#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P23727	uniprotkb:P09581	intact:EBI-520244|ensembl:ENSBTAP00000014594	intact:EBI-6305373|ensembl:ENSMUSP00000025523|ensembl:ENSMUSP00000110923|uniprotkb:Q3U3P1|uniprotkb:Q9DBH9	psi-mi:p85a_bovin(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)	psi-mi:csf1r_mouse(display_long)|uniprotkb:Csf1r(gene name)|psi-mi:Csf1r(display_short)|uniprotkb:Csfmr(gene name synonym)|uniprotkb:Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym)	psi-mi:"MI:0096"(pull down)	Reedijk et al. (1992)	pubmed:1314163|mint:MINT-6730287	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7007373|mint:MINT-8037958	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2PNI|rcsb pdb:5DXH|rcsb pdb:5DXU|rcsb pdb:5T8F|rcsb pdb:6D81|rcsb pdb:6D82|rcsb pdb:6D85|rcsb pdb:6D86|rcsb pdb:6D87|rcsb pdb:6G6W|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|rcsb pdb:1BFI|rcsb pdb:1BFJ|rcsb pdb:1OO3|rcsb pdb:1OO4|rcsb pdb:1PNJ|rcsb pdb:1QAD|rcsb pdb:2PNA|rcsb pdb:2PNB|ensembl:ENSBTAG00000010989(gene)|ensembl:ENSBTAT00000014594(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|rcsb pdb:6MRP|rcsb pdb:6OCO|rcsb pdb:6OCU|rcsb pdb:6R4R|rcsb pdb:7JIS|refseq:NP_777000.1|refseq:XP_005221493.1|dip:DIP-34247N|mint:MINT-8037959(identity)|uniprotkb:P23727(original identifier)	reactome:R-MMU-449836|rcsb pdb:4EXP|ensembl:ENSMUSG00000024621(gene)|ensembl:ENSMUST00000025523(transcript)|ensembl:ENSMUST00000115268(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032944"(regulation of mononuclear cell proliferation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|rcsb pdb:3EJJ|dip:DIP-46415N|refseq:XP_006525647.1|refseq:XP_006525648.1|refseq:XP_006525649.1|refseq:NP_001032948.2|refseq:XP_017173299.1|mint:MINT-8037962(identity)|uniprotkb:P09581(original identifier)	-	-	-	comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/29	2014/10/16	rogid:MdV+g/10OfmEeg9kDv5ClV1Z7709913	rogid:jWzzruMZt6wnD2QFpQ4/aov3vlU10090	intact-crc:96988731C2054050|rigid:dIRzs45AavYInxKQhs2rmMXXQ5I	false	-	phosphorylated residue:721-721(MINT-8037967)|binding-associated region:714-727(MINT-8037965)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)