#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q00168	uniprotkb:Q24210	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941211|imex:IM-20525-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-larva)|taxid:7227(Drosophila melanogaster larva)	-	2010/11/04	2014/10/16	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227	intact-crc:6F87351C82C08990|rigid:2OWK5HSEiRMe1PZnrdEysi263rw	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q00168	uniprotkb:Q24210	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941268|imex:IM-20525-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361	-	-	-	figure legend:Fig. 1C|delivery method:Q24210, Q00168 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/04	2014/10/16	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227	intact-crc:B9781D9DA57592E5|rigid:2OWK5HSEiRMe1PZnrdEysi263rw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24210	uniprotkb:Q00168	intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym)	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941282|imex:IM-20525-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-head)|taxid:7227(Drosophila melanogaster)	-	2010/11/04	2014/10/16	rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	intact-crc:585FB6CE0F18E449|rigid:2OWK5HSEiRMe1PZnrdEysi263rw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24210	uniprotkb:Q00168	intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym)	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:"MI:0096"(pull down)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941294|imex:IM-20525-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	-	-	-	figure legend:Figs. 1D, 3A, 3C, 3D|stimulant:Nonhydrolyzable ATP analog AMP-PNP|inhibition:ATP|comment:"Ca2+/Calmodulin protects the CaMKII:Cmg complex from dissociation"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/04	2014/10/16	rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	intact-crc:729575CE1DDBABEC|rigid:2OWK5HSEiRMe1PZnrdEysi263rw	false	glutathione s tranferase tag:?-?	mutation decreasing interaction:306-307|mutation decreasing interaction:306-307|mutation decreasing interaction:306-307	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24210	uniprotkb:Q00168	intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym)	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:"MI:0096"(pull down)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941666|imex:IM-20525-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	-	-	-	figure legend:Fig. 4|kinetics:IC50=3.7E-6M|comment:"Complete inhibition of CaMKII binding, with an IC50 of 13 956;M, is seen with a longer peptide (275 310) which contains both the N-terminal and CaM binding sequences of CaMKII"|kinetic_conditions:pH7.2, Temp=4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/04	2014/10/16	rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	intact-crc:659144623456B96B|rigid:2OWK5HSEiRMe1PZnrdEysi263rw	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24210	uniprotkb:Q00168	intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym)	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:"MI:0096"(pull down)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941666|imex:IM-20525-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	-	-	-	figure legend:Fig. 4|kinetics:IC50=3.7E-6M|comment:"Complete inhibition of CaMKII binding, with an IC50 of 13 956;M, is seen with a longer peptide (275 310) which contains both the N-terminal and CaM binding sequences of CaMKII"|kinetic_conditions:pH7.2, Temp=4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/04	2014/10/16	rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	intact-crc:659144623456B96B|rigid:2OWK5HSEiRMe1PZnrdEysi263rw	false	glutathione s tranferase tag:?-?	sufficient binding region:281-302	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:15422"	uniprotkb:Q00168	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:"MI:0030"(cross-linking study)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941308|imex:IM-20525-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	-	-	-	figure legend:Fig. 2B|comment:ATP is 32P radio-labelled|inhibition:ATP|inhibition:ADP|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/04	2014/10/16	-	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	intact-crc:C82BEBE55C1CC31F	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q00168	-	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	-	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	-	psi-mi:"MI:0424"(protein kinase assay)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941711|imex:IM-20525-8	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:Fig. 6A|comment:Activity of CaMKII requires the presence of Ca2+/Calmodulin|resulting-ptm:Phosphorylation of Thr-306|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/04	2014/10/16	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	-	intact-crc:AB8B34E27BD7D675	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	-
intact:EBI-2941680	uniprotkb:Q24210	-	intact:EBI-214423|uniprotkb:Q24272|uniprotkb:Q86P03|uniprotkb:Q86P17|uniprotkb:Q8SX09|uniprotkb:Q9VD77|uniprotkb:Q9VD78|uniprotkb:Q9VD79|uniprotkb:B5X553|ensemblmetazoa:FBpp0083559	psi-mi:autocamtide-3(display_short)|psi-mi:EBI-2941680(display_long)	psi-mi:cskp_drome(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:cmg(gene name synonym)|uniprotkb:CG6703(orf name)|uniprotkb:Caki(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941690|imex:IM-20525-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001097862.1|refseq:NP_524441.2|refseq:NP_732661.1|refseq:NP_732662.2|flybase:FBgn0013759|dip:DIP-19769N|ensemblmetazoa:FBgn0013759(gene)|ensemblmetazoa:FBtr0084161(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007615"(anesthesia-resistant memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0040011"(locomotion)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0061174"(type I terminal bouton)|go:"GO:0072375"(medium-term memory)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900073"(regulation of neuromuscular synaptic transmission)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|reactome:R-DME-212676|reactome:R-DME-6794361	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig. 5A|comment:Activity of CaMKII is independent of the presence of Ca2+/Calmodulin|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/04	2014/10/16	rogid:gXe3CDBwdCRReVK0nz0GjCn3gG4-2	rogid:kRJnLUWt4ROj4wv579+0RfYY48c7227	intact-crc:07AD08543ED98E48|rigid:c4MkDKMVYS+m1m+ly2pkCFzo3k4	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-2941680	uniprotkb:Q00168	-	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	psi-mi:autocamtide-3(display_short)|psi-mi:EBI-2941680(display_long)	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941690|imex:IM-20525-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig. 5A|comment:Activity of CaMKII is independent of the presence of Ca2+/Calmodulin|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/04	2014/10/16	rogid:gXe3CDBwdCRReVK0nz0GjCn3gG4-2	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	intact-crc:07AD08543ED98E48|rigid:c4MkDKMVYS+m1m+ly2pkCFzo3k4	false	-	O-phospho-L-threonine:287-287	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-2941680	uniprotkb:Q00168	-	intact:EBI-124595|uniprotkb:Q59DP1|uniprotkb:Q59DP2|uniprotkb:Q9V495|ensemblmetazoa:FBpp0099496|ensemblmetazoa:FBpp0289607	psi-mi:autocamtide-3(display_short)|psi-mi:EBI-2941680(display_long)	psi-mi:kcc2a_drome(display_long)|uniprotkb:CaMKII(gene name)|psi-mi:CaMKII(display_short)|uniprotkb:CaM(gene name synonym)|uniprotkb:CG18069(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Lu et al. (2003)	pubmed:14687552|imex:IM-20525	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2941702|imex:IM-20525-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	flybase:FBgn0264607|refseq:NP_001162832.1|refseq:NP_001014696.1|refseq:NP_524635.3|refseq:NP_001162831.1|refseq:NP_726633.2|refseq:NP_726634.1|refseq:NP_726635.2|refseq:NP_726636.2|ensemblmetazoa:FBgn0264607(gene)|ensemblmetazoa:FBtr0100146(transcript)|ensemblmetazoa:FBtr0300378(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0007619"(courtship behavior)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060278"(regulation of ovulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:5FG8|rcsb pdb:5H9B|rcsb pdb:5HU3|reactome:R-DME-3371571|reactome:R-DME-4086398|reactome:R-DME-438066|reactome:R-DME-5578775|reactome:R-DME-5673000|reactome:R-DME-936837	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig. 5A|comment:Activity of CaMKII is requires the presence of Ca2+/Calmodulin|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/04	2014/10/16	rogid:gXe3CDBwdCRReVK0nz0GjCn3gG4-2	rogid:jUkYZ4jMtpk9BQOvqv7fXANyxNo7227	intact-crc:3DBD64506ACE138C|rigid:VY9eSQIKqRRDCyuBzXOMPHiCL1o	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)