#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06199	uniprotkb:P29067	intact:EBI-2898810|ensembl:ENSSSCP00005018264|ensembl:ENSSSCP00005018285|ensembl:ENSSSCP00015019670|ensembl:ENSSSCP00015019722|ensembl:ENSSSCP00025004979|ensembl:ENSSSCP00030042034|ensembl:ENSSSCP00035005909|ensembl:ENSSSCP00045027745|ensembl:ENSSSCP00050023878|ensembl:ENSSSCP00055042595|ensembl:ENSSSCP00055042610|ensembl:ENSSSCP00060037487|ensembl:ENSSSCP00065002839|ensembl:ENSSSCP00070043296	intact:EBI-1636616|ensembl:ENSRNOP00000026207	psi-mi:acm2_pig(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kymry et al. (2006)	imex:IM-14647|pubmed:17224084	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2896307|imex:IM-14647-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSSSCG00005019043(gene)|ensembl:ENSSSCG00015037045(gene)|ensembl:ENSSSCG00025009535(gene)|ensembl:ENSSSCG00030065386(gene)|ensembl:ENSSSCG00035013538(gene)|ensembl:ENSSSCG00045023330(gene)|ensembl:ENSSSCG00050041436(gene)|ensembl:ENSSSCG00055027008(gene)|ensembl:ENSSSCG00060063522(gene)|ensembl:ENSSSCG00065004639(gene)|ensembl:ENSSSCG00070025599(gene)|ensembl:ENSSSCT00005029987(transcript)|ensembl:ENSSSCT00005030016(transcript)|ensembl:ENSSSCT00015049354(transcript)|ensembl:ENSSSCT00015049468(transcript)|ensembl:ENSSSCT00025012609(transcript)|ensembl:ENSSSCT00030091367(transcript)|ensembl:ENSSSCT00035017089(transcript)|ensembl:ENSSSCT00045039850(transcript)|ensembl:ENSSSCT00050056187(transcript)|ensembl:ENSSSCT00055053377(transcript)|ensembl:ENSSSCT00055053400(transcript)|ensembl:ENSSSCT00060086672(transcript)|ensembl:ENSSSCT00065006367(transcript)|ensembl:ENSSSCT00070051184(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_999426.1	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	psi-mi:"MI:0469"(intact)	-	-	figure legend:fig 4|agonist:carbachol|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2010/07/26	2014/10/16	rogid:EkkkClL6XYBORNrE1QIHDnxh9Fc9823	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	intact-crc:E8FBE271AB1A137E|rigid:GIBBubZ2G02jIzSkn+lo6rTz25E	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P06199	uniprotkb:P29067	intact:EBI-2898810|ensembl:ENSSSCP00005018264|ensembl:ENSSSCP00005018285|ensembl:ENSSSCP00015019670|ensembl:ENSSSCP00015019722|ensembl:ENSSSCP00025004979|ensembl:ENSSSCP00030042034|ensembl:ENSSSCP00035005909|ensembl:ENSSSCP00045027745|ensembl:ENSSSCP00050023878|ensembl:ENSSSCP00055042595|ensembl:ENSSSCP00055042610|ensembl:ENSSSCP00060037487|ensembl:ENSSSCP00065002839|ensembl:ENSSSCP00070043296	intact:EBI-1636616|ensembl:ENSRNOP00000026207	psi-mi:acm2_pig(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kymry et al. (2006)	imex:IM-14647|pubmed:17224084	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2896355|imex:IM-14647-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSSSCG00005019043(gene)|ensembl:ENSSSCG00015037045(gene)|ensembl:ENSSSCG00025009535(gene)|ensembl:ENSSSCG00030065386(gene)|ensembl:ENSSSCG00035013538(gene)|ensembl:ENSSSCG00045023330(gene)|ensembl:ENSSSCG00050041436(gene)|ensembl:ENSSSCG00055027008(gene)|ensembl:ENSSSCG00060063522(gene)|ensembl:ENSSSCG00065004639(gene)|ensembl:ENSSSCG00070025599(gene)|ensembl:ENSSSCT00005029987(transcript)|ensembl:ENSSSCT00005030016(transcript)|ensembl:ENSSSCT00015049354(transcript)|ensembl:ENSSSCT00015049468(transcript)|ensembl:ENSSSCT00025012609(transcript)|ensembl:ENSSSCT00030091367(transcript)|ensembl:ENSSSCT00035017089(transcript)|ensembl:ENSSSCT00045039850(transcript)|ensembl:ENSSSCT00050056187(transcript)|ensembl:ENSSSCT00055053377(transcript)|ensembl:ENSSSCT00055053400(transcript)|ensembl:ENSSSCT00060086672(transcript)|ensembl:ENSSSCT00065006367(transcript)|ensembl:ENSSSCT00070051184(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_999426.1	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	psi-mi:"MI:0469"(intact)	-	-	agonist:carbachol|figure legend:fig 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-aortic_smooth_muscle)|taxid:10116(rat aortic smooth muscle cells)	-	2010/07/26	2014/10/16	rogid:EkkkClL6XYBORNrE1QIHDnxh9Fc9823	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	intact-crc:5A971E6729527555|rigid:GIBBubZ2G02jIzSkn+lo6rTz25E	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P06199	uniprotkb:P29067	intact:EBI-2898810|ensembl:ENSSSCP00005018264|ensembl:ENSSSCP00005018285|ensembl:ENSSSCP00015019670|ensembl:ENSSSCP00015019722|ensembl:ENSSSCP00025004979|ensembl:ENSSSCP00030042034|ensembl:ENSSSCP00035005909|ensembl:ENSSSCP00045027745|ensembl:ENSSSCP00050023878|ensembl:ENSSSCP00055042595|ensembl:ENSSSCP00055042610|ensembl:ENSSSCP00060037487|ensembl:ENSSSCP00065002839|ensembl:ENSSSCP00070043296	intact:EBI-1636616|ensembl:ENSRNOP00000026207	psi-mi:acm2_pig(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kymry et al. (2006)	imex:IM-14647|pubmed:17224084	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2896323|imex:IM-14647-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSSSCG00005019043(gene)|ensembl:ENSSSCG00015037045(gene)|ensembl:ENSSSCG00025009535(gene)|ensembl:ENSSSCG00030065386(gene)|ensembl:ENSSSCG00035013538(gene)|ensembl:ENSSSCG00045023330(gene)|ensembl:ENSSSCG00050041436(gene)|ensembl:ENSSSCG00055027008(gene)|ensembl:ENSSSCG00060063522(gene)|ensembl:ENSSSCG00065004639(gene)|ensembl:ENSSSCG00070025599(gene)|ensembl:ENSSSCT00005029987(transcript)|ensembl:ENSSSCT00005030016(transcript)|ensembl:ENSSSCT00015049354(transcript)|ensembl:ENSSSCT00015049468(transcript)|ensembl:ENSSSCT00025012609(transcript)|ensembl:ENSSSCT00030091367(transcript)|ensembl:ENSSSCT00035017089(transcript)|ensembl:ENSSSCT00045039850(transcript)|ensembl:ENSSSCT00050056187(transcript)|ensembl:ENSSSCT00055053377(transcript)|ensembl:ENSSSCT00055053400(transcript)|ensembl:ENSSSCT00060086672(transcript)|ensembl:ENSSSCT00065006367(transcript)|ensembl:ENSSSCT00070051184(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_999426.1	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	psi-mi:"MI:0469"(intact)	-	-	agonist:carbachol|figure legend:fig 8 and fig 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/07/26	2014/10/16	rogid:EkkkClL6XYBORNrE1QIHDnxh9Fc9823	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	intact-crc:03CA899E5E014BF7|rigid:GIBBubZ2G02jIzSkn+lo6rTz25E	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P06199	uniprotkb:P29067	intact:EBI-2898810|ensembl:ENSSSCP00005018264|ensembl:ENSSSCP00005018285|ensembl:ENSSSCP00015019670|ensembl:ENSSSCP00015019722|ensembl:ENSSSCP00025004979|ensembl:ENSSSCP00030042034|ensembl:ENSSSCP00035005909|ensembl:ENSSSCP00045027745|ensembl:ENSSSCP00050023878|ensembl:ENSSSCP00055042595|ensembl:ENSSSCP00055042610|ensembl:ENSSSCP00060037487|ensembl:ENSSSCP00065002839|ensembl:ENSSSCP00070043296	intact:EBI-1636616|ensembl:ENSRNOP00000026207	psi-mi:acm2_pig(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kymry et al. (2006)	imex:IM-14647|pubmed:17224084	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2896339|imex:IM-14647-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSSSCG00005019043(gene)|ensembl:ENSSSCG00015037045(gene)|ensembl:ENSSSCG00025009535(gene)|ensembl:ENSSSCG00030065386(gene)|ensembl:ENSSSCG00035013538(gene)|ensembl:ENSSSCG00045023330(gene)|ensembl:ENSSSCG00050041436(gene)|ensembl:ENSSSCG00055027008(gene)|ensembl:ENSSSCG00060063522(gene)|ensembl:ENSSSCG00065004639(gene)|ensembl:ENSSSCG00070025599(gene)|ensembl:ENSSSCT00005029987(transcript)|ensembl:ENSSSCT00005030016(transcript)|ensembl:ENSSSCT00015049354(transcript)|ensembl:ENSSSCT00015049468(transcript)|ensembl:ENSSSCT00025012609(transcript)|ensembl:ENSSSCT00030091367(transcript)|ensembl:ENSSSCT00035017089(transcript)|ensembl:ENSSSCT00045039850(transcript)|ensembl:ENSSSCT00050056187(transcript)|ensembl:ENSSSCT00055053377(transcript)|ensembl:ENSSSCT00055053400(transcript)|ensembl:ENSSSCT00060086672(transcript)|ensembl:ENSSSCT00065006367(transcript)|ensembl:ENSSSCT00070051184(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0045211"(postsynaptic membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_999426.1	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	psi-mi:"MI:0469"(intact)	-	-	figure legend:fig 5|agonist:carbachol|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2010/07/26	2014/10/16	rogid:EkkkClL6XYBORNrE1QIHDnxh9Fc9823	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	intact-crc:334E61FD1BBC7E0A|rigid:GIBBubZ2G02jIzSkn+lo6rTz25E	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)