#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97772	uniprotkb:Q9WV18	intact:EBI-396863|uniprotkb:Q6AXG4|uniprotkb:Q9EPV6|ensembl:ENSMUSP00000037255	intact:EBI-770718|uniprotkb:Q6PGJ2|uniprotkb:Q9WU48|uniprotkb:Q9WV15|uniprotkb:Q9WV16|uniprotkb:Q9WV17|ensembl:ENSMUSP00000025338	psi-mi:grm1_mouse(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:gabr1_mouse(display_long)|uniprotkb:Gabbr1(gene name)|psi-mi:Gabbr1(display_short)	psi-mi:"MI:0040"(electron microscopy)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090071|mint:MINT-7905466|imex:IM-14608-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107805.1|refseq:NP_058672.1|refseq:XP_006512612.1|ensembl:ENSMUSG00000019828(gene)|ensembl:ENSMUST00000044306(transcript)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|mint:P97772|reactome:R-MMU-416476|reactome:R-MMU-420499|reactome:R-MMU-6794361|mint:MINT-7905468(identity)	refseq:NP_062312.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1990430"(extracellular matrix protein binding)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002456(GPCR, family 3, gamma-aminobutyric acid receptor, type B1)|interpro:IPR017978|interpro:IPR028082|interpro:IPR035976|mint:Q9WV18|reactome:R-MMU-1296041|reactome:R-MMU-418594|reactome:R-MMU-420499|reactome:R-MMU-977444|reactome:R-MMU-997272|ensembl:ENSMUSG00000024462(gene)|ensembl:ENSMUST00000025338(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0016020"(membrane)|go:"GO:0030673"(axolemma)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|mint:MINT-7905469(identity)	go:"GO:0043197"(dendritic spine)	-	-	figure legend:f1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-purkinje cell)|taxid:10090(Mus musculus)	-	2010/06/15	2014/10/16	rogid:WJAWpEEcB6PLmPlnp8R9/mV+rW410090	rogid:6331lBPycLjqzD0oub7a1jXj80E10090	intact-crc:A3F998FA7B65A875|rigid:NConefcbZRIE3+u/1ii4Y4pUCXQ	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P23385	uniprotkb:P23385	intact:EBI-4410410	intact:EBI-4410410	psi-mi:grm1_rat(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:grm1_rat(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090108|mint:MINT-7905507|imex:IM-14608-6	-	-	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2742|refseq:NP_001107802.1|refseq:NP_058707.1|mint:P23385|dip:DIP-44897N|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1EWK|rcsb pdb:1EWT|rcsb pdb:1EWV|rcsb pdb:1ISR|rcsb pdb:1ISS|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|mint:MINT-7905513(identity)	rgd:2742|refseq:NP_001107802.1|refseq:NP_058707.1|mint:P23385|dip:DIP-44897N|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1EWK|rcsb pdb:1EWT|rcsb pdb:1EWV|rcsb pdb:1ISR|rcsb pdb:1ISS|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|mint:MINT-7905509(identity)	-	-	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:Cy8lKGGALjqGP/e25gw+KqejF5c10116	rogid:Cy8lKGGALjqGP/e25gw+KqejF5c10116	intact-crc:959D020C0DF49ED4|rigid:iFiC9XRvu0M7UT6dDe9SErmYpFg	false	flag tag:?-?(MINT-7905514)	ha tag:?-?(MINT-7905510)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14842	uniprotkb:P31421	intact:EBI-7090176|ensembl:ENSRNOP00000013408|intact:UNK-5372053	intact:EBI-7090147|ensembl:ENSRNOP00000017607|intact:MINT-146442	psi-mi:5ht2a_rat(display_long)|uniprotkb:Htr2a(gene name)|psi-mi:Htr2a(display_short)|uniprotkb:Htr2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:grm2_rat(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090141|mint:MINT-7905522|imex:IM-14608-7	-	-	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010063(gene)|ensembl:ENSRNOT00000013408(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14842|rcsb pdb:4OAJ|reactome:R-RNO-390666|reactome:R-RNO-416476|go:"GO:0070852"(cell body fiber)|refseq:NP_058950.1|rgd:61800|dip:DIP-57661N|mint:MINT-7905524(identity)	ensembl:ENSRNOG00000013171(gene)|ensembl:ENSRNOT00000017607(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31421|reactome:R-RNO-418594|reactome:R-RNO-420499|refseq:XP_017450945.1|refseq:XP_017450946.1|refseq:NP_001099181.1|rgd:2743|dip:DIP-41937N|mint:MINT-7905528(identity)	-	function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production"|comment:mint	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization|comment:mint	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:CUADU4iCEiVm4kTZ+EZ/w9Omy8M10116	rogid:LVjjD/Uvv4io40UWVuFTCMetoxw10116	intact-crc:3CE323FA29F01A93|rigid:jj4k2L0/edZEnDX1Kw2kWgVGVqY	false	ha tag:?-?(MINT-7905525)	flag tag:?-?(MINT-7905529)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z0U4	uniprotkb:O88871	intact:EBI-7090268|intact:UNK-5560925|uniprotkb:Q9Z0F9|uniprotkb:O08620|uniprotkb:O08621|uniprotkb:Q9Z308	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	psi-mi:gabr1_rat(display_long)|uniprotkb:Gabbr1(gene name)|psi-mi:Gabbr1(display_short)	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090318|mint:MINT-7905535|imex:IM-14608-8	-	-	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9Z0U4|refseq:XP_006255941.1|interpro:IPR002456(GPCR, family 3, gamma-aminobutyric acid receptor, type B1)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0016020"(membrane)|go:"GO:0030673"(axolemma)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1990430"(extracellular matrix protein binding)|rcsb pdb:1SRZ|rcsb pdb:1SS2|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|interpro:IPR017978|refseq:NP_112290.2|interpro:IPR000436(Sushi/SCR/CCP)|rgd:621537|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR028082|interpro:IPR035976|mint:MINT-7905537(identity)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7905541(identity)	-	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:homomint|comment:mint|figure legend:f3a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:3x+mBvnwGiR6R8XPKUvTCDovYxM10116	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	intact-crc:FF503E3B30ABC7AB|rigid:O3861JHjgRBPK+39UGnRoXk7yxk	false	ha tag:?-?(MINT-7905538)	flag tag:?-?(MINT-7905542)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10608	uniprotkb:P10608	intact:EBI-7090342|intact:UNK-5371175|uniprotkb:Q6LCR3	intact:EBI-7090342|intact:UNK-5371175|uniprotkb:Q6LCR3	psi-mi:adrb2_rat(display_long)|uniprotkb:Adrb2(gene name)|psi-mi:Adrb2(display_short)|uniprotkb:Adrb2r(gene name synonym)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)	psi-mi:adrb2_rat(display_long)|uniprotkb:Adrb2(gene name)|psi-mi:Adrb2(display_short)|uniprotkb:Adrb2r(gene name synonym)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090336|mint:MINT-7905548|imex:IM-14608-9	-	-	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P10608|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001993"(regulation of systemic arterial blood pressure by norepinephrine-epinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003059"(positive regulation of the force of heart contraction by epinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0005768"(endosome)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031649"(heat generation)|go:"GO:0031713"(B2 bradykinin receptor binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033574"(response to testosterone)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071867"(response to monoamine)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:0097421"(liver regeneration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|reactome:R-RNO-390696|reactome:R-RNO-418555|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|rgd:2060|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:MINT-7905550(identity)	mint:P10608|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001993"(regulation of systemic arterial blood pressure by norepinephrine-epinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003059"(positive regulation of the force of heart contraction by epinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0005768"(endosome)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009409"(response to cold)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031649"(heat generation)|go:"GO:0031713"(B2 bradykinin receptor binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033574"(response to testosterone)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071867"(response to monoamine)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:0097421"(liver regeneration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|reactome:R-RNO-390696|reactome:R-RNO-418555|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|rgd:2060|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:MINT-7905554(identity)	-	comment:mint|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine	comment:mint|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:WuRGvJSKXIPcYN3lgh7/BoOVYLQ10116	rogid:WuRGvJSKXIPcYN3lgh7/BoOVYLQ10116	intact-crc:860E9754ADCEA588|rigid:haT/6COdfpLbyc7F+zsBEGGF66M	false	fusion protein:?-?(MINT-7905551)	flag tag:?-?(MINT-7905555)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14842	uniprotkb:P31421	intact:EBI-7090176|ensembl:ENSRNOP00000013408|intact:UNK-5372053	intact:EBI-7090147|ensembl:ENSRNOP00000017607|intact:MINT-146442	psi-mi:5ht2a_rat(display_long)|uniprotkb:Htr2a(gene name)|psi-mi:Htr2a(display_short)|uniprotkb:Htr2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:grm2_rat(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090437|mint:MINT-7905606|imex:IM-14608-11	-	-	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010063(gene)|ensembl:ENSRNOT00000013408(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14842|rcsb pdb:4OAJ|reactome:R-RNO-390666|reactome:R-RNO-416476|go:"GO:0070852"(cell body fiber)|refseq:NP_058950.1|rgd:61800|dip:DIP-57661N|mint:MINT-7905608(identity)	ensembl:ENSRNOG00000013171(gene)|ensembl:ENSRNOT00000017607(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31421|reactome:R-RNO-418594|reactome:R-RNO-420499|refseq:XP_017450945.1|refseq:XP_017450946.1|refseq:NP_001099181.1|rgd:2743|dip:DIP-41937N|mint:MINT-7905612(identity)	-	function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production"|comment:mint	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization|comment:mint	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:CUADU4iCEiVm4kTZ+EZ/w9Omy8M10116	rogid:LVjjD/Uvv4io40UWVuFTCMetoxw10116	intact-crc:BB37867A53382A21|rigid:jj4k2L0/edZEnDX1Kw2kWgVGVqY	false	fusion protein:?-?(MINT-7905609)	flag tag:?-?(MINT-7905613)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88871	uniprotkb:Q9Z0U4	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	intact:EBI-7090268|intact:UNK-5560925|uniprotkb:Q9Z0F9|uniprotkb:O08620|uniprotkb:O08621|uniprotkb:Q9Z308	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:gabr1_rat(display_long)|uniprotkb:Gabbr1(gene name)|psi-mi:Gabbr1(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090419|mint:MINT-7905578|imex:IM-14608-10	-	-	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7905584(identity)	mint:Q9Z0U4|refseq:XP_006255941.1|interpro:IPR002456(GPCR, family 3, gamma-aminobutyric acid receptor, type B1)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0016020"(membrane)|go:"GO:0030673"(axolemma)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1990430"(extracellular matrix protein binding)|rcsb pdb:1SRZ|rcsb pdb:1SS2|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|interpro:IPR017978|refseq:NP_112290.2|interpro:IPR000436(Sushi/SCR/CCP)|rgd:621537|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR028082|interpro:IPR035976|mint:MINT-7905580(identity)	-	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	rogid:3x+mBvnwGiR6R8XPKUvTCDovYxM10116	intact-crc:D454233A20BBF2B2|rigid:O3861JHjgRBPK+39UGnRoXk7yxk	false	flag tag:?-?(MINT-7905585)	fusion protein:?-?(MINT-7905581)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z0U4	uniprotkb:O88871	intact:EBI-7090268|intact:UNK-5560925|uniprotkb:Q9Z0F9|uniprotkb:O08620|uniprotkb:O08621|uniprotkb:Q9Z308	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	psi-mi:gabr1_rat(display_long)|uniprotkb:Gabbr1(gene name)|psi-mi:Gabbr1(display_short)	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090479|mint:MINT-7905462|imex:IM-14608-5	-	-	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9Z0U4|refseq:XP_006255941.1|interpro:IPR002456(GPCR, family 3, gamma-aminobutyric acid receptor, type B1)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0016020"(membrane)|go:"GO:0030673"(axolemma)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1990430"(extracellular matrix protein binding)|rcsb pdb:1SRZ|rcsb pdb:1SS2|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|interpro:IPR017978|refseq:NP_112290.2|interpro:IPR000436(Sushi/SCR/CCP)|rgd:621537|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR028082|interpro:IPR035976|mint:MINT-7905464(identity)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7905465(identity)	-	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	figure legend:f4a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:3x+mBvnwGiR6R8XPKUvTCDovYxM10116	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	intact-crc:DB1F6529380B9CCA|rigid:O3861JHjgRBPK+39UGnRoXk7yxk	false	yellow fluorescent protein tag:?-?(MINT-7905477)	fusion protein:?-?(MINT-7905481)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23385	uniprotkb:P23385	intact:EBI-4410410	intact:EBI-4410410	psi-mi:grm1_rat(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:grm1_rat(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090497|mint:MINT-7905489|imex:IM-14608-4	-	-	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0579"(electron donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2742|refseq:NP_001107802.1|refseq:NP_058707.1|mint:P23385|dip:DIP-44897N|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1EWK|rcsb pdb:1EWT|rcsb pdb:1EWV|rcsb pdb:1ISR|rcsb pdb:1ISS|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|mint:MINT-7905495(identity)	rgd:2742|refseq:NP_001107802.1|refseq:NP_058707.1|mint:P23385|dip:DIP-44897N|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1EWK|rcsb pdb:1EWT|rcsb pdb:1EWV|rcsb pdb:1ISR|rcsb pdb:1ISS|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|mint:MINT-7905491(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:Cy8lKGGALjqGP/e25gw+KqejF5c10116	rogid:Cy8lKGGALjqGP/e25gw+KqejF5c10116	intact-crc:3A5999CBD65345BC|rigid:iFiC9XRvu0M7UT6dDe9SErmYpFg	false	yellow fluorescent protein tag:?-?(MINT-7905496)	fusion protein:?-?(MINT-7905492)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14842	uniprotkb:P31421	intact:EBI-7090176|ensembl:ENSRNOP00000013408|intact:UNK-5372053	intact:EBI-7090147|ensembl:ENSRNOP00000017607|intact:MINT-146442	psi-mi:5ht2a_rat(display_long)|uniprotkb:Htr2a(gene name)|psi-mi:Htr2a(display_short)|uniprotkb:Htr2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:grm2_rat(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090828|mint:MINT-7905622|imex:IM-14608-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010063(gene)|ensembl:ENSRNOT00000013408(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14842|rcsb pdb:4OAJ|reactome:R-RNO-390666|reactome:R-RNO-416476|go:"GO:0070852"(cell body fiber)|refseq:NP_058950.1|rgd:61800|dip:DIP-57661N|mint:MINT-7905624(identity)	ensembl:ENSRNOG00000013171(gene)|ensembl:ENSRNOT00000017607(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31421|reactome:R-RNO-418594|reactome:R-RNO-420499|refseq:XP_017450945.1|refseq:XP_017450946.1|refseq:NP_001099181.1|rgd:2743|dip:DIP-41937N|mint:MINT-7905628(identity)	-	function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production"|comment:mint	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization|comment:mint	figure legend:f5|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:CUADU4iCEiVm4kTZ+EZ/w9Omy8M10116	rogid:LVjjD/Uvv4io40UWVuFTCMetoxw10116	intact-crc:806B7E19FA48E72A|rigid:jj4k2L0/edZEnDX1Kw2kWgVGVqY	false	ha tag:?-?(MINT-7905625)	flag tag:?-?(MINT-7905629)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z0U4	uniprotkb:O88871	intact:EBI-7090268|intact:UNK-5560925|uniprotkb:Q9Z0F9|uniprotkb:O08620|uniprotkb:O08621|uniprotkb:Q9Z308	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	psi-mi:gabr1_rat(display_long)|uniprotkb:Gabbr1(gene name)|psi-mi:Gabbr1(display_short)	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090864|mint:MINT-7905653|imex:IM-14608-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9Z0U4|refseq:XP_006255941.1|interpro:IPR002456(GPCR, family 3, gamma-aminobutyric acid receptor, type B1)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0016020"(membrane)|go:"GO:0030673"(axolemma)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1990430"(extracellular matrix protein binding)|rcsb pdb:1SRZ|rcsb pdb:1SS2|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|interpro:IPR017978|refseq:NP_112290.2|interpro:IPR000436(Sushi/SCR/CCP)|rgd:621537|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR028082|interpro:IPR035976|mint:MINT-7905655(identity)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7905659(identity)	-	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	figure legend:f5|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:3x+mBvnwGiR6R8XPKUvTCDovYxM10116	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	intact-crc:BAEA27A6472CFBE6|rigid:O3861JHjgRBPK+39UGnRoXk7yxk	false	flag tag:?-?(MINT-7905656)	ha tag:?-?(MINT-7905660)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O88871	uniprotkb:Q9Z0U4	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	intact:EBI-7090268|intact:UNK-5560925|uniprotkb:Q9Z0F9|uniprotkb:O08620|uniprotkb:O08621|uniprotkb:Q9Z308	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:gabr1_rat(display_long)|uniprotkb:Gabbr1(gene name)|psi-mi:Gabbr1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rives et al. (2009)	pubmed:19590495|imex:IM-14608|mint:MINT-7905450|doi:10.1038/emboj.2009.177	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7090846|mint:MINT-7905636|imex:IM-14608-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7905642(identity)	mint:Q9Z0U4|refseq:XP_006255941.1|interpro:IPR002456(GPCR, family 3, gamma-aminobutyric acid receptor, type B1)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0016020"(membrane)|go:"GO:0030673"(axolemma)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1990430"(extracellular matrix protein binding)|rcsb pdb:1SRZ|rcsb pdb:1SS2|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|interpro:IPR017978|refseq:NP_112290.2|interpro:IPR000436(Sushi/SCR/CCP)|rgd:621537|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR028082|interpro:IPR035976|mint:MINT-7905638(identity)	-	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	figure legend:f5|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/06/15	2014/10/16	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	rogid:3x+mBvnwGiR6R8XPKUvTCDovYxM10116	intact-crc:B41CC73C83597A4D|rigid:O3861JHjgRBPK+39UGnRoXk7yxk	false	flag tag:?-?(MINT-7905643)	ha tag:?-?(MINT-7905639)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0707"(anti tag immunostaining)