#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q21443 uniprotkb:Q9XTB5 intact:EBI-314110|uniprotkb:O62127|ensemblmetazoa:DY3.2.1|ensemblmetazoa:DY3.2.2 intact:EBI-2535391|ensemblmetazoa:W01G7.5.1 psi-mi:lmn1_caeel(display_long)|uniprotkb:lmn-1(gene name)|psi-mi:lmn-1(display_short)|uniprotkb:lam-1(gene name synonym)|uniprotkb:DY3.2(orf name)|uniprotkb:CeLam-1(gene name synonym)|uniprotkb:Ce-lamin(gene name synonym) psi-mi:lem2_caeel(display_long)|uniprotkb:lem-2(gene name)|psi-mi:lem-2(display_short)|uniprotkb:Ce-MAN1(gene name synonym)|uniprotkb:MAN1 homolog(gene name synonym)|uniprotkb:W01G7.5(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Liu et al. (2003) pubmed:12684533|imex:IM-20425 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2535415|imex:IM-20425-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-9013405|reactome:R-CEL-9035034|refseq:NP_492371.1|wormbase:DY3.2|ensemblmetazoa:DY3.2.1(transcript)|ensemblmetazoa:DY3.2.2(transcript)|ensemblmetazoa:WBGene00003052(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0006997"(nucleus organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0051664"(nuclear pore localization)|go:"GO:0051983"(regulation of chromosome segregation)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR036415|interpro:IPR039008|reactome:R-CEL-4419969|dip:DIP-29640N ensemblmetazoa:W01G7.5.1(transcript)|ensemblmetazoa:WBGene00002275(gene)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005694"(chromosome)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010165"(response to X-ray)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:1902531"(regulation of intracellular signal transduction)|refseq:NP_496944.1|wormbase:W01G7.5|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR034997|interpro:IPR041885|reactome:R-CEL-9668328|reactome:R-CEL-9013405 go:"GO:0005634"(nucleus) - - figure legend:Fig 1A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-larva)|taxid:6239(Immature form of the adult worm) - 2010/01/19 2014/10/16 rogid:LV8WvN7Tglcs/Qqc5u6RZNba9d46239 rogid:igqTZCB+RC90eLGEItz1bI7OX+U6239 intact-crc:E957821C13B96ED5|rigid:la7f3o+vSaCYC4sCYRtLrBICzbY false - - - - psi-mi:"MI:0709"(polyclonal antibody immunostaining) psi-mi:"MI:0709"(polyclonal antibody immunostaining) uniprotkb:Q9XTB5 uniprotkb:Q21443 intact:EBI-2535391|ensemblmetazoa:W01G7.5.1 intact:EBI-314110|uniprotkb:O62127|ensemblmetazoa:DY3.2.1|ensemblmetazoa:DY3.2.2 psi-mi:lem2_caeel(display_long)|uniprotkb:lem-2(gene name)|psi-mi:lem-2(display_short)|uniprotkb:Ce-MAN1(gene name synonym)|uniprotkb:MAN1 homolog(gene name synonym)|uniprotkb:W01G7.5(orf name) psi-mi:lmn1_caeel(display_long)|uniprotkb:lmn-1(gene name)|psi-mi:lmn-1(display_short)|uniprotkb:lam-1(gene name synonym)|uniprotkb:DY3.2(orf name)|uniprotkb:CeLam-1(gene name synonym)|uniprotkb:Ce-lamin(gene name synonym) psi-mi:"MI:0040"(electron microscopy) Liu et al. (2003) pubmed:12684533|imex:IM-20425 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2535453|imex:IM-20425-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:W01G7.5.1(transcript)|ensemblmetazoa:WBGene00002275(gene)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005694"(chromosome)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010165"(response to X-ray)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:1902531"(regulation of intracellular signal transduction)|refseq:NP_496944.1|wormbase:W01G7.5|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR034997|interpro:IPR041885|reactome:R-CEL-9668328|reactome:R-CEL-9013405 reactome:R-CEL-9013405|reactome:R-CEL-9035034|refseq:NP_492371.1|wormbase:DY3.2|ensemblmetazoa:DY3.2.1(transcript)|ensemblmetazoa:DY3.2.2(transcript)|ensemblmetazoa:WBGene00003052(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0006997"(nucleus organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0051664"(nuclear pore localization)|go:"GO:0051983"(regulation of chromosome segregation)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR036415|interpro:IPR039008|reactome:R-CEL-4419969|dip:DIP-29640N go:"GO:0000790" - - figure legend:Fig 1B.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-larva)|taxid:6239(Immature form of the adult worm) - 2010/01/19 2014/10/16 rogid:igqTZCB+RC90eLGEItz1bI7OX+U6239 rogid:LV8WvN7Tglcs/Qqc5u6RZNba9d46239 intact-crc:1A56EA06BA7A6825|rigid:la7f3o+vSaCYC4sCYRtLrBICzbY false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q21443 uniprotkb:Q9XTB5 intact:EBI-314110|uniprotkb:O62127|ensemblmetazoa:DY3.2.1|ensemblmetazoa:DY3.2.2 intact:EBI-2535391|ensemblmetazoa:W01G7.5.1 psi-mi:lmn1_caeel(display_long)|uniprotkb:lmn-1(gene name)|psi-mi:lmn-1(display_short)|uniprotkb:lam-1(gene name synonym)|uniprotkb:DY3.2(orf name)|uniprotkb:CeLam-1(gene name synonym)|uniprotkb:Ce-lamin(gene name synonym) psi-mi:lem2_caeel(display_long)|uniprotkb:lem-2(gene name)|psi-mi:lem-2(display_short)|uniprotkb:Ce-MAN1(gene name synonym)|uniprotkb:MAN1 homolog(gene name synonym)|uniprotkb:W01G7.5(orf name) psi-mi:"MI:0047"(far western blotting) Liu et al. (2003) pubmed:12684533|imex:IM-20425 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2535557|imex:IM-20425-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-9013405|reactome:R-CEL-9035034|refseq:NP_492371.1|wormbase:DY3.2|ensemblmetazoa:DY3.2.1(transcript)|ensemblmetazoa:DY3.2.2(transcript)|ensemblmetazoa:WBGene00003052(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0006997"(nucleus organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0051664"(nuclear pore localization)|go:"GO:0051983"(regulation of chromosome segregation)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR036415|interpro:IPR039008|reactome:R-CEL-4419969|dip:DIP-29640N ensemblmetazoa:W01G7.5.1(transcript)|ensemblmetazoa:WBGene00002275(gene)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005694"(chromosome)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010165"(response to X-ray)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:1902531"(regulation of intracellular signal transduction)|refseq:NP_496944.1|wormbase:W01G7.5|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR034997|interpro:IPR041885|reactome:R-CEL-9668328|reactome:R-CEL-9013405 - - - figure legend:Fig 1D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/19 2014/10/16 rogid:LV8WvN7Tglcs/Qqc5u6RZNba9d46239 rogid:igqTZCB+RC90eLGEItz1bI7OX+U6239 intact-crc:FA536CC703132D59|rigid:la7f3o+vSaCYC4sCYRtLrBICzbY false 35s radiolabel:?-? sufficient binding region:1-333 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q03565 uniprotkb:Q9XTB5 intact:EBI-2535603|uniprotkb:Q9BMU1|ensemblmetazoa:B0464.7.1 intact:EBI-2535391|ensemblmetazoa:W01G7.5.1 psi-mi:baf1_caeel(display_long)|uniprotkb:baf-1(gene name)|psi-mi:baf-1(display_short)|uniprotkb:B0464.7(orf name) psi-mi:lem2_caeel(display_long)|uniprotkb:lem-2(gene name)|psi-mi:lem-2(display_short)|uniprotkb:Ce-MAN1(gene name synonym)|uniprotkb:MAN1 homolog(gene name synonym)|uniprotkb:W01G7.5(orf name) psi-mi:"MI:0047"(far western blotting) Liu et al. (2003) pubmed:12684533|imex:IM-20425 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2535622|imex:IM-20425-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:B0464.7.1(transcript)|ensemblmetazoa:WBGene00000235(gene)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007059"(chromosome segregation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010165"(response to X-ray)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051276"(chromosome organization)|refseq:NP_499085.1|wormbase:B0464.7|interpro:IPR004122(Barrier to autointegration factor, BAF)|interpro:IPR036617 ensemblmetazoa:W01G7.5.1(transcript)|ensemblmetazoa:WBGene00002275(gene)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005694"(chromosome)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010165"(response to X-ray)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:1902531"(regulation of intracellular signal transduction)|refseq:NP_496944.1|wormbase:W01G7.5|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR034997|interpro:IPR041885|reactome:R-CEL-9668328|reactome:R-CEL-9013405 - - - figure legend:Fig 1D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/19 2014/10/16 rogid:HfXvaGjU///qebHwPnaYBMyvfAo6239 rogid:igqTZCB+RC90eLGEItz1bI7OX+U6239 intact-crc:C5649837EC09E7DF|rigid:SPExvMt2m79bNQC1Vm1p/HWHlVU false 35s radiolabel:?-? sufficient binding region:1-333 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9XTB5 uniprotkb:Q03565 intact:EBI-2535391|ensemblmetazoa:W01G7.5.1 intact:EBI-2535603|uniprotkb:Q9BMU1|ensemblmetazoa:B0464.7.1 psi-mi:lem2_caeel(display_long)|uniprotkb:lem-2(gene name)|psi-mi:lem-2(display_short)|uniprotkb:Ce-MAN1(gene name synonym)|uniprotkb:MAN1 homolog(gene name synonym)|uniprotkb:W01G7.5(orf name) psi-mi:baf1_caeel(display_long)|uniprotkb:baf-1(gene name)|psi-mi:baf-1(display_short)|uniprotkb:B0464.7(orf name) psi-mi:"MI:0047"(far western blotting) Liu et al. (2003) pubmed:12684533|imex:IM-20425 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-2535634|imex:IM-20425-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:W01G7.5.1(transcript)|ensemblmetazoa:WBGene00002275(gene)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005694"(chromosome)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010165"(response to X-ray)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:1902531"(regulation of intracellular signal transduction)|refseq:NP_496944.1|wormbase:W01G7.5|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|interpro:IPR011015(LEM-like fold)|interpro:IPR034997|interpro:IPR041885|reactome:R-CEL-9668328|reactome:R-CEL-9013405 ensemblmetazoa:B0464.7.1(transcript)|ensemblmetazoa:WBGene00000235(gene)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0007059"(chromosome segregation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010165"(response to X-ray)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051276"(chromosome organization)|refseq:NP_499085.1|wormbase:B0464.7|interpro:IPR004122(Barrier to autointegration factor, BAF)|interpro:IPR036617 - - - figure legend:Fig 1D.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/01/19 2014/10/16 rogid:igqTZCB+RC90eLGEItz1bI7OX+U6239 rogid:HfXvaGjU///qebHwPnaYBMyvfAo6239 intact-crc:9EDAD840D08DD1B1|rigid:SPExvMt2m79bNQC1Vm1p/HWHlVU false sufficient binding region:400-500 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)