#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O15357 uniprotkb:O60504-1 intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229 intact:EBI-1222953|ensembl:ENSP00000240123|intact:EBI-8565375|intact:MINT-262503|intact:EBI-7905024|intact:EBI-7271420 psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym) psi-mi:o60504-1(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Paternotte et al. (2005) pubmed:16302969|imex:IM-11616|mint:MINT-6671489|doi:10.1111/j.1742-4658.2005.04996 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7904967|mint:MINT-8078922|imex:IM-11616-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526|mint:MINT-8078924(identity) ensembl:ENSG00000120896(gene)|ensembl:ENST00000240123(transcript)|intact:EBI-741237(vinex_human) - - - figure legend:f1a f1b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2010/12/10 2014/10/16 rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606 rogid:Mq3VXduU/1gqfUwliO9sBBOb/Vc9606 intact-crc:377E19804B4ED975|rigid:3n2Vgk4Uie0W0uA3hnhZQz7KQfk false binding-associated region:956-1248(MINT-8078930)|fusion protein:?-?(MINT-8078927) fusion protein:?-?|sufficient binding region:328-671 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60504-1 uniprotkb:O15357 intact:EBI-1222953|ensembl:ENSP00000240123|intact:EBI-8565375|intact:MINT-262503|intact:EBI-7905024|intact:EBI-7271420 intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229 psi-mi:o60504-1(display_long)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Paternotte et al. (2005) pubmed:16302969|imex:IM-11616|mint:MINT-6671489|doi:10.1111/j.1742-4658.2005.04996 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7905019|mint:MINT-8078944|imex:IM-11616-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120896(gene)|ensembl:ENST00000240123(transcript)|intact:EBI-741237(vinex_human)|mint:MINT-8078947(identity) ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526|mint:MINT-8078946(identity) - - - comment:homomint|comment:mint|figure legend:f2b f2d f8b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/12/10 2014/10/16 rogid:Mq3VXduU/1gqfUwliO9sBBOb/Vc9606 rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606 intact-crc:FF698BA65428F83D|rigid:3n2Vgk4Uie0W0uA3hnhZQz7KQfk false ha tag:?-?(MINT-8078953) binding-associated region:892-1258(MINT-8079000)|his tag:?-?(MINT-8078949) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6P549 uniprotkb:Q9R1Z8 intact:EBI-2642932|uniprotkb:Q9JLL7|uniprotkb:Q80YB9|uniprotkb:O08611|uniprotkb:Q0VDX5|ensembl:ENSMUSP00000048057|ensembl:ENSMUSP00000132883 intact:EBI-6673512|ensembl:ENSMUSP00000022682|uniprotkb:Q62423 psi-mi:ship2_mouse(display_long)|uniprotkb:Inppl1(gene name)|psi-mi:Inppl1(display_short)|uniprotkb:Ship2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:AblSH3-binding protein(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym) psi-mi:vinex_mouse(display_long)|uniprotkb:Sorbs3(gene name)|psi-mi:Sorbs3(display_short)|uniprotkb:Scam1(gene name synonym)|uniprotkb:Sh3d4(gene name synonym)|uniprotkb:SH3 domain-containing protein SH3P3(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paternotte et al. (2005) pubmed:16302969|imex:IM-11616|mint:MINT-6671489|doi:10.1111/j.1742-4658.2005.04996 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7905061|mint:MINT-8078962|imex:IM-11616-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011239984.1|refseq:NP_001116211.1|refseq:NP_034697.2|refseq:XP_006507454.1|ensembl:ENSMUSG00000032737(gene)|ensembl:ENSMUST00000035836(transcript)|ensembl:ENSMUST00000165052(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:Q6P549|rcsb pdb:5ZRX|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-912526|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|refseq:XP_017177480.1|mint:MINT-8078964(identity) ensembl:ENSMUSG00000022091(gene)|ensembl:ENSMUST00000022682(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR028510|interpro:IPR035607|interpro:IPR035608|interpro:IPR035609|interpro:IPR036028|mint:Q9R1Z8|go:"GO:0005856"(cytoskeleton)|reactome:R-MMU-445355|refseq:NP_035496.1|mint:MINT-8078965(identity) - - - comment:homomint|comment:mint|figure legend:f3b f3d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2010/12/10 2014/10/16 rogid:NwJCQILox6pZfYrGno128U2xdpQ10090 rogid:kljigjgOmeCZOYMomkWxaVTWRoo10090 intact-crc:9B32CD22D1374B1E|rigid:AM6ZL/jpjCoqVZjGCTMpk4FD8D0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15357 uniprotkb:O60504 intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229 intact:EBI-741237|ensembl:ENSP00000240123|uniprotkb:Q5BJE4|uniprotkb:Q6NX54|uniprotkb:Q9UQE4|intact:EBI-1222937|uniprotkb:Q96FY4 psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym) psi-mi:vinex_human(display_long)|uniprotkb:SCAM1(gene name synonym)|uniprotkb:SH3-containing adapter molecule 1(gene name synonym)|uniprotkb:Sorbin and SH3 domain-containing protein 3(gene name synonym)|uniprotkb:SORBS3(gene name)|psi-mi:SORBS3(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Paternotte et al. (2005) pubmed:16302969|imex:IM-11616|mint:MINT-6671489|doi:10.1111/j.1742-4658.2005.04996 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7905084|mint:MINT-8078984|imex:IM-11616-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526|mint:MINT-8078987(identity) ensembl:ENSG00000120896(gene)|ensembl:ENST00000240123(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0017166"(vinculin binding)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR028510|interpro:IPR035607|interpro:IPR035608|interpro:IPR035609|interpro:IPR036028|mint:O60504|rcsb pdb:2CT3|rcsb pdb:2DLM|rcsb pdb:2NWM|rcsb pdb:2YUP|reactome:R-HSA-445355|refseq:NP_001018003.1|refseq:NP_005766.3|refseq:XP_005273428.1|refseq:XP_016868433.1|refseq:XP_016868434.1|refseq:XP_016868435.1|mint:MINT-8078986(identity) go:"GO:0032587"(ruffle membrane) - - figure legend:f4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/12/10 2014/10/16 rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606 rogid:Mq3VXduU/1gqfUwliO9sBBOb/Vc9606 intact-crc:045C3F7DC570DD5A|rigid:3n2Vgk4Uie0W0uA3hnhZQz7KQfk false his tag:?-?(MINT-8078994) ha tag:?-?(MINT-8078990) - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0422"(immunostaining)