#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35968	uniprotkb:P12931	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bhattacharya et al. (2008)	pubmed:18662404|imex:IM-20499	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-2903077|imex:IM-20499-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	-	-	-	figure legend:fig 2|agonist:VEGF|antagonist:dopamine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2010/08/06	2014/10/16	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	intact-crc:4C6C050B4D6AF797|rigid:BnXj5PWIWEuIslwFt5d7ZQGSeb0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16625	uniprotkb:Q07157	intact:EBI-2903088|ensembl:ENSP00000347379|ensembl:ENSP00000379719|ensembl:ENSP00000505426|ensembl:ENSP00000505541|ensembl:ENSP00000506162|uniprotkb:B5BU70|uniprotkb:Q8N6K1|uniprotkb:D2DU64|uniprotkb:D2DU65|uniprotkb:D2IGC0|uniprotkb:D2IGC1|uniprotkb:E2CYV9|uniprotkb:Q5U1V4	intact:EBI-79553|uniprotkb:B4E3K1|ensembl:ENSP00000281537|ensembl:ENSP00000484535|uniprotkb:Q2NKP3|uniprotkb:Q4ZGJ6	psi-mi:ocln_human(display_long)|uniprotkb:OCLN(gene name)|psi-mi:OCLN(display_short)	psi-mi:zo1_human(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bhattacharya et al. (2008)	pubmed:18662404|imex:IM-20499	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-2903109|imex:IM-20499-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192183.1|refseq:NP_001192184.1|refseq:NP_002529.1|rcsb pdb:1WPA|rcsb pdb:1XAW|rcsb pdb:3G7C|reactome:R-HSA-351906|reactome:R-HSA-8935964|ensembl:ENSG00000197822(gene)|ensembl:ENST00000355237(transcript)|ensembl:ENST00000396442(transcript)|ensembl:ENST00000680027(transcript)|ensembl:ENST00000681041(transcript)|ensembl:ENST00000681586(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070160"(tight junction)|go:"GO:0070673"(response to interleukin-18)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1902463"(protein localization to cell leading edge)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR002958(Occludin)|interpro:IPR008253(Marvel)|interpro:IPR010844(Occludin and RNA polymerase II elongation factor ELL)|interpro:IPR031176|interpro:IPR036259|refseq:XP_016864403.1|refseq:XP_016864402.1|dip:DIP-42791N	ensembl:ENSG00000104067(gene)|ensembl:ENSG00000277401(gene)|ensembl:ENST00000346128(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENST00000621049(transcript)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR035597|interpro:IPR036034|mint:Q07157|rcsb pdb:2H2B|rcsb pdb:2H2C|rcsb pdb:2H3M|rcsb pdb:2JWE|rcsb pdb:2KXR|rcsb pdb:2KXS|rcsb pdb:2RCZ|rcsb pdb:3CYY|rcsb pdb:3LH5|rcsb pdb:3SHU|rcsb pdb:3SHW|rcsb pdb:3TSV|rcsb pdb:3TSW|rcsb pdb:3TSZ|rcsb pdb:4OEO|rcsb pdb:4OEP|rcsb pdb:4Q2Q|rcsb pdb:4YYX|reactome:R-HSA-191650|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8935964|refseq:NP_003248.3|refseq:NP_783297.2	-	-	-	figure legend:fig 5|agonist:VEGF|antagonist:dopamine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2010/08/06	2014/10/16	rogid:RyZ9uIVH0TdDwlIFaGJJYbuHvmY9606	rogid:/Yi7U3TcH6kPu4A/bQ5Nj0QeU2w9606	intact-crc:CF3F06DA0CE91B43|rigid:ZGZ2aM/4iOJru3FkjbJYHtfUXME	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33151	uniprotkb:P35222	intact:EBI-2903122|ensembl:ENSP00000344115|ensembl:ENSP00000497290|uniprotkb:Q4VAI5|uniprotkb:Q4VAI6	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	psi-mi:cadh5_human(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)|uniprotkb:7B4 antigen(gene name synonym)	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bhattacharya et al. (2008)	pubmed:18662404|imex:IM-20499	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-2903141|imex:IM-20499-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001786.2|ensembl:ENSG00000179776(gene)|ensembl:ENST00000341529(transcript)|ensembl:ENST00000649567(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P33151|reactome:R-HSA-418990|reactome:R-HSA-5218920|dip:DIP-41172N	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	-	-	-	figure legend:fig 7|agonist:VEGF for Cadherin-5 and ZO-1|antagonist:dopamine for Cadherin-5 and ZO-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2010/08/06	2014/10/16	rogid:HzQQYMIWIEnMktuJKjc45wFfEDk9606	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	intact-crc:87A2505FE2903E6A|rigid:2q0E6ziXMR6wpT6j8rZ022aqn4Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33151	uniprotkb:P35968	intact:EBI-2903122|ensembl:ENSP00000344115|ensembl:ENSP00000497290|uniprotkb:Q4VAI5|uniprotkb:Q4VAI6	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	psi-mi:cadh5_human(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)|uniprotkb:7B4 antigen(gene name synonym)	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bhattacharya et al. (2008)	pubmed:18662404|imex:IM-20499	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-2903141|imex:IM-20499-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001786.2|ensembl:ENSG00000179776(gene)|ensembl:ENST00000341529(transcript)|ensembl:ENST00000649567(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P33151|reactome:R-HSA-418990|reactome:R-HSA-5218920|dip:DIP-41172N	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	-	-	-	figure legend:fig 7|agonist:VEGF for Cadherin-5 and ZO-1|antagonist:dopamine for Cadherin-5 and ZO-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2010/08/06	2014/10/16	rogid:HzQQYMIWIEnMktuJKjc45wFfEDk9606	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	intact-crc:87A2505FE2903E6A|rigid:2q0E6ziXMR6wpT6j8rZ022aqn4Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33151	uniprotkb:Q07157	intact:EBI-2903122|ensembl:ENSP00000344115|ensembl:ENSP00000497290|uniprotkb:Q4VAI5|uniprotkb:Q4VAI6	intact:EBI-79553|uniprotkb:B4E3K1|ensembl:ENSP00000281537|ensembl:ENSP00000484535|uniprotkb:Q2NKP3|uniprotkb:Q4ZGJ6	psi-mi:cadh5_human(display_long)|uniprotkb:CDH5(gene name)|psi-mi:CDH5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)|uniprotkb:7B4 antigen(gene name synonym)	psi-mi:zo1_human(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bhattacharya et al. (2008)	pubmed:18662404|imex:IM-20499	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1263"(Molecular Connections)	intact:EBI-2903141|imex:IM-20499-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001786.2|ensembl:ENSG00000179776(gene)|ensembl:ENST00000341529(transcript)|ensembl:ENST00000649567(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P33151|reactome:R-HSA-418990|reactome:R-HSA-5218920|dip:DIP-41172N	ensembl:ENSG00000104067(gene)|ensembl:ENSG00000277401(gene)|ensembl:ENST00000346128(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENST00000621049(transcript)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR035597|interpro:IPR036034|mint:Q07157|rcsb pdb:2H2B|rcsb pdb:2H2C|rcsb pdb:2H3M|rcsb pdb:2JWE|rcsb pdb:2KXR|rcsb pdb:2KXS|rcsb pdb:2RCZ|rcsb pdb:3CYY|rcsb pdb:3LH5|rcsb pdb:3SHU|rcsb pdb:3SHW|rcsb pdb:3TSV|rcsb pdb:3TSW|rcsb pdb:3TSZ|rcsb pdb:4OEO|rcsb pdb:4OEP|rcsb pdb:4Q2Q|rcsb pdb:4YYX|reactome:R-HSA-191650|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8935964|refseq:NP_003248.3|refseq:NP_783297.2	-	-	-	figure legend:fig 7|agonist:VEGF for Cadherin-5 and ZO-1|antagonist:dopamine for Cadherin-5 and ZO-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2010/08/06	2014/10/16	rogid:HzQQYMIWIEnMktuJKjc45wFfEDk9606	rogid:/Yi7U3TcH6kPu4A/bQ5Nj0QeU2w9606	intact-crc:87A2505FE2903E6A|rigid:2q0E6ziXMR6wpT6j8rZ022aqn4Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)