#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62985	uniprotkb:P07949	intact:EBI-7395583|uniprotkb:O55072|intact:MINT-1528512|ensembl:ENSRNOP00000066048	intact:EBI-2480756|intact:EBI-28967738|ensembl:ENSP00000347942|uniprotkb:A8K6Z2|uniprotkb:Q9BTB0|uniprotkb:Q15250|uniprotkb:Q9H4A2	psi-mi:sh2b1_rat(display_long)|uniprotkb:Sh2b1(gene name)|psi-mi:Sh2b1(display_short)|uniprotkb:Sh2-b(gene name synonym)|uniprotkb:Sh2bpsm1(gene name synonym)|uniprotkb:SH2 domain-containing protein 1B(gene name synonym)|uniprotkb:SH2-B PH domain-containing signaling mediator 1(gene name synonym)|uniprotkb:FceRI gamma-chain-interacting protein SH2-B(gene name synonym)	psi-mi:ret_human(display_long)|uniprotkb:RET(gene name)|psi-mi:RET(display_short)|uniprotkb:CDHF12(gene name synonym)|uniprotkb:Cadherin family member 12(gene name synonym)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)|uniprotkb:CDHR16(gene name synonym)|uniprotkb:PTC(gene name synonym)|uniprotkb:RET51(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2006)	pubmed:16569669|mint:MINT-6731754	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8278977|mint:MINT-8034213	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001041645.1|refseq:NP_604451.2|rgd:620132|refseq:XP_006230415.1|refseq:XP_006230416.1|ensembl:ENSRNOG00000049181(gene)|ensembl:ENSRNOT00000074274(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:2000278"(regulation of DNA biosynthetic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015012(Phenylalanine zipper)|interpro:IPR030521|interpro:IPR030523|interpro:IPR035057|go:"GO:0045840"(positive regulation of mitotic nuclear division)|interpro:IPR036290|interpro:IPR036860|reactome:R-RNO-1170546|reactome:R-RNO-982772|reactome:R-RNO-983231|mint:MINT-8034214(identity)|uniprotkb:Q62985(original identifier)	ensembl:ENSG00000165731(gene)|ensembl:ENST00000355710(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007497"(posterior midgut development)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|go:"GO:0098797"(plasma membrane protein complex)|mint:P07949|rcsb pdb:1XPD|rcsb pdb:2IVS|rcsb pdb:2IVT|rcsb pdb:2IVU|rcsb pdb:2IVV|rcsb pdb:2X2K|rcsb pdb:2X2L|rcsb pdb:2X2M|rcsb pdb:2X2U|rcsb pdb:4CKI|go:"GO:0035799"(ureter maturation)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0097021"(lymphocyte migration into lymphoid organs)|go:"GO:0033674"(positive regulation of kinase activity)|rcsb pdb:4UX8|rcsb pdb:5AMN|rcsb pdb:5FM2|rcsb pdb:5FM3|rcsb pdb:6FEK|rcsb pdb:6GL7|rcsb pdb:6I82|rcsb pdb:6I83|rcsb pdb:6NE7|rcsb pdb:6NEC|rcsb pdb:6NJA|rcsb pdb:6Q2J|rcsb pdb:6Q2N|rcsb pdb:6Q2O|rcsb pdb:6Q2R|rcsb pdb:4CKJ|rcsb pdb:6Q2S|rcsb pdb:6VHG|rcsb pdb:7JU5|rcsb pdb:7JU6|reactome:R-HSA-5673001|reactome:R-HSA-8853659|ensembl:ENST00000340058|ensembl:ENSP00000344798|ensembl:ENSP00000347942|refseq:NP_065681.1|refseq:NP_066124.1|dip:DIP-41449N|mint:MINT-8034217(identity)|uniprotkb:P07949(original identifier)	-	function:"Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis"|comment:mint	-	comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2014/10/16	rogid:r62jAGzJM3KQ8JltRzfnDFh5e0o10116	rogid:vNKdBK5ZYchweyidTdbDFkd02VM9606	intact-crc:B0BBBB510D2BDDC3|rigid:vhqYe7W6uHy75VlUOXe3ygvdqwU	false	-	binding-associated region:974-987(MINT-8034220)|phosphorylated residue:981-981(MINT-8034222)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)