#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y6E7	uniprotkb:P14735	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2556886|uniprotkb:Q5T5N2|uniprotkb:D3DR35|ensembl:ENSP00000265986|uniprotkb:B2R721|uniprotkb:B7ZAU2	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ide_human(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)|uniprotkb:Abeta-degrading protease(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nidhi et al. (2007)	pubmed:17715127|imex:IM-20430	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606554|imex:IM-20430-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_004960.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0043559"(insulin binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:P14735|rcsb pdb:2G47|rcsb pdb:2G48|rcsb pdb:2G49|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2JBU|rcsb pdb:2JG4|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WK3|rcsb pdb:2YPU|rcsb pdb:3CWW|rcsb pdb:3E4A|rcsb pdb:3E4Z|rcsb pdb:3E50|rcsb pdb:3H44|rcsb pdb:3N56|rcsb pdb:3N57|rcsb pdb:3OFI|rcsb pdb:3QZ2|rcsb pdb:4DTT|rcsb pdb:4DWK|rcsb pdb:4GS8|rcsb pdb:4GSC|rcsb pdb:4GSF|rcsb pdb:4IFH|rcsb pdb:4IOF|rcsb pdb:4LTE|rcsb pdb:4M1C|rcsb pdb:4NXO|rcsb pdb:4PES|rcsb pdb:4PF7|rcsb pdb:4PF9|rcsb pdb:4PFC|rcsb pdb:4QIA|rcsb pdb:4RAL|rcsb pdb:4RE9|rcsb pdb:5CJO|rcsb pdb:3HGZ|rcsb pdb:5UOE|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6B7Y|rcsb pdb:6BF6|rcsb pdb:6BF7|rcsb pdb:6BF8|rcsb pdb:6BF9|rcsb pdb:6BFC|rcsb pdb:6BYZ|rcsb pdb:6EDS|rcsb pdb:6MQ3|reactome:R-HSA-5689880|reactome:R-HSA-9033241|rcsb pdb:6B7Z|refseq:NP_001159418.1|dip:DIP-55771N	-	-	-	figure legend:Supplemental Materials|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:dwngN3kUOExC5qapSgF01YhBNAM9606	intact-crc:B82386295242960F|rigid:xsUm3+cweB7rzgz5rL5yMWo4KcI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Y6E7	uniprotkb:P12236	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-356254|ensembl:ENSP00000370808|uniprotkb:Q96C49	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:adt3_human(display_long)|uniprotkb:SLC25A6(gene name)|psi-mi:SLC25A6(display_short)|uniprotkb:ANT3(gene name synonym)|uniprotkb:CDABP0051(orf name)|uniprotkb:Adenine nucleotide translocator 3(gene name synonym)|uniprotkb:ADP,ATP carrier protein 3(gene name synonym)|uniprotkb:Solute carrier family 25 member 6(gene name synonym)|uniprotkb:ADP,ATP carrier protein, isoform T2(gene name synonym)|uniprotkb:AAC3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nidhi et al. (2007)	pubmed:17715127|imex:IM-20430	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606554|imex:IM-20430-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	ensembl:ENSG00000169100(gene)|ensembl:ENST00000381401(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P12236|reactome:R-HSA-1268020|reactome:R-HSA-168277|reactome:R-HSA-180897|reactome:R-HSA-83936|refseq:NP_001627.2	-	-	-	figure legend:Supplemental Materials|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:K5zi7otVqbL4Z4NHyHB1nojLOTg9606	intact-crc:B82386295242960F|rigid:xsUm3+cweB7rzgz5rL5yMWo4KcI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Y6E7	uniprotkb:P05141	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nidhi et al. (2007)	pubmed:17715127|imex:IM-20430	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606554|imex:IM-20430-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N	-	-	-	figure legend:Supplemental Materials|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606	intact-crc:B82386295242960F|rigid:xsUm3+cweB7rzgz5rL5yMWo4KcI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Y6E7	uniprotkb:Q9NTG7	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-724621|uniprotkb:Q9Y6E8|ensembl:ENSP00000372191|uniprotkb:B7Z5U6	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:sir3_human(display_long)|uniprotkb:SIRT3(gene name)|psi-mi:SIRT3(display_short)|uniprotkb:SIR2L3(gene name synonym)|uniprotkb:SIR2-like protein 3(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nidhi et al. (2007)	pubmed:17715127|imex:IM-20430	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606570|imex:IM-20430-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_001017524.1|refseq:NP_036371.1|ensembl:ENSG00000142082(gene)|ensembl:ENST00000382743(transcript)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009060"(aerobic respiration)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070403"(NAD+ binding)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902553"(positive regulation of catalase activity)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|go:"GO:0043565"(sequence-specific DNA binding)|rcsb pdb:3GLR|rcsb pdb:3GLS|rcsb pdb:3GLT|rcsb pdb:3GLU|rcsb pdb:4BN4|rcsb pdb:4BN5|rcsb pdb:4BV3|rcsb pdb:4BVB|rcsb pdb:4BVF|rcsb pdb:4BVG|rcsb pdb:4BVH|rcsb pdb:4C78|rcsb pdb:4C7B|rcsb pdb:4FVT|rcsb pdb:4FZ3|rcsb pdb:4HD8|rcsb pdb:4JSR|rcsb pdb:4JT8|rcsb pdb:4JT9|rcsb pdb:4O8Z|rcsb pdb:5BWN|rcsb pdb:5BWO|rcsb pdb:5D7N|rcsb pdb:5H4D|rcsb pdb:5Y4H|rcsb pdb:5YTK|rcsb pdb:5Z93|rcsb pdb:5Z94|rcsb pdb:5ZGC|rcsb pdb:6ISO|reactome:R-HSA-2151201|reactome:R-HSA-9615017|reactome:R-HSA-9617629|rcsb pdb:4BVE|refseq:XP_016872919.1|dip:DIP-46861N	-	-	-	figure legend:Fig 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:KGNwfCABi61filBQeIU5v5n51kE9606	intact-crc:D9A37A80DCB3EAB7|rigid:UsEevybCT/s6w9p8VJkrcN8leq8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6E7	uniprotkb:P14735	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	intact:EBI-2556886|uniprotkb:Q5T5N2|uniprotkb:D3DR35|ensembl:ENSP00000265986|uniprotkb:B2R721|uniprotkb:B7ZAU2	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:ide_human(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)|uniprotkb:Abeta-degrading protease(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nidhi et al. (2007)	pubmed:17715127|imex:IM-20430	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606570|imex:IM-20430-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	refseq:NP_004960.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0043559"(insulin binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:P14735|rcsb pdb:2G47|rcsb pdb:2G48|rcsb pdb:2G49|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2JBU|rcsb pdb:2JG4|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WK3|rcsb pdb:2YPU|rcsb pdb:3CWW|rcsb pdb:3E4A|rcsb pdb:3E4Z|rcsb pdb:3E50|rcsb pdb:3H44|rcsb pdb:3N56|rcsb pdb:3N57|rcsb pdb:3OFI|rcsb pdb:3QZ2|rcsb pdb:4DTT|rcsb pdb:4DWK|rcsb pdb:4GS8|rcsb pdb:4GSC|rcsb pdb:4GSF|rcsb pdb:4IFH|rcsb pdb:4IOF|rcsb pdb:4LTE|rcsb pdb:4M1C|rcsb pdb:4NXO|rcsb pdb:4PES|rcsb pdb:4PF7|rcsb pdb:4PF9|rcsb pdb:4PFC|rcsb pdb:4QIA|rcsb pdb:4RAL|rcsb pdb:4RE9|rcsb pdb:5CJO|rcsb pdb:3HGZ|rcsb pdb:5UOE|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6B7Y|rcsb pdb:6BF6|rcsb pdb:6BF7|rcsb pdb:6BF8|rcsb pdb:6BF9|rcsb pdb:6BFC|rcsb pdb:6BYZ|rcsb pdb:6EDS|rcsb pdb:6MQ3|reactome:R-HSA-5689880|reactome:R-HSA-9033241|rcsb pdb:6B7Z|refseq:NP_001159418.1|dip:DIP-55771N	-	-	-	figure legend:Fig 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	rogid:dwngN3kUOExC5qapSgF01YhBNAM9606	intact-crc:D9A37A80DCB3EAB7|rigid:UsEevybCT/s6w9p8VJkrcN8leq8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05141	uniprotkb:Q9Y6E7	intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671	intact:EBI-2606540|uniprotkb:Q32M33|uniprotkb:O43346|ensembl:ENSP00000202967	psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym)	psi-mi:sir4_human(display_long)|uniprotkb:SIR2L4(gene name synonym)|uniprotkb:SIR2-like protein 4(gene name synonym)|uniprotkb:SIRT4(gene name)|psi-mi:SIRT4(display_short)|uniprotkb:NAD-dependent protein deacetylase sirtuin-4(gene name synonym)|uniprotkb:NAD-dependent ADP-ribosyltransferase sirtuin-4(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nidhi et al. (2007)	pubmed:17715127|imex:IM-20430	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606582|imex:IM-20430-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N	refseq:NP_036372.1|ensembl:ENSG00000089163(gene)|ensembl:ENST00000202967(transcript)|go:"GO:0000820"(regulation of glutamine family amino acid metabolic process)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072350"(tricarboxylic acid metabolic process)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1904182"(regulation of pyruvate dehydrogenase activity)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026587|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|reactome:R-HSA-2151201|go:"GO:0047708"(biotinidase activity)|go:"GO:0061690"(lipoamidase activity)|refseq:XP_006719371.1|refseq:XP_006719372.1	-	-	-	figure legend:Fig 5B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606	rogid:TFgum1la5pGhfQmAaLYSRCw0JH49606	intact-crc:D7D6262F714662BC|rigid:fap0jJtE0TfdvUMN21MiMy6/5sc	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)