#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O08689	uniprotkb:P19883	intact:EBI-2366774|ensembl:ENSMUSP00000027269	intact:EBI-1571188|uniprotkb:Q9BTH0|ensembl:ENSP00000256759|uniprotkb:B5BU94	psi-mi:gdf8_mouse(display_long)|uniprotkb:Mstn(gene name)|psi-mi:Mstn(display_short)|uniprotkb:Gdf8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:fst_human(display_long)|uniprotkb:Activin-binding protein(gene name synonym)|uniprotkb:FST(gene name)|psi-mi:FST(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Cash et al. (2009)	pubmed:19644449|imex:IM-14580|mint:MINT-7914786|doi:10.1038/emboj.2009.205	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7139984|mint:MINT-7914813|imex:IM-14580-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034964.1|ensembl:ENSMUSG00000026100(gene)|ensembl:ENSMUST00000027269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:3HH2|rcsb pdb:3SEK|rcsb pdb:5JI1|go:"GO:0045662"(negative regulation of myoblast differentiation)|mint:MINT-7914815(identity)	ensembl:ENSG00000134363(gene)|ensembl:ENST00000256759(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0007389"(pattern specification process)|go:"GO:0008585"(female gonad development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0038102"(activin receptor antagonist activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048185"(activin binding)|go:"GO:0051798"(positive regulation of hair follicle development)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR017878|interpro:IPR036058|interpro:IPR036773|rcsb pdb:2P6A|rcsb pdb:3HH2|rcsb pdb:5JHW|reactome:R-HSA-2473224|rcsb pdb:2B0U|refseq:NP_006341.1|refseq:NP_037541.1|mint:MINT-7914816(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f4 f5 f6 f7 t1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/22	2014/10/16	rogid:x/AR38nYKdyVtykd0YgBsV2IXL010090	rogid:+g4SG1U00WzrjZWzOXPDoMP5c/I9606	intact-crc:AC80D031E2713BC6|rigid:/o4rRGVuiLlztXefr0cBOrzlH6s	false	-	binding-associated region:30-317(MINT-7914820)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)