#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P62258 uniprotkb:P08151 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 intact:EBI-308084|uniprotkb:Q8TDN9|ensembl:ENSP00000228682|uniprotkb:D0EUY3|uniprotkb:E9PQQ9|uniprotkb:F5H6H8 psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Asaoka et al. (2010) pubmed:19996099|mint:MINT-8009500|doi:10.1074/jbc.M109.038232 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7668449|mint:MINT-8009509 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-8009510(identity)|uniprotkb:P62258(original identifier) refseq:NP_001161081.1|ensembl:ENSG00000111087(gene)|ensembl:ENST00000228682(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009611"(response to wounding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030850"(prostate gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001153517.1|refseq:NP_005260.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0060032"(notochord regression)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000345"(regulation of hepatocyte proliferation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032850|interpro:IPR036236|interpro:IPR043359|rcsb pdb:2GLI|rcsb pdb:4BLB|rcsb pdb:4KMD|rcsb pdb:5OM0|reactome:R-HSA-5610780|reactome:R-HSA-5610787|reactome:R-HSA-5632684|reactome:R-HSA-5635851|refseq:XP_011536491.1|ensembl:ENSP00000228682|ensembl:ENST00000528467|ensembl:ENSP00000434408|ensembl:ENST00000543426|ensembl:ENSP00000437607|ensembl:ENST00000546141|ensembl:ENSP00000441006|dip:DIP-32536N|mint:MINT-8009513(identity)|uniprotkb:P08151(original identifier) - - - comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/21 2014/10/16 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606 intact-crc:44A712DFA990AD33|rigid:ElCJppRpneIn1ZvNzPfvLjfgnvI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62258 uniprotkb:P10071 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 intact:EBI-308055|uniprotkb:A4D1W1|uniprotkb:O75219|uniprotkb:Q17RW4|uniprotkb:Q75MT0|uniprotkb:Q75MU9|uniprotkb:Q9UDT5|uniprotkb:Q9UJ39|ensembl:ENSP00000379258|ensembl:ENSP00000502957|ensembl:ENSP00000503743 psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:gli3_human(display_long)|uniprotkb:GLI3(gene name)|psi-mi:GLI3(display_short)|uniprotkb:GLI3 full-length protein(gene name synonym)|uniprotkb:GLI3 form of 190 kDa(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Asaoka et al. (2010) pubmed:19996099|mint:MINT-8009500|doi:10.1074/jbc.M109.038232 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7668584|mint:MINT-8009523 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-8009524(identity)|uniprotkb:P62258(original identifier) refseq:NP_000159.3|ensembl:ENSG00000106571(gene)|ensembl:ENST00000395925(transcript)|ensembl:ENST00000677605(transcript)|ensembl:ENST00000678429(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021775"(smoothened signaling pathway involved in ventral spinal cord interneuron specification)|go:"GO:0021776"(smoothened signaling pathway involved in spinal cord motor neuron cell fate specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0022018"(lateral ganglionic eminence cell proliferation)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030850"(prostate gland development)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042060"(wound healing)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0060594"(mammary gland specification)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0060840"(artery development)|go:"GO:0060873"(anterior semicircular canal development)|go:"GO:0060875"(lateral semicircular canal development)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:0120223"(larynx morphogenesis)|go:"GO:1901620"(regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043585"(nose morphogenesis)|go:"GO:0043586"(tongue development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR032851|interpro:IPR036236|interpro:IPR043359|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|mint:P10071|rcsb pdb:4BLD|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5632684|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|reactome:R-HSA-5635851|reactome:R-HSA-8940973|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060366"(lambdoid suture morphogenesis)|go:"GO:0060367"(sagittal suture morphogenesis)|dip:DIP-32538N|mint:MINT-8009527(identity)|uniprotkb:P10071(original identifier) - - - comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/21 2014/10/16 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 rogid:BOHGgIuKgq0gUSahFeRaKnRmoMs9606 intact-crc:405DE402985B78E0|rigid:zedXcHbCoTz0T6EScU+rUg0gxaE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q0VGV1 uniprotkb:P62258 intact:EBI-7668520|intact:MINT-7997541 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:q0vgv1_mouse(display_long)|uniprotkb:Gli2(gene name)|psi-mi:Gli2(display_short) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Asaoka et al. (2010) pubmed:19996099|mint:MINT-8009500|doi:10.1074/jbc.M109.038232 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7668516|mint:MINT-8009516 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043359|mint:MINT-8009520(identity)|uniprotkb:Q0VGV1(original identifier) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-8009517(identity)|uniprotkb:P62258(original identifier) - comment:mint - comment:domino|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/21 2014/10/16 rogid:w3EUYyRoZROFIT0k2rRIZNnuexY10090 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 intact-crc:185F9D3191ED5F5F|rigid:G1FWSQIOEAgXdWucX4DQpyj2bU4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)