#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P04177 uniprotkb:P63102 intact:EBI-7507216|intact:MINT-4585867|ensembl:ENSRNOP00000027682 intact:EBI-354758|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q52KK1|uniprotkb:Q6IRF4|ensembl:ENSRNOP00000030885 psi-mi:ty3h_rat(display_long)|uniprotkb:Th(gene name)|psi-mi:Th(display_short)|uniprotkb:Tyrosine 3-hydroxylase(gene name synonym) psi-mi:1433z_rat(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Msfs1(gene name synonym)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Mitochondrial import stimulation factor S1 subunit(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Wang et al. (2009) mint:MINT-8008846|pubmed:19289463|doi:10.1074/jbc.M901310200 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8595319|mint:MINT-8008854 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0019899"(enzyme binding)|refseq:NP_036872.1|rgd:3853|ensembl:ENSRNOT00000027682(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0004511"(tyrosine 3-monooxygenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006585"(dopamine biosynthetic process from tyrosine)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009414"(response to water deprivation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009635"(response to herbicide)|go:"GO:0009651"(response to salt stress)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010038"(response to metal ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015842"(aminergic neurotransmitter loading into synaptic vesicle)|go:"GO:0016137"(glycoside metabolic process)|go:"GO:0016597"(amino acid binding)|go:"GO:0017085"(response to insecticide)|go:"GO:0018963"(phthalate metabolic process)|go:"GO:0019825"(oxygen binding)|ensembl:ENSRNOG00000020410(gene)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0045472"(response to ether)|go:"GO:0046684"(response to pyrethroid)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0052314"(phytoalexin metabolic process)|go:"GO:0070848"(response to growth factor)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071316"(cellular response to nicotine)|rcsb pdb:2MDA|rcsb pdb:2TOH|reactome:R-RNO-209905|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR001273(Aromatic amino acid hydroxylase)|interpro:IPR005962(Tyrosine 3-monooxygenase)|interpro:IPR018301|interpro:IPR019773|interpro:IPR019774|interpro:IPR021164|interpro:IPR036329|interpro:IPR036951|interpro:IPR041903|mint:P04177|rcsb pdb:1TOH|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033076"(isoquinoline alkaloid metabolic process)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0035690"|go:"GO:0035900"(response to isolation stress)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042214"(terpene metabolic process)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042418"(epinephrine biosynthetic process)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0042423"(catecholamine biosynthetic process)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042493"|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0019904"(protein domain specific binding)|mint:MINT-8008858(identity)|uniprotkb:P04177(original identifier) rgd:3980|refseq:NP_037143.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63102|reactome:R-RNO-111447|reactome:R-RNO-3769402|reactome:R-RNO-392517|reactome:R-RNO-430116|reactome:R-RNO-450604|reactome:R-RNO-512988|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-9013700|reactome:R-RNO-9614399|refseq:XP_006241591.1|ensembl:ENSRNOG00000008195(gene)|ensembl:ENSRNOT00000035628(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|dip:DIP-36916N|mint:MINT-8008855(identity)|uniprotkb:P63102(original identifier) - comment:mint|comment:homomint|function:Plays an important role in the physiology of adrenergic neurons - comment:domino|comment:mint taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/21 2014/10/16 rogid:1tnfhRp4xKaRGRYGgD51S0dLmpU10116 rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10116 intact-crc:56026734A29B0BB6|rigid:I5jlafbB9+1D+9JIuvg0phu62hM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)