#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99683	uniprotkb:O15524	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	He et al. (2006)	pubmed:16407264|mint:MINT-6731734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7998078|mint:MINT-8034827	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580|mint:MINT-8034831(identity)|uniprotkb:Q99683(original identifier)	go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N|mint:MINT-8034828(identity)|uniprotkb:O15524(original identifier)	-	-	-	comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2014/10/16	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606	intact-crc:0BA6A3A42A5A1D80|rigid:/6X4QDdBZkDrVyjzVNETKulxrGs	false	binding-associated region:711-724(MINT-8034834)|phosphorylated residue:718-718(MINT-8034836)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)