#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07998	uniprotkb:P13489	intact:EBI-2823523|uniprotkb:D3DS06|uniprotkb:Q6ICS5|uniprotkb:Q9UCB5|uniprotkb:Q1KHR2|uniprotkb:B2R589|uniprotkb:Q9UCB4|uniprotkb:Q16869|uniprotkb:Q16830|ensembl:ENSP00000344193|ensembl:ENSP00000381057|ensembl:ENSP00000381060|ensembl:ENSP00000399493	intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734	psi-mi:rnas1_human(display_long)|uniprotkb:RNASE1(gene name)|psi-mi:RNASE1(display_short)|uniprotkb:RIB1(gene name synonym)|uniprotkb:RNS1(gene name synonym)|uniprotkb:HP-RNase(gene name synonym)|uniprotkb:RIB-1(gene name synonym)|uniprotkb:RNase UpI-1(gene name synonym)|uniprotkb:Ribonuclease 1(gene name synonym)|uniprotkb:Ribonuclease A(gene name synonym)	psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	- (2007)	pubmed:17350650|imex:IM-16944	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944883|wwpdb:1Z7X|imex:IM-16944-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002924.1|refseq:NP_937875.1|refseq:NP_937877.1|refseq:NP_937878.1|ensembl:ENSG00000129538(gene)|ensembl:ENST00000340900(transcript)|ensembl:ENST00000397967(transcript)|ensembl:ENST00000397970(transcript)|ensembl:ENST00000412779(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004522"(ribonuclease A activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0016829"(lyase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|mint:P07998|rcsb pdb:1DZA|rcsb pdb:1E21|rcsb pdb:1H8X|rcsb pdb:1Z7X|rcsb pdb:2E0J|rcsb pdb:2E0L|rcsb pdb:2E0M|rcsb pdb:2E0O|rcsb pdb:2K11|rcsb pdb:2Q4G|rcsb pdb:3F8G|rcsb pdb:4KXH|reactome:R-HSA-9613829|reactome:R-HSA-9615710	refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript)	-	-	-	3d-resolution:1.95A|3d-r-factors:"R-working:17.5% R-free:23.6%"|figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/16	2014/10/16	rogid:pOyV+GmwHrK9ALqklzbSFYxTmu09606	rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606	intact-crc:00FB9E2CE4B174DC|rigid:+LT9yfTDM8grHEZqyJ3+0Z+9dHU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13489	uniprotkb:P07998	intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734	intact:EBI-2823523|uniprotkb:D3DS06|uniprotkb:Q6ICS5|uniprotkb:Q9UCB5|uniprotkb:Q1KHR2|uniprotkb:B2R589|uniprotkb:Q9UCB4|uniprotkb:Q16869|uniprotkb:Q16830|ensembl:ENSP00000344193|ensembl:ENSP00000381057|ensembl:ENSP00000381060|ensembl:ENSP00000399493	psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym)	psi-mi:rnas1_human(display_long)|uniprotkb:RNASE1(gene name)|psi-mi:RNASE1(display_short)|uniprotkb:RIB1(gene name synonym)|uniprotkb:RNS1(gene name synonym)|uniprotkb:HP-RNase(gene name synonym)|uniprotkb:RIB-1(gene name synonym)|uniprotkb:RNase UpI-1(gene name synonym)|uniprotkb:Ribonuclease 1(gene name synonym)|uniprotkb:Ribonuclease A(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	- (2007)	pubmed:17350650|imex:IM-16944	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946600|wwpdb:1Z7X|imex:IM-16944-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript)	refseq:NP_002924.1|refseq:NP_937875.1|refseq:NP_937877.1|refseq:NP_937878.1|ensembl:ENSG00000129538(gene)|ensembl:ENST00000340900(transcript)|ensembl:ENST00000397967(transcript)|ensembl:ENST00000397970(transcript)|ensembl:ENST00000412779(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004522"(ribonuclease A activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0016829"(lyase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|mint:P07998|rcsb pdb:1DZA|rcsb pdb:1E21|rcsb pdb:1H8X|rcsb pdb:1Z7X|rcsb pdb:2E0J|rcsb pdb:2E0L|rcsb pdb:2E0M|rcsb pdb:2E0O|rcsb pdb:2K11|rcsb pdb:2Q4G|rcsb pdb:3F8G|rcsb pdb:4KXH|reactome:R-HSA-9613829|reactome:R-HSA-9615710	-	-	-	figure legend:Table 3|kinetics:Kcat/KM = 21E106 M-1sec-1|kinetic_conditions:pH6.0, 25C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/16	2014/10/16	rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606	rogid:pOyV+GmwHrK9ALqklzbSFYxTmu09606	intact-crc:E9F43164CAFDC25F|rigid:+LT9yfTDM8grHEZqyJ3+0Z+9dHU	false	-	mutation decreasing interaction:116-116,66-67,95-95|mutation decreasing interaction:67-67,95-95,116-117,119-119|mutation decreasing interaction:119-119,117-117,95-95,67-67|mutation decreasing interaction:67-67,116-117,95-95|fluorescein label:?-?|mutation decreasing interaction:67-67,116-117,95-95,119-119	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-2944965	uniprotkb:P07998	-	intact:EBI-2823523|uniprotkb:D3DS06|uniprotkb:Q6ICS5|uniprotkb:Q9UCB5|uniprotkb:Q1KHR2|uniprotkb:B2R589|uniprotkb:Q9UCB4|uniprotkb:Q16869|uniprotkb:Q16830|ensembl:ENSP00000344193|ensembl:ENSP00000381057|ensembl:ENSP00000381060|ensembl:ENSP00000399493	psi-mi:fam_nucleotide_tamra(display_short)|psi-mi:EBI-2944965(display_long)	psi-mi:rnas1_human(display_long)|uniprotkb:RNASE1(gene name)|psi-mi:RNASE1(display_short)|uniprotkb:RIB1(gene name synonym)|uniprotkb:RNS1(gene name synonym)|uniprotkb:HP-RNase(gene name synonym)|uniprotkb:RIB-1(gene name synonym)|uniprotkb:RNase UpI-1(gene name synonym)|uniprotkb:Ribonuclease 1(gene name synonym)|uniprotkb:Ribonuclease A(gene name synonym)	psi-mi:"MI:0920"(ribonuclease assay)	- (2007)	pubmed:17350650|imex:IM-16944	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0902"(rna cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2945786|imex:IM-16944-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0320"(ribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002924.1|refseq:NP_937875.1|refseq:NP_937877.1|refseq:NP_937878.1|ensembl:ENSG00000129538(gene)|ensembl:ENST00000340900(transcript)|ensembl:ENST00000397967(transcript)|ensembl:ENST00000397970(transcript)|ensembl:ENST00000412779(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004522"(ribonuclease A activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0016829"(lyase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|mint:P07998|rcsb pdb:1DZA|rcsb pdb:1E21|rcsb pdb:1H8X|rcsb pdb:1Z7X|rcsb pdb:2E0J|rcsb pdb:2E0L|rcsb pdb:2E0M|rcsb pdb:2E0O|rcsb pdb:2K11|rcsb pdb:2Q4G|rcsb pdb:3F8G|rcsb pdb:4KXH|reactome:R-HSA-9613829|reactome:R-HSA-9615710	-	comment:"a tetranucleotide with a 5',6-carboxyfluorescein label (6-FAM) and a 3',6-carboxy-tetramethylrhodamine (6-TAMRA) label:"	-	figure legend:Table 3|kinetics:Kcat/KM = 21E106 M-1sec-1|kinetic_conditions:pH6.0, 25C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/16	2014/10/16	-	rogid:pOyV+GmwHrK9ALqklzbSFYxTmu09606	intact-crc:0302B14A9C197910	false	-	mutation decreasing interaction:116-116,66-67,95-95|mutation decreasing interaction:116-117,67-67,119-119,95-95|mutation decreasing interaction:119-119,117-117,95-95,67-67|mutation decreasing interaction:116-117,67-67,95-95|mutation increasing interaction:116-117,67-67,119-119,95-95	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)