#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43184-2	uniprotkb:O95633	intact:EBI-2625865|ensembl:ENSP00000357665	intact:EBI-2625790|uniprotkb:A8K7E3|ensembl:ENSP00000166139	psi-mi:o43184-2(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)|uniprotkb:12S(isoform synonym)	psi-mi:fstl3_human(display_long)|uniprotkb:FSTL3(gene name)|psi-mi:FSTL3(display_short)|uniprotkb:FLRG(gene name synonym)|uniprotkb:Follistatin-like protein 3(gene name synonym)|uniprotkb:Follistatin-related gene protein(gene name synonym)|uniprotkb:UNQ674/PRO1308(orf name)	psi-mi:"MI:0018"(two hybrid)	Bartholin et al. (2005)	pubmed:15574124|imex:IM-20450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2625877|imex:IM-20450-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2625825(isoform-parent)|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368676(transcript)	refseq:NP_005851.1|ensembl:ENSG00000070404(gene)|ensembl:ENST00000166139(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001822"(kidney development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0090101"(negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR036058|interpro:IPR036773|rcsb pdb:2KCX|rcsb pdb:3B4V|rcsb pdb:3SEK|reactome:R-HSA-2473224|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017878	-	-	-	figure legend:Fig. 1. A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/03/29	2014/10/16	rogid:J2hM7SCortnj7/OkSXsn+VL1iYY9606	rogid:9urDp5vXg3dnLXR1Ar8wL2tpHwM9606	intact-crc:346116E08AED4936|rigid:Xl8mHCBsWWrC8VlHOlx1hPF8Sww	false	-	binding-associated region:27-263	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43184-2	uniprotkb:O95633	intact:EBI-2625865|ensembl:ENSP00000357665	intact:EBI-2625790|uniprotkb:A8K7E3|ensembl:ENSP00000166139	psi-mi:o43184-2(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)|uniprotkb:12S(isoform synonym)	psi-mi:fstl3_human(display_long)|uniprotkb:FSTL3(gene name)|psi-mi:FSTL3(display_short)|uniprotkb:FLRG(gene name synonym)|uniprotkb:Follistatin-like protein 3(gene name synonym)|uniprotkb:Follistatin-related gene protein(gene name synonym)|uniprotkb:UNQ674/PRO1308(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bartholin et al. (2005)	pubmed:15574124|imex:IM-20450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2625898|imex:IM-20450-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2625825(isoform-parent)|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368676(transcript)	refseq:NP_005851.1|ensembl:ENSG00000070404(gene)|ensembl:ENST00000166139(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001822"(kidney development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0090101"(negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR036058|interpro:IPR036773|rcsb pdb:2KCX|rcsb pdb:3B4V|rcsb pdb:3SEK|reactome:R-HSA-2473224|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017878	-	-	-	figure legend:Fig. 2|delivery method:O43184-2;O95633 transfection|comment:The truncated ADAM12 contains the disintegrin domain, the cysteine-rich domain and the C-terminus and lacking the pro- and metalloprotease domains.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2010/03/29	2014/10/16	rogid:J2hM7SCortnj7/OkSXsn+VL1iYY9606	rogid:9urDp5vXg3dnLXR1Ar8wL2tpHwM9606	intact-crc:5ED24438E85B2EA0|rigid:Xl8mHCBsWWrC8VlHOlx1hPF8Sww	false	his tag:c-c|binding-associated region:416..416-738..738|35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95633	uniprotkb:O43184-2	intact:EBI-2625790|uniprotkb:A8K7E3|ensembl:ENSP00000166139	intact:EBI-2625865|ensembl:ENSP00000357665	psi-mi:fstl3_human(display_long)|uniprotkb:FSTL3(gene name)|psi-mi:FSTL3(display_short)|uniprotkb:FLRG(gene name synonym)|uniprotkb:Follistatin-like protein 3(gene name synonym)|uniprotkb:Follistatin-related gene protein(gene name synonym)|uniprotkb:UNQ674/PRO1308(orf name)	psi-mi:o43184-2(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)|uniprotkb:12S(isoform synonym)	psi-mi:"MI:0047"(far western blotting)	Bartholin et al. (2005)	pubmed:15574124|imex:IM-20450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2625920|imex:IM-20450-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005851.1|ensembl:ENSG00000070404(gene)|ensembl:ENST00000166139(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001822"(kidney development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0090101"(negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR036058|interpro:IPR036773|rcsb pdb:2KCX|rcsb pdb:3B4V|rcsb pdb:3SEK|reactome:R-HSA-2473224|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017878	intact:EBI-2625825(isoform-parent)|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368676(transcript)	-	-	-	figure legend:Fig. 3|isoform-comment:the cysteine-rich region is also present in ADAM12-L isoform|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/29	2014/10/16	rogid:9urDp5vXg3dnLXR1Ar8wL2tpHwM9606	rogid:J2hM7SCortnj7/OkSXsn+VL1iYY9606	intact-crc:EB07A1A1CA983A6D|rigid:Xl8mHCBsWWrC8VlHOlx1hPF8Sww	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:512..512-704..704(IPR006586)	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O43184-2	uniprotkb:P19883	intact:EBI-2625865|ensembl:ENSP00000357665	intact:EBI-1571188|uniprotkb:Q9BTH0|ensembl:ENSP00000256759|uniprotkb:B5BU94	psi-mi:o43184-2(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)|uniprotkb:12S(isoform synonym)	psi-mi:fst_human(display_long)|uniprotkb:Activin-binding protein(gene name synonym)|uniprotkb:FST(gene name)|psi-mi:FST(display_short)	psi-mi:"MI:0047"(far western blotting)	Bartholin et al. (2005)	pubmed:15574124|imex:IM-20450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2625934|imex:IM-20450-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2625825(isoform-parent)|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368676(transcript)	ensembl:ENSG00000134363(gene)|ensembl:ENST00000256759(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0007389"(pattern specification process)|go:"GO:0008585"(female gonad development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0038102"(activin receptor antagonist activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048185"(activin binding)|go:"GO:0051798"(positive regulation of hair follicle development)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR017878|interpro:IPR036058|interpro:IPR036773|rcsb pdb:2P6A|rcsb pdb:3HH2|rcsb pdb:5JHW|reactome:R-HSA-2473224|rcsb pdb:2B0U|refseq:NP_006341.1|refseq:NP_037541.1	-	-	-	figure legend:Fig. 3|isoform-comment:the cysteine-rich region is also present in ADAM12-L isoform|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/29	2014/10/16	rogid:J2hM7SCortnj7/OkSXsn+VL1iYY9606	rogid:+g4SG1U00WzrjZWzOXPDoMP5c/I9606	intact-crc:30BFDBE38609369D|rigid:tq0jrwm/PeOfcQuOZCkjvgbvoTo	false	glutathione s tranferase tag:?-?|sufficient binding region:512..512-704..704(IPR006586)	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P19883	uniprotkb:P78325	intact:EBI-1571188|uniprotkb:Q9BTH0|ensembl:ENSP00000256759|uniprotkb:B5BU94	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:fst_human(display_long)|uniprotkb:Activin-binding protein(gene name synonym)|uniprotkb:FST(gene name)|psi-mi:FST(display_short)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Bartholin et al. (2005)	pubmed:15574124|imex:IM-20450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2625975|imex:IM-20450-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134363(gene)|ensembl:ENST00000256759(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007276"(gamete generation)|go:"GO:0007389"(pattern specification process)|go:"GO:0008585"(female gonad development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0038102"(activin receptor antagonist activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048185"(activin binding)|go:"GO:0051798"(positive regulation of hair follicle development)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR017878|interpro:IPR036058|interpro:IPR036773|rcsb pdb:2P6A|rcsb pdb:3HH2|rcsb pdb:5JHW|reactome:R-HSA-2473224|rcsb pdb:2B0U|refseq:NP_006341.1|refseq:NP_037541.1	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Fig. 3|comment:The cDNA construct the authors used coded for ADAM8 with the amino acid at the position 657 which is a Phenylalanine instead of a leucine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/29	2014/10/16	rogid:+g4SG1U00WzrjZWzOXPDoMP5c/I9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	intact-crc:35B3EE313E4A1DEB|rigid:tTezNKXJN8+sWh41xWLkLFCngD8	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|binding-associated region:470..470-612..612(IPR006586)	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P78325	uniprotkb:O95633	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	intact:EBI-2625790|uniprotkb:A8K7E3|ensembl:ENSP00000166139	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:fstl3_human(display_long)|uniprotkb:FSTL3(gene name)|psi-mi:FSTL3(display_short)|uniprotkb:FLRG(gene name synonym)|uniprotkb:Follistatin-like protein 3(gene name synonym)|uniprotkb:Follistatin-related gene protein(gene name synonym)|uniprotkb:UNQ674/PRO1308(orf name)	psi-mi:"MI:0047"(far western blotting)	Bartholin et al. (2005)	pubmed:15574124|imex:IM-20450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2625987|imex:IM-20450-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	refseq:NP_005851.1|ensembl:ENSG00000070404(gene)|ensembl:ENST00000166139(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001822"(kidney development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0090101"(negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR036058|interpro:IPR036773|rcsb pdb:2KCX|rcsb pdb:3B4V|rcsb pdb:3SEK|reactome:R-HSA-2473224|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017878	-	-	-	figure legend:Fig. 3|comment:The cDNA construct the authors used coded for ADAM8 with the amino acid at the position 657 which is a Phenylalanine instead of a leucine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/29	2014/10/16	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rogid:9urDp5vXg3dnLXR1Ar8wL2tpHwM9606	intact-crc:59FF14099ECD9EA3|rigid:9VioqHRPSTzWdmqGG83CEcXAVaw	false	glutathione s tranferase tag:?-?|binding-associated region:470..470-612..612(IPR006586)	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O95633	uniprotkb:O43184-2	intact:EBI-2625790|uniprotkb:A8K7E3|ensembl:ENSP00000166139	intact:EBI-2625865|ensembl:ENSP00000357665	psi-mi:fstl3_human(display_long)|uniprotkb:FSTL3(gene name)|psi-mi:FSTL3(display_short)|uniprotkb:FLRG(gene name synonym)|uniprotkb:Follistatin-like protein 3(gene name synonym)|uniprotkb:Follistatin-related gene protein(gene name synonym)|uniprotkb:UNQ674/PRO1308(orf name)	psi-mi:o43184-2(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)|uniprotkb:12S(isoform synonym)	psi-mi:"MI:0018"(two hybrid)	Bartholin et al. (2005)	pubmed:15574124|imex:IM-20450	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2638288|imex:IM-20450-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005851.1|ensembl:ENSG00000070404(gene)|ensembl:ENST00000166139(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001822"(kidney development)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0090101"(negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR015369(Follistatin)|interpro:IPR036058|interpro:IPR036773|rcsb pdb:2KCX|rcsb pdb:3B4V|rcsb pdb:3SEK|reactome:R-HSA-2473224|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017878	intact:EBI-2625825(isoform-parent)|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368676(transcript)	-	-	-	figure legend:Fig. 1. B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/03/29	2014/10/16	rogid:9urDp5vXg3dnLXR1Ar8wL2tpHwM9606	rogid:J2hM7SCortnj7/OkSXsn+VL1iYY9606	intact-crc:7632BE347A2C6566|rigid:Xl8mHCBsWWrC8VlHOlx1hPF8Sww	false	binding-associated region:27-263	necessary binding region:546-738	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)