#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O43678 uniprotkb:O00483 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1049381|uniprotkb:Q6FHN5|uniprotkb:A4D109|ensembl:ENSP00000339720 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua4_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase MLRQ subunit(gene name synonym)|uniprotkb:Complex I-MLRQ(gene name synonym)|uniprotkb:NDUFA4(gene name)|psi-mi:NDUFA4(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002480.1|ensembl:ENSG00000189043(gene)|ensembl:ENST00000339600(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|interpro:IPR010530(B12D)|mint:O00483|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:TnrYlkH8abl42/yGsvfc8Bh6Mu09606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q16718 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-746417|uniprotkb:Q6IRX7|uniprotkb:Q5H9R2|uniprotkb:B2RD98|ensembl:ENSP00000347988 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua5_human(display_long)|uniprotkb:Complex I subunit B13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-B subunit(gene name synonym)|uniprotkb:Complex I-13kD-B(gene name synonym)|uniprotkb:NDUFA5(gene name)|psi-mi:NDUFA5(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004991.1|refseq:NP_001269348.1|refseq:NP_001269350.1|refseq:NP_001269351.1|ensembl:ENSG00000128609(gene)|ensembl:ENST00000355749(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR006806(ETC complex I subunit)|mint:Q16718|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408|refseq:NP_001269349.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:t042+V0dLA6z/X1MQdgkt7ya7qs9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P56556 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-714658|uniprotkb:O43675|uniprotkb:Q6IC39|uniprotkb:B2RE54|uniprotkb:Q6FGW0|uniprotkb:Q6IBT8|ensembl:ENSP00000418842|ensembl:ENSP00000475402|ensembl:ENSP00000486781|ensembl:ENSP00000487431|ensembl:ENSP00000487462 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua6_human(display_long)|uniprotkb:LYRM6(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B14 subunit(gene name synonym)|uniprotkb:Complex I-B14(gene name synonym)|uniprotkb:LYR motif-containing protein 6(gene name synonym)|uniprotkb:NDUFA6(gene name)|psi-mi:NDUFA6(display_short)|uniprotkb:NADHB14(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002481.2|ensembl:ENSG00000184983(gene)|ensembl:ENSG00000272765(gene)|ensembl:ENSG00000273397(gene)|ensembl:ENSG00000277365(gene)|ensembl:ENSG00000281013(gene)|ensembl:ENST00000498737(transcript)|ensembl:ENST00000605916(transcript)|ensembl:ENST00000628740(transcript)|ensembl:ENST00000630201(transcript)|ensembl:ENST00000630971(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR016488("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6")|mint:P56556|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:rI1B6Ym+ps0tKfJIClYRtej8KcU9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O95182 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-721471|ensembl:ENSP00000301457|ensembl:ENSP00000470962 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua7_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B14.5a(gene name synonym)|uniprotkb:Complex I-B14.5a(gene name synonym)|uniprotkb:NDUFA7(gene name)|psi-mi:NDUFA7(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004992.2|ensembl:ENSG00000267855(gene)|ensembl:ENST00000301457(transcript)|ensembl:ENST00000593729(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032543"(mitochondrial translation)|interpro:IPR009947("NADH:ubiquinone oxidoreductase subunit B14.5a")|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:FUdu0Oxjx6fLyDbe6WDbyfwKZW89606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P51970 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q16795 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1045087|uniprotkb:Q14076|uniprotkb:Q2NKX0|ensembl:ENSP00000266544 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua9_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 39 kDa subunit(gene name synonym)|uniprotkb:Complex I-39kD(gene name synonym)|uniprotkb:NDUFA9(gene name)|psi-mi:NDUFA9(display_short)|uniprotkb:NDUFS2L(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004993.1|ensembl:ENSG00000139180(gene)|ensembl:ENST00000266544(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009749"(response to glucose)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1901006"(ubiquinone-6 biosynthetic process)|interpro:IPR001509(NAD-dependent epimerase/dehydratase)|interpro:IPR036291|mint:Q16795|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|dip:DIP-38526N - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:eM2zUsbdjMEILIcUedVOyEMwAzU9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O95299 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246361|uniprotkb:Q8WXC9|ensembl:ENSP00000252711|ensembl:ENSP00000503956|ensembl:ENSP00000504765 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduaa_human(display_long)|uniprotkb:NDUFA10(gene name)|psi-mi:NDUFA10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 42 kDa subunit(gene name synonym)|uniprotkb:Complex I-42kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004535.1|ensembl:ENSG00000130414(gene)|ensembl:ENST00000252711(transcript)|ensembl:ENST00000676929(transcript)|ensembl:ENST00000678158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR015828(NADH-ubiquinone oxidoreductase, 42 kDa subunit)|interpro:IPR027417|interpro:IPR031314|mint:O95299|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:8jwJPJ0rD9H7A4AzxPd186tpXYs9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q86Y39 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246415|uniprotkb:Q6ZS66|uniprotkb:C9JT23|ensembl:ENSP00000311740 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduab_human(display_long)|uniprotkb:NDUFA11(gene name)|psi-mi:NDUFA11(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B14.7(gene name synonym)|uniprotkb:Complex I-B14.7(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_783313.1|refseq:NP_001180304.1|ensembl:ENSG00000174886(gene)|ensembl:ENST00000308961(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039205|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:w6WASokPDfLWJ57ntErW7LgdpBA9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q9UI09 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246332|uniprotkb:Q9BRV6|uniprotkb:Q53XX0|uniprotkb:F8VQS7|ensembl:ENSP00000330737 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduac_human(display_long)|uniprotkb:NDUFA12(gene name)|psi-mi:NDUFA12(display_short)|uniprotkb:DAP13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B17.2(gene name synonym)|uniprotkb:Complex I-B17.2(gene name synonym)|uniprotkb:13 kDa differentiation-associated protein(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_061326.1|refseq:NP_001245267.1|ensembl:ENSG00000184752(gene)|ensembl:ENST00000327772(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:bQJVtT1ycebwYktMsNrejTZmG4k9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q9P0J0 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-372742|uniprotkb:Q6PKI0|uniprotkb:Q9H2L3|uniprotkb:Q9Y327|uniprotkb:B4DF76|uniprotkb:K7EK58|ensembl:ENSP00000423673 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduad_human(display_long)|uniprotkb:NDUFA13(gene name)|psi-mi:NDUFA13(display_short)|uniprotkb:CGI-39(orf name)|uniprotkb:CDA016(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase B16.6 subunit(gene name synonym)|uniprotkb:Complex I-B16.6(gene name synonym)|uniprotkb:Gene associated with retinoic and interferon-induced mortality 19 protein(gene name synonym)|uniprotkb:Cell death regulatory protein GRIM-19(gene name synonym)|uniprotkb:GRIM19(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_057049.5|go:"GO:0005524"(ATP binding)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR009346(GRIM-19)|mint:Q9P0J0|rcsb pdb:5XTB|rcsb pdb:5XTC|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|ensembl:ENSG00000186010(gene)|ensembl:ENST00000507754(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|dip:DIP-31180N - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:X5AsKHIxU5kpNVjY37UbZXG/Kns9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O43676 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-718365|uniprotkb:Q6IB80|ensembl:ENSP00000237889|ensembl:ENSP00000401834|ensembl:ENSP00000407336|ensembl:ENSP00000410600|ensembl:ENSP00000507925|ensembl:ENSP00000508132|ensembl:ENSP00000508208 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub3_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase B12 subunit(gene name synonym)|uniprotkb:Complex I-B12(gene name synonym)|uniprotkb:NDUFB3(gene name)|psi-mi:NDUFB3(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002482.1|refseq:XP_011509532.1|refseq:XP_016859675.1|refseq:NP_001244031.1|ensembl:ENSP00000237889|ensembl:ENSP00000410600|ensembl:ENSP00000401834|ensembl:ENSP00000407336|ensembl:ENSP00000507925|ensembl:ENSP00000508132|ensembl:ENSP00000508208|ensembl:ENSG00000119013(gene)|ensembl:ENST00000237889(transcript)|ensembl:ENST00000433898(transcript)|ensembl:ENST00000450023(transcript)|ensembl:ENST00000454214(transcript)|ensembl:ENST00000682325(transcript)|ensembl:ENST00000684175(transcript)|ensembl:ENST00000684420(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR012576(NADH-ubiquinone oxidoreductase B12 subunit)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:APgw3aIZyyqiPCXMFJ9dUYPQhVE9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O43674 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246293|uniprotkb:Q561V6|ensembl:ENSP00000259037 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub5_human(display_long)|uniprotkb:NDUFB5(gene name)|psi-mi:NDUFB5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase SGDH subunit(gene name synonym)|uniprotkb:Complex I-SGDH(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001186886.1|refseq:NP_001186887.1|refseq:NP_002483.1|ensembl:ENSG00000136521(gene)|ensembl:ENST00000259037(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019173|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:1UrbNq39EsuKHJ2M7tRd8ZmB6uk9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P17568 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246238|uniprotkb:Q9UI16|uniprotkb:Q6ICN9|ensembl:ENSP00000215565 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub7_human(display_long)|uniprotkb:NDUFB7(gene name)|psi-mi:NDUFB7(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B18 subunit(gene name synonym)|uniprotkb:Complex I-B18(gene name synonym)|uniprotkb:Cell adhesion protein SQM1(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004137.2|ensembl:ENSG00000099795(gene)|ensembl:ENST00000215565(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008698(NADH-ubiquinone oxidoreductase B18 subunit)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:9ghtJGrnow8MT1PKXEV2aYuzk0w9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O95169 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-716238|uniprotkb:Q5W144|uniprotkb:Q9UG53|uniprotkb:Q9UJR4|uniprotkb:Q9UQF3|uniprotkb:A8K0L4|intact:EBI-11021395|uniprotkb:Q5W143|uniprotkb:Q5W145|intact:EBI-28971189|ensembl:ENSP00000299166 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub8_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase ASHI subunit(gene name synonym)|uniprotkb:Complex I-ASHI(gene name synonym)|uniprotkb:NDUFB8(gene name)|psi-mi:NDUFB8(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 ensembl:ENSP00000299166|ensembl:ENST00000370320|ensembl:ENSP00000359344|ensembl:ENST00000370322|ensembl:ENSP00000359346|refseq:NP_004995.1|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008699(NADH-ubiquinone oxidoreductase ASHI subunit)|interpro:IPR016551("NADH dehydrogenase [ubiquinone] (complex I), beta subcomplex, subunit 8")|rcsb pdb:5XTC|rcsb pdb:5XTD|ensembl:ENSG00000166136(gene)|ensembl:ENST00000299166(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|refseq:NP_001271296.1|refseq:NP_001271297.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:iHF93OOQynl/ZBrUOOp9sAbDZkw9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q9Y6M9 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-713654|uniprotkb:Q9UQE8|uniprotkb:B2R8M6|ensembl:ENSP00000276689|ensembl:ENSP00000504235 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub9_human(display_long)|uniprotkb:LYRM3(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B22 subunit(gene name synonym)|uniprotkb:Complex I-B22(gene name synonym)|uniprotkb:LYR motif-containing protein 3(gene name synonym)|uniprotkb:NDUFB9(gene name)|psi-mi:NDUFB9(display_short)|uniprotkb:UQOR22(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 rcsb pdb:5XTH|rcsb pdb:5XTD|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000147684(gene)|ensembl:ENST00000276689(transcript)|ensembl:ENST00000677021(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR033034|mint:Q9Y6M9|rcsb pdb:5XTC|refseq:NP_001298097.1|refseq:NP_004996.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:sNQcYhIFMHZA5T6MeeiwAeAJ5Gs9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O96000 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q9NX14 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246182|uniprotkb:Q5JRR3|uniprotkb:Q5JRR4|uniprotkb:Q6IAB6|uniprotkb:Q8WZ96|uniprotkb:Q9BXX9|ensembl:ENSP00000367042 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndubb_human(display_long)|uniprotkb:NDUFB11(gene name)|psi-mi:NDUFB11(display_short)|uniprotkb:UNQ111/PRO1064(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase ESSS subunit(gene name synonym)|uniprotkb:Complex I-ESSS(gene name synonym)|uniprotkb:Neuronal protein 17.3(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001129470.1|refseq:NP_061929.2|ensembl:ENSG00000147123(gene)|ensembl:ENST00000377811(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019329|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:CAloB+PJ0fcnLukpvgNGgTFJ0zs9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O95298 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246172|uniprotkb:Q9UBJ9|uniprotkb:Q6FIH8|uniprotkb:Q549M5|uniprotkb:E9PNU8|uniprotkb:E9PRB2|ensembl:ENSP00000281031 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduc2_human(display_long)|uniprotkb:NDUFC2(gene name)|psi-mi:NDUFC2(display_short)|uniprotkb:HLC1(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B14.5b(gene name synonym)|uniprotkb:Complex I-B14.5b(gene name synonym)|uniprotkb:Human lung cancer oncogene 1 protein(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004540.1|refseq:NP_001190983.1|refseq:NP_001190984.1|ensembl:ENSG00000151366(gene)|ensembl:ENST00000281031(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005886"(plasma membrane)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035577"(azurophil granule membrane)|interpro:IPR009423(NADH-ubiquinone oxidoreductase subunit b14.5b)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6798695|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:IILkKsJHyRjCMZJ6z//WjdRXQUQ9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P28331 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O75306 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O75489 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 - - crc64:C058D62779BEF17B figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O43181 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246139|uniprotkb:Q9BS69|ensembl:ENSP00000296684 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus4_human(display_long)|uniprotkb:NDUFS4(gene name)|psi-mi:NDUFS4(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 18 kDa subunit(gene name synonym)|uniprotkb:Complex I-18 kDa(gene name synonym)|uniprotkb:Complex I-AQDQ(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002486.1|ensembl:ENSG00000164258(gene)|ensembl:ENST00000296684(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007420"(brain development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR006885(ETC complex I subunit conserved region)|interpro:IPR038532|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:T/NnuQagNs7EnceU9XKo4eUdy2o9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O43920 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246091|ensembl:ENSP00000362058|ensembl:ENSP00000362060 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus5_human(display_long)|uniprotkb:NDUFS5(gene name)|psi-mi:NDUFS5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 15 kDa subunit(gene name synonym)|uniprotkb:Complex I-15 kDa(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001171908.1|refseq:NP_004543.1|ensembl:ENSG00000168653(gene)|ensembl:ENST00000372967(transcript)|ensembl:ENST00000372969(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019342|mint:O43920|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:q74OuEXKdyCuxrUujwHeZjkW2gY9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O75380 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-719854|ensembl:ENSP00000274137 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus6_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-A subunit(gene name synonym)|uniprotkb:Complex I-13kD-A(gene name synonym)|uniprotkb:NDUFS6(gene name)|psi-mi:NDUFS6(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004544.1|ensembl:ENSG00000145494(gene)|ensembl:ENST00000274137(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|interpro:IPR016668("NADH dehydrogenase [ubiquinone] (complex I), iron-sulphur protein 6, mitochondria")|interpro:IPR019401|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:IfpFyQjgJW6a8wA2pNw14stMUL49606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O75251 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-719652|uniprotkb:Q2T9H7|uniprotkb:Q9BV17|ensembl:ENSP00000233627|uniprotkb:B3KRI2 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus7_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 20 kDa subunit(gene name synonym)|uniprotkb:Complex I-20kD(gene name synonym)|uniprotkb:PSST subunit(gene name synonym)|uniprotkb:NDUFS7(gene name)|psi-mi:NDUFS7(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_077718.3|ensembl:ENSG00000115286(gene)|ensembl:ENST00000233627(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048038"(quinone binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097060"(synaptic membrane)|interpro:IPR006137(NADH ubiquinone oxidoreductase, 20 kDa subunit)|interpro:IPR006138("NADH dehydrogenase (ubiquinone), 20 kDa subunit")|mint:O75251|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:DtNXT30ApcGKwTJSdNNwHd/q3+09606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O00217 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246309|uniprotkb:Q0VDA8|uniprotkb:B2RB86|ensembl:ENSP00000315774 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus8_human(display_long)|uniprotkb:NDUFS8(gene name)|psi-mi:NDUFS8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 23 kDa subunit(gene name synonym)|uniprotkb:Complex I-23kD(gene name synonym)|uniprotkb:TYKY subunit(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002487.1|refseq:XP_011543355.1|refseq:XP_005274070.1|refseq:XP_005274071.1|ensembl:ENSG00000110717(gene)|ensembl:ENST00000313468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR010226(NADH-quinone oxidoreductase, chain I)|interpro:IPR017896|interpro:IPR017900|mint:O00217|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:VzxtzGTNMccCfBDeDy9LKDN5V289606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P49821 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-748312|uniprotkb:Q6IBR3|uniprotkb:O60924|uniprotkb:O60940|uniprotkb:Q16104|uniprotkb:Q96BF8|uniprotkb:Q96HS7|ensembl:ENSP00000322450|ensembl:ENSP00000497587 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduv1_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 51 kDa subunit(gene name synonym)|uniprotkb:Complex I-51kD(gene name synonym)|uniprotkb:NADH dehydrogenase flavoprotein 1(gene name synonym)|uniprotkb:NDUFV1(gene name)|psi-mi:NDUFV1(display_short)|uniprotkb:UQOR1(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001159574.1|refseq:NP_009034.2|ensembl:ENSG00000167792(gene)|ensembl:ENST00000322776(transcript)|ensembl:ENST00000647561(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010181"(FMN binding)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001949(NADH-ubiquinone oxidoreductase, 51 kDa subunit, conserved site)|interpro:IPR011537(NADH-ubiquinone oxidoreductase, F subunit)|interpro:IPR011538(NADH-ubiquinone oxidoreductase, 51 kDa subunit)|interpro:IPR019554|interpro:IPR019575|interpro:IPR037207|interpro:IPR037225|mint:P49821|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:0pEd6isDBEamZQJ5QNo5yJ7rKu89606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P19404 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-713665|uniprotkb:Q9BV41|ensembl:ENSP00000327268 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduv2_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 24 kDa subunit(gene name synonym)|uniprotkb:NDUFV2(gene name)|psi-mi:NDUFV2(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 ensembl:ENSG00000178127(gene)|ensembl:ENST00000318388(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002023("NADH dehydrogenase (ubiquinone), 24 kDa subunit")|interpro:IPR036249|interpro:IPR041921|interpro:IPR042128|mint:P19404|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|refseq:NP_066552.2 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:5cG/vsBAIJGKAkWlM0S/rmqJqGM9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P56181 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-721902|uniprotkb:Q6FGD3|uniprotkb:Q9HCR5|uniprotkb:A8K0M1|uniprotkb:Q8WU60|uniprotkb:J3KNX7|ensembl:ENSP00000342895 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduv3_human(display_long)|uniprotkb:Complex I-9kD(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-4(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 9 kDa subunit(gene name synonym)|uniprotkb:NDUFV3(gene name)|psi-mi:NDUFV3(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001001503.1|refseq:NP_066553.3|ensembl:ENSG00000160194(gene)|ensembl:ENST00000340344(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR026193|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:YW1NUj6P01jeBW0dhRhVQaqg7qY9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P03886 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246156|uniprotkb:Q37523|uniprotkb:C0JKH6|ensembl:ENSP00000354687 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nu1m_human(display_long)|uniprotkb:MT-ND1(gene name)|psi-mi:MT-ND1(display_short)|uniprotkb:MTND1(gene name synonym)|uniprotkb:NADH1(gene name synonym)|uniprotkb:ND1(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 1(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:YP_003024026.1|ensembl:ENSG00000198888(gene)|ensembl:ENST00000361390(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|interpro:IPR001694(Respiratory-chain NADH dehydrogenase, subunit 1)|interpro:IPR018086|mint:P03886|rcsb pdb:5XTC|rcsb pdb:5XTD|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:AZoXs+VEdQPt/9D2lr+qBuwsZfA9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P03905 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246274|uniprotkb:Q6RL39|uniprotkb:Q6RQN9|uniprotkb:Q8HNR8|ensembl:ENSP00000354961 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nu4m_human(display_long)|uniprotkb:MT-ND4(gene name)|psi-mi:MT-ND4(display_short)|uniprotkb:MTND4(gene name synonym)|uniprotkb:NADH4(gene name synonym)|uniprotkb:ND4(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 4(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606612|imex:IM-20431-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:YP_003024035.1|ensembl:ENSG00000198886(gene)|ensembl:ENST00000361381(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007568"(aging)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0021549"(cerebellum development)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035094"(response to nicotine)|go:"GO:0045471"(response to ethanol)|go:"GO:0048039"(ubiquinone binding)|interpro:IPR000260(NADH-ubiquinone oxidoreductase chain 4, N-terminal)|interpro:IPR001750("NADH/Ubiquinone/plastoquinone (complex I)")|interpro:IPR003918(NADH-ubiquinone oxidoreductase, chain 4)|interpro:IPR010227(Proton-translocating NADH-quinone oxidoreductase, chain M)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 which match 278, 9 and 7 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:O+b63kRTlmPDBdo6Oe90fRomfeY9606 intact-crc:62A373690E6CEC90|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P21912 uniprotkb:P31040 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606649|imex:IM-20431-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 2 out of the 4 OXPHOS complexe II subunits|comment:The GI number 4759080 does not match any UniProtKB ID. The appropriate UniProtKB ID is P31040 and matches 11 different GI numbers.|comment:"Pearson's correlations between each of these subunits were used to empirically determine a cut-off value of r=0.7, above which profiles retrieved by PCP were considered for further analysis. A protein identified by PCP was considered as a candidate when it had a Pearson's correlation factor of r=0.7 in each BN gel for the template pattern (p<0.0001) and if it had a reported mitochondrial localization or predicted to be mitochondrial by at least two out of five mitochondrial prediction algorithms"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 intact-crc:870E59604D3F59CD|rigid:4mTOLIFFsHkNnDKzk5xJysN8/Qk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:P22695 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-1051424|uniprotkb:Q9BQ05|uniprotkb:B3KSN4|ensembl:ENSP00000268379 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:qcr2_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 2(gene name synonym)|uniprotkb:Core protein II(gene name synonym)|uniprotkb:Complex III subunit 2(gene name synonym)|uniprotkb:UQCRC2(gene name)|psi-mi:UQCRC2(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606656|imex:IM-20431-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 refseq:NP_003357.2|ensembl:ENSG00000140740(gene)|ensembl:ENST00000268379(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006508"(proteolysis)|go:"GO:0009060"(aerobic respiration)|go:"GO:0042493"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P22695|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any uniprot ID. \n The appropriate uniprot ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:++DmwaVpqzRyxFl7mh62L4ku4P09606 intact-crc:50F79D2CEF0F8000|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:P14927 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-743128|ensembl:ENSP00000287022|uniprotkb:Q6FGD1|uniprotkb:E5RJU0 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:qcr7_human(display_long)|uniprotkb:Ubiquinol-cytochrome c reductase complex 14 kDa protein(gene name synonym)|uniprotkb:Complex III subunit 7(gene name synonym)|uniprotkb:Complex III subunit VII(gene name synonym)|uniprotkb:QP-C(gene name synonym)|uniprotkb:UQCRB(gene name)|psi-mi:UQCRB(display_short)|uniprotkb:UQBP(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606656|imex:IM-20431-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 ensembl:ENSG00000156467(gene)|ensembl:ENST00000287022(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0009060"(aerobic respiration)|interpro:IPR003197(Cytochrome bd ubiquinol oxidase, 14 kDa subunit)|interpro:IPR036544|mint:P14927|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|refseq:NP_006285.1|refseq:NP_001186904.1|refseq:NP_001241681.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any uniprot ID. \n The appropriate uniprot ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:JEa3rOlDB4nVyYDniZrcnF9b1Wg9606 intact-crc:50F79D2CEF0F8000|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:O14949 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-720294|uniprotkb:Q5FVE2|uniprotkb:Q9BV88|uniprotkb:Q9T2V7|ensembl:ENSP00000367934|ensembl:ENSP00000367936|ensembl:ENSP00000367939 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:qcr8_human(display_long)|uniprotkb:Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C(gene name synonym)|uniprotkb:Ubiquinol-cytochrome c reductase complex 9.5 kDa protein(gene name synonym)|uniprotkb:Complex III subunit VIII(gene name synonym)|uniprotkb:Complex III subunit 8(gene name synonym)|uniprotkb:UQCRQ(gene name)|psi-mi:UQCRQ(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606656|imex:IM-20431-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 refseq:NP_055217.2|go:"GO:0021854"(hypothalamus development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0030901"(midbrain development)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004205(UcrQ)|interpro:IPR036642|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|ensembl:ENST00000378665(transcript)|ensembl:ENST00000378667(transcript)|ensembl:ENST00000378670(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0021539"(subthalamus development)|go:"GO:0021548"(pons development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|ensembl:ENSG00000164405(gene)|go:"GO:0021766"(hippocampus development)|go:"GO:0021794"(thalamus development) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any uniprot ID. \n The appropriate uniprot ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:z3gRHzrSJVEiHxsbAKU0jHYkMIc9606 intact-crc:50F79D2CEF0F8000|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:Q9UDW1 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-1224495|uniprotkb:B5MCM5|uniprotkb:Q9T2V6|ensembl:ENSP00000332887 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:qcr9_human(display_long)|uniprotkb:UQCR10(gene name)|psi-mi:UQCR10(display_short)|uniprotkb:HSPC119(orf name)|uniprotkb:UCRC(gene name synonym)|uniprotkb:Ubiquinol-cytochrome c reductase complex 7.2 kDa protein(gene name synonym)|uniprotkb:Cytochrome c1 non-heme 7 kDa protein(gene name synonym)|uniprotkb:Complex III subunit X(gene name synonym)|uniprotkb:Complex III subunit 9(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606656|imex:IM-20431-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 refseq:NP_001003684.1|refseq:NP_037519.2|interpro:IPR036656|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|ensembl:ENSG00000184076(gene)|ensembl:ENST00000330029(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|interpro:IPR008027(Ubiquinol-cytochrome C reductase, UQCRX/QCR9-like) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any uniprot ID. \n The appropriate uniprot ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:DDANQjwNz4ft+SVqOawiqaxueJk9606 intact-crc:50F79D2CEF0F8000|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:P47985 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-1045520|uniprotkb:Q6NVX5|uniprotkb:Q9UPH2|uniprotkb:A8K519|ensembl:ENSP00000306397 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:ucri_human(display_long)|uniprotkb:Ubiquinol-cytochrome c reductase iron-sulfur subunit(gene name synonym)|uniprotkb:Rieske iron-sulfur protein(gene name synonym)|uniprotkb:Complex III subunit 5(gene name synonym)|uniprotkb:Rieske protein UQCRFS1(gene name synonym)|uniprotkb:UQCRFS1(gene name)|psi-mi:UQCRFS1(display_short)|uniprotkb:Cytochrome b-c1 complex subunit 5(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606656|imex:IM-20431-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 refseq:NP_005994.2|ensembl:ENSG00000169021(gene)|ensembl:ENST00000304863(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR004192(Ubiquinol cytochrome reductase transmembrane region)|interpro:IPR005805(Rieske iron-sulphur protein, C-terminal)|interpro:IPR006317(Ubiquinol-cytochrome c reductase, iron-sulphur subunit)|interpro:IPR011070(Globular protein, non-globular alpha/beta subunit)|interpro:IPR014349(Rieske iron-sulphur protein)|interpro:IPR015248(Ubiquinol-cytochrome c reductase 8 kDa, N-terminal)|interpro:IPR017941|interpro:IPR036922|interpro:IPR037008|mint:P47985|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any uniprot ID. \n The appropriate uniprot ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:uBXz1yLEfiKg0/8rti+BnA5G9Nk9606 intact-crc:50F79D2CEF0F8000|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P13073 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606674|imex:IM-20431-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:19D17054B0356AA1|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P20674 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606674|imex:IM-20431-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 intact-crc:19D17054B0356AA1|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P10606 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606674|imex:IM-20431-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 intact-crc:19D17054B0356AA1|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P09669 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606674|imex:IM-20431-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 intact-crc:19D17054B0356AA1|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P15954 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-2606678|uniprotkb:Q6NR81|ensembl:ENSP00000247655|ensembl:ENSP00000425759 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox7c_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide VIIc(gene name synonym)|uniprotkb:COX7C(gene name)|psi-mi:COX7C(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606674|imex:IM-20431-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001858.1|ensembl:ENST00000247655(transcript)|ensembl:ENST00000509578(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004202(Cytochrome c oxidase subunit VIIc)|interpro:IPR036636|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|ensembl:ENSG00000127184(gene) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:hBYR7f5I8aE5H8JreIvHF8tg1HU9606 intact-crc:19D17054B0356AA1|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P14854 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-1047480|uniprotkb:Q6IBL4|uniprotkb:B2R5C9|ensembl:ENSP00000376037|ensembl:ENSP00000466818|ensembl:ENSP00000497926 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cx6b1_human(display_long)|uniprotkb:COX6B1(gene name)|psi-mi:COX6B1(display_short)|uniprotkb:COX6B(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIb isoform 1(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606674|imex:IM-20431-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001854.1|ensembl:ENSG00000126267(gene)|ensembl:ENST00000392201(transcript)|ensembl:ENST00000592141(transcript)|ensembl:ENST00000649813(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:YuBPGRO9+EC9fWz+mWALa2DyZL89606 intact-crc:19D17054B0356AA1|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P14406 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-2606666|uniprotkb:Q5TF59|uniprotkb:Q6FGI2|uniprotkb:Q3MIH5|uniprotkb:B2R5E1|ensembl:ENSP00000506727 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cx7a2_human(display_long)|uniprotkb:COX7AL(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIIa-liver/heart(gene name synonym)|uniprotkb:COX7A2(gene name)|psi-mi:COX7A2(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606674|imex:IM-20431-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001856.2|ensembl:ENSG00000112695(gene)|ensembl:ENST00000684430(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR003177(Cytochrome c oxidase, subunit VIIa)|interpro:IPR036539|interpro:IPR039297|mint:P14406|rcsb pdb:5Z62 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:krjTK658npBV4G6gH28GJhVqBkY9606 intact-crc:19D17054B0356AA1|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:O75947 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P56385 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-2270000|uniprotkb:Q0D2L9|ensembl:ENSP00000306003 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5i_human(display_long)|uniprotkb:ATP5ME(gene name)|psi-mi:ATP5ME(display_short)|uniprotkb:ATP5I(gene name synonym)|uniprotkb:ATP synthase membrane subunit e(gene name synonym)|uniprotkb:ATP5K(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_009031.1|ensembl:ENSG00000169020(gene)|ensembl:ENST00000304312(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR008386(ATPase, F0 complex, subunit E, mitochondrial)|mint:P56385|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:NYpqzWQYASXwSwU/BYDTMU2tJjI9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P18859 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:O75964 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-1044001|uniprotkb:Q96BV6|uniprotkb:Q9UBZ7|ensembl:ENSP00000300688|uniprotkb:A8K0K3 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5l_human(display_long)|uniprotkb:ATP5MG(gene name)|psi-mi:ATP5MG(display_short)|uniprotkb:ATP synthase membrane subunit g(gene name synonym)|uniprotkb:ATP5L(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_006467.4|ensembl:ENSG00000167283(gene)|ensembl:ENST00000300688(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR006808(ATPase, F0 complex, subunit G, mitochondrial)|interpro:IPR016702(Mitochondrial ATP synthase subunit g, animal)|mint:O75964|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:mn5/fFqk4xCCHb/MEuLAi5/lqmI9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:Q99766 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-2606691|uniprotkb:A8K1U3|uniprotkb:Q8WWX3|uniprotkb:Q96F77|uniprotkb:D9N156|ensembl:ENSP00000245448|ensembl:ENSP00000451583 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5s_human(display_long)|uniprotkb:DMAC2L(gene name)|psi-mi:DMAC2L(display_short)|uniprotkb:ATP synthase-coupling factor B(gene name synonym)|uniprotkb:ATP5S(gene name synonym)|uniprotkb:ATPW(gene name synonym)|uniprotkb:Distal membrane arm assembly complex 2-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP synthase regulatory component factor B(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:XP_011534958.1|refseq:NP_001003803.1|refseq:NP_001003805.1|refseq:NP_056499.2|ensembl:ENSG00000125375(gene)|ensembl:ENST00000245448(transcript)|ensembl:ENST00000554204(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0046872"(metal ion binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR032675|reactome:R-HSA-163210|reactome:R-HSA-8949613|interpro:IPR026063 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:GPVnfDsgz7Ee1O/MFjd+MC/yxzI9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P25705 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P06576 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P30049 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-1049505|uniprotkb:Q6FG90|uniprotkb:D6W5Y3|ensembl:ENSP00000215375|ensembl:ENSP00000378995|ensembl:ENSP00000464863 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpd_human(display_long)|uniprotkb:ATP5F1D(gene name)|psi-mi:ATP5F1D(display_short)|uniprotkb:ATP synthase F1 subunit delta(gene name synonym)|uniprotkb:ATP5D(gene name synonym)|uniprotkb:F-ATPase delta subunit(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001001975.1|refseq:NP_001678.1|ensembl:ENSG00000099624(gene)|ensembl:ENST00000215375(transcript)|ensembl:ENST00000395633(transcript)|ensembl:ENST00000591660(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046688"(response to copper ion)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR001469(ATPase, F1 complex, delta/epsilon subunit)|interpro:IPR020546|interpro:IPR036771|interpro:IPR036794|mint:P30049|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:OA8if7wpjwV6hkkaLqPyz6YDljc9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P36542 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P56134 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-712794|ensembl:ENSP00000292475|uniprotkb:O76079|uniprotkb:Q96L83|uniprotkb:Q9BTI8|uniprotkb:C9J8H9|uniprotkb:F8W7V3|intact:EBI-11047094|uniprotkb:Q6IBB3 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpk_human(display_long)|uniprotkb:ATP5MF(gene name)|psi-mi:ATP5MF(display_short)|uniprotkb:ATP synthase membrane subunit f(gene name synonym)|uniprotkb:ATP5J2(gene name synonym)|uniprotkb:ATP5JL(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606697|imex:IM-20431-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) ensembl:ENSG00000241468(gene)|ensembl:ENST00000292475(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR019344|mint:P56134|reactome:R-HSA-163210|reactome:R-HSA-8949613|refseq:NP_001003713.1|refseq:NP_004880.1|refseq:NP_001003714.1|refseq:NP_001034267.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:+WS7rjFef6JE+mlZ4Q8TF2A+G0E9606 intact-crc:3E115D071538FCC7|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O00483 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1049381|uniprotkb:Q6FHN5|uniprotkb:A4D109|ensembl:ENSP00000339720 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua4_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase MLRQ subunit(gene name synonym)|uniprotkb:Complex I-MLRQ(gene name synonym)|uniprotkb:NDUFA4(gene name)|psi-mi:NDUFA4(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002480.1|ensembl:ENSG00000189043(gene)|ensembl:ENST00000339600(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|interpro:IPR010530(B12D)|mint:O00483|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:TnrYlkH8abl42/yGsvfc8Bh6Mu09606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q16718 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-746417|uniprotkb:Q6IRX7|uniprotkb:Q5H9R2|uniprotkb:B2RD98|ensembl:ENSP00000347988 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua5_human(display_long)|uniprotkb:Complex I subunit B13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-B subunit(gene name synonym)|uniprotkb:Complex I-13kD-B(gene name synonym)|uniprotkb:NDUFA5(gene name)|psi-mi:NDUFA5(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004991.1|refseq:NP_001269348.1|refseq:NP_001269350.1|refseq:NP_001269351.1|ensembl:ENSG00000128609(gene)|ensembl:ENST00000355749(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR006806(ETC complex I subunit)|mint:Q16718|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408|refseq:NP_001269349.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:t042+V0dLA6z/X1MQdgkt7ya7qs9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P56556 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-714658|uniprotkb:O43675|uniprotkb:Q6IC39|uniprotkb:B2RE54|uniprotkb:Q6FGW0|uniprotkb:Q6IBT8|ensembl:ENSP00000418842|ensembl:ENSP00000475402|ensembl:ENSP00000486781|ensembl:ENSP00000487431|ensembl:ENSP00000487462 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua6_human(display_long)|uniprotkb:LYRM6(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B14 subunit(gene name synonym)|uniprotkb:Complex I-B14(gene name synonym)|uniprotkb:LYR motif-containing protein 6(gene name synonym)|uniprotkb:NDUFA6(gene name)|psi-mi:NDUFA6(display_short)|uniprotkb:NADHB14(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002481.2|ensembl:ENSG00000184983(gene)|ensembl:ENSG00000272765(gene)|ensembl:ENSG00000273397(gene)|ensembl:ENSG00000277365(gene)|ensembl:ENSG00000281013(gene)|ensembl:ENST00000498737(transcript)|ensembl:ENST00000605916(transcript)|ensembl:ENST00000628740(transcript)|ensembl:ENST00000630201(transcript)|ensembl:ENST00000630971(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR016488("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6")|mint:P56556|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:rI1B6Ym+ps0tKfJIClYRtej8KcU9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O95182 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-721471|ensembl:ENSP00000301457|ensembl:ENSP00000470962 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua7_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B14.5a(gene name synonym)|uniprotkb:Complex I-B14.5a(gene name synonym)|uniprotkb:NDUFA7(gene name)|psi-mi:NDUFA7(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004992.2|ensembl:ENSG00000267855(gene)|ensembl:ENST00000301457(transcript)|ensembl:ENST00000593729(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032543"(mitochondrial translation)|interpro:IPR009947("NADH:ubiquinone oxidoreductase subunit B14.5a")|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:FUdu0Oxjx6fLyDbe6WDbyfwKZW89606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P51970 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1237250|uniprotkb:B1AM93|uniprotkb:Q9Y6N0|ensembl:ENSP00000362873 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua8_human(display_long)|uniprotkb:NDUFA8(gene name)|psi-mi:NDUFA8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 19 kDa subunit(gene name synonym)|uniprotkb:Complex I-19kD(gene name synonym)|uniprotkb:Complex I-PGIV(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_055037.1|ensembl:ENSG00000119421(gene)|ensembl:ENST00000373768(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR010625(CHCH)|interpro:IPR016680("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8")|mint:P51970|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:buGk0RR4rNyaFDdsjenBqzYzlMs9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q16795 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1045087|uniprotkb:Q14076|uniprotkb:Q2NKX0|ensembl:ENSP00000266544 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndua9_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 39 kDa subunit(gene name synonym)|uniprotkb:Complex I-39kD(gene name synonym)|uniprotkb:NDUFA9(gene name)|psi-mi:NDUFA9(display_short)|uniprotkb:NDUFS2L(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004993.1|ensembl:ENSG00000139180(gene)|ensembl:ENST00000266544(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009749"(response to glucose)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1901006"(ubiquinone-6 biosynthetic process)|interpro:IPR001509(NAD-dependent epimerase/dehydratase)|interpro:IPR036291|mint:Q16795|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|dip:DIP-38526N - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:eM2zUsbdjMEILIcUedVOyEMwAzU9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O95299 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246361|uniprotkb:Q8WXC9|ensembl:ENSP00000252711|ensembl:ENSP00000503956|ensembl:ENSP00000504765 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduaa_human(display_long)|uniprotkb:NDUFA10(gene name)|psi-mi:NDUFA10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 42 kDa subunit(gene name synonym)|uniprotkb:Complex I-42kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004535.1|ensembl:ENSG00000130414(gene)|ensembl:ENST00000252711(transcript)|ensembl:ENST00000676929(transcript)|ensembl:ENST00000678158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR015828(NADH-ubiquinone oxidoreductase, 42 kDa subunit)|interpro:IPR027417|interpro:IPR031314|mint:O95299|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:8jwJPJ0rD9H7A4AzxPd186tpXYs9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q86Y39 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246415|uniprotkb:Q6ZS66|uniprotkb:C9JT23|ensembl:ENSP00000311740 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduab_human(display_long)|uniprotkb:NDUFA11(gene name)|psi-mi:NDUFA11(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B14.7(gene name synonym)|uniprotkb:Complex I-B14.7(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_783313.1|refseq:NP_001180304.1|ensembl:ENSG00000174886(gene)|ensembl:ENST00000308961(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039205|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:w6WASokPDfLWJ57ntErW7LgdpBA9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q9UI09 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246332|uniprotkb:Q9BRV6|uniprotkb:Q53XX0|uniprotkb:F8VQS7|ensembl:ENSP00000330737 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduac_human(display_long)|uniprotkb:NDUFA12(gene name)|psi-mi:NDUFA12(display_short)|uniprotkb:DAP13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B17.2(gene name synonym)|uniprotkb:Complex I-B17.2(gene name synonym)|uniprotkb:13 kDa differentiation-associated protein(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_061326.1|refseq:NP_001245267.1|ensembl:ENSG00000184752(gene)|ensembl:ENST00000327772(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR007763("NADH:ubiquinone oxidoreductase 17.2 kD subunit")|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:bQJVtT1ycebwYktMsNrejTZmG4k9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q9P0J0 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-372742|uniprotkb:Q6PKI0|uniprotkb:Q9H2L3|uniprotkb:Q9Y327|uniprotkb:B4DF76|uniprotkb:K7EK58|ensembl:ENSP00000423673 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduad_human(display_long)|uniprotkb:NDUFA13(gene name)|psi-mi:NDUFA13(display_short)|uniprotkb:CGI-39(orf name)|uniprotkb:CDA016(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase B16.6 subunit(gene name synonym)|uniprotkb:Complex I-B16.6(gene name synonym)|uniprotkb:Gene associated with retinoic and interferon-induced mortality 19 protein(gene name synonym)|uniprotkb:Cell death regulatory protein GRIM-19(gene name synonym)|uniprotkb:GRIM19(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_057049.5|go:"GO:0005524"(ATP binding)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR009346(GRIM-19)|mint:Q9P0J0|rcsb pdb:5XTB|rcsb pdb:5XTC|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|ensembl:ENSG00000186010(gene)|ensembl:ENST00000507754(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|dip:DIP-31180N - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:X5AsKHIxU5kpNVjY37UbZXG/Kns9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O43676 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-718365|uniprotkb:Q6IB80|ensembl:ENSP00000237889|ensembl:ENSP00000401834|ensembl:ENSP00000407336|ensembl:ENSP00000410600|ensembl:ENSP00000507925|ensembl:ENSP00000508132|ensembl:ENSP00000508208 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub3_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase B12 subunit(gene name synonym)|uniprotkb:Complex I-B12(gene name synonym)|uniprotkb:NDUFB3(gene name)|psi-mi:NDUFB3(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002482.1|refseq:XP_011509532.1|refseq:XP_016859675.1|refseq:NP_001244031.1|ensembl:ENSP00000237889|ensembl:ENSP00000410600|ensembl:ENSP00000401834|ensembl:ENSP00000407336|ensembl:ENSP00000507925|ensembl:ENSP00000508132|ensembl:ENSP00000508208|ensembl:ENSG00000119013(gene)|ensembl:ENST00000237889(transcript)|ensembl:ENST00000433898(transcript)|ensembl:ENST00000450023(transcript)|ensembl:ENST00000454214(transcript)|ensembl:ENST00000682325(transcript)|ensembl:ENST00000684175(transcript)|ensembl:ENST00000684420(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR012576(NADH-ubiquinone oxidoreductase B12 subunit)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:APgw3aIZyyqiPCXMFJ9dUYPQhVE9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O43674 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246293|uniprotkb:Q561V6|ensembl:ENSP00000259037 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub5_human(display_long)|uniprotkb:NDUFB5(gene name)|psi-mi:NDUFB5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase SGDH subunit(gene name synonym)|uniprotkb:Complex I-SGDH(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001186886.1|refseq:NP_001186887.1|refseq:NP_002483.1|ensembl:ENSG00000136521(gene)|ensembl:ENST00000259037(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019173|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:1UrbNq39EsuKHJ2M7tRd8ZmB6uk9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P17568 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246238|uniprotkb:Q9UI16|uniprotkb:Q6ICN9|ensembl:ENSP00000215565 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub7_human(display_long)|uniprotkb:NDUFB7(gene name)|psi-mi:NDUFB7(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B18 subunit(gene name synonym)|uniprotkb:Complex I-B18(gene name synonym)|uniprotkb:Cell adhesion protein SQM1(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004137.2|ensembl:ENSG00000099795(gene)|ensembl:ENST00000215565(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008698(NADH-ubiquinone oxidoreductase B18 subunit)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:9ghtJGrnow8MT1PKXEV2aYuzk0w9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O95169 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-716238|uniprotkb:Q5W144|uniprotkb:Q9UG53|uniprotkb:Q9UJR4|uniprotkb:Q9UQF3|uniprotkb:A8K0L4|intact:EBI-11021395|uniprotkb:Q5W143|uniprotkb:Q5W145|intact:EBI-28971189|ensembl:ENSP00000299166 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub8_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase ASHI subunit(gene name synonym)|uniprotkb:Complex I-ASHI(gene name synonym)|uniprotkb:NDUFB8(gene name)|psi-mi:NDUFB8(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 ensembl:ENSP00000299166|ensembl:ENST00000370320|ensembl:ENSP00000359344|ensembl:ENST00000370322|ensembl:ENSP00000359346|refseq:NP_004995.1|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008699(NADH-ubiquinone oxidoreductase ASHI subunit)|interpro:IPR016551("NADH dehydrogenase [ubiquinone] (complex I), beta subcomplex, subunit 8")|rcsb pdb:5XTC|rcsb pdb:5XTD|ensembl:ENSG00000166136(gene)|ensembl:ENST00000299166(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|refseq:NP_001271296.1|refseq:NP_001271297.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:iHF93OOQynl/ZBrUOOp9sAbDZkw9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q9Y6M9 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-713654|uniprotkb:Q9UQE8|uniprotkb:B2R8M6|ensembl:ENSP00000276689|ensembl:ENSP00000504235 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndub9_human(display_long)|uniprotkb:LYRM3(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B22 subunit(gene name synonym)|uniprotkb:Complex I-B22(gene name synonym)|uniprotkb:LYR motif-containing protein 3(gene name synonym)|uniprotkb:NDUFB9(gene name)|psi-mi:NDUFB9(display_short)|uniprotkb:UQOR22(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 rcsb pdb:5XTH|rcsb pdb:5XTD|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000147684(gene)|ensembl:ENST00000276689(transcript)|ensembl:ENST00000677021(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR033034|mint:Q9Y6M9|rcsb pdb:5XTC|refseq:NP_001298097.1|refseq:NP_004996.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:sNQcYhIFMHZA5T6MeeiwAeAJ5Gs9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O96000 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:Q9NX14 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246182|uniprotkb:Q5JRR3|uniprotkb:Q5JRR4|uniprotkb:Q6IAB6|uniprotkb:Q8WZ96|uniprotkb:Q9BXX9|ensembl:ENSP00000367042 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndubb_human(display_long)|uniprotkb:NDUFB11(gene name)|psi-mi:NDUFB11(display_short)|uniprotkb:UNQ111/PRO1064(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase ESSS subunit(gene name synonym)|uniprotkb:Complex I-ESSS(gene name synonym)|uniprotkb:Neuronal protein 17.3(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001129470.1|refseq:NP_061929.2|ensembl:ENSG00000147123(gene)|ensembl:ENST00000377811(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019329|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:CAloB+PJ0fcnLukpvgNGgTFJ0zs9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O95298 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246172|uniprotkb:Q9UBJ9|uniprotkb:Q6FIH8|uniprotkb:Q549M5|uniprotkb:E9PNU8|uniprotkb:E9PRB2|ensembl:ENSP00000281031 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduc2_human(display_long)|uniprotkb:NDUFC2(gene name)|psi-mi:NDUFC2(display_short)|uniprotkb:HLC1(orf name)|uniprotkb:NADH-ubiquinone oxidoreductase subunit B14.5b(gene name synonym)|uniprotkb:Complex I-B14.5b(gene name synonym)|uniprotkb:Human lung cancer oncogene 1 protein(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004540.1|refseq:NP_001190983.1|refseq:NP_001190984.1|ensembl:ENSG00000151366(gene)|ensembl:ENST00000281031(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005886"(plasma membrane)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035577"(azurophil granule membrane)|interpro:IPR009423(NADH-ubiquinone oxidoreductase subunit b14.5b)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6798695|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:IILkKsJHyRjCMZJ6z//WjdRXQUQ9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P28331 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O75306 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O75489 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 - - crc64:C058D62779BEF17B figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O43181 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246139|uniprotkb:Q9BS69|ensembl:ENSP00000296684 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus4_human(display_long)|uniprotkb:NDUFS4(gene name)|psi-mi:NDUFS4(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 18 kDa subunit(gene name synonym)|uniprotkb:Complex I-18 kDa(gene name synonym)|uniprotkb:Complex I-AQDQ(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002486.1|ensembl:ENSG00000164258(gene)|ensembl:ENST00000296684(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007420"(brain development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR006885(ETC complex I subunit conserved region)|interpro:IPR038532|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:T/NnuQagNs7EnceU9XKo4eUdy2o9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O43920 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246091|ensembl:ENSP00000362058|ensembl:ENSP00000362060 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus5_human(display_long)|uniprotkb:NDUFS5(gene name)|psi-mi:NDUFS5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 15 kDa subunit(gene name synonym)|uniprotkb:Complex I-15 kDa(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001171908.1|refseq:NP_004543.1|ensembl:ENSG00000168653(gene)|ensembl:ENST00000372967(transcript)|ensembl:ENST00000372969(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019342|mint:O43920|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:q74OuEXKdyCuxrUujwHeZjkW2gY9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O75380 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-719854|ensembl:ENSP00000274137 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus6_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-A subunit(gene name synonym)|uniprotkb:Complex I-13kD-A(gene name synonym)|uniprotkb:NDUFS6(gene name)|psi-mi:NDUFS6(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_004544.1|ensembl:ENSG00000145494(gene)|ensembl:ENST00000274137(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|interpro:IPR016668("NADH dehydrogenase [ubiquinone] (complex I), iron-sulphur protein 6, mitochondria")|interpro:IPR019401|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:IfpFyQjgJW6a8wA2pNw14stMUL49606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O75251 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-719652|uniprotkb:Q2T9H7|uniprotkb:Q9BV17|ensembl:ENSP00000233627|uniprotkb:B3KRI2 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus7_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 20 kDa subunit(gene name synonym)|uniprotkb:Complex I-20kD(gene name synonym)|uniprotkb:PSST subunit(gene name synonym)|uniprotkb:NDUFS7(gene name)|psi-mi:NDUFS7(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_077718.3|ensembl:ENSG00000115286(gene)|ensembl:ENST00000233627(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048038"(quinone binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097060"(synaptic membrane)|interpro:IPR006137(NADH ubiquinone oxidoreductase, 20 kDa subunit)|interpro:IPR006138("NADH dehydrogenase (ubiquinone), 20 kDa subunit")|mint:O75251|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:DtNXT30ApcGKwTJSdNNwHd/q3+09606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:O00217 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246309|uniprotkb:Q0VDA8|uniprotkb:B2RB86|ensembl:ENSP00000315774 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:ndus8_human(display_long)|uniprotkb:NDUFS8(gene name)|psi-mi:NDUFS8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 23 kDa subunit(gene name synonym)|uniprotkb:Complex I-23kD(gene name synonym)|uniprotkb:TYKY subunit(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_002487.1|refseq:XP_011543355.1|refseq:XP_005274070.1|refseq:XP_005274071.1|ensembl:ENSG00000110717(gene)|ensembl:ENST00000313468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR010226(NADH-quinone oxidoreductase, chain I)|interpro:IPR017896|interpro:IPR017900|mint:O00217|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:VzxtzGTNMccCfBDeDy9LKDN5V289606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P49821 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-748312|uniprotkb:Q6IBR3|uniprotkb:O60924|uniprotkb:O60940|uniprotkb:Q16104|uniprotkb:Q96BF8|uniprotkb:Q96HS7|ensembl:ENSP00000322450|ensembl:ENSP00000497587 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduv1_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 51 kDa subunit(gene name synonym)|uniprotkb:Complex I-51kD(gene name synonym)|uniprotkb:NADH dehydrogenase flavoprotein 1(gene name synonym)|uniprotkb:NDUFV1(gene name)|psi-mi:NDUFV1(display_short)|uniprotkb:UQOR1(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001159574.1|refseq:NP_009034.2|ensembl:ENSG00000167792(gene)|ensembl:ENST00000322776(transcript)|ensembl:ENST00000647561(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010181"(FMN binding)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001949(NADH-ubiquinone oxidoreductase, 51 kDa subunit, conserved site)|interpro:IPR011537(NADH-ubiquinone oxidoreductase, F subunit)|interpro:IPR011538(NADH-ubiquinone oxidoreductase, 51 kDa subunit)|interpro:IPR019554|interpro:IPR019575|interpro:IPR037207|interpro:IPR037225|mint:P49821|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:0pEd6isDBEamZQJ5QNo5yJ7rKu89606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P19404 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-713665|uniprotkb:Q9BV41|ensembl:ENSP00000327268 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduv2_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 24 kDa subunit(gene name synonym)|uniprotkb:NDUFV2(gene name)|psi-mi:NDUFV2(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 ensembl:ENSG00000178127(gene)|ensembl:ENST00000318388(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002023("NADH dehydrogenase (ubiquinone), 24 kDa subunit")|interpro:IPR036249|interpro:IPR041921|interpro:IPR042128|mint:P19404|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|refseq:NP_066552.2 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:5cG/vsBAIJGKAkWlM0S/rmqJqGM9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P56181 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-721902|uniprotkb:Q6FGD3|uniprotkb:Q9HCR5|uniprotkb:A8K0M1|uniprotkb:Q8WU60|uniprotkb:J3KNX7|ensembl:ENSP00000342895 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nduv3_human(display_long)|uniprotkb:Complex I-9kD(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-4(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 9 kDa subunit(gene name synonym)|uniprotkb:NDUFV3(gene name)|psi-mi:NDUFV3(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:NP_001001503.1|refseq:NP_066553.3|ensembl:ENSG00000160194(gene)|ensembl:ENST00000340344(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|interpro:IPR026193|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:YW1NUj6P01jeBW0dhRhVQaqg7qY9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P03886 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246156|uniprotkb:Q37523|uniprotkb:C0JKH6|ensembl:ENSP00000354687 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nu1m_human(display_long)|uniprotkb:MT-ND1(gene name)|psi-mi:MT-ND1(display_short)|uniprotkb:MTND1(gene name synonym)|uniprotkb:NADH1(gene name synonym)|uniprotkb:ND1(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 1(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:YP_003024026.1|ensembl:ENSG00000198888(gene)|ensembl:ENST00000361390(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|interpro:IPR001694(Respiratory-chain NADH dehydrogenase, subunit 1)|interpro:IPR018086|mint:P03886|rcsb pdb:5XTC|rcsb pdb:5XTD|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:AZoXs+VEdQPt/9D2lr+qBuwsZfA9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43678 uniprotkb:P03905 intact:EBI-1246398|uniprotkb:Q6IAY8|uniprotkb:D6RJD6|ensembl:ENSP00000252102 intact:EBI-1246274|uniprotkb:Q6RL39|uniprotkb:Q6RQN9|uniprotkb:Q8HNR8|ensembl:ENSP00000354961 psi-mi:ndua2_human(display_long)|uniprotkb:NDUFA2(gene name)|psi-mi:NDUFA2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B8 subunit(gene name synonym)|uniprotkb:Complex I-B8(gene name synonym) psi-mi:nu4m_human(display_long)|uniprotkb:MT-ND4(gene name)|psi-mi:MT-ND4(display_short)|uniprotkb:MTND4(gene name synonym)|uniprotkb:NADH4(gene name synonym)|uniprotkb:ND4(gene name synonym)|uniprotkb:NADH dehydrogenase subunit 4(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606724|imex:IM-20431-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002479.1|refseq:NP_001171941.1|ensembl:ENSG00000131495(gene)|ensembl:ENST00000252102(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR016464("NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2")|interpro:IPR036249|rcsb pdb:1S3A|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 refseq:YP_003024035.1|ensembl:ENSG00000198886(gene)|ensembl:ENST00000361381(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007568"(aging)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0021549"(cerebellum development)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0035094"(response to nicotine)|go:"GO:0045471"(response to ethanol)|go:"GO:0048039"(ubiquinone binding)|interpro:IPR000260(NADH-ubiquinone oxidoreductase chain 4, N-terminal)|interpro:IPR001750("NADH/Ubiquinone/plastoquinone (complex I)")|interpro:IPR003918(NADH-ubiquinone oxidoreductase, chain 4)|interpro:IPR010227(Proton-translocating NADH-quinone oxidoreductase, chain M)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - - - figure legend:Supplementary table 1, Fig. 2 A and B, Table 1 and supporting information Fig. 3|complex-properties:The authors identified 32 out of the 45 OXPHOS complexe I subunits|comment:The GI numbers 17981862, 21361822 and 38524585 do not match any UniProtKB IDs. The appropriate UniProtKB IDs are respectively P03905, Q9P0J0 and O75251 and match respectively 278, 9 and 7 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2018/07/05 rogid:bL66utte1nSuYj0nxg/BoktnXhs9606 rogid:O+b63kRTlmPDBdo6Oe90fRomfeY9606 intact-crc:7C22036851C18BE0|rigid:/Wf7/PC2r/ymCoeRl6T5FXkMC28 false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:P22695 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-1051424|uniprotkb:Q9BQ05|uniprotkb:B3KSN4|ensembl:ENSP00000268379 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:qcr2_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 2(gene name synonym)|uniprotkb:Core protein II(gene name synonym)|uniprotkb:Complex III subunit 2(gene name synonym)|uniprotkb:UQCRC2(gene name)|psi-mi:UQCRC2(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606766|imex:IM-20431-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 refseq:NP_003357.2|ensembl:ENSG00000140740(gene)|ensembl:ENST00000268379(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006508"(proteolysis)|go:"GO:0009060"(aerobic respiration)|go:"GO:0042493"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P22695|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any UniProtKB ID. The appropriate UniProtKB ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:++DmwaVpqzRyxFl7mh62L4ku4P09606 intact-crc:4C7C27537C27BE21|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:P14927 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-743128|ensembl:ENSP00000287022|uniprotkb:Q6FGD1|uniprotkb:E5RJU0 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:qcr7_human(display_long)|uniprotkb:Ubiquinol-cytochrome c reductase complex 14 kDa protein(gene name synonym)|uniprotkb:Complex III subunit 7(gene name synonym)|uniprotkb:Complex III subunit VII(gene name synonym)|uniprotkb:QP-C(gene name synonym)|uniprotkb:UQCRB(gene name)|psi-mi:UQCRB(display_short)|uniprotkb:UQBP(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606766|imex:IM-20431-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 ensembl:ENSG00000156467(gene)|ensembl:ENST00000287022(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0009060"(aerobic respiration)|interpro:IPR003197(Cytochrome bd ubiquinol oxidase, 14 kDa subunit)|interpro:IPR036544|mint:P14927|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|refseq:NP_006285.1|refseq:NP_001186904.1|refseq:NP_001241681.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any UniProtKB ID. The appropriate UniProtKB ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:JEa3rOlDB4nVyYDniZrcnF9b1Wg9606 intact-crc:4C7C27537C27BE21|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:O14949 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-720294|uniprotkb:Q5FVE2|uniprotkb:Q9BV88|uniprotkb:Q9T2V7|ensembl:ENSP00000367934|ensembl:ENSP00000367936|ensembl:ENSP00000367939 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:qcr8_human(display_long)|uniprotkb:Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C(gene name synonym)|uniprotkb:Ubiquinol-cytochrome c reductase complex 9.5 kDa protein(gene name synonym)|uniprotkb:Complex III subunit VIII(gene name synonym)|uniprotkb:Complex III subunit 8(gene name synonym)|uniprotkb:UQCRQ(gene name)|psi-mi:UQCRQ(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606766|imex:IM-20431-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 refseq:NP_055217.2|go:"GO:0021854"(hypothalamus development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0030901"(midbrain development)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004205(UcrQ)|interpro:IPR036642|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|ensembl:ENST00000378665(transcript)|ensembl:ENST00000378667(transcript)|ensembl:ENST00000378670(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0021539"(subthalamus development)|go:"GO:0021548"(pons development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|ensembl:ENSG00000164405(gene)|go:"GO:0021766"(hippocampus development)|go:"GO:0021794"(thalamus development) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any UniProtKB ID. The appropriate UniProtKB ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:z3gRHzrSJVEiHxsbAKU0jHYkMIc9606 intact-crc:4C7C27537C27BE21|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:Q9UDW1 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-1224495|uniprotkb:B5MCM5|uniprotkb:Q9T2V6|ensembl:ENSP00000332887 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:qcr9_human(display_long)|uniprotkb:UQCR10(gene name)|psi-mi:UQCR10(display_short)|uniprotkb:HSPC119(orf name)|uniprotkb:UCRC(gene name synonym)|uniprotkb:Ubiquinol-cytochrome c reductase complex 7.2 kDa protein(gene name synonym)|uniprotkb:Cytochrome c1 non-heme 7 kDa protein(gene name synonym)|uniprotkb:Complex III subunit X(gene name synonym)|uniprotkb:Complex III subunit 9(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606766|imex:IM-20431-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 refseq:NP_001003684.1|refseq:NP_037519.2|interpro:IPR036656|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|ensembl:ENSG00000184076(gene)|ensembl:ENST00000330029(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|interpro:IPR008027(Ubiquinol-cytochrome C reductase, UQCRX/QCR9-like) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any UniProtKB ID. The appropriate UniProtKB ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:DDANQjwNz4ft+SVqOawiqaxueJk9606 intact-crc:4C7C27537C27BE21|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31930 uniprotkb:P47985 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 intact:EBI-1045520|uniprotkb:Q6NVX5|uniprotkb:Q9UPH2|uniprotkb:A8K519|ensembl:ENSP00000306397 psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:ucri_human(display_long)|uniprotkb:Ubiquinol-cytochrome c reductase iron-sulfur subunit(gene name synonym)|uniprotkb:Rieske iron-sulfur protein(gene name synonym)|uniprotkb:Complex III subunit 5(gene name synonym)|uniprotkb:Rieske protein UQCRFS1(gene name synonym)|uniprotkb:UQCRFS1(gene name)|psi-mi:UQCRFS1(display_short)|uniprotkb:Cytochrome b-c1 complex subunit 5(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606766|imex:IM-20431-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 refseq:NP_005994.2|ensembl:ENSG00000169021(gene)|ensembl:ENST00000304863(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR004192(Ubiquinol cytochrome reductase transmembrane region)|interpro:IPR005805(Rieske iron-sulphur protein, C-terminal)|interpro:IPR006317(Ubiquinol-cytochrome c reductase, iron-sulphur subunit)|interpro:IPR011070(Globular protein, non-globular alpha/beta subunit)|interpro:IPR014349(Rieske iron-sulphur protein)|interpro:IPR015248(Ubiquinol-cytochrome c reductase 8 kDa, N-terminal)|interpro:IPR017941|interpro:IPR036922|interpro:IPR037008|mint:P47985|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 6 out of the 11 OXPHOS complexe III subunits|comment:The GI number 5174743 doesn't match any UniProtKB ID. The appropriate UniProtKB ID is P47985 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rogid:uBXz1yLEfiKg0/8rti+BnA5G9Nk9606 intact-crc:4C7C27537C27BE21|rigid:02IKiz6cs+ejNJUgyPcV9Cpq3Gc false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31040 uniprotkb:P21912 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606760|imex:IM-20431-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 2 out of the 4 OXPHOS complexe II subunits|comment:The GI number 4759080 does not match any UniProtKB ID. The appropriate UniProtKB ID is P31040 and matches 11 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 intact-crc:E43FFEBF68642032|rigid:4mTOLIFFsHkNnDKzk5xJysN8/Qk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P13073 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606776|imex:IM-20431-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:2F7F8800622F52E7|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P20674 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606776|imex:IM-20431-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 intact-crc:2F7F8800622F52E7|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P10606 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606776|imex:IM-20431-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 intact-crc:2F7F8800622F52E7|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P09669 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606776|imex:IM-20431-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 intact-crc:2F7F8800622F52E7|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P15954 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-2606678|uniprotkb:Q6NR81|ensembl:ENSP00000247655|ensembl:ENSP00000425759 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cox7c_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide VIIc(gene name synonym)|uniprotkb:COX7C(gene name)|psi-mi:COX7C(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606776|imex:IM-20431-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001858.1|ensembl:ENST00000247655(transcript)|ensembl:ENST00000509578(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004202(Cytochrome c oxidase subunit VIIc)|interpro:IPR036636|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|ensembl:ENSG00000127184(gene) - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:hBYR7f5I8aE5H8JreIvHF8tg1HU9606 intact-crc:2F7F8800622F52E7|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P14854 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-1047480|uniprotkb:Q6IBL4|uniprotkb:B2R5C9|ensembl:ENSP00000376037|ensembl:ENSP00000466818|ensembl:ENSP00000497926 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cx6b1_human(display_long)|uniprotkb:COX6B1(gene name)|psi-mi:COX6B1(display_short)|uniprotkb:COX6B(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIb isoform 1(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606776|imex:IM-20431-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001854.1|ensembl:ENSG00000126267(gene)|ensembl:ENST00000392201(transcript)|ensembl:ENST00000592141(transcript)|ensembl:ENST00000649813(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:YuBPGRO9+EC9fWz+mWALa2DyZL89606 intact-crc:2F7F8800622F52E7|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P00403 uniprotkb:P14406 intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876 intact:EBI-2606666|uniprotkb:Q5TF59|uniprotkb:Q6FGI2|uniprotkb:Q3MIH5|uniprotkb:B2R5E1|ensembl:ENSP00000506727 psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym) psi-mi:cx7a2_human(display_long)|uniprotkb:COX7AL(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIIa-liver/heart(gene name synonym)|uniprotkb:COX7A2(gene name)|psi-mi:COX7A2(display_short) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606776|imex:IM-20431-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 refseq:NP_001856.2|ensembl:ENSG00000112695(gene)|ensembl:ENST00000684430(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR003177(Cytochrome c oxidase, subunit VIIa)|interpro:IPR036539|interpro:IPR039297|mint:P14406|rcsb pdb:5Z62 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 8 out of the 13 OXPHOS complexe IV subunits|comment:The GI numbers 4758038 does not match any UniProtKB ID. The appropriate UniProtKB ID is P20674 and matches 9 different GI numbers.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:NyMmciQe53E935KEZahz8cGPjIM9606 rogid:krjTK658npBV4G6gH28GJhVqBkY9606 intact-crc:2F7F8800622F52E7|rigid:TAMrlMTZsyILbEek2FBRq35+tKk false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:O75947 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P56385 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-2270000|uniprotkb:Q0D2L9|ensembl:ENSP00000306003 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5i_human(display_long)|uniprotkb:ATP5ME(gene name)|psi-mi:ATP5ME(display_short)|uniprotkb:ATP5I(gene name synonym)|uniprotkb:ATP synthase membrane subunit e(gene name synonym)|uniprotkb:ATP5K(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_009031.1|ensembl:ENSG00000169020(gene)|ensembl:ENST00000304312(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR008386(ATPase, F0 complex, subunit E, mitochondrial)|mint:P56385|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:NYpqzWQYASXwSwU/BYDTMU2tJjI9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P18859 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:O75964 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-1044001|uniprotkb:Q96BV6|uniprotkb:Q9UBZ7|ensembl:ENSP00000300688|uniprotkb:A8K0K3 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5l_human(display_long)|uniprotkb:ATP5MG(gene name)|psi-mi:ATP5MG(display_short)|uniprotkb:ATP synthase membrane subunit g(gene name synonym)|uniprotkb:ATP5L(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_006467.4|ensembl:ENSG00000167283(gene)|ensembl:ENST00000300688(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR006808(ATPase, F0 complex, subunit G, mitochondrial)|interpro:IPR016702(Mitochondrial ATP synthase subunit g, animal)|mint:O75964|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:mn5/fFqk4xCCHb/MEuLAi5/lqmI9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:Q99766 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-2606691|uniprotkb:A8K1U3|uniprotkb:Q8WWX3|uniprotkb:Q96F77|uniprotkb:D9N156|ensembl:ENSP00000245448|ensembl:ENSP00000451583 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atp5s_human(display_long)|uniprotkb:DMAC2L(gene name)|psi-mi:DMAC2L(display_short)|uniprotkb:ATP synthase-coupling factor B(gene name synonym)|uniprotkb:ATP5S(gene name synonym)|uniprotkb:ATPW(gene name synonym)|uniprotkb:Distal membrane arm assembly complex 2-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP synthase regulatory component factor B(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:XP_011534958.1|refseq:NP_001003803.1|refseq:NP_001003805.1|refseq:NP_056499.2|ensembl:ENSG00000125375(gene)|ensembl:ENST00000245448(transcript)|ensembl:ENST00000554204(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0046872"(metal ion binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR032675|reactome:R-HSA-163210|reactome:R-HSA-8949613|interpro:IPR026063 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:GPVnfDsgz7Ee1O/MFjd+MC/yxzI9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P25705 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P06576 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P30049 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-1049505|uniprotkb:Q6FG90|uniprotkb:D6W5Y3|ensembl:ENSP00000215375|ensembl:ENSP00000378995|ensembl:ENSP00000464863 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpd_human(display_long)|uniprotkb:ATP5F1D(gene name)|psi-mi:ATP5F1D(display_short)|uniprotkb:ATP synthase F1 subunit delta(gene name synonym)|uniprotkb:ATP5D(gene name synonym)|uniprotkb:F-ATPase delta subunit(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001001975.1|refseq:NP_001678.1|ensembl:ENSG00000099624(gene)|ensembl:ENST00000215375(transcript)|ensembl:ENST00000395633(transcript)|ensembl:ENST00000591660(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046688"(response to copper ion)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR001469(ATPase, F1 complex, delta/epsilon subunit)|interpro:IPR020546|interpro:IPR036771|interpro:IPR036794|mint:P30049|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:OA8if7wpjwV6hkkaLqPyz6YDljc9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P36542 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-711768|uniprotkb:Q5VYP3|uniprotkb:Q96AS8|uniprotkb:A8KA31|intact:EBI-3962282|uniprotkb:Q6I9V2|ensembl:ENSP00000349142 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpg_human(display_long)|uniprotkb:ATP5F1C(gene name)|psi-mi:ATP5F1C(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:ATP5C(gene name synonym)|uniprotkb:ATP5C1(gene name synonym)|uniprotkb:ATP5CL1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) refseq:NP_001001973.1|refseq:NP_005165.1|ensembl:ENSG00000165629(gene)|ensembl:ENST00000356708(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|interpro:IPR035968|mint:P36542|reactome:R-HSA-163210|reactome:R-HSA-8949613 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:k3Nfa1hSoREyiKzFbmaZqxLhiLY9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24539 uniprotkb:P56134 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 intact:EBI-712794|ensembl:ENSP00000292475|uniprotkb:O76079|uniprotkb:Q96L83|uniprotkb:Q9BTI8|uniprotkb:C9J8H9|uniprotkb:F8W7V3|intact:EBI-11047094|uniprotkb:Q6IBB3 psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:atpk_human(display_long)|uniprotkb:ATP5MF(gene name)|psi-mi:ATP5MF(display_short)|uniprotkb:ATP synthase membrane subunit f(gene name synonym)|uniprotkb:ATP5J2(gene name synonym)|uniprotkb:ATP5JL(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606788|imex:IM-20431-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) ensembl:ENSG00000241468(gene)|ensembl:ENST00000292475(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR019344|mint:P56134|reactome:R-HSA-163210|reactome:R-HSA-8949613|refseq:NP_001003713.1|refseq:NP_004880.1|refseq:NP_001003714.1|refseq:NP_001034267.1 - - - figure legend:Supplementary table 1, Fig. 2 A and B|complex-properties:The authors identified 11 out of the 17 OXPHOS complexe V subunits|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 rogid:+WS7rjFef6JE+mlZ4Q8TF2A+G0E9606 intact-crc:699D077315CCFCA3|rigid:LI2RTMZ1mVj25LBd3OaEsPDiISE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75306 uniprotkb:O75489 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606811|imex:IM-20431-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 - - crc64:C058D62779BEF17B figure legend:Fig. 3. B|comment:"The subunits NDFUS2 and NDUFS3 seem to be found in 6 different complexes. (the mitochondrial respiratory chain complex I and 5 different holocomplexes or assembly intermediates)"|antibodies:primary antibodies against NDUFS2 and NDUFS3 for the immunoblot|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 intact-crc:0AE618D79C5CFB1F|rigid:/+PZ64dzKo0A8EDcvopBgAnyP1M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BU61 uniprotkb:Q9P032 intact:EBI-2114801|ensembl:ENSP00000323076 intact:EBI-2606839|uniprotkb:B2R4J5|ensembl:ENSP00000358272 psi-mi:nduf3_human(display_long)|uniprotkb:NDUFAF3(gene name)|psi-mi:NDUFAF3(display_short)|uniprotkb:C3orf60(gene name synonym) psi-mi:nduf4_human(display_long)|uniprotkb:NDUFAF4(gene name)|psi-mi:NDUFAF4(display_short)|uniprotkb:C6orf66(gene name synonym)|uniprotkb:HRPAP20(gene name synonym)|uniprotkb:Hormone-regulated proliferation-associated protein of 20 kDa(gene name synonym)|uniprotkb:HSPC125(orf name)|uniprotkb:My013(orf name) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606834|imex:IM-20431-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_951032.1|ensembl:ENSG00000178057(gene)|ensembl:ENST00000326925(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007523(Protein of unknown function DUF498)|interpro:IPR034095|interpro:IPR036748|reactome:R-HSA-6799198 refseq:NP_054884.1|ensembl:ENSG00000123545(gene)|ensembl:ENST00000316149(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051607"(defense response to virus)|interpro:IPR009622(Protein of unknown function UPF0240)|reactome:R-HSA-6799198 - - - figure legend:Fig. 4. A, B and C|comment:The subunits NDFUS2 and NDUFS3 and the proteins C3orf60 and C3orf66 seem to be found in 4 different complexes.|antibodies:primary antibodies against NDUFS2, NDUFS3, C3orf60 and C3orf66 for the immunoblot|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:FRuV8K4v6ogOA5pR2YVCnhRW5oQ9606 rogid:ZtOZIjES2EpHrKzLDdCxl08NKcI9606 intact-crc:BE844C257E799BCE|rigid:0b2bnqko3I5Cocg2RMxhb010bbU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BU61 uniprotkb:O75306 intact:EBI-2114801|ensembl:ENSP00000323076 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:nduf3_human(display_long)|uniprotkb:NDUFAF3(gene name)|psi-mi:NDUFAF3(display_short)|uniprotkb:C3orf60(gene name synonym) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606834|imex:IM-20431-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_951032.1|ensembl:ENSG00000178057(gene)|ensembl:ENST00000326925(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007523(Protein of unknown function DUF498)|interpro:IPR034095|interpro:IPR036748|reactome:R-HSA-6799198 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - - - figure legend:Fig. 4. A, B and C|comment:The subunits NDFUS2 and NDUFS3 and the proteins C3orf60 and C3orf66 seem to be found in 4 different complexes.|antibodies:primary antibodies against NDUFS2, NDUFS3, C3orf60 and C3orf66 for the immunoblot|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:FRuV8K4v6ogOA5pR2YVCnhRW5oQ9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 intact-crc:BE844C257E799BCE|rigid:0b2bnqko3I5Cocg2RMxhb010bbU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BU61 uniprotkb:O75489 intact:EBI-2114801|ensembl:ENSP00000323076 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 psi-mi:nduf3_human(display_long)|uniprotkb:NDUFAF3(gene name)|psi-mi:NDUFAF3(display_short)|uniprotkb:C3orf60(gene name synonym) psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606834|imex:IM-20431-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_951032.1|ensembl:ENSG00000178057(gene)|ensembl:ENST00000326925(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007523(Protein of unknown function DUF498)|interpro:IPR034095|interpro:IPR036748|reactome:R-HSA-6799198 refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 - - crc64:C058D62779BEF17B figure legend:Fig. 4. A, B and C|comment:The subunits NDFUS2 and NDUFS3 and the proteins C3orf60 and C3orf66 seem to be found in 4 different complexes.|antibodies:primary antibodies against NDUFS2, NDUFS3, C3orf60 and C3orf66 for the immunoblot|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:FRuV8K4v6ogOA5pR2YVCnhRW5oQ9606 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 intact-crc:BE844C257E799BCE|rigid:0b2bnqko3I5Cocg2RMxhb010bbU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75489 uniprotkb:O75306 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606827|imex:IM-20431-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - crc64:C058D62779BEF17B - figure legend:Fig. 3. B|comment:"The subunits NDFUS2 and NDUFS3 seem to be found in 6 different complexes. (the mitochondrial respiratory chain complex I and 5 different holocomplexes or assembly intermediates)"|antibodies:primary antibodies against NDUFS2 and NDUFS3 for the immunoblot|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 intact-crc:AE3825966321088C|rigid:/+PZ64dzKo0A8EDcvopBgAnyP1M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BU61 uniprotkb:Q9P032 intact:EBI-2114801|ensembl:ENSP00000323076 intact:EBI-2606839|uniprotkb:B2R4J5|ensembl:ENSP00000358272 psi-mi:nduf3_human(display_long)|uniprotkb:NDUFAF3(gene name)|psi-mi:NDUFAF3(display_short)|uniprotkb:C3orf60(gene name synonym) psi-mi:nduf4_human(display_long)|uniprotkb:NDUFAF4(gene name)|psi-mi:NDUFAF4(display_short)|uniprotkb:C6orf66(gene name synonym)|uniprotkb:HRPAP20(gene name synonym)|uniprotkb:Hormone-regulated proliferation-associated protein of 20 kDa(gene name synonym)|uniprotkb:HSPC125(orf name)|uniprotkb:My013(orf name) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606848|imex:IM-20431-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_951032.1|ensembl:ENSG00000178057(gene)|ensembl:ENST00000326925(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007523(Protein of unknown function DUF498)|interpro:IPR034095|interpro:IPR036748|reactome:R-HSA-6799198 refseq:NP_054884.1|ensembl:ENSG00000123545(gene)|ensembl:ENST00000316149(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051607"(defense response to virus)|interpro:IPR009622(Protein of unknown function UPF0240)|reactome:R-HSA-6799198 - - - figure legend:Fig. 4. A, B and C|comment:The subunits NDFUS2 and NDUFS3 and the proteins C3orf60 and C3orf66 seem to be found in 4 different complexes.|antibodies:primary antibodies against NDUFS2, NDUFS3, C3orf60 and C3orf66 for the immunoblot|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:FRuV8K4v6ogOA5pR2YVCnhRW5oQ9606 rogid:ZtOZIjES2EpHrKzLDdCxl08NKcI9606 intact-crc:ED25FA70FC95C06D|rigid:0b2bnqko3I5Cocg2RMxhb010bbU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BU61 uniprotkb:O75306 intact:EBI-2114801|ensembl:ENSP00000323076 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:nduf3_human(display_long)|uniprotkb:NDUFAF3(gene name)|psi-mi:NDUFAF3(display_short)|uniprotkb:C3orf60(gene name synonym) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606848|imex:IM-20431-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_951032.1|ensembl:ENSG00000178057(gene)|ensembl:ENST00000326925(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007523(Protein of unknown function DUF498)|interpro:IPR034095|interpro:IPR036748|reactome:R-HSA-6799198 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) - - - figure legend:Fig. 4. A, B and C|comment:The subunits NDFUS2 and NDUFS3 and the proteins C3orf60 and C3orf66 seem to be found in 4 different complexes.|antibodies:primary antibodies against NDUFS2, NDUFS3, C3orf60 and C3orf66 for the immunoblot|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:FRuV8K4v6ogOA5pR2YVCnhRW5oQ9606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 intact-crc:ED25FA70FC95C06D|rigid:0b2bnqko3I5Cocg2RMxhb010bbU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9BU61 uniprotkb:O75489 intact:EBI-2114801|ensembl:ENSP00000323076 intact:EBI-1224896|uniprotkb:Q9UNQ8|uniprotkb:B2R9J1|uniprotkb:B4DFM8|ensembl:ENSP00000263774|ensembl:ENSP00000496383 psi-mi:nduf3_human(display_long)|uniprotkb:NDUFAF3(gene name)|psi-mi:NDUFAF3(display_short)|uniprotkb:C3orf60(gene name synonym) psi-mi:ndus3_human(display_long)|uniprotkb:NDUFS3(gene name)|psi-mi:NDUFS3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 30 kDa subunit(gene name synonym)|uniprotkb:Complex I-30kD(gene name synonym) psi-mi:"MI:0276"(blue native page) Hans et al. (2009) pubmed:19688755|imex:IM-20431 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2606848|imex:IM-20431-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_951032.1|ensembl:ENSG00000178057(gene)|ensembl:ENST00000326925(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR007523(Protein of unknown function DUF498)|interpro:IPR034095|interpro:IPR036748|reactome:R-HSA-6799198 refseq:NP_004542.1|ensembl:ENSG00000213619(gene)|ensembl:ENSG00000285387(gene)|ensembl:ENST00000263774(transcript)|ensembl:ENST00000645714(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001268("NADH dehydrogenase (ubiquinone), 30 kDa subunit")|interpro:IPR010218("NADH (or F420H2) dehydrogenase, subunit C")|interpro:IPR020396|interpro:IPR037232|mint:O75489|go:"GO:0005739"(mitochondrion)|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408 - - crc64:C058D62779BEF17B figure legend:Fig. 4. A, B and C|comment:The subunits NDFUS2 and NDUFS3 and the proteins C3orf60 and C3orf66 seem to be found in 4 different complexes.|antibodies:primary antibodies against NDUFS2, NDUFS3, C3orf60 and C3orf66 for the immunoblot|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2010/03/01 2014/10/16 rogid:FRuV8K4v6ogOA5pR2YVCnhRW5oQ9606 rogid:DLJY8qzyEVTyAGgqIjBP24ymiSs9606 intact-crc:ED25FA70FC95C06D|rigid:0b2bnqko3I5Cocg2RMxhb010bbU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)