#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:F1LXJ9 uniprotkb:P15146 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 intact:EBI-6095638 psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:mtap2_rat(display_long)|uniprotkb:Map2(gene name)|psi-mi:Map2(display_short)|uniprotkb:Mtap2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7280953|mint:MINT-7986530|imex:IM-14604-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7986532(identity) interpro:IPR030797|refseq:XP_008765430.1|mint:P15146|rgd:3044|interpro:IPR013588(MAP2/Tau projection)|interpro:IPR001084(Tubulin-binding Tau protein)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043203"(axon hillock)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|go:"GO:0097442"(CA3 pyramidal cell dendrite)|go:"GO:0150001"(primary dendrite)|go:"GO:0150002"(distal dendrite)|go:"GO:0150014"(apical distal dendrite)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1903744"(positive regulation of anterograde synaptic vesicle transport)|go:"GO:1903827"|go:"GO:1904527"(negative regulation of microtubule binding)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990769"(proximal neuron projection)|go:"GO:2000575"(obsolete negative regulation of microtubule motor activity)|go:"GO:0034399"(nuclear periphery)|mint:MINT-7989041(identity) - comment:mint - comment:mint|figure legend:f1h|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/07/27 2014/10/16 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 rogid:idoGPInRds+FBHZ23KyNC+c5gL810116 intact-crc:38F4F21DD9523F07|rigid:5LUtvciy95aOoezY/l2R1fGCarU false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q62634 uniprotkb:O14522 intact:EBI-7280977|intact:MINT-4784487|uniprotkb:A9LRT0|ensembl:ENSRNOP00000028064 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:vglu1_rat(display_long)|uniprotkb:Slc17a7(gene name)|psi-mi:Slc17a7(display_short)|uniprotkb:Bnpi(gene name synonym)|uniprotkb:Vglut1(gene name synonym)|uniprotkb:Solute carrier family 17 member 7(gene name synonym)|uniprotkb:"Brain-specific Na(+)-dependent inorganic phosphate cotransporter"(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7281012|mint:MINT-7989031|imex:IM-14604-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:620101|refseq:NP_446311.1|ensembl:ENSRNOG00000020650(gene)|ensembl:ENSRNOT00000028064(transcript)|go:"GO:0003407"(neural retina development)|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0006817"(phosphate ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007420"(brain development)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008068"(extracellularly glutamate-gated chloride channel activity)|go:"GO:0015319"("sodium:inorganic phosphate symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042137"(sequestering of neurotransmitter)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0051938"(L-glutamate import)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0097401"(synaptic vesicle lumen acidification)|go:"GO:0098700"(neurotransmitter loading into synaptic vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|mint:Q62634|reactome:R-RNO-210500|reactome:R-RNO-428643|go:"GO:0006820"(anion transport)|mint:MINT-7989033(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989035(identity) - comment:mint - comment:homomint|figure legend:f1m|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/07/27 2014/10/16 rogid:UbaEJLA0CIT48OoJn8wT3wgvP1s10116 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:E0E63E441B828027|rigid:BXFPRXPU0rRMGyuqpIHYdIDwdKU false - green fluorescent protein tag:?-?(MINT-7989036) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O14522 uniprotkb:P31016 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 intact:EBI-375655|uniprotkb:P97631|ensembl:ENSRNOP00000059045 psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:dlg4_rat(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:Psd95(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7280963|mint:MINT-7988936|imex:IM-14604-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7988938(identity) go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|rcsb pdb:1TP3|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P31016|rcsb pdb:1BE9|rcsb pdb:1BFE|rcsb pdb:1IU0|rcsb pdb:1IU2|rcsb pdb:1JXM|rcsb pdb:1JXO|rcsb pdb:1KJW|rcsb pdb:1QLC|rcsb pdb:1RGR|rcsb pdb:5MZ7|rcsb pdb:5W72|rcsb pdb:5YPO|rcsb pdb:5YPR|rcsb pdb:7CQF|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-451308|reactome:R-RNO-5625900|reactome:R-RNO-5673001|reactome:R-RNO-5682910|reactome:R-RNO-6794361|reactome:R-RNO-8849932|rcsb pdb:1TP5|rcsb pdb:1TQ3|rcsb pdb:2KA9|rcsb pdb:2MHO|rcsb pdb:2XKX|rcsb pdb:3GSL|rcsb pdb:3WP0|rcsb pdb:3WP1|rcsb pdb:5B64|rcsb pdb:5D13|rcsb pdb:5GNV|rcsb pdb:5HDY|rcsb pdb:5HEB|rcsb pdb:5HED|rcsb pdb:5HET|rcsb pdb:5HEY|rcsb pdb:5HF1|rcsb pdb:5HF4|rcsb pdb:5HFB|rcsb pdb:5HFC|rcsb pdb:5HFD|rcsb pdb:5HFE|rcsb pdb:5HFF|ensembl:ENSRNOG00000018526(gene)|ensembl:ENSRNOT00000068493(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|rgd:68424|refseq:NP_062567.1|dip:DIP-29264N|mint:MINT-7988939(identity) - - - comment:homomint|figure legend:f1m|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/07/27 2014/10/16 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 rogid:4oWbxT/HVvWQqdbFqt3htRuQNpw10116 intact-crc:D286A8C7D17DDE97|rigid:g0mF2Nb3AFPiV5puyUa42F8KbsQ false green fluorescent protein tag:?-?(MINT-7989026) - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0422"(immunostaining) uniprotkb:F1LXJ9 uniprotkb:P07825 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 intact:EBI-976085|uniprotkb:Q499R3 psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:syph_rat(display_long)|uniprotkb:Major synaptic vesicle protein p38(gene name synonym)|uniprotkb:Syp(gene name)|psi-mi:Syp(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7281026|mint:MINT-7989047|imex:IM-14604-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7989051(identity) go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0060076"(excitatory synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0042734"(presynaptic membrane)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0000149"(SNARE binding)|go:"GO:0006897"(endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|rgd:3802|refseq:NP_036796.1|interpro:IPR008253(Marvel)|interpro:IPR001285(Synaptophysin/synaptoporin)|interpro:IPR028714|mint:P07825|mint:MINT-7989049(identity) - comment:mint - comment:mint|figure legend:f1k|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/07/27 2014/10/16 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 rogid:nG9lA5IrA7dLVQ2QlJ7VhtruLLg10116 intact-crc:E15DA0C475D00542|rigid:GLppkRTfS9mrmNNgOh8Ex+wS5Iw false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:O35458 uniprotkb:O14522 intact:EBI-7281062|intact:UNK-5362087|ensembl:ENSRNOP00000020720 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:viaat_rat(display_long)|uniprotkb:Slc32a1(gene name)|psi-mi:Slc32a1(display_short)|uniprotkb:Vgat(gene name synonym)|uniprotkb:Viaat(gene name synonym)|uniprotkb:GABA and glycine transporter(gene name synonym)|uniprotkb:Vesicular GABA transporter(gene name synonym)|uniprotkb:Solute carrier family 32 member 1(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7281090|mint:MINT-7989080|imex:IM-14604-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006235503.1|refseq:NP_113970.1|rgd:621402|ensembl:ENSRNOG00000015393(gene)|ensembl:ENSRNOT00000020720(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007568"(aging)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015187"(glycine transmembrane transporter activity)|go:"GO:0015495"("gamma-aminobutyric acid:proton symporter activity")|go:"GO:0015812"(gamma-aminobutyric acid transport)|go:"GO:0015816"(glycine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0043005"(neuron projection)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044292"(dendrite terminus)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044316"(cone cell pedicle)|go:"GO:0045202"(synapse)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051286"(cell tip)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0098700"(neurotransmitter loading into synaptic vesicle)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR013057(Amino acid transporter, transmembrane)|mint:O35458|reactome:R-RNO-425393|reactome:R-RNO-888590|mint:MINT-7989082(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989084(identity) - function:Involved in the uptake of GABA and glycine into the synaptic vesicles|comment:mint - comment:homomint|comment:mint|figure legend:f1n|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/07/27 2014/10/16 rogid:yejLVaYBDG3n2gt6XV8lN868NYk10116 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:20C5A75D1B156BBD|rigid:MyFAC461wq8Mcttc/zWO/FIVDWI false - green fluorescent protein tag:?-?(MINT-7989085) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:F1LXJ9 uniprotkb:P31016 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 intact:EBI-375655|uniprotkb:P97631|ensembl:ENSRNOP00000059045 psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:dlg4_rat(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:Psd95(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7281051|mint:MINT-7989057|imex:IM-14604-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7989061(identity) go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|rcsb pdb:1TP3|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P31016|rcsb pdb:1BE9|rcsb pdb:1BFE|rcsb pdb:1IU0|rcsb pdb:1IU2|rcsb pdb:1JXM|rcsb pdb:1JXO|rcsb pdb:1KJW|rcsb pdb:1QLC|rcsb pdb:1RGR|rcsb pdb:5MZ7|rcsb pdb:5W72|rcsb pdb:5YPO|rcsb pdb:5YPR|rcsb pdb:7CQF|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-451308|reactome:R-RNO-5625900|reactome:R-RNO-5673001|reactome:R-RNO-5682910|reactome:R-RNO-6794361|reactome:R-RNO-8849932|rcsb pdb:1TP5|rcsb pdb:1TQ3|rcsb pdb:2KA9|rcsb pdb:2MHO|rcsb pdb:2XKX|rcsb pdb:3GSL|rcsb pdb:3WP0|rcsb pdb:3WP1|rcsb pdb:5B64|rcsb pdb:5D13|rcsb pdb:5GNV|rcsb pdb:5HDY|rcsb pdb:5HEB|rcsb pdb:5HED|rcsb pdb:5HET|rcsb pdb:5HEY|rcsb pdb:5HF1|rcsb pdb:5HF4|rcsb pdb:5HFB|rcsb pdb:5HFC|rcsb pdb:5HFD|rcsb pdb:5HFE|rcsb pdb:5HFF|ensembl:ENSRNOG00000018526(gene)|ensembl:ENSRNOT00000068493(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|rgd:68424|refseq:NP_062567.1|dip:DIP-29264N|mint:MINT-7989059(identity) go:"GO:0043197"(dendritic spine) comment:mint - comment:mint|figure legend:f1j|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/07/27 2014/10/16 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 rogid:4oWbxT/HVvWQqdbFqt3htRuQNpw10116 intact-crc:125E56BDA46E9606|rigid:WgeqltPdWRdCl1dTXqkihS/3VqM false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q62765 uniprotkb:O14522 intact:EBI-7281118|intact:MINT-1526995|ensembl:ENSRNOP00000075793 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nlgn1_rat(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Neuroligin I(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7281181|mint:MINT-7989191|imex:IM-14604-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:621117|refseq:NP_446320.1|refseq:XP_017446075.1|refseq:XP_017446076.1|refseq:XP_017446077.1|refseq:XP_017446078.1|refseq:XP_017446079.1|refseq:XP_017446072.1|refseq:XP_017446073.1|refseq:XP_017446074.1|ensembl:ENSRNOG00000032576(gene)|ensembl:ENSRNOT00000092660(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:3BIW|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|rcsb pdb:3BIX|rcsb pdb:3VKF|reactome:R-RNO-6794361|dip:DIP-44832N|mint:MINT-7989193(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989195(identity) - comment:mint|function:"Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses" - comment:homomint|comment:mint|figure legend:f7d|comment:Co-expression of fyn decrease the colocalization.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/07/27 2014/10/16 rogid:I6UajYCOkz8f+3nt2IHH2rOCby810116 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:FD4284B2FB7C5F15|rigid:3QUCYUMHncs/VbUF1XJS+1164WY false - green fluorescent protein tag:?-?(MINT-7989196) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q03555 uniprotkb:O14522 intact:EBI-349317 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:geph_rat(display_long)|uniprotkb:Gphn(gene name)|psi-mi:Gphn(display_short)|uniprotkb:Gph(gene name synonym)|uniprotkb:Putative glycine receptor-tubulin linker protein(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7281104|mint:MINT-7989092|imex:IM-14604-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:69194|refseq:NP_074056.2|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006605"(protein targeting)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR038987|interpro:IPR036688|rcsb pdb:1IHC|rcsb pdb:1T3E|rcsb pdb:2FTS|rcsb pdb:2FU3|rcsb pdb:4PD0|rcsb pdb:4PD1|rcsb pdb:4TK1|rcsb pdb:4TK2|rcsb pdb:4TK3|rcsb pdb:4TK4|rcsb pdb:4U90|rcsb pdb:4U91|rcsb pdb:5ERQ|rcsb pdb:5ERR|rcsb pdb:5ERS|rcsb pdb:5ERT|rcsb pdb:5ERU|rcsb pdb:5ERV|rcsb pdb:6FGC|rcsb pdb:6FGD|rcsb pdb:6HSN|rcsb pdb:6HSO|dip:DIP-33263N|reactome:R-RNO-947581|mint:MINT-7989094(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989096(identity) - - - comment:homomint|comment:mint|figure legend:f1n|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/07/27 2014/10/16 rogid:br2qzn9/bl+2scl7L+bezsDWHFs10116 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:14618446CFB476B0|rigid:n6RXagtzAMHebpvKt73bR4ENogg false - green fluorescent protein tag:?-?(MINT-7989097) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:F1LXJ9 uniprotkb:P47819 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 intact:EBI-931216|uniprotkb:Q7TQ31|uniprotkb:Q9R1Q3|uniprotkb:Q9Z2S0|uniprotkb:A7REI0|ensembl:ENSRNOP00000032389 psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:gfap_rat(display_long)|uniprotkb:Gfap(gene name)|psi-mi:Gfap(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7281205|mint:MINT-7989068|imex:IM-14604-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7989073(identity) rgd:2679|refseq:NP_058705.2|ensembl:ENSRNOG00000002919(gene)|ensembl:ENSRNOT00000034401(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009611"(response to wounding)|go:"GO:0010467"(gene expression)|go:"GO:0010625"(positive regulation of Schwann cell proliferation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0045103"(intermediate filament-based process)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027701|interpro:IPR039008|mint:P47819|mint:MINT-7989071(identity) - comment:mint - comment:mint|figure legend:f1i|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-astrocyte)|taxid:10116(Rattus norvegicus astrocyte) - 2010/07/27 2014/10/16 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 rogid:ougdJqiJZjrvDV1vfVnCwcx9cFU10116 intact-crc:7816490893E32C2C|rigid:T+REa/Hn+uDE+ucNKjB41E2tMw0 false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:F1LXJ9 uniprotkb:Q63374 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 intact:EBI-7281259|uniprotkb:Q63375|intact:MINT-1538394 psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:nrx2a_rat(display_long)|uniprotkb:Nrxn2(gene name)|psi-mi:Nrxn2(display_short)|uniprotkb:Neurexin II-alpha(gene name synonym)|uniprotkb:Neurexin-2-alpha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281297|mint:MINT-7989102|imex:IM-14604-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7989107(identity) refseq:NP_446298.1|rgd:620211|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030534"(adult behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098793"(presynapse)|reactome:R-RNO-6794361|mint:MINT-7989114(identity) - comment:mint comment:mint|function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 rogid:+QIN2WVx57oT7k7G1F79o2bw2HY10116 intact-crc:D66E929474056A7E|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:F1LXJ9 uniprotkb:Q62888 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 intact:EBI-7281302|intact:MINT-1891708 psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:nlgn2_rat(display_long)|uniprotkb:Nlgn2(gene name)|psi-mi:Nlgn2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281297|mint:MINT-7989102|imex:IM-14604-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7989107(identity) interpro:IPR030023|rgd:621118|refseq:NP_446444.1|interpro:IPR019819|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|go:"GO:0001966"(thigmotaxis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007630"(jump response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0072553"(terminal button organization)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1904034"(positive regulation of t-SNARE clustering)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|interpro:IPR029058|rcsb pdb:5V5V|reactome:R-RNO-6794361|mint:MINT-7989110(identity) - comment:mint comment:mint|function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 rogid:HlzMKXRXR/YD08sdzWZiyGs2g6A10116 intact-crc:D66E929474056A7E|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:F1LXJ9 uniprotkb:P31016 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 intact:EBI-375655|uniprotkb:P97631|ensembl:ENSRNOP00000059045 psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:dlg4_rat(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:Psd95(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281297|mint:MINT-7989102|imex:IM-14604-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7989107(identity) go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|rcsb pdb:1TP3|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P31016|rcsb pdb:1BE9|rcsb pdb:1BFE|rcsb pdb:1IU0|rcsb pdb:1IU2|rcsb pdb:1JXM|rcsb pdb:1JXO|rcsb pdb:1KJW|rcsb pdb:1QLC|rcsb pdb:1RGR|rcsb pdb:5MZ7|rcsb pdb:5W72|rcsb pdb:5YPO|rcsb pdb:5YPR|rcsb pdb:7CQF|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-451308|reactome:R-RNO-5625900|reactome:R-RNO-5673001|reactome:R-RNO-5682910|reactome:R-RNO-6794361|reactome:R-RNO-8849932|rcsb pdb:1TP5|rcsb pdb:1TQ3|rcsb pdb:2KA9|rcsb pdb:2MHO|rcsb pdb:2XKX|rcsb pdb:3GSL|rcsb pdb:3WP0|rcsb pdb:3WP1|rcsb pdb:5B64|rcsb pdb:5D13|rcsb pdb:5GNV|rcsb pdb:5HDY|rcsb pdb:5HEB|rcsb pdb:5HED|rcsb pdb:5HET|rcsb pdb:5HEY|rcsb pdb:5HF1|rcsb pdb:5HF4|rcsb pdb:5HFB|rcsb pdb:5HFC|rcsb pdb:5HFD|rcsb pdb:5HFE|rcsb pdb:5HFF|ensembl:ENSRNOG00000018526(gene)|ensembl:ENSRNOT00000068493(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|rgd:68424|refseq:NP_062567.1|dip:DIP-29264N|mint:MINT-7989105(identity) - comment:mint - figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 rogid:4oWbxT/HVvWQqdbFqt3htRuQNpw10116 intact-crc:D66E929474056A7E|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:F1LXJ9 uniprotkb:Q62915 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 intact:EBI-704635 psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:cskp_rat(display_long)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Cask(gene name)|psi-mi:Cask(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281297|mint:MINT-7989102|imex:IM-14604-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7989107(identity) rgd:62004|refseq:NP_071520.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR011009(Protein kinase-like)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|rcsb pdb:1RSO|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-RNO-212676|reactome:R-RNO-6794361|rcsb pdb:6LNM|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098846"(podocyte foot)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|mint:MINT-7989111(identity) - comment:mint - figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 rogid:S7T42QMExgUKMZpBQEJNjQeR9ZE10116 intact-crc:D66E929474056A7E|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:F1LXJ9 uniprotkb:O88382 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 intact:EBI-696179|uniprotkb:Q9R271 psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281297|mint:MINT-7989102|imex:IM-14604-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7989107(identity) rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-7989122(identity) - comment:mint - figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116 intact-crc:D66E929474056A7E|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q63374 uniprotkb:F1LXJ9 intact:EBI-7281259|uniprotkb:Q63375|intact:MINT-1538394 intact:EBI-7280928|intact:MINT-7988941|ensembl:ENSRNOP00000041324 psi-mi:nrx2a_rat(display_long)|uniprotkb:Nrxn2(gene name)|psi-mi:Nrxn2(display_short)|uniprotkb:Neurexin II-alpha(gene name synonym)|uniprotkb:Neurexin-2-alpha(gene name synonym) psi-mi:f1lxj9_rat(display_long)|uniprotkb:Ptprt(gene name)|psi-mi:Ptprt(display_short)|uniprotkb:Ptprt_predicted(gene name synonym)|uniprotkb:rCG_32138(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281362|mint:MINT-7989126|imex:IM-14604-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_446298.1|rgd:620211|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030534"(adult behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098793"(presynapse)|reactome:R-RNO-6794361|mint:MINT-7989130(identity) refseq:NP_001102073.1|rgd:1309653|ensembl:ENSRNOG00000032656(gene)|ensembl:ENSRNOT00000044466(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:MINT-7989136(identity) - comment:mint|function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling comment:mint figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:+QIN2WVx57oT7k7G1F79o2bw2HY10116 rogid:uIlbCTVXvAMRX16u0s2wY96K5ks10116 intact-crc:261575BAD1263DF0|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q63374 uniprotkb:Q62888 intact:EBI-7281259|uniprotkb:Q63375|intact:MINT-1538394 intact:EBI-7281302|intact:MINT-1891708 psi-mi:nrx2a_rat(display_long)|uniprotkb:Nrxn2(gene name)|psi-mi:Nrxn2(display_short)|uniprotkb:Neurexin II-alpha(gene name synonym)|uniprotkb:Neurexin-2-alpha(gene name synonym) psi-mi:nlgn2_rat(display_long)|uniprotkb:Nlgn2(gene name)|psi-mi:Nlgn2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281362|mint:MINT-7989126|imex:IM-14604-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_446298.1|rgd:620211|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030534"(adult behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098793"(presynapse)|reactome:R-RNO-6794361|mint:MINT-7989130(identity) interpro:IPR030023|rgd:621118|refseq:NP_446444.1|interpro:IPR019819|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|go:"GO:0001966"(thigmotaxis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007630"(jump response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0072553"(terminal button organization)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1904034"(positive regulation of t-SNARE clustering)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|interpro:IPR029058|rcsb pdb:5V5V|reactome:R-RNO-6794361|mint:MINT-7989134(identity) - comment:mint|function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling comment:mint|function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:+QIN2WVx57oT7k7G1F79o2bw2HY10116 rogid:HlzMKXRXR/YD08sdzWZiyGs2g6A10116 intact-crc:261575BAD1263DF0|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q63374 uniprotkb:Q62915 intact:EBI-7281259|uniprotkb:Q63375|intact:MINT-1538394 intact:EBI-704635 psi-mi:nrx2a_rat(display_long)|uniprotkb:Nrxn2(gene name)|psi-mi:Nrxn2(display_short)|uniprotkb:Neurexin II-alpha(gene name synonym)|uniprotkb:Neurexin-2-alpha(gene name synonym) psi-mi:cskp_rat(display_long)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Cask(gene name)|psi-mi:Cask(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281362|mint:MINT-7989126|imex:IM-14604-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_446298.1|rgd:620211|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030534"(adult behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098793"(presynapse)|reactome:R-RNO-6794361|mint:MINT-7989130(identity) rgd:62004|refseq:NP_071520.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR011009(Protein kinase-like)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|rcsb pdb:1RSO|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-RNO-212676|reactome:R-RNO-6794361|rcsb pdb:6LNM|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098846"(podocyte foot)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|mint:MINT-7989132(identity) - comment:mint|function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling - figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:+QIN2WVx57oT7k7G1F79o2bw2HY10116 rogid:S7T42QMExgUKMZpBQEJNjQeR9ZE10116 intact-crc:261575BAD1263DF0|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q63374 uniprotkb:P31016 intact:EBI-7281259|uniprotkb:Q63375|intact:MINT-1538394 intact:EBI-375655|uniprotkb:P97631|ensembl:ENSRNOP00000059045 psi-mi:nrx2a_rat(display_long)|uniprotkb:Nrxn2(gene name)|psi-mi:Nrxn2(display_short)|uniprotkb:Neurexin II-alpha(gene name synonym)|uniprotkb:Neurexin-2-alpha(gene name synonym) psi-mi:dlg4_rat(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:Psd95(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281362|mint:MINT-7989126|imex:IM-14604-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_446298.1|rgd:620211|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030534"(adult behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098793"(presynapse)|reactome:R-RNO-6794361|mint:MINT-7989130(identity) go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|rcsb pdb:1TP3|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P31016|rcsb pdb:1BE9|rcsb pdb:1BFE|rcsb pdb:1IU0|rcsb pdb:1IU2|rcsb pdb:1JXM|rcsb pdb:1JXO|rcsb pdb:1KJW|rcsb pdb:1QLC|rcsb pdb:1RGR|rcsb pdb:5MZ7|rcsb pdb:5W72|rcsb pdb:5YPO|rcsb pdb:5YPR|rcsb pdb:7CQF|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-451308|reactome:R-RNO-5625900|reactome:R-RNO-5673001|reactome:R-RNO-5682910|reactome:R-RNO-6794361|reactome:R-RNO-8849932|rcsb pdb:1TP5|rcsb pdb:1TQ3|rcsb pdb:2KA9|rcsb pdb:2MHO|rcsb pdb:2XKX|rcsb pdb:3GSL|rcsb pdb:3WP0|rcsb pdb:3WP1|rcsb pdb:5B64|rcsb pdb:5D13|rcsb pdb:5GNV|rcsb pdb:5HDY|rcsb pdb:5HEB|rcsb pdb:5HED|rcsb pdb:5HET|rcsb pdb:5HEY|rcsb pdb:5HF1|rcsb pdb:5HF4|rcsb pdb:5HFB|rcsb pdb:5HFC|rcsb pdb:5HFD|rcsb pdb:5HFE|rcsb pdb:5HFF|ensembl:ENSRNOG00000018526(gene)|ensembl:ENSRNOT00000068493(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|rgd:68424|refseq:NP_062567.1|dip:DIP-29264N|mint:MINT-7989138(identity) - comment:mint|function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling - figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:+QIN2WVx57oT7k7G1F79o2bw2HY10116 rogid:4oWbxT/HVvWQqdbFqt3htRuQNpw10116 intact-crc:261575BAD1263DF0|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q63374 uniprotkb:O88382 intact:EBI-7281259|uniprotkb:Q63375|intact:MINT-1538394 intact:EBI-696179|uniprotkb:Q9R271 psi-mi:nrx2a_rat(display_long)|uniprotkb:Nrxn2(gene name)|psi-mi:Nrxn2(display_short)|uniprotkb:Neurexin II-alpha(gene name synonym)|uniprotkb:Neurexin-2-alpha(gene name synonym) psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7281362|mint:MINT-7989126|imex:IM-14604-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_446298.1|rgd:620211|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030534"(adult behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098793"(presynapse)|reactome:R-RNO-6794361|mint:MINT-7989130(identity) rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-7989128(identity) - comment:mint|function:Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling - figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain synaptosom)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:+QIN2WVx57oT7k7G1F79o2bw2HY10116 rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116 intact-crc:261575BAD1263DF0|rigid:ncWf5q5rJQQj/+mZQR85LF+tqS4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14522 uniprotkb:Q99K10 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 intact:EBI-775037|ensembl:ENSMUSP00000074565|ensembl:ENSMUSP00000142200 psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:nlgn1_mouse(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Kiaa1070(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281424|mint:MINT-7989155|imex:IM-14604-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989159(identity) refseq:NP_619607.2|dip:DIP-32027N|ensembl:ENSMUSG00000063887(gene)|ensembl:ENSMUST00000075054(transcript)|ensembl:ENSMUST00000193603(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|rcsb pdb:3B3Q|reactome:R-MMU-6794361|mint:MINT-7989157(identity) - - - comment:homomint|comment:mint|figure legend:f4e f4f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 rogid:v8ZiOUF8s1yNWhimIoIUHCDdiD810090 intact-crc:289F192F458DE1CA|rigid:NIEJ2GcirIeTYtPjBBVM/ixLHAk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-7281394 uniprotkb:O14522 genbank_protein_gi:62243518|intact:MINT-7989394 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nrx2a(display_short)|psi-mi:EBI-7281394(display_long) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281399|mint:MINT-7989143|imex:IM-14604-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:MINT-7989145(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989147(identity) - comment:mint|no-uniprot-update: - figure legend:f4e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 - rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:F93CA13244C00B04 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q69ZK9 uniprotkb:O14522 intact:EBI-775065|uniprotkb:Q5F288|ensembl:ENSMUSP00000053097|ensembl:ENSMUSP00000104274 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nlgn2_mouse(display_long)|uniprotkb:Nlgn2(gene name)|psi-mi:Nlgn2(display_short)|uniprotkb:Kiaa1366(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281490|mint:MINT-7989222|imex:IM-14604-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_942562.2|refseq:XP_006532964.1|dip:DIP-29702N|ensembl:ENSMUSG00000051790(gene)|ensembl:ENSMUST00000056484(transcript)|ensembl:ENSMUST00000108634(transcript)|go:"GO:0001966"(thigmotaxis)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007630"(jump response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0072553"(terminal button organization)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1904034"(positive regulation of t-SNARE clustering)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030023|mint:Q69ZK9|rcsb pdb:3BL8|reactome:R-MMU-6794361|mint:MINT-7989228(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989224(identity) - - - figure legend:SF6A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:cSlsVbBCCXq2FW64Fa2J4b6apfA10090 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:E79DFDA77227B83C|rigid:epCklt6jfZ29wGe6Rufv9Ze/bE0 false - flag tag:?-?(MINT-7989225) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14522 uniprotkb:O14522 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281456|mint:MINT-7989177|imex:IM-14604-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989181(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989179(identity) - - - figure legend:f7b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:2BAB74647E65A895|rigid:pzaj8ddlLQzpmpeN8mO8orTwdRs false green fluorescent protein tag:?-?(MINT-7989185) flag tag:?-?(MINT-7989188) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14522 uniprotkb:Q9CS84 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 intact:EBI-399696|uniprotkb:O88722|uniprotkb:Q80Y87|uniprotkb:Q8CHE6|uniprotkb:G3UWZ9|ensembl:ENSMUSP00000124116 psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:nrx1a_mouse(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-alpha(gene name synonym)|uniprotkb:Kiaa0578(gene name synonym)|uniprotkb:Neurexin-1-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281519|mint:MINT-7989263|imex:IM-14604-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989267(identity) refseq:NP_064648.3|refseq:NP_796258.2|refseq:XP_006523875.1|refseq:XP_006523874.1|refseq:XP_006523879.1|refseq:NP_001333891.1|ensembl:ENSMUSG00000024109(gene)|ensembl:ENSMUST00000161402(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|rcsb pdb:3BOD|rcsb pdb:3MW2|rcsb pdb:6PNP|rcsb pdb:6PNQ|reactome:R-MMU-6794361|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|mint:MINT-7989265(identity) - - - comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 rogid:/fUMo/ju6izl+U1uBzDw5AaJMU010090 intact-crc:EC3749336127A81B|rigid:kErjQbTBCFW1d0wgXyYU1HxjrJo false - cyan fluorescent protein tag:?-?(MINT-7989330) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) intact:EBI-7281394 uniprotkb:O14522 genbank_protein_gi:62243518|intact:MINT-7989394 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nrx2a(display_short)|psi-mi:EBI-7281394(display_long) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281505|mint:MINT-7989237|imex:IM-14604-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:MINT-7989239(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989241(identity) - comment:mint|no-uniprot-update: - figure legend:SF6B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 - rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:2B3BD572175239CB false - flag tag:?-?(MINT-7989242) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6P9K9 uniprotkb:O14522 intact:EBI-7281557|uniprotkb:E9Q466|intact:MINT-7989389|uniprotkb:E9PW93|intact:MINT-4115192|uniprotkb:Q8CCT8|ensembl:ENSMUSP00000129678 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nrx3a_mouse(display_long)|uniprotkb:Nrxn3(gene name)|psi-mi:Nrxn3(display_short)|uniprotkb:Neurexin III-alpha(gene name synonym)|uniprotkb:Neurexin-3-alpha(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281591|mint:MINT-7989379|imex:IM-14604-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006515620.1|refseq:NP_766132.2|refseq:NP_001185516.2|ensembl:ENSMUSG00000066392(gene)|ensembl:ENSMUST00000163134(transcript)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|mint:Q6P9K9|rcsb pdb:3MW4|reactome:R-MMU-6794361|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|mint:MINT-7989383(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989381(identity) - comment:mint - comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:doHQ/O7sneKAIREyTfP+n+U7axQ10090 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:74ED9513E3985C54|rigid:ebFltlgZrcumU1yDS7zRZytGtUc false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) intact:EBI-7281394 uniprotkb:O14522 genbank_protein_gi:62243518|intact:MINT-7989394 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nrx2a(display_short)|psi-mi:EBI-7281394(display_long) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281547|mint:MINT-7989369|imex:IM-14604-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:MINT-7989371(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989375(identity) - comment:mint|no-uniprot-update: - comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 - rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:40DCA6D36078B8EB false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P31016 uniprotkb:Q62765 intact:EBI-375655|uniprotkb:P97631|ensembl:ENSRNOP00000059045 intact:EBI-7281118|intact:MINT-1526995|ensembl:ENSRNOP00000075793 psi-mi:dlg4_rat(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:Psd95(gene name synonym) psi-mi:nlgn1_rat(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Neuroligin I(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7281610|mint:MINT-7989163|imex:IM-14604-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|rcsb pdb:1TP3|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P31016|rcsb pdb:1BE9|rcsb pdb:1BFE|rcsb pdb:1IU0|rcsb pdb:1IU2|rcsb pdb:1JXM|rcsb pdb:1JXO|rcsb pdb:1KJW|rcsb pdb:1QLC|rcsb pdb:1RGR|rcsb pdb:5MZ7|rcsb pdb:5W72|rcsb pdb:5YPO|rcsb pdb:5YPR|rcsb pdb:7CQF|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-451308|reactome:R-RNO-5625900|reactome:R-RNO-5673001|reactome:R-RNO-5682910|reactome:R-RNO-6794361|reactome:R-RNO-8849932|rcsb pdb:1TP5|rcsb pdb:1TQ3|rcsb pdb:2KA9|rcsb pdb:2MHO|rcsb pdb:2XKX|rcsb pdb:3GSL|rcsb pdb:3WP0|rcsb pdb:3WP1|rcsb pdb:5B64|rcsb pdb:5D13|rcsb pdb:5GNV|rcsb pdb:5HDY|rcsb pdb:5HEB|rcsb pdb:5HED|rcsb pdb:5HET|rcsb pdb:5HEY|rcsb pdb:5HF1|rcsb pdb:5HF4|rcsb pdb:5HFB|rcsb pdb:5HFC|rcsb pdb:5HFD|rcsb pdb:5HFE|rcsb pdb:5HFF|ensembl:ENSRNOG00000018526(gene)|ensembl:ENSRNOT00000068493(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|rgd:68424|refseq:NP_062567.1|dip:DIP-29264N|mint:MINT-7989165(identity) rgd:621117|refseq:NP_446320.1|refseq:XP_017446075.1|refseq:XP_017446076.1|refseq:XP_017446077.1|refseq:XP_017446078.1|refseq:XP_017446079.1|refseq:XP_017446072.1|refseq:XP_017446073.1|refseq:XP_017446074.1|ensembl:ENSRNOG00000032576(gene)|ensembl:ENSRNOT00000092660(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:3BIW|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|rcsb pdb:3BIX|rcsb pdb:3VKF|reactome:R-RNO-6794361|dip:DIP-44832N|mint:MINT-7989174(identity) - - comment:mint|function:"Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses" figure legend:f4g|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:4oWbxT/HVvWQqdbFqt3htRuQNpw10116 rogid:I6UajYCOkz8f+3nt2IHH2rOCby810116 intact-crc:D06CF0398526F02D|rigid:EMTvoqifPAguINknYqNvSmkGIZs false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P31016 uniprotkb:O14522 intact:EBI-375655|uniprotkb:P97631|ensembl:ENSRNOP00000059045 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:dlg4_rat(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)|uniprotkb:Psd95(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7281610|mint:MINT-7989163|imex:IM-14604-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|rcsb pdb:1TP3|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:P31016|rcsb pdb:1BE9|rcsb pdb:1BFE|rcsb pdb:1IU0|rcsb pdb:1IU2|rcsb pdb:1JXM|rcsb pdb:1JXO|rcsb pdb:1KJW|rcsb pdb:1QLC|rcsb pdb:1RGR|rcsb pdb:5MZ7|rcsb pdb:5W72|rcsb pdb:5YPO|rcsb pdb:5YPR|rcsb pdb:7CQF|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-451308|reactome:R-RNO-5625900|reactome:R-RNO-5673001|reactome:R-RNO-5682910|reactome:R-RNO-6794361|reactome:R-RNO-8849932|rcsb pdb:1TP5|rcsb pdb:1TQ3|rcsb pdb:2KA9|rcsb pdb:2MHO|rcsb pdb:2XKX|rcsb pdb:3GSL|rcsb pdb:3WP0|rcsb pdb:3WP1|rcsb pdb:5B64|rcsb pdb:5D13|rcsb pdb:5GNV|rcsb pdb:5HDY|rcsb pdb:5HEB|rcsb pdb:5HED|rcsb pdb:5HET|rcsb pdb:5HEY|rcsb pdb:5HF1|rcsb pdb:5HF4|rcsb pdb:5HFB|rcsb pdb:5HFC|rcsb pdb:5HFD|rcsb pdb:5HFE|rcsb pdb:5HFF|ensembl:ENSRNOG00000018526(gene)|ensembl:ENSRNOT00000068493(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|rgd:68424|refseq:NP_062567.1|dip:DIP-29264N|mint:MINT-7989165(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989167(identity) - - - figure legend:f4g|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus) - 2010/07/27 2014/10/16 rogid:4oWbxT/HVvWQqdbFqt3htRuQNpw10116 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:D06CF0398526F02D|rigid:EMTvoqifPAguINknYqNvSmkGIZs false - green fluorescent protein tag:?-?(MINT-7989168) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O14522 uniprotkb:Q69ZK9 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 intact:EBI-775065|uniprotkb:Q5F288|ensembl:ENSMUSP00000053097|ensembl:ENSMUSP00000104274 psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:nlgn2_mouse(display_long)|uniprotkb:Nlgn2(gene name)|psi-mi:Nlgn2(display_short)|uniprotkb:Kiaa1366(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281662|mint:MINT-7989246|imex:IM-14604-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989250(identity) refseq:NP_942562.2|refseq:XP_006532964.1|dip:DIP-29702N|ensembl:ENSMUSG00000051790(gene)|ensembl:ENSMUST00000056484(transcript)|ensembl:ENSMUST00000108634(transcript)|go:"GO:0001966"(thigmotaxis)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007630"(jump response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0072553"(terminal button organization)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1904034"(positive regulation of t-SNARE clustering)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030023|mint:Q69ZK9|rcsb pdb:3BL8|reactome:R-MMU-6794361|mint:MINT-7989248(identity) - - - figure legend:sf3b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 rogid:cSlsVbBCCXq2FW64Fa2J4b6apfA10090 intact-crc:10D41ABC7B40CB99|rigid:epCklt6jfZ29wGe6Rufv9Ze/bE0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q99K10 uniprotkb:O14522 intact:EBI-775037|ensembl:ENSMUSP00000074565|ensembl:ENSMUSP00000142200 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nlgn1_mouse(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Kiaa1070(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281673|mint:MINT-7989255|imex:IM-14604-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_619607.2|dip:DIP-32027N|ensembl:ENSMUSG00000063887(gene)|ensembl:ENSMUST00000075054(transcript)|ensembl:ENSMUST00000193603(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|rcsb pdb:3B3Q|reactome:R-MMU-6794361|mint:MINT-7989257(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989259(identity) - - - figure legend:sf3b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:v8ZiOUF8s1yNWhimIoIUHCDdiD810090 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:656BFBADA4EFF776|rigid:NIEJ2GcirIeTYtPjBBVM/ixLHAk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14522 uniprotkb:P39688 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547 psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281651|mint:MINT-7989207|imex:IM-14604-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989213(identity) ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N|mint:MINT-7989209(identity) - - - figure legend:f6b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090 intact-crc:B009BFCB2EF6BC9D|rigid:g27vMcj/XgVy6gqCFHXQGDurzEE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-7281394 uniprotkb:O14522 genbank_protein_gi:62243518|intact:MINT-7989394 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nrx2a(display_short)|psi-mi:EBI-7281394(display_long) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281712|mint:MINT-7989351|imex:IM-14604-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:MINT-7989355(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989353(identity) - comment:mint|no-uniprot-update: - comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 - rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:96DBD5A540784BC9 false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6P9K9 uniprotkb:O14522 intact:EBI-7281557|uniprotkb:E9Q466|intact:MINT-7989389|uniprotkb:E9PW93|intact:MINT-4115192|uniprotkb:Q8CCT8|ensembl:ENSMUSP00000129678 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nrx3a_mouse(display_long)|uniprotkb:Nrxn3(gene name)|psi-mi:Nrxn3(display_short)|uniprotkb:Neurexin III-alpha(gene name synonym)|uniprotkb:Neurexin-3-alpha(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281722|mint:MINT-7989361|imex:IM-14604-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006515620.1|refseq:NP_766132.2|refseq:NP_001185516.2|ensembl:ENSMUSG00000066392(gene)|ensembl:ENSMUST00000163134(transcript)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|mint:Q6P9K9|rcsb pdb:3MW4|reactome:R-MMU-6794361|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|mint:MINT-7989363(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989365(identity) - comment:mint - comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:doHQ/O7sneKAIREyTfP+n+U7axQ10090 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:FBED3D7F24FF5FE7|rigid:ebFltlgZrcumU1yDS7zRZytGtUc false cyan fluorescent protein tag:?-?(MINT-7989391) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CS84 uniprotkb:O14522 intact:EBI-399696|uniprotkb:O88722|uniprotkb:Q80Y87|uniprotkb:Q8CHE6|uniprotkb:G3UWZ9|ensembl:ENSMUSP00000124116 intact:EBI-728180|uniprotkb:O43655|uniprotkb:O75664|uniprotkb:Q5W0X9|uniprotkb:Q5W0Y1|uniprotkb:Q9BR24|uniprotkb:Q9BR28|uniprotkb:Q9H0Y8|uniprotkb:Q9NTL1|uniprotkb:Q9NU72|uniprotkb:Q9UBD2|uniprotkb:Q9UJL7|ensembl:ENSP00000362283|uniprotkb:A8E4R6 psi-mi:nrx1a_mouse(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-alpha(gene name synonym)|uniprotkb:Kiaa0578(gene name synonym)|uniprotkb:Neurexin-1-alpha(gene name synonym) psi-mi:ptprt_human(display_long)|uniprotkb:PTPRT(gene name)|psi-mi:PTPRT(display_short)|uniprotkb:KIAA0283(gene name synonym)|uniprotkb:Receptor-type tyrosine-protein phosphatase rho(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lim et al. (2009) pubmed:19816407|imex:IM-14604|mint:MINT-7986473|doi:10.1038/emboj.2009.289 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7281684|mint:MINT-7989334|imex:IM-14604-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064648.3|refseq:NP_796258.2|refseq:XP_006523875.1|refseq:XP_006523874.1|refseq:XP_006523879.1|refseq:NP_001333891.1|ensembl:ENSMUSG00000024109(gene)|ensembl:ENSMUST00000161402(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|rcsb pdb:3BOD|rcsb pdb:3MW2|rcsb pdb:6PNP|rcsb pdb:6PNQ|reactome:R-MMU-6794361|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|mint:MINT-7989336(identity) ensembl:ENSG00000196090(gene)|ensembl:ENST00000373187(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|mint:O14522|rcsb pdb:2OOQ|refseq:NP_008981.4|refseq:NP_573400.3|dip:DIP-33967N|mint:MINT-7989340(identity) - - - comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/07/27 2014/10/16 rogid:/fUMo/ju6izl+U1uBzDw5AaJMU010090 rogid:GKfTiUL+lsxQPu7/ibKdpoUy6rE9606 intact-crc:1865EE4AC09BAED7|rigid:kErjQbTBCFW1d0wgXyYU1HxjrJo false cyan fluorescent protein tag:?-?(MINT-7989346) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot)