#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9P0V3	uniprotkb:Q9ULV3	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-2652948|uniprotkb:Q9NYM8|uniprotkb:Q9UHK4|uniprotkb:Q9Y3F9|uniprotkb:Q9Y3G0|uniprotkb:Q5SYW5|uniprotkb:Q5SYW3|uniprotkb:Q8WU72|uniprotkb:Q9H868|uniprotkb:A8K9J8|ensembl:ENSP00000362029|ensembl:ENSP00000489425|uniprotkb:B4E131|uniprotkb:B7ZAS8	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:ciz1_human(display_long)|uniprotkb:CIZ1(gene name)|psi-mi:CIZ1(display_short)|uniprotkb:LSFR1(gene name synonym)|uniprotkb:NP94(gene name synonym)|uniprotkb:ZNF356(gene name synonym)|uniprotkb:CDKN1A-interacting zinc finger protein 1(gene name synonym)|uniprotkb:Nuclear protein NP94(gene name synonym)|uniprotkb:Zinc finger protein 356(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653878|imex:IM-13772-47	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	refseq:NP_001124487.1|refseq:NP_001124488.1|refseq:NP_001124489.1|refseq:NP_001124490.1|refseq:NP_036259.2|refseq:XP_005251950.4|refseq:XP_006717102.2|refseq:NP_001244904.1|refseq:NP_001244905.1|ensembl:ENSG00000148337(gene)|ensembl:ENST00000372938(transcript)|ensembl:ENST00000634901(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR026811|interpro:IPR036236|go:"GO:0005886"(plasma membrane)|refseq:XP_005251945.2|refseq:XP_005251948.2|refseq:XP_016870085.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:ZjDQwT+PexCvP7x2bIAZn9nYepc9606	intact-crc:452A7AEB0B4D34FB|rigid:VYA1gmeYZbqz6l5lh3Y9I9tX4yc	false	-	sufficient binding region:193-898(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25786	uniprotkb:Q9P0V3	intact:EBI-359352|uniprotkb:Q9BRV9|uniprotkb:A8K400|uniprotkb:Q53YE8|ensembl:ENSP00000379676	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:psa1_human(display_long)|uniprotkb:PSMA1(gene name)|psi-mi:PSMA1(display_short)|uniprotkb:PROS30(gene name synonym)|uniprotkb:PSC2(gene name synonym)|uniprotkb:Proteasome component C2(gene name synonym)|uniprotkb:Macropain subunit C2(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C2(gene name synonym)|uniprotkb:Proteasome nu chain(gene name synonym)|uniprotkb:30 kDa prosomal protein(gene name synonym)|uniprotkb:HC2(gene name synonym)|uniprotkb:NU(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653888|imex:IM-13772-1	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002777.1|refseq:NP_683877.1|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000129084(gene)|ensembl:ENST00000396394(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002376"(immune system process)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035144|mint:P25786|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|dip:DIP-29369N	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tAADzZ1G9E/0BBeS8vybNx97v7k9606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:C567C10174CCBFBB|rigid:E7k5/UojPF+l+dUnEC7XpYGZlYg	false	sufficient binding region:1-263(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P0V3	uniprotkb:Q8N5S3	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-2653898|uniprotkb:Q8N7V4|uniprotkb:A0AV81|uniprotkb:A0AV79|ensembl:ENSP00000381631	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:cb073_human(display_long)|uniprotkb:C2orf73(gene name)|psi-mi:C2orf73(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653905|imex:IM-13772-48	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	refseq:XP_011530812.1|refseq:XP_011530815.1|refseq:NP_001093866.1|refseq:XP_005264190.1|refseq:XP_005264191.1|ensembl:ENSG00000177994(gene)|ensembl:ENST00000398634(transcript)|interpro:IPR031365	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:OVQ/WeSczVdPEVSIFjsRs+rtP/c9606	intact-crc:E41EFF6B291D5432|rigid:j2ijq0hErT+dkU04Zsu+LX7ZNNo	false	-	sufficient binding region:1-166(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P0V3	uniprotkb:Q9NV56	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-399076|uniprotkb:A8C4L5|ensembl:ENSP00000359518	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:mrgbp_human(display_long)|uniprotkb:MRGBP(gene name)|psi-mi:MRGBP(display_short)|uniprotkb:C20orf20(gene name synonym)|uniprotkb:MRG-binding protein(gene name synonym)|uniprotkb:Up-regulated in colon cancer 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653915|imex:IM-13772-2	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	refseq:NP_060740.1|ensembl:ENSG00000101189(gene)|ensembl:ENST00000370487(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016573"(histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|interpro:IPR012423(CT20)|mint:Q9NV56|rcsb pdb:2N1D|reactome:R-HSA-3214847|dip:DIP-29018N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:4bfrpXA+a7207TVMYyOyu9MVmKQ9606	intact-crc:EC35F7A4E98FCA50|rigid:mhk3aOBoK4TU5nYK4slS3BgdbLI	false	-	sufficient binding region:75-204(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P0V3	uniprotkb:Q99549	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-2653928|uniprotkb:Q5JPE5|uniprotkb:Q9BTP1|uniprotkb:B7Z6F9|uniprotkb:Q5JTQ0|uniprotkb:Q96MK4|uniprotkb:Q86TK3|ensembl:ENSP00000355388	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:mpp8_human(display_long)|uniprotkb:MPP8(gene name synonym)|uniprotkb:Two hybrid-associated protein 3 with RanBPM(gene name synonym)|uniprotkb:MPHOSPH8(gene name)|psi-mi:MPHOSPH8(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653925|imex:IM-13772-49	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	refseq:NP_059990.2|dip:DIP-56224N|ensembl:ENSG00000196199(gene)|ensembl:ENST00000361479(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0035064"(methylated histone binding)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|interpro:IPR000953(Chromo domain)|interpro:IPR002110(Ankyrin)|interpro:IPR016197(Chromo domain-like)|interpro:IPR020683|interpro:IPR023779|interpro:IPR023780|interpro:IPR036770|rcsb pdb:3LWE|rcsb pdb:3QO2|rcsb pdb:3R93|rcsb pdb:3SVM|rcsb pdb:6V2S	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:9QQ9BhqAsSk3vld/WxlewgUX+l09606	intact-crc:DF654F04D7A3FDA2|rigid:s3MoLSS3OLgGcHChYQRMObPuk+c	false	-	sufficient binding region:255-860(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11021	uniprotkb:Q9P0V3	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653945|imex:IM-13772-3	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:AAA62D14B50845AA|rigid:ye9Lq+P6ZSq6DNW+oybHq46CyPM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P0V3	uniprotkb:Q5VSY0	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-743722|uniprotkb:Q9BYI2|uniprotkb:Q96LI0|uniprotkb:Q9BYI1|uniprotkb:Q9H225|ensembl:ENSP00000365550	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:gkap1_human(display_long)|uniprotkb:GKAP42(gene name synonym)|uniprotkb:cGMP-dependent protein kinase-anchoring protein of 42 kDa(gene name synonym)|uniprotkb:FKSG21(orf name)|uniprotkb:GKAP1(gene name)|psi-mi:GKAP1(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653952|imex:IM-13772-50	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	ensembl:ENSG00000165113(gene)|refseq:NP_001129425.1|refseq:NP_079487.2|refseq:XP_011517360.1|refseq:XP_005252298.1|ensembl:ENST00000376371(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|interpro:IPR026109|dip:DIP-47324N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:WPAqDDTftv300tbwXkusTo6tmUo9606	intact-crc:C9A8B2925A01108F|rigid:UBNn17opyxaOvVw147s3/n6U0g4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UMS0	uniprotkb:Q9P0V3	intact:EBI-725252|uniprotkb:Q53QE5|uniprotkb:Q6VNZ8|uniprotkb:Q7Z5B1|uniprotkb:Q7Z5B2|uniprotkb:Q9Y322|uniprotkb:B4DUL9|ensembl:ENSP00000387219	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:nfu1_human(display_long)|uniprotkb:HIRA-interacting protein 5(gene name synonym)|uniprotkb:NFU1(gene name)|psi-mi:NFU1(display_short)|uniprotkb:CGI-33(orf name)|uniprotkb:HIRIP5(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653959|imex:IM-13772-4	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002755.1|refseq:NP_056515.2|refseq:NP_001002756.1|ensembl:ENSG00000169599(gene)|ensembl:ENST00000410022(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001075(NIF system FeS cluster assembly, NifU, C-terminal)|interpro:IPR014824(NIF system FeS cluster assembly, NifU-like scaffold, N-terminal)|interpro:IPR034904|interpro:IPR036498|rcsb pdb:2LTM|rcsb pdb:2M5O|refseq:XP_016859297.1	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:ilyUYSw8tpfn8DDWGsj96O6f7jk9606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:F5A81E584A0AB152|rigid:FlFUChUyC+XOzZENeX3M2qjsd5A	false	sufficient binding region:1-196(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43396	uniprotkb:Q9P0V3	intact:EBI-1048857|ensembl:ENSP00000217515|ensembl:ENSP00000464918	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:txnl1_human(display_long)|uniprotkb:32 kDa thioredoxin-related protein(gene name synonym)|uniprotkb:TXNL1(gene name)|psi-mi:TXNL1(display_short)|uniprotkb:TRP32(gene name synonym)|uniprotkb:TXL(gene name synonym)|uniprotkb:TXNL(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653969|imex:IM-13772-51	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004777.1|ensembl:ENSG00000091164(gene)|ensembl:ENST00000217515(transcript)|ensembl:ENST00000590954(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015036"(disulfide oxidoreductase activity)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010400(Protein of unknown function DUF1000)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|interpro:IPR037047|mint:O43396|rcsb pdb:1GH2|rcsb pdb:1WWY|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:XP_016881582.1	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:v3qpLTWgZZ1f4Tz/ixVYlSPv7Ro9606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:1121E8E430F2A074|rigid:NeyEk1vxzcPux4M1tIcZCviAbfs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P0V3	uniprotkb:Q99614	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653976|imex:IM-13772-5	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606	intact-crc:8D26C4DBF2DC5B7C|rigid:kOFZoMs4sr4fBur7zZYmcz1WhMM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P0V3	uniprotkb:Q5TC79	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-2653986|uniprotkb:Q5TC80|uniprotkb:Q96M87|uniprotkb:Q9BQ88|ensembl:ENSP00000356674|ensembl:ENSP00000415293	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:zbt37_human(display_long)|uniprotkb:ZBTB37(gene name)|psi-mi:ZBTB37(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653983|imex:IM-13772-52	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	refseq:XP_011508364.1|refseq:NP_001116242.1|refseq:NP_115911.1|refseq:XP_016858045.1|refseq:XP_016858046.1|refseq:XP_016858047.1|ensembl:ENSG00000185278(gene)|ensembl:ENST00000427304(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|ensembl:ENST00000367701(transcript)|refseq:NP_001333044.1|refseq:XP_006711641.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:8+zBG0fIyYCOJnd4UcHeDKVkeJ89606	intact-crc:F99FAA2A8C52883E|rigid:oryvqBXzKVsw3YDprgXeFdssm04	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5JTW2	uniprotkb:Q9P0V3	intact:EBI-2562690|uniprotkb:Q9H9N3|uniprotkb:A1A4S8|uniprotkb:Q5JTW1|uniprotkb:Q5JTW0|uniprotkb:Q5BJE3|intact:EBI-10968071|uniprotkb:E9PHX5|ensembl:ENSP00000411284	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:cep78_human(display_long)|uniprotkb:C9orf81(gene name synonym)|uniprotkb:CEP78(gene name)|psi-mi:CEP78(display_short)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653997|imex:IM-13772-6	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092272.1|refseq:NP_115547.1|refseq:NP_001317620.1|refseq:NP_001317622.1|refseq:NP_001317623.1|ensembl:ENSG00000148019(gene)|ensembl:ENST00000424347(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044782"(cilium organization)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR026212|interpro:IPR032675|mint:Q5JTW2|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:qtqlOeCnHrdYtYUFPxx8aMZ15is9606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:6B8545EC0DF44A28|rigid:0Vqd5BzCEl1Gvt/0812rpKjWepA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HB21	uniprotkb:Q9P0V3	intact:EBI-2652984|uniprotkb:Q9BVK0|uniprotkb:D3DRE2|uniprotkb:B3KQ55|ensembl:ENSP00000357986|ensembl:ENSP00000376547|ensembl:ENSP00000394416	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:pkha1_human(display_long)|uniprotkb:PLEKHA1(gene name)|psi-mi:PLEKHA1(display_short)|uniprotkb:TAPP1(gene name synonym)|uniprotkb:Tandem PH domain-containing protein 1(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654004|imex:IM-13772-53	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001974.1|refseq:NP_001182537.1|refseq:NP_067635.2|refseq:NP_001317107.1|refseq:XP_016871969.1|refseq:XP_016871970.1|refseq:XP_016871971.1|refseq:XP_016871979.1|refseq:XP_016871980.1|ensembl:ENSG00000107679(gene)|ensembl:ENST00000368990(transcript)|ensembl:ENST00000392799(transcript)|ensembl:ENST00000433307(transcript)|go:"GO:0001553"(luteinization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-HSA-1660499|rcsb pdb:1EAZ|refseq:XP_005270073.1|refseq:XP_005270078.1|ensembl:ENST00000368988|ensembl:ENSP00000357984|ensembl:ENSP00000357986|ensembl:ENSP00000376547|ensembl:ENSP00000394416	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:a4aD7YitZrTeGt2rr8x7+nikTlg9606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:ABA611F5BF99D2AC|rigid:61t19oDfKRBzIDgxikphsn3xo6A	false	sufficient binding region:7-404(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P0V3	uniprotkb:Q8WW22	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654014|imex:IM-13772-7	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606	intact-crc:2E807DF067A0E461|rigid:q/1w7m4vgpmzmtxPBipFtmuJUeE	false	-	sufficient binding region:55-397(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17987	uniprotkb:Q9P0V3	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654024|imex:IM-13772-54	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:9D90C0DC3A35DF63|rigid:8ISgym676/TUU4cJNuKo2BO9txU	false	sufficient binding region:6-556(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49368	uniprotkb:Q9P0V3	intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654034|imex:IM-13772-8	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:E0FEF8F9E69D9ECD|rigid:1gSPFaYbYoS/zedfy6YHCRoAv6U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02790	uniprotkb:Q9P0V3	intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654041|imex:IM-13772-55	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:64D4514B4356E439|rigid:ciNHe+0EFgf95dZO6VPjTGtI1p8	false	sufficient binding region:34-459(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14556	uniprotkb:Q9P0V3	intact:EBI-1057431|uniprotkb:O60823|uniprotkb:Q6JTT9|uniprotkb:Q9HCU6|uniprotkb:B2RC82|ensembl:ENSP00000222286	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:g3pt_human(display_long)|uniprotkb:GAPDHS(gene name)|psi-mi:GAPDHS(display_short)|uniprotkb:GAPD2(gene name synonym)|uniprotkb:GAPDH2(gene name synonym)|uniprotkb:GAPDS(gene name synonym)|uniprotkb:HSD35(orf name)|uniprotkb:HSD-35(orf name)|uniprotkb:Spermatogenic glyceraldehyde-3-phosphate dehydrogenase(gene name synonym)|uniprotkb:Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654061|imex:IM-13772-56	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055179.1|ensembl:ENSG00000105679(gene)|ensembl:ENST00000222286(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:O14556|rcsb pdb:3H9E|rcsb pdb:3PFW|rcsb pdb:5C7L|rcsb pdb:5C7O|reactome:R-HSA-390471|reactome:R-HSA-70171|reactome:R-HSA-70263	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:R2wl89TyWYfD57yzx6up8t7LfDE9606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:82EC74C9A243FA8F|rigid:+t8AYW2du2FGXsgwQ90F1PADJYQ	false	sufficient binding region:9-408(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P0V3	uniprotkb:Q9BWN1	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-748167|uniprotkb:Q8WTX2|intact:EBI-28975604|ensembl:ENSP00000300835|ensembl:ENSP00000441641	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:prr14_human(display_long)|uniprotkb:PRR14(gene name)|psi-mi:PRR14(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654051|imex:IM-13772-9	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	ensembl:ENSP00000300835|ensembl:ENSP00000441641|refseq:NP_076936.1|refseq:NP_001307393.1|ensembl:ENSG00000156858(gene)|ensembl:ENST00000300835(transcript)|ensembl:ENST00000542965(transcript)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0007517"(muscle organ development)|interpro:IPR026320|interpro:IPR028149	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:09dYdbqpgWweItEVD7Q6qHbEo7Q9606	intact-crc:02A7AACBA74DFD1D|rigid:FcFdMFpAAEx7ekBhD2yCiDV1iK8	false	-	sufficient binding region:249-585(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68DK7	uniprotkb:P46109	intact:EBI-2560816|ensembl:ENSP00000381543|uniprotkb:Q69Z03|uniprotkb:Q0VF46|intact:EBI-2654071	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:msl1_human(display_long)|uniprotkb:MSL1(gene name)|psi-mi:MSL1(display_short)|uniprotkb:MSL1L1(gene name synonym)|uniprotkb:Male-specific lethal 1-like 1(gene name synonym)|uniprotkb:Male-specific lethal-1 homolog 1(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654077|imex:IM-13772-10	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188895(gene)|ensembl:ENST00000398532(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0072487"(MSL complex)|interpro:IPR026711|interpro:IPR029332|interpro:IPR031840|mint:Q68DK7|rcsb pdb:4B7Y|rcsb pdb:4B86|rcsb pdb:4DNC|reactome:R-HSA-3214847|refseq:NP_001012241.1|refseq:XP_005257355.1|dip:DIP-56862N	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:sFenPEZNoGtpn1bDFoUzSJBPUBY9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:0ED24E89CC4619D5|rigid:3IzVB3HOmvZI5I94AICKYf2D4j0	false	sufficient binding region:1-351(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NZM3	uniprotkb:Q9BYJ9	intact:EBI-308689|uniprotkb:O95062|uniprotkb:Q15812|uniprotkb:Q9HAK4|uniprotkb:Q9NXE6|uniprotkb:Q9NYG0|uniprotkb:Q9NZM2|uniprotkb:Q9ULG4|ensembl:ENSP00000347244	intact:EBI-1051237|uniprotkb:Q8N3G5|uniprotkb:Q8TBT1|uniprotkb:Q96AN4|uniprotkb:Q96S57|uniprotkb:Q9BTI7|uniprotkb:Q9NX79|ensembl:ENSP00000359364	psi-mi:itsn2_human(display_long)|uniprotkb:ITSN2(gene name)|psi-mi:ITSN2(display_short)|uniprotkb:KIAA1256(gene name synonym)|uniprotkb:SH3D1B(gene name synonym)|uniprotkb:SWAP(gene name synonym)|uniprotkb:SH3 domain-containing protein 1B(gene name synonym)|uniprotkb:SH3P18(gene name synonym)|uniprotkb:SH3P18-like WASP-associated protein(gene name synonym)	psi-mi:ythd1_human(display_long)|uniprotkb:Dermatomyositis associated with cancer putative autoantigen 1(gene name synonym)|uniprotkb:YTHDF1(gene name)|psi-mi:YTHDF1(display_short)|uniprotkb:C20orf21(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654097|imex:IM-13772-11	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000347244|ensembl:ENST00000361999|ensembl:ENSP00000354561|ensembl:ENST00000406921|ensembl:ENSP00000384499|ensembl:ENSG00000198399(gene)|ensembl:ENST00000355123(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR027029|interpro:IPR035737|interpro:IPR035738|interpro:IPR035739|interpro:IPR035740|interpro:IPR035741|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|rcsb pdb:1J3T|rcsb pdb:1UDL|rcsb pdb:1UE9|rcsb pdb:1UFF|rcsb pdb:1UHF|rcsb pdb:3GF9|rcsb pdb:3JZY|rcsb pdb:4IIO|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_006268.2|refseq:NP_062541.3|refseq:NP_671494.2	refseq:NP_060268.2|ensembl:ENSG00000149658(gene)|ensembl:ENST00000370339(transcript)|go:"GO:0000932"(P-body)|go:"GO:0002376"(immune system process)|go:"GO:0002577"(regulation of antigen processing and presentation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070925"(organelle assembly)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:Q9BYJ9|rcsb pdb:4RCI|rcsb pdb:4RCJ	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:dxUqeWmW1uwOqgZ89UhT98/pt809606	rogid:uzNKPfwF7I+6hLk6l8iiDOhuBcQ9606	intact-crc:54E861B0170DC518|rigid:Z10jxUjAyltUxsEyxvvrrndKhO4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:Q9HB21	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-2652984|uniprotkb:Q9BVK0|uniprotkb:D3DRE2|uniprotkb:B3KQ55|ensembl:ENSP00000357986|ensembl:ENSP00000376547|ensembl:ENSP00000394416	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:pkha1_human(display_long)|uniprotkb:PLEKHA1(gene name)|psi-mi:PLEKHA1(display_short)|uniprotkb:TAPP1(gene name synonym)|uniprotkb:Tandem PH domain-containing protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654087|imex:IM-13772-57	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	refseq:NP_001001974.1|refseq:NP_001182537.1|refseq:NP_067635.2|refseq:NP_001317107.1|refseq:XP_016871969.1|refseq:XP_016871970.1|refseq:XP_016871971.1|refseq:XP_016871979.1|refseq:XP_016871980.1|ensembl:ENSG00000107679(gene)|ensembl:ENST00000368990(transcript)|ensembl:ENST00000392799(transcript)|ensembl:ENST00000433307(transcript)|go:"GO:0001553"(luteinization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-HSA-1660499|rcsb pdb:1EAZ|refseq:XP_005270073.1|refseq:XP_005270078.1|ensembl:ENST00000368988|ensembl:ENSP00000357984|ensembl:ENSP00000357986|ensembl:ENSP00000376547|ensembl:ENSP00000394416	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:a4aD7YitZrTeGt2rr8x7+nikTlg9606	intact-crc:BC87D1CD21790744|rigid:0cC38KeKrcVn6erT9q2kW2h41EQ	false	-	sufficient binding region:354-404(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NQY0	uniprotkb:Q6XZF7	intact:EBI-2653038|uniprotkb:Q9BVG2|uniprotkb:Q9NVY9|ensembl:ENSP00000276416	intact:EBI-2483419|ensembl:ENSP00000315659|uniprotkb:Q8IVY3|uniprotkb:Q9Y2L3	psi-mi:bin3_human(display_long)|uniprotkb:BIN3(gene name)|psi-mi:BIN3(display_short)	psi-mi:dnmbp_human(display_long)|uniprotkb:DNMBP(gene name)|psi-mi:DNMBP(display_short)|uniprotkb:KIAA1010(gene name synonym)|uniprotkb:Scaffold protein Tuba(gene name synonym)|uniprotkb:ARHGEF36(gene name synonym)|uniprotkb:TUBA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654114|imex:IM-13772-12	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011542888.1|refseq:NP_061158.1|ensembl:ENSG00000147439(gene)|ensembl:ENST00000276416(transcript)|go:"GO:0000917"(division septum assembly)|go:"GO:0005737"(cytoplasm)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008104"(protein localization)|go:"GO:0009826"(unidimensional cell growth)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051666"(actin cortical patch localization)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR037428	ensembl:ENSG00000107554(gene)|ensembl:ENST00000324109(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007568"(aging)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0098793"(presynapse)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035469|interpro:IPR035817|interpro:IPR035818|interpro:IPR035819|interpro:IPR035820|interpro:IPR035899|interpro:IPR036028|mint:Q6XZF7|rcsb pdb:1UG1|rcsb pdb:1UHC|rcsb pdb:4CC2|rcsb pdb:4CC3|rcsb pdb:4CC4|rcsb pdb:4CC7|rcsb pdb:4GLM|reactome:R-HSA-9013148|refseq:XP_011537861.1|refseq:NP_056036.1|refseq:NP_001305255.1|refseq:NP_001305256.1|dip:DIP-53822N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:BPnWqToFqQLXdT5NAUwZIZTraZY9606	rogid:Pnps+8tUGF35nxMUaPgDr5hzRzc9606	intact-crc:2BF3B29F912542AF|rigid:o5YWdtplw5MGy8R+1HoyRGk0xhU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6XZF7	uniprotkb:Q68EM7	intact:EBI-2483419|ensembl:ENSP00000315659|uniprotkb:Q8IVY3|uniprotkb:Q9Y2L3	intact:EBI-1642807|uniprotkb:A8K6M6|uniprotkb:Q6ZUS4|uniprotkb:Q7Z2F2|uniprotkb:Q8NDG2|uniprotkb:Q96KS2|uniprotkb:Q96KS3|uniprotkb:Q96SS8|uniprotkb:Q9BVF6|uniprotkb:Q9H8U5|uniprotkb:Q9NW54|intact:EBI-2398436|ensembl:ENSP00000289968|ensembl:ENSP00000500372	psi-mi:dnmbp_human(display_long)|uniprotkb:DNMBP(gene name)|psi-mi:DNMBP(display_short)|uniprotkb:KIAA1010(gene name synonym)|uniprotkb:Scaffold protein Tuba(gene name synonym)|uniprotkb:ARHGEF36(gene name synonym)|uniprotkb:TUBA(gene name synonym)	psi-mi:rhg17_human(display_long)|uniprotkb:ARHGAP17(gene name)|psi-mi:ARHGAP17(display_short)|uniprotkb:Rho-type GTPase-activating protein 17(gene name synonym)|uniprotkb:RhoGAP interacting with CIP4 homologs protein 1(gene name synonym)|uniprotkb:MSTP066(orf name)|uniprotkb:MSTP110(orf name)|uniprotkb:RICH1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654104|imex:IM-13772-58	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000107554(gene)|ensembl:ENST00000324109(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007568"(aging)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0098793"(presynapse)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035469|interpro:IPR035817|interpro:IPR035818|interpro:IPR035819|interpro:IPR035820|interpro:IPR035899|interpro:IPR036028|mint:Q6XZF7|rcsb pdb:1UG1|rcsb pdb:1UHC|rcsb pdb:4CC2|rcsb pdb:4CC3|rcsb pdb:4CC4|rcsb pdb:4CC7|rcsb pdb:4GLM|reactome:R-HSA-9013148|refseq:XP_011537861.1|refseq:NP_056036.1|refseq:NP_001305255.1|refseq:NP_001305256.1|dip:DIP-53822N	refseq:NP_001006635.1|refseq:NP_060524.4|ensembl:ENSG00000140750(gene)|ensembl:ENSG00000288353(gene)|ensembl:ENST00000289968(transcript)|ensembl:ENST00000673560(transcript)|go:"GO:0005096"(GTPase activator activity)|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013423|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035020"(regulation of Rac protein signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|go:"GO:0005654"(nucleoplasm)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:Pnps+8tUGF35nxMUaPgDr5hzRzc9606	rogid:ShqZATP0+ROgRhy0Afi5gqZ1JVY9606	intact-crc:646537599A6ED1B9|rigid:lc37PYhPmZkk535i94oslrcAP34	false	-	sufficient binding region:726-881(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62993	uniprotkb:Q9UKW4	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-297568|uniprotkb:O95230|uniprotkb:Q9Y5X8|uniprotkb:B1APV5|uniprotkb:B1AMM0|uniprotkb:B4E232|uniprotkb:B7ZLR1|uniprotkb:E9PQ97|uniprotkb:O60498|ensembl:ENSP00000359073	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:vav3_human(display_long)|uniprotkb:VAV3(gene name)|psi-mi:VAV3(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654131|imex:IM-13772-13	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	refseq:NP_001073343.1|refseq:NP_006104.4|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035734|interpro:IPR035881|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:Q9UKW4|rcsb pdb:2D86|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|ensembl:ENSG00000134215(gene)|ensembl:ENST00000370056(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001772"(immunological synapse)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_005270417.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:sCvtyb/upL3UweAEXaHjZEkKH6M9606	intact-crc:480837A1CFEECE03|rigid:AXlkDNRatugO4L96doNuQAKSa0E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60566	uniprotkb:Q6XZF7	intact:EBI-1001438|uniprotkb:B2R6U0|uniprotkb:B4DL09|uniprotkb:B4DLG3|uniprotkb:Q59HH6|uniprotkb:Q8WV50|intact:EBI-2551047|uniprotkb:O60501|uniprotkb:O60627|uniprotkb:O60758|uniprotkb:O75389|uniprotkb:Q96KM4|ensembl:ENSP00000287598	intact:EBI-2483419|ensembl:ENSP00000315659|uniprotkb:Q8IVY3|uniprotkb:Q9Y2L3	psi-mi:bub1b_human(display_long)|uniprotkb:MAD3/BUB1-related protein kinase(gene name synonym)|uniprotkb:Mitotic checkpoint kinase MAD3L(gene name synonym)|uniprotkb:SSK1(gene name synonym)|uniprotkb:BUB1B(gene name)|psi-mi:BUB1B(display_short)|uniprotkb:BUBR1(gene name synonym)|uniprotkb:MAD3L(gene name synonym)|uniprotkb:Protein SSK1(gene name synonym)	psi-mi:dnmbp_human(display_long)|uniprotkb:DNMBP(gene name)|psi-mi:DNMBP(display_short)|uniprotkb:KIAA1010(gene name synonym)|uniprotkb:Scaffold protein Tuba(gene name synonym)|uniprotkb:ARHGEF36(gene name synonym)|uniprotkb:TUBA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654121|imex:IM-13772-59	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001202.4|dip:DIP-24203N|ensembl:ENSG00000156970(gene)|ensembl:ENST00000287598(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000940"(outer kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|mint:O60566|rcsb pdb:2WVI|rcsb pdb:3SI5|rcsb pdb:4GGD|rcsb pdb:5JJA|rcsb pdb:5K6S|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:5SWF|rcsb pdb:6TLJ|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	ensembl:ENSG00000107554(gene)|ensembl:ENST00000324109(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007568"(aging)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0098793"(presynapse)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035469|interpro:IPR035817|interpro:IPR035818|interpro:IPR035819|interpro:IPR035820|interpro:IPR035899|interpro:IPR036028|mint:Q6XZF7|rcsb pdb:1UG1|rcsb pdb:1UHC|rcsb pdb:4CC2|rcsb pdb:4CC3|rcsb pdb:4CC4|rcsb pdb:4CC7|rcsb pdb:4GLM|reactome:R-HSA-9013148|refseq:XP_011537861.1|refseq:NP_056036.1|refseq:NP_001305255.1|refseq:NP_001305256.1|dip:DIP-53822N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:EgsQ2ZywEJ+r8hd95vcNEyikMBA9606	rogid:Pnps+8tUGF35nxMUaPgDr5hzRzc9606	intact-crc:751A0687D6B288E6|rigid:szxbkg7S7np2+z6XN6V+QCTX4pk	false	sufficient binding region:1-1050(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63010	uniprotkb:Q15811	intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654138|imex:IM-13772-60	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:575176B8AE0CBA58|rigid:azS7az3PxMLJ+ee+aDTNLqEb338	false	sufficient binding region:?-?(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15811	uniprotkb:O43150	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	intact:EBI-310968|uniprotkb:D6W4Y8|ensembl:ENSP00000281419	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:asap2_human(display_long)|uniprotkb:ASAP2(gene name)|psi-mi:ASAP2(display_short)|uniprotkb:KIAA0400(gene name synonym)|uniprotkb:Pyk2 C-terminus-associated protein(gene name synonym)|uniprotkb:Paxillin-associated protein with ARF GAP activity 3(gene name synonym)|uniprotkb:DDEF2(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654148|imex:IM-13772-14	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	ensembl:ENSP00000281419|ensembl:ENST00000315273|ensembl:ENSP00000316404|refseq:NP_001128663.1|refseq:NP_003878.1|ensembl:ENSG00000151693(gene)|ensembl:ENST00000281419(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR035677|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR038508|interpro:IPR043593|mint:O43150	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	rogid:Ye0xTNuPq3d3/1y/2mIFYH9ecNs9606	intact-crc:D64CB39AF5D7313E|rigid:m2rUtnpOMYJzDWlTlm+8z4zxJzI	false	-	sufficient binding region:500-1006(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:Q15811	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654158|imex:IM-13772-61	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:781FE60250BA4352|rigid:gQyWHcHysZESkNxEbovh1MB2Vjc	false	sufficient binding region:19-906(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZUJ8	uniprotkb:Q15811	intact:EBI-2654168|uniprotkb:Q8NAC8|uniprotkb:Q8N6J6|uniprotkb:Q5TB56|uniprotkb:Q5VXJ9|intact:EBI-2824934|ensembl:ENSP00000339826	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:bcap_human(display_long)|uniprotkb:BCAP(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:PIK3AP1(gene name)|psi-mi:PIK3AP1(display_short)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654176|imex:IM-13772-15	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689522.2|refseq:XP_005269555.1|refseq:XP_005269556.1|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|rcsb pdb:5FOR|rcsb pdb:6SWS|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-6811558|reactome:R-HSA-983695|ensembl:ENSG00000155629(gene)|ensembl:ENST00000339364(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:Vkm2cOoMpas9o9K/SirWHQy+lrw9606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:3BCB1A03D7A398F7|rigid:tT2gpVtFMrPY+DVOkLUJeiKatcI	false	sufficient binding region:463-805(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15427	uniprotkb:Q15811	intact:EBI-348469|ensembl:ENSP00000271628|intact:EBI-1047735|uniprotkb:Q5SZ63	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:sf3b4_human(display_long)|uniprotkb:SF3B4(gene name)|psi-mi:SF3B4(display_short)|uniprotkb:SAP49(gene name synonym)|uniprotkb:Spliceosome-associated protein 49(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 49 kDa subunit(gene name synonym)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654196|imex:IM-13772-16	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005841.1|ensembl:ENSG00000143368(gene)|ensembl:ENST00000271628(transcript)|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:6AHD|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|go:"GO:0000375"(RNA splicing, via transesterification reactions)|interpro:IPR034159|interpro:IPR035979|mint:Q15427|rcsb pdb:1X5T|rcsb pdb:5GVQ|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:Jgy6WmBFKkphpZLLte2GgsagUVI9606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:7113E8EEB1C2D596|rigid:cDou4ad1ncCUvB2A4gjQc4Vqh8c	false	sufficient binding region:324-424(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22674	uniprotkb:Q15811	intact:EBI-2556878|uniprotkb:Q9UMD5|uniprotkb:A8K1W5|uniprotkb:Q0P6J2|uniprotkb:Q9H6B0|ensembl:ENSP00000282572	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:ccno_human(display_long)|uniprotkb:CCNO(gene name)|psi-mi:CCNO(display_short)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654206|imex:IM-13772-62	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066970.3|ensembl:ENSG00000152669(gene)|ensembl:ENST00000282572(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0042493"|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028864|interpro:IPR036915|interpro:IPR039361|mint:P22674|go:"GO:0060271"(cilium assembly)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|dip:DIP-24234N	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:xo6sCdjzITrnnZad7Vd+ZB2eKcA9606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:3030C126C334778C|rigid:NRlI0R2SJHVwVU0RLMT0EgXAj4Y	false	sufficient binding region:82-350(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15811	uniprotkb:Q99471	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654186|imex:IM-13772-25	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606	intact-crc:E761C81CCD03F121|rigid:xwI/Og2oAyHtybHpTFRfRIVt/80	false	-	sufficient binding region:1-154(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99469	uniprotkb:P02545	intact:EBI-2652799|uniprotkb:B2R8S8|ensembl:ENSP00000273183	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:stac_human(display_long)|uniprotkb:STAC(gene name)|psi-mi:STAC(display_short)|uniprotkb:Src homology 3 and cysteine-rich domain-containing protein(gene name synonym)|uniprotkb:STAC1(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654226|imex:IM-13772-63	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003140.1|ensembl:ENSG00000144681(gene)|ensembl:ENST00000273183(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030315"(T-tubule)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001452(Src homology-3)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR035508|interpro:IPR036028|interpro:IPR039688|mint:Q99469|rcsb pdb:2DL4|rcsb pdb:6B25	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:8RqTwCIcB04azYqRuxegTSYkVf09606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:5EC95A2D2FFA5504|rigid:3npPauuzUNaarlnC/64Y25U/IrY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2W2	uniprotkb:Q15811	intact:EBI-714455|ensembl:ENSP00000261167|uniprotkb:Q96AY8	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	psi-mi:wbp11_human(display_long)|uniprotkb:SH3 domain-binding protein SNP70(gene name synonym)|uniprotkb:Npw38-binding protein(gene name synonym)|uniprotkb:WBP11(gene name)|psi-mi:WBP11(display_short)|uniprotkb:NPWBP(gene name synonym)|uniprotkb:SNP70(gene name synonym)|uniprotkb:SIPP1(gene name synonym)|uniprotkb:Splicing factor that interacts with PQBP-1 and PP1(gene name synonym)	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654216|imex:IM-13772-17	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:7ABG|reactome:R-HSA-72163|ensembl:ENSG00000084463(gene)|ensembl:ENST00000261167(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0050699"(WW domain binding)|interpro:IPR019007|mint:Q9Y2W2|rcsb pdb:7ABF|refseq:NP_057396.1	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:qE03bpSsQiJouJbn6ISt8DnD/pA9606	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	intact-crc:E6031FF598FD9440|rigid:L94MqUiw4/b7NzyOoMkHmVCu5ec	false	sufficient binding region:285-641(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:P22674	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-2556878|uniprotkb:Q9UMD5|uniprotkb:A8K1W5|uniprotkb:Q0P6J2|uniprotkb:Q9H6B0|ensembl:ENSP00000282572	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:ccno_human(display_long)|uniprotkb:CCNO(gene name)|psi-mi:CCNO(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654233|imex:IM-13772-18	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_066970.3|ensembl:ENSG00000152669(gene)|ensembl:ENST00000282572(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0042493"|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028864|interpro:IPR036915|interpro:IPR039361|mint:P22674|go:"GO:0060271"(cilium assembly)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|dip:DIP-24234N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:xo6sCdjzITrnnZad7Vd+ZB2eKcA9606	intact-crc:F0A6EFF7F61CA15A|rigid:TxW4fyPC6KMMSHFoLvkfIxprOs0	false	-	sufficient binding region:59-350(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43432	uniprotkb:P52735	intact:EBI-464766|uniprotkb:Q5SWC3|ensembl:ENSP00000264211|uniprotkb:Q15597|uniprotkb:Q8NEN1|uniprotkb:Q504Z1|uniprotkb:B9EGQ7	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:if4g3_human(display_long)|uniprotkb:EIF4G3(gene name)|psi-mi:EIF4G3(display_short)|uniprotkb:eIF-4-gamma II(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654261|imex:IM-13772-19	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000264211(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037585|mint:O43432|rcsb pdb:1HU3|reactome:R-HSA-1169408|ensembl:ENSG00000075151(gene)|refseq:NP_001185732.1|refseq:NP_003751.2|ensembl:ENSP00000264211|ensembl:ENST00000356916|ensembl:ENSP00000349386|ensembl:ENST00000374935|ensembl:ENSP00000364071|ensembl:ENST00000602326|ensembl:ENSP00000473510|ensembl:ENST00000682284|ensembl:ENSP00000507819|refseq:NP_001185731.1|refseq:NP_001185730.1|refseq:XP_016858189.1|refseq:XP_016858197.1|refseq:XP_016858201.1|dip:DIP-33245N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:dN5046U5kz1WfBJD0+NWYMMU6RY9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:392451575879675E|rigid:0hKsHMmMvRmX7DZ71ejCeCa1Beg	false	sufficient binding region:768-1585(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q58F21	uniprotkb:P52735	intact:EBI-2654243|uniprotkb:Q7Z4A6|uniprotkb:Q6P5T1|uniprotkb:O14789|uniprotkb:Q8IWI6|ensembl:ENSP00000354568|ensembl:ENSP00000384051|ensembl:ENSP00000387822|uniprotkb:A6NF68|uniprotkb:B7Z811|uniprotkb:B7Z890|uniprotkb:B7ZAX7|uniprotkb:D3DT32|uniprotkb:Q05DQ4	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:brdt_human(display_long)|uniprotkb:Cancer/testis antigen 9(gene name synonym)|uniprotkb:RING3-like protein(gene name synonym)|uniprotkb:BRDT(gene name)|psi-mi:BRDT(display_short)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654251|imex:IM-13772-64	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011540334.1|refseq:XP_011540335.1|refseq:XP_011540336.1|refseq:XP_011540337.1|refseq:XP_011540338.1|refseq:NP_001229735.2|refseq:NP_001229736.2|refseq:NP_001229737.2|refseq:NP_001229739.2|refseq:NP_001229734.2|refseq:NP_001717.3|refseq:NP_997072.2|ensembl:ENSG00000137948(gene)|ensembl:ENST00000362005(transcript)|ensembl:ENST00000399546(transcript)|ensembl:ENST00000402388(transcript)|go:"GO:0001207"(obsolete histone displacement)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008380"(RNA splicing)|go:"GO:0030154"(cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0051039"(positive regulation of transcription involved in meiotic cell cycle)|go:"GO:0070577"(lysine-acetylated histone binding)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|rcsb pdb:2RFJ|rcsb pdb:4FLP|rcsb pdb:4KCX|rcsb pdb:5VBQ|rcsb pdb:5VBR|rcsb pdb:7L73|rcsb pdb:7L99|rcsb pdb:7L9A|refseq:XP_006710916.1|refseq:XP_006710917.1|refseq:XP_006710918.1|refseq:XP_006710919.1|refseq:XP_006710920.1	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:erpgTXKmhS3kowFf8dHpN8s0mWw9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:237E88B48B3B8004|rigid:EgpZ3U3/iFqy+k0o5B5SNB1WC4k	false	sufficient binding region:89-947(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50502	uniprotkb:P52735	intact:EBI-357285|ensembl:ENSP00000216218|uniprotkb:O14999|uniprotkb:Q2TU77	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:f10a1_human(display_long)|uniprotkb:ST13(gene name)|psi-mi:ST13(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:SNC6(gene name synonym)|uniprotkb:AAG2(gene name synonym)|uniprotkb:Aging-associated protein 2(gene name synonym)|uniprotkb:FAM10A1(gene name synonym)|uniprotkb:Suppression of tumorigenicity 13 protein(gene name synonym)|uniprotkb:Putative tumor suppressor ST13(gene name synonym)|uniprotkb:Protein FAM10A1(gene name synonym)|uniprotkb:Progesterone receptor-associated p48 protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-33(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654281|imex:IM-13772-20	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100380(gene)|ensembl:ENST00000216218(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034649|interpro:IPR041243|mint:P50502|rcsb pdb:1UZS|reactome:R-HSA-3371453|refseq:NP_003923.2	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:yqG5t4Kuj7ZzfNwlJzGZYscKiM89606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:52FBAAE1013D8417|rigid:axuJlfsA8QVISNuY8u6+DnW+SLE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z6E9	uniprotkb:P52735	intact:EBI-2117026|uniprotkb:Q147T5|uniprotkb:Q15290|uniprotkb:Q6DKH4|uniprotkb:Q6P4C2|uniprotkb:Q6YNC9|uniprotkb:Q7Z6E8|uniprotkb:Q8N0V2|uniprotkb:Q96PH3|uniprotkb:Q9H3I8|uniprotkb:Q9H5M5|uniprotkb:Q9NPX4|ensembl:ENSP00000317872	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:rbbp6_human(display_long)|uniprotkb:Retinoblastoma-binding protein 6(gene name synonym)|uniprotkb:RBBP6(gene name)|psi-mi:RBBP6(display_short)|uniprotkb:P2PR(gene name synonym)|uniprotkb:PACT(gene name synonym)|uniprotkb:RBQ1(gene name synonym)|uniprotkb:p53-associated cellular protein of testis(gene name synonym)|uniprotkb:Proliferation potential-related protein(gene name synonym)|uniprotkb:Protein P2P-R(gene name synonym)|uniprotkb:Retinoblastoma-binding Q protein 1(gene name synonym)|uniprotkb:My038(orf name)|uniprotkb:RING-type E3 ubiquitin transferase RBBP6(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654271|imex:IM-13772-65	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008841.2|refseq:NP_061173.1|refseq:NP_116015.2|ensembl:ENSP00000317872|ensembl:ENST00000348022|ensembl:ENSP00000316291|ensembl:ENST00000381039|ensembl:ENSP00000370427|ensembl:ENST00000452655|ensembl:ENSP00000390537|dip:DIP-46897N|ensembl:ENSG00000122257(gene)|ensembl:ENST00000319715(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006397"(mRNA processing)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0048568"(embryonic organ development)|go:"GO:0061053"(somite development)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014891(DWNN domain)|interpro:IPR025829|interpro:IPR033489|interpro:IPR036875|rcsb pdb:2YSA|rcsb pdb:2YUR|rcsb pdb:3ZTG|rcsb pdb:6E5X|reactome:R-HSA-9013422|reactome:R-HSA-983168|rcsb pdb:2C7H	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:Kk3T/bDB7PKXO4ZC5Ej/Q1sf0Qw9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:88A42315AC70C403|rigid:wnhKcnw9rIi7TSMFlbK2OureJe8	false	sufficient binding region:22-1792(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96JH7	uniprotkb:P52735	intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654298|imex:IM-13772-21	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:56800E61384BDA0A|rigid:RwPTB7AvBTUVyB9l7YjoFP9utkg	false	sufficient binding region:674-1222(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:O75674	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-712991|intact:EBI-28969677|ensembl:ENSP00000460823|uniprotkb:Q53G06|uniprotkb:Q8N749|uniprotkb:B7Z9E2	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:tm1l1_human(display_long)|uniprotkb:Target of Myb-like protein 1(gene name synonym)|uniprotkb:Src-activating and signaling molecule protein(gene name synonym)|uniprotkb:TOM1L1(gene name)|psi-mi:TOM1L1(display_short)|uniprotkb:SRCASM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654288|imex:IM-13772-66	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	ensembl:ENSG00000141198(gene)|ensembl:ENST00000575882(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008942(ENTH/VHS)|interpro:IPR014645(Target of Myb protein 1)|interpro:IPR027428|mint:O75674|rcsb pdb:3RRU|interpro:IPR038425|refseq:NP_005477.2|ensembl:ENST00000348161|ensembl:ENSP00000343901|ensembl:ENST00000536554|ensembl:ENSP00000443099|ensembl:ENST00000570371|ensembl:ENSP00000458553|ensembl:ENST00000575333|ensembl:ENSP00000458918|ensembl:ENSP00000460823|refseq:NP_001308102.1|refseq:NP_001308103.1|refseq:NP_001308104.1|refseq:NP_001308105.1|refseq:XP_016879491.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:JQewIcPaPAlc2CknMG3p45OWbhI9606	intact-crc:B3B72D29AFD6CB4F|rigid:JdZB9pnIYy7PfttLU3PjbTNr2BA	false	-	sufficient binding region:1-476(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q8NFC6	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-2654318|uniprotkb:Q9NTD6|uniprotkb:Q96AL1|uniprotkb:Q9H6G0|uniprotkb:Q6P0M8|uniprotkb:Q9P2L9|ensembl:ENSP00000040738	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:bd1l1_human(display_long)|uniprotkb:BOD1L1(gene name)|psi-mi:BOD1L1(display_short)|uniprotkb:BOD1L(gene name synonym)|uniprotkb:FAM44A(gene name synonym)|uniprotkb:KIAA1327(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654330|imex:IM-13772-22	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_683692.2|ensembl:ENSG00000038219(gene)|ensembl:ENST00000040738(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031297"(replication fork processing)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0051721"(protein phosphatase 2A binding)|interpro:IPR043244|mint:Q8NFC6	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:/sFfw7CP8rOZG3hZNsT0npwIZIQ9606	intact-crc:9DAE4B3F38B059EA|rigid:deszpz3AO/2JiDOCjAxc4DfWJGI	false	-	sufficient binding region:106-3051(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q8ND90	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-302345|uniprotkb:O95144|uniprotkb:Q8NG07|ensembl:ENSP00000318914|uniprotkb:A8K4L5	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:pnma1_human(display_long)|uniprotkb:PNMA1(gene name)|psi-mi:PNMA1(display_short)|uniprotkb:MA1(gene name synonym)|uniprotkb:Neuron- and testis-specific protein 1(gene name synonym)|uniprotkb:37 kDa neuronal protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654308|imex:IM-13772-67	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_006020.4|ensembl:ENSG00000176903(gene)|ensembl:ENST00000316836(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR026523|interpro:IPR026528|mint:Q8ND90	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:/lx3CB7d/dv4xIgWQrCETPA0Qcw9606	intact-crc:B978C5AC27E41D5B|rigid:4mPm+ULs2cjds+KKWRg8GhXI5NQ	false	-	sufficient binding region:213-353(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:P49354	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-602336|uniprotkb:Q9UDC1|uniprotkb:A6NJW0|uniprotkb:Q53XJ9|ensembl:ENSP00000303423	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:fnta_human(display_long)|uniprotkb:CAAX farnesyltransferase subunit alpha(gene name synonym)|uniprotkb:Ras proteins prenyltransferase subunit alpha(gene name synonym)|uniprotkb:FTase-alpha(gene name synonym)|uniprotkb:Type I protein geranyl-geranyltransferase subunit alpha(gene name synonym)|uniprotkb:FNTA(gene name)|psi-mi:FNTA(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654350|imex:IM-13772-23	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_002018.1|ensembl:ENSG00000168522(gene)|ensembl:ENST00000302279(transcript)|go:"GO:0004660"(protein farnesyltransferase activity)|go:"GO:0004661"(protein geranylgeranyltransferase activity)|go:"GO:0004662"(CAAX-protein geranylgeranyltransferase activity)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005953"(CAAX-protein geranylgeranyltransferase complex)|go:"GO:0005965"(protein farnesyltransferase complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0018343"(protein farnesylation)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090044"(positive regulation of tubulin deacetylation)|go:"GO:0090045"(positive regulation of deacetylase activity)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|mint:P49354|rcsb pdb:1JCQ|rcsb pdb:1LD7|rcsb pdb:1LD8|rcsb pdb:1MZC|rcsb pdb:1S63|rcsb pdb:1SA4|rcsb pdb:1TN6|rcsb pdb:2F0Y|rcsb pdb:2H6F|rcsb pdb:2H6G|rcsb pdb:2H6H|rcsb pdb:2H6I|rcsb pdb:2IEJ|rcsb pdb:3E37|reactome:R-HSA-111465|reactome:R-HSA-2514859|reactome:R-HSA-9648002	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:2VOoFRlMYQR1v9oiOKl1sktjaa09606	intact-crc:FABCBFB4A317216C|rigid:ZWK9AP4NkPz2Y2IPBTOl8NFYZws	false	-	sufficient binding region:94-379(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q9BXP5	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-712721|uniprotkb:A4D2E5|uniprotkb:A6NK22|uniprotkb:Q32MI4|uniprotkb:Q9Y4S4|ensembl:ENSP00000480421|uniprotkb:O95808|uniprotkb:Q9BWP6|uniprotkb:Q9BXP4|uniprotkb:A4D2E6|uniprotkb:B4DJL4|uniprotkb:B4DZA6|uniprotkb:Q6NT74|uniprotkb:Q8TDQ5	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:srrt_human(display_long)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ASR2(gene name synonym)|uniprotkb:ARS2(gene name synonym)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654340|imex:IM-13772-68	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	ensembl:ENST00000611405(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007042(Arsenite-resistance protein 2)|interpro:IPR021933|interpro:IPR035979|interpro:IPR039727|mint:Q9BXP5|rcsb pdb:5OO6|rcsb pdb:6F7J|rcsb pdb:6F7P|rcsb pdb:6F7S|rcsb pdb:6F8D|reactome:R-HSA-6807505|reactome:R-HSA-72163|ensembl:ENSG00000087087(gene)|refseq:NP_001122324.1|refseq:NP_001122325.1|refseq:NP_001122326.1|refseq:NP_056992.4	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:upRnTwa7LTUzxnbGtfpJUejg2+w9606	intact-crc:FB8D4CF542312D72|rigid:pc+26Wncb6fJeLaDaGMIfjCA7Qc	false	-	sufficient binding region:197-876(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WWU5	uniprotkb:P52735	intact:EBI-2654360|uniprotkb:B7Z7B5|uniprotkb:B7Z7H4|uniprotkb:B7Z7S8|uniprotkb:E7EP29|uniprotkb:J3KNG1|uniprotkb:B3KQ27|uniprotkb:B2RCE9|uniprotkb:Q9NR39|uniprotkb:Q9NQZ9|uniprotkb:Q8NF85|ensembl:ENSP00000308708|ensembl:ENSP00000425995|uniprotkb:B7Z7G1	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:tcp11_human(display_long)|uniprotkb:TCP11(gene name)|psi-mi:TCP11(display_short)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654369|imex:IM-13772-69	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061149.1|refseq:NP_001248749.1|refseq:NP_001248750.1|refseq:NP_001087197.1|refseq:NP_001248746.1|refseq:NP_001248747.1|refseq:NP_001248748.1|ensembl:ENSG00000124678(gene)|ensembl:ENST00000311875(transcript)|ensembl:ENST00000512012(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0097225"(sperm midpiece)|go:"GO:1902490"(regulation of sperm capacitation)|interpro:IPR008862(T-complex 11)|go:"GO:0007165"(signal transduction)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:O+i/BPB3KDeHjkJjGkRVNNtL+rs9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:D30327EC04748B5C|rigid:zKt79ibOY60cNDursJdHcTWD4Wk	false	sufficient binding region:135-440(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q9H992	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-949983|ensembl:ENSP00000386830|ensembl:ENSP00000259050|uniprotkb:Q53GQ1|uniprotkb:Q9BTR9|uniprotkb:A8K9X1|uniprotkb:D3DPB0|uniprotkb:B7Z7P5	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:marh7_human(display_long)|uniprotkb:MARCHF7(gene name)|psi-mi:MARCHF7(display_short)|uniprotkb:AXOT(gene name synonym)|uniprotkb:Axotrophin(gene name synonym)|uniprotkb:MARCH7(gene name synonym)|uniprotkb:Membrane-associated RING finger protein 7(gene name synonym)|uniprotkb:Membrane-associated RING-CH protein VII(gene name synonym)|uniprotkb:RING finger protein 177(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MARCHF7(gene name synonym)|uniprotkb:RNF177(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654379|imex:IM-13772-24	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_001269734.1|refseq:NP_001269735.1|refseq:NP_001269736.1|ensembl:ENST00000259050(transcript)|ensembl:ENST00000409175(transcript)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016740"(transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0050821"(protein stabilization)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|ensembl:ENSG00000136536(gene)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|refseq:NP_073737.1|refseq:XP_005246830.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:HT4KtjhOVdeP4mam5eQhgX+ib5A9606	intact-crc:CF6EBDB61E1F1C4D|rigid:6/2ou1hew/J40Bp7+WMYy2ZK+EU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92598	uniprotkb:P52735	intact:EBI-356829|uniprotkb:O95739|uniprotkb:Q5TBM6|uniprotkb:Q5TBM8|uniprotkb:Q9UPC4|uniprotkb:Q5TBM7|intact:EBI-2859494|uniprotkb:B4DYH1|ensembl:ENSP00000318687	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:hs105_human(display_long)|uniprotkb:HSPH1(gene name)|psi-mi:HSPH1(display_short)|uniprotkb:HSP105(gene name synonym)|uniprotkb:HSP110(gene name synonym)|uniprotkb:KIAA0201(gene name synonym)|uniprotkb:Heat shock 110 kDa protein(gene name synonym)|uniprotkb:Antigen NY-CO-25(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654386|imex:IM-13772-70	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273432.1|refseq:NP_001273433.1|refseq:NP_001273434.1|refseq:NP_006635.2|ensembl:ENSG00000120694(gene)|ensembl:ENST00000320027(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042053|interpro:IPR043129|mint:Q92598|rcsb pdb:6GFA|reactome:R-HSA-3000484|reactome:R-HSA-3371453	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:FSdvp2KDHLmNpceRJ9HLY5IBfQA9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:49C7E113075A07AE|rigid:SnEzgfDpa0w/pXjeT4EQGdMpqPw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NB14	uniprotkb:P52735	intact:EBI-2512509|ensembl:ENSP00000303434|uniprotkb:Q9BY55|uniprotkb:Q96PZ6|uniprotkb:Q8NDF5|uniprotkb:B3KX93|uniprotkb:Q96DK6|uniprotkb:Q3ZCV1	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:ubp38_human(display_long)|uniprotkb:USP38(gene name)|psi-mi:USP38(display_short)|uniprotkb:KIAA1891(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 38(gene name synonym)|uniprotkb:Deubiquitinating enzyme 38(gene name synonym)|uniprotkb:HP43.8KD(gene name synonym)|uniprotkb:Ubiquitin thioesterase 38(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654410|imex:IM-13772-27	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170185(gene)|ensembl:ENST00000307017(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033840|go:"GO:0016579"(protein deubiquitination)|interpro:IPR038765|rcsb pdb:4RXX|refseq:NP_001277254.1|refseq:NP_001277255.1|refseq:NP_115946.2	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:huO1Ev3rX0NZ/kNU5vtcNUfqTtw9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:E221B289239B8D78|rigid:0C27UyCE03msKEfb37/qofxIkl4	false	sufficient binding region:469-1042(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7L1Q6	uniprotkb:P52735	intact:EBI-1046727|ensembl:ENSP00000386474|intact:EBI-1051097|uniprotkb:Q14281|uniprotkb:Q15394|uniprotkb:Q9BUY0|uniprotkb:B4DLZ8|uniprotkb:B4DWF7|intact:EBI-21351780	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:bzw1_human(display_long)|uniprotkb:BZW1(gene name)|psi-mi:BZW1(display_short)|uniprotkb:BZAP45(gene name synonym)|uniprotkb:KIAA0005(gene name synonym)|uniprotkb:Protein Orf(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654393|imex:IM-13772-26	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193996.1|refseq:NP_055485.2|ensembl:ENSG00000082153(gene)|ensembl:ENST00000409600(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043510|mint:Q7L1Q6|refseq:NP_001193997.1|refseq:NP_001193998.1|refseq:NP_001308617.1|refseq:NP_001308619.1|refseq:NP_001308620.1|refseq:NP_001308622.1|refseq:NP_001308623.1	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:4dzFp6AN4tymPA5rHNYlHCCmSaY9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:29E698E3DEBE1A75|rigid:8EEgdGOZccspZWJB+8MUU77zqLU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q8NC51	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-523558|uniprotkb:Q8WUH0|uniprotkb:Q96SE2|uniprotkb:Q9BTY3|uniprotkb:Q9BUM4|uniprotkb:Q9Y367|uniprotkb:Q9Y4S3|uniprotkb:Q5VU19|intact:EBI-1058614|ensembl:ENSP00000360034|uniprotkb:Q5VU20|uniprotkb:Q5VU22	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:pairb_human(display_long)|uniprotkb:PAI1 RNA-binding protein 1(gene name synonym)|uniprotkb:SERPINE1 mRNA-binding protein 1(gene name synonym)|uniprotkb:CGI-55(orf name)|uniprotkb:SERBP1(gene name)|psi-mi:SERBP1(display_short)|uniprotkb:PAIRBP1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654400|imex:IM-13772-71	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	ensembl:ENSG00000142864(gene)|ensembl:ENST00000370995(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030578"(PML body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR027205|interpro:IPR032381|interpro:IPR039764|mint:Q8NC51|rcsb pdb:4V6X|rcsb pdb:6Z6M|rcsb pdb:6Z6N|refseq:NP_001018077.1|refseq:NP_001018078.1|refseq:NP_001018079.1|refseq:NP_056455.3|dip:DIP-33819N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:lVkIPRkoXs3B4Qop1pA2zG/RKlo9606	intact-crc:84193BF68CD3B2E2|rigid:NxwnqaQ1gjxs7ryhZXSBP3BRy8g	false	-	sufficient binding region:1-408(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95155	uniprotkb:P52735	intact:EBI-1641720|uniprotkb:O75169|uniprotkb:O95338|uniprotkb:Q5SZ12|uniprotkb:Q5SZ16|uniprotkb:Q96QD4|uniprotkb:Q9BYI7|uniprotkb:A8K8S9|uniprotkb:G0ZJH6|ensembl:ENSP00000343001	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:ube4b_human(display_long)|uniprotkb:UBE4B(gene name)|psi-mi:UBE4B(display_short)|uniprotkb:HDNB1(gene name synonym)|uniprotkb:KIAA0684(gene name synonym)|uniprotkb:UFD2(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Homozygously deleted in neuroblastoma 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase E4 B(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654420|imex:IM-13772-72	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001099032.1|refseq:NP_006039.2|refseq:XP_005263479.1|dip:DIP-40309N|ensembl:ENSG00000130939(gene)|ensembl:ENST00000343090(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008626"(granzyme-mediated apoptotic signaling pathway)|go:"GO:0009411"(response to UV)|go:"GO:0019899"(enzyme binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051117"(ATPase binding)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019474|mint:O95155|rcsb pdb:2KRE|rcsb pdb:3L1X|rcsb pdb:3L1Z|rcsb pdb:5O75	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:CVE1n0Drv2d/OyLGjGIhRNJrtRQ9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:49C336238AB7472D|rigid:lxffVQ00nB4bKzqlTNv+Mqum71I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q14C86	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-1049788|intact:EBI-1384220|intact:EBI-2654427|uniprotkb:Q8ND92|uniprotkb:Q9P207|uniprotkb:Q9Y4N0|uniprotkb:A8MYK3|uniprotkb:Q14C76|uniprotkb:Q2Q1W1|uniprotkb:Q8WU86|uniprotkb:Q96CZ4|uniprotkb:Q9NXQ1|uniprotkb:B0QZ62|uniprotkb:B0QZ63|uniprotkb:B0QZ64|intact:EBI-2558352|ensembl:ENSP00000377664|ensembl:ENSP00000419063	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:gapd1_human(display_long)|uniprotkb:GAPVD1(gene name)|psi-mi:GAPVD1(display_short)|uniprotkb:GAPEX5(gene name synonym)|uniprotkb:KIAA1521(gene name synonym)|uniprotkb:RAP6(gene name synonym)|uniprotkb:Rab5-activating protein 6(gene name synonym)|uniprotkb:GAPex-5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654444|imex:IM-13772-28	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_001269608.1|refseq:NP_001269609.1|refseq:NP_001269610.1|refseq:NP_001317707.1|refseq:XP_016870095.1|refseq:XP_016870096.1|refseq:XP_016870097.1|refseq:NP_056450.2|refseq:XP_016870098.1|refseq:XP_005251961.1|ensembl:ENSG00000165219(gene)|ensembl:ENST00000394104(transcript)|ensembl:ENST00000495955(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051223"(regulation of protein transport)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR037191|interpro:IPR041545|mint:Q14C86|reactome:R-HSA-8856828|reactome:R-HSA-8876198|refseq:XP_006717107.1|refseq:XP_005251958.1|refseq:XP_016870090.1|refseq:XP_016870091.1|refseq:XP_016870092.1|refseq:XP_016870093.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:SX6gvb2Odit7L3I+Dtc5ub+qixE9606	intact-crc:E356F072FD8861A1|rigid:1FNuQCjupVDXYk7IgNje/ep7qS0	false	-	sufficient binding region:1-549(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z3K3	uniprotkb:P52735	intact:EBI-1389308|uniprotkb:O75049|uniprotkb:Q5SZS2|uniprotkb:Q5SZS3|uniprotkb:Q5SZS4|uniprotkb:Q8TDZ7|uniprotkb:Q9Y4X7|uniprotkb:Q3LIC4|uniprotkb:Q5SZS1|intact:EBI-2560449|intact:EBI-11742841|uniprotkb:B4DTP8|uniprotkb:B4DYL9|uniprotkb:B7ZBY5|uniprotkb:E9PM80|intact:EBI-14072025|intact:EBI-17205119|intact:EBI-22321456|intact:EBI-12748249|intact:EBI-16429759|ensembl:ENSP00000271715	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:pogz_human(display_long)|uniprotkb:POGZ(gene name)|psi-mi:POGZ(display_short)|uniprotkb:KIAA0461(gene name synonym)|uniprotkb:Nbla00003(orf name)|uniprotkb:SUHW5(gene name synonym)|uniprotkb:ZNF280E(gene name synonym)|uniprotkb:ZNF635(gene name synonym)|uniprotkb:Suppressor of hairy wing homolog 5(gene name synonym)|uniprotkb:Zinc finger protein 280E(gene name synonym)|uniprotkb:Zinc finger protein 635(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654454|imex:IM-13772-73	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001181866.1|refseq:NP_001181867.1|refseq:NP_055915.2|refseq:NP_665739.3|refseq:NP_997054.1|refseq:XP_016856234.1|refseq:XP_016856235.1|refseq:XP_016856237.1|refseq:XP_016856238.1|refseq:XP_005245056.1|refseq:XP_005245057.1|refseq:XP_005245058.1|refseq:XP_005245062.1|refseq:XP_005245063.1|dip:DIP-38044N|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000143442(gene)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|ensembl:ENST00000271715(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0051382"(kinetochore assembly)|interpro:IPR004875(CENP-B protein)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q7Z3K3|rcsb pdb:2E72|rcsb pdb:2N3A|rcsb pdb:6EMP	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:sCOIY8KsHRQtfcoSA9Tixl9yIsc9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:1E9EBC46640A0FC9|rigid:FmQW4xxitoV7udP2w+z8lVhx57I	false	sufficient binding region:427-1410(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NV56	uniprotkb:P52735	intact:EBI-399076|uniprotkb:A8C4L5|ensembl:ENSP00000359518	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:mrgbp_human(display_long)|uniprotkb:MRGBP(gene name)|psi-mi:MRGBP(display_short)|uniprotkb:C20orf20(gene name synonym)|uniprotkb:MRG-binding protein(gene name synonym)|uniprotkb:Up-regulated in colon cancer 4(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654464|imex:IM-13772-29	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060740.1|ensembl:ENSG00000101189(gene)|ensembl:ENST00000370487(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016573"(histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|interpro:IPR012423(CT20)|mint:Q9NV56|rcsb pdb:2N1D|reactome:R-HSA-3214847|dip:DIP-29018N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:4bfrpXA+a7207TVMYyOyu9MVmKQ9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:45C2E02DF9447B35|rigid:dVp8tINFdx2/WHo0Ed2TfUaZ9cM	false	sufficient binding region:39-204(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q12874	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-1051880|uniprotkb:Q15460|uniprotkb:Q5VT87|uniprotkb:D3DPT5|ensembl:ENSP00000362110	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:sf3a3_human(display_long)|uniprotkb:Spliceosome-associated protein 61(gene name synonym)|uniprotkb:SF3a60(gene name synonym)|uniprotkb:SF3A3(gene name)|psi-mi:SF3A3(display_short)|uniprotkb:SAP61(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654484|imex:IM-13772-30	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_006793.1|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR021966|interpro:IPR024598|interpro:IPR031774|interpro:IPR031776|mint:Q12874|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|go:"GO:0000389"(mRNA 3'-splice site recognition)|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|reactome:R-HSA-72163|rcsb pdb:6Y53|ensembl:ENSG00000183431(gene)|ensembl:ENST00000373019(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-882N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:fNjNguUOXqApr46rOAEpTs2geqY9606	intact-crc:5385FC0F2FBEA4F4|rigid:LqQrGBLwOD2QGftWiojm/5FPUtg	false	-	sufficient binding region:27-501(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15633	uniprotkb:P52735	intact:EBI-978581|uniprotkb:Q12878|ensembl:ENSP00000266987|uniprotkb:Q9BRY2|uniprotkb:Q8WY32|uniprotkb:Q8WY33	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:trbp2_human(display_long)|uniprotkb:Trans-activation-responsive RNA-binding protein(gene name synonym)|uniprotkb:TARBP2(gene name)|psi-mi:TARBP2(display_short)|uniprotkb:TRBP(gene name synonym)|uniprotkb:TAR RNA-binding protein 2(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654474|imex:IM-13772-74	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000139546(gene)|ensembl:ENST00000266987(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0016442"(RISC complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050689"(negative regulation of defense response to virus by host)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090065"(regulation of production of siRNA involved in RNA interference)|go:"GO:1903798"(regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR028605|interpro:IPR044469|interpro:IPR044470|interpro:IPR044471|mint:Q15633|rcsb pdb:2CPN|rcsb pdb:3ADL|rcsb pdb:3LLH|rcsb pdb:4WYQ|go:"GO:0016604"(nuclear body)|rcsb pdb:5N8L|rcsb pdb:5N8M|rcsb pdb:5ZAK|rcsb pdb:5ZAL|rcsb pdb:5ZAM|rcsb pdb:6ZBK|reactome:R-HSA-203927|reactome:R-HSA-426486|refseq:NP_004169.3|refseq:NP_599150.1|refseq:NP_599151.2|refseq:XP_005269171.1|refseq:XP_005269172.1|dip:DIP-29665N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:2pOFQwyM408mDl2bYsKEb1yhFrE9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:3D5451815EA397EE|rigid:agVXEg1rY2uqaK2J1HG0kl3+iMc	false	sufficient binding region:21-366(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13573	uniprotkb:P52735	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654494|imex:IM-13772-75	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:029BC809EAA40F9C|rigid:2XJerMoAK0KrE9YFCv8pd6BwkBo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q8TEX9	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-395967|uniprotkb:Q2NL96|uniprotkb:Q86TZ9|uniprotkb:Q8NCG8|uniprotkb:Q96SJ3|uniprotkb:Q9BTI4|uniprotkb:Q9H5L0|uniprotkb:B2RN95|ensembl:ENSP00000346453|ensembl:ENSP00000494795	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:ipo4_human(display_long)|uniprotkb:IPO4(gene name)|psi-mi:IPO4(display_short)|uniprotkb:IMP4B(gene name synonym)|uniprotkb:RANBP4(gene name synonym)|uniprotkb:Importin-4b(gene name synonym)|uniprotkb:Ran-binding protein 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654501|imex:IM-13772-31	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_078934.3|dip:DIP-32944N|ensembl:ENSG00000196497(gene)|ensembl:ENSG00000285248(gene)|ensembl:ENST00000354464(transcript)|ensembl:ENST00000644546(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|interpro:IPR040122|mint:Q8TEX9|rcsb pdb:5XAH|rcsb pdb:5XBK	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:PVIcGG3WTf0QmYbS0vvy049EjlQ9606	intact-crc:A36CB467C3200D6F|rigid:YFJhjUJoyc9Q9KedzNT8UoyG7qo	false	-	sufficient binding region:697-1081(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:P04066	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-2512153|ensembl:ENSP00000363603|uniprotkb:Q14335|uniprotkb:Q8NAC2|uniprotkb:Q3LID0|uniprotkb:Q14334|uniprotkb:B2RBG3	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:fuco_human(display_long)|uniprotkb:FUCA1(gene name)|psi-mi:FUCA1(display_short)|uniprotkb:Alpha-L-fucoside fucohydrolase 1(gene name synonym)|uniprotkb:Alpha-L-fucosidase I(gene name synonym)|uniprotkb:Nbla10230(orf name)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654511|imex:IM-13772-76	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	ensembl:ENSG00000179163(gene)|ensembl:ENST00000374479(transcript)|go:"GO:0004560"(alpha-L-fucosidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006004"(fucose metabolic process)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0019377"(glycolipid catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000933("Glycoside hydrolase, family 29 (alpha-L-fucosidase)")|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR016286(Alpha-L-fucosidase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR018526|interpro:IPR028755|interpro:IPR031919|mint:P04066|reactome:R-HSA-6798695|reactome:R-HSA-975578|refseq:NP_000138.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:hzGxBObvRAGMJxL+I9shJUo+nLg9606	intact-crc:0060A045D11D43FA|rigid:1tlSJOvbvYFEh1HP0YO1d3d7zAc	false	-	sufficient binding region:321-466(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y3E7	uniprotkb:P52735	intact:EBI-2118119|uniprotkb:B4DG34|uniprotkb:B8ZZM0|uniprotkb:Q3ZTS9|uniprotkb:Q53S71|uniprotkb:Q53SU5|uniprotkb:Q9NZ51|uniprotkb:A8K3W0|uniprotkb:B8ZZX5|intact:EBI-2563192|ensembl:ENSP00000263856	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:chmp3_human(display_long)|uniprotkb:CHMP3(gene name)|psi-mi:CHMP3(display_short)|uniprotkb:CGI149(gene name synonym)|uniprotkb:Chromatin-modifying protein 3(gene name synonym)|uniprotkb:NEDF(gene name synonym)|uniprotkb:Neuroendocrine differentiation factor(gene name synonym)|uniprotkb:VPS24(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 24(gene name synonym)|uniprotkb:CGI-149(orf name)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654521|imex:IM-13772-32	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005753.1|refseq:NP_001180446.1|refseq:NP_057163.1|refseq:NP_001185883.1|dip:DIP-48532N|ensembl:ENSG00000115561(gene)|ensembl:ENST00000263856(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051258"(protein polymerization)|go:"GO:0061763"(multivesicular body-lysosome fusion)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:1902187"|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR005024(Snf7)|mint:Q9Y3E7|rcsb pdb:2GD5|rcsb pdb:2XZE|rcsb pdb:3FRT|rcsb pdb:3FRV|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:mQEFHnkxyS1ZOfqKqGg9KtOjJFQ9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:F40D6FD5DDCEE611|rigid:HjRXVNrwmmydt1kDmOFzTpqDkTQ	false	sufficient binding region:42-222(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14513	uniprotkb:P52735	intact:EBI-1752508|uniprotkb:B8ZZL0|uniprotkb:Q29SS9|uniprotkb:Q29ST0|uniprotkb:Q2NL90|uniprotkb:Q6ZVE2|uniprotkb:Q8NAS3|ensembl:ENSP00000387128	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:nckp5_human(display_long)|uniprotkb:NCKAP5(gene name)|psi-mi:NCKAP5(display_short)|uniprotkb:ERIH(gene name synonym)|uniprotkb:Peripheral clock protein(gene name synonym)|uniprotkb:NAP5(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654531|imex:IM-13772-77	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997246.2|refseq:NP_997364.3|refseq:XP_016859469.1|ensembl:ENSG00000176771(gene)|ensembl:ENST00000409261(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0035371"(microtubule plus-end)|interpro:IPR026163|interpro:IPR032769	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:5wfrv6Xbl72amYUh/TelhsehaXw9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:8EBCCD87AB0D2D9C|rigid:FDSdhlUP+PpbBPsjwSEENKmmcDY	false	sufficient binding region:657-1900(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13503	uniprotkb:P52735	intact:EBI-394678|uniprotkb:Q6IB05|uniprotkb:Q92811|uniprotkb:B2R4I3|ensembl:ENSP00000282892	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:med21_human(display_long)|uniprotkb:SRB7(gene name synonym)|uniprotkb:MED21(gene name)|psi-mi:MED21(display_short)|uniprotkb:Mediator complex subunit 21(gene name synonym)|uniprotkb:RNA polymerase II holoenzyme component SRB7(gene name synonym)|uniprotkb:SURB7(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654551|imex:IM-13772-78	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004255.2|ensembl:ENSG00000152944(gene)|ensembl:ENST00000282892(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001824"(blastocyst development)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR021384|interpro:IPR037212|mint:Q13503|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340|dip:DIP-31471N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:qNrBcd6tolQzcRyFK/OdD3P1Q3g9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:029CB87C9A860FCC|rigid:Sh50XdbxAYOysmiUTPjJ+kglrik	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5SW79	uniprotkb:P52735	intact:EBI-1104799|uniprotkb:O75058|uniprotkb:Q5SW77|uniprotkb:Q5SW78|uniprotkb:Q7LGA9|uniprotkb:Q86W31|uniprotkb:Q9UQ08|uniprotkb:Q9UQ09|intact:EBI-2559293|intact:EBI-2554822|ensembl:ENSP00000355500|ensembl:ENSP00000483344	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:ce170_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)|uniprotkb:FAM68A(gene name synonym)|uniprotkb:KAB(gene name synonym)|uniprotkb:KIAA0470(gene name synonym)|uniprotkb:KARP-1-binding protein(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654541|imex:IM-13772-33	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035863.1|refseq:NP_001035864.1|refseq:NP_055627.2|ensembl:ENSG00000143702(gene)|ensembl:ENSG00000276725(gene)|ensembl:ENST00000366542(transcript)|ensembl:ENST00000612450(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q5SW79|rcsb pdb:4JON|refseq:XP_016858425.1|dip:DIP-37594N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:gEJsUZqeO9zpm94iMzIAUvsUbqc9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:17F849CF7E29A111|rigid:1VlMGH82pBhFebqaM9qMauwQL0k	false	sufficient binding region:1440-1584(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54725	uniprotkb:P52735	intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654558|imex:IM-13772-34	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:7C0BFAC42F4681E6|rigid:PJd4YXC8vRDszXAlWqAj/3vuTWQ	false	sufficient binding region:1-363(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5F1R6	uniprotkb:P52735	intact:EBI-2654581|uniprotkb:Q86VC6|uniprotkb:Q3B7J9|uniprotkb:Q6P086|uniprotkb:Q6ZS43|ensembl:ENSP00000497410	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:djc21_human(display_long)|uniprotkb:DNAJA5(gene name synonym)|uniprotkb:DnaJ homolog subfamily A member 5(gene name synonym)|uniprotkb:Protein GS3(gene name synonym)|uniprotkb:DNAJC21(gene name)|psi-mi:DNAJC21(display_short)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654578|imex:IM-13772-35	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012339.2|refseq:NP_919259.3|refseq:NP_001335349.1|ensembl:ENSG00000168724(gene)|ensembl:ENST00000648817(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR018253|interpro:IPR022755|interpro:IPR036236|interpro:IPR036869	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:kOjj8q0FAli0WuhVABPuV8nGsRg9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:4251DE875299B4E7|rigid:BFFNDa+PlkJuS1sPk5d5xlENtME	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52597	uniprotkb:P52735	intact:EBI-352986|ensembl:ENSP00000338477|ensembl:ENSP00000349573|ensembl:ENSP00000400433|ensembl:ENSP00000438061|ensembl:ENSP00000507787|ensembl:ENSP00000348345|uniprotkb:Q5T0N2|uniprotkb:Q96AU2|uniprotkb:B3KM84	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:hnrpf_human(display_long)|uniprotkb:HNRNPF(gene name)|psi-mi:HNRNPF(display_short)|uniprotkb:HNRPF(gene name synonym)|uniprotkb:Nucleolin-like protein mcs94-1(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654568|imex:IM-13772-79	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P52597|rcsb pdb:2HGL|rcsb pdb:2HGM|rcsb pdb:2HGN|rcsb pdb:2KFY|rcsb pdb:2KG0|rcsb pdb:2KG1|rcsb pdb:3TFY|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|ensembl:ENSG00000169813(gene)|ensembl:ENST00000337970(transcript)|ensembl:ENST00000356053(transcript)|ensembl:ENST00000357065(transcript)|ensembl:ENST00000443950(transcript)|ensembl:ENST00000544000(transcript)|ensembl:ENST00000682386(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001091674.1|refseq:NP_001091675.1|refseq:NP_001091676.1|refseq:NP_001091677.1|refseq:NP_001091678.1|refseq:NP_004957.1|dip:DIP-33145N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:pblzpldZOa5vlZ+zGQY9qyWCxaw9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:39C8D9AB969B7006|rigid:zhLLJrz11TIgElt44h4qBHrqyUc	false	sufficient binding region:56-415(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q8WZ42	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-681210|intact:EBI-1384264|intact:EBI-1058389|intact:EBI-28975411|intact:EBI-2562129|ensembl:ENSP00000465570|intact:EBI-3448943|uniprotkb:Q4ZG20|uniprotkb:Q10465|uniprotkb:Q10466|uniprotkb:Q15598|uniprotkb:Q2XUS3|uniprotkb:Q32Q60|uniprotkb:Q4U1Z6|uniprotkb:Q6NSG0|uniprotkb:Q6PDB1|uniprotkb:Q6PJP0|uniprotkb:Q7KYM2|uniprotkb:Q7KYN4|uniprotkb:Q7KYN5|uniprotkb:Q7LDM3|uniprotkb:Q7Z2X3|uniprotkb:Q8TCG8|uniprotkb:Q8WZ51|uniprotkb:Q8WZ52|uniprotkb:Q8WZ53|uniprotkb:Q8WZB3|uniprotkb:Q92761|uniprotkb:Q92762|uniprotkb:Q9UD97|uniprotkb:Q9UP84|uniprotkb:Q9Y6L9|uniprotkb:A6NKB1|uniprotkb:E7EQE6|uniprotkb:E7ET18|uniprotkb:K7ENY1	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:titin_human(display_long)|uniprotkb:TTN(gene name)|psi-mi:TTN(display_short)|uniprotkb:Connectin(gene name synonym)|uniprotkb:Rhabdomyosarcoma antigen MU-RMS-40.14(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654593|imex:IM-13772-80	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_001243779.1|refseq:NP_596869.4|refseq:NP_597676.3|refseq:NP_003310.4|ensembl:ENSG00000155657(gene)|ensembl:ENST00000591111(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002020"(protease binding)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0031430"(M band)|go:"GO:0031433"(telethonin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097493"(structural molecule activity conferring elasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|ensembl:ENST00000342992|ensembl:ENSP00000343764|ensembl:ENST00000359218|ensembl:ENSP00000352154|ensembl:ENST00000360870|ensembl:ENSP00000354117|ensembl:ENST00000460472|ensembl:ENSP00000434586|ensembl:ENSP00000465570|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR004168(PPAK motif)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015129(Titin Z)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q8WZ42|rcsb pdb:1BPV|rcsb pdb:1G1C|rcsb pdb:1NCT|rcsb pdb:1NCU|rcsb pdb:1TIT|rcsb pdb:1TIU|rcsb pdb:1TKI|rcsb pdb:1TNM|rcsb pdb:1TNN|rcsb pdb:1WAA|rcsb pdb:1YA5|rcsb pdb:2BK8|rcsb pdb:2F8V|rcsb pdb:2ILL|rcsb pdb:2J8H|rcsb pdb:2A38|rcsb pdb:2J8O|rcsb pdb:2NZI|rcsb pdb:2RQ8|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:2Y9R|rcsb pdb:3B43|rcsb pdb:3KNB|rcsb pdb:3LCY|rcsb pdb:3LPW|rcsb pdb:3PUC|rcsb pdb:3Q5O|rcsb pdb:3QP3|rcsb pdb:4C4K|rcsb pdb:4JNW|rcsb pdb:4O00|rcsb pdb:4UOW|rcsb pdb:5BS0|rcsb pdb:5JDD|rcsb pdb:5JDE|rcsb pdb:5JDJ|rcsb pdb:5JOE|rcsb pdb:6DL4|rcsb pdb:6H4L|rcsb pdb:4QEG|rcsb pdb:6HCI|rcsb pdb:6I0Y|rcsb pdb:6SDB|rcsb pdb:6YGN|rcsb pdb:7AHS|rcsb pdb:7NIP|reactome:R-HSA-114608|reactome:R-HSA-390522|refseq:NP_596870.2|dip:DIP-33449N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:wnuQ0Js5X0a3F1wHb7EBSHLhgvo9606	intact-crc:3219D8201092C074|rigid:x5Cg5yUrnYtjZhAtWo5InanJLHI	false	-	sufficient binding region:10559-12059(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92564	uniprotkb:P52735	intact:EBI-2654610|uniprotkb:Q7Z6B8|uniprotkb:Q7Z3F3|uniprotkb:B4DH25|ensembl:ENSP00000334625	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:dcnl4_human(display_long)|uniprotkb:KIAA0276(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 4(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 4(gene name synonym)|uniprotkb:DCUN1D4(gene name)|psi-mi:DCUN1D4(display_short)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654616|imex:IM-13772-81	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035492.1|refseq:NP_055930.2|refseq:NP_001274684.1|refseq:NP_001274686.1|ensembl:ENSG00000109184(gene)|ensembl:ENST00000334635(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:5V89|reactome:R-HSA-8951664|interpro:IPR005176(Protein of unknown function DUF298)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:/f04gSz7Ckwo7uvdg6WFkAvgdyY9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:F329E8CE4720FB57|rigid:x31BzATFUhH+xn2qEuCT7ThjkdA	false	sufficient binding region:9-292(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49368	uniprotkb:P52735	intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654603|imex:IM-13772-36	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:29A540D80862BEBD|rigid:shafXFMvLK7Ug1loBUOCsdKGP5g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6E0	uniprotkb:P52735	intact:EBI-740175|uniprotkb:O14840|ensembl:ENSP00000365730|uniprotkb:Q5JV92|intact:EBI-1054809	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:stk24_human(display_long)|uniprotkb:STK24(gene name)|psi-mi:STK24(display_short)|uniprotkb:MST3(gene name synonym)|uniprotkb:STK3(gene name synonym)|uniprotkb:STE20-like kinase MST3(gene name synonym)|uniprotkb:Mammalian STE20-like protein kinase 3(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654626|imex:IM-13772-37	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102572(gene)|ensembl:ENST00000376547(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0045296"(cadherin binding)|refseq:NP_001027467.2|refseq:NP_003567.2|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3A7F|rcsb pdb:3A7G|rcsb pdb:3A7H|rcsb pdb:3A7I|rcsb pdb:3A7J|rcsb pdb:3CKW|rcsb pdb:3CKX|rcsb pdb:3ZHP|rcsb pdb:4O27|rcsb pdb:4QML|rcsb pdb:4QMM|rcsb pdb:4QMN|rcsb pdb:4QMO|rcsb pdb:4QMP|rcsb pdb:4QMQ|rcsb pdb:4QMS|rcsb pdb:4QMT|rcsb pdb:4QMU|rcsb pdb:4QMV|rcsb pdb:4QMW|rcsb pdb:4QMX|rcsb pdb:4QMY|rcsb pdb:4QMZ|rcsb pdb:4QNA|rcsb pdb:4QO9|rcsb pdb:4U8Z|rcsb pdb:4W8D|rcsb pdb:4W8E|rcsb pdb:7B30|rcsb pdb:7B31|rcsb pdb:7B32|rcsb pdb:7B33|rcsb pdb:7B34|rcsb pdb:7B35|reactome:R-HSA-111465|reactome:R-HSA-75153|dip:DIP-40608N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:El6otOj/3rikTQX8EOIz3Eohgsw9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:875218CAD27A9E94|rigid:o68aNXFouz7tBnsCXZAvU1VKpSM	false	sufficient binding region:247-443(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:O75688	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-1047039|uniprotkb:Q9HAY8|uniprotkb:Q461Q2|uniprotkb:Q658R4|ensembl:ENSP00000282412|uniprotkb:Q96ER6|uniprotkb:Q4J6C1|uniprotkb:Q4J6C2	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:ppm1b_human(display_long)|uniprotkb:Protein phosphatase 2C isoform beta(gene name synonym)|uniprotkb:PPM1B(gene name)|psi-mi:PPM1B(display_short)|uniprotkb:PP2CB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654646|imex:IM-13772-38	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_001028729.1|refseq:NP_002697.1|refseq:NP_808907.1|refseq:NP_808908.1|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|interpro:IPR036457|interpro:IPR036580|mint:O75688|rcsb pdb:2P8E|reactome:R-HSA-1169408|ensembl:ENSG00000138032(gene)|ensembl:ENST00000282412(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0016020"(membrane)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:cwwfGSSTv9pR/XNLa9UxQ/6hpD89606	intact-crc:010562198DCD6712|rigid:lxJCD+dNdWKxhxgmSZ2HNcd9nbo	false	-	sufficient binding region:89-479(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WUB8	uniprotkb:P52735	intact:EBI-716462|uniprotkb:Q2YDA3|uniprotkb:Q9BXD2|uniprotkb:Q53HG8|uniprotkb:Q9NV26|ensembl:ENSP00000341805	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:phf10_human(display_long)|uniprotkb:XAP135(gene name synonym)|uniprotkb:PHF10(gene name)|psi-mi:PHF10(display_short)|uniprotkb:BAF45A(gene name synonym)|uniprotkb:BRG1-associated factor 45a(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654636|imex:IM-13772-82	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060758.2|refseq:NP_579866.2|ensembl:ENSG00000130024(gene)|ensembl:ENST00000339209(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0071564"(npBAF complex)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR038045|mint:Q8WUB8	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:QppOFkomM0Lm/7EjW4Fov8NhB049606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:917BE4B9ECA7CA3E|rigid:c8a1t8RjEj4WRodliKLenODDtMk	false	sufficient binding region:89-498(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y4X5	uniprotkb:P52735	intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654656|imex:IM-13772-83	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:B45AD165E6F9D33D|rigid:kopwol7LpzYVXCPKW+19l1YAS6Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78362	uniprotkb:P52735	intact:EBI-593303|uniprotkb:A8MVX2|uniprotkb:O75220|uniprotkb:O75221|uniprotkb:Q6NUL0|uniprotkb:Q6V1X2|uniprotkb:Q8IYQ3|ensembl:ENSP00000349863|ensembl:ENSP00000419791	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:srpk2_human(display_long)|uniprotkb:Serine/arginine-rich protein-specific kinase 2(gene name synonym)|uniprotkb:SFRS protein kinase 2(gene name synonym)|uniprotkb:SRPK2(gene name)|psi-mi:SRPK2(display_short)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654670|imex:IM-13772-84	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_872633.1|refseq:NP_872634.1|refseq:NP_001265202.1|refseq:XP_016868055.1|ensembl:ENSG00000135250(gene)|ensembl:ENST00000357311(transcript)|ensembl:ENST00000489828(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000785"(chromatin)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2X7G|rcsb pdb:5MYV	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:dwIEunDCbmP7D/TZsXuoywX6o8U9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:11FB09A99379943A|rigid:AWBnshbhHxLXnGeevvWiM0/OuBg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52735	uniprotkb:Q9NR09	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-1765160|uniprotkb:Q9ULD1|ensembl:ENSP00000393596	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:birc6_human(display_long)|uniprotkb:BIRC6(gene name)|psi-mi:BIRC6(display_short)|uniprotkb:KIAA1289(gene name synonym)|uniprotkb:Ubiquitin-conjugating BIR domain enzyme apollon(gene name synonym)|uniprotkb:BIR repeat-containing ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654663|imex:IM-13772-39	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	refseq:NP_057336.3|ensembl:ENSG00000115760(gene)|ensembl:ENST00000421745(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051301"(cell division)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0090543"(Flemming body)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR022103|mint:Q9NR09|rcsb pdb:3CEG	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:/EZap+9dFkEnO5fRsbzriORwllk9606	intact-crc:7FB1DE9D87752695|rigid:0CxZPiu8KcxMhw8o+KNLHys0H/w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75575	uniprotkb:P52735	intact:EBI-2654687|uniprotkb:Q8IXL4|uniprotkb:Q3KRA3|uniprotkb:A8MW23|uniprotkb:B2R4H4|intact:EBI-2855843|uniprotkb:Q5HYF1|uniprotkb:B4E198|intact:EBI-28977752|ensembl:ENSP00000378736|uniprotkb:A8MUZ4	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:rpc9_human(display_long)|uniprotkb:Calcitonin gene-related peptide-receptor component protein(gene name synonym)|uniprotkb:CRCP(gene name)|psi-mi:CRCP(display_short)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654696|imex:IM-13772-85	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035738.1|ensembl:ENST00000338592|ensembl:ENSP00000340044|ensembl:ENSP00000378736|ensembl:ENST00000398684|ensembl:ENSP00000381674|ensembl:ENST00000431089|ensembl:ENSP00000388653|refseq:NP_001035737.1|refseq:NP_055293.1|refseq:NP_001135886.1|ensembl:ENSG00000241258(gene)|ensembl:ENST00000395326(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001635"(calcitonin gene-related peptide receptor activity)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR005574(RNA polymerase II, Rpb4)|interpro:IPR006590(RNA polymerase II, Rpb4, core)|interpro:IPR010997(HRDC-like)|interpro:IPR038324|interpro:IPR038846|mint:O75575|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:Xrb72g8eT2zV3NAFFyJXEBrloro9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:4EBBE2DC60A79139|rigid:1vTP9RsPqPEIU2ncVevS4BXLBys	false	sufficient binding region:1-148(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78371	uniprotkb:P52735	intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654677|imex:IM-13772-40	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:3E64E19D33D6E5E5|rigid:mc5uIYzwH5pcvaDxLXaQrwa+AQ0	false	sufficient binding region:39-535(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94868	uniprotkb:P55072	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654706|imex:IM-13772-41	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	intact-crc:7CFB7CE1402A48B8|rigid:a4KljVGXYtNQozNSLQBWlhYatPM	false	-	sufficient binding region:598-806(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94868	uniprotkb:P11021	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654726|imex:IM-13772-42	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	intact-crc:9565DF56B8A0DE27|rigid:o0LScg+MlLVm2Ysv67ttgA/NXLw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94868	uniprotkb:Q96JH7	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654716|imex:IM-13772-86	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606	intact-crc:DBCFBF96E5DA9086|rigid:ATaOIaAisAP0B5nQftX9ZHetwxA	false	-	sufficient binding region:876-1222(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96G28	uniprotkb:O94868	intact:EBI-2654750|uniprotkb:Q53ST9|uniprotkb:Q6UY34|uniprotkb:Q53SF0|intact:EBI-28976235|ensembl:ENSP00000295117	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	psi-mi:cfa36_human(display_long)|uniprotkb:CFAP36(gene name)|psi-mi:CFAP36(display_short)|uniprotkb:CCDC104(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 104(gene name synonym)|uniprotkb:UNQ163/PRO189(orf name)	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654747|imex:IM-13772-43	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269690.1|ensembl:ENST00000339012|ensembl:ENSP00000342699|ensembl:ENSP00000295117|refseq:NP_542398.3|ensembl:ENSG00000163001(gene)|ensembl:ENST00000349456(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005930"(axoneme)|go:"GO:0031514"(motile cilium)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0097546"(ciliary base)|interpro:IPR023379|interpro:IPR038888|interpro:IPR042541|dip:DIP-57013N	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:JQO4Xpav6rJoF1SOfxInk5Fuibk9606	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	intact-crc:F8F96096B7FD2837|rigid:7W/WTw4VXle91QzHC0+J7xKLTJA	false	sufficient binding region:55-342(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94868	uniprotkb:O76094	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	intact:EBI-1058850|ensembl:ENSP00000495128|intact:EBI-2654733|uniprotkb:G5E9Z8|uniprotkb:Q7Z3C0	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:srp72_human(display_long)|uniprotkb:SRP72(gene name)|psi-mi:SRP72(display_short)|uniprotkb:Signal recognition particle 72 kDa protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654737|imex:IM-13772-87	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	refseq:NP_008878.3|refseq:NP_001254651.1|ensembl:ENSG00000174780(gene)|ensembl:ENST00000642900(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0048500"(signal recognition particle)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013699(Signal recognition particle, SRP72 subunit, RNA-binding)|interpro:IPR019734|interpro:IPR026270|interpro:IPR031545|mint:O76094|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:5WRW|rcsb pdb:7NFX|reactome:R-HSA-1799339	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	rogid:NJfyOcmKiBWszQsH0EQotsdwhU09606	intact-crc:5311251840081D46|rigid:PFp+sae0rLLpPVSqh0BveOYjgpg	false	-	sufficient binding region:12-671	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N5S3	uniprotkb:O94868	intact:EBI-2653898|uniprotkb:Q8N7V4|uniprotkb:A0AV81|uniprotkb:A0AV79|ensembl:ENSP00000381631	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	psi-mi:cb073_human(display_long)|uniprotkb:C2orf73(gene name)|psi-mi:C2orf73(display_short)	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654764|imex:IM-13772-88	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530812.1|refseq:XP_011530815.1|refseq:NP_001093866.1|refseq:XP_005264190.1|refseq:XP_005264191.1|ensembl:ENSG00000177994(gene)|ensembl:ENST00000398634(transcript)|interpro:IPR031365	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:OVQ/WeSczVdPEVSIFjsRs+rtP/c9606	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	intact-crc:846FB5DED8C3CC59|rigid:1XLnqtO5Z/RizAO+MUAqm1TcBJk	false	sufficient binding region:1-166(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94868	uniprotkb:Q68DK7	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	intact:EBI-2560816|ensembl:ENSP00000381543|uniprotkb:Q69Z03|uniprotkb:Q0VF46|intact:EBI-2654071	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:msl1_human(display_long)|uniprotkb:MSL1(gene name)|psi-mi:MSL1(display_short)|uniprotkb:MSL1L1(gene name synonym)|uniprotkb:Male-specific lethal 1-like 1(gene name synonym)|uniprotkb:Male-specific lethal-1 homolog 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654774|imex:IM-13772-44	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	ensembl:ENSG00000188895(gene)|ensembl:ENST00000398532(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0072487"(MSL complex)|interpro:IPR026711|interpro:IPR029332|interpro:IPR031840|mint:Q68DK7|rcsb pdb:4B7Y|rcsb pdb:4B86|rcsb pdb:4DNC|reactome:R-HSA-3214847|refseq:NP_001012241.1|refseq:XP_005257355.1|dip:DIP-56862N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	rogid:sFenPEZNoGtpn1bDFoUzSJBPUBY9606	intact-crc:16C3D909BE4FCB9F|rigid:hShTDPTbgt11mfmRsM8UsMm0Mno	false	-	sufficient binding region:1-351(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94868	uniprotkb:P55822	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	intact:EBI-2654794|uniprotkb:Q9BRB8|uniprotkb:D3DSI2|uniprotkb:A6ND59	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:sh3bg_human(display_long)|uniprotkb:21-glutamic acid-rich protein(gene name synonym)|uniprotkb:SH3BGR(gene name)|psi-mi:SH3BGR(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654799|imex:IM-13772-45	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	refseq:NP_001001713.1|refseq:NP_031367.1|interpro:IPR006993(SH3-binding, glutamic acid-rich protein)|refseq:NP_001304671.1|go:"GO:0005829"(cytosol)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR036249	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	rogid:y87BaaAqqQpiYxSaBhlQk6pYgDs9606	intact-crc:E193BDB354B14B7C|rigid:lrRfPB6Z0lElZQHzZddbHZuRhCk	false	-	sufficient binding region:79-239(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78371	uniprotkb:O94868	intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym)	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654784|imex:IM-13772-89	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	intact-crc:FF332B4A3067E0FC|rigid:vlB3I5jfF81/n+8z7fxlenJ7iqA	false	sufficient binding region:9-535(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35790	uniprotkb:O94868	intact:EBI-2654809|uniprotkb:Q8NE29|ensembl:ENSP00000265689	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	psi-mi:chka_human(display_long)|uniprotkb:CHK(gene name synonym)|uniprotkb:CKI(gene name synonym)|uniprotkb:CHETK-alpha(gene name synonym)|uniprotkb:CHKA(gene name)|psi-mi:CHKA(display_short)|uniprotkb:Ethanolamine kinase(gene name synonym)	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654814|imex:IM-13772-90	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001268.2|refseq:NP_997634.1|ensembl:ENSG00000110721(gene)|ensembl:ENST00000265689(transcript)|go:"GO:0004103"(choline kinase activity)|go:"GO:0004104"(cholinesterase activity)|go:"GO:0004305"(ethanolamine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006580"(ethanolamine metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0019695"(choline metabolic process)|go:"GO:0033265"(choline binding)|go:"GO:0042802"(identical protein binding)|go:"GO:1904681"(response to 3-methylcholanthrene)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2CKO|rcsb pdb:2CKP|rcsb pdb:2CKQ|rcsb pdb:2I7Q|rcsb pdb:3F2R|rcsb pdb:3G15|rcsb pdb:3ZM9|rcsb pdb:4BR3|rcsb pdb:4CG8|rcsb pdb:4CG9|rcsb pdb:4CGA|rcsb pdb:4DA5|rcsb pdb:5AFV|rcsb pdb:5EQE|rcsb pdb:5EQP|rcsb pdb:5EQY|rcsb pdb:5FTG|rcsb pdb:5FUT|rcsb pdb:5W6O|rcsb pdb:7A04|rcsb pdb:7A06|reactome:R-HSA-1483191|reactome:R-HSA-1483213	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:hjKraV4IMsla7ZGrWj6ZR41eEoU9606	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	intact-crc:5919D02995EAF8CD|rigid:BuF8yLu1qWCCmky0IJbtathDlbo	false	sufficient binding region:116-457(IPR001452)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94868	uniprotkb:P08238	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654834|imex:IM-13772-91	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	rogid:wOsW7C10v2oMsM+REE38K6PAan09606	intact-crc:A13EE0F76CC0E11A|rigid:Q5toO/rXHzI23lmvHdjypV6Pl/s	false	-	sufficient binding region:458-724(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94868	uniprotkb:Q9NZ63	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	intact:EBI-2557577|uniprotkb:Q9NT39|uniprotkb:Q8WVU6|uniprotkb:B3KPX8|ensembl:ENSP00000361524	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:tls1_human(display_long)|uniprotkb:C9orf78(gene name)|psi-mi:C9orf78(display_short)|uniprotkb:HCA59(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 59(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2654824|imex:IM-13772-46	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	refseq:NP_057604.1|ensembl:ENSG00000136819(gene)|ensembl:ENST00000372447(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|interpro:IPR010756(Hepatocellular carcinoma-associated antigen 59)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	rogid:1ypLqEYpSrrqHknZqoOuZCn3NPA9606	intact-crc:A31D5CF097EA77C1|rigid:+HpDoB7R+5FGwhR5jZmDkWD3obc	false	-	sufficient binding region:200-289(IPR001452)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22736	uniprotkb:Q9Y5K6	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652572|imex:IM-13772-100	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	intact-crc:4EDB34B07A475F04|rigid:KVtdq97dxa8j3DSqsUmnP7Q74yc	false	sufficient binding region:67-598(IPR001452)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y5K6	uniprotkb:P49116	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	intact:EBI-2652582|uniprotkb:A8K3H5|uniprotkb:P55092|uniprotkb:B6ZGT8|ensembl:ENSP00000376814|ensembl:ENSP00000384463|ensembl:ENSP00000388387	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:nr2c2_human(display_long)|uniprotkb:NR2C2(gene name)|psi-mi:NR2C2(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:TR4(gene name synonym)|uniprotkb:Orphan nuclear receptor TR4(gene name synonym)|uniprotkb:Testicular receptor 4(gene name synonym)|uniprotkb:Orphan nuclear receptor TAK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652612|imex:IM-13772-98	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	refseq:NP_003289.2|refseq:NP_001278623.1|ensembl:ENSG00000177463(gene)|ensembl:ENST00000393102(transcript)|ensembl:ENST00000406272(transcript)|ensembl:ENST00000425241(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048856"(anatomical structure development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P49116|rcsb pdb:3P0U|reactome:R-HSA-383280|refseq:XP_016862609.1|dip:DIP-5999N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	rogid:FQqhbuxItvCQ2iu5nydvHZaNog89606	intact-crc:86B782B695C13105|rigid:V6OEn3Tt7SZwtxB+96qx3LZWbuU	false	-	sufficient binding region:85-596	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y5K6	uniprotkb:O60381	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	intact:EBI-954175|ensembl:ENSP00000222574|ensembl:ENSP00000418738|ensembl:ENSP00000420500|ensembl:ENSP00000491311|ensembl:ENSP00000492167|ensembl:ENSP00000492343|uniprotkb:Q8TBM1|uniprotkb:Q8TE93|uniprotkb:Q96AJ2|uniprotkb:B3KVB7	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:hbp1_human(display_long)|uniprotkb:HMG box transcription factor 1(gene name synonym)|uniprotkb:High mobility group box transcription factor 1(gene name synonym)|uniprotkb:HBP1(gene name)|psi-mi:HBP1(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652620|imex:IM-13772-99	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	ensembl:ENSG00000105856(gene)|ensembl:ENSG00000283847(gene)|ensembl:ENST00000222574(transcript)|ensembl:ENST00000468410(transcript)|ensembl:ENST00000485846(transcript)|ensembl:ENST00000638303(transcript)|ensembl:ENST00000638893(transcript)|ensembl:ENST00000640195(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR003652(Ataxin, AXH region)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036096|interpro:IPR036910|interpro:IPR039655|rcsb pdb:2E6O|rcsb pdb:3QVE|refseq:NP_036389.2|refseq:NP_001231191.1|refseq:XP_005250323.1|refseq:XP_005250324.1|refseq:XP_016867456.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	rogid:w0Y0uk7CSIHtVWindV1UDg04WBA9606	intact-crc:D2EACF0E0A67282B|rigid:3Ku3/U7R3cxnvr/7ejWdHGo1k7E	false	-	sufficient binding region:176-514(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y5K6	uniprotkb:O43248	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	intact:EBI-2652631|uniprotkb:A8K7D1|uniprotkb:Q96DH2|ensembl:ENSP00000446680	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:hxc11_human(display_long)|uniprotkb:HOXC11(gene name)|psi-mi:HOXC11(display_short)|uniprotkb:HOX3H(gene name synonym)|uniprotkb:Homeobox protein Hox-3H(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652655|imex:IM-13772-97	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	refseq:NP_055027.1|ensembl:ENSG00000123388(gene)|ensembl:ENST00000546378(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048856"(anatomical structure development)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR017970|interpro:IPR020479|interpro:IPR021918	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	rogid:G3nt4+imve6xwS8vB4oTwzFv4MA9606	intact-crc:DA14FCF542159A78|rigid:0RWQuiYGOE3+6Tbua8L0p9k4cmQ	false	-	sufficient binding region:133-304(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46109	intact:EBI-2652663	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	-	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:a6ncg8_human(display_short)|psi-mi:EBI-2652663(display_long)|uniprotkb:LTBP4(gene name)|psi-mi:LTBP4(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652681|imex:IM-13772-105	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	uniprotkb:A6NCG8(uniprot-removed-ac)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:ijxIs3kWI1/8K8DQtCef5QbhThM9606	intact-crc:212CBE699B2E3659|rigid:xoz/eHjNK9ZKytcy6AtWREyVqQg	false	-	sufficient binding region:360-1420(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46109	uniprotkb:P28799	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652689|imex:IM-13772-106	author score:low	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	intact-crc:8C1D2E8A81EBFF0F|rigid:VQknIptXgyzaJBE6LXCu8yL1Rlg	false	-	sufficient binding region:151-593(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46109	uniprotkb:O15162	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-740019|ensembl:ENSP00000345494|uniprotkb:B2R8H8|uniprotkb:B4DTE8	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:pls1_human(display_long)|uniprotkb:PLSCR1(gene name)|psi-mi:PLSCR1(display_short)|uniprotkb:"Ca(2+)-dependent phospholipid scramblase 1"(gene name synonym)|uniprotkb:Erythrocyte phospholipid scramblase(gene name synonym)|uniprotkb:MmTRA1b(gene name synonym)|uniprotkb:"Mg(2+)-dependent nuclease"(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652697|imex:IM-13772-104	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	ensembl:ENSG00000188313(gene)|ensembl:ENST00000342435(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001618"(virus receptor activity)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006659"(phosphatidylserine biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0017124"(SH3 domain binding)|ensembl:ENSP00000345494|ensembl:ENST00000448787|ensembl:ENSP00000411675|refseq:NP_066928.1|go:"GO:0017128"(phospholipid scramblase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0032791"(lead ion binding)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051607"(defense response to virus)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070782"(phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1905820"(positive regulation of chromosome separation)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|interpro:IPR005552(Scramblase)|mint:O15162|rcsb pdb:1Y2A|refseq:XP_011511209.1|refseq:XP_011511206.1|refseq:XP_005247595.1|refseq:XP_011511208.1|refseq:XP_016862118.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:XudfvUkrZbB28t9tpFkokgnDFGc9606	intact-crc:AEEBE00BCC20A186|rigid:ty3lpg1eBGMxXED/q9i1+x/RXzo	false	-	sufficient binding region:66-318(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46109	uniprotkb:O15230	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-725060|uniprotkb:Q8WZA7|uniprotkb:Q9H1P1|uniprotkb:Q8TDF8|uniprotkb:Q5U4N9|ensembl:ENSP00000252999	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:lama5_human(display_long)|uniprotkb:LAMA5(gene name)|psi-mi:LAMA5(display_short)|uniprotkb:KIAA0533(gene name synonym)|uniprotkb:KIAA1907(gene name synonym)|uniprotkb:Laminin-10 subunit alpha(gene name synonym)|uniprotkb:Laminin-11 subunit alpha(gene name synonym)|uniprotkb:Laminin-15 subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652725|imex:IM-13772-107	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	refseq:NP_005551.3|ensembl:ENSG00000130702(gene)|ensembl:ENST00000252999(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001942"(hair follicle development)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005610"(laminin-5 complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007517"(muscle organ development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016477"(cell migration)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0043260"(laminin-11 complex)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0060271"(cilium assembly)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR001791(Laminin G)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR009254(Laminin I)|interpro:IPR010307(Laminin II)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:O15230|rcsb pdb:5XAU|rcsb pdb:7CEC|reactome:R-HSA-1474228|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-6785807|reactome:R-HSA-8874081	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:rSTl5zwwQKcbd20buKGffFtl3jI9606	intact-crc:B14758D108B7354C|rigid:mgJ5ygqO8UvK5QKKoAdLaIbKKqA	false	-	sufficient binding region:545-3695(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46109	uniprotkb:Q04721	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-2652733|uniprotkb:Q5T3X7|uniprotkb:Q99734|uniprotkb:Q9H240|ensembl:ENSP00000256646	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:notc2_human(display_long)|uniprotkb:NOTCH2(gene name)|psi-mi:NOTCH2(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652783|imex:IM-13772-109	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	refseq:NP_001186930.1|refseq:NP_077719.2|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046849"(bone remodeling)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:1990705"(cholangiocyte proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001204"(regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0035622"(intrahepatic bile duct development)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022336|interpro:IPR010660(Notch, NOD region)|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q04721|rcsb pdb:2OO4|rcsb pdb:5MWB|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-2197563|reactome:R-HSA-2979096|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-9013695|ensembl:ENSG00000134250(gene)|ensembl:ENST00000256646(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035264"(multicellular organism growth)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:aXdQSGMwNJ7K0tA2kc3rRFysbIc9606	intact-crc:4CC2B6053E7A6D7C|rigid:PXMJKuyoQMYne+ZpVDpkJIuiKmY	false	-	sufficient binding region:26-2471(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75095	uniprotkb:P46109	intact:EBI-947597|uniprotkb:Q5VV39|uniprotkb:Q4AC86|ensembl:ENSP00000348982	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:megf6_human(display_long)|uniprotkb:MEGF6(gene name)|psi-mi:MEGF6(display_short)|uniprotkb:EGFL3(gene name synonym)|uniprotkb:KIAA0815(gene name synonym)|uniprotkb:Epidermal growth factor-like protein 3(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652791|imex:IM-13772-110	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001400.3|ensembl:ENSG00000162591(gene)|ensembl:ENST00000356575(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|mint:O75095	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:/4HcLiv4UEW2qmvoV2OTj110y1I9606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:32279FE26B05C4DC|rigid:gIR0npjNlv7CDn6vI7WifYX0Lv4	false	sufficient binding region:728-1229(IPR001452)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BU70	uniprotkb:Q99469	intact:EBI-2652818|uniprotkb:Q5T113|uniprotkb:Q86SK0|uniprotkb:Q9NXJ7|uniprotkb:Q9P0Q7|ensembl:ENSP00000364260	intact:EBI-2652799|uniprotkb:B2R8S8|ensembl:ENSP00000273183	psi-mi:trmo_human(display_long)|uniprotkb:TRMO(gene name)|psi-mi:TRMO(display_short)|uniprotkb:C9orf156(gene name synonym)|uniprotkb:tRNA methyltransferase O(gene name synonym)|uniprotkb:HSPC219(orf name)	psi-mi:stac_human(display_long)|uniprotkb:STAC(gene name)|psi-mi:STAC(display_short)|uniprotkb:Src homology 3 and cysteine-rich domain-containing protein(gene name synonym)|uniprotkb:STAC1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652835|imex:IM-13772-108	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057565.3|refseq:NP_001317654.1|ensembl:ENSG00000136932(gene)|ensembl:ENST00000375119(transcript)|go:"GO:0016430"("tRNA (adenine-N6-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR023368|interpro:IPR023370|interpro:IPR036413|interpro:IPR036414|interpro:IPR040372|mint:Q9BU70	refseq:NP_003140.1|ensembl:ENSG00000144681(gene)|ensembl:ENST00000273183(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030315"(T-tubule)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001452(Src homology-3)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR035508|interpro:IPR036028|interpro:IPR039688|mint:Q99469|rcsb pdb:2DL4|rcsb pdb:6B25	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:qwbZAAKb4hyf+f+ArhguFTqnMso9606	rogid:8RqTwCIcB04azYqRuxegTSYkVf09606	intact-crc:80D2D0EC7A56350E|rigid:ln1XnoIdhcDC8ejxLORPiQ7nscA	false	sufficient binding region:1-441(IPR001452)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99469	uniprotkb:Q15654	intact:EBI-2652799|uniprotkb:B2R8S8|ensembl:ENSP00000273183	intact:EBI-742327|uniprotkb:O15170|uniprotkb:O15275|uniprotkb:Q9BTB2|uniprotkb:Q9BUE5|uniprotkb:Q9BXP3|uniprotkb:Q9UNT4|uniprotkb:A4D2E7|ensembl:ENSP00000200457|uniprotkb:F2ZC07|uniprotkb:F2ZC08	psi-mi:stac_human(display_long)|uniprotkb:STAC(gene name)|psi-mi:STAC(display_short)|uniprotkb:Src homology 3 and cysteine-rich domain-containing protein(gene name synonym)|uniprotkb:STAC1(gene name synonym)	psi-mi:trip6_human(display_long)|uniprotkb:TRIP6(gene name)|psi-mi:TRIP6(display_short)|uniprotkb:OIP1(gene name synonym)|uniprotkb:Opa-interacting protein 1(gene name synonym)|uniprotkb:Zyxin-related protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652854|imex:IM-13772-101	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003140.1|ensembl:ENSG00000144681(gene)|ensembl:ENST00000273183(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030315"(T-tubule)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001452(Src homology-3)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR035508|interpro:IPR036028|interpro:IPR039688|mint:Q99469|rcsb pdb:2DL4|rcsb pdb:6B25	refseq:NP_003293.2|ensembl:ENSP00000200457|ensembl:ENST00000417475|ensembl:ENSP00000413817|ensembl:ENST00000437505|ensembl:ENSP00000410736|ensembl:ENST00000619988|ensembl:ENSP00000479865|ensembl:ENSG00000087077(gene)|ensembl:ENST00000200457(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q15654|rcsb pdb:1X61|rcsb pdb:2DLO|dip:DIP-34466N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:8RqTwCIcB04azYqRuxegTSYkVf09606	rogid:9Okf3b6sMMwX5awAx991GN9iSsQ9606	intact-crc:EF8A8DA70066BD3E|rigid:uO6kzz45J+lQL3uAo+NRPkFu/LU	false	-	sufficient binding region:95-476(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NZQ3	uniprotkb:Q99469	intact:EBI-745080|ensembl:ENSP00000294129|uniprotkb:B4DFL5|uniprotkb:Q6SPF3|uniprotkb:Q8TC10|uniprotkb:Q9UGM8|intact:EBI-957585|uniprotkb:Q6GU34	intact:EBI-2652799|uniprotkb:B2R8S8|ensembl:ENSP00000273183	psi-mi:spn90_human(display_long)|uniprotkb:NCKIPSD(gene name)|psi-mi:NCKIPSD(display_short)|uniprotkb:AF3P21(gene name synonym)|uniprotkb:SPIN90(gene name synonym)|uniprotkb:54 kDa VacA-interacting protein(gene name synonym)|uniprotkb:54 kDa vimentin-interacting protein(gene name synonym)|uniprotkb:90 kDa SH3 protein interacting with Nck(gene name synonym)|uniprotkb:AF3p21(gene name synonym)|uniprotkb:Dia-interacting protein 1(gene name synonym)|uniprotkb:Diaphanous protein-interacting protein(gene name synonym)|uniprotkb:SH3 adapter protein SPIN90(gene name synonym)|uniprotkb:WASP-interacting SH3-domain protein(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)	psi-mi:stac_human(display_long)|uniprotkb:STAC(gene name)|psi-mi:STAC(display_short)|uniprotkb:Src homology 3 and cysteine-rich domain-containing protein(gene name synonym)|uniprotkb:STAC1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652863|imex:IM-13772-102	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007010"(cytoskeleton organization)|ensembl:ENSG00000213672(gene)|ensembl:ENST00000294129(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006897"(endocytosis)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017022"(myosin binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0071933"(Arp2/3 complex binding)|interpro:IPR001452(Src homology-3)|interpro:IPR018556|interpro:IPR030125|interpro:IPR035514|interpro:IPR036028|mint:Q9NZQ3|refseq:NP_057537.1|refseq:NP_909119.1|rcsb pdb:6DEC|rcsb pdb:6DED|rcsb pdb:6DEE|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9664422	refseq:NP_003140.1|ensembl:ENSG00000144681(gene)|ensembl:ENST00000273183(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030315"(T-tubule)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001452(Src homology-3)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR035508|interpro:IPR036028|interpro:IPR039688|mint:Q99469|rcsb pdb:2DL4|rcsb pdb:6B25	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:GPUSFE2sszpigAuSg81Cmk7HJCM9606	rogid:8RqTwCIcB04azYqRuxegTSYkVf09606	intact-crc:1F29F45A397B47BE|rigid:LtFBJkq0asD6IhDrmhlLOmtJ0ME	false	sufficient binding region:1-722(IPR001452)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99469	uniprotkb:Q9UGP4	intact:EBI-2652799|uniprotkb:B2R8S8|ensembl:ENSP00000273183	intact:EBI-2652871|uniprotkb:Q17RQ1|uniprotkb:Q9BQQ9|uniprotkb:Q9NQ47|ensembl:ENSP00000273317	psi-mi:stac_human(display_long)|uniprotkb:STAC(gene name)|psi-mi:STAC(display_short)|uniprotkb:Src homology 3 and cysteine-rich domain-containing protein(gene name synonym)|uniprotkb:STAC1(gene name synonym)	psi-mi:limd1_human(display_long)|uniprotkb:LIMD1(gene name)|psi-mi:LIMD1(display_short)	psi-mi:"MI:0018"(two hybrid)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652891|imex:IM-13772-103	author score:high	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003140.1|ensembl:ENSG00000144681(gene)|ensembl:ENST00000273183(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030315"(T-tubule)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001452(Src homology-3)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR035508|interpro:IPR036028|interpro:IPR039688|mint:Q99469|rcsb pdb:2DL4|rcsb pdb:6B25	refseq:NP_055055.1|ensembl:ENSG00000144791(gene)|ensembl:ENST00000273317(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016310"(phosphorylation)|go:"GO:0016442"(RISC complex)|go:"GO:0016477"(cell migration)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028734|reactome:R-HSA-1234176	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/05/04	2014/10/16	rogid:8RqTwCIcB04azYqRuxegTSYkVf09606	rogid:Eq6aJ83PR4G/LIlUi5H2Bv31sTQ9606	intact-crc:47328272E3E8E464|rigid:Kv1q4c3qbAQz8TWDzhPxatSl2n8	false	-	sufficient binding region:34-676(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75674	uniprotkb:P52735	intact:EBI-712991|intact:EBI-28969677|ensembl:ENSP00000460823|uniprotkb:Q53G06|uniprotkb:Q8N749|uniprotkb:B7Z9E2	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:tm1l1_human(display_long)|uniprotkb:Target of Myb-like protein 1(gene name synonym)|uniprotkb:Src-activating and signaling molecule protein(gene name synonym)|uniprotkb:TOM1L1(gene name)|psi-mi:TOM1L1(display_short)|uniprotkb:SRCASM(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652935|imex:IM-13772-92	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141198(gene)|ensembl:ENST00000575882(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008942(ENTH/VHS)|interpro:IPR014645(Target of Myb protein 1)|interpro:IPR027428|mint:O75674|rcsb pdb:3RRU|interpro:IPR038425|refseq:NP_005477.2|ensembl:ENST00000348161|ensembl:ENSP00000343901|ensembl:ENST00000536554|ensembl:ENSP00000443099|ensembl:ENST00000570371|ensembl:ENSP00000458553|ensembl:ENST00000575333|ensembl:ENSP00000458918|ensembl:ENSP00000460823|refseq:NP_001308102.1|refseq:NP_001308103.1|refseq:NP_001308104.1|refseq:NP_001308105.1|refseq:XP_016879491.1	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N	psi-mi:"MI:0469"(intact)	-	-	figure legend:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/05/04	2014/10/16	rogid:JQewIcPaPAlc2CknMG3p45OWbhI9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:15B72D37229DEE5B|rigid:JdZB9pnIYy7PfttLU3PjbTNr2BA	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9ULV3	uniprotkb:Q9P0V3	intact:EBI-2652948|uniprotkb:Q9NYM8|uniprotkb:Q9UHK4|uniprotkb:Q9Y3F9|uniprotkb:Q9Y3G0|uniprotkb:Q5SYW5|uniprotkb:Q5SYW3|uniprotkb:Q8WU72|uniprotkb:Q9H868|uniprotkb:A8K9J8|ensembl:ENSP00000362029|ensembl:ENSP00000489425|uniprotkb:B4E131|uniprotkb:B7ZAS8	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	psi-mi:ciz1_human(display_long)|uniprotkb:CIZ1(gene name)|psi-mi:CIZ1(display_short)|uniprotkb:LSFR1(gene name synonym)|uniprotkb:NP94(gene name synonym)|uniprotkb:ZNF356(gene name synonym)|uniprotkb:CDKN1A-interacting zinc finger protein 1(gene name synonym)|uniprotkb:Nuclear protein NP94(gene name synonym)|uniprotkb:Zinc finger protein 356(gene name synonym)	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2652943|imex:IM-13772-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001124487.1|refseq:NP_001124488.1|refseq:NP_001124489.1|refseq:NP_001124490.1|refseq:NP_036259.2|refseq:XP_005251950.4|refseq:XP_006717102.2|refseq:NP_001244904.1|refseq:NP_001244905.1|ensembl:ENSG00000148337(gene)|ensembl:ENST00000372938(transcript)|ensembl:ENST00000634901(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR026811|interpro:IPR036236|go:"GO:0005886"(plasma membrane)|refseq:XP_005251945.2|refseq:XP_005251948.2|refseq:XP_016870085.1	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/05/04	2014/10/16	rogid:ZjDQwT+PexCvP7x2bIAZn9nYepc9606	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	intact-crc:045488407E30542D|rigid:VYA1gmeYZbqz6l5lh3Y9I9tX4yc	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9P0V3	uniprotkb:Q9HB21	intact:EBI-1049513|uniprotkb:O95082|uniprotkb:Q309A3|uniprotkb:Q53QD0|uniprotkb:Q53TD1|intact:EBI-28967532|ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862	intact:EBI-2652984|uniprotkb:Q9BVK0|uniprotkb:D3DRE2|uniprotkb:B3KQ55|ensembl:ENSP00000357986|ensembl:ENSP00000376547|ensembl:ENSP00000394416	psi-mi:sh3b4_human(display_long)|uniprotkb:Transferrin receptor-trafficking protein(gene name synonym)|uniprotkb:EH-binding protein 10(gene name synonym)|uniprotkb:SH3BP4(gene name)|psi-mi:SH3BP4(display_short)|uniprotkb:BOG25(gene name synonym)|uniprotkb:EHB10(gene name synonym)|uniprotkb:TTP(gene name synonym)	psi-mi:pkha1_human(display_long)|uniprotkb:PLEKHA1(gene name)|psi-mi:PLEKHA1(display_short)|uniprotkb:TAPP1(gene name synonym)|uniprotkb:Tandem PH domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653009|imex:IM-13772-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000340237|ensembl:ENSP00000375867|ensembl:ENSP00000386862|refseq:XP_011509193.1|refseq:XP_011509194.1|refseq:XP_011509195.1|refseq:XP_011509196.1|refseq:NP_055336.1|ensembl:ENSG00000130147(gene)|ensembl:ENST00000344528(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034260"(negative regulation of GTPase activity)|ensembl:ENST00000392011(transcript)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000409212(transcript)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR035455|interpro:IPR035456|interpro:IPR036028|mint:Q9P0V3|reactome:R-HSA-9639288	refseq:NP_001001974.1|refseq:NP_001182537.1|refseq:NP_067635.2|refseq:NP_001317107.1|refseq:XP_016871969.1|refseq:XP_016871970.1|refseq:XP_016871971.1|refseq:XP_016871979.1|refseq:XP_016871980.1|ensembl:ENSG00000107679(gene)|ensembl:ENST00000368990(transcript)|ensembl:ENST00000392799(transcript)|ensembl:ENST00000433307(transcript)|go:"GO:0001553"(luteinization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-HSA-1660499|rcsb pdb:1EAZ|refseq:XP_005270073.1|refseq:XP_005270078.1|ensembl:ENST00000368988|ensembl:ENSP00000357984|ensembl:ENSP00000357986|ensembl:ENSP00000376547|ensembl:ENSP00000394416	psi-mi:"MI:0469"(intact)	-	-	figure legend:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/05/04	2014/10/16	rogid:tCXIWMmxXloCTB14zNmKOqTjr8g9606	rogid:a4aD7YitZrTeGt2rr8x7+nikTlg9606	intact-crc:7B28D4DEE6C2DF63|rigid:61t19oDfKRBzIDgxikphsn3xo6A	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P55072	uniprotkb:O94868	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	intact:EBI-1215612|uniprotkb:Q7L8J9|uniprotkb:Q8WVM2|uniprotkb:Q96FV7|uniprotkb:Q9UF77|uniprotkb:B4DNI3|ensembl:ENSP00000386722	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:fcsd2_human(display_long)|uniprotkb:FCHSD2(gene name)|psi-mi:FCHSD2(display_short)|uniprotkb:KIAA0769(gene name synonym)|uniprotkb:SH3MD3(gene name synonym)|uniprotkb:Protein nervous wreck 1(gene name synonym)|uniprotkb:SH3 multiple domains protein 3(gene name synonym)|uniprotkb:Carom(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653025|imex:IM-13772-94	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N	refseq:NP_055639.2|ensembl:ENSG00000137478(gene)|ensembl:ENST00000409418(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0055037"(recycling endosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0120043"(stereocilium shaft)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR031160|interpro:IPR034934|interpro:IPR035460|interpro:IPR035556|interpro:IPR036028|rcsb pdb:2DL5|rcsb pdb:2DL7|rcsb pdb:6GBU	psi-mi:"MI:0469"(intact)	-	-	figure legend:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/05/04	2014/10/16	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	rogid:xFBlyK0IF2ilx10dexPnS/KVh+89606	intact-crc:D544AC7E15F1AFFA|rigid:a4KljVGXYtNQozNSLQBWlhYatPM	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NQY0	uniprotkb:Q6XZF7	intact:EBI-2653038|uniprotkb:Q9BVG2|uniprotkb:Q9NVY9|ensembl:ENSP00000276416	intact:EBI-2483419|ensembl:ENSP00000315659|uniprotkb:Q8IVY3|uniprotkb:Q9Y2L3	psi-mi:bin3_human(display_long)|uniprotkb:BIN3(gene name)|psi-mi:BIN3(display_short)	psi-mi:dnmbp_human(display_long)|uniprotkb:DNMBP(gene name)|psi-mi:DNMBP(display_short)|uniprotkb:KIAA1010(gene name synonym)|uniprotkb:Scaffold protein Tuba(gene name synonym)|uniprotkb:ARHGEF36(gene name synonym)|uniprotkb:TUBA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Thalappilly et al. (2008)	imex:IM-13772|pubmed:18654987	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2653033|imex:IM-13772-96	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011542888.1|refseq:NP_061158.1|ensembl:ENSG00000147439(gene)|ensembl:ENST00000276416(transcript)|go:"GO:0000917"(division septum assembly)|go:"GO:0005737"(cytoplasm)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008104"(protein localization)|go:"GO:0009826"(unidimensional cell growth)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051666"(actin cortical patch localization)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR037428	ensembl:ENSG00000107554(gene)|ensembl:ENST00000324109(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007568"(aging)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0098793"(presynapse)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035469|interpro:IPR035817|interpro:IPR035818|interpro:IPR035819|interpro:IPR035820|interpro:IPR035899|interpro:IPR036028|mint:Q6XZF7|rcsb pdb:1UG1|rcsb pdb:1UHC|rcsb pdb:4CC2|rcsb pdb:4CC3|rcsb pdb:4CC4|rcsb pdb:4CC7|rcsb pdb:4GLM|reactome:R-HSA-9013148|refseq:XP_011537861.1|refseq:NP_056036.1|refseq:NP_001305255.1|refseq:NP_001305256.1|dip:DIP-53822N	psi-mi:"MI:0469"(intact)	-	-	figure legend:2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/05/04	2014/10/16	rogid:BPnWqToFqQLXdT5NAUwZIZTraZY9606	rogid:Pnps+8tUGF35nxMUaPgDr5hzRzc9606	intact-crc:E4F3E92ED415711A|rigid:o5YWdtplw5MGy8R+1HoyRGk0xhU	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)