#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P34947	uniprotkb:P97288	intact:EBI-7149314|ensembl:ENSP00000376609|intact:MINT-3013589|uniprotkb:D3DRD0|uniprotkb:Q5T059	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	psi-mi:grk5_human(display_long)|uniprotkb:GRK5(gene name)|psi-mi:GRK5(display_short)|uniprotkb:GPRK5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149375|mint:MINT-7943386|imex:IM-14586-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198873(gene)|ensembl:ENST00000392870(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:4TNB|rcsb pdb:4TND|rcsb pdb:6PJX|reactome:R-HSA-416476|reactome:R-HSA-418555|refseq:NP_005299.1|dip:DIP-57457N|mint:MINT-7943389(identity)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943388(identity)	-	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	figure legend:f4a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/28	2014/10/16	rogid:Wrqm8jdsak0uuhSAvIhfxebfFQc9606	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	intact-crc:3E21090AF91DD9A0|rigid:cKX5geYsKGJAaxgAVp9HJN8b2GY	false	-	his tag:?-?(MINT-7943396)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97288	uniprotkb:P12931	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0096"(pull down)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149469|mint:MINT-7943578|imex:IM-14586-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943580(identity)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N|mint:MINT-7943584(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	-	figure legend:f9a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:1ADA5E91C13F74D0|rigid:E/vRqSt+RF++lIsTDXEXFmCIER4	false	his tag:?-?(MINT-7943581)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P34947	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-7149314|ensembl:ENSP00000376609|intact:MINT-3013589|uniprotkb:D3DRD0|uniprotkb:Q5T059	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:grk5_human(display_long)|uniprotkb:GRK5(gene name)|psi-mi:GRK5(display_short)|uniprotkb:GPRK5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149621|mint:MINT-7943403|imex:IM-14586-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943405(identity)	ensembl:ENSG00000198873(gene)|ensembl:ENST00000392870(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:4TNB|rcsb pdb:4TND|rcsb pdb:6PJX|reactome:R-HSA-416476|reactome:R-HSA-418555|refseq:NP_005299.1|dip:DIP-57457N|mint:MINT-7943409(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:Wrqm8jdsak0uuhSAvIhfxebfFQc9606	intact-crc:B89CDEFAA006C986|rigid:cKX5geYsKGJAaxgAVp9HJN8b2GY	false	mutation decreasing interaction:332-332(MINT-7943434)|myc tag:?-?(MINT-7943406)|mutation decreasing interaction:330-330(MINT-7943428)|mutation decreasing interaction:331-331(MINT-7943431)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P34947	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-7149314|ensembl:ENSP00000376609|intact:MINT-3013589|uniprotkb:D3DRD0|uniprotkb:Q5T059	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:grk5_human(display_long)|uniprotkb:GRK5(gene name)|psi-mi:GRK5(display_short)|uniprotkb:GPRK5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149687|mint:MINT-7943476|imex:IM-14586-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943478(identity)	ensembl:ENSG00000198873(gene)|ensembl:ENST00000392870(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:4TNB|rcsb pdb:4TND|rcsb pdb:6PJX|reactome:R-HSA-416476|reactome:R-HSA-418555|refseq:NP_005299.1|dip:DIP-57457N|mint:MINT-7943482(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	figure legend:f5a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:Wrqm8jdsak0uuhSAvIhfxebfFQc9606	intact-crc:3F42D0693E5FB087|rigid:CamBPDjvU6Mm74B9PLDFQJwGrT0	false	myc tag:?-?(MINT-7943479)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P32121	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149687|mint:MINT-7943476|imex:IM-14586-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943478(identity)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-7943486(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	-	figure legend:f5a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	intact-crc:3F42D0693E5FB087|rigid:CamBPDjvU6Mm74B9PLDFQJwGrT0	false	myc tag:?-?(MINT-7943479)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P49407	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149687|mint:MINT-7943476|imex:IM-14586-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943478(identity)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N|mint:MINT-7943487(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	-	figure legend:f5a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	intact-crc:3F42D0693E5FB087|rigid:CamBPDjvU6Mm74B9PLDFQJwGrT0	false	myc tag:?-?(MINT-7943479)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P34947	uniprotkb:P97288	intact:EBI-7149314|ensembl:ENSP00000376609|intact:MINT-3013589|uniprotkb:D3DRD0|uniprotkb:Q5T059	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	psi-mi:grk5_human(display_long)|uniprotkb:GRK5(gene name)|psi-mi:GRK5(display_short)|uniprotkb:GPRK5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149648|mint:MINT-7943438|imex:IM-14586-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198873(gene)|ensembl:ENST00000392870(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:4TNB|rcsb pdb:4TND|rcsb pdb:6PJX|reactome:R-HSA-416476|reactome:R-HSA-418555|refseq:NP_005299.1|dip:DIP-57457N|mint:MINT-7943450(identity)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943440(identity)	-	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:Wrqm8jdsak0uuhSAvIhfxebfFQc9606	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	intact-crc:A931BA48665361BD|rigid:cKX5geYsKGJAaxgAVp9HJN8b2GY	false	-	mutation disrupting interaction:347-355(MINT-7943453)|mutation disrupting interaction:331-331(MINT-7943443)|myc tag:?-?(MINT-7943447)|mutation disrupting interaction:332-332(MINT-7943441)|mutation disrupting interaction:330-330(MINT-7943445)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49407	uniprotkb:P34947	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	intact:EBI-7149314|ensembl:ENSP00000376609|intact:MINT-3013589|uniprotkb:D3DRD0|uniprotkb:Q5T059	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:grk5_human(display_long)|uniprotkb:GRK5(gene name)|psi-mi:GRK5(display_short)|uniprotkb:GPRK5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149736|mint:MINT-7943519|imex:IM-14586-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N|mint:MINT-7943527(identity)	ensembl:ENSG00000198873(gene)|ensembl:ENST00000392870(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:4TNB|rcsb pdb:4TND|rcsb pdb:6PJX|reactome:R-HSA-416476|reactome:R-HSA-418555|refseq:NP_005299.1|dip:DIP-57457N|mint:MINT-7943525(identity)	-	-	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	figure legend:f7b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	rogid:Wrqm8jdsak0uuhSAvIhfxebfFQc9606	intact-crc:ED2F0B405B6F72D3|rigid:pvwWA5TxJtKQppFr/wcY2zUD5N8	false	yellow fluorescent protein tag:?-?(MINT-7943528)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49407	uniprotkb:P97288	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149736|mint:MINT-7943519|imex:IM-14586-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N|mint:MINT-7943527(identity)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943521(identity)	-	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	figure legend:f7b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	intact-crc:ED2F0B405B6F72D3|rigid:pvwWA5TxJtKQppFr/wcY2zUD5N8	false	yellow fluorescent protein tag:?-?(MINT-7943528)	myc tag:?-?(MINT-7943522)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97288	uniprotkb:P34947	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-7149314|ensembl:ENSP00000376609|intact:MINT-3013589|uniprotkb:D3DRD0|uniprotkb:Q5T059	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:grk5_human(display_long)|uniprotkb:GRK5(gene name)|psi-mi:GRK5(display_short)|uniprotkb:GPRK5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149715|mint:MINT-7943501|imex:IM-14586-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943503(identity)	ensembl:ENSG00000198873(gene)|ensembl:ENST00000392870(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:4TNB|rcsb pdb:4TND|rcsb pdb:6PJX|reactome:R-HSA-416476|reactome:R-HSA-418555|refseq:NP_005299.1|dip:DIP-57457N|mint:MINT-7943507(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:Wrqm8jdsak0uuhSAvIhfxebfFQc9606	intact-crc:018E448248204FB9|rigid:pvwWA5TxJtKQppFr/wcY2zUD5N8	false	myc tag:?-?(MINT-7943504)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P49407	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149715|mint:MINT-7943501|imex:IM-14586-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943503(identity)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N|mint:MINT-7943511(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	intact-crc:018E448248204FB9|rigid:pvwWA5TxJtKQppFr/wcY2zUD5N8	false	myc tag:?-?(MINT-7943504)	yellow fluorescent protein tag:?-?(MINT-7943516)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P34947	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-7149314|ensembl:ENSP00000376609|intact:MINT-3013589|uniprotkb:D3DRD0|uniprotkb:Q5T059	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:grk5_human(display_long)|uniprotkb:GRK5(gene name)|psi-mi:GRK5(display_short)|uniprotkb:GPRK5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149814|mint:MINT-7943553|imex:IM-14586-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943555(identity)	ensembl:ENSG00000198873(gene)|ensembl:ENST00000392870(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:4TNB|rcsb pdb:4TND|rcsb pdb:6PJX|reactome:R-HSA-416476|reactome:R-HSA-418555|refseq:NP_005299.1|dip:DIP-57457N|mint:MINT-7943559(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	figure legend:f9b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:Wrqm8jdsak0uuhSAvIhfxebfFQc9606	intact-crc:CB90EC2C1DA691F3|rigid:H7DU1EjPYMZBdpxf9T8lajfc8so	false	myc tag:?-?(MINT-7943556)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P49407	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149814|mint:MINT-7943553|imex:IM-14586-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943555(identity)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N|mint:MINT-7943561(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	-	figure legend:f9b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	intact-crc:CB90EC2C1DA691F3|rigid:H7DU1EjPYMZBdpxf9T8lajfc8so	false	myc tag:?-?(MINT-7943556)	phosphorylated residue:412-412(MINT-7943562)|flag tag:?-?(MINT-7943567)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P12931	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149814|mint:MINT-7943553|imex:IM-14586-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943555(identity)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N|mint:MINT-7943570(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	-	figure legend:f9b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:CB90EC2C1DA691F3|rigid:H7DU1EjPYMZBdpxf9T8lajfc8so	false	myc tag:?-?(MINT-7943556)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P34947	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-7149314|ensembl:ENSP00000376609|intact:MINT-3013589|uniprotkb:D3DRD0|uniprotkb:Q5T059	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:grk5_human(display_long)|uniprotkb:GRK5(gene name)|psi-mi:GRK5(display_short)|uniprotkb:GPRK5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149757|mint:MINT-7943535|imex:IM-14586-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943537(identity)	ensembl:ENSG00000198873(gene)|ensembl:ENST00000392870(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:4TNB|rcsb pdb:4TND|rcsb pdb:6PJX|reactome:R-HSA-416476|reactome:R-HSA-418555|refseq:NP_005299.1|dip:DIP-57457N|mint:MINT-7943541(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	figure legend:f7c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:Wrqm8jdsak0uuhSAvIhfxebfFQc9606	intact-crc:BD3B164DFBF9F234|rigid:pvwWA5TxJtKQppFr/wcY2zUD5N8	false	myc tag:?-?(MINT-7943538)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P49407	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149757|mint:MINT-7943535|imex:IM-14586-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943537(identity)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N|mint:MINT-7943543(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	-	figure legend:f7c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	intact-crc:BD3B164DFBF9F234|rigid:pvwWA5TxJtKQppFr/wcY2zUD5N8	false	myc tag:?-?(MINT-7943538)	phosphorylated residue:412-412(MINT-7943550)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P34947	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-7149314|ensembl:ENSP00000376609|intact:MINT-3013589|uniprotkb:D3DRD0|uniprotkb:Q5T059	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:grk5_human(display_long)|uniprotkb:GRK5(gene name)|psi-mi:GRK5(display_short)|uniprotkb:GPRK5(gene name synonym)|uniprotkb:G protein-coupled receptor kinase GRK5(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149866|mint:MINT-7943457|imex:IM-14586-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943459(identity)	ensembl:ENSG00000198873(gene)|ensembl:ENST00000392870(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:4TNB|rcsb pdb:4TND|rcsb pdb:6PJX|reactome:R-HSA-416476|reactome:R-HSA-418555|refseq:NP_005299.1|dip:DIP-57457N|mint:MINT-7943471(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	comment:mint|function:Specifically phosphorylates the activated forms of G protein-coupled receptors	figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/28	2014/10/16	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:Wrqm8jdsak0uuhSAvIhfxebfFQc9606	intact-crc:15C11738F3BD14C1|rigid:cKX5geYsKGJAaxgAVp9HJN8b2GY	false	myc tag:?-?(MINT-7943468)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97288	uniprotkb:P05480	intact:EBI-7149283|ensembl:ENSMUSP00000027560|uniprotkb:Q3URB5|intact:UNK-6054454|uniprotkb:O89003|uniprotkb:O89004|uniprotkb:Q9R2A4	intact:EBI-298680|ensembl:ENSMUSP00000029175|ensembl:ENSMUSP00000105157|ensembl:ENSMUSP00000105159|uniprotkb:Q2M4I4|intact:EBI-7361449|intact:MINT-142018|uniprotkb:F8WI90	psi-mi:5ht4r_mouse(display_long)|uniprotkb:Htr4(gene name)|psi-mi:Htr4(display_short)|uniprotkb:Serotonin receptor 4(gene name synonym)	psi-mi:src_mouse(display_long)|uniprotkb:Src(gene name)|psi-mi:Src(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Barthet et al. (2009)	pubmed:19661922|imex:IM-14586|mint:MINT-7943357|doi:10.1038/emboj.2009.215	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7149929|mint:MINT-7943591|imex:IM-14586-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017173328.1|refseq:XP_006525739.1|refseq:XP_006525741.1|refseq:XP_006525743.1|refseq:XP_006525746.1|ensembl:ENSMUSG00000026322(gene)|ensembl:ENSMUST00000027560(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032098"(regulation of appetite)|go:"GO:0045202"(synapse)|go:"GO:0051378"(serotonin binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001520(5-Hydroxytryptamine 4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390666|reactome:R-MMU-418555|refseq:NP_032339.2|mint:MINT-7943593(identity)	go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P05480|rcsb pdb:6F3F|reactome:R-MMU-1227986|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-177929|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-191650|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418885|reactome:R-MMU-430116|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-456926|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-6811558|reactome:R-MMU-69231|reactome:R-MMU-8853659|reactome:R-MMU-8874081|reactome:R-MMU-8934903|reactome:R-MMU-8941858|reactome:R-MMU-9009391|reactome:R-MMU-9603381|ensembl:ENSMUSG00000027646(gene)|ensembl:ENSMUST00000029175(transcript)|ensembl:ENSMUST00000109531(transcript)|ensembl:ENSMUST00000109533(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|refseq:NP_001020566.1|refseq:NP_033297.2|dip:DIP-31071N|mint:MINT-7943605(identity)	-	comment:mint|function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase"	-	figure legend:f9c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2010/06/28	2021/02/11	rogid:e2is7InlHiNl/iUOxEZ01HKSY0g10090	rogid:SY8bQUpE/ni7hRMp4F02ygRsU7Q10090	intact-crc:DB158A006E40325A|rigid:M8ENcAWeAmgwfFa337TXI7geg2k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)