#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O60504 uniprotkb:Q9QWI6-2 intact:EBI-741237|ensembl:ENSP00000240123|uniprotkb:Q5BJE4|uniprotkb:Q6NX54|uniprotkb:Q9UQE4|intact:EBI-1222937|uniprotkb:Q96FY4 intact:EBI-775607 psi-mi:vinex_human(display_long)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short) psi-mi:q9qwi6-2(display_long)|uniprotkb:1b(isoform synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym) psi-mi:"MI:0018"(two hybrid) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658536|imex:IM-20478-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120896(gene)|ensembl:ENST00000240123(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0017166"(vinculin binding)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR028510|interpro:IPR035607|interpro:IPR035608|interpro:IPR035609|interpro:IPR036028|mint:O60504|rcsb pdb:2CT3|rcsb pdb:2DLM|rcsb pdb:2NWM|rcsb pdb:2YUP|reactome:R-HSA-445355|refseq:NP_001018003.1|refseq:NP_005766.3|refseq:XP_005273428.1|refseq:XP_016868433.1|refseq:XP_016868434.1|refseq:XP_016868435.1 intact:EBI-775592(snip_mouse) - - - figure legend:Fig. 7A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/05/13 2014/10/16 rogid:Mq3VXduU/1gqfUwliO9sBBOb/Vc9606 rogid:J7763Yk/elTmdSIph2IsmYf4WRw10090 intact-crc:8D3AF1EE9BE63C0F|rigid:eBzWj4XisyoHv8opc6P3Purq8bc false - sufficient binding region:1000-1216 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:B4DVR4 uniprotkb:Q9QWI6-2 intact:EBI-3636700 intact:EBI-775607 psi-mi:b4dvr4_human(display_long) psi-mi:q9qwi6-2(display_long)|uniprotkb:1b(isoform synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658645|imex:IM-20478-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036028|interpro:IPR001452(Src homology-3)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|interpro:IPR028510|interpro:IPR035607|interpro:IPR035608|interpro:IPR035609 intact:EBI-775592(snip_mouse) - - - figure legend:Fig. 7B|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:kPPq/kR9a8gXLZaiqZmydzXhNPo9606 rogid:J7763Yk/elTmdSIph2IsmYf4WRw10090 intact-crc:6162CBD629C04E63|rigid:ZAOKGOqnkbwYguvHkNzhYYQzQNc false flag tag:?-?|sufficient binding region:?-?(IPR001452) green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QWI6-2 uniprotkb:O60504-2 intact:EBI-775607 intact:EBI-1222956|ensembl:ENSP00000429764|intact:EBI-8080249|intact:EBI-8565573|intact:EBI-8565600|intact:EBI-7503501|intact:EBI-8080170|intact:EBI-8565332|intact:EBI-8565394|intact:EBI-7503561|intact:EBI-8080198|intact:EBI-8080221|intact:EBI-8565438|intact:EBI-8080138|intact:EBI-8597571|intact:EBI-8565301|intact:MINT-262507|intact:EBI-8597400|intact:EBI-8080321 psi-mi:q9qwi6-2(display_long)|uniprotkb:1b(isoform synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym) psi-mi:o60504-2(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658660|imex:IM-20478-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-775592(snip_mouse) ensembl:ENSG00000120896(gene)|ensembl:ENST00000523965(transcript)|intact:EBI-741237(vinex_human)|uniprotkb:O60504-2(isoform-parent) - - isoform-comment:Contains a phosphoserine at position 6. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. figure legend:Fig. 7C|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:J7763Yk/elTmdSIph2IsmYf4WRw10090 rogid:J/3fJkmrjmQg5ul/KWW06IGy4iM9606 intact-crc:82495746D616259C|rigid:IWpWw4836LyLXqdpJdkTuTqrqDM false sufficient binding region:1000-1048|green fluorescent protein tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O60504-2 uniprotkb:Q9QWI6-2 intact:EBI-1222956|ensembl:ENSP00000429764|intact:EBI-8080249|intact:EBI-8565573|intact:EBI-8565600|intact:EBI-7503501|intact:EBI-8080170|intact:EBI-8565332|intact:EBI-8565394|intact:EBI-7503561|intact:EBI-8080198|intact:EBI-8080221|intact:EBI-8565438|intact:EBI-8080138|intact:EBI-8597571|intact:EBI-8565301|intact:MINT-262507|intact:EBI-8597400|intact:EBI-8080321 intact:EBI-775607 psi-mi:o60504-2(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:q9qwi6-2(display_long)|uniprotkb:1b(isoform synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658714|imex:IM-20478-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120896(gene)|ensembl:ENST00000523965(transcript)|intact:EBI-741237(vinex_human)|uniprotkb:O60504-2(isoform-parent) intact:EBI-775592(snip_mouse) - isoform-comment:Contains a phosphoserine at position 6. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. - figure legend:Fig. 8B|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:J/3fJkmrjmQg5ul/KWW06IGy4iM9606 rogid:J7763Yk/elTmdSIph2IsmYf4WRw10090 intact-crc:0B75AD6D7E41EA03|rigid:cHRzHDEF5Bc2obO4pJ90Q4J7px0 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O60504-2 uniprotkb:O00401 intact:EBI-1222956|ensembl:ENSP00000429764|intact:EBI-8080249|intact:EBI-8565573|intact:EBI-8565600|intact:EBI-7503501|intact:EBI-8080170|intact:EBI-8565332|intact:EBI-8565394|intact:EBI-7503561|intact:EBI-8080198|intact:EBI-8080221|intact:EBI-8565438|intact:EBI-8080138|intact:EBI-8597571|intact:EBI-8565301|intact:MINT-262507|intact:EBI-8597400|intact:EBI-8080321 intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9 psi-mi:o60504-2(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658714|imex:IM-20478-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120896(gene)|ensembl:ENST00000523965(transcript)|intact:EBI-741237(vinex_human)|uniprotkb:O60504-2(isoform-parent) go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N - isoform-comment:Contains a phosphoserine at position 6. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. - figure legend:Fig. 8B|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:J/3fJkmrjmQg5ul/KWW06IGy4iM9606 rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606 intact-crc:0B75AD6D7E41EA03|rigid:cHRzHDEF5Bc2obO4pJ90Q4J7px0 false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QWI6-2 uniprotkb:O60504-2 intact:EBI-775607 intact:EBI-1222956|ensembl:ENSP00000429764|intact:EBI-8080249|intact:EBI-8565573|intact:EBI-8565600|intact:EBI-7503501|intact:EBI-8080170|intact:EBI-8565332|intact:EBI-8565394|intact:EBI-7503561|intact:EBI-8080198|intact:EBI-8080221|intact:EBI-8565438|intact:EBI-8080138|intact:EBI-8597571|intact:EBI-8565301|intact:MINT-262507|intact:EBI-8597400|intact:EBI-8080321 psi-mi:q9qwi6-2(display_long)|uniprotkb:1b(isoform synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym) psi-mi:o60504-2(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658726|imex:IM-20478-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-775592(snip_mouse) ensembl:ENSG00000120896(gene)|ensembl:ENST00000523965(transcript)|intact:EBI-741237(vinex_human)|uniprotkb:O60504-2(isoform-parent) - - isoform-comment:Contains a phosphoserine at position 6. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. figure legend:Figs. 8B, 9D|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:J7763Yk/elTmdSIph2IsmYf4WRw10090 rogid:J/3fJkmrjmQg5ul/KWW06IGy4iM9606 intact-crc:E79DBB1916C6B2FC|rigid:IWpWw4836LyLXqdpJdkTuTqrqDM false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O60504-2 uniprotkb:O00401 intact:EBI-1222956|ensembl:ENSP00000429764|intact:EBI-8080249|intact:EBI-8565573|intact:EBI-8565600|intact:EBI-7503501|intact:EBI-8080170|intact:EBI-8565332|intact:EBI-8565394|intact:EBI-7503561|intact:EBI-8080198|intact:EBI-8080221|intact:EBI-8565438|intact:EBI-8080138|intact:EBI-8597571|intact:EBI-8565301|intact:MINT-262507|intact:EBI-8597400|intact:EBI-8080321 intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9 psi-mi:o60504-2(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658736|imex:IM-20478-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120896(gene)|ensembl:ENST00000523965(transcript)|intact:EBI-741237(vinex_human)|uniprotkb:O60504-2(isoform-parent) go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N - isoform-comment:Contains a phosphoserine at position 6. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. - figure legend:Fig. 8B|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:J/3fJkmrjmQg5ul/KWW06IGy4iM9606 rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606 intact-crc:27A17027DE42A7EE|rigid:EZ5Vlyg1Cgb40QZ9yxpHCxhX43k false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P07825 uniprotkb:Q9QWI6-2 intact:EBI-976085|uniprotkb:Q499R3 intact:EBI-775607 psi-mi:syph_rat(display_long)|uniprotkb:Major synaptic vesicle protein p38(gene name synonym)|uniprotkb:Syp(gene name)|psi-mi:Syp(display_short) psi-mi:q9qwi6-2(display_long)|uniprotkb:1b(isoform synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658757|imex:IM-20478-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0060076"(excitatory synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0042734"(presynaptic membrane)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0000149"(SNARE binding)|go:"GO:0006897"(endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|rgd:3802|refseq:NP_036796.1|interpro:IPR008253(Marvel)|interpro:IPR001285(Synaptophysin/synaptoporin)|interpro:IPR028714|mint:P07825 intact:EBI-775592(snip_mouse) - - - figure legend:Fig. 9B|comment:The synaptophysin-p140Cap interaction was lost when synaptophysin delta-N or delta-C mutant was used instead of the wild type.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:nG9lA5IrA7dLVQ2QlJ7VhtruLLg10116 rogid:J7763Yk/elTmdSIph2IsmYf4WRw10090 intact-crc:6FA84F2053635955|rigid:gRFdYpJekIlBveQLYtpxpz54jjo false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P07825 uniprotkb:Q9QWI6-2 intact:EBI-976085|uniprotkb:Q499R3 intact:EBI-775607 psi-mi:syph_rat(display_long)|uniprotkb:Major synaptic vesicle protein p38(gene name synonym)|uniprotkb:Syp(gene name)|psi-mi:Syp(display_short) psi-mi:q9qwi6-2(display_long)|uniprotkb:1b(isoform synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658768|imex:IM-20478-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0060076"(excitatory synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0042734"(presynaptic membrane)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0000149"(SNARE binding)|go:"GO:0006897"(endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|rgd:3802|refseq:NP_036796.1|interpro:IPR008253(Marvel)|interpro:IPR001285(Synaptophysin/synaptoporin)|interpro:IPR028714|mint:P07825 intact:EBI-775592(snip_mouse) - - - figure legend:Fig. 9C|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:nG9lA5IrA7dLVQ2QlJ7VhtruLLg10116 rogid:J7763Yk/elTmdSIph2IsmYf4WRw10090 intact-crc:A744A2015DAA014F|rigid:gRFdYpJekIlBveQLYtpxpz54jjo false flag tag:?-? green fluorescent protein tag:?-?|necessary binding region:677-866 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O60504-2 uniprotkb:P07825 intact:EBI-1222956|ensembl:ENSP00000429764|intact:EBI-8080249|intact:EBI-8565573|intact:EBI-8565600|intact:EBI-7503501|intact:EBI-8080170|intact:EBI-8565332|intact:EBI-8565394|intact:EBI-7503561|intact:EBI-8080198|intact:EBI-8080221|intact:EBI-8565438|intact:EBI-8080138|intact:EBI-8597571|intact:EBI-8565301|intact:MINT-262507|intact:EBI-8597400|intact:EBI-8080321 intact:EBI-976085|uniprotkb:Q499R3 psi-mi:o60504-2(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:syph_rat(display_long)|uniprotkb:Major synaptic vesicle protein p38(gene name synonym)|uniprotkb:Syp(gene name)|psi-mi:Syp(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658780|imex:IM-20478-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120896(gene)|ensembl:ENST00000523965(transcript)|intact:EBI-741237(vinex_human)|uniprotkb:O60504-2(isoform-parent) go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0060076"(excitatory synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0042734"(presynaptic membrane)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0000149"(SNARE binding)|go:"GO:0006897"(endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|rgd:3802|refseq:NP_036796.1|interpro:IPR008253(Marvel)|interpro:IPR001285(Synaptophysin/synaptoporin)|interpro:IPR028714|mint:P07825 - isoform-comment:Contains a phosphoserine at position 6. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. - figure legend:Fig. 9D|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:J/3fJkmrjmQg5ul/KWW06IGy4iM9606 rogid:nG9lA5IrA7dLVQ2QlJ7VhtruLLg10116 intact-crc:C3535CA96F06FCBE|rigid:68FeppIlz5MyW4dwxqb/j22Zh24 false flag tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O60504-2 uniprotkb:Q9QWI6-2 intact:EBI-1222956|ensembl:ENSP00000429764|intact:EBI-8080249|intact:EBI-8565573|intact:EBI-8565600|intact:EBI-7503501|intact:EBI-8080170|intact:EBI-8565332|intact:EBI-8565394|intact:EBI-7503561|intact:EBI-8080198|intact:EBI-8080221|intact:EBI-8565438|intact:EBI-8080138|intact:EBI-8597571|intact:EBI-8565301|intact:MINT-262507|intact:EBI-8597400|intact:EBI-8080321 intact:EBI-775607 psi-mi:o60504-2(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:q9qwi6-2(display_long)|uniprotkb:1b(isoform synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658780|imex:IM-20478-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120896(gene)|ensembl:ENST00000523965(transcript)|intact:EBI-741237(vinex_human)|uniprotkb:O60504-2(isoform-parent) intact:EBI-775592(snip_mouse) - isoform-comment:Contains a phosphoserine at position 6. Initiator Met-1 is removed. Contains a N-acetylalanine at position 2. - figure legend:Fig. 9D|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:J/3fJkmrjmQg5ul/KWW06IGy4iM9606 rogid:J7763Yk/elTmdSIph2IsmYf4WRw10090 intact-crc:C3535CA96F06FCBE|rigid:68FeppIlz5MyW4dwxqb/j22Zh24 false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QXY2 uniprotkb:Q8CJ75 intact:EBI-1394088|uniprotkb:Q9QXY3|ensembl:ENSRNOP00000016070 intact:EBI-2658680 psi-mi:srcn1_rat(display_long)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Snip(gene name synonym)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym) psi-mi:q8cj75_rat(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658690|imex:IM-20478-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:708439|refseq:NP_062251.1|ensembl:ENSRNOG00000011475(gene)|ensembl:ENSRNOT00000016070(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse)|interpro:IPR022782|interpro:IPR026727|mint:Q9QXY2 interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|interpro:IPR028510|interpro:IPR035609|interpro:IPR036028|mint:Q8CJ75 - - - figure legend:Fig. 7D|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain-cerebellum)|taxid:10116(Rattus norvegicus) - 2010/05/13 2014/10/16 rogid:vpuj/e+VqyDmaw6L6ah6jUJv5kI10116 rogid:Zjz94jsAFjd6KYMwHk7cqHtuZks10116 intact-crc:74EE94DF554C1459|rigid:THn8usElrDPdWvWMbD7uIMD3Tpk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QXY2 uniprotkb:P07825 intact:EBI-1394088|uniprotkb:Q9QXY3|ensembl:ENSRNOP00000016070 intact:EBI-976085|uniprotkb:Q499R3 psi-mi:srcn1_rat(display_long)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Snip(gene name synonym)|uniprotkb:p140Cap(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym) psi-mi:syph_rat(display_long)|uniprotkb:Major synaptic vesicle protein p38(gene name synonym)|uniprotkb:Syp(gene name)|psi-mi:Syp(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2658751|imex:IM-20478-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:708439|refseq:NP_062251.1|ensembl:ENSRNOG00000011475(gene)|ensembl:ENSRNOT00000016070(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0098793"(presynapse)|interpro:IPR022782|interpro:IPR026727|mint:Q9QXY2 go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0060076"(excitatory synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0042734"(presynaptic membrane)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0000149"(SNARE binding)|go:"GO:0006897"(endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|rgd:3802|refseq:NP_036796.1|interpro:IPR008253(Marvel)|interpro:IPR001285(Synaptophysin/synaptoporin)|interpro:IPR028714|mint:P07825 - - - figure legend:Fig. 9A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain-cerebellum)|taxid:10116(Rattus norvegicus) - 2010/05/13 2014/10/16 rogid:vpuj/e+VqyDmaw6L6ah6jUJv5kI10116 rogid:nG9lA5IrA7dLVQ2QlJ7VhtruLLg10116 intact-crc:376801C80EBB1447|rigid:BPW965gyljH3n6bTExm4PKag1EE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O60504-1 uniprotkb:Q9QWI6-2 intact:EBI-1222953|ensembl:ENSP00000240123|intact:EBI-8565375|intact:MINT-262503|intact:EBI-7905024|intact:EBI-7271420 intact:EBI-775607 psi-mi:o60504-1(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:q9qwi6-2(display_long)|uniprotkb:1b(isoform synonym)|uniprotkb:Srcin1(gene name)|psi-mi:Srcin1(display_short)|uniprotkb:Kiaa1684(gene name synonym)|uniprotkb:P140(gene name synonym)|uniprotkb:SNAP-25-interacting protein(gene name synonym)|uniprotkb:p130Cas-associated protein(gene name synonym)|uniprotkb:p140Cap(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Ito et al. (2008) pubmed:18662323|imex:IM-20478 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2658701|imex:IM-20478-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120896(gene)|ensembl:ENST00000240123(transcript)|intact:EBI-741237(vinex_human) intact:EBI-775592(snip_mouse) go:"GO:0048471"(perinuclear region of cytoplasm) - - figure legend:Fig. 8A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/05/13 2014/10/16 rogid:Mq3VXduU/1gqfUwliO9sBBOb/Vc9606 rogid:J7763Yk/elTmdSIph2IsmYf4WRw10090 intact-crc:A7B0C4E0167C6E70|rigid:eBzWj4XisyoHv8opc6P3Purq8bc false flag tag:?-? myc tag:?-? - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining)