#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99665	uniprotkb:O14543	intact:EBI-7045630|ensembl:ENSP00000262345|ensembl:ENSP00000497959|ensembl:ENSP00000501329|uniprotkb:B1AN98|uniprotkb:Q2M3V3|intact:MINT-6780861|uniprotkb:B7ZKL9|uniprotkb:F5H7L6	intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341	psi-mi:i12r2_human(display_long)|uniprotkb:IL12RB2(gene name)|psi-mi:IL12RB2(display_short)	psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yamamoto et al. (2003)	pubmed:14559241|mint:MINT-6731574	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7045626|mint:MINT-8033477	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006710680.1|refseq:XP_011539685.1|ensembl:ENSG00000081985(gene)|ensembl:ENST00000262345(transcript)|ensembl:ENST00000648487(transcript)|ensembl:ENST00000674203(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|reactome:R-HSA-8984722|reactome:R-HSA-9020591|refseq:NP_001306162.1|refseq:XP_016856692.1|refseq:NP_001550.1|refseq:NP_001245144.1|refseq:NP_001245143.1|refseq:NP_001245145.1|refseq:XP_005270882.1|refseq:XP_005270884.1|refseq:XP_005270885.1|dip:DIP-6011N|mint:MINT-8033481(identity)|uniprotkb:Q99665(original identifier)	go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|mint:MINT-8033478(identity)|uniprotkb:O14543(original identifier)	-	function:Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production|comment:mint	-	comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2014/10/16	rogid:sEIp9PldsBfySqU9O+sPvz1V5eM9606	rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606	intact-crc:6F43C7DA67C0A35A|rigid:26GrXIg0/bmRc+TCRzn9aB1pNr4	false	binding-associated region:793-806(MINT-8033484)|phosphorylated residue:800-800(MINT-8033486)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)