#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30543	uniprotkb:P20272	intact:EBI-2902822|ensembl:ENSRNOP00000001759	intact:EBI-2909800|ensembl:ENSRNOP00000010850	psi-mi:aa2ar_rat(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:cnr1_rat(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Skr6(gene name synonym)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Carriba et al. (2007)	pubmed:17356572|imex:IM-19499	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1262"(I2D)	intact:EBI-2909847|imex:IM-19499-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0919"(acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000001302(gene)|ensembl:ENSRNOT00000001759(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-5683826|go:"GO:0043116"(negative regulation of vascular permeability)|rgd:2049|refseq:NP_445746.3|refseq:XP_017457041.1|refseq:XP_017457042.1|refseq:XP_017457043.1|refseq:XP_017457044.1	go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSRNOG00000008223(gene)|ensembl:ENSRNOT00000010850(transcript)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P20272|reactome:R-RNO-373076|reactome:R-RNO-418594|rgd:2369|refseq:NP_036916.1|refseq:XP_017448640.1|refseq:XP_006238046.1	-	-	-	figure legend:Fig.2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-striatum)|taxid:10116(Rattus norvegicus brian stiatum)	-	2010/08/23	2014/10/16	rogid:sXgn+A8OWk43DSsggsiGWPmC8gk10116	rogid:20v4cQlJANWwtgoDM8MyFQNnRZY10116	intact-crc:C4C6A08329075D87|rigid:1QDdkC1rQEuKe3qmxWsP6hlJ9SM	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P30543	uniprotkb:P20272	intact:EBI-2902822|ensembl:ENSRNOP00000001759	intact:EBI-2909800|ensembl:ENSRNOP00000010850	psi-mi:aa2ar_rat(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:cnr1_rat(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Skr6(gene name synonym)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Carriba et al. (2007)	pubmed:17356572|imex:IM-19499	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2909851|imex:IM-19499-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000001302(gene)|ensembl:ENSRNOT00000001759(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-5683826|go:"GO:0043116"(negative regulation of vascular permeability)|rgd:2049|refseq:NP_445746.3|refseq:XP_017457041.1|refseq:XP_017457042.1|refseq:XP_017457043.1|refseq:XP_017457044.1	go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSRNOG00000008223(gene)|ensembl:ENSRNOT00000010850(transcript)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P20272|reactome:R-RNO-373076|reactome:R-RNO-418594|rgd:2369|refseq:NP_036916.1|refseq:XP_017448640.1|refseq:XP_006238046.1	-	-	-	figure legend:Fig.3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-striatum)|taxid:10116(Rattus norvegicus brian stiatum)	-	2010/08/23	2014/10/16	rogid:sXgn+A8OWk43DSsggsiGWPmC8gk10116	rogid:20v4cQlJANWwtgoDM8MyFQNnRZY10116	intact-crc:FE0BA15C2A56B3CF|rigid:1QDdkC1rQEuKe3qmxWsP6hlJ9SM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30543	uniprotkb:P20272	intact:EBI-2902822|ensembl:ENSRNOP00000001759	intact:EBI-2909800|ensembl:ENSRNOP00000010850	psi-mi:aa2ar_rat(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:cnr1_rat(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Skr6(gene name synonym)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Carriba et al. (2007)	pubmed:17356572|imex:IM-19499	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2909855|imex:IM-19499-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000001302(gene)|ensembl:ENSRNOT00000001759(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-5683826|go:"GO:0043116"(negative regulation of vascular permeability)|rgd:2049|refseq:NP_445746.3|refseq:XP_017457041.1|refseq:XP_017457042.1|refseq:XP_017457043.1|refseq:XP_017457044.1	go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSRNOG00000008223(gene)|ensembl:ENSRNOT00000010850(transcript)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P20272|reactome:R-RNO-373076|reactome:R-RNO-418594|rgd:2369|refseq:NP_036916.1|refseq:XP_017448640.1|refseq:XP_006238046.1	-	-	-	figure legend:Fig.3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-striatum)|taxid:10116(Rattus norvegicus brian stiatum)	-	2010/08/23	2014/10/16	rogid:sXgn+A8OWk43DSsggsiGWPmC8gk10116	rogid:20v4cQlJANWwtgoDM8MyFQNnRZY10116	intact-crc:13B9A5B1953FE62F|rigid:1QDdkC1rQEuKe3qmxWsP6hlJ9SM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29274	uniprotkb:P21554	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Carriba et al. (2007)	pubmed:17356572|imex:IM-19499	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1262"(I2D)	intact:EBI-2909909|imex:IM-19499-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Fig. 4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/08/23	2014/10/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	intact-crc:3F26AB1314FD55D8|rigid:OJDdRAer5iPxx+PHUud52D0kvAM	false	renilla luciferase protein tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P29274	uniprotkb:P21554	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Carriba et al. (2007)	pubmed:17356572|imex:IM-19499	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1262"(I2D)	intact:EBI-2909917|imex:IM-19499-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Fig. 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/08/23	2014/10/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	intact-crc:5A406229FF2BE2DE|rigid:OJDdRAer5iPxx+PHUud52D0kvAM	false	renilla luciferase protein tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P29274	uniprotkb:P21554	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Carriba et al. (2007)	pubmed:17356572|imex:IM-19499	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1262"(I2D)	intact:EBI-2909932|imex:IM-19499-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Fig. 5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2010/08/23	2014/10/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	intact-crc:841914718DDB862D|rigid:OJDdRAer5iPxx+PHUud52D0kvAM	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)