#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A8K8P3	uniprotkb:P41208	intact:EBI-743371|uniprotkb:A1L373|uniprotkb:A1L387|uniprotkb:A2A2L2|uniprotkb:B1AKL9|uniprotkb:O60289|uniprotkb:Q2TAN8|uniprotkb:Q5W1B5|uniprotkb:Q86TK0|uniprotkb:Q8N8C1|uniprotkb:Q8WU14|uniprotkb:Q8N4U8|uniprotkb:B5MDB7|intact:EBI-2803099|uniprotkb:B7Z1V6|uniprotkb:B7Z8G3|uniprotkb:B7ZBE2|uniprotkb:B7ZBE3|ensembl:ENSP00000383145	intact:EBI-1789926|uniprotkb:Q53XW1|uniprotkb:B2R4T4|ensembl:ENSP00000359300	psi-mi:sfi1_human(display_long)|uniprotkb:KIAA0542(gene name synonym)|uniprotkb:SFI1(gene name)|psi-mi:SFI1(display_short)	psi-mi:cetn2_human(display_long)|uniprotkb:CETN2(gene name)|psi-mi:CETN2(display_short)|uniprotkb:CALT(gene name synonym)|uniprotkb:CEN2(gene name synonym)|uniprotkb:Caltractin isoform 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Juan et al. (2006)	pubmed:16956364|imex:IM-20476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2659498|imex:IM-20476-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245254.1|refseq:NP_001245255.1|refseq:NP_001245256.1|refseq:NP_001007468.1|refseq:NP_055590.2|ensembl:ENSG00000198089(gene)|ensembl:ENST00000400288(transcript)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0019902"(phosphatase binding)|interpro:IPR030516|mint:A8K8P3|rcsb pdb:2K2I|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_006724453.1|refseq:XP_016884640.1|refseq:XP_016884643.1	refseq:NP_004335.1|ensembl:ENSG00000147400(gene)|ensembl:ENST00000370277(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007099"(centriole replication)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045177"(apical part of cell)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0071942"(XPC complex)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR037629|rcsb pdb:1M39|rcsb pdb:1ZMZ|rcsb pdb:2A4J|rcsb pdb:2GGM|rcsb pdb:2K2I|rcsb pdb:2OBH|reactome:R-HSA-2565942|reactome:R-HSA-3108214|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-8854518	-	-	-	figure legend:Fig 2 and Fig 3|comment:"KA for Cen2 (94-172) binding SFI1 (641-660)  = 14.1E6 M-1, for Cen2 binding SFI1 (641-660)  =  6.5E6 M-1, for Cen2 (94-172) binding SFI1 (111-130) = 22.3E6 M-1, for Cen2 binding SFI1 (111-130) =  8E6 M-1 and Cen2 binding SFI1 (475-494) =  0.01 M-1"|stimulant:calcium|comment:"titration of R17(641-660)-hSfi1 into HsCen2 and C-HsCen2, R1(111-130)-hSfi1 into HsCen2 and C-HsCen2 and R12(475-494)-hSfi1 repeat into HsCen2 were investigated using isothermal titration calorimetry"|kinetic_conditions:pH 7.4, Temp=30C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:1.0x10^7(molar)	2010/05/17	2014/10/16	rogid:hNob4sTZSjcaRJJr1FFkHj9leWY9606	rogid:gOH/cxPm4HW7g94+UYIAAipqXyg9606	intact-crc:4B09A28948556E60|rigid:ik8btJlWOP7sWwJNGrzLzoPmnYY	false	sufficient binding region:641-660|sufficient binding region:475-494|sufficient binding region:111-130	sufficient binding region:94-172	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A8K8P3	uniprotkb:P41208	intact:EBI-743371|uniprotkb:A1L373|uniprotkb:A1L387|uniprotkb:A2A2L2|uniprotkb:B1AKL9|uniprotkb:O60289|uniprotkb:Q2TAN8|uniprotkb:Q5W1B5|uniprotkb:Q86TK0|uniprotkb:Q8N8C1|uniprotkb:Q8WU14|uniprotkb:Q8N4U8|uniprotkb:B5MDB7|intact:EBI-2803099|uniprotkb:B7Z1V6|uniprotkb:B7Z8G3|uniprotkb:B7ZBE2|uniprotkb:B7ZBE3|ensembl:ENSP00000383145	intact:EBI-1789926|uniprotkb:Q53XW1|uniprotkb:B2R4T4|ensembl:ENSP00000359300	psi-mi:sfi1_human(display_long)|uniprotkb:KIAA0542(gene name synonym)|uniprotkb:SFI1(gene name)|psi-mi:SFI1(display_short)	psi-mi:cetn2_human(display_long)|uniprotkb:CETN2(gene name)|psi-mi:CETN2(display_short)|uniprotkb:CALT(gene name synonym)|uniprotkb:CEN2(gene name synonym)|uniprotkb:Caltractin isoform 1(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	Juan et al. (2006)	pubmed:16956364|imex:IM-20476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2659522|imex:IM-20476-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245254.1|refseq:NP_001245255.1|refseq:NP_001245256.1|refseq:NP_001007468.1|refseq:NP_055590.2|ensembl:ENSG00000198089(gene)|ensembl:ENST00000400288(transcript)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0019902"(phosphatase binding)|interpro:IPR030516|mint:A8K8P3|rcsb pdb:2K2I|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_006724453.1|refseq:XP_016884640.1|refseq:XP_016884643.1	refseq:NP_004335.1|ensembl:ENSG00000147400(gene)|ensembl:ENST00000370277(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007099"(centriole replication)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045177"(apical part of cell)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0071942"(XPC complex)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR037629|rcsb pdb:1M39|rcsb pdb:1ZMZ|rcsb pdb:2A4J|rcsb pdb:2GGM|rcsb pdb:2K2I|rcsb pdb:2OBH|reactome:R-HSA-2565942|reactome:R-HSA-3108214|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-8854518	-	-	-	figure legend:Fig 4|stimulant:calcium|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/17	2014/10/16	rogid:hNob4sTZSjcaRJJr1FFkHj9leWY9606	rogid:gOH/cxPm4HW7g94+UYIAAipqXyg9606	intact-crc:14A7E0DF8C5BFDCA|rigid:ik8btJlWOP7sWwJNGrzLzoPmnYY	false	sufficient binding region:641-660	sufficient binding region:94-172	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41208	uniprotkb:A8K8P3	intact:EBI-1789926|uniprotkb:Q53XW1|uniprotkb:B2R4T4|ensembl:ENSP00000359300	intact:EBI-743371|uniprotkb:A1L373|uniprotkb:A1L387|uniprotkb:A2A2L2|uniprotkb:B1AKL9|uniprotkb:O60289|uniprotkb:Q2TAN8|uniprotkb:Q5W1B5|uniprotkb:Q86TK0|uniprotkb:Q8N8C1|uniprotkb:Q8WU14|uniprotkb:Q8N4U8|uniprotkb:B5MDB7|intact:EBI-2803099|uniprotkb:B7Z1V6|uniprotkb:B7Z8G3|uniprotkb:B7ZBE2|uniprotkb:B7ZBE3|ensembl:ENSP00000383145	psi-mi:cetn2_human(display_long)|uniprotkb:CETN2(gene name)|psi-mi:CETN2(display_short)|uniprotkb:CALT(gene name synonym)|uniprotkb:CEN2(gene name synonym)|uniprotkb:Caltractin isoform 1(gene name synonym)	psi-mi:sfi1_human(display_long)|uniprotkb:KIAA0542(gene name synonym)|uniprotkb:SFI1(gene name)|psi-mi:SFI1(display_short)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Juan et al. (2006)	pubmed:16956364|imex:IM-20476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2659539|imex:IM-20476-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004335.1|ensembl:ENSG00000147400(gene)|ensembl:ENST00000370277(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007099"(centriole replication)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045177"(apical part of cell)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0071942"(XPC complex)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR037629|rcsb pdb:1M39|rcsb pdb:1ZMZ|rcsb pdb:2A4J|rcsb pdb:2GGM|rcsb pdb:2K2I|rcsb pdb:2OBH|reactome:R-HSA-2565942|reactome:R-HSA-3108214|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-8854518	refseq:NP_001245254.1|refseq:NP_001245255.1|refseq:NP_001245256.1|refseq:NP_001007468.1|refseq:NP_055590.2|ensembl:ENSG00000198089(gene)|ensembl:ENST00000400288(transcript)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0019902"(phosphatase binding)|interpro:IPR030516|mint:A8K8P3|rcsb pdb:2K2I|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_006724453.1|refseq:XP_016884640.1|refseq:XP_016884643.1	-	-	-	figure legend:Fig 5|stimulant:calcium|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kon:1.5x10^6(molar)	2010/05/17	2014/10/16	rogid:gOH/cxPm4HW7g94+UYIAAipqXyg9606	rogid:hNob4sTZSjcaRJJr1FFkHj9leWY9606	intact-crc:7E02122BA1BD4265|rigid:ik8btJlWOP7sWwJNGrzLzoPmnYY	false	sufficient binding region:94-172	sufficient binding region:641-660	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41208	uniprotkb:A8K8P3	intact:EBI-1789926|uniprotkb:Q53XW1|uniprotkb:B2R4T4|ensembl:ENSP00000359300	intact:EBI-743371|uniprotkb:A1L373|uniprotkb:A1L387|uniprotkb:A2A2L2|uniprotkb:B1AKL9|uniprotkb:O60289|uniprotkb:Q2TAN8|uniprotkb:Q5W1B5|uniprotkb:Q86TK0|uniprotkb:Q8N8C1|uniprotkb:Q8WU14|uniprotkb:Q8N4U8|uniprotkb:B5MDB7|intact:EBI-2803099|uniprotkb:B7Z1V6|uniprotkb:B7Z8G3|uniprotkb:B7ZBE2|uniprotkb:B7ZBE3|ensembl:ENSP00000383145	psi-mi:cetn2_human(display_long)|uniprotkb:CETN2(gene name)|psi-mi:CETN2(display_short)|uniprotkb:CALT(gene name synonym)|uniprotkb:CEN2(gene name synonym)|uniprotkb:Caltractin isoform 1(gene name synonym)	psi-mi:sfi1_human(display_long)|uniprotkb:KIAA0542(gene name synonym)|uniprotkb:SFI1(gene name)|psi-mi:SFI1(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Juan et al. (2006)	pubmed:16956364|imex:IM-20476	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2659557|imex:IM-20476-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004335.1|ensembl:ENSG00000147400(gene)|ensembl:ENST00000370277(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007099"(centriole replication)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045177"(apical part of cell)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0071942"(XPC complex)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR037629|rcsb pdb:1M39|rcsb pdb:1ZMZ|rcsb pdb:2A4J|rcsb pdb:2GGM|rcsb pdb:2K2I|rcsb pdb:2OBH|reactome:R-HSA-2565942|reactome:R-HSA-3108214|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-8854518	refseq:NP_001245254.1|refseq:NP_001245255.1|refseq:NP_001245256.1|refseq:NP_001007468.1|refseq:NP_055590.2|ensembl:ENSG00000198089(gene)|ensembl:ENST00000400288(transcript)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0019902"(phosphatase binding)|interpro:IPR030516|mint:A8K8P3|rcsb pdb:2K2I|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_006724453.1|refseq:XP_016884640.1|refseq:XP_016884643.1	-	-	-	figure legend:Fig 6|stimulant:calcium|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/17	2014/10/16	rogid:gOH/cxPm4HW7g94+UYIAAipqXyg9606	rogid:hNob4sTZSjcaRJJr1FFkHj9leWY9606	intact-crc:BB8F1AA66235F239|rigid:ik8btJlWOP7sWwJNGrzLzoPmnYY	false	sufficient binding region:94-172	sufficient binding region:641-660	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)