#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35282	uniprotkb:P17301	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2623938|imex:IM-20461-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	intact-crc:80DE6477A5FCFA02|rigid:WcZQbdpIQ12BBC1nYvnEM/zbc9Q	false	-	sufficient binding region:1153-1181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35282	uniprotkb:P17301	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2623986|imex:IM-20461-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	-	-	-	figure legend:fig. 1. A|antibodies:specific antibody against integrin alpha2 for the western blot|caution:The authors said that GFP-tagged Rab21 coprecipitated with alpa2 beta1-integrin but they used only antibodies against alpha2-integrin for the western blot|delivery method:P35282 transfection|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	intact-crc:BA7114B550832855|rigid:WcZQbdpIQ12BBC1nYvnEM/zbc9Q	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35282	intact:EBI-2624041	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	-	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:integrin-a2-1_human(display_short)|psi-mi:EBI-2624041(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624078|imex:IM-20461-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	uniprotkb:P17301(multiple parent)|uniprotkb:P56199(multiple parent)|pubmed:10525544(see-also)	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:fig. 1. B|antibodies:specific antibody against integrin alpha2 for the immunoprecipitation|delivery method:EBI-2624041; P35282 transfection|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-saos-2)|taxid:9606(Homo sapiens SAOS-2 cell line established from primary osteogenic sarcoma)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	-	intact-crc:3A61D5F3E9D32279	false	renilla luciferase protein tag:?-?|mutation increasing interaction:76-76	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35282	uniprotkb:P05556	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624119|imex:IM-20461-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	-	-	-	figure legend:fig. 1. B|antibodies:specific antibody against integrin beta1 for the immunoprecipitation|delivery method:P35282 transfection|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-saos-2)|taxid:9606(Homo sapiens SAOS-2 cell line established from primary osteogenic sarcoma)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:91A106182809FE61|rigid:iYYK+RjC1uBv9IUjY7yebpMGaCw	false	renilla luciferase protein tag:?-?|mutation increasing interaction:76-76	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35282	intact:EBI-2624056	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	-	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:integrin-a2-5_human(display_short)|psi-mi:EBI-2624056(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624129|imex:IM-20461-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	uniprotkb:P17301(multiple parent)|uniprotkb:P08648(multiple parent)|pubmed:1547502(see-also)	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:fig. 1. B|antibodies:specific antibody against integrin alpha2 for the immunoprecipitation|delivery method:EBI-2624056; P35282 transfection|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-saos-2)|taxid:9606(Homo sapiens SAOS-2 cell line established from primary osteogenic sarcoma)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	-	intact-crc:55F081F393E8B42C	false	renilla luciferase protein tag:?-?|mutation increasing interaction:76-76	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35282	uniprotkb:P05556	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624148|imex:IM-20461-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	-	-	-	figure legend:fig. 1. C and supplementary table S1|antibodies:specific antibody against integrin beta1 for the immunoprecipitation|delivery method:P35282 transfection|comment:The mutant Rab21c-del which is composed of the residues 1 to 144 of the full length Rab21 is weakly interacting with interactin beta. The residues 95 to 144 seem to be sufficient to bind.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:C12F81DAC0F3C55B|rigid:iYYK+RjC1uBv9IUjY7yebpMGaCw	false	renilla luciferase protein tag:?-?|mutation decreasing interaction:31-31|sufficient binding region:95-222|mutation increasing interaction:76-76	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35282	uniprotkb:P17301	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624156|imex:IM-20461-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	-	-	-	figure legend:Supplementary table S1|antibodies:specific antibody against integrin alpha2 for the immunoprecipitation|delivery method:P35282 transfection|comment:The mutant Rab21c-del which is composed of the residues 1 to 144 of the full length Rab21 is weakly interacting with interactin alpha. The residues 95 to 144 seem to be sufficient to bind.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	intact-crc:141F8A071A81A82E|rigid:WcZQbdpIQ12BBC1nYvnEM/zbc9Q	false	renilla luciferase protein tag:?-?|mutation increasing interaction:76-76|mutation decreasing interaction:31-31|sufficient binding region:95-222	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35282	uniprotkb:P17301	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624260|imex:IM-20461-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	-	-	-	figure legend:fig. 1. E|delivery method:P17301; P35282 transfection|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	intact-crc:6A74F069B0DA702B|rigid:WcZQbdpIQ12BBC1nYvnEM/zbc9Q	false	renilla luciferase protein tag:?-?	green fluorescent protein tag:?-?|mutation decreasing interaction:1160-1161|mutation decreasing interaction:1162-1162|mutation decreasing interaction:1164-1165,1160-1161	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9UL25	uniprotkb:P05556	intact:EBI-1056039|uniprotkb:Q14466|uniprotkb:Q569H3|ensembl:ENSP00000261263	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:rab21_human(display_long)|uniprotkb:RAB21(gene name)|psi-mi:RAB21(display_short)|uniprotkb:KIAA0118(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624299|imex:IM-20461-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055814.1|ensembl:ENSG00000080371(gene)|ensembl:ENST00000261263(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0005829"(cytosol)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:Q9UL25|rcsb pdb:1YZT|rcsb pdb:1YZU|rcsb pdb:1Z08|rcsb pdb:1Z0I|rcsb pdb:2OT3|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-29349N	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	-	-	-	figure legend:fig. 1. F and Fig. 3. A|antibodies:specific antibody against Rab21 for the immunoprecipitation and specific antibody against integrin beta1 for the western blot|comment:beta integrin associate with Rab21 mainly after internalization|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2010/03/24	2014/10/16	rogid:xeTabB1AP4LZcYhU4u/vZwwETnA9606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:CF71A7B92130A0BB|rigid:F28WBHnhiidVsPk10hGKTh5zSpw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20339	uniprotkb:P05556	intact:EBI-399437|uniprotkb:B4DJA5|intact:EBI-1048179|uniprotkb:Q6FI44|ensembl:ENSP00000273047	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:rab5a_human(display_long)|uniprotkb:RAB5A(gene name)|psi-mi:RAB5A(display_short)|uniprotkb:RAB5(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624307|imex:IM-20461-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004153.2|refseq:NP_001278977.1|dip:DIP-380N|ensembl:ENSG00000144566(gene)|ensembl:ENST00000273047(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20339|rcsb pdb:1N6H|rcsb pdb:1N6I|rcsb pdb:1N6K|rcsb pdb:1N6L|rcsb pdb:1N6N|rcsb pdb:1N6O|rcsb pdb:1N6P|rcsb pdb:1N6R|rcsb pdb:1R2Q|rcsb pdb:1TU3|rcsb pdb:1TU4|rcsb pdb:3MJH|rcsb pdb:4Q9U|rcsb pdb:7BL1|reactome:R-HSA-1660499|reactome:R-HSA-8854214|reactome:R-HSA-8856828|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9636383|reactome:R-HSA-983231	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	-	-	-	figure legend:fig. 1. F and Fig. 3. A|antibodies:specific antibody against Rab5 for the immunoprecipitation and specific antibody against integrin beta1 for the western blot|comment:beta integrin associate with Rab5 mainly after internalization|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2010/03/24	2014/10/16	rogid:SgowwV7QSVCvfsqSDE+6CHmPmKA9606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:61E248D16194AFEC|rigid:C/c6puBlZxfauINbXc3HTSRlSbU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35282	uniprotkb:P17301	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624736|imex:IM-20461-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	-	-	-	figure legend:fig. 3. D|delivery method:P35282 transfection|comment:"GFP-Rab21 cofractionned with alpha 2 integrin in fractions 3 to 9. The mutant gln76leu-Rab21 cofractionned with alpha 2 integrin in fractions 5 to 11 (denser fractions) and thr31asn-Rab21 cofractionned with alpha 2 integrin in fractions 4 to 8."|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	intact-crc:D979F74754A37A0E|rigid:WcZQbdpIQ12BBC1nYvnEM/zbc9Q	false	green fluorescent protein tag:?-?|mutation increasing interaction:76-76|mutation decreasing interaction:31-31	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35282	uniprotkb:P05556	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624800|imex:IM-20461-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191	-	-	-	figure legend:Fig. 5. A|antibodies:specific antibody against integrin beta for the immunoprecipitation and|delivery method:P35282 transfection|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:63608AFF85C181CF|rigid:iYYK+RjC1uBv9IUjY7yebpMGaCw	false	renilla luciferase protein tag:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35282	uniprotkb:P17301	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624818|imex:IM-20461-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	-	-	-	figure legend:fig. 5. A|delivery method:P35282; P17301 transfection|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	intact-crc:7581D6661CC9AC6C|rigid:WcZQbdpIQ12BBC1nYvnEM/zbc9Q	false	renilla luciferase protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35282	uniprotkb:Q9UKX5	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-2568019|uniprotkb:Q8WYI8|uniprotkb:Q9UKQ1|ensembl:ENSP00000327290|uniprotkb:J3KQM2	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:ita11_human(display_long)|uniprotkb:ITGA11(gene name)|psi-mi:ITGA11(display_short)|uniprotkb:MSTP018(orf name)	psi-mi:"MI:0018"(two hybrid)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2624204|imex:IM-20461-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	refseq:NP_001004439.1|ensembl:ENSG00000137809(gene)|ensembl:ENST00000315757(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005518"(collagen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008305"(integrin complex)|go:"GO:0016020"(membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|reactome:R-HSA-216083	-	-	-	figure legend:fig. 1. D|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:tFyxZTYEQ8Mo17+AUVUWFioPgFo9606	intact-crc:032141361404B95F|rigid:MfUmuAJluzgt0EvTnvmzvZ04siM	false	sufficient binding region:95-222	sufficient binding region:1164-1188	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35282	uniprotkb:P17301	intact:EBI-1993555|uniprotkb:Q7TPN7|ensembl:ENSMUSP00000020343	intact:EBI-702960|ensembl:ENSP00000296585|uniprotkb:Q14595	psi-mi:rab21_mouse(display_long)|uniprotkb:Rab21(gene name)|psi-mi:Rab21(display_short)|uniprotkb:Rab-12(gene name synonym)	psi-mi:ita2_human(display_long)|uniprotkb:Platelet membrane glycoprotein Ia(gene name synonym)|uniprotkb:Collagen receptor(gene name synonym)|uniprotkb:VLA-2 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member B(gene name synonym)|uniprotkb:ITGA2(gene name)|psi-mi:ITGA2(display_short)|uniprotkb:CD49B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pellinen et al. (2006)	pubmed:16754960|imex:IM-20461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2638310|imex:IM-20461-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077774.1|ensembl:ENSMUSG00000020132(gene)|ensembl:ENSMUST00000020343(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:P35282|reactome:R-MMU-8873719|reactome:R-MMU-8876198	ensembl:ENSG00000164171(gene)|ensembl:ENST00000296585(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0006971"(hypotonic response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014075"(response to amine)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033343"(positive regulation of collagen binding)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0038064"(collagen receptor activity)|go:"GO:0038065"(collagen-activated signaling pathway)|go:"GO:0042493"|go:"GO:0043236"(laminin binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|mint:P17301|rcsb pdb:1AOX|rcsb pdb:1DZI|rcsb pdb:1PQB|rcsb pdb:1V7P|rcsb pdb:4BJ3|rcsb pdb:5HJ2|rcsb pdb:5THP|rcsb pdb:6ND8|rcsb pdb:6ND9|rcsb pdb:6NDA|rcsb pdb:6NDB|rcsb pdb:6NDC|rcsb pdb:6NDD|rcsb pdb:6NDE|rcsb pdb:6NDF|rcsb pdb:6NDG|rcsb pdb:6NDH|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-447041|reactome:R-HSA-75892|reactome:R-HSA-8874081|refseq:NP_002194.2|dip:DIP-67N	-	-	-	figure legend:fig. 1. D|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/03/24	2014/10/16	rogid:LutxdtFI7bIYCtGadJaQ5DdohYY10090	rogid:+18cfTauTEyc6MdRfGpHYfDNEpk9606	intact-crc:8EFC665088344E82|rigid:WcZQbdpIQ12BBC1nYvnEM/zbc9Q	false	sufficient binding region:95-222	sufficient binding region:1153-1181|mutation decreasing interaction:1162-1162|mutation decreasing interaction:1160-1161|mutation decreasing interaction:1162-1162,1159-1160|mutation decreasing interaction:1164-1165,1160-1161	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)