#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q24210 uniprotkb:Q02280 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2940984|imex:IM-20524-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) - - - figure legend:Fig. 2A|delivery method:Q02280, Q24210 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis) - 2010/11/04 2014/10/16 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 intact-crc:CE479FFA7CEC578C|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02280 uniprotkb:Q24210 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2940989|imex:IM-20524-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 - - - figure legend:Fig. 2A|delivery method:Q02280, Q24210 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis) - 2010/11/04 2014/10/16 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 intact-crc:75BEEA5A35D87AD2|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q24210 uniprotkb:Q02280 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2941005|imex:IM-20524-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-larva)|taxid:7227(Drosophila melanogaster larva) - 2010/11/04 2014/10/16 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 intact-crc:CC693A7E932D7B49|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q24210 uniprotkb:Q02280 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:"MI:0096"(pull down) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2941016|imex:IM-20524-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) - - - figure legend:Fig. 5A|caution:The expression system for His-tagged proteins not given.|caution:Subsequent deletions suggested a shorter construct may bind but results were not consistent.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 intact-crc:81C3C7C751F8261C|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false glutathione s tranferase tag:?-? his tag:?-?|sufficient binding region:911-1034 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q02280 uniprotkb:Q24210 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:"MI:0096"(pull down) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2941029|imex:IM-20524-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 - - - figure legend:Fig. 5B|caution:The expression system for His-tagged proteins not given.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 intact-crc:ECD14374994BDA5C|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false his tag:?-?|sufficient binding region:911-1072 glutathione s tranferase tag:?-?|sufficient binding region:584-649(IPR001452)|sufficient binding region:710-868(IPR008144)|sufficient binding region:9-312(IPR000719) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q24210 uniprotkb:Q02280 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:"MI:0096"(pull down) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2941052|imex:IM-20524-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) - - - figure legend:Fig. 5C|caution:The expression system for His-tagged proteins not given.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 intact-crc:D9449F06665D07B3|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false glutathione s tranferase tag:?-?|sufficient binding region:710-868(IPR008144) his tag:?-?|sufficient binding region:911-1034 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q24210 uniprotkb:Q02280 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:"MI:0096"(pull down) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2941079|imex:IM-20524-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) - - - figure legend:Figs. 5C, 5D, 5F|caution:The expression system for His-tagged proteins not given.|comment:The interaction is resistant to increases in salt concentration, suggesting that binding is not solely mediated by electrostatic interactions.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 intact-crc:FF7A74451479413F|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false glutathione s tranferase tag:?-?|sufficient binding region:488-576(IPR001478) his tag:?-?|sufficient binding region:869-1107 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q24210 uniprotkb:Q02280 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:"MI:0096"(pull down) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2941095|imex:IM-20524-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) - - - figure legend:Fig. 5C|caution:The expression system for His-tagged proteins not given.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 intact-crc:7EA17D1542D36130|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false glutathione s tranferase tag:?-?|sufficient binding region:9-312(IPR000719) sufficient binding region:869-1107|his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P31007 uniprotkb:Q02280 intact:EBI-389374|uniprotkb:Q7KV38|uniprotkb:Q7KV39|uniprotkb:Q7KV40|uniprotkb:Q7YXH8|uniprotkb:Q8SY37|uniprotkb:Q8T0C6|uniprotkb:Q95TF5|uniprotkb:Q9VYZ4|uniprotkb:Q9VYZ5|uniprotkb:Q9VYZ6|uniprotkb:A4V4A8|uniprotkb:A4V4B0|uniprotkb:A8JUR9|uniprotkb:A8JUS0|uniprotkb:C7LAH6|intact:EBI-3430803|ensemblmetazoa:FBpp0089351 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 psi-mi:dlg1_drome(display_long)|uniprotkb:dlg1(gene name)|psi-mi:dlg1(display_short)|uniprotkb:"l(1)dlg1"(gene name synonym)|uniprotkb:CG1725(orf name) psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:"MI:0096"(pull down) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2941134|imex:IM-20524-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001245623.1|refseq:NP_001096955.1|refseq:NP_001096956.1|refseq:NP_001162719.1|refseq:NP_511120.2|refseq:NP_727518.1|refseq:NP_727519.1|refseq:NP_727520.1|refseq:NP_996402.1|refseq:NP_996403.1|refseq:NP_996404.1|refseq:NP_996405.1|refseq:NP_996406.1|refseq:NP_996407.1|flybase:FBgn0001624|refseq:NP_001259447.1|go:"GO:0007399"(nervous system development)|go:"GO:0007617"(mating behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008104"(protein localization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016335"(morphogenesis of larval imaginal disc epithelium)|go:"GO:0016336"(establishment or maintenance of polarity of larval imaginal disc epithelium)|go:"GO:0019991"(septate junction assembly)|go:"GO:0030054"(cell junction)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030714"(anterior/posterior axis specification, follicular epithelium)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042332"(gravitaxis)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045175"(basal protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046956"(positive phototaxis)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0060581"(cell fate commitment involved in pattern specification)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0061176"(type Ib terminal bouton)|go:"GO:0061689"(tricellular tight junction)|go:"GO:0071212"(subsynaptic reticulum)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|rcsb pdb:3TVT|rcsb pdb:4RP3|rcsb pdb:4RP4|rcsb pdb:4RP5|reactome:R-DME-438066|reactome:R-DME-451308|reactome:R-DME-6794361|reactome:R-DME-8849932|ensemblmetazoa:FBgn0001624(gene)|ensemblmetazoa:FBtr0073488(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005918"(septate junction)|go:"GO:0005920"(smooth septate junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007318"(pole plasm protein localization)|go:"GO:0007391"(dorsal closure)|dip:DIP-31531N refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) - - - figure legend:Figs. 5C, 5D|caution:The expression system for His-tagged proteins not given.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:NSQ2GlnRFSHOn1DErzrCGZaeSz47227 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 intact-crc:DC63B0318393A3ED|rigid:rjgEXoypAIFHJUQkFxsWPt/R90k false sufficient binding region:620..620-690..690(IPR001452) his tag:?-?|sufficient binding region:869-1107 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q02280 uniprotkb:Q24210 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:"MI:0096"(pull down) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2941187|imex:IM-20524-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 - - - figure legend:Fig. 6B|caution:The expression system for His-tagged proteins not given.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 intact-crc:C386E1B02A7F7D42|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false his tag:?-?|sufficient binding region:869-1107|mutation decreasing interaction:1037-1037|mutation decreasing interaction:1040-1040 glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q24210 uniprotkb:Q02280 intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559 intact:EBI-85304|uniprotkb:Q9VXZ6|ensemblmetazoa:FBpp0073772 psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym) psi-mi:kcnae_drome(display_long)|uniprotkb:eag(gene name)|psi-mi:eag(display_short)|uniprotkb:Ether-a-go-go protein(gene name synonym)|uniprotkb:CG10952(orf name) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Marble et al. (2005) pubmed:15901771|imex:IM-20524 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2941170|imex:IM-20524-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361 refseq:NP_511158.2|flybase:FBgn0000535|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000700(PAS-associated, C-terminal)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR003949(Potassium channel, voltage-dependent, EAG)|interpro:IPR005821(Ion transport)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR035965|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-1296072|go:"GO:1903818"(positive regulation of voltage-gated potassium channel activity)|interpro:IPR000014(PAS)|ensemblmetazoa:FBgn0000535(gene)|ensemblmetazoa:FBtr0073955(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007619"(courtship behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0042066"(perineurial glial growth)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048150"(behavioral response to ether)|go:"GO:0071805"(potassium ion transmembrane transport) - - - figure legend:Figs. 5C, 5D|caution:The expression system for His-tagged proteins not given.|comment:Full-length caki bound eag with a KD of 1-2nM|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227 rogid:NuiW+3la4tADV2Y5NCK6/F1Wlxg7227 intact-crc:DCDCC8DD61705D84|rigid:5MLzep/pp8iL7BZE945yk5x66PQ false glutathione s tranferase tag:?-?|sufficient binding region:488-576(IPR001478) his tag:?-?|sufficient binding region:869-1107 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)