501.1|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090281"(negative regulation of calcium ion import)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035791|interpro:IPR043136|mint:P14373|reactome:R-HSA-3232142|reactome:R-HSA-9635465|reactome:R-HSA-8948751|ensembl:ENSG00000204713(gene)|ensembl:ENSG00000215641(gene)|ensembl:ENSG00000229006(gene)|ensembl:ENSG00000234495(gene)|ensembl:ENSG00000237071(gene)|ensembl:ENST00000377199(transcript)|ensembl:ENST00000400720(transcript)|ensembl:ENST00000431123(transcript)|ensembl:ENST00000435528(transcript)|ensembl:ENST00000437160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001650"(fibrillar center)|go:"GO:0002820"(negative regulation of adaptive immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045814"(negative regulation of gene expression, epigenetic) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:dsfH5OUghD8KSaTz1SFw9OYVTK49606 intact-crc:F5EBB2DA9298023D|rigid:mZifU6iQ+rVlCOD/JoQtwxjzPUM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8IUQ4 uniprotkb:Q1K9E3 intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421 intact:EBI-2549040 psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym) psi-mi:rdrp_i72a2(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549157|imex:IM-13585-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003723"(RNA binding)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606 rogid:RGH5m1+2R60n47+FB8F9m1Lhngw381517 intact-crc:3782A94F9BE88279|rigid:zfJ1WGB5rdKyzRIq5vgmy1YEd3I false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:O95793 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-358174|uniprotkb:Q6GTM4|uniprotkb:Q9H5B5|intact:EBI-366174|uniprotkb:Q9H5B4|uniprotkb:Q9Y3Q2|uniprotkb:A8K9Z4|ensembl:ENSP00000360922|uniprotkb:E1P5Y1|uniprotkb:E1P608|uniprotkb:Q5JW29 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:stau1_human(display_long)|uniprotkb:STAU1(gene name)|psi-mi:STAU1(display_short)|uniprotkb:STAU(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549163|imex:IM-13585-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:NP_001309856.1|refseq:NP_001309858.1|refseq:NP_001309859.1|refseq:NP_001032405.1|refseq:NP_004593.2|refseq:NP_059346.2|refseq:NP_059347.2|refseq:NP_059348.2|refseq:NP_001306063.1|refseq:NP_001306064.1|ensembl:ENSG00000124214(gene)|ensembl:ENST00000371856(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|refseq:XP_005260584.1|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044475|mint:O95793|rcsb pdb:4DKK|rcsb pdb:6HTU|rcsb pdb:6SDW|rcsb pdb:6SDY go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:uYjbWja/hG5M/3likHLe00Z2FgY9606 intact-crc:3D0790B2E8FD4AFF|rigid:RRj5kStMMhvAKe6SZP2a/oP5NJ4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:O75410 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-624237|uniprotkb:Q8IUJ3|uniprotkb:Q8IUJ4|uniprotkb:Q8IZG2|uniprotkb:Q8NEY7|uniprotkb:Q9UPP9|uniprotkb:B2RBD9|uniprotkb:Q6Y687|uniprotkb:Q86YG7|uniprotkb:Q8IUJ2|ensembl:ENSP00000321703|uniprotkb:D3DSX6|uniprotkb:B4E302 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:tacc1_human(display_long)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549168|imex:IM-13585-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 ensembl:ENSG00000147526(gene)|ensembl:ENST00000317827(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0051301"(cell division)|interpro:IPR007707(Transforming acidic coiled-coil-containing)|interpro:IPR039915|mint:O75410|go:"GO:0046966"(thyroid hormone receptor binding)|refseq:NP_001116296.1|refseq:NP_001139688.1|refseq:NP_006274.2|refseq:XP_005273682.1|refseq:XP_011542933.1|refseq:XP_011542934.1|refseq:XP_011542938.1|refseq:XP_016869261.1|refseq:XP_016869262.1|refseq:XP_016869263.1|refseq:XP_011542936.1|refseq:XP_011542939.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:o/GBmp6rt7B1GgH4gdBNaN5VrSc9606 intact-crc:6F8B6BD93A2CD57A|rigid:mRsOeIg3D7EQ2LAqFjOU97m3r6I false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:Q15633 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-978581|uniprotkb:Q12878|ensembl:ENSP00000266987|uniprotkb:Q9BRY2|uniprotkb:Q8WY32|uniprotkb:Q8WY33 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:trbp2_human(display_long)|uniprotkb:Trans-activation-responsive RNA-binding protein(gene name synonym)|uniprotkb:TARBP2(gene name)|psi-mi:TARBP2(display_short)|uniprotkb:TRBP(gene name synonym)|uniprotkb:TAR RNA-binding protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549180|imex:IM-13585-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N ensembl:ENSG00000139546(gene)|ensembl:ENST00000266987(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0016442"(RISC complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050689"(negative regulation of defense response to virus by host)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090065"(regulation of production of siRNA involved in RNA interference)|go:"GO:1903798"(regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR028605|interpro:IPR044469|interpro:IPR044470|interpro:IPR044471|mint:Q15633|rcsb pdb:2CPN|rcsb pdb:3ADL|rcsb pdb:3LLH|rcsb pdb:4WYQ|go:"GO:0016604"(nuclear body)|rcsb pdb:5N8L|rcsb pdb:5N8M|rcsb pdb:5ZAK|rcsb pdb:5ZAL|rcsb pdb:5ZAM|rcsb pdb:6ZBK|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_004169.3|refseq:NP_599150.1|refseq:NP_599151.2|refseq:XP_005269171.1|refseq:XP_005269172.1|dip:DIP-29665N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:2pOFQwyM408mDl2bYsKEb1yhFrE9606 intact-crc:55F5222A9D073CD3|rigid:tGfxDKxQgDxnjgn6g6syn7VSxMI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q99081 uniprotkb:Q1K9E3 intact:EBI-722877|uniprotkb:Q86VM2|ensembl:ENSP00000267811|ensembl:ENSP00000453737|uniprotkb:Q7Z3D9|uniprotkb:Q86TC1|uniprotkb:B4E1W1 intact:EBI-2549040 psi-mi:htf4_human(display_long)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:TCF12(gene name)|psi-mi:TCF12(display_short)|uniprotkb:HEB(gene name synonym)|uniprotkb:HTF4(gene name synonym)|uniprotkb:BHLHB20(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 20(gene name synonym) psi-mi:rdrp_i72a2(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549186|imex:IM-13585-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309086.1|refseq:NP_003196.1|refseq:NP_996919.1|refseq:NP_996920.1|refseq:NP_996921.1|refseq:NP_996923.1|ensembl:ENSG00000140262(gene)|ensembl:ENST00000267811(transcript)|ensembl:ENST00000557843(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|refseq:NP_001309080.1|refseq:NP_001293149.1|refseq:NP_001309088.1|refseq:NP_001309091.1|refseq:NP_001309094.1|dip:DIP-29403N|mint:Q99081|rcsb pdb:2KNH|rcsb pdb:4JOL|reactome:R-HSA-525793|reactome:R-HSA-8939236|reactome:R-HSA-9031628 go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003723"(RNA binding)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:XnBrmDaoz2JZQ66PCjfJsmaQ6209606 rogid:RGH5m1+2R60n47+FB8F9m1Lhngw381517 intact-crc:C03C81CFCE2DD05B|rigid:qsntalvMQhTtT2mj0d2rL2W70Bc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q99081 uniprotkb:Q67296 intact:EBI-722877|uniprotkb:Q86VM2|ensembl:ENSP00000267811|ensembl:ENSP00000453737|uniprotkb:Q7Z3D9|uniprotkb:Q86TC1|uniprotkb:B4E1W1 intact:EBI-2548937|uniprotkb:Q1K9E4 psi-mi:htf4_human(display_long)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:TCF12(gene name)|psi-mi:TCF12(display_short)|uniprotkb:HEB(gene name synonym)|uniprotkb:HTF4(gene name synonym)|uniprotkb:BHLHB20(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 20(gene name synonym) psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549191|imex:IM-13585-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309086.1|refseq:NP_003196.1|refseq:NP_996919.1|refseq:NP_996920.1|refseq:NP_996921.1|refseq:NP_996923.1|ensembl:ENSG00000140262(gene)|ensembl:ENST00000267811(transcript)|ensembl:ENST00000557843(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|refseq:NP_001309080.1|refseq:NP_001293149.1|refseq:NP_001309088.1|refseq:NP_001309091.1|refseq:NP_001309094.1|dip:DIP-29403N|mint:Q99081|rcsb pdb:2KNH|rcsb pdb:4JOL|reactome:R-HSA-525793|reactome:R-HSA-8939236|reactome:R-HSA-9031628 interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:XnBrmDaoz2JZQ66PCjfJsmaQ6209606 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 intact-crc:4D3750078ACDF202|rigid:oVZcJ7ib5KmtdTXXctYtBfKXzUA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q12800 uniprotkb:Q1K9E3 intact:EBI-717422|uniprotkb:Q12801|uniprotkb:Q9UD77|uniprotkb:A8K5E9|uniprotkb:Q9UD75|ensembl:ENSP00000257915 intact:EBI-2549040 psi-mi:tfcp2_human(display_long)|uniprotkb:Transcription factor LSF(gene name synonym)|uniprotkb:SAA3 enhancer factor(gene name synonym)|uniprotkb:TFCP2(gene name)|psi-mi:TFCP2(display_short)|uniprotkb:LSF(gene name synonym)|uniprotkb:SEF(gene name synonym) psi-mi:rdrp_i72a2(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549205|imex:IM-13585-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001166923.1|refseq:NP_001166924.1|refseq:NP_005644.2|ensembl:ENSG00000135457(gene)|ensembl:ENST00000257915(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037599|interpro:IPR041418|mint:Q12800 go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003723"(RNA binding)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:M7mQ08NDYxuawmUEKRgjSdIr+Og9606 rogid:RGH5m1+2R60n47+FB8F9m1Lhngw381517 intact-crc:CCC7AC606B4F3939|rigid:eWbJqLAlUE3ScRpZ8g+A5cBPuZs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P69258 uniprotkb:Q12800 intact:EBI-2549210|uniprotkb:P03503|uniprotkb:P03507|uniprotkb:Q1K9D6 intact:EBI-717422|uniprotkb:Q12801|uniprotkb:Q9UD77|uniprotkb:A8K5E9|uniprotkb:Q9UD75|ensembl:ENSP00000257915 psi-mi:nep_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:tfcp2_human(display_long)|uniprotkb:Transcription factor LSF(gene name synonym)|uniprotkb:SAA3 enhancer factor(gene name synonym)|uniprotkb:TFCP2(gene name)|psi-mi:TFCP2(display_short)|uniprotkb:LSF(gene name synonym)|uniprotkb:SEF(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549231|imex:IM-13585-67 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)") refseq:NP_001166923.1|refseq:NP_001166924.1|refseq:NP_005644.2|ensembl:ENSG00000135457(gene)|ensembl:ENST00000257915(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037599|interpro:IPR041418|mint:Q12800 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:GICBftr026aD4L9bQaG7RvXAv7s381517 rogid:M7mQ08NDYxuawmUEKRgjSdIr+Og9606 intact-crc:54022487281A1F9E|rigid:rTqr+/jTQ0Gj9yVBjvgRAN19vAM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q13077 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-359224|uniprotkb:Q658U1|uniprotkb:Q8NF13|uniprotkb:B4DJ77|ensembl:ENSP00000362994|ensembl:ENSP00000443183 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:traf1_human(display_long)|uniprotkb:TRAF1(gene name)|psi-mi:TRAF1(display_short)|uniprotkb:EBI6(gene name synonym)|uniprotkb:Epstein-Barr virus-induced protein 6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549236|imex:IM-13585-36 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:NP_001177874.1|refseq:NP_001177876.1|refseq:NP_005649.1|dip:DIP-27514N|ensembl:ENSG00000056558(gene)|ensembl:ENST00000373887(transcript)|ensembl:ENST00000540010(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|mint:Q13077|rcsb pdb:3M0D|rcsb pdb:5E1T|rcsb pdb:5H10|reactome:R-HSA-5357905|reactome:R-HSA-5357956 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:D51RV1gTNQQjGP978+uv98Hd3Lc9606 intact-crc:7264D4D61065E394|rigid:3AKe6IdxbjdxWDyTh3KvwLXfiH8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q12933 uniprotkb:Q67296 intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668 intact:EBI-2548937|uniprotkb:Q1K9E4 psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym) psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549241|imex:IM-13585-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 intact-crc:D417B2CBDF8AFB3B|rigid:10Y+gotv05Iilw4caSJaUfXMHbo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q15654 uniprotkb:Q1K9E3 intact:EBI-742327|uniprotkb:O15170|uniprotkb:O15275|uniprotkb:Q9BTB2|uniprotkb:Q9BUE5|uniprotkb:Q9BXP3|uniprotkb:Q9UNT4|uniprotkb:A4D2E7|ensembl:ENSP00000200457|uniprotkb:F2ZC07|uniprotkb:F2ZC08 intact:EBI-2549040 psi-mi:trip6_human(display_long)|uniprotkb:TRIP6(gene name)|psi-mi:TRIP6(display_short)|uniprotkb:OIP1(gene name synonym)|uniprotkb:Opa-interacting protein 1(gene name synonym)|uniprotkb:Zyxin-related protein 1(gene name synonym) psi-mi:rdrp_i72a2(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549246|imex:IM-13585-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003293.2|ensembl:ENSP00000200457|ensembl:ENST00000417475|ensembl:ENSP00000413817|ensembl:ENST00000437505|ensembl:ENSP00000410736|ensembl:ENST00000619988|ensembl:ENSP00000479865|ensembl:ENSG00000087077(gene)|ensembl:ENST00000200457(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q15654|rcsb pdb:1X61|rcsb pdb:2DLO|dip:DIP-34466N go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003723"(RNA binding)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:9Okf3b6sMMwX5awAx991GN9iSsQ9606 rogid:RGH5m1+2R60n47+FB8F9m1Lhngw381517 intact-crc:6EE58F69BEB4F1E1|rigid:k+0g2roe75KgOB5cy1xbXJTKVI8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:P63279 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-80168|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q59GX1|uniprotkb:Q86VB3|ensembl:ENSP00000324897|ensembl:ENSP00000348056|ensembl:ENSP00000380649|ensembl:ENSP00000380650|ensembl:ENSP00000384568|ensembl:ENSP00000455893|ensembl:ENSP00000456188|ensembl:ENSP00000457064|ensembl:ENSP00000490882|ensembl:ENSP00000385009|uniprotkb:D3DU69 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:ubc9_human(display_long)|uniprotkb:UBE2I(gene name)|psi-mi:UBE2I(display_short)|uniprotkb:p18(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:UBC9(gene name synonym)|uniprotkb:UBCE9(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549251|imex:IM-13585-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:NP_003336.1|refseq:NP_919235.1|refseq:NP_919236.1|refseq:NP_919237.1|ensembl:ENSG00000103275(gene)|rcsb pdb:5D2M|rcsb pdb:5F6D|rcsb pdb:5F6E|rcsb pdb:5F6U|rcsb pdb:5F6V|rcsb pdb:5F6W|rcsb pdb:5F6X|rcsb pdb:5F6Y|rcsb pdb:5FQ2|rcsb pdb:6SYF|reactome:R-HSA-1221632|reactome:R-HSA-196791|reactome:R-HSA-3065678|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000325437(transcript)|ensembl:ENST00000355803(transcript)|ensembl:ENST00000397514(transcript)|ensembl:ENST00000397515(transcript)|ensembl:ENST00000403747(transcript)|ensembl:ENST00000406620(transcript)|ensembl:ENST00000562470(transcript)|ensembl:ENST00000566587(transcript)|ensembl:ENST00000567074(transcript)|ensembl:ENST00000567383(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63279|rcsb pdb:1A3S|rcsb pdb:1KPS|rcsb pdb:1Z5Q|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2O25|rcsb pdb:2PE6|rcsb pdb:2PX9|rcsb pdb:2XWU|rcsb pdb:3A4S|rcsb pdb:3UIN|go:"GO:1990234"(transferase complex)|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4W5V|rcsb pdb:4Y1L|refseq:XP_016879129.1|dip:DIP-29078N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo9606 intact-crc:9F7F3A2571306830|rigid:g+fk3Po2pGmA3+p7Bj4FAtUotw4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0DOF5 uniprotkb:P24278 intact:EBI-2548903|uniprotkb:P03490|uniprotkb:Q1K9D8|uniprotkb:P63231 intact:EBI-739899|uniprotkb:Q8IYH9|uniprotkb:B3KUX6|ensembl:ENSP00000378204|ensembl:ENSP00000476746 psi-mi:m2_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:zbt25_human(display_long)|uniprotkb:ZBTB25(gene name)|psi-mi:ZBTB25(display_short)|uniprotkb:KUP(gene name synonym)|uniprotkb:ZNF46(gene name synonym)|uniprotkb:Zinc finger protein 46(gene name synonym)|uniprotkb:Zinc finger protein KUP(gene name synonym)|uniprotkb:C14orf51(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549256|imex:IM-13585-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:1MP6|rcsb pdb:2KIH|rcsb pdb:2KWX|rcsb pdb:2L0J|rcsb pdb:2RLF|go:"GO:0005216"(ion channel activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|rcsb pdb:2N70|rcsb pdb:4QK7|rcsb pdb:4QKC|rcsb pdb:4QKL|rcsb pdb:4QKM|rcsb pdb:5C02|interpro:IPR002089(Influenza virus matrix protein 2) refseq:NP_008908.2|ensembl:ENSG00000089775(gene)|ensembl:ENST00000394715(transcript)|ensembl:ENST00000608382(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P24278|refseq:NP_001291436.1|refseq:XP_011535445.1|refseq:XP_006720314.1|refseq:XP_006720315.1|refseq:XP_016877121.1|refseq:XP_016877122.1|refseq:XP_016877123.1|refseq:XP_016877124.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:hxwAh+YjNu/gDNuRDdOIiYyW5pQ381517 rogid:xi3bM5CoeXvVZNBOzaQlZdWU4ag9606 intact-crc:1C68B8A9A9C31B0F|rigid:Jgnn97oDEj59d1mKtBA/iOhElDc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06827 uniprotkb:P24278 intact:EBI-2549069|uniprotkb:Q1K9E0 intact:EBI-739899|uniprotkb:Q8IYH9|uniprotkb:B3KUX6|ensembl:ENSP00000378204|ensembl:ENSP00000476746 psi-mi:ncap_i72a2(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:zbt25_human(display_long)|uniprotkb:ZBTB25(gene name)|psi-mi:ZBTB25(display_short)|uniprotkb:KUP(gene name synonym)|uniprotkb:ZNF46(gene name synonym)|uniprotkb:Zinc finger protein 46(gene name synonym)|uniprotkb:Zinc finger protein KUP(gene name synonym)|uniprotkb:C14orf51(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549263|imex:IM-13585-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)") refseq:NP_008908.2|ensembl:ENSG00000089775(gene)|ensembl:ENST00000394715(transcript)|ensembl:ENST00000608382(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P24278|refseq:NP_001291436.1|refseq:XP_011535445.1|refseq:XP_006720314.1|refseq:XP_006720315.1|refseq:XP_016877121.1|refseq:XP_016877122.1|refseq:XP_016877123.1|refseq:XP_016877124.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:M0A/sVYptP1pDs1fchqvmPrTyCI381517 rogid:xi3bM5CoeXvVZNBOzaQlZdWU4ag9606 intact-crc:76C934A1835F482C|rigid:hyHFGqiujQN48o/lYHlLOb8Aoso false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13155 uniprotkb:P69258 intact:EBI-745226|uniprotkb:Q75MR1|uniprotkb:Q96CZ5|uniprotkb:Q9P1L2|ensembl:ENSP00000223029|uniprotkb:F8W950 intact:EBI-2549210|uniprotkb:P03503|uniprotkb:P03507|uniprotkb:Q1K9D6 psi-mi:aimp2_human(display_long)|uniprotkb:Protein JTV-1(gene name synonym)|uniprotkb:AIMP2(gene name)|psi-mi:AIMP2(display_short)|uniprotkb:PRO0992(orf name)|uniprotkb:JTV1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p38(gene name synonym) psi-mi:nep_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549268|imex:IM-13585-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006294.2|ensembl:ENSG00000106305(gene)|ensembl:ENST00000223029(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903632"(positive regulation of aminoacyl-tRNA ligase activity)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR031889|interpro:IPR036282|interpro:IPR041503|interpro:IPR042360|mint:Q13155|rcsb pdb:4DPG|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5Y6L|rcsb pdb:6ILD|rcsb pdb:6IY6|rcsb pdb:6JPV|rcsb pdb:6K39|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-34421N|refseq:NP_001313536.1 go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)") go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VEBmJjo6t3dBY6mKpmUyVLamJFQ9606 rogid:GICBftr026aD4L9bQaG7RvXAv7s381517 intact-crc:1797F386984A3C0C|rigid:i/LcRYK7suur31OiJ8ABf0aXiHM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q9H2G9 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-2548012|intact:EBI-28986503|ensembl:ENSP00000327541|ensembl:ENSP00000356782|uniprotkb:O15298|uniprotkb:Q5T531|uniprotkb:Q5T533|uniprotkb:Q9GZX4 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:go45_human(display_long)|uniprotkb:BLZF1(gene name)|psi-mi:BLZF1(display_short)|uniprotkb:JEM1(gene name synonym)|uniprotkb:Basic leucine zipper nuclear factor 1(gene name synonym)|uniprotkb:JEM-1(gene name synonym)|uniprotkb:p45 basic leucine-zipper nuclear factor(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549275|imex:IM-13585-69 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:XP_011508394.1|ensembl:ENSG00000117475(gene)|ensembl:ENST00000329281(transcript)|ensembl:ENST00000367808(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007030"(Golgi organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|interpro:IPR013183(Protein of unknown function DUF1721, fungi)|interpro:IPR027095|mint:Q9H2G9|reactome:R-HSA-162658|refseq:NP_003657.1|ensembl:ENSP00000327541|ensembl:ENST00000367807|ensembl:ENSP00000356781|ensembl:ENSP00000356782|refseq:NP_001307901.1|refseq:NP_001307902.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:FqMAghbeSRbqLmtaKELM5JZ+H3s9606 intact-crc:6739D23E56EBDACF|rigid:PeGiVYWyt8xaU0OB2s6/pEHAhbs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:O14503 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-711810|uniprotkb:Q96TD3|ensembl:ENSP00000256495 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:bhe40_human(display_long)|uniprotkb:BHLHE40(gene name)|psi-mi:BHLHE40(display_short)|uniprotkb:Differentially expressed in chondrocytes protein 1(gene name synonym)|uniprotkb:Enhancer-of-split and hairy-related protein 2(gene name synonym)|uniprotkb:Stimulated by retinoic acid gene 13 protein(gene name synonym)|uniprotkb:BHLHB2(gene name synonym)|uniprotkb:DEC1(gene name synonym)|uniprotkb:SHARP2(gene name synonym)|uniprotkb:STRA13(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549280|imex:IM-13585-55 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N ensembl:ENSG00000134107(gene)|ensembl:ENST00000256495(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_003661.1|dip:DIP-36698N|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:O14503|reactome:R-HSA-1368108 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:JZrZ1Yo2PF33s9Lf8rLTHCqoptk9606 intact-crc:D21161DFE1142037|rigid:5hLPfIO1I+Epyl9CTJKVCi1scYc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:O14503 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-711810|uniprotkb:Q96TD3|ensembl:ENSP00000256495 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:bhe40_human(display_long)|uniprotkb:BHLHE40(gene name)|psi-mi:BHLHE40(display_short)|uniprotkb:Differentially expressed in chondrocytes protein 1(gene name synonym)|uniprotkb:Enhancer-of-split and hairy-related protein 2(gene name synonym)|uniprotkb:Stimulated by retinoic acid gene 13 protein(gene name synonym)|uniprotkb:BHLHB2(gene name synonym)|uniprotkb:DEC1(gene name synonym)|uniprotkb:SHARP2(gene name synonym)|uniprotkb:STRA13(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549285|imex:IM-13585-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 ensembl:ENSG00000134107(gene)|ensembl:ENST00000256495(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043426"(MRF binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_003661.1|dip:DIP-36698N|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:O14503|reactome:R-HSA-1368108 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:JZrZ1Yo2PF33s9Lf8rLTHCqoptk9606 intact-crc:DB8E2B529A826070|rigid:BR3l3WOsw2s+b6oeFQhAy+53uLU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O75569 uniprotkb:P03495 intact:EBI-713955|ensembl:ENSP00000318176|uniprotkb:Q53G24|uniprotkb:Q6X7T5|uniprotkb:Q8NDK4|uniprotkb:A8K3I6 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:prkra_human(display_long)|uniprotkb:Protein activator of the interferon-induced protein kinase(gene name synonym)|uniprotkb:PKR-associated protein X(gene name synonym)|uniprotkb:PKR-associating protein X(gene name synonym)|uniprotkb:HSD-14(orf name)|uniprotkb:PRKRA(gene name)|psi-mi:PRKRA(display_short)|uniprotkb:RAX(gene name synonym)|uniprotkb:PACT(gene name synonym)|uniprotkb:HSD14(orf name)|uniprotkb:Protein kinase, interferon-inducible double-stranded RNA-dependent activator(gene name synonym) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549290|imex:IM-13585-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008047"(enzyme activator activity)|ensembl:ENSG00000180228(gene)|ensembl:ENST00000325748(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR033363|interpro:IPR044465|interpro:IPR044466|interpro:IPR044467|mint:O75569|rcsb pdb:2DIX|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_001132989.1|refseq:NP_001132990.1|refseq:NP_003681.1|dip:DIP-41809N go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:tZfziopZlC+1d3De97G3kDY+Tog9606 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 intact-crc:E00C42CC21ED9B4D|rigid:wz9odpc7PC6CKJu0ZTwKysPyeuA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8ND90 uniprotkb:Q67296 intact:EBI-302345|uniprotkb:O95144|uniprotkb:Q8NG07|ensembl:ENSP00000318914|uniprotkb:A8K4L5 intact:EBI-2548937|uniprotkb:Q1K9E4 psi-mi:pnma1_human(display_long)|uniprotkb:PNMA1(gene name)|psi-mi:PNMA1(display_short)|uniprotkb:MA1(gene name synonym)|uniprotkb:Neuron- and testis-specific protein 1(gene name synonym)|uniprotkb:37 kDa neuronal protein(gene name synonym) psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549297|imex:IM-13585-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006020.4|ensembl:ENSG00000176903(gene)|ensembl:ENST00000316836(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR026523|interpro:IPR026528|mint:Q8ND90 interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:/lx3CB7d/dv4xIgWQrCETPA0Qcw9606 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 intact-crc:D40E41C7E7B51FE7|rigid:wD6xV2MzVSq/M1ornq7EIqjiRyI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y5V3 uniprotkb:P06827 intact:EBI-716006|uniprotkb:Q5VSH6|uniprotkb:Q8IZ84|uniprotkb:Q8WY92|uniprotkb:Q9H352|uniprotkb:Q9HBT4|uniprotkb:Q9UF36|ensembl:ENSP00000325333|ensembl:ENSP00000364874|ensembl:ENSP00000364927 intact:EBI-2549069|uniprotkb:Q1K9E0 psi-mi:magd1_human(display_long)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:MAGE tumor antigen CCF(gene name synonym)|uniprotkb:MAGED1(gene name)|psi-mi:MAGED1(display_short)|uniprotkb:NRAGE(gene name synonym)|uniprotkb:PRO2292(orf name)|uniprotkb:PP2250(orf name) psi-mi:ncap_i72a2(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549302|imex:IM-13585-48 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001005332.1|refseq:NP_001005333.1|refseq:NP_008917.3|ensembl:ENSP00000325333|ensembl:ENST00000375695|ensembl:ENSP00000364847|ensembl:ENSP00000364874|ensembl:ENSP00000364927|refseq:XP_011529137.1|refseq:XP_016885467.1|refseq:XP_016885468.1|refseq:XP_016885469.1|ensembl:ENSG00000179222(gene)|ensembl:ENST00000326587(transcript)|ensembl:ENST00000375722(transcript)|ensembl:ENST00000375772(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9Y5V3|reactome:R-HSA-193648|reactome:R-HSA-418889 go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)") go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:UTg0r4zGMXfTZqBN4SFmgu6IukI9606 rogid:M0A/sVYptP1pDs1fchqvmPrTyCI381517 intact-crc:036218060CA408AC|rigid:Hw9/izWTqFgLb9sE1MW7FL745Vk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P51116 uniprotkb:Q1K9E3 intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113 intact:EBI-2549040 psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym) psi-mi:rdrp_i72a2(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549308|imex:IM-13585-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003723"(RNA binding)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606 rogid:RGH5m1+2R60n47+FB8F9m1Lhngw381517 intact-crc:371640C12C1A6B0E|rigid:dwgj4tWua/UHXv3nAP9hYs8Li0g false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O43889 uniprotkb:P0DOF5 intact:EBI-625002|uniprotkb:O14671|uniprotkb:O14919|uniprotkb:Q96GK8|uniprotkb:Q9H2W3|uniprotkb:Q9UE77|ensembl:ENSP00000342136|uniprotkb:D0PTW6|uniprotkb:Q5TCV1 intact:EBI-2548903|uniprotkb:P03490|uniprotkb:Q1K9D8|uniprotkb:P63231 psi-mi:creb3_human(display_long)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Leucine zipper protein(gene name synonym) psi-mi:m2_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549313|imex:IM-13585-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006935"(chemotaxis)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019043"(establishment of viral latency)|go:"GO:0019046"(release from viral latency)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029808|mint:O43889|reactome:R-HSA-8874211|go:"GO:0035497"(cAMP response element binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043025"(neuronal cell body)|refseq:NP_006359.3|dip:DIP-33935N rcsb pdb:1MP6|rcsb pdb:2KIH|rcsb pdb:2KWX|rcsb pdb:2L0J|rcsb pdb:2RLF|go:"GO:0005216"(ion channel activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|rcsb pdb:2N70|rcsb pdb:4QK7|rcsb pdb:4QKC|rcsb pdb:4QKL|rcsb pdb:4QKM|rcsb pdb:5C02|interpro:IPR002089(Influenza virus matrix protein 2) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2018/04/06 rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606 rogid:hxwAh+YjNu/gDNuRDdOIiYyW5pQ381517 intact-crc:A924DC26E235B413|rigid:xKlu943ZEDwcldDaX/tVDSncSQ8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:O75525 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-722504|uniprotkb:Q6NUL8|uniprotkb:Q9UPA8|ensembl:ENSP00000348108 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:khdr3_human(display_long)|uniprotkb:Sam68-like mammalian protein 2(gene name synonym)|uniprotkb:Sam68-like phosphotyrosine protein(gene name synonym)|uniprotkb:RNA-binding protein T-Star(gene name synonym)|uniprotkb:KHDRBS3(gene name)|psi-mi:KHDRBS3(display_short)|uniprotkb:SALP(gene name synonym)|uniprotkb:SLM2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549319|imex:IM-13585-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:NP_006549.1|ensembl:ENSG00000131773(gene)|ensembl:ENST00000355849(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:O75525|rcsb pdb:5EL3|rcsb pdb:5ELR|rcsb pdb:5ELS|rcsb pdb:5ELT|rcsb pdb:5EMO|reactome:R-HSA-8849468 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:9ZoB3JVp0Q9nxeFRsmWhNThzWoE9606 intact-crc:8D12905FA9AC4A05|rigid:eawblx5r4FG6Z2LOyfYRbH9DroU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:O95639 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-725860|uniprotkb:Q86TF8|uniprotkb:Q9BTW6|uniprotkb:Q6FGE6|uniprotkb:D6W5S8|ensembl:ENSP00000292476 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:cpsf4_human(display_long)|uniprotkb:Cleavage and polyadenylation specificity factor 30 kDa subunit(gene name synonym)|uniprotkb:NS1 effector domain-binding protein 1(gene name synonym)|uniprotkb:No arches homolog(gene name synonym)|uniprotkb:CPSF4(gene name)|psi-mi:CPSF4(display_short)|uniprotkb:CPSF30(gene name synonym)|uniprotkb:NAR(gene name synonym)|uniprotkb:NEB1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549324|imex:IM-13585-60 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:NP_001075028.1|refseq:NP_006684.1|refseq:NP_001305089.1|refseq:NP_001305090.1|refseq:NP_001305091.1|ensembl:ENSG00000160917(gene)|ensembl:ENST00000292476(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036855|interpro:IPR036875|interpro:IPR041686|mint:O95639|rcsb pdb:2D9N|rcsb pdb:2RHK|rcsb pdb:6DNH|rcsb pdb:6FBS|rcsb pdb:6FUW|rcsb pdb:6URG|rcsb pdb:6URO|rcsb pdb:7K95|reactome:R-HSA-159231|reactome:R-HSA-168315|reactome:R-HSA-6784531|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|dip:DIP-48675N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:CTNuFmbdKiPNvBJPEHoLi7WvoYM9606 intact-crc:BA8CEAC7C1AB7E36|rigid:DhbmGaLYSJWUwmqLmTrso9JG+wA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q1K9E3 uniprotkb:Q93062 intact:EBI-2549040 intact:EBI-740322|uniprotkb:Q92516|uniprotkb:Q92517|uniprotkb:Q92518|uniprotkb:Q96J26|uniprotkb:D3DSU9|ensembl:ENSP00000318102|ensembl:ENSP00000380486 psi-mi:rdrp_i72a2(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:rbpms_human(display_long)|uniprotkb:RBPMS(gene name)|psi-mi:RBPMS(display_short)|uniprotkb:HERMES(gene name synonym)|uniprotkb:Heart and RRM expressed sequence(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549329|imex:IM-13585-42 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003723"(RNA binding)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype) refseq:NP_001008710.1|refseq:NP_001008711.1|refseq:NP_001008712.1|refseq:NP_006858.1|ensembl:ENSG00000157110(gene)|ensembl:ENST00000320203(transcript)|ensembl:ENST00000397323(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q93062|rcsb pdb:1BNY|rcsb pdb:5CYJ|rcsb pdb:5DET|refseq:XP_016868475.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:RGH5m1+2R60n47+FB8F9m1Lhngw381517 rogid:3PsLJDzqs+19eVFeQlN+yLielYM9606 intact-crc:9A9F83C7F09005B8|rigid:Du8JWu9gOnZz4ZgC5oVbkPpUReU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q93062 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-740322|uniprotkb:Q92516|uniprotkb:Q92517|uniprotkb:Q92518|uniprotkb:Q96J26|uniprotkb:D3DSU9|ensembl:ENSP00000318102|ensembl:ENSP00000380486 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:rbpms_human(display_long)|uniprotkb:RBPMS(gene name)|psi-mi:RBPMS(display_short)|uniprotkb:HERMES(gene name synonym)|uniprotkb:Heart and RRM expressed sequence(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549334|imex:IM-13585-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:NP_001008710.1|refseq:NP_001008711.1|refseq:NP_001008712.1|refseq:NP_006858.1|ensembl:ENSG00000157110(gene)|ensembl:ENST00000320203(transcript)|ensembl:ENST00000397323(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q93062|rcsb pdb:1BNY|rcsb pdb:5CYJ|rcsb pdb:5DET|refseq:XP_016868475.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:3PsLJDzqs+19eVFeQlN+yLielYM9606 intact-crc:1794520FB47027E1|rigid:fLQdXWZQjyQkudxStnJsNdWvdyw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q96B26 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-371922|uniprotkb:O43480|uniprotkb:Q5TBA5|ensembl:ENSP00000374354 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:exos8_human(display_long)|uniprotkb:OIP2(gene name synonym)|uniprotkb:RRP43(gene name synonym)|uniprotkb:EXOSC8(gene name)|psi-mi:EXOSC8(display_short)|uniprotkb:Ribosomal RNA-processing protein 43(gene name synonym)|uniprotkb:Exosome component 8(gene name synonym)|uniprotkb:p9(gene name synonym)|uniprotkb:Opa-interacting protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549339|imex:IM-13585-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:NP_852480.1|ensembl:ENSG00000120699(gene)|ensembl:ENST00000389704(transcript)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034473"(U1 snRNA 3'-end processing)|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0034476"(U5 snRNA 3'-end processing)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071042"(nuclear polyadenylation-dependent mRNA catabolic process)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR020568|interpro:IPR027408|interpro:IPR033196|go:"GO:0005829"(cytosol)|mint:Q96B26|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|interpro:IPR036345|dip:DIP-31133N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:y/cReHiPMubzNruyETohBjbRick9606 intact-crc:D61AF150486AF095|rigid:xUudJFooSOtjYjPwTyl3hE/2SfQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:Q9UL40 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-2462313|uniprotkb:B7Z367|uniprotkb:Q68CV9|uniprotkb:Q6ZMW1|ensembl:ENSP00000350869 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:zn346_human(display_long)|uniprotkb:ZNF346(gene name)|psi-mi:ZNF346(display_short)|uniprotkb:JAZ(gene name synonym)|uniprotkb:Just another zinc finger protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549352|imex:IM-13585-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:NP_001295142.1|refseq:NP_001295143.1|refseq:NP_001295148.1|refseq:NP_001295152.1|refseq:NP_036411.1|refseq:XP_016864784.1|refseq:XP_016864785.1|ensembl:ENSG00000113761(gene)|ensembl:ENST00000358149(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0035198"(miRNA binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|rcsb pdb:2MKD|rcsb pdb:2MKN go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:bK/y4NYSSsa1tcNjtbmsEmkSp7Q9606 intact-crc:40842D2F9EC0CC0D|rigid:VDlsXucb0HsK802Z85srwUeZIYw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06827 uniprotkb:O60684 intact:EBI-2549069|uniprotkb:Q1K9E0 intact:EBI-359923|uniprotkb:Q5VVU3|uniprotkb:B2RDC7|ensembl:ENSP00000362728|uniprotkb:D3DPP5 psi-mi:ncap_i72a2(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:ima7_human(display_long)|uniprotkb:KPNA6(gene name)|psi-mi:KPNA6(display_short)|uniprotkb:IPOA7(gene name synonym)|uniprotkb:Karyopherin subunit alpha-6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549370|imex:IM-13585-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)") refseq:NP_036448.1|ensembl:ENSG00000025800(gene)|ensembl:ENST00000373625(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0019079"(viral genome replication)|go:"GO:0030682"(mitigation of host defenses by symbiont)|go:"GO:0043657"(host cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O60684|rcsb pdb:4UAD|dip:DIP-27609N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:M0A/sVYptP1pDs1fchqvmPrTyCI381517 rogid:3NsSIcE6BHIqYlvfGRolUKD/5uc9606 intact-crc:3915AA8FD71BA1E1|rigid:gOqxnFDBZg8nPZBvo/wiiwZ7yTw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y6X0 uniprotkb:P0DOF5 intact:EBI-2548259|intact:EBI-28969274|ensembl:ENSP00000497406|ensembl:ENSP00000502995|ensembl:ENSP00000503094|ensembl:ENSP00000503656|ensembl:ENSP00000504398|uniprotkb:A6H8W5|uniprotkb:Q9UEF3|uniprotkb:Q6P6C3 intact:EBI-2548903|uniprotkb:P03490|uniprotkb:Q1K9D8|uniprotkb:P63231 psi-mi:setbp_human(display_long)|uniprotkb:SETBP1(gene name)|psi-mi:SETBP1(display_short)|uniprotkb:KIAA0437(gene name synonym) psi-mi:m2_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549375|imex:IM-13585-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152217(gene)|ensembl:ENST00000649279(transcript)|ensembl:ENST00000677068(transcript)|ensembl:ENST00000677077(transcript)|ensembl:ENST00000677130(transcript)|ensembl:ENST00000678152(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|interpro:IPR017956|ensembl:ENST00000426838|ensembl:ENSP00000390687|ensembl:ENSP00000497406|ensembl:ENSP00000504398|ensembl:ENSP00000503656|ensembl:ENSP00000503094|ensembl:ENSP00000502995|refseq:NP_001123582.1|refseq:NP_056374.2 rcsb pdb:1MP6|rcsb pdb:2KIH|rcsb pdb:2KWX|rcsb pdb:2L0J|rcsb pdb:2RLF|go:"GO:0005216"(ion channel activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|rcsb pdb:2N70|rcsb pdb:4QK7|rcsb pdb:4QKC|rcsb pdb:4QKL|rcsb pdb:4QKM|rcsb pdb:5C02|interpro:IPR002089(Influenza virus matrix protein 2) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:bPLw8rppZYzLANH100jgHI5yfhI9606 rogid:hxwAh+YjNu/gDNuRDdOIiYyW5pQ381517 intact-crc:CE76D9B6DAB9A0FB|rigid:LWdmqOYdBB1u431FTjfLJDQ0kys false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H190 uniprotkb:P0DOF4 intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013 intact:EBI-2548962|uniprotkb:P03486|uniprotkb:P10919|uniprotkb:Q1K9D7|uniprotkb:P63233 psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym) psi-mi:m1_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549380|imex:IM-13585-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript) go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR036039|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606 rogid:HeH3SZ6mulGeBKY5+Px7jYOSgk8381517 intact-crc:E52D19361805C8B1|rigid:nAhuoP5fhEqGDyA3a4ricJ6TTXE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:Q9H190 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-742426|ensembl:ENSP00000371233|uniprotkb:O95892|uniprotkb:Q5W0X1|uniprotkb:Q9BZ42|uniprotkb:Q9H567|uniprotkb:Q9NRY8|intact:EBI-28983470|ensembl:ENSP00000342935|ensembl:ENSP00000354013 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:sdcb2_human(display_long)|uniprotkb:Similar to TACIP18(gene name synonym)|uniprotkb:SDCBP2(gene name)|psi-mi:SDCBP2(display_short)|uniprotkb:SITAC18(gene name synonym)|uniprotkb:Syndecan-binding protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549385|imex:IM-13585-34 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:NP_001186713.1|refseq:NP_056500.2|refseq:NP_536737.3|ensembl:ENSP00000342935|ensembl:ENSP00000354013|ensembl:ENST00000381808|ensembl:ENSP00000371229|ensembl:ENSP00000371233|ensembl:ENSG00000125775(gene)|ensembl:ENST00000360779(transcript)|ensembl:ENST00000381812(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046907"(intracellular transport)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR041489|ensembl:ENST00000339987(transcript) go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:vlEtVZkwLTte5PJ4i8ce+SwE/4Y9606 intact-crc:530A7AFD20B878D5|rigid:4fg0y9HH9SypjQgIOVrKc9jiebc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q9UJ41 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-913954|uniprotkb:B4DZM7|uniprotkb:Q3HKR2|uniprotkb:Q3HKR3|uniprotkb:Q53FG0|ensembl:ENSP00000284957|ensembl:ENSP00000415815 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:rabx5_human(display_long)|uniprotkb:Rabex-5(gene name synonym)|uniprotkb:Rabaptin-5-associated exchange factor for Rab5(gene name synonym)|uniprotkb:RAP1(gene name synonym)|uniprotkb:RABGEF1(gene name)|psi-mi:RABGEF1(display_short)|uniprotkb:RABEX5(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549390|imex:IM-13585-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 ensembl:ENSG00000154710(gene)|ensembl:ENST00000284957(transcript)|ensembl:ENST00000450873(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0055037"(recycling endosome)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR037191|interpro:IPR041545|rcsb pdb:1TXU|rcsb pdb:2C7M|rcsb pdb:2C7N|rcsb pdb:2OT3|rcsb pdb:4N3X|rcsb pdb:4N3Y|rcsb pdb:4N3Z|rcsb pdb:4Q9U|reactome:R-HSA-8854214|reactome:R-HSA-8876198|refseq:NP_055319.1|refseq:NP_001273989.1|refseq:NP_001273990.1|refseq:NP_001273991.1|dip:DIP-29348N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2019/05/28 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:+MNigZ2IH2ogPAFA5YTYT0rGWYg9606 intact-crc:3AD5FCAD2273B644|rigid:pXEKvZpTwIy+wMNNrfHOtguLh/M false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q9UJC3 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-746704|uniprotkb:O60561|uniprotkb:Q5TG44|uniprotkb:A8MU44|uniprotkb:B4DX15|uniprotkb:A8K8E9|intact:EBI-10969618|ensembl:ENSP00000360252 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:hook1_human(display_long)|uniprotkb:HOOK1(gene name)|psi-mi:HOOK1(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549395|imex:IM-13585-40 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:NP_056972.1|ensembl:ENSG00000134709(gene)|ensembl:ENST00000371208(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007030"(Golgi organization)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905198"(manchette assembly)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|mint:Q9UJC3 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:QOcYbuKfnNIlNKzos5v+0+A2h3I9606 intact-crc:B6D1168A26999140|rigid:qY1LjxP/+bBTEpIPSM0aOiERy0A false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q1K9E3 uniprotkb:Q8N9N5 intact:EBI-2549040 intact:EBI-744695|uniprotkb:B4DNJ9|uniprotkb:Q96GJ7|uniprotkb:Q9NWY1|uniprotkb:A8MX25|uniprotkb:A8MU25|ensembl:ENSP00000286122|ensembl:ENSP00000376902|uniprotkb:B2RCF7|uniprotkb:F5GZM0 psi-mi:rdrp_i72a2(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:banp_human(display_long)|uniprotkb:Btg3-associated nuclear protein(gene name synonym)|uniprotkb:Scaffold/matrix-associated region-1-binding protein(gene name synonym)|uniprotkb:BANP(gene name)|psi-mi:BANP(display_short)|uniprotkb:SMAR1(gene name synonym)|uniprotkb:BEND1(gene name synonym)|uniprotkb:BEN domain-containing protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549400|imex:IM-13585-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000166"(nucleotide binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003723"(RNA binding)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype) refseq:NP_001167010.1|refseq:NP_001167011.1|refseq:NP_001167014.1|refseq:NP_060339.2|refseq:NP_524576.2|ensembl:ENSG00000172530(gene)|ensembl:ENST00000286122(transcript)|ensembl:ENST00000393207(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR018379|interpro:IPR042343|mint:Q8N9N5|reactome:R-HSA-6804759|refseq:NP_001167012.1|refseq:NP_001167013.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:RGH5m1+2R60n47+FB8F9m1Lhngw381517 rogid:qTMuHfQDIsXAwdjSHa9hnPnKeYE9606 intact-crc:DC5D74580D4E95EF|rigid:vpxqABzt2GcHF4ClUCn8PEkS5Rw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q9P1Z2 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-749920|uniprotkb:B3KVA8|uniprotkb:Q6FI59|uniprotkb:Q71RC3|uniprotkb:Q86WF8|uniprotkb:Q96JU3|uniprotkb:Q9H090|intact:EBI-2558801|ensembl:ENSP00000449960 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:caco1_human(display_long)|uniprotkb:CALCOCO1(gene name)|psi-mi:CALCOCO1(display_short)|uniprotkb:KIAA1536(gene name synonym)|uniprotkb:Calphoglin(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-3(gene name synonym)|uniprotkb:Coiled-coil coactivator protein(gene name synonym)|uniprotkb:PP13275(orf name)|uniprotkb:UNQ2436/PRO4996(orf name) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549406|imex:IM-13585-62 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:NP_001137154.1|refseq:NP_065949.1|refseq:XP_016875196.1|dip:DIP-47322N|ensembl:ENSG00000012822(gene)|ensembl:ENST00000550804(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0070016"(armadillo repeat domain binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q9P1Z2 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:4M9Qyq+7GZ1w2UAN6k0ntGQNTvw9606 intact-crc:DE14604A1C56D9F2|rigid:uaYBywmdfidnIXd7JIwJR7EDyAY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9HA38 uniprotkb:P03495 intact:EBI-2548480|ensembl:ENSP00000311221|uniprotkb:Q96A21|uniprotkb:B3KVA6|uniprotkb:D3DNR1 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:zmat3_human(display_long)|uniprotkb:ZMAT3(gene name)|psi-mi:ZMAT3(display_short)|uniprotkb:PAG608(gene name synonym)|uniprotkb:WIG1(gene name synonym)|uniprotkb:Zinc finger protein WIG-1(gene name synonym)|uniprotkb:p53-activated gene 608 protein(gene name synonym) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549411|imex:IM-13585-46 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011511375.1|ensembl:ENSG00000172667(gene)|ensembl:ENST00000311417(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0040008"(regulation of growth)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR036236|mint:Q9HA38|refseq:NP_071915.1|refseq:NP_689426.1|refseq:XP_005247763.1 go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:mnbpErYi8VtTJUbKZPLM9eLmOHY9606 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 intact-crc:6EE4545C034B042B|rigid:JPGssaRXdZ4DNG9b3tfQmADhTn0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06827 uniprotkb:Q96IK5 intact:EBI-2549069|uniprotkb:Q1K9E0 intact:EBI-2548508|ensembl:ENSP00000282570|uniprotkb:Q9H826|uniprotkb:Q9H8V7|uniprotkb:Q9H927 psi-mi:ncap_i72a2(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:gmcl1_human(display_long)|uniprotkb:GMCL1(gene name)|psi-mi:GMCL1(display_short)|uniprotkb:GCL(gene name synonym)|uniprotkb:BTBD13(gene name synonym)|uniprotkb:SPATA29(gene name synonym)|uniprotkb:Spermatogenesis-associated protein 29(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549418|imex:IM-13585-58 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)") ensembl:ENSG00000087338(gene)|ensembl:ENST00000282570(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016363"(nuclear matrix)|go:"GO:0042802"(identical protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR043380|refseq:NP_848526.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:M0A/sVYptP1pDs1fchqvmPrTyCI381517 rogid:ED8yqySVu7BWxpw3DUSNBZSQWrk9606 intact-crc:DE288C0381012F03|rigid:15UFp9l5S8UP03Oph9usADNmlCo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:Q6NT76 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-2549423|ensembl:ENSP00000287701|ensembl:ENSP00000380516|uniprotkb:A8K3R8|uniprotkb:Q3Y6P1|uniprotkb:Q96GS5|uniprotkb:Q9H701|uniprotkb:A4K385|uniprotkb:B4DHY5|uniprotkb:D3DSU0 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:hmbx1_human(display_long)|uniprotkb:HMBOX1(gene name)|psi-mi:HMBOX1(display_short)|uniprotkb:HOT1(gene name synonym)|uniprotkb:Homeobox telomere-binding protein 1(gene name synonym)|uniprotkb:TAH1(gene name synonym)|uniprotkb:Telomere-associated homeobox-containing protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549462|imex:IM-13585-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N ensembl:ENSG00000147421(gene)|ensembl:ENST00000287701(transcript)|ensembl:ENST00000397358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051972"(regulation of telomerase activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006899(Hepatocyte nuclear factor 1, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR040363|mint:Q6NT76|rcsb pdb:2CUF|rcsb pdb:4J19|interpro:IPR001387(Helix-turn-helix type 3)|refseq:NP_001129198.1|refseq:NP_078843.2|refseq:NP_001311312.1|refseq:NP_001311313.1|refseq:NP_001311314.1|refseq:NP_001311315.1|refseq:NP_001311316.1|refseq:NP_001311317.1|refseq:NP_001311318.1|refseq:NP_001311319.1|refseq:NP_001311320.1|refseq:NP_001311321.1|refseq:NP_001311322.1|refseq:NP_001311323.1|refseq:NP_001311324.1|refseq:NP_001311311.1|refseq:NP_001317427.1|refseq:XP_016869314.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:Vap52i4o7ETkoZDzQ7zQqCHXVCA9606 intact-crc:FBED90F2746C2481|rigid:d/+FkFujXMl62NphckXvZdGoMYE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H898 uniprotkb:P03495 intact:EBI-2548542|ensembl:ENSP00000297737|uniprotkb:Q8WUT8 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:zmat4_human(display_long)|uniprotkb:ZMAT4(gene name)|psi-mi:ZMAT4(display_short) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549481|imex:IM-13585-51 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000297737(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR003604(Zinc finger, U1-type)|ensembl:ENSG00000165061(gene)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR036236|refseq:NP_001129203.1|refseq:NP_078921.1 go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:7zQ5iec+6Ax3lNsVDSq6pSu71W09606 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 intact-crc:D6309DF3D31B3262|rigid:LyXw9TcmdEfO8pHZ5kmBJxs0tOo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N5R6 uniprotkb:P03495 intact:EBI-740841|intact:EBI-953781|uniprotkb:B3KQ49|uniprotkb:A8K3U4|uniprotkb:A8MPQ6|uniprotkb:A8MV61|uniprotkb:A8MVU9|uniprotkb:Q9H5Q6|uniprotkb:Q8TAX6|intact:EBI-2320546|intact:EBI-11522976 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:ccd33_human(display_long)|uniprotkb:CCDC33(gene name)|psi-mi:CCDC33(display_short)|uniprotkb:Cancer/testis antigen 61(gene name synonym) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549486|imex:IM-13585-53 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079331.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0005777"(peroxisome)|refseq:NP_001274110.1|refseq:NP_877592.2|mint:Q8N5R6|interpro:IPR035892|interpro:IPR039889 go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:eEIn7pQyfdHWx8TeLJpYy0i/gww9606 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 intact-crc:9670BB26B587ACEA|rigid:gaiYcU0JS3fVLIH+VdtXHQuef2Y false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q8NHQ1 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-739624|ensembl:ENSP00000264982|ensembl:ENSP00000419231|uniprotkb:Q96B31|uniprotkb:Q9H2C3|uniprotkb:Q9H2Z1|uniprotkb:Q9H940|uniprotkb:D3DNE9|uniprotkb:B7Z5I8|uniprotkb:B7Z7E8|uniprotkb:F5GZX8 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:cep70_human(display_long)|uniprotkb:CEP70(gene name)|psi-mi:CEP70(display_short)|uniprotkb:BITE(gene name synonym)|uniprotkb:p10-binding protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549491|imex:IM-13585-80 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 ensembl:ENSG00000114107(gene)|ensembl:ENST00000264982(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|interpro:IPR019734|interpro:IPR037692|mint:Q8NHQ1|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|ensembl:ENST00000484888(transcript)|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_077817.2|refseq:XP_016862764.1|refseq:NP_001275893.1|refseq:NP_001275894.1|refseq:NP_001275895.1|refseq:NP_001275896.1|refseq:NP_001307527.1|refseq:NP_001307529.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:S4yveQWcvdVtAUX65gqrJ5Dv0Mc9606 intact-crc:28D71E55BCD58329|rigid:+LZf/IcxRdfoHy0vnKVl3OPbk0M false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:Q8NF50 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-2548605|uniprotkb:B7ZLP0|uniprotkb:E9PH09|ensembl:ENSP00000394888|uniprotkb:A2A350|uniprotkb:A2BDF2|uniprotkb:A4FU78|uniprotkb:Q3MV16|uniprotkb:Q5JPJ1|uniprotkb:Q8TEP1|uniprotkb:Q8WUY2|uniprotkb:Q9BYJ5|uniprotkb:Q9H1Q2|uniprotkb:Q9H1Q3|uniprotkb:Q9H308|uniprotkb:Q9H7P2|intact:EBI-11070681 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:dock8_human(display_long)|uniprotkb:DOCK8(gene name)|psi-mi:DOCK8(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549498|imex:IM-13585-54 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:XP_011516347.1|refseq:XP_011516349.1|ensembl:ENSG00000107099(gene)|ensembl:ENST00000432829(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061485"(memory T cell proliferation)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-983231|refseq:XP_011516350.1|refseq:NP_001177387.1|refseq:NP_001180465.1|refseq:NP_982272.2|refseq:XP_016870662.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:4ENO+3IOKfCUicfg8fxFQbwf4fg9606 intact-crc:3EA96F455F9F03CC|rigid:u/jv1MFRJpsmNo9JLEuwuhccr58 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q8NF50 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-2548605|uniprotkb:B7ZLP0|uniprotkb:E9PH09|ensembl:ENSP00000394888|uniprotkb:A2A350|uniprotkb:A2BDF2|uniprotkb:A4FU78|uniprotkb:Q3MV16|uniprotkb:Q5JPJ1|uniprotkb:Q8TEP1|uniprotkb:Q8WUY2|uniprotkb:Q9BYJ5|uniprotkb:Q9H1Q2|uniprotkb:Q9H1Q3|uniprotkb:Q9H308|uniprotkb:Q9H7P2|intact:EBI-11070681 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:dock8_human(display_long)|uniprotkb:DOCK8(gene name)|psi-mi:DOCK8(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549503|imex:IM-13585-56 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:XP_011516347.1|refseq:XP_011516349.1|ensembl:ENSG00000107099(gene)|ensembl:ENST00000432829(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061485"(memory T cell proliferation)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-983231|refseq:XP_011516350.1|refseq:NP_001177387.1|refseq:NP_001180465.1|refseq:NP_982272.2|refseq:XP_016870662.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:4ENO+3IOKfCUicfg8fxFQbwf4fg9606 intact-crc:C8185489001BEABB|rigid:0J1Wb6TZwk7kcz49hetlVLFR4is false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N6Y0 uniprotkb:P06827 intact:EBI-739895|uniprotkb:Q8NBX7|uniprotkb:Q96KH3|uniprotkb:Q9BYI8|uniprotkb:A8K7L6|uniprotkb:B2RCR9|ensembl:ENSP00000252597 intact:EBI-2549069|uniprotkb:Q1K9E0 psi-mi:usbp1_human(display_long)|uniprotkb:USHBP1(gene name)|psi-mi:USHBP1(display_short)|uniprotkb:MCC-2(gene name synonym)|uniprotkb:AIE-75-binding protein(gene name synonym)|uniprotkb:AIEBP(gene name synonym)|uniprotkb:MCC2(gene name synonym)|uniprotkb:Mutated in colon cancer protein 2(gene name synonym) psi-mi:ncap_i72a2(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549508|imex:IM-13585-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001284632.1|refseq:NP_114147.2|refseq:NP_001308346.1|ensembl:ENSG00000130307(gene)|ensembl:ENST00000252597(transcript)|go:"GO:0030165"(PDZ domain binding)|interpro:IPR019536|interpro:IPR040171 go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)") go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:vY1qx73Ju/z7WDu6k1kd10ZDVRo9606 rogid:M0A/sVYptP1pDs1fchqvmPrTyCI381517 intact-crc:154FA1A11D9E289F|rigid:1kXuDV+DfsR0RB+ZcDqApZsqvQI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q8N6Y0 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-739895|uniprotkb:Q8NBX7|uniprotkb:Q96KH3|uniprotkb:Q9BYI8|uniprotkb:A8K7L6|uniprotkb:B2RCR9|ensembl:ENSP00000252597 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:usbp1_human(display_long)|uniprotkb:USHBP1(gene name)|psi-mi:USHBP1(display_short)|uniprotkb:MCC-2(gene name synonym)|uniprotkb:AIE-75-binding protein(gene name synonym)|uniprotkb:AIEBP(gene name synonym)|uniprotkb:MCC2(gene name synonym)|uniprotkb:Mutated in colon cancer protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549513|imex:IM-13585-59 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:NP_001284632.1|refseq:NP_114147.2|refseq:NP_001308346.1|ensembl:ENSG00000130307(gene)|ensembl:ENST00000252597(transcript)|go:"GO:0030165"(PDZ domain binding)|interpro:IPR019536|interpro:IPR040171 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:vY1qx73Ju/z7WDu6k1kd10ZDVRo9606 intact-crc:99D63870A9006465|rigid:GIzAzOmRdGNO9nWT60JuxkJD/BI false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:Q9BRK4 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-741037|ensembl:ENSP00000359240|ensembl:ENSP00000359243|uniprotkb:Q8N3I0|uniprotkb:Q96J79|uniprotkb:Q96JL2|uniprotkb:B1AL14|uniprotkb:D3DR72 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:lzts2_human(display_long)|uniprotkb:Protein LAPSER1(gene name synonym)|uniprotkb:LZTS2(gene name)|psi-mi:LZTS2(display_short)|uniprotkb:KIAA1813(gene name synonym)|uniprotkb:LAPSER1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549518|imex:IM-13585-57 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:NP_115805.1|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597|mint:Q9BRK4|ensembl:ENSG00000107816(gene)|ensembl:ENST00000370220(transcript)|ensembl:ENST00000370223(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|refseq:XP_016872269.1|refseq:NP_001305028.1|refseq:NP_001305029.1|refseq:NP_001305030.1|refseq:XP_005270279.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:OaMJmnmfm6JniKUJeyg7fS6zRcw9606 intact-crc:E5B3DA95CDC1AB83|rigid:PP3iXdvuw2Qkhf71KIkJBHwdEQU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6P1W5 uniprotkb:Q67296 intact:EBI-946029|uniprotkb:B3KVT1|uniprotkb:Q96IC8|ensembl:ENSP00000435634|uniprotkb:D3DPR3|uniprotkb:E9PJ76 intact:EBI-2548937|uniprotkb:Q1K9E4 psi-mi:ca094_human(display_long)|uniprotkb:C1orf94(gene name)|psi-mi:C1orf94(display_short) psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549523|imex:IM-13585-63 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001128206.1|refseq:NP_116273.2|ensembl:ENSG00000142698(gene)|ensembl:ENST00000488417(transcript)|interpro:IPR031496 interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:y1o4xWvTl2CBA1J7jsP7y8ZjLzM9606 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 intact-crc:A6AADA510A59C4B1|rigid:NMM7ZKgBUj58jDCYlobr3d3PMDk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96MC5 uniprotkb:P06827 intact:EBI-718468|uniprotkb:O00223|uniprotkb:O75769|uniprotkb:Q8IZ36|uniprotkb:Q96H25|ensembl:ENSP00000300006|ensembl:ENSP00000483858 intact:EBI-2549069|uniprotkb:Q1K9E0 psi-mi:merb1_human(display_long)|uniprotkb:BMERB1(gene name)|psi-mi:BMERB1(display_short)|uniprotkb:C16orf45(gene name synonym) psi-mi:ncap_i72a2(display_long)|uniprotkb:NP(gene name)|psi-mi:NP(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549528|imex:IM-13585-64 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135941.1|refseq:NP_149978.1|ensembl:ENSG00000166780(gene)|ensembl:ENSG00000278823(gene)|ensembl:ENST00000300006(transcript)|ensembl:ENST00000615273(transcript)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0021822"(negative regulation of cell motility involved in cerebral cortex radial glia guided migration)|interpro:IPR022735|interpro:IPR040127 go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR002141("Influenza virus nucleoprotein (NP)") go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:DSzrN8rIE3sJnAJeI9Bg9GuhClg9606 rogid:M0A/sVYptP1pDs1fchqvmPrTyCI381517 intact-crc:871CEE6B125074A3|rigid:6VpfOVpXTUxvXW7PpBcg1g56J3M false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y2D8 uniprotkb:P03495 intact:EBI-2212028|uniprotkb:B4DFE3|uniprotkb:J3KR02|uniprotkb:A8K8W0|uniprotkb:D3DT13|uniprotkb:Q6P2P8|uniprotkb:Q6ULS1|uniprotkb:Q7L168|uniprotkb:Q9UIX0|intact:EBI-10964529|ensembl:ENSP00000340279 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:adip_human(display_long)|uniprotkb:SSX2IP(gene name)|psi-mi:SSX2IP(display_short)|uniprotkb:KIAA0923(gene name synonym)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549533|imex:IM-13585-61 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011538912.1|refseq:NP_001159765.1|refseq:NP_001159766.1|refseq:NP_001159767.1|refseq:NP_001159889.1|refseq:NP_054740.3|refseq:XP_005270484.1|refseq:XP_005270485.1|refseq:XP_006710394.1|refseq:XP_016855723.1|ensembl:ENSG00000117155(gene)|ensembl:ENST00000342203(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|mint:Q9Y2D8 go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:E0VeMRF9SrpQKSJFP01XEbMjeF89606 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 intact-crc:DDD2643FFB9F76C2|rigid:BVnUPmcqsbf59bUwiYiYO2aRRQ0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96FJ2 uniprotkb:P69258 intact:EBI-742371|uniprotkb:B2R5B4|ensembl:ENSP00000477310 intact:EBI-2549210|uniprotkb:P03503|uniprotkb:P03507|uniprotkb:Q1K9D6 psi-mi:dyl2_human(display_long)|uniprotkb:DYNLL2(gene name)|psi-mi:DYNLL2(display_short)|uniprotkb:Dynein light chain LC8-type 2(gene name synonym)|uniprotkb:DLC2(gene name synonym)|uniprotkb:8 kDa dynein light chain b(gene name synonym) psi-mi:nep_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:Non-structural protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549538|imex:IM-13585-66 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005813"(centrosome)|refseq:NP_542408.1|ensembl:ENSG00000264364(gene)|ensembl:ENST00000579991(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007017"(microtubule-based process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030286"(dynein complex)|go:"GO:0031475"(myosin V complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097542"(ciliary tip)|go:"GO:0097731"(9+0 non-motile cilium)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:Q96FJ2|rcsb pdb:2XQQ|rcsb pdb:3P8M|rcsb pdb:4D07|reactome:R-HSA-139910|reactome:R-HSA-141444|reactome:R-HSA-1632852|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5620924|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025 go:"GO:0039675"(exit of virus from host cell nucleus through nuclear pore)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000968("Influenza non-structural protein (NS2)") go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:4RFpJF40RBja5mOvt/aCv3miiDU9606 rogid:GICBftr026aD4L9bQaG7RvXAv7s381517 intact-crc:D55F070A6752107B|rigid:1O1U4Pw2ELUlvkrzXaE46XoCkrg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:Q8TD10 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-2548751|ensembl:ENSP00000333539|ensembl:ENSP00000379589|ensembl:ENSP00000444254|ensembl:ENSP00000506738|uniprotkb:Q7Z3J0|uniprotkb:Q8IV14|uniprotkb:D3DSA4 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:mipo1_human(display_long)|uniprotkb:MIPOL1(gene name)|psi-mi:MIPOL1(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549544|imex:IM-13585-70 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 ensembl:ENSG00000151338(gene)|ensembl:ENST00000327441(transcript)|ensembl:ENST00000396294(transcript)|ensembl:ENST00000537471(transcript)|ensembl:ENST00000684589(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR026175|mint:Q8TD10|refseq:NP_001182225.1|refseq:NP_001182226.1|refseq:NP_620059.1|refseq:XP_016876492.1|refseq:XP_016876493.1|refseq:XP_016876494.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:X4gY7nzDtnrS2yil7QhmLH968Ug9606 intact-crc:ACE3280A2C221EE0|rigid:RAR/KvNXTZnut/OfJjOmJ6k3B7E false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0DOF4 uniprotkb:Q8N448 intact:EBI-2548962|uniprotkb:P03486|uniprotkb:P10919|uniprotkb:Q1K9D7|uniprotkb:P63233 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 psi-mi:m1_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549549|imex:IM-13585-78 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR036039|interpro:IPR037533 refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:HeH3SZ6mulGeBKY5+Px7jYOSgk8381517 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 intact-crc:6302A8CD0A3D4B7E|rigid:pxf4C598zjL3jyEO1HIcQqIWY+4 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0DOF5 uniprotkb:Q8N448 intact:EBI-2548903|uniprotkb:P03490|uniprotkb:Q1K9D8|uniprotkb:P63231 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 psi-mi:m2_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short)|uniprotkb:Proton channel protein M2(gene name synonym) psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549554|imex:IM-13585-73 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:1MP6|rcsb pdb:2KIH|rcsb pdb:2KWX|rcsb pdb:2L0J|rcsb pdb:2RLF|go:"GO:0005216"(ion channel activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042802"(identical protein binding)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|rcsb pdb:2N70|rcsb pdb:4QK7|rcsb pdb:4QKC|rcsb pdb:4QKL|rcsb pdb:4QKM|rcsb pdb:5C02|interpro:IPR002089(Influenza virus matrix protein 2) refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:hxwAh+YjNu/gDNuRDdOIiYyW5pQ381517 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 intact-crc:AACF34818DA067F9|rigid:x8z9E4MGbNLFvy7SwVL0cYfx2uY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03495 uniprotkb:Q8N448 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549559|imex:IM-13585-71 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 intact-crc:D525CB063280FB1A|rigid:zxhbYPmqGmrnki3r2HDFAzx2txY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N448 uniprotkb:Q1K9E2 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 intact:EBI-2549564 psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:pa_i72a2(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549573|imex:IM-13585-74 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0075526"(cap snatching)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR038372|interpro:IPR037534 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 rogid:5ZoZDk03BTspp6W2Ur+/rL5jHN0381517 intact-crc:1279EF246A2AA677|rigid:yeQTKCRsQXMwaCGdHXoMAyt2bbo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N448 uniprotkb:Q67296 intact:EBI-2340947|uniprotkb:Q6ZMH2|uniprotkb:Q5W0P0|uniprotkb:Q96SH4|ensembl:ENSP00000325929|ensembl:ENSP00000497224 intact:EBI-2548937|uniprotkb:Q1K9E4 psi-mi:lnx2_human(display_long)|uniprotkb:LNX2(gene name)|psi-mi:LNX2(display_short)|uniprotkb:PDZRN1(gene name synonym)|uniprotkb:Numb-binding protein 2(gene name synonym)|uniprotkb:PDZ domain-containing RING finger protein 1(gene name synonym) psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549578|imex:IM-13585-75 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699202.1|refseq:XP_016875923.1|ensembl:ENSG00000139517(gene)|ensembl:ENST00000316334(transcript)|ensembl:ENST00000649248(transcript)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036034|mint:Q8N448|rcsb pdb:2VWR|rcsb pdb:5DIN|rcsb pdb:5E11|rcsb pdb:5E1Y|rcsb pdb:5E21|rcsb pdb:5E22 interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:cIS5t4XkbnIgelDlUc692nI285g9606 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 intact-crc:2394F0CA6D04126D|rigid:AJBw9ONZC5rKUqJR+r2xT/NQ1k8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N5I3 uniprotkb:Q67296 intact:EBI-745755|uniprotkb:Q0P6D0|uniprotkb:Q8IU75|uniprotkb:Q8N3Q9|uniprotkb:A2A2X9|ensembl:ENSP00000324191 intact:EBI-2548937|uniprotkb:Q1K9E4 psi-mi:kcnrg_human(display_long)|uniprotkb:Protein CLLD4(gene name synonym)|uniprotkb:KCNRG(gene name)|psi-mi:KCNRG(display_short)|uniprotkb:CLLD4(gene name synonym) psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549583|imex:IM-13585-76 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775876.1|refseq:NP_955751.1|go:"GO:0051260"(protein homooligomerization)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|ensembl:ENSG00000198553(gene)|ensembl:ENST00000312942(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0042802"(identical protein binding) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Zl81okdqtLzwJC8HsHA+g9n7JXs9606 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 intact-crc:14F1D3F625AFA6AD|rigid:EF5NZbOdehzmZF1w7ZLdA+OuWnk false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) intact:EBI-2548851 uniprotkb:P0DOF4 - intact:EBI-2548962|uniprotkb:P03486|uniprotkb:P10919|uniprotkb:Q1K9D7|uniprotkb:P63233 psi-mi:c4am89_human(display_short)|psi-mi:EBI-2548851(display_long)|uniprotkb:NBPF22P(gene name)|psi-mi:NBPF22P(display_short) psi-mi:m1_i72a2(display_long)|uniprotkb:M(gene name)|psi-mi:M(display_short) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549588|imex:IM-13585-72 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:C4AM89(uniprot-removed-ac) go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR015423(Influenza matrix M1, N-terminal subdomain 1)|interpro:IPR001561(Influenza matrix M1, N-terminal)|interpro:IPR013188(Influenza matrix M1, C-terminal)|interpro:IPR015799(Influenza matrix M1, N-terminal subdomain 2)|interpro:IPR036039|interpro:IPR037533 go:"GO:0019048"(modulation by virus of host process) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:BzqVlUbqCzLHJTtyvjXTxaOm7Dc9606 rogid:HeH3SZ6mulGeBKY5+Px7jYOSgk8381517 intact-crc:D7FFDFACA6CB01A3|rigid:umwN8vs1BCeUQ75rxrxgcTituxU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q67296 uniprotkb:P0C7W6 intact:EBI-2548937|uniprotkb:Q1K9E4 intact:EBI-2548868|ensembl:ENSP00000329860 psi-mi:pb2_i72a2(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym) psi-mi:cc172_human(display_long)|uniprotkb:CCDC172(gene name)|psi-mi:CCDC172(display_short)|uniprotkb:C10orf96(gene name synonym) psi-mi:"MI:0018"(two hybrid) Shapira et al. (2009) imex:IM-13585|pubmed:20064372 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2549593|imex:IM-13585-79 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|rcsb pdb:5WL0|interpro:IPR037258 refseq:NP_940917.1|ensembl:ENSG00000182645(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0097225"(sperm midpiece)|interpro:IPR029618|mint:P0C7W6|ensembl:ENST00000333254(transcript)|refseq:XP_016871695.1 go:"GO:0019048"(modulation by virus of host process) - - figure legend:Supp. Tables 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/01/26 2014/10/16 rogid:Pice+xwpgOEVkDf7F6hukqFIoVY381517 rogid:JAaMYXob1bjFtiCvHmuzgCvq+FU9606 intact-crc:EFAD5816D44AC709|rigid:l6J+2lP9KNHEAXGrzIjJL4jAI08 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)