#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P63102 uniprotkb:P10636 intact:EBI-354758|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q52KK1|uniprotkb:Q6IRF4|ensembl:ENSRNOP00000030885 intact:EBI-366182|uniprotkb:P18518|uniprotkb:Q14799|uniprotkb:Q15549|uniprotkb:Q15550|uniprotkb:Q15551|uniprotkb:Q1RMF6|uniprotkb:Q53YB1|uniprotkb:Q5CZI7|uniprotkb:Q5XWF0|uniprotkb:Q6QT54|uniprotkb:Q9UDJ3|uniprotkb:Q9UMH0|uniprotkb:Q9UQ96|ensembl:ENSP00000458742 psi-mi:1433z_rat(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Msfs1(gene name synonym)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Mitochondrial import stimulation factor S1 subunit(gene name synonym) psi-mi:tau_human(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:MAPTL(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Sadik et al. (2009) pubmed:19014373|mint:MINT-8008693|doi:10.1111/j.1471-4159.2008.05716 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8499194|mint:MINT-8008702 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3980|refseq:NP_037143.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63102|reactome:R-RNO-111447|reactome:R-RNO-3769402|reactome:R-RNO-392517|reactome:R-RNO-430116|reactome:R-RNO-450604|reactome:R-RNO-512988|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-9013700|reactome:R-RNO-9614399|refseq:XP_006241591.1|ensembl:ENSRNOG00000008195(gene)|ensembl:ENSRNOT00000035628(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|dip:DIP-36916N|mint:MINT-8008703(identity)|uniprotkb:P63102(original identifier) refseq:NP_001116538.2|refseq:NP_001116539.1|refseq:NP_001190181.1|refseq:NP_005901.2|refseq:NP_058518.1|refseq:NP_058519.3|refseq:NP_058525.1|ensembl:ENSG00000186868(gene)|ensembl:ENST00000571987(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001774"(microglial cell activation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016072"(rRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034452"(dynactin binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044297"(cell body)|go:"GO:0044304"(main axon)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048699"(generation of neurons)|go:"GO:0050808"(synapse organization)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051721"(protein phosphatase 2A binding)|rcsb pdb:4GLR|rcsb pdb:4NP8|rcsb pdb:4TQE|rcsb pdb:4Y32|rcsb pdb:4Y3B|rcsb pdb:4Y5I|rcsb pdb:5DMG|rcsb pdb:5E2V|rcsb pdb:5E2W|rcsb pdb:5HF3|rcsb pdb:5K7N|rcsb pdb:5MO3|rcsb pdb:5MP1|rcsb pdb:5MP3|rcsb pdb:5MP5|rcsb pdb:5N5A|rcsb pdb:5N5B|rcsb pdb:5NVB|rcsb pdb:5O3L|rcsb pdb:5O3O|rcsb pdb:5O3T|rcsb pdb:5V5B|rcsb pdb:5V5C|rcsb pdb:5ZIA|rcsb pdb:5ZV3|rcsb pdb:6BB4|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4FL5|rcsb pdb:6DC8|rcsb pdb:6DC9|rcsb pdb:6DCA|rcsb pdb:6FBW|rcsb pdb:6FI5|rcsb pdb:6GK7|rcsb pdb:6GK8|rcsb pdb:6GX5|rcsb pdb:6H06|rcsb pdb:6HRE|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902988"(neurofibrillary tangle assembly)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1905689"(positive regulation of diacylglycerol kinase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR002955(Tau protein)|mint:P10636|rcsb pdb:1I8H|rcsb pdb:2MZ7|rcsb pdb:2ON9|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:3OVL|rcsb pdb:4E0M|rcsb pdb:4E0N|rcsb pdb:4E0O|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0072386"(plus-end-directed organelle transport along microtubule)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097386"(glial cell projection)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098930"(axonal transport)|go:"GO:0099077"(histone-dependent DNA binding)|go:"GO:0099609"(microtubule lateral binding)|rcsb pdb:6HRF|rcsb pdb:6LRA|rcsb pdb:6N4P|rcsb pdb:6NK4|rcsb pdb:6NWP|rcsb pdb:6NWQ|rcsb pdb:6ODG|rcsb pdb:6PXR|rcsb pdb:6QJH|rcsb pdb:6QJM|rcsb pdb:6QJP|rcsb pdb:6QJQ|rcsb pdb:6TJO|rcsb pdb:6TJX|rcsb pdb:6VH7|rcsb pdb:6VHA|rcsb pdb:6VHL|rcsb pdb:6VI3|rcsb pdb:6XLI|rcsb pdb:7NRQ|rcsb pdb:7NRS|rcsb pdb:7NRT|rcsb pdb:7NRV|rcsb pdb:7NRX|reactome:R-HSA-264870|reactome:R-HSA-9619483|dip:DIP-29753N|mint:MINT-8008706(identity)|uniprotkb:P10636(original identifier) - - - comment:domino|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/21 2014/10/16 rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10116 rogid:aAV+Xebz92GY+wGOCRnhBztR5vM9606 intact-crc:B03B7CF06C767966|rigid:ma/TuOLua+fG9S1YM4u8oRN7u/M false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)