#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16104	uniprotkb:Q9NUW8	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-2902553|ensembl:ENSP00000337353|ensembl:ENSP00000377099|uniprotkb:Q2HXX4|uniprotkb:Q96BK7|uniprotkb:Q9NZM7|uniprotkb:Q9NZM8|uniprotkb:Q86TV8	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:tydp1_human(display_long)|uniprotkb:TDP1(gene name)|psi-mi:TDP1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Das et al. (2009)	pubmed:19851285|imex:IM-13895|mint:MINT-7542621|doi:10.1038/emboj.2009.302	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7537316|mint:MINT-7542699|imex:IM-13895-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|mint:MINT-7542702(identity)	ensembl:ENSG00000042088(gene)|ensembl:ENST00000335725(transcript)|ensembl:ENST00000393454(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0017005"(3'-tyrosyl-DNA phosphodiesterase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010347(Tyrosyl-DNA phosphodiesterase)|mint:Q9NUW8|rcsb pdb:1JY1|rcsb pdb:1MU7|rcsb pdb:1MU9|rcsb pdb:1NOP|rcsb pdb:1QZQ|rcsb pdb:1RFF|rcsb pdb:1RFI|rcsb pdb:1RG1|rcsb pdb:1RG2|rcsb pdb:1RGT|rcsb pdb:1RGU|rcsb pdb:1RH0|rcsb pdb:5NW9|rcsb pdb:5NWA|rcsb pdb:6DHU|rcsb pdb:6DIE|rcsb pdb:6DIH|rcsb pdb:6DIM|rcsb pdb:6DJD|rcsb pdb:6DJE|rcsb pdb:6DJF|rcsb pdb:6DJG|rcsb pdb:6DJH|rcsb pdb:6DJI|rcsb pdb:6DJJ|rcsb pdb:6MJ5|rcsb pdb:6MYZ|rcsb pdb:6MZ0|rcsb pdb:6N0D|rcsb pdb:6N0N|rcsb pdb:6N0O|rcsb pdb:6N0R|rcsb pdb:6N17|rcsb pdb:6N19|rcsb pdb:6W4R|rcsb pdb:6W7J|rcsb pdb:6W7K|rcsb pdb:6W7L|reactome:R-HSA-5693571|refseq:XP_011535244.1|refseq:XP_011535245.1|refseq:NP_001008744.1|refseq:NP_060789.2|refseq:XP_006720260.1|refseq:XP_006720261.1|refseq:XP_016876928.1|refseq:XP_016876931.1|refseq:XP_016876932.1|refseq:XP_016876933.1|refseq:XP_005267904.1|refseq:XP_005267905.1|mint:MINT-7542701(identity)	go:"GO:0005634"(nucleus)	-	-	comment:homomint|comment:mint|figure legend:f2b f2c f2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2010/01/12	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:7ain8+0TMD1xcADMpcQ0WKn4aIc9606	intact-crc:56B2275A44C239E6|rigid:aedFQQHxhPUmf2dME6ptMXSvSr0	false	-	phosphorylated residue:81-81(MINT-7542775)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q13315	uniprotkb:Q9NUW8	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	intact:EBI-2902553|ensembl:ENSP00000337353|ensembl:ENSP00000377099|uniprotkb:Q2HXX4|uniprotkb:Q96BK7|uniprotkb:Q9NZM7|uniprotkb:Q9NZM8|uniprotkb:Q86TV8	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:tydp1_human(display_long)|uniprotkb:TDP1(gene name)|psi-mi:TDP1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Das et al. (2009)	pubmed:19851285|imex:IM-13895|mint:MINT-7542621|doi:10.1038/emboj.2009.302	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7537433|mint:MINT-7543535|imex:IM-13895-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757|mint:MINT-7543557(identity)	ensembl:ENSG00000042088(gene)|ensembl:ENST00000335725(transcript)|ensembl:ENST00000393454(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0017005"(3'-tyrosyl-DNA phosphodiesterase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010347(Tyrosyl-DNA phosphodiesterase)|mint:Q9NUW8|rcsb pdb:1JY1|rcsb pdb:1MU7|rcsb pdb:1MU9|rcsb pdb:1NOP|rcsb pdb:1QZQ|rcsb pdb:1RFF|rcsb pdb:1RFI|rcsb pdb:1RG1|rcsb pdb:1RG2|rcsb pdb:1RGT|rcsb pdb:1RGU|rcsb pdb:1RH0|rcsb pdb:5NW9|rcsb pdb:5NWA|rcsb pdb:6DHU|rcsb pdb:6DIE|rcsb pdb:6DIH|rcsb pdb:6DIM|rcsb pdb:6DJD|rcsb pdb:6DJE|rcsb pdb:6DJF|rcsb pdb:6DJG|rcsb pdb:6DJH|rcsb pdb:6DJI|rcsb pdb:6DJJ|rcsb pdb:6MJ5|rcsb pdb:6MYZ|rcsb pdb:6MZ0|rcsb pdb:6N0D|rcsb pdb:6N0N|rcsb pdb:6N0O|rcsb pdb:6N0R|rcsb pdb:6N17|rcsb pdb:6N19|rcsb pdb:6W4R|rcsb pdb:6W7J|rcsb pdb:6W7K|rcsb pdb:6W7L|reactome:R-HSA-5693571|refseq:XP_011535244.1|refseq:XP_011535245.1|refseq:NP_001008744.1|refseq:NP_060789.2|refseq:XP_006720260.1|refseq:XP_006720261.1|refseq:XP_016876928.1|refseq:XP_016876931.1|refseq:XP_016876932.1|refseq:XP_016876933.1|refseq:XP_005267904.1|refseq:XP_005267905.1|mint:MINT-7543539(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f4d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2010/01/12	2014/10/16	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	rogid:7ain8+0TMD1xcADMpcQ0WKn4aIc9606	intact-crc:6B108F712710DAB4|rigid:PICEZXkA0gg9e4uMCB5HelXgGo4	false	phosphorylated residue:1981-1981(MINT-7543561)	phosphorylated residue:81-81(MINT-7543540)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P16104	uniprotkb:Q9NUW8	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-2902553|ensembl:ENSP00000337353|ensembl:ENSP00000377099|uniprotkb:Q2HXX4|uniprotkb:Q96BK7|uniprotkb:Q9NZM7|uniprotkb:Q9NZM8|uniprotkb:Q86TV8	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:tydp1_human(display_long)|uniprotkb:TDP1(gene name)|psi-mi:TDP1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Das et al. (2009)	pubmed:19851285|imex:IM-13895|mint:MINT-7542621|doi:10.1038/emboj.2009.302	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7537504|mint:MINT-7543888|imex:IM-13895-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|mint:MINT-7543890(identity)	ensembl:ENSG00000042088(gene)|ensembl:ENST00000335725(transcript)|ensembl:ENST00000393454(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0017005"(3'-tyrosyl-DNA phosphodiesterase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010347(Tyrosyl-DNA phosphodiesterase)|mint:Q9NUW8|rcsb pdb:1JY1|rcsb pdb:1MU7|rcsb pdb:1MU9|rcsb pdb:1NOP|rcsb pdb:1QZQ|rcsb pdb:1RFF|rcsb pdb:1RFI|rcsb pdb:1RG1|rcsb pdb:1RG2|rcsb pdb:1RGT|rcsb pdb:1RGU|rcsb pdb:1RH0|rcsb pdb:5NW9|rcsb pdb:5NWA|rcsb pdb:6DHU|rcsb pdb:6DIE|rcsb pdb:6DIH|rcsb pdb:6DIM|rcsb pdb:6DJD|rcsb pdb:6DJE|rcsb pdb:6DJF|rcsb pdb:6DJG|rcsb pdb:6DJH|rcsb pdb:6DJI|rcsb pdb:6DJJ|rcsb pdb:6MJ5|rcsb pdb:6MYZ|rcsb pdb:6MZ0|rcsb pdb:6N0D|rcsb pdb:6N0N|rcsb pdb:6N0O|rcsb pdb:6N0R|rcsb pdb:6N17|rcsb pdb:6N19|rcsb pdb:6W4R|rcsb pdb:6W7J|rcsb pdb:6W7K|rcsb pdb:6W7L|reactome:R-HSA-5693571|refseq:XP_011535244.1|refseq:XP_011535245.1|refseq:NP_001008744.1|refseq:NP_060789.2|refseq:XP_006720260.1|refseq:XP_006720261.1|refseq:XP_016876928.1|refseq:XP_016876931.1|refseq:XP_016876932.1|refseq:XP_016876933.1|refseq:XP_005267904.1|refseq:XP_005267905.1|mint:MINT-7543892(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2010/01/12	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:7ain8+0TMD1xcADMpcQ0WKn4aIc9606	intact-crc:DEA11CB4CC1C3865|rigid:aedFQQHxhPUmf2dME6ptMXSvSr0	false	-	phosphorylated residue:81-81(MINT-7543893)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P16104	uniprotkb:P18887	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Das et al. (2009)	pubmed:19851285|imex:IM-13895|mint:MINT-7542621|doi:10.1038/emboj.2009.302	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7537454|mint:MINT-7543857|imex:IM-13895-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|mint:MINT-7543859(identity)	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210|mint:MINT-7543870(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f6c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2010/01/12	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	intact-crc:6C3412685C46A83D|rigid:7zU4MUaat9AnLGQDJNMCmPzC984	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P16104	uniprotkb:Q9NUW8	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-2902553|ensembl:ENSP00000337353|ensembl:ENSP00000377099|uniprotkb:Q2HXX4|uniprotkb:Q96BK7|uniprotkb:Q9NZM7|uniprotkb:Q9NZM8|uniprotkb:Q86TV8	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:tydp1_human(display_long)|uniprotkb:TDP1(gene name)|psi-mi:TDP1(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Das et al. (2009)	pubmed:19851285|imex:IM-13895|mint:MINT-7542621|doi:10.1038/emboj.2009.302	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7537568|mint:MINT-7543405|imex:IM-13895-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|mint:MINT-7543408(identity)	ensembl:ENSG00000042088(gene)|ensembl:ENST00000335725(transcript)|ensembl:ENST00000393454(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0017005"(3'-tyrosyl-DNA phosphodiesterase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010347(Tyrosyl-DNA phosphodiesterase)|mint:Q9NUW8|rcsb pdb:1JY1|rcsb pdb:1MU7|rcsb pdb:1MU9|rcsb pdb:1NOP|rcsb pdb:1QZQ|rcsb pdb:1RFF|rcsb pdb:1RFI|rcsb pdb:1RG1|rcsb pdb:1RG2|rcsb pdb:1RGT|rcsb pdb:1RGU|rcsb pdb:1RH0|rcsb pdb:5NW9|rcsb pdb:5NWA|rcsb pdb:6DHU|rcsb pdb:6DIE|rcsb pdb:6DIH|rcsb pdb:6DIM|rcsb pdb:6DJD|rcsb pdb:6DJE|rcsb pdb:6DJF|rcsb pdb:6DJG|rcsb pdb:6DJH|rcsb pdb:6DJI|rcsb pdb:6DJJ|rcsb pdb:6MJ5|rcsb pdb:6MYZ|rcsb pdb:6MZ0|rcsb pdb:6N0D|rcsb pdb:6N0N|rcsb pdb:6N0O|rcsb pdb:6N0R|rcsb pdb:6N17|rcsb pdb:6N19|rcsb pdb:6W4R|rcsb pdb:6W7J|rcsb pdb:6W7K|rcsb pdb:6W7L|reactome:R-HSA-5693571|refseq:XP_011535244.1|refseq:XP_011535245.1|refseq:NP_001008744.1|refseq:NP_060789.2|refseq:XP_006720260.1|refseq:XP_006720261.1|refseq:XP_016876928.1|refseq:XP_016876931.1|refseq:XP_016876932.1|refseq:XP_016876933.1|refseq:XP_005267904.1|refseq:XP_005267905.1|mint:MINT-7543407(identity)	go:"GO:0005730"(nucleolus)	-	-	comment:homomint|comment:mint|figure legend:f3c f3d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-lymphocyte)|taxid:9606(Homo sapiens)	-	2010/01/12	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:7ain8+0TMD1xcADMpcQ0WKn4aIc9606	intact-crc:CAE51FD02A9D98EB|rigid:aedFQQHxhPUmf2dME6ptMXSvSr0	false	-	phosphorylated residue:81-81(MINT-7543502)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P18887	uniprotkb:Q9NUW8	intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887	intact:EBI-2902553|ensembl:ENSP00000337353|ensembl:ENSP00000377099|uniprotkb:Q2HXX4|uniprotkb:Q96BK7|uniprotkb:Q9NZM7|uniprotkb:Q9NZM8|uniprotkb:Q86TV8	psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym)	psi-mi:tydp1_human(display_long)|uniprotkb:TDP1(gene name)|psi-mi:TDP1(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Das et al. (2009)	pubmed:19851285|imex:IM-13895|mint:MINT-7542621|doi:10.1038/emboj.2009.302	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7537773|mint:MINT-7543877|imex:IM-13895-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210|mint:MINT-7543880(identity)	ensembl:ENSG00000042088(gene)|ensembl:ENST00000335725(transcript)|ensembl:ENST00000393454(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0017005"(3'-tyrosyl-DNA phosphodiesterase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010347(Tyrosyl-DNA phosphodiesterase)|mint:Q9NUW8|rcsb pdb:1JY1|rcsb pdb:1MU7|rcsb pdb:1MU9|rcsb pdb:1NOP|rcsb pdb:1QZQ|rcsb pdb:1RFF|rcsb pdb:1RFI|rcsb pdb:1RG1|rcsb pdb:1RG2|rcsb pdb:1RGT|rcsb pdb:1RGU|rcsb pdb:1RH0|rcsb pdb:5NW9|rcsb pdb:5NWA|rcsb pdb:6DHU|rcsb pdb:6DIE|rcsb pdb:6DIH|rcsb pdb:6DIM|rcsb pdb:6DJD|rcsb pdb:6DJE|rcsb pdb:6DJF|rcsb pdb:6DJG|rcsb pdb:6DJH|rcsb pdb:6DJI|rcsb pdb:6DJJ|rcsb pdb:6MJ5|rcsb pdb:6MYZ|rcsb pdb:6MZ0|rcsb pdb:6N0D|rcsb pdb:6N0N|rcsb pdb:6N0O|rcsb pdb:6N0R|rcsb pdb:6N17|rcsb pdb:6N19|rcsb pdb:6W4R|rcsb pdb:6W7J|rcsb pdb:6W7K|rcsb pdb:6W7L|reactome:R-HSA-5693571|refseq:XP_011535244.1|refseq:XP_011535245.1|refseq:NP_001008744.1|refseq:NP_060789.2|refseq:XP_006720260.1|refseq:XP_006720261.1|refseq:XP_016876928.1|refseq:XP_016876931.1|refseq:XP_016876932.1|refseq:XP_016876933.1|refseq:XP_005267904.1|refseq:XP_005267905.1|mint:MINT-7543879(identity)	-	-	-	figure legend:f6a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2010/01/12	2014/10/16	rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606	rogid:7ain8+0TMD1xcADMpcQ0WKn4aIc9606	intact-crc:679FFD121E473DCC|rigid:O8yApzAJMt++2glChlxob8W+w/k	false	-	mutation decreasing interaction:81-81(MINT-7555531)|flag tag:?-?(MINT-7543882)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)