#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8WVM0 uniprotkb:Q00059 intact:EBI-2615570|uniprotkb:Q9Y384|uniprotkb:Q05DR0|ensembl:ENSP00000356134 intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588 psi-mi:tfb1m_human(display_long)|uniprotkb:"S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1"(gene name synonym)|uniprotkb:Mitochondrial 12S rRNA dimethylase 1(gene name synonym)|uniprotkb:Mitochondrial transcription factor B1(gene name synonym)|uniprotkb:CGI-75(orf name)|uniprotkb:TFB1M(gene name)|psi-mi:TFB1M(display_short) psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym) psi-mi:"MI:0858"(immunodepleted coimmunoprecipitation) Vicki et al. (2003) pubmed:12897151|imex:IM-20434 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2615568|imex:IM-20434-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057104.2|ensembl:ENSG00000029639(gene)|ensembl:ENST00000367166(transcript)|go:"GO:0000154"(rRNA modification)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0031167"(rRNA methylation)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR011530(rRNA adenine dimethylase)|interpro:IPR020596|interpro:IPR020598|interpro:IPR023165|interpro:IPR029063|rcsb pdb:6AAX|rcsb pdb:6AJK|reactome:R-HSA-2151201|reactome:R-HSA-6793080 refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding) - - - figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/03/15 2014/10/16 rogid:aw07ohZ/7xuqVv7NvbMOqCTMayM9606 rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606 intact-crc:A9078088634C8D34|rigid:BWYZxF2b0l67nYtzJOaMqlpVH14 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O00411 uniprotkb:Q8WVM0 intact:EBI-355145|uniprotkb:O60370|ensembl:ENSP00000465759 intact:EBI-2615570|uniprotkb:Q9Y384|uniprotkb:Q05DR0|ensembl:ENSP00000356134 psi-mi:rpom_human(display_long)|uniprotkb:POLRMT(gene name)|psi-mi:POLRMT(display_short) psi-mi:tfb1m_human(display_long)|uniprotkb:"S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1"(gene name synonym)|uniprotkb:Mitochondrial 12S rRNA dimethylase 1(gene name synonym)|uniprotkb:Mitochondrial transcription factor B1(gene name synonym)|uniprotkb:CGI-75(orf name)|uniprotkb:TFB1M(gene name)|psi-mi:TFB1M(display_short) psi-mi:"MI:0858"(immunodepleted coimmunoprecipitation) Vicki et al. (2003) pubmed:12897151|imex:IM-20434 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2615586|imex:IM-20434-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005026.3|ensembl:ENSG00000099821(gene)|ensembl:ENST00000588649(transcript)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034245"(mitochondrial DNA-directed RNA polymerase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR002092(DNA-directed RNA polymerase, bacteriophage type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR029262|interpro:IPR037159|interpro:IPR043502|rcsb pdb:3SPA|rcsb pdb:4BOC|rcsb pdb:5OLA|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:7A8P|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0005759"(mitochondrial matrix)|dip:DIP-56412N refseq:NP_057104.2|ensembl:ENSG00000029639(gene)|ensembl:ENST00000367166(transcript)|go:"GO:0000154"(rRNA modification)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0031167"(rRNA methylation)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR011530(rRNA adenine dimethylase)|interpro:IPR020596|interpro:IPR020598|interpro:IPR023165|interpro:IPR029063|rcsb pdb:6AAX|rcsb pdb:6AJK|reactome:R-HSA-2151201|reactome:R-HSA-6793080 - - - figure legend:Fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/03/15 2014/10/16 rogid:88pltXGP9J+KpVZITuRCz2XRhHg9606 rogid:aw07ohZ/7xuqVv7NvbMOqCTMayM9606 intact-crc:BF9E6C8025941EA2|rigid:oKevjiY+leyzW9xQ/4xJsD2MQec false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WVM0 uniprotkb:Q00059 intact:EBI-2615570|uniprotkb:Q9Y384|uniprotkb:Q05DR0|ensembl:ENSP00000356134 intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588 psi-mi:tfb1m_human(display_long)|uniprotkb:"S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1"(gene name synonym)|uniprotkb:Mitochondrial 12S rRNA dimethylase 1(gene name synonym)|uniprotkb:Mitochondrial transcription factor B1(gene name synonym)|uniprotkb:CGI-75(orf name)|uniprotkb:TFB1M(gene name)|psi-mi:TFB1M(display_short) psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym) psi-mi:"MI:0096"(pull down) Vicki et al. (2003) pubmed:12897151|imex:IM-20434 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2615596|imex:IM-20434-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057104.2|ensembl:ENSG00000029639(gene)|ensembl:ENST00000367166(transcript)|go:"GO:0000154"(rRNA modification)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0031167"(rRNA methylation)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR011530(rRNA adenine dimethylase)|interpro:IPR020596|interpro:IPR020598|interpro:IPR023165|interpro:IPR029063|rcsb pdb:6AAX|rcsb pdb:6AJK|reactome:R-HSA-2151201|reactome:R-HSA-6793080 refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding) - - - figure legend:Fig 2A and 5C|caution:The publication describes a 25 amino acid deletion at the C-terminal of TFAM but this could not be accurately mapped to the sequence given in UniProtKB.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/03/15 2014/10/16 rogid:aw07ohZ/7xuqVv7NvbMOqCTMayM9606 rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606 intact-crc:C6BD1383A55B0AC8|rigid:BWYZxF2b0l67nYtzJOaMqlpVH14 false glutathione s tranferase tag:n-n necessary binding region:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H5Q4 uniprotkb:Q00059 intact:EBI-1043912|ensembl:ENSP00000355471|uniprotkb:Q9H626 intact:EBI-1049924|uniprotkb:Q5U0C6|uniprotkb:B5BU05|uniprotkb:A9QXC6|uniprotkb:A8MRB2|ensembl:ENSP00000420588 psi-mi:tfb2m_human(display_long)|uniprotkb:TFB2M(gene name)|psi-mi:TFB2M(display_short)|uniprotkb:NS5ATP5(gene name synonym)|uniprotkb:"S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2"(gene name synonym)|uniprotkb:Mitochondrial 12S rRNA dimethylase 2(gene name synonym)|uniprotkb:Mitochondrial transcription factor B2(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 5(gene name synonym) psi-mi:tfam_human(display_long)|uniprotkb:TCF6(gene name synonym)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6L2(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym) psi-mi:"MI:0096"(pull down) Vicki et al. (2003) pubmed:12897151|imex:IM-20434 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2615604|imex:IM-20434-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071761.1|ensembl:ENST00000366514(transcript)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0031167"(rRNA methylation)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR016861(Mitochondrial dimethyladenosine transferase 2, mitochondrial precursor)|interpro:IPR020598|interpro:IPR029063|mint:Q9H5Q4|rcsb pdb:6ERO|rcsb pdb:6ERP|rcsb pdb:6ERQ|reactome:R-HSA-163282|reactome:R-HSA-2151201|ensembl:ENSG00000162851(gene)|dip:DIP-50540N refseq:NP_003192.1|refseq:NP_001257711.1|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q00059|rcsb pdb:3FGH|rcsb pdb:3TMM|rcsb pdb:3TQ6|rcsb pdb:4NNU|rcsb pdb:4NOD|rcsb pdb:6ERP|rcsb pdb:6ERQ|rcsb pdb:6HB4|rcsb pdb:6HC3|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|reactome:R-HSA-163282|reactome:R-HSA-2151201|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0031072"(heat shock protein binding) - - - figure legend:Fig 2B|caution:The publication describes a 25 amino acid deletion at the C-terminal of TFAM but this could not be accurately mapped to the sequence given in UniProtKB.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/03/15 2014/10/16 rogid:qg7FnDzaxjvzpH+KxQFk52NyvUI9606 rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606 intact-crc:55BE4359410261F1|rigid:UKpMEXVjzoOKmvQKPBOiaFMA2Uc false glutathione s tranferase tag:n-n necessary binding region:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) chebi:"CHEBI:15414" uniprotkb:Q8WVM0 intact:EBI-980183 intact:EBI-2615570|uniprotkb:Q9Y384|uniprotkb:Q05DR0|ensembl:ENSP00000356134 psi-mi:s-adenosyl-l-methionine(display_short)|psi-mi:"CHEBI:15414"(display_long) psi-mi:tfb1m_human(display_long)|uniprotkb:"S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1"(gene name synonym)|uniprotkb:Mitochondrial 12S rRNA dimethylase 1(gene name synonym)|uniprotkb:Mitochondrial transcription factor B1(gene name synonym)|uniprotkb:CGI-75(orf name)|uniprotkb:TFB1M(gene name)|psi-mi:TFB1M(display_short) psi-mi:"MI:0892"(solid phase assay) Vicki et al. (2003) pubmed:12897151|imex:IM-20434 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2615636|imex:IM-20434-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_057104.2|ensembl:ENSG00000029639(gene)|ensembl:ENST00000367166(transcript)|go:"GO:0000154"(rRNA modification)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0031167"(rRNA methylation)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR011530(rRNA adenine dimethylase)|interpro:IPR020596|interpro:IPR020598|interpro:IPR023165|interpro:IPR029063|rcsb pdb:6AAX|rcsb pdb:6AJK|reactome:R-HSA-2151201|reactome:R-HSA-6793080 - - - figure legend:Fig 4|comment:S-adenosyl Methionine is 3H radio-labelled|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/03/15 2015/08/18 - rogid:aw07ohZ/7xuqVv7NvbMOqCTMayM9606 intact-crc:F919203905C17F3F false - glutathione s tranferase tag:n-n|mutation decreasing interaction:65-65 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)