#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29067	uniprotkb:P08172	intact:EBI-1636616|ensembl:ENSRNOP00000026207	intact:EBI-2624832|uniprotkb:Q4VBK6|uniprotkb:Q9P1X9|ensembl:ENSP00000319984|ensembl:ENSP00000384401|ensembl:ENSP00000399745|ensembl:ENSP00000415386|ensembl:ENSP00000505686	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:acm2_human(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Mosser et al. (2008)	pubmed:19055777|imex:IM-20506	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-2908638|imex:IM-20506-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	refseq:XP_011514071.1|refseq:NP_000730.1|refseq:NP_001006627.1|refseq:NP_001006628.1|refseq:NP_001006629.1|refseq:NP_001006630.1|refseq:NP_001006631.1|refseq:NP_001006632.1|refseq:NP_001006633.1|ensembl:ENSG00000181072(gene)|ensembl:ENST00000320658(transcript)|ensembl:ENST00000401861(transcript)|ensembl:ENST00000445907(transcript)|ensembl:ENST00000453373(transcript)|ensembl:ENST00000680005(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LUB|rcsb pdb:3UON|rcsb pdb:4MQS|rcsb pdb:4MQT|rcsb pdb:5YC8|rcsb pdb:5ZK3|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|rcsb pdb:5ZKB|rcsb pdb:5ZKC|rcsb pdb:6OIK|rcsb pdb:6U1N|reactome:R-HSA-390648|reactome:R-HSA-418594|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:5ZK8|dip:DIP-56282N	-	-	-	figure legend:fig.9|agonist:carbachol|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2010/08/17	2014/10/16	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rogid:Rg7s3/iAh4+DTvkasK8G/BWc+yM9606	intact-crc:BEDD55EA0C28055B|rigid:b0eOmTTgiMir0+/pplmP7wkv6pA	false	flag tag:?-?|mutation decreasing interaction:18-18,107-107,207-207,108-108,296-296	ha tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P11438	uniprotkb:P08172	intact:EBI-987439|uniprotkb:Q62020|ensembl:ENSMUSP00000033824	intact:EBI-2624832|uniprotkb:Q4VBK6|uniprotkb:Q9P1X9|ensembl:ENSP00000319984|ensembl:ENSP00000384401|ensembl:ENSP00000399745|ensembl:ENSP00000415386|ensembl:ENSP00000505686	psi-mi:lamp1_mouse(display_long)|uniprotkb:Lysosomal membrane glycoprotein A(gene name synonym)|uniprotkb:120 kDa lysosomal membrane glycoprotein(gene name synonym)|uniprotkb:LGP-120(gene name synonym)|uniprotkb:P2B(gene name synonym)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:Lamp1(gene name)|psi-mi:Lamp1(display_short)|uniprotkb:Lamp-1(gene name synonym)	psi-mi:acm2_human(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Mosser et al. (2008)	pubmed:19055777|imex:IM-20506	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-2908661|imex:IM-20506-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031447(gene)|ensembl:ENSMUST00000033824(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|refseq:NP_034814.2|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044194"(cytolytic granule)|go:"GO:0044754"(autolysosome)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0005829"(cytosol)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11438|rcsb pdb:5GV0|reactome:R-MMU-6798695|refseq:NP_001304282.1	refseq:XP_011514071.1|refseq:NP_000730.1|refseq:NP_001006627.1|refseq:NP_001006628.1|refseq:NP_001006629.1|refseq:NP_001006630.1|refseq:NP_001006631.1|refseq:NP_001006632.1|refseq:NP_001006633.1|ensembl:ENSG00000181072(gene)|ensembl:ENST00000320658(transcript)|ensembl:ENST00000401861(transcript)|ensembl:ENST00000445907(transcript)|ensembl:ENST00000453373(transcript)|ensembl:ENST00000680005(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LUB|rcsb pdb:3UON|rcsb pdb:4MQS|rcsb pdb:4MQT|rcsb pdb:5YC8|rcsb pdb:5ZK3|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|rcsb pdb:5ZKB|rcsb pdb:5ZKC|rcsb pdb:6OIK|rcsb pdb:6U1N|reactome:R-HSA-390648|reactome:R-HSA-418594|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:5ZK8|dip:DIP-56282N	-	-	-	figure legend:fig.11|agonist:carbachol|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2010/08/17	2014/10/16	rogid:34kBKJCpWncY9gLqL2lEx3Yn01I10090	rogid:Rg7s3/iAh4+DTvkasK8G/BWc+yM9606	intact-crc:86FE4CDE9BD7ADD7|rigid:okphvS/gKU0k0+P3SbYAdCfNAvE	false	-	ha tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)