#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08567	uniprotkb:P02776	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2565499|imex:IM-13589-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1 and Table 1|comment:plek-3 E is a pseudo-phosphorylated mutated form of plek|delivery method:P08567 recombination|caution:"In the figure 1 GST-plek 3E associated with SDPR (from PKC inhibited platelets) but it is not reported in tha table 1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	intact-crc:FEA071DC5C14F752|rigid:Y0hHGa/w+OfVwfVTAAgKs6mjzto	false	mutation:117-117,113-113,114-114|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P12814	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2565499|imex:IM-13589-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1 and Table 1|comment:plek-3 E is a pseudo-phosphorylated mutated form of plek|delivery method:P08567 recombination|caution:"In the figure 1 GST-plek 3E associated with SDPR (from PKC inhibited platelets) but it is not reported in tha table 1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	intact-crc:FEA071DC5C14F752|rigid:Y0hHGa/w+OfVwfVTAAgKs6mjzto	false	mutation:117-117,113-113,114-114|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:O95810	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-742141|ensembl:ENSP00000305675	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:cavn2_human(display_long)|uniprotkb:CAVIN2(gene name)|psi-mi:CAVIN2(display_short)|uniprotkb:Cavin-2(gene name synonym)|uniprotkb:PS-p68(gene name synonym)|uniprotkb:Phosphatidylserine-binding protein(gene name synonym)|uniprotkb:SDPR(gene name synonym)|uniprotkb:Serum deprivation-response protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2565967|imex:IM-13589-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_004648.1|ensembl:ENSG00000168497(gene)|ensembl:ENST00000304141(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0045121"(membrane raft)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR026752|interpro:IPR033298|mint:O95810|dip:DIP-56943N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:sarAwuO9gdc0htbb0NTV4zMVnpw9606	intact-crc:A3A733EB60C31B21|rigid:YKcWSf8JssyEnTWZL4JiOPpLuDs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P02776	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2565967|imex:IM-13589-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	intact-crc:A3A733EB60C31B21|rigid:YKcWSf8JssyEnTWZL4JiOPpLuDs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P07996	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2565967|imex:IM-13589-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	intact-crc:A3A733EB60C31B21|rigid:YKcWSf8JssyEnTWZL4JiOPpLuDs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:O95810	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-742141|ensembl:ENSP00000305675	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:cavn2_human(display_long)|uniprotkb:CAVIN2(gene name)|psi-mi:CAVIN2(display_short)|uniprotkb:Cavin-2(gene name synonym)|uniprotkb:PS-p68(gene name synonym)|uniprotkb:Phosphatidylserine-binding protein(gene name synonym)|uniprotkb:SDPR(gene name synonym)|uniprotkb:Serum deprivation-response protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2565717|imex:IM-13589-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_004648.1|ensembl:ENSG00000168497(gene)|ensembl:ENST00000304141(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0045121"(membrane raft)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR026752|interpro:IPR033298|mint:O95810|dip:DIP-56943N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:sarAwuO9gdc0htbb0NTV4zMVnpw9606	intact-crc:50F3C89C41E94F15|rigid:hKd72DFP2syTCyuYAa5wLbkc98g	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P26038	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-528768|ensembl:ENSP00000353408	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567235|imex:IM-13589-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:plek-3 E is a pseudo-phosphorylated mutated form of plek|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606	intact-crc:57645AF75D67F695|rigid:x8Qn/19Rq1G31USFqlGKZsSSobE	false	mutation:113-113,114-114,117-117|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:O95810	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-742141|ensembl:ENSP00000305675	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:cavn2_human(display_long)|uniprotkb:CAVIN2(gene name)|psi-mi:CAVIN2(display_short)|uniprotkb:Cavin-2(gene name synonym)|uniprotkb:PS-p68(gene name synonym)|uniprotkb:Phosphatidylserine-binding protein(gene name synonym)|uniprotkb:SDPR(gene name synonym)|uniprotkb:Serum deprivation-response protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567235|imex:IM-13589-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_004648.1|ensembl:ENSG00000168497(gene)|ensembl:ENST00000304141(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0045121"(membrane raft)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR026752|interpro:IPR033298|mint:O95810|dip:DIP-56943N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:plek-3 E is a pseudo-phosphorylated mutated form of plek|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:sarAwuO9gdc0htbb0NTV4zMVnpw9606	intact-crc:57645AF75D67F695|rigid:x8Qn/19Rq1G31USFqlGKZsSSobE	false	mutation:113-113,114-114,117-117|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P00488	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2565863|uniprotkb:Q59HA7|uniprotkb:Q8N6X2|uniprotkb:Q96P24|uniprotkb:Q9BX29|ensembl:ENSP00000264870	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:f13a_human(display_long)|uniprotkb:F13A1(gene name)|psi-mi:F13A1(display_short)|uniprotkb:F13A(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase A chain(gene name synonym)|uniprotkb:Transglutaminase A chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567235|imex:IM-13589-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_000120.2|ensembl:ENSG00000124491(gene)|ensembl:ENST00000264870(transcript)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR034810|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:P00488|rcsb pdb:1EVU|rcsb pdb:1EX0|rcsb pdb:1F13|rcsb pdb:1FIE|rcsb pdb:1GGT|rcsb pdb:1GGU|rcsb pdb:1GGY|rcsb pdb:1QRK|rcsb pdb:4KTY|rcsb pdb:5MHL|rcsb pdb:5MHM|rcsb pdb:5MHN|rcsb pdb:5MHO|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-6785807|dip:DIP-377N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:plek-3 E is a pseudo-phosphorylated mutated form of plek|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:34D4YYpfrOOyyBb40huqk78DnOs9606	intact-crc:57645AF75D67F695|rigid:x8Qn/19Rq1G31USFqlGKZsSSobE	false	mutation:113-113,114-114,117-117|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P07996	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567235|imex:IM-13589-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:plek-3 E is a pseudo-phosphorylated mutated form of plek|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	intact-crc:57645AF75D67F695|rigid:x8Qn/19Rq1G31USFqlGKZsSSobE	false	mutation:113-113,114-114,117-117|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P51659	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-358398|ensembl:ENSP00000424940|uniprotkb:B4DNV1|uniprotkb:B4DVS5|uniprotkb:E9PB82|uniprotkb:F5HE57	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:dhb4_human(display_long)|uniprotkb:HSD17B4(gene name)|psi-mi:HSD17B4(display_short)|uniprotkb:EDH17B4(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:SDR8C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 8C member 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567235|imex:IM-13589-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_000405.1|refseq:NP_001186220.1|refseq:NP_001186221.1|refseq:NP_001278956.1|refseq:NP_001278957.1|ensembl:ENSG00000133835(gene)|ensembl:ENST00000510025(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|rcsb pdb:1IKT|rcsb pdb:1S9C|rcsb pdb:1ZBQ|rcsb pdb:6Z1W|rcsb pdb:6Z1X|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|reactome:R-HSA-9033500	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:plek-3 E is a pseudo-phosphorylated mutated form of plek|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:i3A0dh9gAO2vfrCYXvo2U6+PwJQ9606	intact-crc:57645AF75D67F695|rigid:x8Qn/19Rq1G31USFqlGKZsSSobE	false	mutation:113-113,114-114,117-117|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P35241	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2514878|ensembl:ENSP00000496503|uniprotkb:Q86Y61|uniprotkb:A7YIK0|uniprotkb:A7YIK3|uniprotkb:A7YIJ8|uniprotkb:B7Z9U6|uniprotkb:F5H1A7	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:radi_human(display_long)|uniprotkb:RDX(gene name)|psi-mi:RDX(display_short)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567235|imex:IM-13589-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	ensembl:ENSG00000137710(gene)|ensembl:ENST00000645495(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:1903392"(negative regulation of adherens junction organization)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35241|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_002897.1|refseq:NP_001247423.1|refseq:NP_001247424.1|refseq:NP_001247425.1|refseq:NP_001247421.1|refseq:NP_001247422.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:plek-3 E is a pseudo-phosphorylated mutated form of plek|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:75lzbINdL0deHtiWY7IwioSh5749606	intact-crc:57645AF75D67F695|rigid:x8Qn/19Rq1G31USFqlGKZsSSobE	false	mutation:113-113,114-114,117-117|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P02776	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567291|imex:IM-13589-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from pf4 (P02776) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets (msn, rdx, f13a1) or in PKC-inhibited platelets (SDPR, tsp1)."|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	intact-crc:0585D756CFA4FD58|rigid:A1wBKCfxmXBkKIyi6gCWtgdedM4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P00488	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2565863|uniprotkb:Q59HA7|uniprotkb:Q8N6X2|uniprotkb:Q96P24|uniprotkb:Q9BX29|ensembl:ENSP00000264870	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:f13a_human(display_long)|uniprotkb:F13A1(gene name)|psi-mi:F13A1(display_short)|uniprotkb:F13A(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase A chain(gene name synonym)|uniprotkb:Transglutaminase A chain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567291|imex:IM-13589-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_000120.2|ensembl:ENSG00000124491(gene)|ensembl:ENST00000264870(transcript)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR034810|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:P00488|rcsb pdb:1EVU|rcsb pdb:1EX0|rcsb pdb:1F13|rcsb pdb:1FIE|rcsb pdb:1GGT|rcsb pdb:1GGU|rcsb pdb:1GGY|rcsb pdb:1QRK|rcsb pdb:4KTY|rcsb pdb:5MHL|rcsb pdb:5MHM|rcsb pdb:5MHN|rcsb pdb:5MHO|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-6785807|dip:DIP-377N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from pf4 (P02776) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets (msn, rdx, f13a1) or in PKC-inhibited platelets (SDPR, tsp1)."|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:34D4YYpfrOOyyBb40huqk78DnOs9606	intact-crc:0585D756CFA4FD58|rigid:A1wBKCfxmXBkKIyi6gCWtgdedM4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P35241	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2514878|ensembl:ENSP00000496503|uniprotkb:Q86Y61|uniprotkb:A7YIK0|uniprotkb:A7YIK3|uniprotkb:A7YIJ8|uniprotkb:B7Z9U6|uniprotkb:F5H1A7	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:radi_human(display_long)|uniprotkb:RDX(gene name)|psi-mi:RDX(display_short)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567291|imex:IM-13589-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	ensembl:ENSG00000137710(gene)|ensembl:ENST00000645495(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:1903392"(negative regulation of adherens junction organization)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35241|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_002897.1|refseq:NP_001247423.1|refseq:NP_001247424.1|refseq:NP_001247425.1|refseq:NP_001247421.1|refseq:NP_001247422.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from pf4 (P02776) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets (msn, rdx, f13a1) or in PKC-inhibited platelets (SDPR, tsp1)."|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:75lzbINdL0deHtiWY7IwioSh5749606	intact-crc:0585D756CFA4FD58|rigid:A1wBKCfxmXBkKIyi6gCWtgdedM4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P26038	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-528768|ensembl:ENSP00000353408	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short)	psi-mi:"MI:0096"(pull down)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567291|imex:IM-13589-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from pf4 (P02776) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets (msn, rdx, f13a1) or in PKC-inhibited platelets (SDPR, tsp1)."|delivery method:P08567 recombination|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606	intact-crc:0585D756CFA4FD58|rigid:A1wBKCfxmXBkKIyi6gCWtgdedM4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:O95810	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-742141|ensembl:ENSP00000305675	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:cavn2_human(display_long)|uniprotkb:CAVIN2(gene name)|psi-mi:CAVIN2(display_short)|uniprotkb:Cavin-2(gene name synonym)|uniprotkb:PS-p68(gene name synonym)|uniprotkb:Phosphatidylserine-binding protein(gene name synonym)|uniprotkb:SDPR(gene name synonym)|uniprotkb:Serum deprivation-response protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567322|imex:IM-13589-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_004648.1|ensembl:ENSG00000168497(gene)|ensembl:ENST00000304141(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0045121"(membrane raft)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR026752|interpro:IPR033298|mint:O95810|dip:DIP-56943N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from SDPR (O95810) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:sarAwuO9gdc0htbb0NTV4zMVnpw9606	intact-crc:428A521B6EAD9B60|rigid:AMo1JjYnYTxMe5OOEfomoIyyEsQ	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P26038	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-528768|ensembl:ENSP00000353408	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567322|imex:IM-13589-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from SDPR (O95810) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606	intact-crc:428A521B6EAD9B60|rigid:AMo1JjYnYTxMe5OOEfomoIyyEsQ	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P02776	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567322|imex:IM-13589-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from SDPR (O95810) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	intact-crc:428A521B6EAD9B60|rigid:AMo1JjYnYTxMe5OOEfomoIyyEsQ	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P07996	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567322|imex:IM-13589-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from SDPR (O95810) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	intact-crc:428A521B6EAD9B60|rigid:AMo1JjYnYTxMe5OOEfomoIyyEsQ	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P51659	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-358398|ensembl:ENSP00000424940|uniprotkb:B4DNV1|uniprotkb:B4DVS5|uniprotkb:E9PB82|uniprotkb:F5HE57	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:dhb4_human(display_long)|uniprotkb:HSD17B4(gene name)|psi-mi:HSD17B4(display_short)|uniprotkb:EDH17B4(gene name synonym)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)|uniprotkb:SDR8C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 8C member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567322|imex:IM-13589-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_000405.1|refseq:NP_001186220.1|refseq:NP_001186221.1|refseq:NP_001278956.1|refseq:NP_001278957.1|ensembl:ENSG00000133835(gene)|ensembl:ENST00000510025(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0060009"(Sertoli cell development)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR020904|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|rcsb pdb:1IKT|rcsb pdb:1S9C|rcsb pdb:1ZBQ|rcsb pdb:6Z1W|rcsb pdb:6Z1X|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|reactome:R-HSA-9033500	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from SDPR (O95810) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:i3A0dh9gAO2vfrCYXvo2U6+PwJQ9606	intact-crc:428A521B6EAD9B60|rigid:AMo1JjYnYTxMe5OOEfomoIyyEsQ	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P12814	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567322|imex:IM-13589-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from SDPR (O95810) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	intact-crc:428A521B6EAD9B60|rigid:AMo1JjYnYTxMe5OOEfomoIyyEsQ	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P08567	uniprotkb:P35241	intact:EBI-2565501|uniprotkb:B2R9E8|uniprotkb:Q53SU8|uniprotkb:Q6FGM8|uniprotkb:Q6FGQ1|uniprotkb:Q8WV81|ensembl:ENSP00000234313	intact:EBI-2514878|ensembl:ENSP00000496503|uniprotkb:Q86Y61|uniprotkb:A7YIK0|uniprotkb:A7YIK3|uniprotkb:A7YIJ8|uniprotkb:B7Z9U6|uniprotkb:F5H1A7	psi-mi:plek_human(display_long)|uniprotkb:PLEK(gene name)|psi-mi:PLEK(display_short)|uniprotkb:P47(gene name synonym)|uniprotkb:Platelet 47 kDa protein(gene name synonym)	psi-mi:radi_human(display_long)|uniprotkb:RDX(gene name)|psi-mi:RDX(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baig et al. (2009)	imex:IM-13589|pubmed:19722192	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2567322|imex:IM-13589-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002655.2|ensembl:ENSG00000115956(gene)|ensembl:ENST00000234313(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002576"(platelet degranulation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0010925"(positive regulation of inositol-polyphosphate 5-phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030845"(phospholipase C-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0060305"(regulation of cell diameter)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070560"(protein secretion by platelet)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037371|rcsb pdb:1PLS|rcsb pdb:1W4M|rcsb pdb:1X05|rcsb pdb:1XX0|rcsb pdb:1ZM0|rcsb pdb:2CSO|rcsb pdb:2I5C|rcsb pdb:2I5F|reactome:R-HSA-114608|go:"GO:0007229"(integrin-mediated signaling pathway)	ensembl:ENSG00000137710(gene)|ensembl:ENST00000645495(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:1903392"(negative regulation of adherens junction organization)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35241|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_002897.1|refseq:NP_001247423.1|refseq:NP_001247424.1|refseq:NP_001247425.1|refseq:NP_001247421.1|refseq:NP_001247422.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 1|comment:"Apart from SDPR (O95810) which associates with pleck in either PKC-inhibited (Ro 31-8220) and PKC-activated (PMA/calA) platelets, all interactors associates with pleck in PKC-activated platelets."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-platelet)|taxid:9606(Homo sapiens platelet, thrombocytes)	-	2010/02/01	2014/10/16	rogid:WZgHrbqX/+j602xfp5JvX8truTg9606	rogid:75lzbINdL0deHtiWY7IwioSh5749606	intact-crc:428A521B6EAD9B60|rigid:AMo1JjYnYTxMe5OOEfomoIyyEsQ	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)