#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P41143	uniprotkb:Q5JY77	intact:EBI-2624456|uniprotkb:B5B0B8|ensembl:ENSP00000234961	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	psi-mi:oprd_human(display_long)|uniprotkb:OPRD1(gene name)|psi-mi:OPRD1(display_short)|uniprotkb:OPRD(gene name synonym)	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615676|imex:IM-20433-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000902.3|ensembl:ENSG00000116329(gene)|ensembl:ENST00000234961(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032590"(dendrite membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038046"(G protein-coupled enkephalin receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097444"(spine apparatus)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000321(Delta opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P41143|rcsb pdb:1OZC|rcsb pdb:2IQM|rcsb pdb:4N6H|rcsb pdb:4RWA|rcsb pdb:4RWD|rcsb pdb:6PT2|rcsb pdb:6PT3|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-6785807|go:"GO:0071456"(cellular response to hypoxia)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	-	-	-	caution:discrepancy between information in the paper for bait sequence and the sequence in the database|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/03/15	2014/10/16	rogid:47Egb9vEVBuRADGdyZqCRPHk5gI9606	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	intact-crc:5BBC9D43D33281EC|rigid:s2XIBLJSE56sMEYWWPpq7g+O1mg	false	sufficient binding region:326..362-372	sufficient binding region:924-1395	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P41143	uniprotkb:Q5JY77	intact:EBI-2624456|uniprotkb:B5B0B8|ensembl:ENSP00000234961	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	psi-mi:oprd_human(display_long)|uniprotkb:OPRD1(gene name)|psi-mi:OPRD1(display_short)|uniprotkb:OPRD(gene name synonym)	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615696|imex:IM-20433-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000902.3|ensembl:ENSG00000116329(gene)|ensembl:ENST00000234961(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032590"(dendrite membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038046"(G protein-coupled enkephalin receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097444"(spine apparatus)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000321(Delta opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P41143|rcsb pdb:1OZC|rcsb pdb:2IQM|rcsb pdb:4N6H|rcsb pdb:4RWA|rcsb pdb:4RWD|rcsb pdb:6PT2|rcsb pdb:6PT3|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-6785807|go:"GO:0071456"(cellular response to hypoxia)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	-	-	-	figure legend:Fig 1C and Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:47Egb9vEVBuRADGdyZqCRPHk5gI9606	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	intact-crc:A0F74C7824952AC9|rigid:s2XIBLJSE56sMEYWWPpq7g+O1mg	false	mutation decreasing interaction:325-326|glutathione s tranferase tag:?-?|sufficient binding region:314-372	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P41145	uniprotkb:Q5JY77	intact:EBI-925028|uniprotkb:Q499G4|uniprotkb:E5RHC9|ensembl:ENSP00000265572|ensembl:ENSP00000429706	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	psi-mi:oprk_human(display_long)|uniprotkb:OPRK1(gene name)|psi-mi:OPRK1(display_short)|uniprotkb:OPRK(gene name synonym)	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615711|imex:IM-20433-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000903.2|refseq:NP_001305426.1|refseq:NP_001269833.1|ensembl:ENSG00000082556(gene)|ensembl:ENST00000265572(transcript)|ensembl:ENST00000520287(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0033685"(negative regulation of luteinizing hormone secretion)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038048"(dynorphin receptor activity)|go:"GO:0040017"(positive regulation of locomotion)|go:"GO:0042277"(peptide binding)|go:"GO:0042711"(maternal behavior)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044849"(estrous cycle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046877"(regulation of saliva secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050951"(sensory perception of temperature stimulus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:1990708"(conditioned place preference)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000452(Kappa opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2A0D|rcsb pdb:2IQN|rcsb pdb:4DJH|rcsb pdb:6B73|rcsb pdb:6VI4|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-9022699	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	-	-	-	figure legend:Fig 1C|comment:Further analysis of OPRK1 suggested residues 327-340 may be required to bind but this was performed using a murine protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:UJUQfTpWND3otpIeautU4Nx0Ru49606	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	intact-crc:A5D7651EF4E0F5AB|rigid:Y/P0Ob6jmW04GtO7oj1d/nvowRc	false	glutathione s tranferase tag:?-?|sufficient binding region:326-380	35s radiolabel:?-?|sufficient binding region:924-1395	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5JY77	uniprotkb:P35372	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615758|imex:IM-20433-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	-	-	-	figure legend:Fig 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	intact-crc:139C5186DFF3B930|rigid:ls67wFALiPOA1P5CA9O1rUahSm4	false	35s radiolabel:?-?|sufficient binding region:924-1395	glutathione s tranferase tag:?-?|sufficient binding region:334-400	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11229	uniprotkb:Q5JY77	intact:EBI-2624759|ensembl:ENSP00000306490|uniprotkb:Q96RH1	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	psi-mi:acm1_human(display_long)|uniprotkb:CHRM1(gene name)|psi-mi:CHRM1(display_short)	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615794|imex:IM-20433-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168539(gene)|ensembl:ENST00000306960(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007399"(nervous system development)|refseq:XP_011543044.1|refseq:NP_000729.2|go:"GO:0016020"(membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0046541"(saliva secretion)|go:"GO:0050890"(cognition)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002228(Muscarinic acetylcholine receptor M1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5CXV|rcsb pdb:6OIJ|rcsb pdb:6WJC|reactome:R-HSA-390648|reactome:R-HSA-416476|interpro:IPR000995(Muscarinic acetylcholine receptor)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	-	-	-	figure legend:Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:h4KvtChdArk35BJmdzgVwGfbc4A9606	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	intact-crc:3EE4B997F3D352D3|rigid:3aIuH5zSpaXtZS1JJlIhbF4dMJg	false	glutathione s tranferase tag:?-?|sufficient binding region:414-460	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5JY77	uniprotkb:P41146	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	intact:EBI-2624699|uniprotkb:Q8TD34|uniprotkb:Q8WYH9|uniprotkb:Q9H4K4|ensembl:ENSP00000336764|ensembl:ENSP00000336843|ensembl:ENSP00000347848	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:oprx_human(display_long)|uniprotkb:OPRL1(gene name)|psi-mi:OPRL1(display_short)|uniprotkb:OOR(gene name synonym)|uniprotkb:ORL1(gene name synonym)|uniprotkb:Orphanin FQ receptor(gene name synonym)|uniprotkb:Kappa-type 3 opioid receptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615769|imex:IM-20433-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	refseq:NP_000904.1|refseq:NP_001186948.1|refseq:NP_872588.1|refseq:XP_016883343.1|refseq:XP_016883344.1|ensembl:ENSG00000125510(gene)|ensembl:ENST00000336866(transcript)|ensembl:ENST00000349451(transcript)|ensembl:ENST00000355631(transcript)|go:"GO:0001626"(nociceptin receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060454"(positive regulation of gastric acid secretion)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1990708"(conditioned place preference)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR001420(X opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P41146|rcsb pdb:4EA3|rcsb pdb:5DHG|rcsb pdb:5DHH|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001305782.1|refseq:NP_001305783.1|refseq:NP_001305784.1	-	-	-	figure legend:Fig 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	rogid:XB+gV8yHArDnVcaYZADiPZRgncE9606	intact-crc:D47F48E68E1A765D|rigid:kaDzkmSpqwZ2Vfyyxp7Eiy9FuuA	false	sufficient binding region:924-1395|35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:315-370	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5JY77	uniprotkb:P08172	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	intact:EBI-2624832|uniprotkb:Q4VBK6|uniprotkb:Q9P1X9|ensembl:ENSP00000319984|ensembl:ENSP00000384401|ensembl:ENSP00000399745|ensembl:ENSP00000415386|ensembl:ENSP00000505686	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:acm2_human(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615808|imex:IM-20433-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	refseq:XP_011514071.1|refseq:NP_000730.1|refseq:NP_001006627.1|refseq:NP_001006628.1|refseq:NP_001006629.1|refseq:NP_001006630.1|refseq:NP_001006631.1|refseq:NP_001006632.1|refseq:NP_001006633.1|ensembl:ENSG00000181072(gene)|ensembl:ENST00000320658(transcript)|ensembl:ENST00000401861(transcript)|ensembl:ENST00000445907(transcript)|ensembl:ENST00000453373(transcript)|ensembl:ENST00000680005(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LUB|rcsb pdb:3UON|rcsb pdb:4MQS|rcsb pdb:4MQT|rcsb pdb:5YC8|rcsb pdb:5ZK3|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|rcsb pdb:5ZKB|rcsb pdb:5ZKC|rcsb pdb:6OIK|rcsb pdb:6U1N|reactome:R-HSA-390648|reactome:R-HSA-418594|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:5ZK8|dip:DIP-56282N	-	-	-	figure legend:Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	rogid:Rg7s3/iAh4+DTvkasK8G/BWc+yM9606	intact-crc:9F481F3D83152666|rigid:npaLeEOOMlOV4JWkv35WuMkd+Fc	false	35s radiolabel:?-?	sufficient binding region:436-466|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P34969	uniprotkb:Q5JY77	intact:EBI-2625020|uniprotkb:B5BUP6|uniprotkb:P78336|uniprotkb:P78372|uniprotkb:P78516|uniprotkb:Q5VX01|uniprotkb:Q5VX02|ensembl:ENSP00000337949|uniprotkb:Q5VX03	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	psi-mi:5ht7r_human(display_long)|uniprotkb:HTR7(gene name)|psi-mi:HTR7(display_short)|uniprotkb:5-HT-X(gene name synonym)|uniprotkb:Serotonin receptor 7(gene name synonym)	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615842|imex:IM-20433-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000863.1|refseq:NP_062873.1|refseq:NP_062874.1|ensembl:ENSG00000148680(gene)|ensembl:ENST00000336152(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008015"(blood circulation)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042310"(vasoconstriction)|go:"GO:0045202"(synapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001069(5-Hydroxytryptamine 7 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821|reactome:R-HSA-9706019	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	-	-	-	figure legend:Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:NoHrTf52SNxtQ9a9C5SaPy74CNU9606	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	intact-crc:9BC281B38AB31673|rigid:HwutslUzP+BVaFBdW7maCSiff2M	false	glutathione s tranferase tag:?-?|sufficient binding region:380-445	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P25102	uniprotkb:Q5JY77	intact:EBI-2625063	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	psi-mi:hrh2_rat(display_long)|uniprotkb:Hrh2(gene name)|psi-mi:Hrh2(display_short)|uniprotkb:Gastric receptor I(gene name synonym)	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615831|imex:IM-20433-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2831|refseq:NP_037097.3|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR000503(Histamine H2 receptor)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0001698"(gastrin-induced gastric acid secretion)|go:"GO:0008542"(visual learning)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048565"(digestive tract development)|go:"GO:0048732"(gland development)|go:"GO:0071420"(cellular response to histamine)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|go:"GO:1901363"(heterocyclic compound binding)|go:"GO:1901998"(toxin transport)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0001697"(histamine-induced gastric acid secretion)|reactome:R-RNO-390650	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	-	-	-	figure legend:Fig 2A|comment:Weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:VdZM9uZiHqyz9m1DsAJ4XASK0gc10116	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	intact-crc:9AC50233C4D3E5FF|rigid:hHJwSDv61ISkPFdASif7QEX597Q	false	glutathione s tranferase tag:?-?|sufficient binding region:284-349	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5JY77	uniprotkb:P21731	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	intact:EBI-2625082|uniprotkb:O75228|uniprotkb:Q6DK52|uniprotkb:Q9UCY1|uniprotkb:Q9UCY2|ensembl:ENSP00000364336	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:ta2r_human(display_long)|uniprotkb:TBXA2R(gene name)|psi-mi:TBXA2R(display_short)|uniprotkb:Prostanoid TP receptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615867|imex:IM-20433-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	refseq:XP_011526516.1|refseq:NP_001051.1|refseq:NP_963998.2|ensembl:ENSG00000006638(gene)|ensembl:ENST00000375190(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0004961"(thromboxane A2 receptor activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001105(Thromboxane receptor)|interpro:IPR008365(Prostanoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P21731|rcsb pdb:1LBN|reactome:R-HSA-391908|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-428930|dip:DIP-41465N	-	-	-	figure legend:Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	rogid:ee/bWzyKVAxt3HIuVZPQ4KNQKNs9606	intact-crc:450A957A100BC8E7|rigid:SvAAxWmP74Yu5LtAIghoaR3SdeI	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:303-343	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5JY77	uniprotkb:P08588	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615888|imex:IM-20433-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	-	-	-	figure legend:Fig 2A and Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	intact-crc:00E2DE2444FC5569|rigid:w/KC+R6LE7BpdLwPhTxnPB2dZ4k	false	35s radiolabel:?-?	mutation decreasing interaction:383-384|glutathione s tranferase tag:?-?|sufficient binding region:373-477	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5JY77	uniprotkb:P30988-1	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	intact:EBI-21497892	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:p30988-1(display_long)|uniprotkb:CALCR(gene name)|psi-mi:CALCR(display_short)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615917|imex:IM-20433-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	intact:EBI-2615663(isoform-parent)	-	-	-	figure legend:Fig 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2021/11/30	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	rogid:MeBI9/06iBZimG8v53qDtWUu3eM9606	intact-crc:F1FA7FAACCB66E01|rigid:iJ6v+4cbPKVsfYx+kxXgPgmHUzc	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:407-c	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11229	uniprotkb:Q96D09	intact:EBI-2624759|ensembl:ENSP00000306490|uniprotkb:Q96RH1	intact:EBI-473189|ensembl:ENSP00000339057|ensembl:ENSP00000437394|ensembl:ENSP00000437872|ensembl:ENSP00000507692|ensembl:ENSP00000508139|uniprotkb:Q8NAB4|uniprotkb:D3DXA0	psi-mi:acm1_human(display_long)|uniprotkb:CHRM1(gene name)|psi-mi:CHRM1(display_short)	psi-mi:gasp2_human(display_long)|uniprotkb:GPRASP2(gene name)|psi-mi:GPRASP2(display_short)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615949|imex:IM-20433-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168539(gene)|ensembl:ENST00000306960(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007399"(nervous system development)|refseq:XP_011543044.1|refseq:NP_000729.2|go:"GO:0016020"(membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0046541"(saliva secretion)|go:"GO:0050890"(cognition)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR002228(Muscarinic acetylcholine receptor M1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5CXV|rcsb pdb:6OIJ|rcsb pdb:6WJC|reactome:R-HSA-390648|reactome:R-HSA-416476|interpro:IPR000995(Muscarinic acetylcholine receptor)	ensembl:ENSG00000158301(gene)|ensembl:ENST00000332262(transcript)|ensembl:ENST00000483720(transcript)|ensembl:ENST00000486814(transcript)|ensembl:ENST00000535209(transcript)|ensembl:ENST00000543253(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:NP_001004051.1|refseq:NP_001171803.1|refseq:NP_001171804.1|refseq:NP_001171805.1|refseq:NP_001186747.1|refseq:NP_612446.1	-	-	-	figure legend:Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:h4KvtChdArk35BJmdzgVwGfbc4A9606	rogid:aUbvpCvGto1y4Rqnri7qaKaygQ89606	intact-crc:C3C0CFAC98AD689F|rigid:Xm8gJ0qV9MX7cgZIAyXKrCnII/o	false	sufficient binding region:414-460|glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P30988-1	uniprotkb:Q96D09	intact:EBI-21497892	intact:EBI-473189|ensembl:ENSP00000339057|ensembl:ENSP00000437394|ensembl:ENSP00000437872|ensembl:ENSP00000507692|ensembl:ENSP00000508139|uniprotkb:Q8NAB4|uniprotkb:D3DXA0	psi-mi:p30988-1(display_long)|uniprotkb:CALCR(gene name)|psi-mi:CALCR(display_short)	psi-mi:gasp2_human(display_long)|uniprotkb:GPRASP2(gene name)|psi-mi:GPRASP2(display_short)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615973|imex:IM-20433-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2615663(isoform-parent)	ensembl:ENSG00000158301(gene)|ensembl:ENST00000332262(transcript)|ensembl:ENST00000483720(transcript)|ensembl:ENST00000486814(transcript)|ensembl:ENST00000535209(transcript)|ensembl:ENST00000543253(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:NP_001004051.1|refseq:NP_001171803.1|refseq:NP_001171804.1|refseq:NP_001171805.1|refseq:NP_001186747.1|refseq:NP_612446.1	-	-	-	figure legend:Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2021/11/30	rogid:MeBI9/06iBZimG8v53qDtWUu3eM9606	rogid:aUbvpCvGto1y4Rqnri7qaKaygQ89606	intact-crc:E5222ED75F6169F8|rigid:/ZkS4vqIbQt4/Pu2nU5YmtnsLSw	false	glutathione s tranferase tag:?-?|sufficient binding region:389-472	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q96D09	uniprotkb:P34969	intact:EBI-473189|ensembl:ENSP00000339057|ensembl:ENSP00000437394|ensembl:ENSP00000437872|ensembl:ENSP00000507692|ensembl:ENSP00000508139|uniprotkb:Q8NAB4|uniprotkb:D3DXA0	intact:EBI-2625020|uniprotkb:B5BUP6|uniprotkb:P78336|uniprotkb:P78372|uniprotkb:P78516|uniprotkb:Q5VX01|uniprotkb:Q5VX02|ensembl:ENSP00000337949|uniprotkb:Q5VX03	psi-mi:gasp2_human(display_long)|uniprotkb:GPRASP2(gene name)|psi-mi:GPRASP2(display_short)	psi-mi:5ht7r_human(display_long)|uniprotkb:HTR7(gene name)|psi-mi:HTR7(display_short)|uniprotkb:5-HT-X(gene name synonym)|uniprotkb:Serotonin receptor 7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615982|imex:IM-20433-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158301(gene)|ensembl:ENST00000332262(transcript)|ensembl:ENST00000483720(transcript)|ensembl:ENST00000486814(transcript)|ensembl:ENST00000535209(transcript)|ensembl:ENST00000543253(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:NP_001004051.1|refseq:NP_001171803.1|refseq:NP_001171804.1|refseq:NP_001171805.1|refseq:NP_001186747.1|refseq:NP_612446.1	refseq:NP_000863.1|refseq:NP_062873.1|refseq:NP_062874.1|ensembl:ENSG00000148680(gene)|ensembl:ENST00000336152(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008015"(blood circulation)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042310"(vasoconstriction)|go:"GO:0045202"(synapse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001069(5-Hydroxytryptamine 7 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-390666|reactome:R-HSA-418555|reactome:R-HSA-9660821|reactome:R-HSA-9706019	-	-	-	figure legend:Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:aUbvpCvGto1y4Rqnri7qaKaygQ89606	rogid:NoHrTf52SNxtQ9a9C5SaPy74CNU9606	intact-crc:D581B7342E491E16|rigid:n8Fr2dalNsAFVKqqRmwRZdS82UY	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:380-445	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q96D09	uniprotkb:P08172	intact:EBI-473189|ensembl:ENSP00000339057|ensembl:ENSP00000437394|ensembl:ENSP00000437872|ensembl:ENSP00000507692|ensembl:ENSP00000508139|uniprotkb:Q8NAB4|uniprotkb:D3DXA0	intact:EBI-2624832|uniprotkb:Q4VBK6|uniprotkb:Q9P1X9|ensembl:ENSP00000319984|ensembl:ENSP00000384401|ensembl:ENSP00000399745|ensembl:ENSP00000415386|ensembl:ENSP00000505686	psi-mi:gasp2_human(display_long)|uniprotkb:GPRASP2(gene name)|psi-mi:GPRASP2(display_short)	psi-mi:acm2_human(display_long)|uniprotkb:CHRM2(gene name)|psi-mi:CHRM2(display_short)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2616024|imex:IM-20433-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158301(gene)|ensembl:ENST00000332262(transcript)|ensembl:ENST00000483720(transcript)|ensembl:ENST00000486814(transcript)|ensembl:ENST00000535209(transcript)|ensembl:ENST00000543253(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:NP_001004051.1|refseq:NP_001171803.1|refseq:NP_001171804.1|refseq:NP_001171805.1|refseq:NP_001186747.1|refseq:NP_612446.1	refseq:XP_011514071.1|refseq:NP_000730.1|refseq:NP_001006627.1|refseq:NP_001006628.1|refseq:NP_001006629.1|refseq:NP_001006630.1|refseq:NP_001006631.1|refseq:NP_001006632.1|refseq:NP_001006633.1|ensembl:ENSG00000181072(gene)|ensembl:ENST00000320658(transcript)|ensembl:ENST00000401861(transcript)|ensembl:ENST00000445907(transcript)|ensembl:ENST00000453373(transcript)|ensembl:ENST00000680005(transcript)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001065(Muscarinic acetylcholine receptor M2)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LUB|rcsb pdb:3UON|rcsb pdb:4MQS|rcsb pdb:4MQT|rcsb pdb:5YC8|rcsb pdb:5ZK3|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|rcsb pdb:5ZKB|rcsb pdb:5ZKC|rcsb pdb:6OIK|rcsb pdb:6U1N|reactome:R-HSA-390648|reactome:R-HSA-418594|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:5ZK8|dip:DIP-56282N	-	-	-	figure legend:Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:aUbvpCvGto1y4Rqnri7qaKaygQ89606	rogid:Rg7s3/iAh4+DTvkasK8G/BWc+yM9606	intact-crc:183FDB558D533646|rigid:UBRkyKKZ51Unf+VTfC39XlGhAXo	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:436-466	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q96D09	uniprotkb:P08588	intact:EBI-473189|ensembl:ENSP00000339057|ensembl:ENSP00000437394|ensembl:ENSP00000437872|ensembl:ENSP00000507692|ensembl:ENSP00000508139|uniprotkb:Q8NAB4|uniprotkb:D3DXA0	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:gasp2_human(display_long)|uniprotkb:GPRASP2(gene name)|psi-mi:GPRASP2(display_short)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2616015|imex:IM-20433-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158301(gene)|ensembl:ENST00000332262(transcript)|ensembl:ENST00000483720(transcript)|ensembl:ENST00000486814(transcript)|ensembl:ENST00000535209(transcript)|ensembl:ENST00000543253(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:NP_001004051.1|refseq:NP_001171803.1|refseq:NP_001171804.1|refseq:NP_001171805.1|refseq:NP_001186747.1|refseq:NP_612446.1	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	-	-	-	figure legend:Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:aUbvpCvGto1y4Rqnri7qaKaygQ89606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	intact-crc:CC204476790B33CF|rigid:nkiJa6qdjxBwMj3U4ShHzJ2c7us	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:373-477	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q96D09	uniprotkb:P25102	intact:EBI-473189|ensembl:ENSP00000339057|ensembl:ENSP00000437394|ensembl:ENSP00000437872|ensembl:ENSP00000507692|ensembl:ENSP00000508139|uniprotkb:Q8NAB4|uniprotkb:D3DXA0	intact:EBI-2625063	psi-mi:gasp2_human(display_long)|uniprotkb:GPRASP2(gene name)|psi-mi:GPRASP2(display_short)	psi-mi:hrh2_rat(display_long)|uniprotkb:Hrh2(gene name)|psi-mi:Hrh2(display_short)|uniprotkb:Gastric receptor I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2616047|imex:IM-20433-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158301(gene)|ensembl:ENST00000332262(transcript)|ensembl:ENST00000483720(transcript)|ensembl:ENST00000486814(transcript)|ensembl:ENST00000535209(transcript)|ensembl:ENST00000543253(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:NP_001004051.1|refseq:NP_001171803.1|refseq:NP_001171804.1|refseq:NP_001171805.1|refseq:NP_001186747.1|refseq:NP_612446.1	rgd:2831|refseq:NP_037097.3|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR000503(Histamine H2 receptor)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007613"(memory)|go:"GO:0001698"(gastrin-induced gastric acid secretion)|go:"GO:0008542"(visual learning)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048565"(digestive tract development)|go:"GO:0048732"(gland development)|go:"GO:0071420"(cellular response to histamine)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|go:"GO:1901363"(heterocyclic compound binding)|go:"GO:1901998"(toxin transport)|go:"GO:0001696"(gastric acid secretion)|go:"GO:0001697"(histamine-induced gastric acid secretion)|reactome:R-RNO-390650	-	-	-	figure legend:Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/15	2014/10/16	rogid:aUbvpCvGto1y4Rqnri7qaKaygQ89606	rogid:VdZM9uZiHqyz9m1DsAJ4XASK0gc10116	intact-crc:ACA7F4947D0AC78F|rigid:509+qkDv7aGIwKIqeM8WHFny8j4	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:284-349	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5JY77	uniprotkb:P32300	intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168	intact:EBI-2615936|ensembl:ENSMUSP00000050077	psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym)	psi-mi:oprd_mouse(display_long)|uniprotkb:MSL-2(gene name synonym)|uniprotkb:K56(gene name synonym)|uniprotkb:Oprd1(gene name)|psi-mi:Oprd1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Frederic et al. (2004)	pubmed:15086532|imex:IM-20433	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2615934|imex:IM-20433-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934	refseq:NP_038650.3|ensembl:ENSMUSG00000050511(gene)|ensembl:ENSMUST00000056336(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031982"(vesicle)|go:"GO:0032590"(dendrite membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038046"(G protein-coupled enkephalin receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0098992"(neuronal dense core vesicle)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000321(Delta opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4EJ4|reactome:R-MMU-375276|reactome:R-MMU-418594|go:"GO:0097444"(spine apparatus)|dip:DIP-46417N	-	-	-	figure legend:Fig 1B|delivery method:P32300; Q5JY77 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2010/03/15	2014/10/16	rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606	rogid:vRlELxpmehNJiVQ1uZf8+HpgQJ410090	intact-crc:78072C46F2A1558C|rigid:UcWybschDZTvjJF0cFTpowlMcMA	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)