#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30542	uniprotkb:P29274	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ciruela et al. (2006)	pubmed:16481441|imex:IM-20501	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2904802|imex:IM-20501-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	-	-	-	figure legend:Fig. 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/08/09	2014/10/16	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	intact-crc:4C102A69E932125E|rigid:v2TeHbF8HfCjQS738yY6AAYHU+A	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29274	uniprotkb:P30542	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ciruela et al. (2006)	pubmed:16481441|imex:IM-20501	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2904883|imex:IM-20501-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	-	-	-	figure legend:Fig. 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/08/09	2014/10/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	intact-crc:08285A98928A6648|rigid:v2TeHbF8HfCjQS738yY6AAYHU+A	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30542	uniprotkb:P29274	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Ciruela et al. (2006)	pubmed:16481441|imex:IM-20501	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2904906|imex:IM-20501-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	-	-	-	figure legend:Fig. 1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/08/09	2014/10/16	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	intact-crc:1EC92D824AA67B14|rigid:v2TeHbF8HfCjQS738yY6AAYHU+A	false	yellow fluorescent protein tag:?-?	renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P29274	uniprotkb:P30542	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Ciruela et al. (2006)	pubmed:16481441|imex:IM-20501	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2904959|imex:IM-20501-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	-	-	-	figure legend:Fig. 1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/08/09	2014/10/16	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	intact-crc:8894B1CC3614C786|rigid:v2TeHbF8HfCjQS738yY6AAYHU+A	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P25099	uniprotkb:P30543	intact:EBI-2905080|ensembl:ENSRNOP00000004602|ensembl:ENSRNOP00000073958	intact:EBI-2902822|ensembl:ENSRNOP00000001759	psi-mi:aa1r_rat(display_long)|uniprotkb:Adora1(gene name)|psi-mi:Adora1(display_short)	psi-mi:aa2ar_rat(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:"MI:0040"(electron microscopy)	Ciruela et al. (2006)	pubmed:16481441|imex:IM-20501	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2905139|imex:IM-20501-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044297"(cell body)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-418594|ensembl:ENSRNOG00000003442(gene)|ensembl:ENSRNOT00000004602(transcript)|ensembl:ENSRNOT00000078993(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042311"(vasodilation)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0005783"(endoplasmic reticulum)|rgd:2048|refseq:NP_058851.2|refseq:XP_006249921.1|refseq:XP_006249923.1	ensembl:ENSRNOG00000001302(gene)|ensembl:ENSRNOT00000001759(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-5683826|go:"GO:0043116"(negative regulation of vascular permeability)|rgd:2049|refseq:NP_445746.3|refseq:XP_017457041.1|refseq:XP_017457042.1|refseq:XP_017457043.1|refseq:XP_017457044.1	go:"GO:0042734"(presynaptic membrane)	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-striatum)|taxid:10116(Rattus norvegicus brian stiatum)	-	2010/08/09	2014/10/16	rogid:2JgyElmUGLZ0s/hJ7oLo6ycCo5Q10116	rogid:sXgn+A8OWk43DSsggsiGWPmC8gk10116	intact-crc:A8EBD076A72AEF00|rigid:hR3rw4Rkqxzn/EztN1VFpBycfbc	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P30543	uniprotkb:P25099	intact:EBI-2902822|ensembl:ENSRNOP00000001759	intact:EBI-2905080|ensembl:ENSRNOP00000004602|ensembl:ENSRNOP00000073958	psi-mi:aa2ar_rat(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:aa1r_rat(display_long)|uniprotkb:Adora1(gene name)|psi-mi:Adora1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Ciruela et al. (2006)	pubmed:16481441|imex:IM-20501	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2905272|imex:IM-20501-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000001302(gene)|ensembl:ENSRNOT00000001759(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-5683826|go:"GO:0043116"(negative regulation of vascular permeability)|rgd:2049|refseq:NP_445746.3|refseq:XP_017457041.1|refseq:XP_017457042.1|refseq:XP_017457043.1|refseq:XP_017457044.1	go:"GO:0044297"(cell body)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-418594|ensembl:ENSRNOG00000003442(gene)|ensembl:ENSRNOT00000004602(transcript)|ensembl:ENSRNOT00000078993(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042311"(vasodilation)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0005783"(endoplasmic reticulum)|rgd:2048|refseq:NP_058851.2|refseq:XP_006249921.1|refseq:XP_006249923.1	go:"GO:0032279"(asymmetric synapse)	-	-	figure legend:Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-striatum)|taxid:10116(Rattus norvegicus brian stiatum)	-	2010/08/09	2014/10/16	rogid:sXgn+A8OWk43DSsggsiGWPmC8gk10116	rogid:2JgyElmUGLZ0s/hJ7oLo6ycCo5Q10116	intact-crc:9175B62A6BF26AC7|rigid:hR3rw4Rkqxzn/EztN1VFpBycfbc	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P30543	uniprotkb:P25099	intact:EBI-2902822|ensembl:ENSRNOP00000001759	intact:EBI-2905080|ensembl:ENSRNOP00000004602|ensembl:ENSRNOP00000073958	psi-mi:aa2ar_rat(display_long)|uniprotkb:Adora2a(gene name)|psi-mi:Adora2a(display_short)	psi-mi:aa1r_rat(display_long)|uniprotkb:Adora1(gene name)|psi-mi:Adora1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ciruela et al. (2006)	pubmed:16481441|imex:IM-20501	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2905309|imex:IM-20501-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000001302(gene)|ensembl:ENSRNOT00000001759(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-5683826|go:"GO:0043116"(negative regulation of vascular permeability)|rgd:2049|refseq:NP_445746.3|refseq:XP_017457041.1|refseq:XP_017457042.1|refseq:XP_017457043.1|refseq:XP_017457044.1	go:"GO:0044297"(cell body)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-418594|ensembl:ENSRNOG00000003442(gene)|ensembl:ENSRNOT00000004602(transcript)|ensembl:ENSRNOT00000078993(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042311"(vasodilation)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0005783"(endoplasmic reticulum)|rgd:2048|refseq:NP_058851.2|refseq:XP_006249921.1|refseq:XP_006249923.1	-	-	-	figure legend:Fig. 5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-striatum)|taxid:10116(Rattus norvegicus brian stiatum)	-	2010/08/09	2014/10/16	rogid:sXgn+A8OWk43DSsggsiGWPmC8gk10116	rogid:2JgyElmUGLZ0s/hJ7oLo6ycCo5Q10116	intact-crc:394371D414E36060|rigid:hR3rw4Rkqxzn/EztN1VFpBycfbc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)