#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8TAC9	uniprotkb:Q9UNK0	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	intact:EBI-727240|uniprotkb:O60712|uniprotkb:Q53XT8|ensembl:ENSP00000305255	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:stx8_human(display_long)|uniprotkb:STX8(gene name)|psi-mi:STX8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695793|imex:IM-20480-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	refseq:NP_004844.1|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR041875|mint:Q9UNK0|ensembl:ENSG00000170310(gene)|ensembl:ENST00000306357(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|dip:DIP-47274N	-	-	-	figure legend:Fig 7A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2010/06/07	2014/10/16	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	rogid:jdsUOdy99aWRb94ndPtawff7z/o9606	intact-crc:3CA7C404FFC2EC05|rigid:O5bYzroLV2YLqD3TRoJVi82nVao	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TAC9	uniprotkb:O43752	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	intact:EBI-2695795|uniprotkb:Q5VY08|uniprotkb:B2R652|uniprotkb:Q6FH83|intact:EBI-28977663|ensembl:ENSP00000258301|uniprotkb:B4DR17	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:stx6_human(display_long)|uniprotkb:STX6(gene name)|psi-mi:STX6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695793|imex:IM-20480-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	ensembl:ENSP00000258301|ensembl:ENST00000542060|ensembl:ENSP00000440188|refseq:NP_005810.1|ensembl:ENSG00000135823(gene)|ensembl:ENST00000258301(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:O43752|rcsb pdb:2NPS|rcsb pdb:4J2C|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001273139.1|refseq:XP_016855496.1|dip:DIP-44224N	-	-	-	figure legend:Fig 7A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2010/06/07	2014/10/16	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	rogid:g8/HcXvvEY2Pqv8NWy3V+T+jBTY9606	intact-crc:3CA7C404FFC2EC05|rigid:O5bYzroLV2YLqD3TRoJVi82nVao	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TAC9	uniprotkb:Q12846	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	intact:EBI-744942|uniprotkb:Q15525|ensembl:ENSP00000317714|uniprotkb:Q6FHE8|uniprotkb:A8MXY0	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:stx4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-31(gene name synonym)|uniprotkb:STX4(gene name)|psi-mi:STX4(display_short)|uniprotkb:STX4A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695793|imex:IM-20480-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	ensembl:ENSG00000103496(gene)|refseq:NP_004595.2|ensembl:ENST00000313843(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016230"(sphingomyelin phosphodiesterase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042581"(specific granule)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043219"(lateral loop)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048278"(vesicle docking)|go:"GO:0048284"(organelle fusion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|reactome:R-HSA-114516|reactome:R-HSA-1236974|reactome:R-HSA-1445148|reactome:R-HSA-199992|reactome:R-HSA-449836|interpro:IPR006011(Syntaxin, N-terminal)|refseq:NP_001259025.1	-	-	-	figure legend:Fig 7A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2010/06/07	2014/10/16	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	rogid:NvOLGIGe/XO2aDPSpdPzrtKniZY9606	intact-crc:3CA7C404FFC2EC05|rigid:O5bYzroLV2YLqD3TRoJVi82nVao	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TAC9	uniprotkb:O75379	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	intact:EBI-744953|uniprotkb:Q96IY9|uniprotkb:Q96J20|uniprotkb:Q9UEL7|uniprotkb:A2IDD8|ensembl:ENSP00000236192|ensembl:ENSP00000435933	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:vamp4_human(display_long)|uniprotkb:VAMP4(gene name)|psi-mi:VAMP4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695793|imex:IM-20480-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	refseq:NP_001172056.1|refseq:NP_003753.2|ensembl:ENSG00000117533(gene)|ensembl:ENST00000236192(transcript)|ensembl:ENST00000474047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030133"(transport vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|interpro:IPR042887|mint:O75379|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-44226N	-	-	-	figure legend:Fig 7A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2010/06/07	2014/10/16	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	rogid:tITvmst+UYk596iJSowMT+R0U/89606	intact-crc:3CA7C404FFC2EC05|rigid:O5bYzroLV2YLqD3TRoJVi82nVao	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TAC9	uniprotkb:O00161	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	intact:EBI-745000|uniprotkb:O00162|uniprotkb:Q13602|uniprotkb:Q6IAE3|ensembl:ENSP00000249647	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:snp23_human(display_long)|uniprotkb:Vesicle-membrane fusion protein SNAP-23(gene name synonym)|uniprotkb:SNAP23(gene name)|psi-mi:SNAP23(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695793|imex:IM-20480-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	refseq:NP_003816.2|refseq:NP_570710.1|ensembl:ENSG00000092531(gene)|ensembl:ENST00000249647(transcript)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043005"(neuron projection)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|mint:O00161|rcsb pdb:1NHL|rcsb pdb:3ZUS|reactome:R-HSA-1445148|reactome:R-HSA-199992|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-1236974	-	-	-	figure legend:Fig 7A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2010/06/07	2014/10/16	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	rogid:8ZcXbqhusSijGdekDMdkZA5DejY9606	intact-crc:3CA7C404FFC2EC05|rigid:O5bYzroLV2YLqD3TRoJVi82nVao	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TAC9	uniprotkb:Q15836	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	intact:EBI-722343|uniprotkb:Q9BRV4|ensembl:ENSP00000054666	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:vamp3_human(display_long)|uniprotkb:Synaptobrevin-3(gene name synonym)|uniprotkb:Cellubrevin(gene name synonym)|uniprotkb:VAMP3(gene name)|psi-mi:VAMP3(display_short)|uniprotkb:SYB3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695793|imex:IM-20480-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	refseq:NP_004772.1|dip:DIP-56422N|ensembl:ENSG00000049245(gene)|ensembl:ENST00000054666(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1903531"(negative regulation of secretion by cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q15836|reactome:R-HSA-1236974|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034	-	-	-	figure legend:Fig 7A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2010/06/07	2014/10/16	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	rogid:JeCaIwh36OpRqMG0MFnpFZyN6jU9606	intact-crc:3CA7C404FFC2EC05|rigid:O5bYzroLV2YLqD3TRoJVi82nVao	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TAC9	uniprotkb:P46096	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	intact:EBI-445340|ensembl:ENSMUSP00000063293|ensembl:ENSMUSP00000100912	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:syt1_mouse(display_long)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)	psi-mi:"MI:0096"(pull down)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695818|imex:IM-20480-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	refseq:NP_001239271.1|refseq:NP_033332.1|refseq:XP_006513509.1|refseq:XP_006513510.1|refseq:XP_006513511.1|refseq:NP_001239270.1|ensembl:ENSMUSG00000035864(gene)|ensembl:ENSMUST00000064054(transcript)|ensembl:ENSMUST00000105276(transcript)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0000149"(SNARE binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|refseq:XP_017169355.1|go:"GO:0060076"(excitatory synapse)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071911"(synchronous neurotransmitter secretion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098746"(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P46096|rcsb pdb:5T0R|rcsb pdb:5T0S|rcsb pdb:5VFE|rcsb pdb:5VFF|rcsb pdb:5VFG|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-888590|dip:DIP-31322N	-	-	-	figure legend:Fig 7B|agonist:Lipopolysaccharide|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/07	2014/10/16	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	rogid:CxQGrKu3l0pEzQ3aJZBJ/GZMyEA10090	intact-crc:D0262959C9E2F26C|rigid:2I17hCx+RUymOlyJ15ZJwjrhBNs	false	glutathione s tranferase tag:n-n|necessary binding region:172-235	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8TAC9	uniprotkb:P46097	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	intact:EBI-457969|uniprotkb:Q8R0E1	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:syt2_mouse(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Inositol polyphosphate-binding protein(gene name synonym)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695818|imex:IM-20480-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	refseq:NP_033333.2|refseq:XP_006529385.1|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NP0|rcsb pdb:4KBB|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|dip:DIP-32645N|mint:P46097|refseq:XP_006529386.1	-	-	-	figure legend:Fig 7B|agonist:Lipopolysaccharide|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/07	2014/10/16	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	rogid:rGZ9RcldKTata4wFKxyBGR3sDOc10090	intact-crc:D0262959C9E2F26C|rigid:2I17hCx+RUymOlyJ15ZJwjrhBNs	false	glutathione s tranferase tag:n-n|necessary binding region:172-235	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46096	uniprotkb:Q8TAC9	intact:EBI-445340|ensembl:ENSMUSP00000063293|ensembl:ENSMUSP00000100912	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	psi-mi:syt1_mouse(display_long)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695850|imex:IM-20480-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001239271.1|refseq:NP_033332.1|refseq:XP_006513509.1|refseq:XP_006513510.1|refseq:XP_006513511.1|refseq:NP_001239270.1|ensembl:ENSMUSG00000035864(gene)|ensembl:ENSMUST00000064054(transcript)|ensembl:ENSMUST00000105276(transcript)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0000149"(SNARE binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|refseq:XP_017169355.1|go:"GO:0060076"(excitatory synapse)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071911"(synchronous neurotransmitter secretion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098746"(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P46096|rcsb pdb:5T0R|rcsb pdb:5T0S|rcsb pdb:5VFE|rcsb pdb:5VFF|rcsb pdb:5VFG|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-888590|dip:DIP-31322N	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	-	-	-	figure legend:Fig 7D|agonist:Ionomycin|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2010/06/07	2014/10/16	rogid:CxQGrKu3l0pEzQ3aJZBJ/GZMyEA10090	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	intact-crc:AB401CD1471E0264|rigid:yXY9F0xGlfs5RMtQOs2xwsQ2ZN8	false	-	flag tag:?-?|necessary binding region:171-235	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P46097	uniprotkb:Q8TAC9	intact:EBI-457969|uniprotkb:Q8R0E1	intact:EBI-2695784|uniprotkb:B3KPJ7|uniprotkb:B7Z762|uniprotkb:Q8N3M4|uniprotkb:D3DW71|ensembl:ENSP00000355387|ensembl:ENSP00000406547	psi-mi:syt2_mouse(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Inositol polyphosphate-binding protein(gene name synonym)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:scam5_human(display_long)|uniprotkb:SCAMP5(gene name)|psi-mi:SCAMP5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chaofeng et al. (2009)	pubmed:19234194|imex:IM-20480	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2695855|imex:IM-20480-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033333.2|refseq:XP_006529385.1|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NP0|rcsb pdb:4KBB|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|dip:DIP-32645N|mint:P46097|refseq:XP_006529386.1	refseq:NP_620417.1|refseq:NP_001171582.1|refseq:NP_001171583.1|ensembl:ENST00000361900(transcript)|ensembl:ENST00000425597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR007273(SCAMP)|mint:Q8TAC9|ensembl:ENSG00000198794(gene)|refseq:XP_006720484.1|refseq:XP_006720485.1|refseq:XP_016877478.1	-	-	-	figure legend:Fig 7D|agonist:Ionomycin|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2010/06/07	2014/10/16	rogid:rGZ9RcldKTata4wFKxyBGR3sDOc10090	rogid:y/GbIvGM/tI68mfdQnMahowFPA49606	intact-crc:054BDC702DDED314|rigid:wnQB10t51S0PmycIErO20PC72GY	false	-	necessary binding region:171-235|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)