#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q55GF9 uniprotkb:Q54WX4 intact:EBI-922339|ensemblprotists:EAL73298 intact:EBI-2939723|ensemblprotists:EAL67820 psi-mi:icpa_dicdi(display_long)|uniprotkb:icpA(gene name)|psi-mi:icpA(display_short)|uniprotkb:Incenp(gene name synonym)|uniprotkb:DdINCENP(gene name synonym)|uniprotkb:DDB_G0267690(orf name) psi-mi:aurk_dicdi(display_long)|uniprotkb:aurK(gene name)|psi-mi:aurK(display_short)|uniprotkb:AurB(gene name synonym)|uniprotkb:Aurora(gene name synonym)|uniprotkb:DDB_G0279343(orf name) psi-mi:"MI:0096"(pull down) Li et al. (2008) pubmed:18326585|pubmed:18326585|imex:IM-19491 taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2943893|imex:IM-19491-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dictybase:DDB_G0267690|ensemblprotists:DDB_G0267690(gene)|ensemblprotists:EAL73298(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008104"(protein localization)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032154"(cleavage furrow)|go:"GO:1905345"(protein localization to cleavage furrow)|interpro:IPR005635(Inner centromere protein, ARK binding region)|refseq:XP_647225.1 ensemblprotists:DDB_G0279343(gene)|ensemblprotists:EAL67820(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051233"(spindle midzone)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|reactome:R-DDI-174178|reactome:R-DDI-8854050|refseq:XP_641803.1|dictybase:DDB_G0279343 go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0051326"(telophase)|go:"GO:0051322"(anaphase)|go:"GO:0051323"(metaphase) - - figure legend:Supp. Fig. 3, Supplemental file 9.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") - 2010/11/01 2014/10/16 rogid:EJ8YTiy7pwQIVekeBM1Ie8c0iig44689 rogid:fHmlot1eUhrPn//fCF1TKQiwh5k44689 intact-crc:38C756534CF0DBA0|rigid:iEU0IpA6qKJel0bNNPKs9kH5hG8 false green fluorescent protein tag:?-?|necessary binding region:1014-1320 maltose binding protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q54RN0 uniprotkb:Q54WX4 intact:EBI-2939726 intact:EBI-2939723|ensemblprotists:EAL67820 psi-mi:q54rn0_dicdi(display_long)|uniprotkb:DDB0220646(orf name) psi-mi:aurk_dicdi(display_long)|uniprotkb:aurK(gene name)|psi-mi:aurK(display_short)|uniprotkb:AurB(gene name synonym)|uniprotkb:Aurora(gene name synonym)|uniprotkb:DDB_G0279343(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Li et al. (2008) pubmed:18326585|pubmed:18326585|imex:IM-19491 taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2939722|imex:IM-19491-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0016604"(nuclear body)|go:"GO:0019954"(asexual reproduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051276"(chromosome organization)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|reactome:R-DDI-73772|reactome:R-DDI-983231|refseq:XP_639321.1|dictybase:DDB_G0283023 ensemblprotists:DDB_G0279343(gene)|ensemblprotists:EAL67820(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051233"(spindle midzone)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|reactome:R-DDI-174178|reactome:R-DDI-8854050|refseq:XP_641803.1|dictybase:DDB_G0279343 go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0051326"(telophase)|go:"GO:0051322"(anaphase)|go:"GO:0051323"(metaphase) - - figure legend:Fig. 5A, 5C, 6A, 6B, 6C, 9A.|caution:"Protein [uniprotkb:Q54RN0] has undergone a significant sequence change since thisentry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to unisave."|comment:DdAurora localized normally at the spindle poles and colocalized with HcpA-GFP at the centromeres of Kif12 mutant cells.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") - 2010/11/01 2014/10/16 rogid:2jbt/djDQrXXpr8GvzTE/yQvg2Y44689 rogid:fHmlot1eUhrPn//fCF1TKQiwh5k44689 intact-crc:2A1CCBB78BBFAFED|rigid:CMT18C+TwsDken+TwuiaYXr2kSs false green fluorescent protein tag:?-? - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q54WX4 uniprotkb:Q55GF9 intact:EBI-2939723|ensemblprotists:EAL67820 intact:EBI-922339|ensemblprotists:EAL73298 psi-mi:aurk_dicdi(display_long)|uniprotkb:aurK(gene name)|psi-mi:aurK(display_short)|uniprotkb:AurB(gene name synonym)|uniprotkb:Aurora(gene name synonym)|uniprotkb:DDB_G0279343(orf name) psi-mi:icpa_dicdi(display_long)|uniprotkb:icpA(gene name)|psi-mi:icpA(display_short)|uniprotkb:Incenp(gene name synonym)|uniprotkb:DdINCENP(gene name synonym)|uniprotkb:DDB_G0267690(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Li et al. (2008) pubmed:18326585|pubmed:18326585|imex:IM-19491 taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2939742|imex:IM-19491-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblprotists:DDB_G0279343(gene)|ensemblprotists:EAL67820(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051233"(spindle midzone)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|reactome:R-DDI-174178|reactome:R-DDI-8854050|refseq:XP_641803.1|dictybase:DDB_G0279343 dictybase:DDB_G0267690|ensemblprotists:DDB_G0267690(gene)|ensemblprotists:EAL73298(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008104"(protein localization)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032154"(cleavage furrow)|go:"GO:1905345"(protein localization to cleavage furrow)|interpro:IPR005635(Inner centromere protein, ARK binding region)|refseq:XP_647225.1 go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0051326"(telophase)|go:"GO:0051322"(anaphase)|go:"GO:0051323"(metaphase) - - figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") - 2010/11/01 2014/10/16 rogid:fHmlot1eUhrPn//fCF1TKQiwh5k44689 rogid:EJ8YTiy7pwQIVekeBM1Ie8c0iig44689 intact-crc:A5A614FE35058F5C|rigid:iEU0IpA6qKJel0bNNPKs9kH5hG8 false - green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q55GF9 uniprotkb:Q54WX4 intact:EBI-922339|ensemblprotists:EAL73298 intact:EBI-2939723|ensemblprotists:EAL67820 psi-mi:icpa_dicdi(display_long)|uniprotkb:icpA(gene name)|psi-mi:icpA(display_short)|uniprotkb:Incenp(gene name synonym)|uniprotkb:DdINCENP(gene name synonym)|uniprotkb:DDB_G0267690(orf name) psi-mi:aurk_dicdi(display_long)|uniprotkb:aurK(gene name)|psi-mi:aurK(display_short)|uniprotkb:AurB(gene name synonym)|uniprotkb:Aurora(gene name synonym)|uniprotkb:DDB_G0279343(orf name) psi-mi:"MI:0096"(pull down) Li et al. (2008) pubmed:18326585|pubmed:18326585|imex:IM-19491 taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2943848|imex:IM-19491-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dictybase:DDB_G0267690|ensemblprotists:DDB_G0267690(gene)|ensemblprotists:EAL73298(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008104"(protein localization)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032154"(cleavage furrow)|go:"GO:1905345"(protein localization to cleavage furrow)|interpro:IPR005635(Inner centromere protein, ARK binding region)|refseq:XP_647225.1 ensemblprotists:DDB_G0279343(gene)|ensemblprotists:EAL67820(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051233"(spindle midzone)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|reactome:R-DDI-174178|reactome:R-DDI-8854050|refseq:XP_641803.1|dictybase:DDB_G0279343 go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0051326"(telophase)|go:"GO:0051322"(anaphase)|go:"GO:0051323"(metaphase) - - figure legend:"Supp. Fig. 2A (Supplemental file 8)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") - 2010/11/01 2014/10/16 rogid:EJ8YTiy7pwQIVekeBM1Ie8c0iig44689 rogid:fHmlot1eUhrPn//fCF1TKQiwh5k44689 intact-crc:915CC5148F2C1883|rigid:iEU0IpA6qKJel0bNNPKs9kH5hG8 false - calmodulin binding peptide plus protein a tag:?-?|green fluorescent protein tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q55GF9 uniprotkb:Q54WX4 intact:EBI-922339|ensemblprotists:EAL73298 intact:EBI-2939723|ensemblprotists:EAL67820 psi-mi:icpa_dicdi(display_long)|uniprotkb:icpA(gene name)|psi-mi:icpA(display_short)|uniprotkb:Incenp(gene name synonym)|uniprotkb:DdINCENP(gene name synonym)|uniprotkb:DDB_G0267690(orf name) psi-mi:aurk_dicdi(display_long)|uniprotkb:aurK(gene name)|psi-mi:aurK(display_short)|uniprotkb:AurB(gene name synonym)|uniprotkb:Aurora(gene name synonym)|uniprotkb:DDB_G0279343(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Li et al. (2008) pubmed:18326585|pubmed:18326585|imex:IM-19491 taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2943875|imex:IM-19491-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dictybase:DDB_G0267690|ensemblprotists:DDB_G0267690(gene)|ensemblprotists:EAL73298(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008104"(protein localization)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032154"(cleavage furrow)|go:"GO:1905345"(protein localization to cleavage furrow)|interpro:IPR005635(Inner centromere protein, ARK binding region)|refseq:XP_647225.1 ensemblprotists:DDB_G0279343(gene)|ensemblprotists:EAL67820(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051233"(spindle midzone)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR030616|reactome:R-DDI-174178|reactome:R-DDI-8854050|refseq:XP_641803.1|dictybase:DDB_G0279343 go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0051326"(telophase)|go:"GO:0051322"(anaphase)|go:"GO:0051323"(metaphase) - - figure legend:"Supp. Figs. 2B, 4 (Supplemental file 8 and 10)"|comment:Interaction observed in kif12-/- cells.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)") - 2010/11/01 2014/10/16 rogid:EJ8YTiy7pwQIVekeBM1Ie8c0iig44689 rogid:fHmlot1eUhrPn//fCF1TKQiwh5k44689 intact-crc:83991C7BC2B793AB|rigid:iEU0IpA6qKJel0bNNPKs9kH5hG8 false green fluorescent protein tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)