#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
ensembl:ENSMUSG00000000567	uniprotkb:O88470	intact:EBI-2526131	intact:EBI-2526133|uniprotkb:Q8K3X9|ensembl:ENSMUSP00000053297	psi-mi:sox9_mouse_gene(display_short)|psi-mi:ENSMUSG00000000567(display_long)	psi-mi:foxl2_mouse(display_long)|uniprotkb:Foxl2(gene name)|psi-mi:Foxl2(display_short)|uniprotkb:Pfrk(gene name synonym)|uniprotkb:Pituitary forkhead factor(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Uhlenhaut et al. (2009)	imex:IM-12116|pubmed:20005806	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2526162|imex:IM-12116-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000050397(gene)|ensembl:ENSMUST00000051312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002074"(extraocular skeletal muscle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007338"(single fertilization)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019101"(female somatic sex determination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0043028"(cysteine-type endopeptidase regulator activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0060014"(granulosa cell differentiation)|go:"GO:0060065"(uterus development)|go:"GO:0090543"(Flemming body)|interpro:IPR001766(Fork head transcription factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-3232118|refseq:NP_036150.1	-	-	-	figure legend:Fig. 5C|comment:FOXL2 binds to the cis-regulatory element for testis-specific Sox9 expression, referred to as TESCO.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ovary)|taxid:10090(Mouse ovary)	-	2010/01/04	2014/10/16	-	rogid:EIC3xkaAdiLxfAV8qHxjNtCpP7c10090	intact-crc:8228018BFBEC15E6	false	-	ha tag:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P19785	ensembl:ENSMUSG00000000567	intact:EBI-346765|uniprotkb:Q9JJT5|uniprotkb:Q9QY51|uniprotkb:Q9QY52|ensembl:ENSMUSP00000070070|ensembl:ENSMUSP00000101214|ensembl:ENSMUSP00000101215	intact:EBI-2526131	psi-mi:esr1_mouse(display_long)|uniprotkb:Esr1(gene name)|psi-mi:Esr1(display_short)|uniprotkb:Esr(gene name synonym)|uniprotkb:Estr(gene name synonym)|uniprotkb:Estra(gene name synonym)|uniprotkb:Nr3a1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:sox9_mouse_gene(display_short)|psi-mi:ENSMUSG00000000567(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Uhlenhaut et al. (2009)	imex:IM-12116|pubmed:20005806	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2526194|imex:IM-12116-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:XP_011241368.1|refseq:XP_011241369.1|refseq:XP_011241370.1|refseq:NP_031982.1|refseq:NP_001289460.1|refseq:NP_001289461.1|refseq:XP_006512496.1|refseq:XP_006512497.1|refseq:XP_006512498.1|reactome:R-MMU-383280|reactome:R-MMU-4090294|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-8866910|reactome:R-MMU-8931987|reactome:R-MMU-8939211|reactome:R-MMU-9009391|reactome:R-MMU-9018519|reactome:R-MMU-1257604|go:"GO:0035327"|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042562"(hormone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P19785|reactome:R-MMU-1251985|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|ensembl:ENSMUSG00000019768(gene)|ensembl:ENSMUST00000067086(transcript)|ensembl:ENSMUST00000105589(transcript)|ensembl:ENSMUST00000105590(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)	-	-	-	-	figure legend:Fig. 6A|comment:ESR1 binds to the cis-regulatory element for testis-specific Sox9 expression, referred to as TESCO.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ovary)|taxid:10090(Mouse ovary)	-	2010/01/04	2014/10/16	rogid:rGimZuxFcndkD0fWkLb/pZLxcZc10090	-	intact-crc:673262B44C90194A	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:O88470	uniprotkb:P19785	intact:EBI-2526133|uniprotkb:Q8K3X9|ensembl:ENSMUSP00000053297	intact:EBI-346765|uniprotkb:Q9JJT5|uniprotkb:Q9QY51|uniprotkb:Q9QY52|ensembl:ENSMUSP00000070070|ensembl:ENSMUSP00000101214|ensembl:ENSMUSP00000101215	psi-mi:foxl2_mouse(display_long)|uniprotkb:Foxl2(gene name)|psi-mi:Foxl2(display_short)|uniprotkb:Pfrk(gene name synonym)|uniprotkb:Pituitary forkhead factor(gene name synonym)	psi-mi:esr1_mouse(display_long)|uniprotkb:Esr1(gene name)|psi-mi:Esr1(display_short)|uniprotkb:Esr(gene name synonym)|uniprotkb:Estr(gene name synonym)|uniprotkb:Estra(gene name synonym)|uniprotkb:Nr3a1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Uhlenhaut et al. (2009)	imex:IM-12116|pubmed:20005806	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2526203|imex:IM-12116-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000050397(gene)|ensembl:ENSMUST00000051312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002074"(extraocular skeletal muscle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007338"(single fertilization)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019101"(female somatic sex determination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0043028"(cysteine-type endopeptidase regulator activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0060014"(granulosa cell differentiation)|go:"GO:0060065"(uterus development)|go:"GO:0090543"(Flemming body)|interpro:IPR001766(Fork head transcription factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-3232118|refseq:NP_036150.1	refseq:XP_011241368.1|refseq:XP_011241369.1|refseq:XP_011241370.1|refseq:NP_031982.1|refseq:NP_001289460.1|refseq:NP_001289461.1|refseq:XP_006512496.1|refseq:XP_006512497.1|refseq:XP_006512498.1|reactome:R-MMU-383280|reactome:R-MMU-4090294|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-8866910|reactome:R-MMU-8931987|reactome:R-MMU-8939211|reactome:R-MMU-9009391|reactome:R-MMU-9018519|reactome:R-MMU-1257604|go:"GO:0035327"|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042562"(hormone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P19785|reactome:R-MMU-1251985|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|ensembl:ENSMUSG00000019768(gene)|ensembl:ENSMUST00000067086(transcript)|ensembl:ENSMUST00000105589(transcript)|ensembl:ENSMUST00000105590(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/01/04	2014/10/16	rogid:EIC3xkaAdiLxfAV8qHxjNtCpP7c10090	rogid:rGimZuxFcndkD0fWkLb/pZLxcZc10090	intact-crc:7E85E85E7C865999|rigid:+NNDW/rRQu2bHvPGig5rlON1+OY	false	flag tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O08537	uniprotkb:O88470	intact:EBI-2526214|uniprotkb:O35635|uniprotkb:O70519|ensembl:ENSMUSP00000106051|uniprotkb:B2RUC6|uniprotkb:E9QKX7|uniprotkb:Q8BG65|uniprotkb:Q91Z86	intact:EBI-2526133|uniprotkb:Q8K3X9|ensembl:ENSMUSP00000053297	psi-mi:esr2_mouse(display_long)|uniprotkb:Esr2(gene name)|psi-mi:Esr2(display_short)|uniprotkb:Estrb(gene name synonym)|uniprotkb:Nr3a2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 2(gene name synonym)	psi-mi:foxl2_mouse(display_long)|uniprotkb:Foxl2(gene name)|psi-mi:Foxl2(display_short)|uniprotkb:Pfrk(gene name synonym)|uniprotkb:Pituitary forkhead factor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Uhlenhaut et al. (2009)	imex:IM-12116|pubmed:20005806	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2526272|imex:IM-12116-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021055(gene)|ensembl:ENSMUST00000110421(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001764"(neuron migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042562"(hormone binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048521"(negative regulation of behavior)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000252"(negative regulation of feeding behavior)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021064|interpro:IPR024178|interpro:IPR028355|interpro:IPR035500|reactome:R-MMU-1257604|reactome:R-MMU-383280|go:"GO:0008628"(hormone-mediated apoptotic signaling pathway)|reactome:R-MMU-6811558|reactome:R-MMU-8939211|reactome:R-MMU-9009391|refseq:NP_034287.3|refseq:NP_997590.1	ensembl:ENSMUSG00000050397(gene)|ensembl:ENSMUST00000051312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002074"(extraocular skeletal muscle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007338"(single fertilization)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0019101"(female somatic sex determination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0043028"(cysteine-type endopeptidase regulator activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0060014"(granulosa cell differentiation)|go:"GO:0060065"(uterus development)|go:"GO:0090543"(Flemming body)|interpro:IPR001766(Fork head transcription factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-3232118|refseq:NP_036150.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/01/04	2014/10/16	rogid:6nwtzkdAliApe1EECI1kzK98RtI10090	rogid:EIC3xkaAdiLxfAV8qHxjNtCpP7c10090	intact-crc:6AB26E0D42F09500|rigid:Y+61hTJgupe6Zoijn5v5CJjdAG8	false	v5 tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9QZ59	uniprotkb:Q04887	intact:EBI-2526321|uniprotkb:Q9QZ37|uniprotkb:Q9QZA4|ensembl:ENSMUSP00000025755|uniprotkb:Q19AV2|uniprotkb:Q2TDQ9|uniprotkb:Q6Y951|uniprotkb:Q6Y953	intact:EBI-2526286|uniprotkb:Q8C7L2|uniprotkb:Q91ZK2|uniprotkb:Q99KQ0|ensembl:ENSMUSP00000000579	psi-mi:dmrt1_mouse(display_long)|uniprotkb:Dmrt1(gene name)|psi-mi:Dmrt1(display_short)	psi-mi:sox9_mouse(display_long)|uniprotkb:Sox9(gene name)|psi-mi:Sox9(display_short)|uniprotkb:Sox-9(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Uhlenhaut et al. (2009)	imex:IM-12116|pubmed:20005806	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2526338|imex:IM-12116-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024837(gene)|ensembl:ENSMUST00000025755(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002176"(male germ cell proliferation)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046661"(male sex differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048599"(oocyte development)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:1900107"(regulation of nodal signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|interpro:IPR001275(DM DNA-binding)|interpro:IPR022114|interpro:IPR026607|interpro:IPR036407|go:"GO:0030238"(male sex determination)|refseq:NP_056641.2	go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030238"(male sex determination)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030850"(prostate gland development)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0030903"(notochord development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060174"(limb bud formation)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060512"(prostate gland morphogenesis)|go:"GO:0060517"(epithelial cell proliferation involved in prostatic bud elongation)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060784"(regulation of cell proliferation involved in tissue homeostasis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061046"(regulation of branching involved in lung morphogenesis)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070384"(Harderian gland development)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072034"(renal vesicle induction)|go:"GO:0072170"(metanephric tubule development)|go:"GO:0072189"(ureter development)|go:"GO:0072190"(ureter urothelium development)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097065"(anterior head development)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1904864"(negative regulation of beta-catenin-TCF complex assembly)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:2000794"(regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR029548|interpro:IPR036910|rcsb pdb:4S2Q|reactome:R-MMU-3769402|reactome:R-MMU-8878166|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|ensembl:ENSMUST00000000579(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002683"(negative regulation of immune system process)|go:"GO:0003170"(heart valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003188"(heart valve formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0003415"(chondrocyte hypertrophy)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|ensembl:ENSMUSG00000000567(gene)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|refseq:NP_035578.3	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ovary)|taxid:10090(Mouse ovary)	-	2010/01/04	2014/10/16	rogid:BuC0exNwAzA48tX6o1rFh8FQUtQ10090	rogid:IkQJxtiiNc+HDqw4ZwS97UCbbo810090	intact-crc:03A60364A8AAD037|rigid:3XjOkprv82nD8CJkoc2PGQsfSU8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)