#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q14432 uniprotkb:P29311 intact:EBI-7192066|ensembl:ENSP00000351957|uniprotkb:Q17RD1|uniprotkb:O60865|uniprotkb:Q13348|intact:MINT-3295914 intact:EBI-3661|uniprotkb:Q06854|uniprotkb:D3DM86|ensemblfungi:YER177W psi-mi:pde3a_human(display_long)|uniprotkb:PDE3A(gene name)|psi-mi:PDE3A(display_short)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase A(gene name synonym) psi-mi:bmh1_yeast(display_long)|uniprotkb:YER177W(locus name)|uniprotkb:BMH1(gene name)|psi-mi:BMH1(display_short) psi-mi:"MI:0047"(far western blotting) Pozuelo et al. (2005) pubmed:16153182|mint:MINT-8007193 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7814208|mint:MINT-8007200 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172572(gene)|ensembl:ENST00000359062(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0060282"(positive regulation of oocyte development)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|mint:Q14432|rcsb pdb:7KWE|rcsb pdb:7L27|rcsb pdb:7L28|rcsb pdb:7L29|rcsb pdb:7LRC|rcsb pdb:7LRD|reactome:R-HSA-418555|rcsb pdb:1LRC|refseq:NP_000912.3|dip:DIP-42197N|mint:MINT-8007204(identity)|uniprotkb:Q14432(original identifier) sgd:S000000979|refseq:NP_011104.3|dip:DIP-4313N|mint:P29311|ensemblfungi:YER177W(gene)|ensemblfungi:YER177W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030437"(ascospore formation)|go:"GO:0031578"(mitotic spindle orientation checkpoint signaling)|go:"GO:0034221"(fungal-type cell wall chitin biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070873"(regulation of glycogen metabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:5N6N|rcsb pdb:6QK8|mint:MINT-8007201(identity)|uniprotkb:P29311(original identifier) - function:"Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP)"|comment:mint|comment:homomint crc64:0A234167E313688B comment:domino|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/21 2014/10/16 rogid:saxVLeXHB0/wPyVoO7uR9+xiElY9606 rogid:RnX8tqsjlxM+7Mi+Thlhc1XrTy4559292 intact-crc:3F29CE2BE696A2CE|rigid:x6p+Bl0vpAZnX1jv2bjOavh2brQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)