#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P19941 uniprotkb:O35717 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617349|ensembl:ENSMUSP00000020215|ensembl:ENSMUSP00000113378|ensembl:ENSMUSP00000129331|ensembl:ENSMUSP00000131875 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:socs2_mouse(display_long)|uniprotkb:Cytokine-inducible SH2 protein 2(gene name synonym)|uniprotkb:Socs2(gene name)|psi-mi:Socs2(display_short)|uniprotkb:Cis2(gene name synonym)|uniprotkb:Cish2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7526276|mint:MINT-8028479 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8028483(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000020027(gene)|ensembl:ENSMUST00000020215(transcript)|ensembl:ENSMUST00000119917(transcript)|ensembl:ENSMUST00000170690(transcript)|ensembl:ENSMUST00000172070(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007595"(lactation)|go:"GO:0008269"(JAK pathway signal transduction adaptor activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060749"(mammary gland alveolus development)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028410|interpro:IPR035862|interpro:IPR036036|interpro:IPR036860|mint:O35717|reactome:R-MMU-8951664|reactome:R-MMU-9706369|refseq:XP_011241712.1|refseq:NP_001162126.1|refseq:NP_001162127.1|refseq:NP_001162128.1|refseq:NP_031732.1|mint:MINT-8028480(identity)|uniprotkb:O35717(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:m33nS0ixYDkwyJVqB7/Tmlum//g10090 intact-crc:A6C223B17C7E8337|rigid:tfl3qNdkcGcr2eiT4/wXoMgGpvk false phosphorylated residue:595-595(MINT-8028488)|binding-associated region:588-601(MINT-8028486) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:P42230 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617434|ensembl:ENSMUSP00000004145|ensembl:ENSMUSP00000102979 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:sta5a_mouse(display_long)|uniprotkb:Mammary gland factor(gene name synonym)|uniprotkb:Stat5a(gene name)|psi-mi:Stat5a(display_short)|uniprotkb:Mgf(gene name synonym)|uniprotkb:Mpf(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7526352|mint:MINT-8029190 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8029194(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000004043(gene)|ensembl:ENSMUST00000004145(transcript)|ensembl:ENSMUST00000107356(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060376"(positive regulation of mast cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046543"(development of secondary female sexual characteristics)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42230|rcsb pdb:1Y1U|reactome:R-MMU-1251985|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_035618.1|refseq:XP_006532784.1|refseq:XP_006532785.1|refseq:XP_017169891.1|dip:DIP-897N|mint:MINT-8029191(identity)|uniprotkb:P42230(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:Z/+QC7Q0bZ6GIEUJJbNEIyeu+xU10090 intact-crc:AADE8373428BD0E1|rigid:cc1bos+NQcKm8PvuwVAIFrPAwCg false binding-associated region:527-540(MINT-8029197)|phosphorylated residue:534-534(MINT-8029199) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:Q62225 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617489|ensembl:ENSMUSP00000082183|uniprotkb:Q3TC70 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:cish_mouse(display_long)|uniprotkb:CIS-1(gene name synonym)|uniprotkb:Suppressor of cytokine signaling(gene name synonym)|uniprotkb:Cish(gene name)|psi-mi:Cish(display_short)|uniprotkb:Cis(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7526335|mint:MINT-8028490 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8028494(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000032578(gene)|ensembl:ENSMUST00000085102(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028425|interpro:IPR035887|interpro:IPR036036|interpro:IPR036860|mint:Q62225|reactome:R-MMU-8951664|refseq:NP_034025.1|refseq:NP_001304283.1|dip:DIP-907N|mint:MINT-8028491(identity)|uniprotkb:Q62225(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:6VsFfr+LOZZOI8gwptkglukw3Mo10090 intact-crc:51DBC662FBC45E1F|rigid:7xx7lXeJYnoHzhMKjoOmtAKbCbk false phosphorylated residue:595-595(MINT-8028499)|binding-associated region:588-601(MINT-8028497) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:P42232 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617454|ensembl:ENSMUSP00000004143|ensembl:ENSMUSP00000102981|uniprotkb:Q541Q5|uniprotkb:Q60804|uniprotkb:Q8K3Q1|uniprotkb:Q9JKM1|uniprotkb:Q9R0X8|uniprotkb:A2A5D5 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:sta5b_mouse(display_long)|uniprotkb:Stat5b(gene name)|psi-mi:Stat5b(display_short) psi-mi:"MI:0018"(two hybrid) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7526385|mint:MINT-8029201 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8029205(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000020919(gene)|ensembl:ENSMUST00000004143(transcript)|ensembl:ENSMUST00000107358(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007548"(sex differentiation)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_001107035.1|refseq:NP_035619.3|refseq:XP_017169892.1|dip:DIP-898N|mint:MINT-8029202(identity)|uniprotkb:P42232(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:BEl9ugwAhh8tuSA/6WCoHXlzy3c10090 intact-crc:0CF7E13E32278F28|rigid:PrtV8CTYQrS2L4+70JXPUA8vPoQ false phosphorylated residue:534-534(MINT-8029210)|binding-associated region:527-540(MINT-8029208) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:P42232 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617454|ensembl:ENSMUSP00000004143|ensembl:ENSMUSP00000102981|uniprotkb:Q541Q5|uniprotkb:Q60804|uniprotkb:Q8K3Q1|uniprotkb:Q9JKM1|uniprotkb:Q9R0X8|uniprotkb:A2A5D5 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:sta5b_mouse(display_long)|uniprotkb:Stat5b(gene name)|psi-mi:Stat5b(display_short) psi-mi:"MI:0018"(two hybrid) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7526500|mint:MINT-8029529 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8029533(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000020919(gene)|ensembl:ENSMUST00000004143(transcript)|ensembl:ENSMUST00000107358(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007548"(sex differentiation)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_001107035.1|refseq:NP_035619.3|refseq:XP_017169892.1|dip:DIP-898N|mint:MINT-8029530(identity)|uniprotkb:P42232(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:BEl9ugwAhh8tuSA/6WCoHXlzy3c10090 intact-crc:A06DBE55E535F2A7|rigid:PrtV8CTYQrS2L4+70JXPUA8vPoQ false binding-associated region:620-633(MINT-8029536)|phosphorylated residue:627-627(MINT-8029538) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:P42230 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617434|ensembl:ENSMUSP00000004145|ensembl:ENSMUSP00000102979 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:sta5a_mouse(display_long)|uniprotkb:Mammary gland factor(gene name synonym)|uniprotkb:Stat5a(gene name)|psi-mi:Stat5a(display_short)|uniprotkb:Mgf(gene name synonym)|uniprotkb:Mpf(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7526467|mint:MINT-8029518 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8029522(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000004043(gene)|ensembl:ENSMUST00000004145(transcript)|ensembl:ENSMUST00000107356(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060376"(positive regulation of mast cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046543"(development of secondary female sexual characteristics)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42230|rcsb pdb:1Y1U|reactome:R-MMU-1251985|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_035618.1|refseq:XP_006532784.1|refseq:XP_006532785.1|refseq:XP_017169891.1|dip:DIP-897N|mint:MINT-8029519(identity)|uniprotkb:P42230(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:Z/+QC7Q0bZ6GIEUJJbNEIyeu+xU10090 intact-crc:0644DC189599AD6E|rigid:cc1bos+NQcKm8PvuwVAIFrPAwCg false binding-associated region:620-633(MINT-8029525)|phosphorylated residue:627-627(MINT-8029527) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:P42232 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617454|ensembl:ENSMUSP00000004143|ensembl:ENSMUSP00000102981|uniprotkb:Q541Q5|uniprotkb:Q60804|uniprotkb:Q8K3Q1|uniprotkb:Q9JKM1|uniprotkb:Q9R0X8|uniprotkb:A2A5D5 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:sta5b_mouse(display_long)|uniprotkb:Stat5b(gene name)|psi-mi:Stat5b(display_short) psi-mi:"MI:0018"(two hybrid) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7526567|mint:MINT-8033190 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8033194(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000020919(gene)|ensembl:ENSMUST00000004143(transcript)|ensembl:ENSMUST00000107358(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007548"(sex differentiation)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_001107035.1|refseq:NP_035619.3|refseq:XP_017169892.1|dip:DIP-898N|mint:MINT-8033191(identity)|uniprotkb:P42232(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:BEl9ugwAhh8tuSA/6WCoHXlzy3c10090 intact-crc:B924EFEDE0965830|rigid:PrtV8CTYQrS2L4+70JXPUA8vPoQ false binding-associated region:559-572(MINT-8033197)|phosphorylated residue:566-566(MINT-8033199) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:P42230 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617434|ensembl:ENSMUSP00000004145|ensembl:ENSMUSP00000102979 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:sta5a_mouse(display_long)|uniprotkb:Mammary gland factor(gene name synonym)|uniprotkb:Stat5a(gene name)|psi-mi:Stat5a(display_short)|uniprotkb:Mgf(gene name synonym)|uniprotkb:Mpf(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7526550|mint:MINT-8033179 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8033183(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000004043(gene)|ensembl:ENSMUST00000004145(transcript)|ensembl:ENSMUST00000107356(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060376"(positive regulation of mast cell differentiation)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046543"(development of secondary female sexual characteristics)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR036535|interpro:IPR036860|mint:P42230|rcsb pdb:1Y1U|reactome:R-MMU-1251985|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_035618.1|refseq:XP_006532784.1|refseq:XP_006532785.1|refseq:XP_017169891.1|dip:DIP-897N|mint:MINT-8033180(identity)|uniprotkb:P42230(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:Z/+QC7Q0bZ6GIEUJJbNEIyeu+xU10090 intact-crc:1F0D8DA0903A07F9|rigid:cc1bos+NQcKm8PvuwVAIFrPAwCg false binding-associated region:559-572(MINT-8033186)|phosphorylated residue:566-566(MINT-8033188) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:O35717 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617349|ensembl:ENSMUSP00000020215|ensembl:ENSMUSP00000113378|ensembl:ENSMUSP00000129331|ensembl:ENSMUSP00000131875 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:socs2_mouse(display_long)|uniprotkb:Cytokine-inducible SH2 protein 2(gene name synonym)|uniprotkb:Socs2(gene name)|psi-mi:Socs2(display_short)|uniprotkb:Cis2(gene name synonym)|uniprotkb:Cish2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7526617|mint:MINT-8033672 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8033676(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000020027(gene)|ensembl:ENSMUST00000020215(transcript)|ensembl:ENSMUST00000119917(transcript)|ensembl:ENSMUST00000170690(transcript)|ensembl:ENSMUST00000172070(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007595"(lactation)|go:"GO:0008269"(JAK pathway signal transduction adaptor activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060749"(mammary gland alveolus development)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028410|interpro:IPR035862|interpro:IPR036036|interpro:IPR036860|mint:O35717|reactome:R-MMU-8951664|reactome:R-MMU-9706369|refseq:XP_011241712.1|refseq:NP_001162126.1|refseq:NP_001162127.1|refseq:NP_001162128.1|refseq:NP_031732.1|mint:MINT-8033673(identity)|uniprotkb:O35717(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:m33nS0ixYDkwyJVqB7/Tmlum//g10090 intact-crc:8532297B60330ABA|rigid:tfl3qNdkcGcr2eiT4/wXoMgGpvk false phosphorylated residue:487-487(MINT-8033681)|binding-associated region:480-493(MINT-8033679) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:P42232 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617454|ensembl:ENSMUSP00000004143|ensembl:ENSMUSP00000102981|uniprotkb:Q541Q5|uniprotkb:Q60804|uniprotkb:Q8K3Q1|uniprotkb:Q9JKM1|uniprotkb:Q9R0X8|uniprotkb:A2A5D5 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:sta5b_mouse(display_long)|uniprotkb:Stat5b(gene name)|psi-mi:Stat5b(display_short) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7526430|mint:MINT-8029216 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8029220(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000020919(gene)|ensembl:ENSMUST00000004143(transcript)|ensembl:ENSMUST00000107358(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007548"(sex differentiation)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_001107035.1|refseq:NP_035619.3|refseq:XP_017169892.1|dip:DIP-898N|mint:MINT-8029217(identity)|uniprotkb:P42232(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:BEl9ugwAhh8tuSA/6WCoHXlzy3c10090 intact-crc:C68582C4B13AB4F4|rigid:PrtV8CTYQrS2L4+70JXPUA8vPoQ false phosphorylated residue:534-534(MINT-8029225)|binding-associated region:527-540(MINT-8029223) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:P42232 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617454|ensembl:ENSMUSP00000004143|ensembl:ENSMUSP00000102981|uniprotkb:Q541Q5|uniprotkb:Q60804|uniprotkb:Q8K3Q1|uniprotkb:Q9JKM1|uniprotkb:Q9R0X8|uniprotkb:A2A5D5 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:sta5b_mouse(display_long)|uniprotkb:Stat5b(gene name)|psi-mi:Stat5b(display_short) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7526517|mint:MINT-8029544 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8029548(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000020919(gene)|ensembl:ENSMUST00000004143(transcript)|ensembl:ENSMUST00000107358(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007548"(sex differentiation)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_001107035.1|refseq:NP_035619.3|refseq:XP_017169892.1|dip:DIP-898N|mint:MINT-8029545(identity)|uniprotkb:P42232(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:BEl9ugwAhh8tuSA/6WCoHXlzy3c10090 intact-crc:100CD1D222DC6B4F|rigid:PrtV8CTYQrS2L4+70JXPUA8vPoQ false binding-associated region:620-633(MINT-8029551)|phosphorylated residue:627-627(MINT-8029553) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:P42232 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617454|ensembl:ENSMUSP00000004143|ensembl:ENSMUSP00000102981|uniprotkb:Q541Q5|uniprotkb:Q60804|uniprotkb:Q8K3Q1|uniprotkb:Q9JKM1|uniprotkb:Q9R0X8|uniprotkb:A2A5D5 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:sta5b_mouse(display_long)|uniprotkb:Stat5b(gene name)|psi-mi:Stat5b(display_short) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7526584|mint:MINT-8033205 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8033209(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000020919(gene)|ensembl:ENSMUST00000004143(transcript)|ensembl:ENSMUST00000107358(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007548"(sex differentiation)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-512988|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-982772|refseq:NP_001107035.1|refseq:NP_035619.3|refseq:XP_017169892.1|dip:DIP-898N|mint:MINT-8033206(identity)|uniprotkb:P42232(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:BEl9ugwAhh8tuSA/6WCoHXlzy3c10090 intact-crc:9093B2B60CA5777E|rigid:PrtV8CTYQrS2L4+70JXPUA8vPoQ false phosphorylated residue:566-566(MINT-8033214)|binding-associated region:559-572(MINT-8033212) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19941 uniprotkb:Q62225 intact:EBI-7526279|intact:MINT-1535520 intact:EBI-617489|ensembl:ENSMUSP00000082183|uniprotkb:Q3TC70 psi-mi:ghr_rabit(display_long)|uniprotkb:GHR(gene name)|psi-mi:GHR(display_short)|uniprotkb:Somatotropin receptor(gene name synonym) psi-mi:cish_mouse(display_long)|uniprotkb:CIS-1(gene name synonym)|uniprotkb:Suppressor of cytokine signaling(gene name synonym)|uniprotkb:Cish(gene name)|psi-mi:Cish(display_short)|uniprotkb:Cis(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Uyttendaele et al. (2007) pubmed:17666591|mint:MINT-6731810 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7526646|mint:MINT-8033687 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076105.1|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070064"(proline-rich region binding)|interpro:IPR003528(Long hematopoietin receptor, single chain, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR025871|interpro:IPR036116|go:"GO:0031904"(endosome lumen)|dip:DIP-313N|mint:MINT-8033691(identity)|uniprotkb:P19941(original identifier) ensembl:ENSMUSG00000032578(gene)|ensembl:ENSMUST00000085102(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028425|interpro:IPR035887|interpro:IPR036036|interpro:IPR036860|mint:Q62225|reactome:R-MMU-8951664|refseq:NP_034025.1|refseq:NP_001304283.1|dip:DIP-907N|mint:MINT-8033688(identity)|uniprotkb:Q62225(original identifier) - function:Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway|comment:mint|function:"The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling" - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:NUZbnICzd8tYqRiIPZqyL9ysyc89986 rogid:6VsFfr+LOZZOI8gwptkglukw3Mo10090 intact-crc:1C01FCF2E7F9F2C5|rigid:7xx7lXeJYnoHzhMKjoOmtAKbCbk false binding-associated region:480-493(MINT-8033694)|phosphorylated residue:487-487(MINT-8033696) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)