#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62161	uniprotkb:P23711	intact:EBI-397530|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q61379|uniprotkb:Q61380|dip:DIP-29528N|refseq:NP_059022|uniprotkb:P0DP30	intact:EBI-2910092|ensembl:ENSRNOP00000005031|ensembl:ENSRNOP00000075102	psi-mi:calm_rat(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:CaMII(gene name synonym)	psi-mi:hmox2_rat(display_long)|uniprotkb:Hmox2(gene name)|psi-mi:Hmox2(display_short)	psi-mi:"MI:0018"(two hybrid)	Boehning et al. (2004)	pubmed:15175337|imex:IM-20510	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2910111|imex:IM-20510-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4G27|rcsb pdb:4G28|go:"GO:0030426"(growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:4I2Y|rcsb pdb:4IL1|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|rcsb pdb:4RJD|go:"GO:0000922"(spindle pole)|go:"GO:0005246"(calcium channel regulator activity)|rgd:2257|rgd:2258|rgd:2259|refseq:NP_036650.1|refseq:NP_059022.1|refseq:NP_114175.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:1G4Y|rcsb pdb:1NIW|rcsb pdb:1QX5|rcsb pdb:1QX7|rcsb pdb:2HQW|rcsb pdb:2PQ3|rcsb pdb:3B32|rcsb pdb:3BXK|rcsb pdb:3BXL|rcsb pdb:3CLN|rcsb pdb:3EK4|rcsb pdb:3EK7|rcsb pdb:3EK8|rcsb pdb:3EKH|rcsb pdb:3EKJ|rcsb pdb:3EVR|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3IFK|rcsb pdb:3SG2|rcsb pdb:3SG3|rcsb pdb:3SG4|rcsb pdb:3SG5|rcsb pdb:3SG6|rcsb pdb:3SG7|rcsb pdb:3SJQ|rcsb pdb:4QNH|go:"GO:0005509"(calcium ion binding)|reactome:R-RNO-2672351|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-936837|rcsb pdb:4OY4|go:"GO:0005829"(cytosol)|rcsb pdb:2YGG|go:"GO:0005886"(plasma membrane)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034704"(calcium channel complex)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|reactome:R-RNO-8876725|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|rcsb pdb:4EHQ|rcsb pdb:4J9Y|rcsb pdb:4J9Z|reactome:R-RNO-163615|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048306"(calcium-dependent protein binding)|rcsb pdb:2MGU|ensembl:ENSRNOT00000022603|ensembl:ENSRNOT00000064679|rcsb pdb:3WLC|rcsb pdb:3WLD|reactome:R-RNO-111932|reactome:R-RNO-111933|reactome:R-RNO-111957|reactome:R-RNO-114608|reactome:R-RNO-1474151|reactome:R-RNO-1855204|reactome:R-RNO-203615|reactome:R-RNO-2514859|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-442717|reactome:R-RNO-442729|reactome:R-RNO-442745|reactome:R-RNO-442982|reactome:R-RNO-445355|reactome:R-RNO-451308|reactome:R-RNO-5218920|reactome:R-RNO-5607763|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5673001|reactome:R-RNO-70221|ensembl:ENSRNOG00000004060|ensembl:ENSRNOG00000016770|ensembl:ENSRNOP00000022603|ensembl:ENSRNOP00000063822|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)	ensembl:ENSRNOG00000003773(gene)|ensembl:ENSRNOT00000005031(transcript)|ensembl:ENSRNOT00000077164(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004392"("heme oxygenase (decyclizing) activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006788"(heme oxidation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0020037"(heme binding)|go:"GO:0042167"(heme catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR002051(Haem oxygenase)|interpro:IPR016084(Haem oxygenase-like, multi-helical)|interpro:IPR018207|reactome:R-RNO-189483|reactome:R-RNO-6798695|reactome:R-RNO-8980692|reactome:R-RNO-917937|reactome:R-RNO-9707564|interpro:IPR016053(Haem oxygenase-like)|refseq:NP_001264002.1|rgd:67402|refseq:NP_077363.1|refseq:XP_006245889.1	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/08/24	2014/10/16	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10116	rogid:VYztrLKtIPoFppGT9BoZtDMnmPI10116	intact-crc:67E017027E0827E9|rigid:ypGeY9k4ya3V2bpwaFNDxs/ag8U	false	-	sufficient binding region:1-292	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62157	uniprotkb:P23711	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-2910092|ensembl:ENSRNOP00000005031|ensembl:ENSRNOP00000075102	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:hmox2_rat(display_long)|uniprotkb:Hmox2(gene name)|psi-mi:Hmox2(display_short)	psi-mi:"MI:0096"(pull down)	Boehning et al. (2004)	pubmed:15175337|imex:IM-20510	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2910124|imex:IM-20510-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSRNOG00000003773(gene)|ensembl:ENSRNOT00000005031(transcript)|ensembl:ENSRNOT00000077164(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004392"("heme oxygenase (decyclizing) activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006788"(heme oxidation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0020037"(heme binding)|go:"GO:0042167"(heme catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR002051(Haem oxygenase)|interpro:IPR016084(Haem oxygenase-like, multi-helical)|interpro:IPR018207|reactome:R-RNO-189483|reactome:R-RNO-6798695|reactome:R-RNO-8980692|reactome:R-RNO-917937|reactome:R-RNO-9707564|interpro:IPR016053(Haem oxygenase-like)|refseq:NP_001264002.1|rgd:67402|refseq:NP_077363.1|refseq:XP_006245889.1	-	-	-	figure legend:Figs. 1b, 1d|agonist:HO2 binds to calmodulin only in presence of Ca2+|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/08/24	2014/10/16	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:VYztrLKtIPoFppGT9BoZtDMnmPI10116	intact-crc:3C6B75AF4B1B0009|rigid:I61eDXSbJwHUcg8qn98Z91E/vrY	false	-	glutathione s tranferase tag:?-?|sufficient binding region:55-90	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62157	uniprotkb:P23711	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-2910092|ensembl:ENSRNOP00000005031|ensembl:ENSRNOP00000075102	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:hmox2_rat(display_long)|uniprotkb:Hmox2(gene name)|psi-mi:Hmox2(display_short)	psi-mi:"MI:0096"(pull down)	Boehning et al. (2004)	pubmed:15175337|imex:IM-20510	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2910145|imex:IM-20510-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSRNOG00000003773(gene)|ensembl:ENSRNOT00000005031(transcript)|ensembl:ENSRNOT00000077164(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004392"("heme oxygenase (decyclizing) activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006788"(heme oxidation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0020037"(heme binding)|go:"GO:0042167"(heme catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR002051(Haem oxygenase)|interpro:IPR016084(Haem oxygenase-like, multi-helical)|interpro:IPR018207|reactome:R-RNO-189483|reactome:R-RNO-6798695|reactome:R-RNO-8980692|reactome:R-RNO-917937|reactome:R-RNO-9707564|interpro:IPR016053(Haem oxygenase-like)|refseq:NP_001264002.1|rgd:67402|refseq:NP_077363.1|refseq:XP_006245889.1	-	-	-	figure legend:Fig. 1c|comment:Binding increased in presence of Ca2+|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/08/24	2014/10/16	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:VYztrLKtIPoFppGT9BoZtDMnmPI10116	intact-crc:3565C4321457827A|rigid:I61eDXSbJwHUcg8qn98Z91E/vrY	false	-	glutathione s tranferase tag:?-?|mutation increasing interaction:57-57|mutation decreasing interaction:66-66|mutation decreasing interaction:66-66	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62161	uniprotkb:P23711	intact:EBI-397530|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q61379|uniprotkb:Q61380|dip:DIP-29528N|refseq:NP_059022|uniprotkb:P0DP30	intact:EBI-2910092|ensembl:ENSRNOP00000005031|ensembl:ENSRNOP00000075102	psi-mi:calm_rat(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:CaMII(gene name synonym)	psi-mi:hmox2_rat(display_long)|uniprotkb:Hmox2(gene name)|psi-mi:Hmox2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Boehning et al. (2004)	pubmed:15175337|imex:IM-20510	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2910180|imex:IM-20510-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4G27|rcsb pdb:4G28|go:"GO:0030426"(growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:4I2Y|rcsb pdb:4IL1|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|rcsb pdb:4RJD|go:"GO:0000922"(spindle pole)|go:"GO:0005246"(calcium channel regulator activity)|rgd:2257|rgd:2258|rgd:2259|refseq:NP_036650.1|refseq:NP_059022.1|refseq:NP_114175.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:1G4Y|rcsb pdb:1NIW|rcsb pdb:1QX5|rcsb pdb:1QX7|rcsb pdb:2HQW|rcsb pdb:2PQ3|rcsb pdb:3B32|rcsb pdb:3BXK|rcsb pdb:3BXL|rcsb pdb:3CLN|rcsb pdb:3EK4|rcsb pdb:3EK7|rcsb pdb:3EK8|rcsb pdb:3EKH|rcsb pdb:3EKJ|rcsb pdb:3EVR|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3IFK|rcsb pdb:3SG2|rcsb pdb:3SG3|rcsb pdb:3SG4|rcsb pdb:3SG5|rcsb pdb:3SG6|rcsb pdb:3SG7|rcsb pdb:3SJQ|rcsb pdb:4QNH|go:"GO:0005509"(calcium ion binding)|reactome:R-RNO-2672351|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-936837|rcsb pdb:4OY4|go:"GO:0005829"(cytosol)|rcsb pdb:2YGG|go:"GO:0005886"(plasma membrane)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034704"(calcium channel complex)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|reactome:R-RNO-8876725|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|rcsb pdb:4EHQ|rcsb pdb:4J9Y|rcsb pdb:4J9Z|reactome:R-RNO-163615|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048306"(calcium-dependent protein binding)|rcsb pdb:2MGU|ensembl:ENSRNOT00000022603|ensembl:ENSRNOT00000064679|rcsb pdb:3WLC|rcsb pdb:3WLD|reactome:R-RNO-111932|reactome:R-RNO-111933|reactome:R-RNO-111957|reactome:R-RNO-114608|reactome:R-RNO-1474151|reactome:R-RNO-1855204|reactome:R-RNO-203615|reactome:R-RNO-2514859|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-442717|reactome:R-RNO-442729|reactome:R-RNO-442745|reactome:R-RNO-442982|reactome:R-RNO-445355|reactome:R-RNO-451308|reactome:R-RNO-5218920|reactome:R-RNO-5607763|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5673001|reactome:R-RNO-70221|ensembl:ENSRNOG00000004060|ensembl:ENSRNOG00000016770|ensembl:ENSRNOP00000022603|ensembl:ENSRNOP00000063822|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)	ensembl:ENSRNOG00000003773(gene)|ensembl:ENSRNOT00000005031(transcript)|ensembl:ENSRNOT00000077164(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004392"("heme oxygenase (decyclizing) activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006788"(heme oxidation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0020037"(heme binding)|go:"GO:0042167"(heme catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR002051(Haem oxygenase)|interpro:IPR016084(Haem oxygenase-like, multi-helical)|interpro:IPR018207|reactome:R-RNO-189483|reactome:R-RNO-6798695|reactome:R-RNO-8980692|reactome:R-RNO-917937|reactome:R-RNO-9707564|interpro:IPR016053(Haem oxygenase-like)|refseq:NP_001264002.1|rgd:67402|refseq:NP_077363.1|refseq:XP_006245889.1	-	-	-	figure legend:Fig. 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain-cortex)|taxid:10116(Rattus norvegicus brain cortex)	-	2010/08/24	2014/10/16	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10116	rogid:VYztrLKtIPoFppGT9BoZtDMnmPI10116	intact-crc:77783CB13093E19A|rigid:ypGeY9k4ya3V2bpwaFNDxs/ag8U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:24493"	uniprotkb:P62157	intact:EBI-2432259	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	psi-mi:hemin(display_short)|psi-mi:"CHEBI:24493"(display_long)	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Boehning et al. (2004)	pubmed:15175337|imex:IM-20510	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2910412|imex:IM-20510-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	go:"GO:0006788"(heme oxidation)|go:"GO:0004392"("heme oxygenase (decyclizing) activity")	-	-	figure legend:Fig. 2a-c|agonist:Calcium, Calmodulin|kinetics:HO2 activity increased by 3-fold in presence of calmodulin with EC50=287nM calcium.  EC50 for activation by calmodulin was 2nM.|inhibition:Calmidazolium chloride inhibits HO2 activity with an IC50 of 8uM with 1uM Ca2+ and 100nM calmodulin.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/08/24	2014/10/16	-	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	intact-crc:5B45F002099F3EBF	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62157	uniprotkb:P23711	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-2910092|ensembl:ENSRNOP00000005031|ensembl:ENSRNOP00000075102	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:hmox2_rat(display_long)|uniprotkb:Hmox2(gene name)|psi-mi:Hmox2(display_short)	psi-mi:"MI:0415"(enzymatic study)	Boehning et al. (2004)	pubmed:15175337|imex:IM-20510	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2910412|imex:IM-20510-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSRNOG00000003773(gene)|ensembl:ENSRNOT00000005031(transcript)|ensembl:ENSRNOT00000077164(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004392"("heme oxygenase (decyclizing) activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006788"(heme oxidation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0020037"(heme binding)|go:"GO:0042167"(heme catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR002051(Haem oxygenase)|interpro:IPR016084(Haem oxygenase-like, multi-helical)|interpro:IPR018207|reactome:R-RNO-189483|reactome:R-RNO-6798695|reactome:R-RNO-8980692|reactome:R-RNO-917937|reactome:R-RNO-9707564|interpro:IPR016053(Haem oxygenase-like)|refseq:NP_001264002.1|rgd:67402|refseq:NP_077363.1|refseq:XP_006245889.1	go:"GO:0006788"(heme oxidation)|go:"GO:0004392"("heme oxygenase (decyclizing) activity")	-	-	figure legend:Fig. 2a-c|agonist:Calcium, Calmodulin|kinetics:HO2 activity increased by 3-fold in presence of calmodulin with EC50=287nM calcium.  EC50 for activation by calmodulin was 2nM.|inhibition:Calmidazolium chloride inhibits HO2 activity with an IC50 of 8uM with 1uM Ca2+ and 100nM calmodulin.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/08/24	2014/10/16	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:VYztrLKtIPoFppGT9BoZtDMnmPI10116	intact-crc:5B45F002099F3EBF	false	-	glutathione s tranferase tag:?-?|mutation disrupting interaction:66-66	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)